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2023

Evolution of 3D chromatin organization at different scales.
Acemel, R.D. and Lupianez, D.G.
Current Opinion in Genetics & Development 78 : 102019. February 2023

Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma.
Ballhausen, A. and Ben Hamza, A. and Welters, C. and Dietze, K. and Bullinger, L. and Rahn, H.P. and Hartmann, S. and Hansmann, M.L. and Hansmann, L.
Cancer Immunology Immunotherapy 72 (2): 515-521. February 2023

The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing.
Bischoff, N. and Wimberger, S. and Kuehn, R. and Laugesen, A. and Turan, V. and Larsen, B.D. and Sørensen, C.S. and Helin, K. and Bennett, E.P. and Maresca, M. and Brakebusch, C.
Gene and Genome Editing 5 : 100023. June 2023

Combining metabolic pulse labeling and quantitative proteomics to monitor protein synthesis upon viral infection.
Bogdanow, B. and Katsimani, N. and Liu, F. and Selbach, M.
Methods in Molecular Biology 2610 : 149-165. 2023

Small molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Demel, U.M. and Wirth, M. and Yousefian, S. and Zhang, L. and Isaakidis, K. and Dönig, J. and Böger, M. and Singh, N. and Köse, H. and Haas, S. and Müller, S. and Schick, M. and Keller, U.
Haematologica 108 (2): 555-567. February 2023

Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.
Denkinger, C.M. and Janssen, M. and Schäkel, U. and Gall, J. and Leo, A. and Stelmach, P. and Weber, S.F. and Krisam, J. and Baumann, L. and Stermann, J. and Merle, U. and Weigand, M.A. and Nusshag, C. and Bullinger, L. and Schrezenmeier, J.F. and Bornhäuser, M. and Alakel, N. and Witzke, O. and Wolf, T. and Vehreschild, M.J.G.T. and Schmiedel, S. and Addo, M.M. and Herth, F. and Kreuter, M. and Tepasse, P.R. and Hertenstein, B. and Hänel, M. and Morgner, A. and Kiehl, M. and Hopfer, O. and Wattad, M.A. and Schimanski, C.C. and Celik, C. and Pohle, T. and Ruhe, M. and Kern, W.V. and Schmitt, A. and Lorenz, H.M. and Souto-Carneiro, M. and Gaeddert, M. and Halama, N. and Meuer, S. and Kräusslich, H.G. and Müller, B. and Schnitzler, P. and Parthé, S. and Bartenschlager, R. and Gronkowski, M. and Klemmer, J. and Schmitt, M. and Dreger, P. and Kriegsmann, K. and Schlenk, Ri.F. and Müller-Tidow, C.
Nature Cancer 4 (1): 96-107. January 2023

Cardiovascular and metabolic determinants of quality of life in patients with cancer.
Evertz, R. and Gödde, K. and Diehl, C. and Valentova, M. and Garfias-Veitl, T. and Braulke, F. and Wulf, G.G. and Overbeck, T.R. and Bleckmann, A. and König, A.O. and Weinländer, P. and Potthoff, S. and Hadzibegovic, S. and Lena, A. and Keller, U. and Landmesser, U. and Schuster, A. and Anker, M.S. and Hasenfuß, G. and von Haehling, S.
ESC Heart Failure 10 (1): 167-176. February 2023

Thioester and oxyester linkages in the ubiquitin system.
Ferri-Blazquez, A. and Jarosch, E. and Sommer, T.
Methods in Molecular Biology 2602 : 3-18. 2023

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O. and Jia, A. and Kuehn, H.S. and Min, Q. and Pannicke, U. and Schleussner, N. and Thouenon, R. and Yu, Z. and de Los Angeles Astbury, M. and Biggs, C.M. and Galicchio, M. and Garcia-Campos, J.A. and Gismondi, S. and Gonzalez Villarreal, G. and Hildebrand, K.J. and Hönig, M. and Hou, J. and Moshous, D. and Pittaluga, S. and Qian, X. and Rozmus, J. and Schulz, A.S. and Staines-Boone, A.T. and Sun, B. and Sun, J. and Uwe, S. and Venegas-Montoya, E. and Wang, W. and Wang, X. and Ying, W. and Zhai, X. and Zhou, Q. and Akalin, A. and André, I. and Barth, T.F.E. and Baumann, B. and Brüstle, A. and Burgio, G. and Bustamante, J.C. and Casanova, J.L. and Casarotto, M.G. and Cavazzana, M. and Chentout, L. and Cockburn, I.A. and Costanza, M. and Cui, C. and Daumke, O. and Del Bel, K.L. and Eibel, H. and Feng, X. and Franke, V. and Gebhardt, J.C.M. and Götz, A. and Grunwald, S. and Hoareau, B. and Hughes, T.R. and Jacobsen, E.M. and Janz, M. and Jolma, A. and Lagresle-Peyrou, C. and Lai, N. and Li, Y. and Lin, S. and Lu, H.Y. and Lugo-Reyes, S.O. and Meng, X. and Möller, P. and Moreno-Corona, N. and Niemela, J.E. and Novakovsky, G. and Perez-Caraballo, J.J. and Picard, C. and Poggi, L. and Puig-Lombardi, M.E. and Randall, K.L. and Reisser, A. and Schmitt, Y. and Seneviratne, S. and Sharma, M. and Stoddard, J. and Sundararaj, S. and Sutton, H. and Tran, L.Q. and Wang, Y. and Wasserman, W.W. and Wen, Z. and Winkler, W. and Xiong, E. and Yang, A.W.H. and Yu, M. and Zhang, L. and Zhang, H. and Zhao, Q. and Zhen, X. and Enders, A. and Kracker, S. and Martinez-Barricarte, R. and Mathas, S. and Rosenzweig, S.D. and Schwarz, K. and Turvey, S.E. and Wang, J.Y.
Science Immunology 8 (79): eade7953. January 2023

Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP.
Franz, A. and Weber, A.I. and Preußner, M. and Dimos, N. and Stumpf, A. and Ji, Y. and Moreno-Velasquez, L. and Voigt, A. and Schulz, F. and Neumann, A. and Kuropka, B. and Kuehn, R. and Urlaub, H. and Schmitz, D. and Wahl, M.C. and Heyd, F.
Life Science Alliance 6 (3): e202201826. March 2023

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes.
Gainullina, A. and Mogilenko, D.A. and Huang, L.H. and Todorov, H. and Narang, V. and Kim, K.W. and Yng, L.S. and Kent, A. and Jia, B. and Seddu, K. and Krchma, K. and Wu, J. and Crozat, K. and Tomasello, E. and Dress, R. and See, P. and Scott, C. and Gibbings, S. and Bajpai, G. and Desai, J.V. and Maier, B. and This, S. and Wang, P. and Aguilar, S.V. and Poupel, L. and Dussaud, S. and Zhou, T.A. and Angeli, V. and Blander, J.M. and Choi, K. and Dalod, M. and Dzhagalov, I. and Gautier, E.L. and Jakubzick, C. and Lavine, K. and Lionakis, M.S. and Paidassi, H. and Sieweke, M.H. and Ginhoux, F. and Guilliams, M. and Benoist, C. and Merad, M. and Randolph, G.J. and Sergushichev, A. and Artyomov, M.N.
Cell Reports 42 (2): 112046. 28 February 2023

Single-cell multi-omics and lineage tracing to dissect cell fate decision-making.
Haghverdi, L. and Ludwig, L.S.
Stem Cell Reports 18 (1): 13-25. 10 January 2023

Monitoring mitochondrial translation by pulse SILAC.
Imami, K. and Selbach, M. and Ishihama, Y.
Journal of Biological Chemistry : 102865. 2 January 2023 (In Press)

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J. and Gout, E. and Daniau, L. and Lao, J. and Weißert, K. and Ammann, S. and Kühn, R. and Richter, M. and Molenda, C. and Sporbert, A. and Zocholl, D. and Klopfleisch, R. and Lortat-Jacob, H. and Aichele, P. and Kammertoens, T. and Blankenstein, T.
Nature Immunology 2 February 2023 (In Press)

Rapid estimation of 2D relative B(1)(+)-maps from localizers in the human heart at 7T using deep learning.
Krueger, F. and Aigner, C.S. and Hammernik, K. and Dietrich, S. and Lutz, M. and Schulz-Menger, J. and Schaeffter, T. and Schmitter, S.
Magnetic Resonance in Medicine 89 (6): 1002-1015. March 2023

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M. and Temel, D. and Ohlendorf, E. and Zirngibl, F. and Materne, B. and Oevermann, L. and Deubzer, H.E. and Henssen, A.G. and Künkele, A. and Hundsdörfer, P. and von Bernuth, H. and Pruß, A. and Eggert, A. and von Stackelberg, A. and Lang, P. and Schulte, J.H.
Haematologica 108 (1): 267-272. January 2023

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia.
Ling, V.Y. and Straube, J. and Godfrey, W. and Haldar, R. and Janardhanan, Y. and Cooper, L. and Bruedigam, C. and Cooper, E. and Tavakoli Shirazi, P. and Jacquelin, S. and Tey, S.K. and Baell, J. and Huang, F. and Jin, J. and Zhao, Y. and Bullinger, L. and Bywater, M.J. and Lane, S.W.
Leukemia 37 (1): 143-153. January 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
Lopez, C. and Schleussner, N. and Bernhart, S.H. and Kleinheinz, K. and Sungalee, S. and Sczakiel, H.L. and Kretzmer, H. and Toprak, U.H. and Glaser, S. and Wagener, R. and Ammerpohl, O. and Bens, S. and Giefing, M. and Sanchez, J.C.G. and Apic, G. and Hubschmann, D. and Janz, M. and Kreuz, M. and Mottok, A. and Müller, J.M. and Seufert, J. and Hoffmann, S. and Korbel, J.O. and Russell, R.B. and Schule, R. and Trumper, L. and Klapper, W. and Radlwimmer, B. and Lichter, P. and Kuppers, R. and Schlesner, M. and Mathas, S. and Siebert, R.
Haematologica 108 (2): 543-554. 1 February 2023

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
Mansouri, L. and Thorvaldsdottir, B. and Sutton, L.A. and Karakatsoulis, G. and Meggendorfer, M. and Parker, H. and Nadeu, F. and Brieghel, C. and Laidou, S. and Moia, R. and Rossi, D. and Catherwood, M. and Kotaskova, J. and Delgado, J. and Rodríguez-Vicente, A.E. and Benito, R. and Rigolin, G.M. and Bonfiglio, S. and Scarfo, L. and Mattsson, M. and Davis, Z. and Gogia, A. and Rani, L. and Baliakas, P. and Foroughi-Asl, H. and Jylhä, C. and Skaftason, A. and Rapado, I. and Miras, F. and Martinez-Lopez, J. and de la Serna, J. and Rivas, J.M.H. and Thornton, P. and Larráyoz, M.J. and Calasanz, M.J. and Fésüs, V. and Mátrai, Z. and Bödör, C. and Smedby, K.E. and Espinet, B. and Puiggros, A. and Gupta, R. and Bullinger, L. and Bosch, F. and Tazón-Vega, B. and Baran-Marszak, F. and Oscier, D. and Nguyen-Khac, F. and Zenz, T. and Terol, M.J. and Cuneo, A. and Hernández-Sánchez, M. and Pospisilova, S. and Mills, K. and Gaidano, G. and Niemann, C.U. and Campo, E. and Strefford, J.C. and Ghia, P. and Stamatopoulos, K. and Rosenquist, R.
Leukemia 37 (2): 339-347. February 2023

MDC1 maintains active elongation complexes of RNA polymerase II.
Pappas, G. and Munk, S.H.N. and Watanabe, K. and Thomas, Q. and Gál, Z. and Gram, H.H. and Lee, M.H. and Gómez-Cabello, D. and Kanellis, D.C. and Olivares-Chauvet, P. and Larsen, D.H. and Gregersen, L.H. and Maya-Mendoza, A. and Galanos, P. and Bartek, J.
Cell Reports 42 (1): 111979. 31 January 2023

Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
Pennitz, P. and Goekeri, C. and Trimpert, J. and Wyler, E. and Ebenig, A. and Weissfuss, C. and Mühlebach, M.D. and Witzenrath, M. and Nouailles, G.
STAR Protocols 4 (1): 101957. 17 March 2023 (In Press)

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S. and Roske, Y. and Rami, B. and Phan, M.H.Q. and Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120 (4): e2208941120. 24 January 2023

Treatment of infants and children with SARS-CoV-2 monoclonal antibodies: a European case series.
Rau, C. and Auer-Hackenberg, L. and Deubzer, H.E. and Schwabel, E. and Jaros, M. and Diederichs, A. and Lehrnbecher, T. and Holm, M. and von Linstow, M.L. and Martin, L. and Dinges, S.S. and Rothensteiner, M. and Siepermann, M. and Strenger, V. and von Both, U. and Teig, N. and Brinkmann, F. and Leeb, F. and Zeitlinger, M. and Kobbe, R. and Götzinger, F.
Pediatric Infectious Disease Journal 42 (2): 125-129. February 2023

Cantharidin and its analogue norcantharidin inhibit metastasis-inducing genes S100A4 and MACC1.
Schöpe, P.C. and Zinnow, V. and Ishfaq, M.A. and Smith, J. and Herrmann, P. and Shoemaker, R.H. and Walther, W. and Stein, U.
International Journal of Molecular Sciences 24 (2): 1179. 7 January 2023

CYCLeR - a novel tool for the full isoform assembly and quantification of circRNAs.
Stefanov, S.R. and Meyer, I.M.
Nucleic Acids Research 51 (2): e10. 25 January 2023

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
Straube, J. and Eifert, T. and Vu, T. and Janardhanan, Y. and Haldar, R. and von Eyss, B. and Cooper, L. and Bruedigam, C. and Ling, V.Y. and Cooper, E. and Patch, A.M. and Bullinger, L. and Schnoeder, T.M. and Bywater, M. and Heidel, F.H. and Lane, S.W.
Leukemia 4 February 2023 (In Press)

CORUM: the comprehensive resource of mammalian protein complexes-2022.
Tsitsiridis, G. and Steinkamp, R. and Giurgiu, M. and Brauner, B. and Fobo, G. and Frishman, G. and Montrone, C. and Ruepp, A.
Nucleic Acids Research 51 (D1): D539-D545. 6 January 2023

Daratumumab as a novel treatment option in refractory ITP.
Vernava, I. and Schmitt, C.A.
Blood Cells Molecules and Diseases 99 : 102724. March 2023

Getting to the root of branched ubiquitin chains: a review of current methods and functions.
Waltho, A. and Sommer, T.
Methods in Molecular Biology 2602 : 19-38. 2023

Patterns, predictors and prognostic relevance of high-grade hematotoxicity after temozolomide or temozolomide-lomustine in the CeTeG/NOA-09 trial.
Weller, J. and Schäfer, N. and Schaub, C. and Tzaridis, T. and Zeyen, T. and Schneider, M. and Potthoff, A.L. and Giordano, F.A. and Steinbach, J.P. and Zeiner, P.S. and Kowalski, T. and Sabel, M. and Hau, P. and Krex, D. and Grauer, O. and Goldbrunner, R. and Schnell, O. and Tabatabai, G. and Ringel, F. and Schmidt-Graf, F. and Brehmer, S. and Tonn, J.C. and Bullinger, L. and Vajkoczy, P. and Glas, M. and Vatter, H. and Herrlinger, U. and Seidel, C.
Journal of Neuro-Oncology 161 (1): 147-153. January 2023

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.
Xiong, E. and Popp, O. and Salomon, C. and Mertins, P. and Kocks, C. and Rajewsky, K. and Chu, V.T.
Frontiers in Immunology 13 : 1083119. 5 January 2023

Response to anti-SARS-CoV-2 mRNA vaccines in multiple myeloma and chronic lymphocytic leukemia patients.
Zaleska, J. and Kwasnik, P. and Paziewska, M. and Purkot, Jo. and Szabelak, A. and Jurek, M. and Masny, N. and Dziatkiewicz, I. and Pronobis-Szczylik, B. and Piebiak, A. and Szymczyk, A. and Jarosz-Chudzik, K. and Bolkun, L. and Kozlowska, K. and Piszcz, J. and Subocz, E. and Halka, J. and Bator, M. and Kalicinska, E. and Wrobel, T. and Usnarska-Zubkiewicz, L. and Rybka, J. and Deren-Wagemann, I. and Szyca-Smieszniak, M. and Dybko, J. and Hus, I. and Pula, B. and Cichocka, E. and Rymko, M. and Zdunczyk, D. and Ziarkiewicz, M. and Basak, G.W. and Bullinger, L. and Giannopoulos, K.
International Journal of Cancer 15 (4): 705-712. 15 February 2023

2022

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4(+) T cells and is defective in Crohn's disease patients.
Ahlers, J. and Mantei, A. and Lozza, L. and Stäber, M. and Heinrich, F. and Bacher, P. and Hohnstein, T. and Menzel, L. and Yüz, S.G. and Alvarez-Simon, D. and Bickenbach, A.R. and Weidinger, C. and Mockel-Tenbrinck, N. and Kühl, A.A. and Siegmund, B. and Maul, J. and Neumann, C. and Scheffold, A.
Mucosal Immunology 15 (3): 480-490. May 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H. and Flórez, A.F. and Kreth, S. and Brückner, L.M. and Yildiz, U. and Gartlgruber, M. and Odoni, D.I. and Poschet, G. and Garbowicz, K. and Shao, C. and Klein, C. and Meier, J. and Zeisberger, P. and Nadler-Holly, M. and Ziehm, M. and Paul, F. and Burhenne, J. and Bell, E. and Shaikhkarami, M. and Würth, R. and Stainczyk, S.A. and Wecht, E.M. and Kreth, J. and Büttner, M. and Ishaque, N. and Schlesner, M. and Nicke, B. and Stresemann, C. and Llamazares-Prada, M. and Reiling, J.H. and Fischer, M. and Amit, I. and Selbach, M. and Herrmann, C. and Wölfl, S. and Henrich, K.O. and Höfer, T. and Trumpp, A. and Westermann, F.
Nature Cancer 3 (4): 471-485. 28 April 2022

Determinants of expression of SARS-CoV-2 entry related genes in upper and lower airways.
Aliee, H. and Massip, F. and Qi, C. and de Biase, M.S. and van Nijnatten, J. and Kersten, E.T.G. and Kermani, N.Z. and Khuder, B. and Vonk, J.M. and Vermeulen, R.C.H. and Neighbors, M. and Tew, G.W. and Grimbaldeston, M.A. and Ten Hacken, N.H.T. and Hu, S. and Guo, Y. and Zhang, X. and Sun, K. and Hiemstra, P.S. and Ponder, B.A. and Mäkelä, M.J. and Malmström, K. and Rintoul, R.C. and Reyfman, P.A. and Theis, F.J. and Brandsma, C.A. and Adcock, I.M. and Timens, W. and Xu, C.J. and van den Berge, M. and Schwarz, R.F. and Koppelman, G.H. and Nawijn, M.C. and Faiz, A.
Allergy 77 (2): 690-694. February 2022

The monocyte, a maestro in the tumor microenvironment (TME) of breast cancer.
Amer, H.T. and Stein, U. and El Tayebi, H.M.
Cancers 14 (21): 5460. 7 November 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. and Acemel, R.D. and Jedamzick, J. and Bolondi, A. and Cova, G. and Brieske, N. and Kühn, R. and Wittler, L. and Real, F.M. and Lupiáñez, D.G.
Nature Genetics July 2022

De novo whole genome assembly of the Roborovski dwarf hamster (Phodopus roborovskii) genome, an animal model for severe/critical COVID-19.
Andreotti, S. and Altmüller, J. and Quedenau, C. and Borodina, T. and Nouailles, G. and Teixeira Alves, L.G. and Landthaler, M. and Bieniara, M. and Trimpert, J. and Wyler, E.
Genome Biology and Evolution 14 (7): evac100. July 2022

Downregulation of odd-skipped related 2, a novel regulator of epithelial-mesenchymal transition, enables efficient somatic cell reprogramming.
Anh, L.P.H. and Nishimura, K. and Kuno, A. and Nguyen, T.L. and Kato, T. and Ohtaka, M. and Nakanishi, M. and Sugihara, E. and Sato, T.A. and Hayashi, Y. and Fukuda, A. and Hisatake, K.
Stem Cells 40 (4): 397-410. 29 April 2022

Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial.
Arends, C.M. and Dimitriou, S. and Stahler, A. and Hablesreiter, R. and Strzelecka, P.M. and Stein, C.M. and Tilgner, M. and Saiki, R. and Ogawa, S. and Bullinger, L. and Modest, D.P. and Stintzing, S. and Heinemann, V. and Damm, F.
Blood 139 (10): 1593-1597. 10 March 2022

Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.
Arends, C.M. and Liman, T.G. and Strzelecka, P.M. and Kufner, A. and Löwe, P. and Huo, S. and Stein, C.M. and Piper, S.K. and Tilgner, M. and Sperber, P.S. and Dimitriou, S. and Heuschmann, P. and Hablesreiter, R. and Harms, C. and Bullinger, L. and Weber, J.E. and Endres, M. and Damm, F.
Blood 28 November 2022 (In Press)

Management of malignant dysgerminoma of the ovary.
Arndt, T. and Taube, E.T. and Deubzer, H.E. and Rothe, K. and Calaminus, G. and Sehouli, J. and Pietzner, K.
European Journal of Gynaecological Oncology 43 (2): 353-362. 15 April 2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Balasubramanian, S. and Andreani, M. and Goncalves Andrade, J. and Saha, T. and Sundaravinayagam, D. and Garzón, J. and Zhang, W. and Popp, O. and Hiraga, S. and Rahjouei, A. and Rosen, D.B. and Mertins, P. and Chait, B.T. and Donaldson, A.D. and Di Virgilio, M.
eLife 11 : e75047. 13 April 2022

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D. and Hörtenhuber, M. and Balwierz, P.J. and Zehnder, T. and Mukarram, A.K. and Nepal, C. and Várnai, C. and Hadzhiev, Y. and Jimenez-Gonzalez, A. and Li, N. and Wragg, J. and D'Orazio, F.M. and Relic, D. and Pachkov, M. and Díaz, N. and Hernández-Rodríguez, B. and Chen, Z. and Stoiber, M. and Dong, M. and Stevens, I. and Ross, S.E. and Eagle, A. and Martin, R. and Obasaju, O. and Rastegar, S. and McGarvey, A.C. and Kopp, W. and Chambers, E. and Wang, D. and Kim, H.R. and Acemel, R.D. and Naranjo, S. and Łapiński, M. and Chong, V. and Mathavan, S. and Peers, B. and Sauka-Spengler, T. and Vingron, M. and Carninci, P. and Ohler, U. and Lacadie, S.A. and Burgess, S.M. and Winata, C. and van Eeden, F. and Vaquerizas, J.M. and Gómez-Skarmeta, J.L. and Onichtchouk, D. and Brown, B.J. and Bogdanovic, O. and van Nimwegen, E. and Westerfield, M. and Wardle, F.C and Daub, C.O. and Lenhard, B. and Müller, F.
Nature Genetics 54 (7): 1037-1050. July 2022

Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells.
Basti, A. and Malhan, D. and Dumbani, M. and Dahlmann, M. and Stein, U. and Relógio, A.
Cancers 14 (14): 3458. 16 July 2022

State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt, M. and Hülsemann, M. and Löwa, A. and Fatykhova, D. and Hoffmann, K. and Kessler, M. and Mieth, M. and Hellwig, K. and Frey, D. and Langenhagen, A. and Voss, A. and Obermayer, B. and Wyler, E. and Dökel, S. and Gruber, A.D. and Tölch, U. and Hippenstiel, S. and Hocke, A.C. and Hönzke, K.
PLoS ONE 17 (12): e0276115. 20 December 2022

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics.
Bayram, S. and Razzaque, Y.S. and Geisberger, S. and Pietzke, M. and Fürst, S. and Vechiatto, C. and Forbes, M. and Mastrobuoni, G. and Kempa, S.
Frontiers in Molecular Biosciences 9 : 859787. 12 August 2022

Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified clostridium perfringens enterotoxin (CPE).
Beier, L.S. and Piontek, J. and Piontek, A. and Protze, J. and Kobelt, D. and Walther, W.
Methods in Molecular Biology 2521 (3): 173-188. 23 June 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M. and Tucker, E. and Dorel, M. and Winkler, A. and McGearey, A. and Rodriguez-Fos, E. and da Costa, B.M. and Barker, K. and Fyle, E. and Calton, E. and Eising, S. and Ober, K. and Hughes, D. and Koutroumanidou, E. and Carter, P. and Stankunaite, R. and Proszek, P. and Jain, N. and Rosswog, C. and Dorado-Garcia, H. and Molenaar, J.J. and Hubank, M. and Barone, G. and Anderson, J. and Lang, P. and Deubzer, H.E. and Künkele, A. and Fischer, M. and Eggert, A. and Kloft, C. and Henssen, A.G. and Boettcher, M. and Hertwig, F. and Blüthgen, N. and Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
Bishop, M.R. and Dickinson, M. and Purtill, D. and Barba, P. and Santoro, A. and Hamad, N. and Kato, K. and Sureda, A. and Greil, R. and Thieblemont, C. and Morschhauser, F. and Janz, M. and Flinn, I. and Rabitsch, W. and Kwong, Y.L. and Kersten, M.J and Minnema, M.C. and Holte, H. and Chan, E.H.L. and Martinez-Lopez, J. and Müller, A.M.S. and Maziarz, R.T. and McGuirk, J.P. and Bachy, E. and Le Gouill, S. and Dreyling, M. and Harigae, H. and Bond, D. and Andreadis, C. and McSweeney, P. and Kharfan-Dabaja, M. and Newsome, S. and Degtyarev, E. and Awasthi, R. and Del Corral, C. and Andreola, G. and Masood, A. and Schuster, S.J. and Jäger, U. and Borchmann, P. and Westin, J.R.
New England Journal of Medicine 386 (7): 629-639. 17 February 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T. and Funck, K. and Wollweber, F. and Lisicki, E. and von der Malsburg, K. and von der Malsburg, A. and Laborenz, J. and Noel, J.K. and Hessenberger, M. and Jungbluth, S. and Bernert, C. and Kunz, S. and Riedel, D. and Lilie, H. and Jakobs, S. and van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy.
Boeckel, J.N. and Möbius-Winkler, M. and Müller, M. and Rebs, S. and Eger, N. and Schoppe, L. and Tappu, R. and Kokot, K.E. and Kneuer, J.M. and Gaul, S. and Bordalo, D.M. and Lai, A. and Haas, J. and Ghanbari, M. and Drewe-Boss, P. and Liss, M. and Katus, H.A. and Ohler, U. and Gotthardt, M. and Laufs, U. and Streckfuss-Bömeke, K. and Meder, B.
Genomics Proteomics & Bioinformatics 20 (1): 129-146. February 2022

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska, R. and Mikecin, A.M. and Kaschutnig, P. and Fawaz, M. and Büchler-Schäff, M. and Le, D. and Ganuza, M. and Vollmer, A. and Paffenholz, S.V. and Asada, N. and Rodriguez-Correa, E. and Frauhammer, F. and Buettner, F. and Ball, M. and Knoch, J. and Stäble, S. and Walter, D. and Petri, A. and Carreño-Gonzalez, M.J. and Wagner, V. and Brors, B. and Haas, S. and Lipka, D.B. and Essers, M.A.G. and Weru, V. and Holland-Letz, T. and Mallm, J.P. and Rippe, K. and Krämer, S. and Schlesner, M. and McKinney Freeman, S. and Florian, M.C. and King, K.Y. and Frenette, P.S. and Rieger, M.A. and Milsom, M.D.
Cell Stem Cell 29 (8): 1273-1284.e8. 4 August 2022

Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
Boogerd, C.J. and Lacraz, G.P.A. and Vértesy, Á. and van Kampen, S.J. and Perini, I. and de Ruiter, H. and Versteeg, D. and Brodehl, A. and van der Kraak, P. and Giacca, M. and de Jonge, N. and Junker, J.P. and van Oudenaarden, A. and Vink, A. and van Rooij, E.
Cardiovascular Research 16 May 2022 (In Press)

Genotype and intensive pretreatment influence outcome of acute myeloid leukemia patients treated with venetoclax in combination with hypomethylating agents or low-dose cytarabine: "real world" data from germany.
Braitsch, K. and Schmalbrock, L.K. and Jung, P. and Bumeder, I. and Kiewe, P. and Hecker, J.S. and Verbeek, M. and Westermann, J. and Bullinger, L. and Keller, U. and Bassermann, F. and Krönke, J. and Götze, K.S. and Rieger, K.
HemaSphere 6 (9): e759. September 2022

Conditioning with fludarabine and treosulfan compared to FLAMSA-RIC in allogeneic stem cell transplantation for myeloid malignancies: a retrospective single-center analysis.
Braitsch, K. and Schwarz, A. and Koch, K. and Hubbuch, M. and Menzel, H. and Keller, U. and Götze, K.S. and Bassermann, F. and Herhaus, P. and Verbeek, M.
Annals of Hematology 101 (6): 1311-1319. June 2022

Relapse of NPM1-mutated AML with extramedullary manifestation 17 years after allogeneic hematopoietic stem cell transplantation.
Braune, J. and Rieger, K. and Blau, O. and Keller, U. and Bullinger, L. and Krönke, J.
Case Reports in Hematology 2022 : 3317936. 28 December 2022

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
Brauneck, F. and Fischer, B. and Witt, M. and Muschhammer, J. and Oelrich, J. and da Costa Avelar, P.H. and Tsoka, S. and Bullinger, L. and Seubert, E. and Smit, D.J. and Bokemeyer, C. and Ackermann, C. and Wellbrock, J. and Haag, F. and Fiedler, W.
Journal for ImmunoTherapy of Cancer 10 (12): e004794. 22 December 2022

Optimization of synthetic molecular reporters for a mesenchymal glioblastoma transcriptional program by integer programming.
Breitenbach, T. and Schmitt, M.J. and Dandekar, T.
Bioinformatics 38 (17): 4162-4171. 1 September 2022

Taking out the trash: How misfolded proteins are removed from the endoplasmic reticulum.
Brodsky, J.L. and Engelman, D.M. and Hendershot, L.M. and Piana-Agostinetti, S. and Sommer, T.
Faculty Reviews 11 : 29. 5 October 2022

Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation.
Brunner, A.D. and Thielert, M. and Vasilopoulou, C. and Ammar, C. and Coscia, F. and Mund, A. and Hoerning, O.B. and Bache, N. and Apalategui, A. and Lubeck, M. and Richter, S. and Fischer, D.S. and Raether, O. and Park, M.A. and Meier, F. and Theis, F.J. and Mann, M.
Molecular Systems Biology 18 (3): e10798. 1 March 2022

Nivolumab and doxorubicin, vinblastine, and dacarbazine in early-stage unfavorable Hodgkin Lymphoma: final analysis of the randomized german Hodgkin study group phase II NIVAHL trial.
Bröckelmann, P.J. and Bühnen, I. and Meissner, J. and Trautmann-Grill, K. and Herhaus, P. and Halbsguth, T.V. and Schaub, V. and Kerkhoff, A. and Mathas, S. and Bormann, M. and Dickhut, A. and Kaul, H. and Fuchs, M. and Kobe, C. and Baues, C. and Borchmann, P. and Engert, A. and von Tresckow, B.
Journal of Clinical Oncology : JCO2202355. 12 December 2022 (In Press)

CEBPA mutations in AML: site matters.
Bullinger, L.
Blood 139 (1): 6-7. 6 January 2022

Generation of redirected engineered human chimeric antigen receptor (CAR) T cells.
Bunse, M. and Höpken, U.E.
In: Gene therapy of cancer : methods and protocols. Methods in Molecular Biology, 2521 (3). Springer / Humana Press, New York, NY, USA, 67-83. ISBN 9781071624401 23 June 2022

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA interdisciplinary expert consensus.
Buske, C. and Dreyling, M. and Alvarez-Larrán, A. and Apperley, J. and Arcaini, L. and Besson, C. and Bullinger, L. and Corradini, P. and Della Porta, M.G. and Dimopoulos, M. and D’Sa, S. and Eich, H.T. and Foà, R. and Ghia, P. and Gomes da Silva, M. and Gribben, J. and Hajek, R. and Harrison, C. and Heuser, M. and Kiesewetter, B. and Kiladjian, J.J. and Kröger, N. and Moreau, P. and Passweg, J.R. and Peyvandi, F. and Rea, D. and Ribera, J.M. and Robak, T. and San-Miguel, J.F. and Santini, V. and Sanz, G. and Sonneveld, P. and von Lilienfeld-Toal, M. and Wendtner, C. and Pentheroudakis, G. and Passamonti, F.
ESMO Open 7 (2): 100403. April 2022

Obesity, colorectal cancer and MACC1 expression: a possible novel molecular association.
Bähr, I. and Jaeschke, L. and Nimptsch, K. and Janke, J. and Herrmann, P. and Kobelt, D. and Kielstein, H. and Pischon, T. and Stein, U.
International Journal of Oncology 60 (2): 17. February 2022

Building a Healthcare Alliance for Resourceful Medicine Offensive Against Neoplasms in hematologY added value framework for hematologic malignancies: a comparative analysis of existing tools.
Cerisoli, F. and Ali, F. and Bereczky, T. and Bolaños, N. and Bullinger, L. and Dhanasiri, S. and Gallagher, J. and Pérez, S.G. and Geissler, J. and Guillevic, Y. and Harrison, K. and Naoum, A. and Portulano, C. and Rodríguez Vicente, A.E. and Schulze-Rath, R. and Gómez, G.Y. and Sanz, G. and Hernández Rivas, J.M.
Value in Health 25 (10): 1760-1767. October 2022

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Christen, F. and Hablesreiter, R. and Hoyer, K. and Hennch, C. and Maluck-Böttcher, A. and Segler, A. and Madadi, A. and Frick, M. and Bullinger, L. and Briest, F. and Damm, F.
Leukemia 36 (4): 1102-1110. April 2022

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F. and Bjordahl, R. and Goodridge, J.P. and Mahmood, S. and Gaidarova, S. and Abujarour, R. and Davis, Z.B. and Merino, A. and Tuininga, K. and Wang, H. and Kumar, A. and Groff, B. and Witty, A. and Bonello, G. and Huffman, J. and Dailey, T. and Lee, T.T. and Malmberg, K.J. and Walcheck, B. and Höpken, U. and Rehm, A. and Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

Simultaneous genetic ablation of PD-1, LAG-3, and TIM-3 in CD8 T cells delays tumor growth and improves survival outcome.
Ciraolo, E. and Althoff, S. and Ruß, J. and Rosnev, S. and Butze, M. and Pühl, M. and Frentsch, M. and Bullinger, L. and Na, I.K.
International Journal of Molecular Sciences 23 (6): 3207. 16 March 2022

Hemostatic management in an infant with neuroblastoma and severe hemophilia B with extended half-life recombinant factor IX fusion protein.
Cuntz, F. and Deubzer, H.E. and Schulte, J.H. and Nimtz-Talaska, A. and Eggert, A. and Holzhauer, S.
Journal of Pediatric Hematology Oncology 44 (1): e246-e249. 1 January 2022

Brentuximab vedotin-containing escalated BEACOPP variants for newly diagnosed advanced-stage classical Hodgkin lymphoma: follow-up analysis of a randomized phase II study from the German Hodgkin Study Group.
Damaschin, C. and Goergen, H. and Kreissl, S. and Plütschow, A. and Breywisch, F. and Mathas, S. and Meissner, J. and Sökler, M. and Topp, M.S. and Vucinic, V. and Zimmermann, A. and von Tresckow, B. and Fuchs, M. and Engert, A. and Borchmann, P. and Eichenauer, D.A.
Leukemia 36 (2): 580-582. February 2022

Global analysis of human-to-mouse contact-dependent intercellular mRNA and lncRNA transfer in cell culture.
Dasgupta, Sandipan and Dyagi, Daniella Y. and Haimovich, Gal and Wyler, E. and Olender, Tsviya and Singer, Robert H. and Landthaler, M. and Gerst, Jeffrey E
bioRxiv : 2021.11.28.470233v2. 7 March 2022

SPFH protein cage - one ring to rule them all.
Daumke, O. and Lewin, G.R.
Cell Research 32 (2): 117-118. February 2022

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M. and Böger, M. and Yousefian, S. and Grunert, C. and Zhang, L. and Hotz, P.W. and Gottschlich, A. and Köse, H. and Isaakidis, K. and Vonficht, D. and Grünschläger, F. and Rohleder, E. and Wagner, K. and Dönig, J. and Igl, V. and Brzezicha, B. and Baumgartner, F. and Habringer, S. and Löber, J. and Chapuy, B. and Weidinger, C. and Kobold, S. and Haas, S. and Busse, A.B. and Müller, S. and Wirth, M. and Schick, M. and Keller, U.
Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo.
Demel, U.M. and Lutz, R. and Sujer, S. and Demerdash, Y. and Sood, S. and Grünschläger, F. and Kuck, A. and Werner, P. and Blaszkiewicz, S. and Uckelmann, H.J. and Haas, S. and Essers, M.
Blood Advances 6 (11): 3513-3528. 10 June 2022

Ibrutinib- and bortezomib-extended R-CHOP induction in elderly higher-risk patients newly diagnosed with diffuse large B-cell lymphoma - first analysis of toxicity and efficacy signals.
Denker, S. and Bittner, A. and Frick, M. and Kase, J. and Hoffmann, J. and Trenker, C. and Keller, U. and Bogner, C. and Hüttmann, A. and Dürig, J. and Janz, M. and Mathas, S. and Marks, R. and Krohn, U. and Na, I.K. and Bullinger, L. and Schmitt, C.A.
Leukemia & Lymphoma 63 (1): 84-92. January 2022

Anti-SARS-CoV-2 antibody containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19 via increased neutralizing antibody activity – a randomized clinical trial.
Denkinger, C.M. and Janssen, M. and Schäkel, U. and Gall, J. and Leo, A. and Stelmach, P. and Weber, S.F. and Krisam, J. and Baumann, L. and Stermann, J. and Merle, U. and Weigand, M.A. and Nusshag, C. and Bullinger, L. and Schrezenmeier, J.F. and Bornhäuser, M. and Alakel, N. and Witzke, O. and Wolf, T. and Vehreschild, M.J.G.T. and Schmiedel, S. and Addo, M.M. and Herth, F. and Kreuter, M. and Tepasse, P.R. and Hertenstein, B. and Hänel, M. and Morgner, A. and Kiehl, M. and Hopfer, O. and Wattad, M.A. and Schimanski, C.C. and Celik, C. and Pohle, T. and Ruhe, M. and Kern, W.V. and Schmitt, A. and Lorenz, H.M. and Souto-Carneiro, M. and Gaeddert, M. and Halama, N. and Meuer, S. and Kräusslich, H.G. and Müller, B. and Schnitzler, P. and Parthé, S. and Bartenschlager, R. and Gronkowski, M. and Klemmer, J. and Schmitt, M. and Dreger, P. and Kriegsmann, K. and Schlenk, R.F. and Müller-Tidow, C.
medRxiv : 2022.10.10.22280850. 13 October 2022

A deep dive into the circulating ctDNA cosmos to vanquish neuroblastoma.
Deubzer, H.E. and Astrahantseff, K. and Lodrini, M.
Cancer Discovery 12 (12): 2727-2729. 2 December 2022

Personalisierte Medizin in der Kinderonkologie: Wo stehen wir heute?
Deubzer, H.E. and Schulte, J.H. and Eggert, A.
TumorDiagnostik & Therapie 43 (01): 29-44. February 2022

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
Dieckmann, S. and Strohmeyer, A. and Willershäuser, M. and Maurer, S.F. and Wurst, W. and Marschall, S. and Hrabě de Angelis, M. and Kühn, R. and Worthmann, A. and Fuh, M.M. and Heeren, J. and Köhler, N. and Pauling, J.K. and Klingenspor, M.
American Journal of Physiology Endocrinology and Metabolism 322 (2): E85-E100. February 2022

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S. and Company, C. and Song, K. and Lowenstein, E.D. and Riedel, L. and Birchmeier, C. and Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J. and Bamopoulos, S.A. and Köse, H. and Orben, F. and Zang, C. and Pons, M. and den Dekker, A.T. and Brouwer, R.W.W. and Baluapuri, A. and Habringer, S. and Reichert, M. and Illendula, A. and Krämer, O.H. and Schick, M. and Wolf, E. and van IJcken, W.F.J. and Esposito, I. and Keller, U. and Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119 (9): e2105691119. 1 March 2022

Retained functional normal and preleukemic HSCs at diagnosis are associated to good prognosis in DNMT3Amut NPM1mut AMLs.
Donato, E. and Correia, N.C. and Andresen, C. and Karpova, D. and Würth, R. and Klein, C. and Sohn, M. and Przybylla, A. and Zeisberger, P. and Rothfelder, K. and Salih, H.R. and Bonig, H. and Stasik, S. and Röllig, C. and Dolnik, A. and Bullinger, L. and Buchholz, F. and Thiede, C.D. and Hübschmann, D. and Trumpp, A.
Blood Advances 1 December 2022 (In Press)

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. and Pusch, F. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Guillan, K. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Meyer-Liesener, S. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Dubois, F. and Horst, D. and Schulte, J.H. and Spuler, S. and You, D. and Dela Cruz, F. and Kung, A.L. and Haase, K. and Di Virgilio, M. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Simultaneous imaging and flow-cytometry-based detection of multiple fluorescent senescence markers in therapy-induced senescent cancer cells.
Dovjak, E. and Mairhofer, M. and Wöß, C. and Qi, J. and Fan, D.N.Y. and Schmitt, C.A. and Yu, Y.
Journal of Visualized Experiments (185): e63973. 12 July 2022

Deep learning for prediction of population health costs.
Drewe-Boss, P. and Enders, D. and Walker, J. and Ohler, U.
BMC Medical Informatics and Decision Making 22 (1): 32. 3 February 2022

Diverse effects of obesity on antitumor immunity and immunotherapy.
Dyck, L. and Lynch, L.
Trends in Molecular Medicine 29 (2): 112-123. February 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T.L.. and Löhning, M.
Nature Communications 13 (1): 3059. 1 June 2022

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications.
Döhner, H. and Weber, D. and Krzykalla, J. and Fiedler, W. and Wulf, G.G. and Salih, H.R. and Lübbert, M. and Kühn, M. and Schroeder, T. and Salwender, H. and Götze, K.S. and Westermann, J. and Fransecky, L. and Mayer, K. and Hertenstein, B. and Ringhoffer, M. and Tischler, H.J. and Machherndl-Spandl, S. and Schrade, A. and Paschka, P. and Gaidzik, V.I. and Theis, F. and Thol, F.R. and Heuser, M. and Schlenk, R.F. and Bullinger, L. and Saadati, M. and Benner, A. and Larson, R.A. and Stone, R.M. and Döhner, K. and Ganser, A.
Blood Advances 6 (18): 5345-5355. 27 September 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. and Obermayer, B. and Weiner, J.M. and Zimmermann, K. and Anania, C. and Wagner, L.K. and Lyras, E.M. and Sapozhnikova, V. and Lara-Astiaso, D. and Prósper, F. and Lang, R. and Lupiáñez, D.G. and Beule, D. and Höpken, U.E. and Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T(H)2-biased immunization.
Ebenig, A. and Muraleedharan, S. and Kazmierski, J. and Todt, D. and Auste, A. and Anzaghe, M. and Gömer, A. and Postmus, D. and Gogesch, P. and Niles, M. and Plesker, R. and Miskey, C. and Gellhorn Serra, M. and Breithaupt, A. and Hörner, C. and Kruip, C. and Ehmann, R. and Ivics, Z. and Waibler, Z. and Pfaender, S. and Wyler, E. and Landthaler, M. and Kupke, A. and Nouailles, G. and Goffinet, C. and Brown, R.J.P and Mühlebach, M.D.
Cell Reports 40 (7): 111214. 16 August 2022

TCR and CAR engineering of primary human T cells.
Edes, I. and Clauss, J. and Stahn, R. and Sada Japp, A. and Lorenz, F.K.M.
Methods in Molecular Biology 2521 (3): 85-93. 23 June 2022

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.
Eichinger, A. and Poetschger, U. and Glogova, E. and Bader, P. and Basu, O. and Beier, R. and Burkhardt, B. and Classen, C.F. and Claviez, A. and Corbacioglu, S. and Deubzer, H.E. and Greil, J. and Gruhn, B. and Güngör, T. and Kafa, K. and Kühl, J.S. and Lang, P. and Lange, B.S. and Meisel, R. and Müller, I. and Sauer, M.G. and Schlegel, P.G. and Schulz, A. and Stachel, D. and Strahm, B. and Wawer, A. and Peters, C. and Albert, M.H.
Leukemia 36 (11): 2567-2576. November 2022

An integrated pharmacological, structural, and genetic analysis of extracellular versus intracellular ROS production in neutrophils.
Ellson, C.D. and Goretti Riça, I. and Kim, J.S. and Huang, Y.M.M. and Lim, D. and Mitra, T. and Hsu, A. and Wei, E.X. and Barrett, C.D. and Otterbein, L.E. and Hauser, C.J. and Wahl, M. and Delbrück, H. and Heinemann, U. and Oschkinat, H. and Chang, C.E.A. and Yaffe, M.B.
Journal of Molecular Biology 434 (9): 167533. 15 May 2022

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H. and Schöberl, F. and Giurgiu, M. and Leal Silva, R.M. and Scholz, V. and Scharf, F. and Wendlandt, M. and Kleinle, S. and Deschauer, M. and Nübling, G. and Heide, W. and Babacan, S.S. and Schneider, C. and Neuhann, T. and Hahn, K. and Schoser, B. and Holinski-Feder, E. and Wolf, D.A. and Abicht, A.
Brain : awac377. 13 October 2022 (In Press)

Evidence for recombinant GRP78, CALR, PDIA3 and GPI as mediators of genetic instability in human CD34+ cells.
Fabarius, A. and Samra, V. and Drews, O. and Mörz, H. and Bierbaum, M. and Darwich, A. and Weiss, C. and Brendel, S. and Kleiner, H. and Seifarth, W. and Greffrath, W. and Hofmann, W.K. and Schmitt, C.A. and Popp, H.D.
Cancers 14 (12): 2883. 11 June 2022

A cFLIP-flop switch for senolysis.
Fan, D.N.Y. and Schmitt, C.A.
Nature Cancer 3 (11): 1279-1281. November 2022

One gene - two proteins: the C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria.
Fasciani, I. and Petragnano, F. and Wang, Z. and Edwards, R. and Telugu, N. and Pietrantoni, I. and Zauber, H. and Rossi, M. and Zabel, U. and Grieben, M. and Terzenidou, M.E. and Di Gregorio, J. and Pellegrini, C. and Santini, S. and Taddei, A.R. and Poehl, B. and Aringhieri, S. and Aloisi, G. and Marampon, F. and Roman, A. and Diecke, S. and Flati, V. and Giorgi, F. and Amicarelli, F. and Tobin, A.B. and Scarselli, M. and Tokatlidis, K. and Lohse, M.J. and Maggio, R. and Annibale, P.
bioRxiv : 2021.04.13.438299. 26 February 2022

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity.
Feldkamp, J.D. and Vetter, V.M. and Arends, C.M. and Lang, T.J.L. and Bullinger, L. and Damm, F. and Demuth, I. and Frick, M.
Haematologica 107 (7): 1703-1708. July 2022

Assessing evolutionary and developmental transcriptome dynamics in homologous cell types.
Feregrino, C. and Tschopp, P.
Developmental Dynamics 251 (9): 1472-1489. September 2022

Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial.
Ferreri, A.J.M. and Cwynarski, K. and Pulczynski, E. and Fox, C.P. and Schorb, E. and Celico, C. and Falautano, M. and Nonis, A. and La Rosée, P. and Binder, M. and Fabbri, A. and Ilariucci, F. and Krampera, M. and Roth, Al. and Hemmaway, C. and Johnson, P.W. and Linton, K.M. and Pukrop, T. and Gørløv, J.S. and Balzarotti, M. and Hess, G. and Keller, U. and Stilgenbauer, S. and Panse, J. and Tucci, A. and Orsucci, L. and Pisani, F. and Zanni, M. and Krause, S.W. and Schmoll, H.J. and Hertenstein, B. and Rummel, M. and Smith, J. and Thurner, L. and Cabras, G. and Pennese, E. and Ponzoni, M. and Deckert, M. and Politi, L.S. and Finke, J. and Ferranti, A. and Cozens, K. and Burger, E. and Ielmini, N. and Cavalli, F. and Zucca, E. and Illerhaus, G.
Leukemia 36 (7): 1870-1878. July 2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S. and Müllerke, S. and Arnold, A. and Heuberger, J. and Berger, H. and Lin, M. and Mollenkopf, H.J. and Wizenty, J. and Horst, D. and Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Differentiation of cerebral neoplasms with vessel size imaging (VSI).
Foda, A. and Kellner, E. and Gunawardana, A. and Gao, X. and Janz, M. and Kufner, A. and Khalil, A.A. and Geran, R. and Mekle, R. and Fiebach, J.B. and Galinovic, I.
Clinical Neuroradiology 32 (1): 239-248. March 2022

Branch point evolution controls species-specific alternative splicing and regulates long term potentiation.
Franz, A. and Weber, A.I. and Preußner, M. and Dimos, N. and Stumpf, A. and Ji, Y. and Moreno-Velasquez, L. and Voigt, A. and Schulz, F. and Neumann, A. and Kuropka, B. and Kühn, R. and Urlaub, H. and Schmitz, D. and Wahl, M.C. and Heyd, F.
bioRxiv : 2022.09.09.507289. 11 September 2022

Dataset debt in biomedical language modeling.
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In: 2022 Challenges and Perspectives in Creating Large Language Models, 27 May 2022, Virtual, Dublin. May 2022

Protein biomarkers in blood reflect the interrelationships between stroke outcome, inflammation, coagulation, adhesion, senescence and cancer.
Fuellen, G. and Walter, U. and Henze, L. and Böhmert, J. and Palmer, D. and Lee, S. and Schmitt, C.A. and Rudolf, H. and Kowald, A.
Cellular and Molecular Neurobiology 11 August 2022 (In Press)

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso, I. and Zujo, L. and Wiest, I. and Kodajova, P. and Timelthaler, G. and Edtmayer, S. and Zrimšek, M. and Kollmann, S. and Giordano, C. and Kothmayer, M. and Neubauer, H.A. and Dey, S. and Schlederer, M. and Schmalzbauer, B.S. and Limberger, T. and Probst, C. and Pusch, O. and Högler, S. and Tangermann, S. and Merkel, O. and Schiefer, A.I. and Kornauth, C. and Prutsch, N. and Zimmerman, M. and Abraham, B. and Anagnostopoulos, J. and Quintanilla-Martinez, L. and Mathas, S. and Wolf, P. and Stoiber, D. and Staber, P.B. and Egger, G. and Klapper, W. and Woessmann, W. and Look, T.A. and Gunning, P. and Turner, S.D. and Moriggl, R. and Lagger, S. and Kenner, L.
Molecular Cancer 21 (1): 172. 31 August 2022

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
Garipler, G. and Lu, C. and Morrissey, Al. and Lopez-Zepeda, L.S. and Pei, Y. and Vidal, S.E. and Zen Petisco Fiore, A.P. and Aydin, B. and Stadtfeld, M. and Ohler, U. and Mahony, S. and Sanjana, N.E. and Mazzoni, E.O.
Cell Reports 38 (11): 110524. 15 March 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L. and Pick, R. and Montorfani, J. and Sun, M. and Brighouse, D. and Liaudet, N. and Kammertoens, T. and Blankenstein, T. and Page, N. and Bernier-Latamani, J. and Tran, N.L. and Petrova, T.V. and Merkler, D. and Scheiermann, C. and Hugues, S.
Science Advances 8 (23): eabl5162. 8 June 2022

Wie Kochsalz Mitochondrien beeinflusst.
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BIOspektrum 28 (4): 387-389. June 2022

Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression?
Geladaris, A. and Torke, S. and Weber, M.S.
CNS drugs 36 (10): 1019-1030. October 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
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Cell 185 (3): 493-512. 3 February 2022

Epstein-Barr virus-driven B cell lymphoma mediated by a unique LMP1-TRAF6 complex.
Giehler, F. and Ostertag, M. and Sommermann, T. and Weidl, D. and Sterz, K. and Kutz, H. and Feller, S. and Geerlof, A. and Biesinger, B. and Popowicz, G. and Kirchmair, J. and Kieser, A.
Research Square : rs.3.rs-1295699/v1. 4 February 2022

An unusual aspartic acid cluster in the reovirus attachment fiber s1 mediates stability at low pH and preserves trimeric organization.
Glorani, G. and Ruwolt, M. and Holton, N. and Loll, B. and Neu, U.
Journal of Virology 96 (8): e0033122. April 2022

Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O. and Zincke, F. and Eckert, A. and Kobelt, D. and Preissner, S. and Liebeskind, J.M. and Gunkel, N. and Putzker, K. and Lewis, J. and Preissner, S. and Kortüm, B. and Walther, W. and Mura, K. and Bourne, P.E. and Stein, U. and Preissner, R.
Clinical and Translational Medicine 12 (2): e726. 20 February 2022

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
Grasedieck, S. and Cabantog, A. and MacPhee, L. and Im, J. and Ruess, C. and Demir, B. and Sperb, N. and Rücker, F.G. and Döhner, K. and Herold, T. and Pollack, J.R. and Bullinger, L. and Rouhi, A. and Kuchenbauer, F.
Haematologica 107 (8): 1758-1772. August 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J. and Kosel, F. and Goveas, N. and Kranz, A. and Alexopoulou, D. and Rajewsky, K. and Sigal, M. and Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

MACC1-dependent antitumor effect of curcumin in colorectal cancer.
Güllü, N. and Smith, J. and Herrmann, P. and Stein, U.
Nutrients 14 (22): 4792. 12 November 2022

A molecularly characterized preclinical platform of subcutaneous renal cell carcinoma (RCC) patient-derived xenograft models to evaluate novel treatment strategies.
Gürgen, D. and Becker, M. and Dahlmann, M. and Flechsig, S. and Schaeffeler, E. and Büttner, F.A. and Schmees, C. and Bohnert, R. and Bedke, J. and Schwab, M. and Wendler, J.J. and Schostak, M. and Jandrig, B. and Walther, W. and Hoffmann, J.
Frontiers in Oncology 12 : 889789. 21 June 2022

miR-142 favors naïve B cell residence in peripheral lymph nodes.
Hagen, M. and Chakraborty, T. and Olson, W.J. and Heitz, M. and Hermann-Kleiter, N. and Kimpel, J. and Jenewein, B. and Pertoll, J. and Labi, V. and Rajewsky, K. and Derudder, E.
Frontiers in Immunology 13 : 847415. 10 November 2022

Refining AML treatment: the role of genetics in response and resistance evaluation to new agents.
Halik, A. and Arends, C.M. and Bullinger, L. and Damm, F. and Frick, M.
Cancers 14 (7): 1689. 26 March 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D. and Ambrozkiewicz, M.C. and Zinnall, U. and Rusanova, A. and Borisova, E. and Drescher, A.N. and Couce-Iglesias, M. and Villamil, G. and Dannenberg, R. and Imami, K. and Münster-Wandowski, A. and Fauler, B. and Mielke, T. and Selbach, M. and Landthaler, M. and Spahn, C.M.T. and Tarabykin, V. and Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

Widely applicable, extended flow cytometric stem cell enumeration panel for quality control of advanced cellular products.
Haussmann, K. and Streitz, M. and Takvorian, A. and Grund, J. and Skenderi, Z. and Tietze-Bürger, C. and Movassaghi, K. and Künkele, A. and Blum, A. and Bullinger, L.
Scientific Reports 12 (1): 17995. 26 October 2022

Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia.
Hegazy, A.N. and Krönke, J. and Angermair, S. and Schwartz, S. and Weidinger, C. and Keller, U. and Treskatsch, S. and Siegmund, B. and Schneider, T.
BMC Infectious Diseases 22 (1): 537. 13 June 2022

Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G.
Cancer Discovery 12 (2): 293-295. 9 February 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P. and Vonficht, D. and Schnell, A. and Uckelmann, H.J. and Bollhagen, A. and Mahmoud, M.A.A. and Landua, S.L. and van der Salm, E. and Trautmann, C. and Raffel, S. and Grünschläger, F. and Lutz, R. and Ghosh, M. and Renders, S. and Correia, N. and Donato, E. and Dixon, K.O. and Hirche, C. and Andresen, C. and Robens, Cl. and Werner, P.S. and Boch, T. and Eisel, D. and Osen, W. and Pilz, F. and Przybylla, A. and Klein, C. and Buchholz, F. and Milsom, M.D. and Essers, M.A.G. and Eichmüller, S.B. and Hofmann, W.K. and Nowak, D. and Hübschmann, D. and Hundemer, M. and Thiede, C. and Bullinger, L. and Müller-Tidow, C. and Armstrong, S.A. and Trumpp, A. and Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29 (5): 760-775.e10. 5 May 2022

A phase II trial to evaluate the combination of pixantrone and obinutuzumab for patients with relapsed aggressive lymphoma: Final results of the prospective, multicentre GOAL trial.
Hess, G. and Hüttmann, A. and Witzens-Harig, M. and Dreyling, M.H. and Keller, U. and Marks, R. and Ernst, T. and Pott, C. and Viardot, A. and Frontzek, F. and Trautmann, M. and Ruckes, C. and Deuster, O. and Rosenwald, A. and Theobald, M. and Lenz, G.
British Journal of Haematology 198 (3): 482-491. 1 April 2022

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Heynen, G.J.J.E. and Baumgartner, F. and Heider, M. and Patra, U. and Holz, M. and Braune, J. and Kaiser, M. and Schäffer, I. and Bamopoulos, S.A. and Ramberger, E. and Murgai, A. and Ng, Y.L.D. and Demel, U.M. and Laue, D. and Liebig, S. and Krüger, J. and Janz, M. and Nogai, A. and Schick, M. and Mertins, P. and Müller, S. and Bassermann, F. and Krönke, J. and Keller, U. and Wirth, M.
Blood Advances 2 August 2022 (In Press)

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E. and Lisek, K. and Vogel, R. and Wulf-Goldenberg, A. and Alcaniz, J. and Montaudon, E. and Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24 (1): 23. 1 April 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. and Kocks, C. and Leiz, J. and Karaiskos, N. and Boltengagen, A. and Cao, S. and Skopnik, C.M. and Klocke, J. and Hardenberg, J.H. and Stockmann, H. and Gotthardt, I. and Obermayer, B. and Haghverdi, L. and Wyler, E. and Landthaler, M. and Bachmann, S. and Hocke, A.C. and Corman, V. and Busch, J. and Schneider, W. and Himmerkus, N. and Bleich, M. and Eckardt, K.U. and Enghard, P. and Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K. and Obermayer, B. and Hönzke, K. and Fatykhova, D. and Demir, Z. and Löwa, A. and Teixeira-Alves, L.G. and Wyler, E. and Lopez-Rodriguez, E. and Mieth, M. and Baumgardt, M. and Hoppe, J. and Firsching, T.C. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Gruber, A.D. and Ochs, M. and Landthaler, M. and Beule, D. and Suttorp, N. and Hippenstiel, S. and Hocke, A.C. and Kessler, M.
Communications Biology 5 (1): 875. 25 August 2022

MACC1-induced collective migration is promoted by proliferation rather than single cell biomechanics.
Hohmann, T. and Hohmann, U. and Dahlmann, M. and Kobelt, D. and Stein, U. and Dehghani, F.
Cancers 14 (12): 2857. 9 June 2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J. and Bartolomaeus, H. and Löber, U. and Behrens, F. and Bartolomaeus, T.U.P. and Anandakumar, H. and Wimmer, M. and Vu, D.L. and Kuhring, M. and Brüning, U. and Maifeld, A. and Geisberger, S. and Kempa, S. and Schumacher, F. and Kleuser, B. and Bufler, P. and Querfeld, U. and Kitschke, S. and Engler, D. and Kuhrt, L. and Drechsel, O. and Eckardt, K.U. and Forslund, S. and Thürmer, A. and McParland, V. and Kirwan, J. and Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten and Belhaj, S. and Tawalbeh, E. and Nagels, D. and Fröhlich, Y. and Finzer, P. and Ciruela, P. and Sabrià, A. and Herrero, M. and Andrés, C. and Antón, A. and Benmoumene, A. and Asskali, D. and Haidar, H. and von Dahlen, J. and Nicolai, J. and Stiller, M. and Blum, J. and Lange, C. and Adelmann, C. and Schroer, B. and Osmers, U. and Grice, C. and Kirfel, P.P. and Jomaa, H. and Strelow, D. and Hülse, L. and Pigulla, M. and Kreuzer, P. and Tyshaieva, A. and Weber, J. and Wienemann, T. and Kohns Vasconcelos, M. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Scholz, C.J. and Jazmati, N. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Ehlkes, L. and Walker, A. and Dilthey, A.T.
Eurosurveillance 27 (43): 2101089. 27 October 2022

Protocol for fast scRNA-seq raw data processing using scKB and non-arbitrary quality control with COPILOT.
Hsu, C.W. and Shahan, R. and Nolan, T.M. and Benfey, P.N. and Ohler, U.
STAR Protocols 3 (4): 101729. 16 December 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B. and Lelek, S. and Spanjaard, B. and El-Sammak, H. and Simões, M.G. and Mintcheva, J. and Aliee, H. and Schäfer, R. and Meyer, A.M. and Theis, F. and Stainier, D.Y.R. and Panáková, D. and Junker, J.P.
Nature Genetics 54 (8): 1227-1237. August 2022

Calorie restriction enhanced glycogen metabolism to compensate for lipid insufficiency.
Hu, L. and Xia, X. and Zong, Y. and Gu, Y. and Wei, L. and Yin, J.
Molecular Nutrition & Food Research 66 (20): 2200182. October 2022

Women in the European Virus Bioinformatics Center.
Hufsky, F. and Abecasis, A. and Agudelo-Romero, P. and Bletsa, M. and Brown, K. and Claus, C. and Deinhardt-Emmer, S. and Deng, L. and Friedel, C.C. and Gismondi, M.I. and Kostaki, E.G. and Kühnert, D. and Kulkarni-Kale, U. and Metzner, K.J. and Meyer, I.M. and Miozzi, L. and Nishimura, L. and Paraskevopoulou, S. and Pérez-Cataluña, A. and Rahlff, J. and Thomson, E. and Tumescheit, C. and van der Hoek, L. and Van Espen, L. and Vandamme, A.M. and Zaheri, M. and Zuckerman, N. and Marz, M.
Viruses 14 (7): 1522. 12 July 2022

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L. and Luebeck, J. and Dehkordi, S.R. and Colón, C.I. and Li, R. and Wong, I.T.L. and Coruh, C. and Dharanipragada, P. and Lomeli, S.H. and Weiser, N.E. and Moriceau, G. and Zhang, X. and Bailey, C. and Houlahan, K.E. and Yang, W. and González, R.C. and Swanton, C. and Curtis, C. and Jamal-Hanjani, M. and Henssen, A.G. and Law, J.A. and Greenleaf, W.J. and Lo, R.S. and Mischel, P.S. and Bafna, V. and Chang, H.Y.
Nature Genetics 54 (11): 1746–1754. November 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K. and Obermayer, B. and Mache, C. and Fathykova, D. and Kessler, M. and Dökel, S. and Wyler, E. and Baumgardt, M. and Löwa, A. and Hoffmann, K. and Graff, P. and Schulze, J. and Mieth, M. and Hellwig, K. and Demir, Z. and Biere, B. and Brunotte, L. and Mecate-Zambrano, A. and Bushe, J. and Dohmen, M. and Hinze, C. and Elezkurtaj, S. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Schmidt-Ott, K.M. and Busch, J. and Klauschen, F. and Horst, D. and Radbruch, H. and Radke, J. and Heppner, F. and Corman, V.M. and Niemeyer, D. and Müller, M.A. and Goffinet, C. and Mothes, R. and Pascual-Reguant, A. and Hauser, A.E. and Beule, D. and Landthaler, M. and Ludwig, S. and Suttorp, N. and Witzenrath, M. and Gruber, A.D. and Drosten, C. and Sander, L.E. and Wolff, T. and Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
Ihlow, J. and Gross, S. and Busack, L. and Flörcken, A. and Jesse, J. and Schwarz, M. and Neuendorff, N.R. and von Brünneck, A.C. and Anagnostopoulos, I. and Türkmen, S. and Blau, I.W. and Burmeister, T. and Horst, D. and Bullinger, L. and Westermann, J.
Haematologica 107 (8): 1773-1785. August 2022

Monitoring mitochondrial translation by pulse SILAC.
Imami, K. and Selbach, M. and Ishihama, Y.
bioRxiv : 2021.01.31.428997. 8 June 2022

H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L. and Papafotiou, G. and Popp, O. and Mertins, P. and Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10 (10): e005535. 27 October 2022

Impact of the first COVID-19 lockdown in Germany on the rate of acute infections during intensive chemotherapy for Hodgkin lymphoma.
Jacob, A.S. and Kaul, H. and Fuchs, M. and Gillessen, S. and Kreissl, S. and Pluetschow, A. and Momotow, J. and Schaub, V. and Huettmann, A. and Haenel, M. and Zimmermann, A. and Dierlamm, J. and Meissner, J. and Mathas, S. and Martin, S. and Engert, A. and Hallek, M. and Borchmann, P. and Lehmann, C.
Infection 50 (4): 925-932. August 2022

Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N. and Jahn, E. and Saadati, M. and Bullinger, L. and Larson, R.A. and Ottone, T. and Amadori, S. and Prior, T.W. and Brandwein, J.M. and Appelbaum, F.R. and Medeiros, B.C. and Tallman, M.S. and Ehninger, G. and Heuser, M. and Ganser, A. and Pallaud, C. and Gathmann, I. and Krzykalla, J. and Benner, A. and Bloomfield, C.D. and Thiede, C. and Stone, R.M. and Döhner, H. and Döhner, K.
Leukemia 36 (9): 2218-2227. September 2022

Semi-automated assembly of high-quality diploid human reference genomes.
Jarvis, E.D. and Formenti, G. and Rhie, A. and Guarracino, A. and Yang, C. and Wood, J. and Tracey, A. and Thibaud-Nissen, F. and Vollger, M.R. and Porubsky, D. and Cheng, H. and Asri, M. and Logsdon, G.A. and Carnevali, P. and Chaisson, M.J.P. and Chin, C.S. and Cody, S. and Collins, J. and Ebert, P. and Escalona, M. and Fedrigo, O. and Fulton, R.S. and Fulton, L.L. and Garg, S. and Gerton, J.L. and Ghurye, J. and Granat, A. and Green, R.E. and Harvey, W. and Hasenfeld, P. and Hastie, A. and Haukness, M. and Jaeger, E.B. and Jain, M. and Kirsche, M. and Kolmogorov, M. and Korbel, J.O. and Koren, S. and Korlach, J. and Lee, J. and Li, D. and Lindsay, T. and Lucas, J. and Luo, F. and Marschall, T. and Mitchell, M.W. and McDaniel, J. and Nie, F. and Olsen, H.E. and Olson, N.D. and Pesout, T. and Potapova, T. and Puiu, D. and Regier, A. and Ruan, J. and Salzberg, S.L. and Sanders, A.D. and Schatz, M.C. and Schmitt, A. and Schneider, V.A. and Selvaraj, S. and Shafin, K. and Shumate, A. and Stitziel, N.O. and Stober, C. and Torrance, J. and Wagner, J. and Wang, J. and Wenger, A. and Xiao, C. and Zimin, A.V. and Zhang, G. and Wang, T. and Li, H. and Garrison, E. and Haussler, D. and Hall, I. and Zook, J.M. and Eichler, E.E. and Phillippy, A.M. and Paten, B. and Howe, K. and Miga, K.H.
Nature 611 (7936): 519-531. 17 November 2022

Efficacy and feasibility of proton beam therapy in relapsed high-risk neuroblastoma-experiences from the prospective KiProReg registry.
Jazmati, D. and Hero, B. and Thole-Kliesch, T.M. and Merta, J. and Deubzer, H.E. and Bäumer, C. and Heinzelmann, F. and Schleithoff, S.S. and Koerber, F. and Eggert, A. and Schwarz, R. and Simon, T. and Timmermann, B.
Current oncology 29 (11): 8222-8234. November 2022

Functional analysis of structural variants in single cells using Strand-seq.
Jeong, H. and Grimes, K. and Rauwolf, K.K. and Bruch, P.M. and Rausch, T. and Hasenfeld, P. and Benito, E. and Roider, T. and Sabarinathan, R. and Porubsky, D. and Herbst, S.A. and Erarslan-Uysal, B. and Jann, J.C. and Marschall, T. and Nowak, D. and Bourquin, J.P. and Kulozik, A.E. and Dietrich, S. and Bornhauser, B. and Sanders, A.D. and Korbel, J.O.
Nature Biotechnology 24 November 2022 (In Press)

Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J. and Großkinsky, U. and Gerlach, K. and Künkele, A. and Höpken, U.E. and Rehm, A.
Molecular Therapy - Methods and Clinical Development 24 : 181-198. 10 March 2022

Transient activated fibroblasts contribute to zebrafish heart regeneration.
Junker, J.P. and Panáková, D.
Nature Genetics 54 (8): 1076-1077. August 2022

Significant reduced loss of bone mineral density after four vs. six cycles of R-CHOP: an analysis of the FLYER-trial.
Kaddu-Mulindwa, D. and Lesan, V. and Berdel, C. and Stilgenbauer, S. and Bewarder, M. and Thurner, L. and Witzens-Harig, M. and Viardot, A. and Soekler, M. and Keller, U. and Truemper, L. and Christofyllakis, K. and Fleser, O. and Bittenbring, J.T. and Poeschel, V. and Held, G. and Jagoda, P.
Leukemia & Lymphoma 63 (2): 326-334. February 2022

Small molecule inhibitors for hepatocellular carcinoma: advances and challenges.
Kamal, M.A. and Mandour, Y.M. and Abd El-Aziz, M.K. and Stein, U. and El Tayebi, H.M.
Molecules 27 (17): 5537. 1 September 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M. and Lin, M. and Maertzdorf, J. and Heuberger, J. and Muellerke, S. and Zuo, X. and Vidal, R. and Shureiqi, I. and Fischer, A.S. and Sauer, S. and Berger, H. and Kidess, E. and Mollenkopf, H.J. and Tacke, F. and Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J. and Du, W. and Pruene, A. and Braun, T. and Thommandru, B. and Turk, R. and Sturgeon, M.L. and Kurgan, G.L. and Amini, L. and Stein, M. and Zittel, T. and Martini, S. and Ostendorf, L. and Wilhelm, A. and Akyüz, L. and Rehm, A. and Hoepken, U.E. and Pruß, A. and Künkele, A. and Jacobi, A.M. and Volk, H.D. and Schmueck-Henneresse, M. and Stripecke, R. and Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25 : 311-330. 9 June 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M. and Schaupp, A.L. and Sun, R. and Coscia, F. and Dendrou, C.A. and Cortes, A. and Kaur, G. and Evans, H.G. and Mollbrink, A. and Navarro, J.F. and Sonner, J.K. and Mayer, C. and DeLuca, G.C. and Lundeberg, J. and Matthews, P.M. and Attfield, K.E. and Friese, M.A. and Mann, M. and Fugger, L.
Nature Neuroscience 25 (7): 944-955. July 2022

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L. and Petkovic, M. and Watkins, T.B.K. and Colliver, E.C. and Laskina, S. and Thapa, N. and Minussi, D.C. and Navin, N. and Swanton, C. and Van Loo, P. and Haase, K. and Tarabichi, M. and Schwarz, R.F.
Genome Biology 23 (1): 241. 14 November 2022

A brief introduction to current cancer gene therapy.
Kobelt, D. and Pahle, J. and Walther, W.
Methods in Molecular Biology 2521 (3): 1-21. 23 June 2022

Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade.
Kofla, G. and Radecke, C. and Frentsch, M. and Walther, W. and Stintzing, S. and Riess, H. and Bullinger, L. and Na, I.K.
OncoImmunology 11 (1): 2068109. 25 April 2022

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W. and Akalin, A. and Ohler, U.
Nature Machine Intelligence 4 (2): 162-168. February 2022

EASIX and severe endothelial complications after CD19-directed CAR-T Cell therapy-a cohort study.
Korell, F. and Penack, O. and Mattie, M. and Schreck, N. and Benner, A. and Krzykalla, J. and Wang, Z. and Schmitt, M. and Bullinger, L. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Frontiers in Immunology 13 : 877477. 8 April 2022

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis.
Kortüm, B. and Radhakrishnan, H. and Zincke, F. and Sachse, C. and Burock, S. and Keilholz, U. and Dahlmann, M. and Walther, W. and Dittmar, G. and Kobelt, D. and Stein, U.
Oncogene 41 (39): 4446-4458. 23 September 2022

Deletion in the Y chromosome of B10.BR-Y(del) mice alters transcription from MSYq genes and has moderate effect on DNA methylation.
Kotarska, K. and Doniec, A. and Korostyński, M. and Piechota, M. and Gołas, A. and Lisowski, P. and Styrna, J.
Reproductive Biology 22 (2): 100614. June 2022

Reduced splenic uptake on (68)Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis.
Kraus, S. and Klassen, P. and Kircher, M. and Dierks, A. and Habringer, S. and Gäble, A. and Kortüm, K.M. and Weinhold, N. and Ademaj-Kospiri, V. and Werner, R.A. and Schirbel, A. and Buck, A.K. and Herhaus, P. and Wester, H.J. and Rosenwald, A. and Weber, W.A. and Einsele, H. and Keller, U. and Rasche, L. and Lapa, C.
Theranostics 12 (13): 5986-5994. 8 August 2022

Synchrones Auftreten eines Adenokarzinoms und eines Non-Hodgkin B-Zell-Lymphoms bei einem Patienten mit einem variablen Immundefektsyndrom (CVID) [When malignancy hits twice - synchronous gastric carcinoma and non-Hodgkin-B-cell lymphoma in a patient with common variable immunodeficiency].
Krick, D. and Hauptmann, K. and Penndorf, V. and Tacke, F. and Krüger, R. and von Bernuth, H. and Sigal, M.
Zeitschrift fur Gastroenterologie 22 November 2022 (In Press)

Small cell lung cancer stem cells display mesenchymal properties and exploit immune checkpoint pathways in activated cytotoxic T lymphocytes.
Kursunel, M.A. and Taskiran, E.Z. and Tavukcuoglu, E. and Yanik, H. and Demirag, F. and Karaosmanoglu, B. and Ozbay, F.G. and Uner, A. and Esendagli, D. and Kizilgoz, D. and Yilmaz, U. and Esendagli, G.
Cancer Immunology Immunotherapy 71 (2): 445-459. February 2022

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.
Kurtova, A.V. and Heinlein, M. and Haas, S. and Velten, L. and Dijkgraaf, G.J.P. and Storm, E.E. and Kljavin, N.M. and Boumahdi, S. and Himmels, P. and Herault, A. and Mancini, A.G. and Koeppen, H. and Dail, M. and Yan, M. and Zhang, J. and Koch, U. and Radtke, F. and Modrusan, Z. and Metcalfe, C. and Piskol, R. and de Sauvage, F.J.
Blood Advances 1 August 2022 (In Press)

Genome engineering in rodents - status quo and perspectives.
Kühn, R.
Laboratory Animals 56 (1): 83-87. 1 February 2022

Rapid single-cell identification of Epstein-Barr virus-specific T-cell receptors for cellular therapy.
Lammoglia Cobo, M.F. and Welters, C. and Rosenberger, L. and Leisegang, M. and Dietze, K. and Pircher, C. and Penter, L. and Gary, R. and Bullinger, L. and Takvorian, A. and Moosmann, A. and Dornmair, K. and Blankenstein, T. and Kammertöns, T. and Gerbitz, A. and Hansmann, L.
Cytotherapy 24 (8): 818-826. August 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T. and Rose, J.C. and Chen, C.Y. and Pichugin, Y. and Xie, L. and Tang, J. and Hung, K.L. and Yost, K.E. and Shi, Q. and Erb, M.L. and Rajkumar, U. and Wu, S. and Taschner-Mandl, S. and Bernkopf, M. and Swanton, C. and Liu, Z. and Huang, W. and Chang, H.Y. and Bafna, V. and Henssen, A.G. and Werner, B. and Mischel, P.S.
Nature Genetics 54 (10): 1527-1533. October 2022

A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments.
Langenhan, J. and Jaeger, C. and Baum, K. and Simon, M. and Lisec, J.
Metabolites 12 (5): 408. 29 April 2022

Sox9 is required for nail bed differentiation and digit tip regeneration.
Lao, M. and Hurtado, A. and de Castro, A.C. and Burgos, M. and Jiménez, R. and Barrionuevo, F.J.
Journal of Investigative Dermatology 142 (10): 2613-2622. October 2022

Editorial: Lineage tracing, hematopoietic stem cell and immune cell dynamics.
Lareau, C.A. and Romagnani, C. and Ludwig, L.S.
Frontiers in Immunology 13 : 1062415. 18 October 2022

Efficient CRISPR/Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators.
Le, T.A. and Chu, V.T. and Lino, A.C. and Schrezenmeier, E. and Kressler, C. and Hamo, D. and Rajewsky, K. and Dörner, T. and Dang, V.D.
Molecular Therapy - Nucleic Acids 30 : 621-632. 13 December 2022

Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M. and Foglierini, M. and Khorkova, S. and Vázquez García, C. and Ratswohl, C. and Davydov, A.N. and Turchaninova, M.A. and Daubenberger, C. and Chudakov, D.M. and Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
Letizia, M. and Wang, Y.H. and Kaufmann, U. and Gerbeth, L. and Sand, A. and Brunkhorst, M. and Weidner, P. and Ziegler, J.F. and Böttcher, C. and Schlickeiser, S. and Fernández, C. and Yamashita, M. and Stauderman, K. and Sun, K. and Kunkel, D. and Prakriya, M. and Sanders, A.D. and Siegmund, B. and Feske, S. and Weidinger, C.
EMBO Molecular Medicine : e15687. 2 August 2022

A weak-labelling and deep learning approach for in-focus object segmentation in 3D widefield microscopy.
Li, R. and Kudryashev, M. and Yakimovich, A.
Research Square : rs.3.rs-2362531/v1. 20 December 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D. and Oshima, M. and Stange, D.E. and Sigal, M.
Gastroenterology 162 (4): 1067-1087. April 2022

Mako: a graph-based pattern growth approach to detect complex structural variants.
Lin, J. and Yang, X. and Kosters, W. and Xu, T. and Jia, Y. and Wang, S. and Zhu, Q. and Ryan, M. and Guo, L. and Zhang, C. and Lee, C. and Devine, S.E. and Eichler, E.E. and Ye, K.
Genomics, Proteomics and Bioinformatics 20 (1): 205-218. February 2022

Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T. and Zhang, Y. and Vadas, O. and Roske, Y. and Gulluni, F. and De Santis, M.C. and Zagar, A.V. and Stephanowitz, H. and Hirsch, E. and Liu, F. and Daumke, O. and Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29 (3): 218-228. March 2022

Circulating cell-free DNA assessment in biofluids from children with neuroblastoma demonstrates feasibility and potential for minimally invasive molecular diagnostics.
Lodrini, M. and Wünschel, J. and Thole-Kliesch, T.M. and Grimaldi, M. and Sprüssel, A. and Linke, R.B. and Hollander, J.F. and Tiburtius, D. and Künkele, A. and Schulte, J.H. and Lankes, E. and Elgeti, T. and Hundsdörfer, P. and Astrahantseff, K. and Simon, T. and Eggert, A. and Deubzer, H.E.
Cancers 14 (9): 2080. 21 April 2022

A congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1.
Ludwig, L.S. and Lareau, C.A. and Bao, E.L. and Liu, N. and Utsugisawa, T. and Tseng, A.M. and Myers, S.A. and Verboon, J.M. and Ulirsch, J.C. and Luo, W. and Muus, C. and Fiorini, C. and Olive, M.E. and Vockley, C.M. and Munschauer, M. and Hunter, A. and Ogura, H. and Yamamoto, T. and Inada, H. and Nakagawa, S. and Ozono, S. and Subramanian, V. and Chiarle, R. and Glader, B. and Carr, S.A. and Aryee, M.J. and Kundaje, A. and Orkin, S. and Regev, A. and McCavit, T. and Kanno, H. and Sankaran, V.G.
Blood 139 (16): 2534-2546. 21 April 2022

Tongue immune compartment analysis reveals spatial macrophage heterogeneity.
Lyras, E.M. and Zimmermann, K. and Wagner, L.K. and Dörr, D. and Klose, C.S.N and Fischer, C. and Jung, S. and Yona, S. and Hovav, A.H. and Stenzel, W. and Dommerich, S. and Conrad, T. and Leutz, A. and Mildner, A.
eLife 11 : 77490. 24 June 2022

In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasets.
Mari, T. and Mösbauer, K. and Wyler, E. and Landthaler, M. and Drosten, C. and Selbach, M.
Journal of Proteome Research 21 (6): 1575-1587. 3 June 2022

Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
Marino, S.F. and Jerke, U. and Rolle, S. and Daumke, O. and Kettritz, R.
Journal of Biological Chemistry 298 (3): 101598. March 2022

The little skate genome and the evolutionary emergence of wing-like fin appendages.
Marletaz, F. and de la Calle-Mustienes, E. and Acemel, R.D. and Nakamura, T. and Paliou, C. and Naranjo, S. and Martinez-Garcia, P.M. and Cases, I. and Sleight, V.A. and Hirschberger, C. and Marcet-Houben, M. and Navon, D. and Andrescavage, A. and Skvortsova, K. and Duckett, P.E. and Gonzalez-Rajal, A. and Bogdanovic, O. and Gibcus, J.H. and Yang, L. and Gallardo-Fuentes, L. and Sospedra, I. and Lopez-Rios, J. and Darbellay, F. and Visel, A. and Dekker, J. and Shubin, N. and Gabaldon, T. and Tena, J.J. and Lupianez, D.G. and Rokhsar, D.S. and Gomez-Skarmeta, J.L.
bioRxiv : 2022.03.21.485123. 22 March 2022

Towards reliable quantification of cell state velocities.
Marot-Lassauzaie, V. and Bouman, B.J. and Donaghy, F.D. and Demerdash, Y. and Essers, M.A.G. and Haghverdi, L.
PLoS Computational Biology 18 (9): e1010031. 28 September 2022

Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN).
Maschmeyer, G. and Bullinger, L. and Garcia-Vidal, C. and Herbrecht, R. and Maertens, J. and Menna, P. and Pagano, L. and Thiebaut-Bertrand, A. and Calandra, T.
Leukemia 36 (5): 1215-1226. May 2022

ATACing single cells with phages.
Maschmeyer, P. and Haas, S.
Molecular Cell 82 (2): 234-236. 20 January 2022

Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A. and Plewka, J. and Chykunova, Y. and Jones, A.N. and Pachota, M. and Rawski, M. and Mourão, A. and Karim, A. and Kresik, L. and Lis, K. and Minia, I. and Hartman, K. and Sonani, R. and Schlauderer, F. and Dubin, G. and Sattler, M. and Suder, P. and Popowicz, G. and Pyrć, K. and Czarna, A.
bioRxiv : 2022.01.25.477673. 1 March 2022

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Mattonet, K. and Kempfer, R. and Hirsekorn, A. and Bilić, I. and Gil, M. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
Cell Genomics 2 (1): 100083. 13 January 2022

Physiological functions of intracellular protein degradation.
McShane, E. and Selbach, M.
Annual Review of Cell and Developmental Biology 38 : 241-262. October 2022

Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets.
Melder, F.T. and Lindemann, P. and Welle, A. and Trouillet, V. and Heißler, S. and Nazaré, M. and Selbach, M.
ChemMedChem 17 (19): e202200346. 6 October 2022

Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A. and Sprink, T. and Noel, J.K. and Vázquez-Sarandeses, E. and van Hoorn, C. and Mohd, S. and Loerke, J. and Spahn, C.M.T. and Daumke, O.
Nature Communications 13 (1): 7641. 10 December 2022

Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry.
Menzel, L. and Zschummel, M. and Rehm, A.
STAR Protocols 3 (2): 101267. 17 June 2022

A high-resolution map of small-scale inversions in the gibbon genome.
Mercuri, L. and Palmisano, D. and L'Abbate, A. and D'Addabbo, P. and Montinaro, F. and Catacchio, C.R. and Hasenfeld, P. and Ventura, M. and Korbel, J.O. and Sanders, A.D. and Maggiolini, F.A.M. and Antonacci, F.
Genome Research 32 (10): 1941-1951. October 2022

Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington's disease models.
Metzger, J.J. and Pereda, C. and Adhikari, A. and Haremaki, T. and Galgoczi, S. and Siggia, E.D. and Brivanlou, A.H. and Etoc, F.
Cell Reports Methods 2 (9): 100297. 19 September 2022

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L. and Braun, J. and Fauchere, F. and Vanshylla, K. and Loyal, L. and Henze, L. and Kruse, B. and Dingeldey, M. and Jürchott, K. and Mangold, M. and Maraj, A. and Braginets, A. and Böttcher, C. and Nitsche, A. and de la Rosa, K. and Ratswohl, C. and Sawitzki, B. and Holenya, P. and Reimer, U. and Sander, L.E. and Klein, F. and Paul, F. and Bellmann-Strobl, J. and Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C. and Lisowski, P. and Lickfett, S. and Mlody, B. and Bünning, M. and Genehr, C. and Ulrich, C. and Wanker, E.E. and Diecke, S. and Priller, J. and Prigione, A.
Stem Cell Research 65 : 102976. December 2022

Suicide nanoplasmids coding for ribosome-inactivating proteins.
Mitdank, H. and Tröger, M. and Sonntag, A. and Shirazi, N.A. and Woith, E. and Fuchs, H. and Kobelt, D. and Walther, W. and Weng, A.
European Journal of Pharmaceutical Sciences 170 : 106107. 1 March 2022

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R. and Rautenstrauch, P. and Ghanbari, M. and James, A.R. and Kirchler, M. and Ohler, U. and Konigorski, S. and Lippert, C.
Nature Communications 13 (1): 5332. 10 September 2022

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R. and Rautenstrauch, P. and Ghanbari, M. and James, A.R. and Ohler, U. and Konigorski, S. and Lippert, C.
bioRxiv : 2021.05.27.444972. 20 January 2022

Immune cell C/EBPβ deficiency is associated with hepatic mononuclear defects and spontaneous hepatitis but not steatohepatitis induced liver fibrosis.
Moshkovits, I. and Kaminitz, A. and Reuveni, D. and Pasmanik-Chor, M. and Brazowski, E. and Mildner, A. and Leutz, A. and Zigmond, E.
Immunity, inflammation and disease 10 (11): e728. November 2022

Standardized annotation of translated open reading frames.
Mudge, J.M. and Ruiz-Orera, J. and Prensner, J.R. and Brunet, M.A. and Calvet, F. and Jungreis, I. and Gonzalez, Jo.M. and Magrane, M. and Martinez, T.F. and Schulz, J.F. and Yang, Y.T. and Albà, M.M. and Aspden, J.L. and Baranov, P.V. and Bazzini, A.A. and Bruford, E. and Martin, M.J. and Calviello, L. and Carvunis, A.R. and Chen, J. and Couso, J.P. and Deutsch, E.W. and Flicek, P. and Frankish, A. and Gerstein, M. and Hubner, N. and Ingolia, N.T. and Kellis, M. and Menschaert, G. and Moritz, R.L. and Ohler, U. and Roucou, X. and Saghatelian, A. and Weissman, J.S. and van Heesch, S.
Nature Biotechnology 40 (7): 994–999. July 2022

Deep Visual Proteomics defines single-cell identity and heterogeneity.
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Nature Biotechnology 40 (8): 1231-1240. August 2022

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
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Nature Communications 13 (1): 1009. 23 February 2022

Gene gun Her2/neu DNA vaccination: evaluation of vaccine efficacy in a syngeneic Her2/neu mouse tumor model.
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Generation of a NES-mScarlet red fluorescent reporter human iPSC line for live cell imaging and flow cytometric analysis and sorting using CRISPR-Cas9-mediated gene editing.
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Cells 11 (2): 268. 13 January 2022

Familial long-read sequencing increases yield of de novo mutations.
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American Journal of Human Genetics 109 (4): 631-646. 7 April 2022

Exercise blood-drop metabolic profiling links metabolism with perceived exertion.
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Frontiers in Molecular Biosciences 9 : 1042231. 21 December 2022

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
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EMBO Journal 41 (20): e110871. 17 October 2022

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance.
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Biochemical Society Transactions 50 (6): 1911-1920. December 2022

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
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Mitochondrial DNA mutations as natural barcodes for lineage tracing of murine tumor models.
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Cancer Research 5 December 2022 (In Press)

Treatment with ribociclib shows favourable immunomodulatory effects in patients with hormone receptor-positive breast cancer-findings from the RIBECCA trial.
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European Journal of Cancer 162 : 45-55. February 2022

A RAS-independent biomarker panel to reliably predict response to MEK inhibition in colorectal cancer.
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Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.
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The rate of spontaneous mutations in yeast deficient for MutSβ function.
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Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
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Genome Biology 23 (1): 193. 12 September 2022

Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
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The role of CD4 T cells in rejection of solid tumors.
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Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
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Long-term imaging reveals behavioral plasticity during C. elegans dauer exit.
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BMC Biology 20 (1): 277. 13 December 2022

Long-term imaging reveals behavioral plasticity during C. elegans dauer exit.
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bioRxiv : 2022.04.25.489360v1. 26 April 2022

Targeting Wnt/β-catenin signaling by TET1/FOXO4 inhibits metastatic spreading and self-renewal of cancer stem cells in gastric cancer.
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The genomic and transcriptional landscape of primary central nervous system lymphoma.
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Nature Communications 13 (1): 2558. 10 May 2022

Cellular hierarchies predict drug response in acute myeloid leukemia.
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Cancer Cell 40 (9): 917-919. 12 September 2022

FIRE-9 - PORT / AIO-KRK-0418: a prospective, randomized, open, multicenter Phase III trial to investigate the efficacy of adjuvant/additive chemotherapy in patients with definitely-treated metastatic colorectal cancer.
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BMC Cancer 22 (1): 359. 2 April 2022

A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
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Molecular Biology and Evolution 39 (10): msac175. October 2022

Liam tackles complex multimodal single-cell data integration challenges.
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Intricacies of single-cell multi-omics data integration.
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Trends in Genetics 38 (2): 128-139. February 2022

Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species.
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Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 10 May 2022 (In Press)

EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
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Comparison of FACS and PCR for detection of BCMA-CAR-T cells.
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International Journal of Molecular Sciences 23 (2): 903. 14 January 2022

The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.
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TCR gene therapy for cancer.
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90-yttrium-ibritumomab tiuxetan as first-line treatment for follicular lymphoma: updated efficacy and safety results at an extended median follow-up of 9.6 years.
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Annals of Hematology 101 (4): 781-788. April 2022

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
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Cell 185 (20): 3689-3704. 29 September 2022

JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia.
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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
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Nature Biotechnology 40 (12): 1845-1854. December 2022

CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
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Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
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Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
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Nature Immunology 23 (11): 1551-1563. November 2022

KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in Plasmodium falciparum-infected erythrocytes.
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Molecular Microbiology 117 (2): 274-292. February 2022

Identification of environmental factors that promote intestinal inflammation.
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Nature 611 (7937): 801-809. 24 November 2022

A knowledge graph to interpret clinical proteomics data.
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Nature Biotechnology 40 (5): 692-702. 22 May 2022

Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma.
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Journal of Cancer Research and Clinical Oncology 10 June 2022 (In Press)

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
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Nature Communications 13 (1): 281. 12 January 2022

Capillary gel electrophoresis (CGE) for quality control of plasmid DNA in gene therapy: quality control of 20 years stored GMP-grade plasmid DNA.
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Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker.
Schmid, F. and Dahlmann, M. and Röhrich, H. and Kobelt, D. and Hoffmann, J. and Burock, S. and Walther, W. and Stein, U.
British Journal of Cancer 127 (4): 675-685. 1 September 2022

B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
Schmid, V.K. and Khadour, A. and Ahmed, N. and Brandl, C. and Nitschke, L. and Rajewsky, K. and Jumaa, H. and Hobeika, E.
Haematologica 107 (8): 1796-1814. August 2022

Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma.
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Acute left ventricular insufficiency in a Burkitt Lymphoma patient with myocardial involvement and extensive local tumor cell lysis: a case report.
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BMC Cardiovascular Disorders 22 (1): 31. 4 February 2022

COVID-19: new disease mechanism is simultaneously a therapeutic target.
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COVID-19 and cellular senescence.
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Senescence and cancer - role and therapeutic opportunities.
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Nature Reviews Clinical oncology 19 (10): 619–636. October 2022

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
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Blood 139 (7): 1080-1097. 17 February 2022

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours.
Schubert, N.A. and Chen, C.Y. and Rodríguez, A. and Koster, J. and Dowless, M. and Pfister, S.M. and Shields, D.J. and Stancato, L.F. and Vassal, G. and Caron, H.N. and van den Boogaard, M.L. and Henssen, A.G. and Molenaar, J.J.
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Helicobacter pylori - neue Aspekte kommender Leitlinien [Helicobacter pylori - new aspects of forthcoming guidelines].
Schulz, C. and Fischbach, W. and Sigal, M. and Schütte, K. and Suerbaum, S. and Malfertheiner, P.
Internist 63 (4): 367–371. 1 March 2022

Evidence of neural crest cell origin of a DICER1 mutant CNS sarcoma in a child with DICER1 syndrome and NRAS-mutant neurocutaneous melanosis.
Schweizer, L. and Hartmann, W. and Koch, A. and Nunninger, M. and Thomale, U.W. and Pennacchietti, V. and Tietze, A. and Horn, D. and Pajtler, K.W. and Hirsch, S. and Wieland, I. and Deubzer, H. and Rossi, R. and Hernáiz Driever, P. and von Hoff, K. and von Zezschwitz, B.
Neuropathology and Applied Neurobiology 48 (6): e12830. October 2022

A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.
Shahan, R. and Hsu, C.W. and Nolan, T.M. and Cole, B.J. and Taylor, I.W. and Greenstreet, L. and Zhang, S. and Afanassiev, A. and Vlot, A.H.C. and Schiebinger, G. and Benfey, P.N. and Ohler, U.
Developmental Cell 57 (4): 543-560. 28 February 2022

K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation.
Shearer, R.F. and Typas, D. and Coscia, F. and Schovsbo, S. and Kruse, T. and Mund, A. and Mailand, N.
EMBO Journal 41 (9): e110145. 2 May 2022

Graph neural networks for learning molecular excitation spectra.
Singh, K. and Münchmeyer, J. and Weber, L. and Leser, U. and Bande, A.
Journal of Chemical Theory and Computation 18 (7): 4408-4417. 12 July 2022

A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish.
Singh, S.P. and Chawla, P. and Hnatiuk, A. and Kamel, M. and Silva, L.D. and Spanjaard, B. and Eski, S.E. and Janjuha, S. and Olivares-Chauvet, P. and Kayisoglu, O. and Rost, F. and Bläsche, J. and Kränkel, A. and Petzold, A. and Kurth, T. and Reinhardt, S. and Junker, J.P. and Ninov, N.
Development 149 (2): dev199853. January 2022

A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish.
Singh, S.P. and Chawla, P. and Hnatiuk, A. and Kamel, M. and Silva, L.D. and Spanjard, B. and Eski, S.E. and Janjuha, S. and Olivares, P. and Kayisoglu, O. and Rost, F. and Bläsche, J. and Kränkel, A. and Petzold, A. and Kurth, T. and Reinhardt, S. and Junker, J.P. and Ninov, N.
bioRxiv : 2021.06.24.449704. 31 January 2022

Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy.
Sinha Ray, S. and Dutta, D. and Dennys, C. and Powers, S. and Roussel, F. and Lisowski, P. and Glažar, P. and Zhang, X. and Biswas, P. and Caporale, J.R. and Rajewsky, N. and Bickle, M. and Wein, N. and Bellen, H.J. and Likhite, S. and Marcogliese, P.C. and Meyer, K.C.
Cell Reports 41 (10): 111751. 6 December 2022

CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment.
Skroblyn, T. and Joedicke, J.J. and Pfau, M. and Krüger, K. and Bourquin, J.P. and Izraeli, S. and Eckert, C. and Höpken, U.E.
Journal of Pathology 258 (1): 12-25. September 2022

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors.
Specker, E. and Matthes, S. and Wesolowski, R. and Schütz, A. and Grohmann, M. and Alenina, N. and Pleimes, D. and Mallow, K. and Neuenschwander, M. and Gogolin, A. and Weise, M. and Pfeifer, J. and Ziebart, N. and Heinemann, U. and von Kries, J.P. and Nazaré, M. and Bader, M.
Journal of Medicinal Chemistry 65 (16): 11126-11149. 25 August 2022

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas.
Staudacher, J.J. and Arnold, A. and Kühl, A.A. and Pötzsch, M. and Daum, S. and Winterfeld, M. and Berg, E. and Hummel, M. and Rau, B. and Stein, U. and Treese, C.
BMC Cancer 22 (1): 953. 5 September 2022

DLBCL 1L-what to expect beyond R-CHOP?
Stegemann, M. and Denker, S. and Schmitt, C.A.
Cancers 14 (6): 1453. 11 March 2022

Editorial: Mitochondria as a hub in cellular signaling.
Stoolman, J.S. and Porcelli, A.M. and Martínez-Reyes, I.
Frontiers in Cell and Developmental Biology 10 : 981464. 15 August 2022

Comorbidities rather than older age define outcome in adult patients with tumors of the Ewing sarcoma family.
Striefler, J.K. and Schmiester, M. and Brandes, F. and Dörr, A. and Pahl, S. and Kaul, D. and Rau, D. and Dobrindt, E.M. and Koulaxouzidis, G. and Bullinger, L. and Märdian, S. and Flörcken, A.
Cancer Medicine 11 (17): 3213-3225. September 2022

MCT1 is a predictive marker for lenalidomide maintenance therapy in multiple myeloma.
Stroh, J. and Seckinger, A. and Heider, M. and Rudelius, M. and Eichner, R. and Schick, M. and Slawska, J. and Emde, M. and Salwender, H. and Bertsch, U. and Goldschmidt, H. and Weisel, K.C. and Scheid, C. and Keller, U. and Hose, D. and Bassermann, F.
Blood Advances 6 (2): 515-520. 25 January 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S. and Busch, C.J.L. and Molawi, K. and Geirsdottir, L. and Maurizio, J. and Vargas Aguilar, S. and Belahbib, H. and Gimenez, G. and Yuda, R.A.A. and Burkon, M. and Favret, J. and Gholamhosseinian Najjar, S. and de Laval, B. and Kandalla, P.K. and Sarrazin, S. and Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23 (3): 458-468. March 2022

The landscape of genetic aberrations in myxofibrosarcoma.
Takeuchi, Y. and Yoshida, K. and Halik, A. and Kunitz, A. and Suzuki, H. and Kakiuchi, N. and Shiozawa, Y. and Yokoyama, A. and Inoue, Y. and Hirano, T. and Yoshizato, T. and Aoki, K. and Fujii, Y. and Nannya, Y. and Makishima, H. and Pfitzner, B.M. and Bullinger, L. and Hirata, M. and Jinnouchi, K. and Shiraishi, Y. and Chiba, K. and Tanaka, H. and Miyano, S. and Okamoto, T. and Haga, H. and Ogawa, S. and Damm, F.
International Journal of Cancer 151 (4): 565-577. 15 August 2022

Concomitant cytotoxic effector differentiation of CD4(+) and CD8(+) T cells in response to EBV-Infected B cells.
Tamura, Y. and Yamane, K. and Kawano, Y. and Bullinger, L. and Wirtz, T. and Weber, T. and Sander, S. and Ohki, S. and Kitajima, Y. and Okada, S. and Rajewsky, K. and Yasuda, T.
Cancers 14 (17): 4118. 25 August 2022

Unified classification and risk-stratification in Acute Myeloid Leukemia.
Tazi, Y. and Arango-Ossa, J.E. and Zhou, Y. and Bernard, E. and Thomas, I. and Gilkes, A. and Freeman, S. and Pradat, Y. and Johnson, S.J. and Hills, R. and Dillon, R. and Levine, M.F. and Leongamornlert, D. and Butler, A. and Ganser, A. and Bullinger, L. and Döhner, K. and Ottmann, O. and Adams, R. and Döhner, H. and Campbell, P.J. and Burnett, A.K. and Dennis, M. and Russell, N.H. and Devlin, S.M. and Huntly, B.J.P. and Papaemmanuil, E.
Nature Communications 13 (1): 4622. 8 August 2022

Genomic evolution and personalized therapy of an infantile fibrosarcoma harboring an NTRK oncogenic fusion.
Thorwarth, A. and Haase, K. and Röefzaad, C. and Pajtler, K.W. and Schramm, K. and Hauptmann, K. and Behnke, A. and Vokuhl, C. and Elgeti, T. and Gratopp, A. and Schulte, J.H. and Scheer, M. and Hernáiz Driever, P. and Nysom, K. and Eggert, A. and Henssen, A.G. and Deubzer, H.E.
JCO Precision Oncology 6 : e2100283. 25 May 2022

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. and Danner, E. and Li, X. and Graf, R. and Lebedin, M. and de la Rosa, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022

S100A4 is a strong negative prognostic marker and potential therapeutic target in adenocarcinoma of the stomach and esophagus.
Treese, C. and Hartl, K. and Pötzsch, M. and Dahlmann, M. and von Winterfeld, M. and Berg, E. and Hummel, M. and Timm, L. and Rau, B. and Walther, W. and Daum, S. and Kobelt, D. and Stein, U.
Cells 11 (6): 1056. 21 March 2022

Inhibition of MACC1-induced metastasis in esophageal and gastric adenocarcinomas.
Treese, C. and Werchan, J. and von Winterfeld, M. and Berg, E. and Hummel, M. and Timm, L. and Rau, B. and Daberkow, O. and Walther, W. and Daum, S. and Kobelt, D. and Stein, U.
Cancers 14 (7): 1773. 31 March 2022

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells.
Trumpp, A. and Haas, S.
Cell 185 (8): 1266-1270. 14 April 2022

ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.
Tsybulskyi, V. and Meyer, I.M.
Nucleic Acids Research 50 (15): e85. 26 August 2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B. and Lazarow, K. and Kolesnichenko, M. and Sporbert, A. and von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

Time-keeping and decision-making in living cells: Part II.
Tyson, J.J. and Csikasz-Nagy, A. and Gonze, D. and Kim, J.K. and Santos, S. and Wolf, J.
Interface Focus 12 (4): 20220024. 10 June 2022

Time-keeping and decision-making in living cells: Part I.
Tyson, J.J. and Csikasz-Nagy, A. and Gonze, D. and Kim, J.K. and Santos, S. and Wolf, J.
Interface Focus 12 (3): 20220011. 6 June 2022

Detection and validation of circular DNA fragments using nanopore sequencing.
Tüns, A.I. and Hartmann, T. and Magin, S. and Chamorro González, R. and Henssen, A.G. and Rahmann, S. and Schramm, A. and Köster, J.
Frontiers in Genetics 13 : 867018. 30 May 2022

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Ventura, P.M.O. and Gakovic, M. and Fischer, B.A. and Spinelli, L. and Rota, G. and Pathak, S. and Khameneh, H.J. and Zenobi, A. and Thomson, S. and Birchmeier, W. and Cantrell, D.A. and Guarda, G.
EMBO Reports 23 (11): e55399. 7 November 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H. and Dauksaite, V. and Sporbert, A. and Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083.e8. 2 June 2022

The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
Viñado, A.C. and Calvo, I.A. and Cenzano, I. and Olaverri, D. and Cocera, M. and San Martin-Uriz, P. and Romero, J.P. and Vilas-Zornoza, A. and Vera, L. and Gomez-Cebrian, N. and Puchades-Carrasco, L. and Lisi-Vega, L.E. and Apaolaza, I. and Valera, P. and Guruceaga, E. and Granero-Molto, F. and Ripalda-Cemborain, P. and Luck, T.J. and Bullinger, L. and Planes, F.J. and Rifon, J.J. and Méndez-Ferrer, S. and Yusuf, R.Z. and Pardo-Saganta, A. and Prosper, F. and Saez, B.
Leukemia 36 (8): 1969-1979. August 2022

Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C. and Maghsudi, S. and Ohler, U.
Nucleic Acids Research 50 (18): e107. 14 October 2022

Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival.
Vuaroqueaux, V. and Musch, A. and Kobelt, D. and Risch, T: and Herrmann, P. and Burock, S. and Peille, A.L. and Yaspo, M.L. and Fiebig, H.H. and Stein, U.
Cancers 14 (7): 1749. 1 April 2022

A peculiar case of primary central nervous system T-cell lymphoma with indolent behavior.
Wasilewski, D. and Janz, M. and Koch, A. and Rosenwald, A. and Keller, U. and Vajkoczy, P. and Faust, K. and Anagnostopoulos, I. and Radke, J.
Acta Neurologica Belgica 2 April 2022 (In Press)

Chemical-protein relation extraction with ensembles of carefully tuned pretrained language models.
Weber, L. and Sänger, M. and Garda, S. and Barth, F. and Alt, C. and Leser, U.
Database 2022 : baac098. 18 November 2022

Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C. and Lammoglia Cobo, M.F. and Stein, C.A. and Hsu, M.T. and Ben Hamza, A. and Penter, L. and Chen, X. and Buccitelli, C. and Popp, O. and Mertins, P. and Dietze, K. and Bullinger, L. and Moosmann, A. and Blanc, E. and Beule, D. and Gerbitz, A. and Strobel, J. and Hackstein, H. and Rahn, H.P. and Dornmair, K. and Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10 (11): 1407-1419. 1 November 2022

Precision medicine in myeloid malignancies.
Westermann, J. and Bullinger, L.
Seminars in Cancer Biology 84 : 153-169. September 2022

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke, A.C. and Doebele, C. and Zindel, A. and Lee, K.S. and Rieke, S.A. and Ceribelli, M. and Comoglio, F. and Phelan, J.D. and Wang, J.Q. and Pikman, Y. and Jahn, D. and Häupl, B. and Schneider, C. and Scheich, S. and Tosto, F.A. and Bohnenberger, H. and Stauder, P. and Schnütgen, F. and Slabicki, M. and Coulibaly, Z.A. and Wolf, S. and Bojarczuk, K. and Chapuy, B. and Brandts, C.H. and Stroebel, P. and Lewis, C.A. and Engelke, M. and Xu, X. and Kim, H. and Dang, T.H. and Schmitz, R. and Hodson, D.J. and Stegmaier, K. and Urlaub, H. and Serve, H. and Schmitt, C.A. and Kreuz, F. and Knittel, G. and Rabinowitz, J.D. and Reinhardt, H.C. and Vander Heiden, M.G. and Thomas, C. and Staudt, L.M. and Zenz, T. and Oellerich, T.
Blood 139 (4): 538-553. 27 January 2022

Long-term observation of the frequency of secondary colorectal cancer and other malignancies in tyrosine kinase inhibitor treated chronic myeloid leukemia patients and controls.
Winkelmann, N. and Schwarz, M. and Hildebrandt, B. and Henke, O. and Bullinger, L. and Na, I.K. and Stintzing, S. and le Coutre, P.
eJHaem: The Official Journal of the British Society for Haematology 3 (3): 949-953. August 2022

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A. and Bunse, M. and Joedicke, J.J. and Blanc, E. and Gudipati, V. and Moles, M.W. and Shiku, H. and Beule, D. and Huppa, J.B. and Höpken, U.E. and Rehm, A.
Molecular Therapy 30 (11): 3358-3378. 2 November 2022

Paired donor and recipient immunophenotyping in allogeneic hematopoietic stem cell transplantation: a cellular network approach.
Wittenbecher, F. and Lesch, S. and Kolling, S. and Blau, I.W. and Vuong, L. and Borchert, F. and Movasshagi, K. and Tietze-Bürger, C. and Penack, O. and Ahn, J. and Bullinger, L. and Frentsch, M. and Na, I.K.
Frontiers in Immunology 13 : 874499. 23 May 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J. and Müllerke, S. and Kolesnichenko, M. and Heuberger, J. and Lin, M. and Fischer, A.S. and Mollenkopf, H.J. and Berger, H. and Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

Radiofrequency electromagnetic fields cause non-temperature-induced physical and biological effects in cancer cells.
Wust, P. and Veltsista, P.D. and Oberacker, E. and Yavvari, P. and Walther, W. and Bengtsson, O. and Sterner-Kock, A. and Weinhart, M. and Heyd, F. and Grabowski, P. and Stintzing, S. and Heinrich, W. and Stein, U. and Ghadjar, P.
Cancers 14 (21): 5349. 30 October 2022

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler, E. and Adler, J.M. and Eschke, K. and Teixeira Alves, G. and Peidli, S. and Pott, F. and Kazmierski, J. and Michalick, L. and Kershaw, O. and Bushe, J. and Andreotti, S. and Pennitz, P. and Abdelgawad, A. and Postmus, D. and Goffinet, C. and Kreye, J. and Reincke, S.M. and Prüss, H. and Blüthgen, N. and Gruber, A.D. and Kuebler, W.M. and Witzenrath, M. and Landthaler, M. and Nouailles, G. and Trimpert, J.
Molecular Therapy 30 (5): 1952-1965. 4 May 2022

Analysis of copy number variation in men with non-obstructive azoospermia.
Wyrwoll, M.J. and Wabschke, R. and Röpke, A. and Wöste, M. and Ruckert, C. and Perrey, S. and Rotte, N. and Hardy, J. and Astica, L. and Lupianez, D.G. and Wistuba, J. and Westernströer, B. and Schlatt, S. and Berman, A.J. and Müller, A.M. and Kliesch, S. and Yatsenko, A.N. and Tüttelmann, F. and Friedrich, C.
Andrology 10 (8): 1593-1604. November 2022

Application of precision medicine in clinical routine in haematology - challenges and opportunities.
Wästerlid, T. and Cavelier, L. and Haferlach, C. and Konopleva, M. and Fröhling, S. and Östling, P. and Bullinger, L. and Fioretos, T. and Smedby, K.E.
Journal of Internal Medicine 292 (2): 243-261. August 2022

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y. and Du Jiang, P. and Chao, B.N. and Cagdas, D. and Kubo, S. and Balasubramaniyam, A. and Zhang, Y. and Shadur, B. and NaserEddin, A. and Folio, L.R. and Schwarz, B. and Bohrnsen, E. and Zheng, L. and Lynberg, M. and Gottlieb, S. and Leney-Greene, M.A. and Park, A.Y. and Tezcan, I. and Akdogan, A. and Gocmen, R. and Onder, S. and Rosenberg, A. and Soilleux, E.J. and Johnson, E. and Jackson, P.K. and Demeter, J. and Chauvin, S.D. and Paul, F. and Selbach, M. and Bulut, H. and Clatworthy, M.R. and Tuong, Z.K. and Zhang, H. and Stewart, B.J. and Bosio, C.M. and Stepensky, P. and Clare, S. and Ganesan, S. and Pascall, J.C. and Daumke, O. and Butcher, G.W. and McMichael, A.J. and Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219 (6): e20201405. 6 June 2022

Extrachromosomal DNA amplifications in cancer.
Yi, E. and Chamorro González, R. and Henssen, A.G. and Verhaak, R.G.W.
Nature Reviews Genetics 23 (12): 760-771. December 2022

Analysis of single-cell transcriptome data in drosophila.
Yousefian, S. and Musillo, M.J. and Bageritz, J.
In: Drosophila. Methods in Molecular Biology, 2540 (3). Springer / Humana Press, New York, NY, USA, 93-111. ISBN 9781071625408 19 August 2022

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.
Zhai, Y. and Singh, P. and Dolnik, A. and Brazda, P. and Atlasy, N. and Del Gaudio, N. and Döhner, K. and Döhner, H. and Minucci, S. and Martens, J. and Altucci, L. and Megchelenbrink, W. and Bullinger, L. and Stunnenberg, H.G.
Molecular Cancer 21 (1): 166. 19 August 2022

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19.
Zhang, B. and Zhang, Z. and Koeken, V.A.C.M. and Kumar, S. and Aillaud, M. and Tsay, H.C. and Liu, Z. and Kraft, A.R.M. and Soon, C.F. and Odak, I. and Bošnjak, B. and Vlot, A. and Swertz, M.A. and Ohler, U. and Geffers, R. and Illig, T. and Huehn, J. and Saliba, A.E. and Sander, L.E. and Förster, R. and Xu, C.J. and Cornberg, M. and Schulte, L.N. and Li, Y.
Cell Genomics : 100232. 2 December 2022 (In Press)

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U. and Milek, M. and Minia, I. and Vieira-Vieira, C.H. and Müller, S. and Mastrobuoni, G. and Hazapis, O.G. and Del Giudice, S. and Schwefel, D. and Bley, N. and Voigt, F. and Chao, J.A. and Kempa, S. and Hüttelmaier, S. and Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G. and Vanzo, R. and Amitash, S. and Martín-Doncel, E. and Coscia, F. and Mund, A. and Lerdrup, M. and Benada, J. and Boos, D. and Toledo, L.
Molecular Cell 82 (18): 3350-3365. 15 September 2022

SMOG 2 and OpenSMOG: extending the limits of structure-based models.
de Oliveira, A.B. and Contessoto, V.G. and Hassan, A. and Byju, S. and Wang, A. and Wang, Y. and Dodero-Rojas, E. and Mohanty, U. and Noel, J.K. and Onuchic, J.N. and Whitford, P.C.
Protein Science 31 (1): 158-172. January 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E. and Brückner, L. and Henssen, A.G.
Nature Genetics 54 (2): 107-114. February 2022

Soluble urokinase plasminogen activator receptor levels are associated with severity of fibrosis in patients with primary sclerosing cholangitis.
Özdirik, B. and Maibier, M. and Scherf, M. and Nicklaus, J.M. and Frohme, J. and Puengel, T. and Meyer Zum Büschenfelde, D. and Tacke, F. and Mueller, T. and Sigal, M.
Journal of Clinical Medicine 11 (9): 2479. 28 April 2022

2021

Metastasis : methods and protocols.
Stein, U.S., ed.
Methods in Molecular Biology, 2294 . Springer / Humana Press, New York, NY. ISBN 978-1-0716-1349-8 2021

From operating table to laboratory bench: the path toward metastasis research from the clinical setting.
Alberto Vilchez, M. and Rau, B.
Methods in Molecular Biology 2294 : 325-333. 2021

Spontaneous non-sustained ventricular tachycardia and premature ventricular contractions and their prognostic relevance in patients with cancer in routine care.
Albrecht, A. and Porthun, J. and Eucker, J. and Coats, A.J.S. and von Haehling, S. and Pezzutto, A. and Karakas, M. and Riess, H. and Keller, U. and Landmesser, U. and Haverkamp, W. and Anker, S.D. and Anker, M.S.
Cancers 13 (10): 2303. 12 May 2021

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. and Acemel, R.D. and Jedamzick, J. and Bolondi, A. and Cova, G. and Brieske, N. and Kuehn, R. and Wittler, L. and Real, F.M. and Lupianez, D.G.
bioRxiv : 2021.04.14.439779. 14 April 2021

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt, B. and Mastrobuoni, G. and Wuenschel, J. and Astrahantseff, K. and Eggert, A. and Kempa, S. and Deubzer, H.E.
Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1): 1282-1289. 30 June 2021

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, B. and Zasada, C. and Baum, K. and Wuenschel, J. and Mastrobuoni, G. and Lodrini, M. and Astrahantseff, K. and Winkler, A. and Schulte, J.H. and Finkler, S. and Forbes, M. and Hundsdoerfer, P. and Guergen, D. and Hoffmann, J. and Wolf, J. and Eggert, A. and Kempa, S. and Deubzer, H.E.
International Journal of Cancer 148 (5): 1219-1232. 1 March 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Aslam, M.A. and Alemdehy, M.F. and Kwesi-Maliepaard, E.M. and Muhaimin, F.I. and Caganova, M. and Pardieck, I.N. and van den Brand, T. and van Welsem, T. and de Rink, I. and Song, J.Y. and de Wit, E. and Arens, R. and Jacobs, H. and van Leeuwen, F.
EMBO Reports 22 (2): e51184. 3 February 2021

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P. and Song, T. and Yao, Y. and Fehlner-Peach, H. and Diamond, B. and Gu, H. and Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118 (30): e2100576118. 27 July 2021

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions.
Bassani, B. and Tripodo, C. and Portararo, P. and Gulino, A. and Botti, L. and Chiodoni, C. and Jachetti, E. and Bolli, N. and Ciciarello, M. and Joehrens, K. and Anagnostopoulos, I. and Na, I.K. and Curti, A. and Colombo, M.P. and Sangaletti, S.
Frontiers in Immunology 12 : 662048. 18 May 2021

Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham, R. and Litchfield, K. and Watkins, T.B.K. and Lim, E.L. and Rosenthal, R. and Martínez-Ruiz, C. and Hiley, C.T. and Bakir, M.A. and Salgado, R. and Moore, D.A. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature 597 (7877): 555-560. 23 September 2021

Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography.
Berger, C. and Ravelli, R.B.G. and López-Iglesias, C. and Kudryashev, M. and Diepold, A. and Peters, P.J.
Journal of Structural Biology 213 (1): 107701. March 2021

Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki, P. and Riesenfeld, S.J. and Hütter, J.C. and Torlai Triglia, E. and Kowalczyk, M.S. and Ricardo-Gonzalez, R.R. and Lian, M. and Amezcua Vesely, M.C. and Kroehling, L. and Xu, H. and Slyper, M. and Muus, C. and Ludwig, L.S. and Christian, E. and Tao, L. and Kedaigle, A.J. and Steach, H.R. and York, A.G. and Skadow, M.H. and Yaghoubi, P. and Dionne, D. and Jarret, A. and McGee, H.M. and Porter, C.B.M. and Licona-Limón, P. and Bailis, W. and Jackson, R. and Gagliani, N. and Gasteiger, G. and Locksley, R.M. and Regev, A. and Flavell, R.A.
Nature 592 (7852): 128-132. 1 April 2021

SARS-CoV-2 in humans.
Binder, M. and Wyler, E.
Berliner und Munchener Tierarztliche Wochenschrift 134 : 1-13. 30 April 2021

A resource of targeted mutant mouse lines for 5,061 genes.
Birling, M.C. and Yoshiki, A. and Adams, D.J. and Ayabe, S. and Beaudet, A.L. and Bottomley, J. and Bradley, A. and Brown, S.D.M. and Bürger, A. and Bushell, W. and Chiani, F. and Chin, H.J.G. and Christou, S. and Codner, G.F. and DeMayo, F.J. and Dickinson, M.E. and Doe, B. and Donahue, L.R. and Fray, M.D. and Gambadoro, A. and Gao, X. and Gertsenstein, M. and Gomez-Segura, A. and Goodwin, L.O. and Heaney, J.D. and Hérault, Y. and de Angelis, M.H. and Jiang, S.T. and Justice, M.J. and Kasparek, P. and King, R.E. and Kühn, R. and Lee, H. and Lee, Y.J. and Liu, Z. and Lloyd, K.C.K. and Lorenzo, I. and Mallon, A.M. and McKerlie, C. and Meehan, T.F. and Fuentes, V.M. and Newman, S. and Nutter, L.M.J. and Oh, G.T. and Pavlovic, G. and Ramirez-Solis, R. and Rosen, B. and Ryder, E.J. and Santos, L.A. and Schick, J. and Seavitt, J.R. and Sedlacek, R. and Seisenberger, C. and Seong, J.K. and Skarnes, W.C. and Sorg, T. and Steel, K.P. and Tamura, M. and Tocchini-Valentini, G.P. and Wang, C.K.L. and Wardle-Jones, H. and Wattenhofer-Donzé, M. and Wells, S. and Wiles, M.V. and Willis, B.J. and Wood, J.A. and Wurst, W. and Xu, Y. and Teboul, L. and Murray, S.A.
Nature Genetics 53 (4): 416-419. April 2021

Cerebral EBV-positive PTLD controlled by PD-1 checkpoint blockade in a liver transplant patient.
Bittner, A. and Radke, J. and Eurich, D. and Wiener, E. and Denker, S. and Anagnostopoulos, I. and Na, I.K. and Heppner, F.L. and Bullinger, L. and Schmitt, C.A.
Leukemia & Lymphoma 62 (8): 2026-2029. August 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Bloehdorn, J. and Braun, A. and Taylor-Weiner, A. and Jebaraj, B.M.C. and Robrecht, S. and Krzykalla, J. and Pan, H. and Giza, A. and Akylzhanova, G. and Holzmann, K. and Scheffold, A. and Johnston, H.E. and Yeh, R.F. and Klymenko, T. and Tausch, E. and Eichhorst, B. and Bullinger, L. and Fischer, K. and Weisser, M. and Robak, T. and Schneider, C. and Gribben, J. and Dahal, L.N. and Carter, M.J. and Elemento, O. and Landau, D.A. and Neuberg, D.S. and Cragg, M.S. and Benner, A. and Hallek, M. and Wu, C.J. and Döhner, H. and Stilgenbauer, S. and Mertens, D.
Nature Communications 12 (1): 5395. 13 September 2021

Gene expression profiling predicts sensitivity of chronic lymphocytic leukemia cells to dasatinib.
Blätte, T.J. and Machnicki, M.M. and Glodkowska-Mrowka, E. and Dolnik, A. and Karp, M. and Karczmarczyk, A. and Giannopoulos, K. and Bullinger, L. and Stoklosa, T.
HemaSphere 5 (1): e514. January 2021

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma.
Bohl, S.R. and Schmalbrock, L.K. and Bauhuf, I. and Meyer, T. and Dolnik, A. and Szyska, M. and Blätte, T.J. and Knödler, S. and Röhner, L. and Miller, D. and Kull, M. and Langer, C. and Döhner, H. and Letai, A. and Damm, F. and Heckl, D. and Bullinger, L. and Krönke, J.
Blood Advances 5 (9): 2391-2402. 11 May 2021

PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial.
Borchmann, P. and Plütschow, A. and Kobe, C. and Greil, R. and Meissner, J. and Topp, M.S. and Ostermann, H. and Dierlamm, J. and Mohm, J. and Thiemer, J. and Sökler, M. and Kerkhoff, A. and Ahlborn, M. and Halbsguth, T.V. and Martin, S. and Keller, U. and Balabanov, S. and Pabst, T. and Vogelhuber, M. and Hüttmann, A. and Wilhelm, M. and Zijlstra, J.M. and Moccia, A. and Kuhnert, G. and Bröckelmann, P.J. and von Tresckow, B. and Fuchs, M. and Klimm, B. and Rosenwald, A. and Eich, H. and Baues, C. and Marnitz, S. and Hallek, M. and Diehl, V. and Dietlein, M. and Engert, A.
Lancet Oncology 22 (2): 223-234. February 2021

Impact of a specialised palliative care intervention in patients with advanced soft tissue sarcoma - a single-centre retrospective analysis.
Brandes, F. and Striefler, J.K. and Dörr, A. and Schmiester, M. and Märdian, S. and Koulaxouzidis, G. and Kaul, D. and Behzadi, A. and Thuss-Patience, P. and Ahn, J. and Pelzer, U. and Bullinger, L. and Flörcken, A.
BMC Palliative Care 20 (1): 16. 14 January 2021

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
Breitkreuz-Korff, O. and Tscheik, C. and Del Vecchio, G. and Dithmer, S. and Walther, W. and Orthmann, A. and Wolburg, H. and Haseloff, R.F. and Schröder, L. and Blasig, I.E. and Winkler, L.
Journal of Controlled Release 330 : 137-148. 10 August 2021

Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo.
Briest, F. and Koziolek, E.J. and Albrecht, J. and Schmidt, F. and Bernsen, M.R. and Haeck, J. and Kühl, A.A. and Sedding, D. and Hartung, T. and Exner, S. and Welzel, M. and Fischer, C. and Grötzinger, C. and Brenner, W. and Baum, R.P. and Grabowski, P.
Neoplasia 23 (1): 80-98. January 2021

NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Brischetto, C. and Krieger, K. and Klotz, C. and Krahn, I. and Kunz, S. and Kolesnichenko, M. and Mucka, P. and Heuberger, J. and Scheidereit, C. and Schmidt-Ullrich, R.
Development 148 (21): dev199683. November 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann, J. and Lorenz, C. and Borchmann, S. and Nishii, K. and Wegner, J. and Meder, L. and Ostendorp, J. and Ast, D.F. and Heimsoeth, A. and Nakasuka, T. and Hirabae, A. and Okawa, S. and Dammert, M.A. and Plenker, D. and Klein, S. and Lohneis, P. and Gu, J. and Godfrey, L.K. and Forster, J. and Trajkovic-Arsic, M. and Zillinger, T. and Haarmann, M. and Quaas, A. and Lennartz, S. and Schmiel, M. and D'Rozario, J. and Thomas, E.S. and Li, H. and Schmitt, C.A. and George, J. and Thomas, R.K. and von Karstedt, S. and Hartmann, G. and Büttner, R. and Ullrich, R.T. and Siveke, J.T. and Ohashi, K. and Schlee, M. and Sos, M.L.
Nature Communications 12 (1): 5505. 17 September 2021

Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I. and Holler, K. and Appelbaum, L. and Eisenberg, E. and Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49 (8): 4325-4337. 7 May 2021

Structural evidence of active site adaptability towards different sized substrates of aromatic amino acid aminotransferase from Psychrobacter sp. B6.
Bujacz, A. and Rum, J. and Rutkiewicz, M. and Pietrzyk-Brzezinska, A.J. and Bujacz, G.
Materials 14 (12): 3351. 2 June 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

Non-coding RNAs: lncRNAs, miRNAs, and piRNAs in sexual development.
Burgos, M. and Hurtado, A. and Jiménez, R. and Barrionuevo, F.J.
Sexual Development 15 (5-6): 335-350. December 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K. and Kny, M. and Huang, N. and Klassert, T.E. and Stock, M. and Hahn, A. and Graeger, S. and Todiras, M. and Schmidt, S. and Chamling, B. and Willenbrock, M. and Groß, S. and Biedenweg, D. and Heuser, A. and Scheidereit, C. and Butter, C. and Felix, S.B. and Otto, O. and Luft, F.C. and Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Gene therapy "Made in Germany": a historical perspective, analysis of the status quo, and recommendations for action by the German Society for Gene Therapy.
Büning, H. and Fehse, B. and Ivics, Z. and Kochanek, S. and Koehl, U. and Kupatt, C. and Mussolino, C. and Nettelbeck, D.M. and Schambach, A. and Uckert, W. and Wagner, E. and Cathomen, T.
Human Gene Therapy 32 (19-20): 987-996. 18 October 2021

Single cell biology - a Keystone Symposia report.
Cable, J. and Elowitz, M.B. and Domingos, A.I. and Habib, N. and Itzkovitz, S. and Hamidzada, H. and Balzer, M.S. and Yanai, I. and Liberali, P. and Whited, J. and Streets, A. and Cai, L. and Stergachis, A.B. and Hong, C.K.Y. and Keren, L. and Guilliams, M. and Alon, U. and Shalek, A.K. and Hamel, R. and Pfau, S.J. and Raj, A. and Quake, S.R. and Zhang, N.R. and Fan, J. and Trapnell, C. and Wang, B. and Greenwald, N.F. and Vento-Tormo, R. and Santos, S.D.M. and Spencer, S.L. and Garcia, H.G. and Arekatla, G. and Gaiti, F. and Arbel-Goren, R. and Rulands, S. and Junker, J.P. and Klein, A.M. and Morris, S.A. and Murray, J.I. and Galloway, K.E. and Ratz, M. and Romeike, M.
Annals of the New York Academy of Sciences 1506 (1): 74-97. December 2021

Cancer stem cells: advances in biology and clinical translation -- a Keystone Symposia report.
Cable, J. and Pei, D. and Reid, L.M. and Wang, X.W. and Bhatia, S. and Karras, P. and Melenhorst, J.J. and Grompe, M. and Lathia, J.D. and Song, E. and Kuo, C.J. and Zhang, N. and White, R.M. and Ma, S.K. and Ma, L. and Chin, Y.R. and Shen, M.M. and Ng, I.O.L. and Kaestner, K.H. and Zhou, L. and Sikandar, S. and Schmitt, C.A. and Guo, W. and Wong, C.C.L. and Ji, J. and Tang, D.G. and Dubrovska, A. and Yang, C. and Wiedemeyer, W.R. and Weissman, I.L.
Annals of the New York Academy of Sciences 1506 (1): 142–163. December 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Wilkins, K. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49 (9): 5336-5350. May 2021

Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
Carley, L.N. and Mojica, J.P. and Wang, B. and Chen, C.Y. and Lin, Y.P. and Prasad, K.V.S.K and Chan, E. and Hsu, C.W. and Keith, R. and Nuñez, C.L. and Olson-Manning, C.F. and Rushworth, C.A. and Wagner, M.R. and Wang, J. and Yeh, P.M. and Reichelt, M. and Ghattas, K. and Gershenzon, J. and Lee, C.R. and Mitchell-Olds, T.
Nature Ecology & Evolution 5 : 1135–1144. August 2021

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer.
Carter, D.M. and Specker, E. and Malecki, P.H. and Przygodda, J. and Dudaniec, K. and Weiss, M.S. and Heinemann, U. and Nazaré, M. and Gohlke, U.
Journal of Medicinal Chemistry 64 (19): 14266-14282. 14 October 2021

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules.
Cipriani, P.G. and Bay, O. and Zinno, J. and Gutwein, M. and Gan, H.H. and Mayya, V.K. and Chung, G. and Chen, J.X. and Fahs, H. and Guan, Y. and Duchaine, T.F. and Selbach, M. and Piano, F. and Gunsalus, K.C.
eLife 10 : e60833. 3 August 2021

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules.
Cipriani, P.G. and Bay, O. and Zinno, J.P. and Gutwein, M. and Gan, H.H. and Mayya, V. and Chung, G. and Chen, J.X. and Fahs, H. and Guan, Y. and Duchaine, T. and Selbach, M. and Piano, F. and Gunsalus, K.
bioRxiv : 2021.06.17.448425. 17 June 2021

Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann, M. and Gambara, G. and Brzezicha, B. and Popp, O. and Pachmayr, E. and Wedeken, L. and Pflaume, A. and Mokritzkij, M. and Gül-Klein, S. and Brandl, A. and Schweiger-Eisbacher, C. and Mertins, P. and Hoffmann, J. and Keilholz, U. and Walther, W. and Regenbrecht, C. and Rau, B. and Stein, U.
Molecular Cancer 20 (1): 129. 21 October 2021

Combination of Wnt/β-catenin targets S100A4 and DKK1 improves prognosis of human colorectal cancer.
Dahlmann, M. and Monks, A. and Harris, E.D. and Kobelt, D. and Osterland, M. and Khaireddine, F. and Herrmann, P. and Kemmner, W. and Burock, S. and Walther, W. and Shoemaker, R.H. and Stein, U.
Cancers 14 (1): 37. 22 December 2021

A bioinformatic pipeline to identify biomarkers for metastasis formation from RNA sequencing data.
Dahlmann, M. and Stein, U.S.
Methods in Molecular Biology 2294 : 221-238. 2021

Early bilirubinemia after allogeneic stem cell transplantation - an endothelial complication.
Dai, H. and Penack, O. and Radujkovic, A. and Schult, D. and Majer-Lauterbach, J. and Blau, I.W. and Bullinger, L. and Jiang, S. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Bone Marrow Transplantation 56 (7): 1573-1583. July 2021

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. and Lebedin, M. and de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021

Thyrotropin receptor-specific lymphocytes in adenovirus-TSHR-immunized native and human leukocyte antigen-DR3-transgenic mice and in Graves' disease patient blood.
Degen, H. and Gavvovidis, I. and Blankenstein, T. and Uhland, K. and Ungerer, M.
Thyroid 31 (6): 950-963. June 2021

Elevated Flt3L predicts long-term survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.
Detjen, K.M. and Otto, R. and Giesecke, Y. and Geisler, L. and Riemer, P. and Jann, H. and Grötzinger, C. and Sers, C. and Pascher, A. and Lüdde, T. and Leser, U. and Wiedenmann, B. and Sigal, M. and Tacke, F. and Roderburg, C. and Hammerich, L.
Cancers 13 (17): 4463. 1 September 2021

„Liquid biopsies“ als neue Diagnostikplattform in der pädiatrischen Onkologie [Liquid biopsies as a new diagnostic platform in pediatric oncology].
Deubzer, H.E. and Eggert, A. and Pajtler, K. W.
Onkologe 27 (5): 458-463. May 2021

Personalisierte Medizin in der Kinderonkologie: Wo stehen wir heute?
Deubzer, H.E. and Schulte, J.H. and Eggert, A.
Pädiatrie up2date 16 (4): 325-342. December 2021

Structure of the merozoite surface protein 1 from Plasmodium falciparum.
Dijkman, P.M. and Marzluf, T. and Zhang, Y. and Chang, S.Y.S. and Helm, D. and Lanzer, M. and Bujard, H. and Kudryashev, M.
Science Advances 7 (23): eabg0465. June 2021

COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab.
Dimai, S. and Semmler, L. and Prabhu, A. and Stachelscheid, H. and Huettemeister, J. and Klaucke, S.C. and Lacour, P. and Blaschke, F. and Kruse, J. and Parwani, A. and Boldt, L.H. and Bullinger, L. and Pieske, B.M. and Heinzel, F.R. and Hohendanner, F.
PLoS ONE 16 (8): e0255976. 19 August 2021

Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M. and Aaby, P.r and Khader, S.A. and Barreiro, L.B. and Bekkering, S. and Chavakis, T. and van Crevel, R. and Curtis, N. and DiNardo, A.R. and Dominguez-Andres, J. and Duivenvoorden, R. and Fanucchi, S. and Fayad, Z. and Fuchs, E. and Hamon, M. and Jeffrey, K.L. and Khan, N. and Joosten, L.A.B. and Kaufmann, E. and Latz, E. and Matarese, G. and van der Meer, J.W.M. and Mhlanga, M. and Moorlag, S.J.C.F.M. and Mulder, W.J.M. and Naik, S. and Novakovic, B. and O'Neill, L. and Ochando, J. and Ozato, K. and Riksen, N.P. and Sauerwein, R. and Sherwood, E.R. and Schlitzer, A. and Schultze, J.L. and Sieweke, M.H. and Benn, C.S. and Stunnenberg, H. and Sun, J. and van de Veerdonk, F.L. and Weis, S. and Williams, D.L. and Xavier, R. and Netea, M.G.
Nature Immunology 22 (1): 2-6. January 2021

Genome sequencing in myeloid cancers.
Dolnik, A. and Schrezenmeier, J. and Bullinger, L.
New England Journal of Medicine 384 (25): e106. 24 June 2021

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M. and Klinger, B. and Mari, T. and Toedling, J. and Blanc, E. and Messerschmidt, C. and Nadler-Holly, M. and Ziehm, M. and Sieber, A. and Hertwig, F. and Beule, D. and Eggert, A. and Schulte, J.H. and Selbach, M. and Blüthgen, N.
PLoS Computational Biology 17 (11): e1009515. 4 November 2021

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M. and Klinger, B. and Mari, T. and Toedling, J. and Blanc, E. and Messerschmidt, C. and Nadler-Holly, M. and Ziehm, M. and Sieber, A. and Hertwig, F. and Beule, D. and Eggert, A. and Schulte, J.H. and Selbach, M. and Blüthgen, N.
bioRxiv : 2021.06.14.448322. 14 June 2021

Modeling Structure-Activity Relationship of AMPK Activation.
Drewe, J. and Küsters, E. and Hammann, F. and Kreuter, M. and Boss, P. and Schöning, V.
Molecules 26 (21): 6508. 1 November 2021

Generation of Epstein-Barr virus antigen-specific T cell receptors recognizing immunodominant epitopes of LMP1, LMP2A, and EBNA3C for immunotherapy.
Dudaniec, K. and Westendorf, K. and Nössner, E. and Uckert, W.
Human Gene Therapy 32 (17-18): 919-935. 21 September 2021

Evaluation of aggression and fearfulness in domestic dog (Canis familiaris).
Dyjak, M. and Boruta, A. and Adamkiewicz, E. and Walasek, A. and Bury-Burzymski, P. and Lisowski, P.
Animal Science Papers and Reports 39 (4): 407-418. 2021

Mechanical forces switch blood vessel subtypes to arrest adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T. and Löhning, M.
Research Square : rs.3.rs-120475. 12 January 2021

The EHA Research Roadmap: Malignant Myeloid Diseases.
Döhner, H. and Malcovati, L. and Ossenkoppele, G.J. and Hochhaus, A. and Maria Vannucchi, A. and Bullinger, L. and Cervantes, F. and Craddock, C. and de Witte, T. and Döhner, K. and Dombret, H. and Fenaux, P. and Geissler, J. and Germing, U. and Guilhot, F. and Harrison, C. and Hellström-Lindberg, E. and Passamonti, F. and Sierra, J. and Skoda, R. and Wierzbowska, A.
HemaSphere 5 (9): e635. September 2021

Germline mutations including the rare pathogenic variant c.3206delC in the ATM gene cause ataxia teleangiectasia-associated primary central nervous system lymphoma.
Dörr, J.R. and Thorwarth, A. and Mizia-Malarz, A. and Radke, J. and Tietze, A. and Hernáiz-Driever, P. and Horn, D. and Gratopp, A. and Eggert, A. and Deubzer, H.E.
Children 8 (6): 469. June 2021

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Ebert, P. and Audano, P. A. and Zhu, Q. and Rodriguez-Martin, B. and Porubsky, D. and Bonder, M.J. and Sulovari, A. and Ebler, J. and Zhou, W. and Serra Mari, R. and Yilmaz, F. and Zhao, X. and Hsieh, P.H. and Lee, J. and Kumar, S. and Lin, J. and Rausch, T. and Chen, Y. and Ren, J. and Santamarina, M. and Höps, W. and Ashraf, H. and Chuang, N.T. and Yang, X. and Munson, K.M. and Lewis, A.P. and Fairley, S. and Tallon, L.J. and Clarke, W.E. and Basile, A.O. and Byrska-Bishop, M. and Corvelo, A. and Evani, U.S. and Lu, T.Y. and Chaisson, M.J.P. and Chen, J. and Li, C. and Brand, H. and Wenger, A.M. and Ghareghani, M. and Harvey, W.T. and Raeder, B. and Hasenfeld, P. and Regier, A.A. and Abel, H.J. and Hall, I.M. and Flicek, P. and Stegle, O. and Gerstein, M.B and Tubio, J.M.C. and Mu, Z. and Li, Y.I. and Shi, X. and Hastie, A.R. and Ye, K. and Chong, Z. and Sanders, A.D. and Zody, M.C. and Talkowski, M.E. and Mills, R. E. and Devine, S.E. and Lee, C. and Korbel, J.O. and Marschall, T. and Eichler, E.E.
Science : eabf7117. 25 February 2021

ASHLEYS: automated quality control for single-cell Strand-seq data.
Eimer, C. and Sanders, A.D. and Korbel, J.O. and Marschall, T. and Ebert, P.
Bioinformatics : btab221. 1 April 2021 (In Press)

Thymoquinone: a tie-breaker in SARS-CoV2-infected cancer patients?
Elgohary, S. and Elkhodiry, A.A. and Amin, N.S. and Stein, U. and El Tayebi, H.M.
Cells 10 (2): 302. 2 February 2021

Base editing repairs an SGCA mutation in human primary muscle stem cells.
Escobar, H. and Krause, A. and Keiper, S. and Kieshauer, J. and Müthel, S. and García de Paredes, M. and Metzler, E. and Kühn, R. and Heyd, F. and Spuler, S.
JCI Insight 6 (10): e145994. 24 May 2021

Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Fiskin, E. and Lareau, C.A. and Ludwig, L.S. and Eraslan, G. and Liu, F. and Ring, A.M. and Xavier, R.J. and Regev, A.
Nature Biotechnology 40 (3): 374-381. March 2021

An autochthonous mouse model of Myd88- and BCL2-driven diffuse large B-cell lymphoma reveals actionable molecular vulnerabilities.
Flümann, R. and Rehkämper, T. and Nieper, P. and Pfeiffer, P. and Holzem, A. and Klein, S. and Bhatia, S. and Kochanek, M. and Kisis, I. and Pelzer, B.W. and Ahlert, H. and Hauer, J. and da Palma Guerreiro, A. and Ryan, J.A. and Reimann, M. and Riabinska, A. and Wiederstein, J. and Krüger, M. and Deckert, M. and Altmüller, J. and Klatt, A.R. and Frenzel, L.P. and Pasqualucci, L. and Béguelin, W. and Melnick, A.M. and Sander, S. and Montesinos-Rongen, M. and Brunn, A. and Lohneis, P. and Büttner, R. and Kashkar, H. and Borkhardt, A. and Letai, A. and Persigehl, T. and Peifer, M. and Schmitt, C.A. and Reinhardt, H.C. and Knittel, G.
Blood Cancer Discovery 2 (1): 70-91. January 2021

Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics.
Franz, A. and Coscia, F. and Shen, C. and Charaoui, L. and Mann, M. and Sander, C.
Journal of Ovarian Research 14 (1): 140. 22 October 2021

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells.
Fu, R. and Wellman, K. and Baldwin, A. and Rege, J. and Walters, K. and Hirsekorn, A. and Riemondy, K. and Rainey, W.E and Mukherjee, N.
RNA 27 (8): 933-945. August 2021

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects.
Galgoczi, S. and Ruzo, A. and Markopoulos, C. and Yoney, A. and Phan-Everson, T. and Li, S. and Haremaki, T. and Metzger, J.J. and Etoc, F. and Brivanlou, A.H.
Development 148 (19): dev199513. October 2021

Landscape of HER2-low metastatic breast cancer (MBC): results from the Austrian AGMT_MBC-Registry.
Gampenrieder, S.P. and Rinnerthaler, G. and Tinchon, C. and Petzer, A. and Balic, M. and Heibl, S. and Schmitt, C. and Zabernigg, A.F. and Egle, D. and Sandholzer, M. and Singer, C.F. and Roitner, F. and Hager, C. and Andel, J. and Hubalek, M. and Knauer, M. and Greil, R.
Breast Cancer Research 23 (1): 112. 14 December 2021

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M. and Vancraenenbroeck, R. and Rosenblum, G. and Hofmann, H. and Mikhailov, A.S. and Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2101144118. 13 July 2021

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A. and Roske, Y. and Yamada, S. and Uehata, T. and Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49 (9): 5369-5381. 21 May 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C. and Papies, J. and Bajaj, T. and Emanuel, J. and Dethloff, F. and Chua, R.L. and Trimpert, J. and Heinemann, N. and Niemeyer, C. and Weege, F. and Hönzke, K. and Aschman, T. and Heinz, D.E. and Weckmann, K. and Ebert, T. and Zellner, A. and Lennarz, M. and Wyler, E. and Schroeder, S. and Richter, A. and Niemeyer, D. and Hoffmann, K. and Meyer, T.F. and Heppner, F.L. and Corman, V.M. and Landthaler, M. and Hocke, A.C. and Morkel, M. and Osterrieder, N. and Conrad, C. and Eils, R. and Radbruch, H. and Giavalisco, P. and Drosten, C. and Müller, M.A.
Nature Communications 12 (1): 3818. 21 June 2021

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Stein, J. and Dey, H.P. and Paclik, D. and Mülleder, M. and Aulakh, S.K. and Mei, H.E. and Schulz, A.R. and Hippenstiel, S. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer-Wasserscheid, B. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
medRxiv : 2021.06.08.21258481. 11 June 2021

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.
Giacopelli, B. and Wang, M. and Cleary, A. and Wu, Y.Z. and Schultz, A.R. and Schmutz, M. and Blachly, J.S. and Eisfeld, A.K. and Mundy-Bosse, B. and Vosberg, S. and Greif, P.A. and Claus, R. and Bullinger, L. and Garzon, R. and Coombes, K.R. and Bloomfield, C.D. and Druker, B.J. and Tyner, J.W. and Byrd, J.C. and Oakes, C.C.
Genome Research 31 (5): 747-761. May 2021

Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
Gillissen, B. and Richter, A. and Essmann, F. and Kemmner, W.
BMC Cancer 21 (1): 971. 30 August 2021

Editorial: Monocyte heterogeneity and function.
Ginhoux, F. and Mildner, A. and Gautier, E.L. and Schlitzer, A. and Jakubzick, C. and Varol, C. and Bain, C. and Guermonprez, P.
Frontiers in Immunology 11 : 626725. 7 January 2021

Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O. and Zincke, F. and Eckert, A. and Kobelt, D. and Preissner, S. and Liebeskind, J.M. and Gunkel, N. and Putzker, K. and Lewis, J. and Preissner, S. and Kortüm, B. and Walther, W. and Mura, C. and Bourne, P.E. and Stein, U. and Preissner, R.
medRxiv : 2021.07.20.21260891. 22 July 2021

The zinc finger antiviral protein ZAP restricts human cytomegalovirus and selectively binds and destabilizes viral UL4/UL5 transcripts.
Gonzalez-Perez, A.C. and Stempel, M. and Wyler, E. and Urban, C. and Piras, A. and Hennig, T. and Ganskih, S. and Wei, Y. and Heim, A. and Landthaler, M. and Pichlmair, A. and Dölken, L. and Munschauer, M. and Erhard, F. and Brinkmann, M.M.
mBio 12 (3): e02683-20. 4 May 2021

MLL1 is required for maintenance of intestinal stem cells.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
PLoS Genetics 17 (12): e1009250. 3 December 2021

Survivin’ acute myeloid leukaemia - a personalised target for inv(16) patients.
Greiner, J. and Brown, E. and Bullinger, L. and Hills, R.K. and Morris, V. and Döhner, H. and Mills, K.I. and Guinn, B.A.
International Journal of Molecular Sciences 22 (19): 10482. 1 October 2021

A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization.
Grunewald, L. and Lam, T. and Andersch, L. and Klaus, A. and Schwiebert, S. and Winkler, A. and Gauert, A. and Heeren-Hagemann, A.I. and Astrahantseff, K. and Klironomos, F. and Thomas, A. and Deubzer, H.E. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Anders, K. and Kloke, L. and Künkele, A.
Frontiers in Immunology 12 : 689697. 29 June 2021

How to find genomic regions relevant for gene regulation.
Guo, X. and Ohler, U. and Yildirim, F.
Medizinische Genetik 33 (2): 157-165. 14 August 2021

A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3.
Halatsch, M.E. and Kast, R.E. and Karpel-Massler, G. and Mayer, B. and Zolk, O. and Schmitz, B. and Scheuerle, A. and Maier, L. and Bullinger, L. and Mayer-Steinacker, R. and Schmidt, C. and Zeiler, K. and Elshaer, Z. and Panther, P. and Schmelzle, B. and Hallmen, A. and Dwucet, A. and Siegelin, M.D. and Westhoff, M.A. and Beckers, K. and Bouche, G. and Heiland, T.
Neuro-Oncology Advances 3 (1): vdab075. 7 August 2021

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P. and Mustroph, J. and Stauber, T. and Birchmeier, W. and Wagner, S. and Maier, L.S.
PLoS ONE 16 (6): e0252649. 4 June 2021

Timed global reorganization of protein synthesis during neocortex neurogenesis at codon resolution.
Harnett, D. and Ambrozkiewicz, M.C. and Zinnall, U. and Borisova, E. and Rusanova, A. and Dannenberg, R. and Imami, K. and Münster-Wandowski, A. and Fauler, B. and Mielke, T. and Selbach, M. and Landthaler, M. and Spahn, C.M.T. and Tarabykin, V. and Ohler, U. and Kraushar, M.L.
bioRxiv : 2021.06.23.449626. 24 June 2021

Genome-wide analysis of actively translated open reading frames using riboTaper/ORFquant.
Harnett, D. and Meerdink, E. and Calviello, L. and Sydow, D. and Ohler, U.
Methods in Molecular Biology 2252 : 331-346. 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A. and Sieverling, L. and Nadler-Holly, M. and Ziehm, M. and Toprak, U.H. and Herrmann, C. and Ishaque, N. and Okonechnikov, K. and Gartlgruber, M. and Park, Y.G. and Wecht, E.M. and Savelyeva, L. and Henrich, K.O. and Rosswog, C. and Fischer, M. and Hero, B. and Jones, D.T.W. and Pfaff, E. and Witt, O. and Pfister, S.M. and Volckmann, Ri. and Koster, J. and Kiesel, K. and Rippe, K. and Taschner-Mandl, S. and Ambros, P. and Brors, B. and Selbach, M. and Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Insulin-like growth factor binding protein-2 (IGFBP2) is a key molecule in the MACC1-mediated platelet communication and metastasis of colorectal cancer cells.
Haschemi, R. and Kobelt, D. and Steinwarz, E. and Schlesinger, M. and Stein, U. and Bendas, G.
International Journal of Molecular Sciences 22 (22): 12195. 11 November 2021

CD4+ T cell dependent B cell recovery and function after autologous hematopoietic stem cell transplantation.
Heck, C. and Steiner, S. and Kaebisch, E.M. and Frentsch, M. and Wittenbecher, F. and Scheibenbogen, C. and Hanitsch, L.G. and Nogai, A. and le Coutre, P. and Bullinger, L. and Blau, I.W. and Na, I.K.
Frontiers in Immunology 12 : 736137. September 2021

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M. and Eichner, R. and Stroh, J. and Morath, V. and Kuisl, A. and Zecha, J. and Lawatscheck, J. and Baek, K. and Garz, A.K. and Rudelius, M. and Deuschle, F.C. and Keller, U. and Lemeer, S. and Verbeek, M. and Götze, K.S. and Skerra, A. and Weber, W.A. and Buchner, J. and Schulman, B.A. and Kuster, B. and Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81 (6): 1170-1186. 18 March 2021

Cold-shock domains - abundance, structure, properties, and nucleic-acid binding.
Heinemann, U. and Roske, Y.
Cancers 13 (2): 190. 7 January 2021

A comparison of nine machine learning mutagenicity models and their application for predicting pyrrolizidine alkaloids.
Helma, C. and Schöning, V. and Drewe, J. and Boss, P.
Frontiers in Pharmacology 12 : 708050. 22 July 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S. and Heimann, A. and Obermayer, B. and Ciraolo, E. and Althoff, S. and Ruß, J. and Grunert, C. and Busse, A. and Bullinger, L. and Pezzutto, A. and Blankenstein, T. and Beule, D. and Na, I.K.
International Journal of Cancer 148 (12): 3097-3110. 15 June 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations.
Heuser, M. and Heida, B. and Büttner, K. and Wienecke, C.P. and Teich, K. and Funke, C. and Brandes, M. and Klement, P. and Liebich, A. and Wichmann, M. and Neziri, B. and Chaturvedi, A. and Kloos, A. and Mintzas, K. and Gaidzik, V.I. and Paschka, P. and Bullinger, L. and Fiedler, W. and Heim, A. and Puppe, W. and Krauter, J. and Döhner, K. and Döhner, H. and Ganser, A. and Stadler, M. and Hambach, L. and Gabdoulline, R. and Thol, F.
Blood Advances 5 (9): 2294-2304. 11 May 2021

Construction of whole genomes from scaffolds using single cell strand-seq data.
Hills, M. and Falconer, E. and O'Neill, K. and Sanders, A.D. and Howe, K. and Guryev, V. and Lansdorp, P.M.
International Journal of Molecular Sciences 22 (7): 3617. 1 April 2021

A public health antibody screening indicates a 6-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M. and Holthaus, L. and Assfalg, R. and Zapardiel Gonzalo, J.M. and Kapfelsperger, H. and Heigermoser, M. and Haupt, F. and Ewald, D.A. and Welzhofer, T.C. and Marcus, B.A. and Heck, S. and Koelln, A. and Stock, J. and Voss, F. and Secchi, M. and Piemonti, L. and de la Rosa, K. and Protzer, U. and Boehmer, M. and Achenbach, P. and Lampasona, V. and Bonifacio, E. and Ziegler, A.G.
Med 2 (2): 149-163. 12 February 2021

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
Ho, J.S. and Di Tullio, F. and Schwarz, M. and Low, D. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J.X. and Wollmann, H. and Chen, L. and An, O. and Chan, T.H.M. and Hall Hickman, A. and Zheng, S. and Roudko, V. and Chen, S. and Karz, A. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Oliviero, S. and Serresi, M. and Gargiulo, G. and Mann, K.M. and Hernando, E. and Mulholland, D. and Marazzi, I. and Wee, D.K.B. and Guccione, E.
eLife 10 : e59654. 2 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K. and Hablesreiter, R. and Inoue, Y. and Yoshida, K. and Briest, F. and Christen, F. and Kakiuchi, N. and Yoshizato, T. and Shiozawa, Y. and Shiraishi, Y. and Striefler, J.K. and Bischoff, S. and Lohneis, P. and Putter, H. and Blau, O. and Keilholz, U. and Bullinger, L. and Pelzer, U. and Hummel, M. and Riess, H. and Ogawa, S. and Sinn, M. and Damm, F.
EBioMedicine 66 : 103327. April 2021

Mit Einzelzell-Genomik die Entscheidungen von Zellen verfolgen [Deciphering cell fate decisions using single cell genomics].
Hu, B. and Junker, J.P.
BIOspektrum 27 (1): 25-27. February 2021

Cellular drivers of injury response and regeneration in the adult zebrafish heart.
Hu, B. and Lelek, S. and Spanjaard, B. and Simões, M.G. and Aliee, H. and Schäfer, R. and Theis, F. and Panáková, D. and Junker, J.P.
bioRxiv : 2021.01.07.425670. 7 January 2021

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L. and Yost, K.E. and Xie, L. and Shi, Q. and Helmsauer, K. and Luebeck, J. and Schöpflin, R. and Lange, J.T. and Chamorro González, R. and Weiser, N.E. and Chen, C. and Valieva, M.E. and Wong, I.T.L. and Wu, S. and Dehkordi, S.R. and Duffy, C.V. and Kraft, K. and Tang, J. and Belk, J.A. and Rose, J.C. and Corces, M.R. and Granja, J.M. and Li, R. and Rajkumar, U. and Friedlein, J. and Bagchi, A. and Satpathy, A.T. and Tjian, R. and Mundlos, S. and Bafna, V. and Henssen, A.G. and Mischel, P.S. and Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. and Sigal, M.
International Journal of Medical Microbiology 311 (3): 151486. April 2021

Clinical outcome of older adults with acute myeloid leukemia: an analysis of a large tertiary referral center over two decades.
Ihlow, J. and Gross, S. and Neuendorff, N.R. and Busack, L. and Herneth, A. and Singh, A. and Schwarz, M. and Flörcken, A. and Anagnostopoulos, I. and Türkmen, S. and Burmeister, T. and Blau, I.W. and Bullinger, L. and Westermann, J.
Journal of Geriatric Oncology 12 (4): 540-549. May 2021

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J. and Michaelis, E. and Greuel, S. and Heynol, V. and Lehmann, A. and Radbruch, H. and Meinhardt, J. and Miller, F. and Herbst, H. and Corman, V.M. and Westermann, J. and Bullinger, L. and Horst, D. and von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103 : 628-635. February 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F. and Dahlmann, M. and Sporbert, A. and Ciolli Mattioli, C. and Mari, T. and Scholz, F. and Timm, L. and Twamley, S. and Migotti, R. and Walther, W. and Dittmar, G. and Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold.
Irmscher, T. and Roske, Y. and Gayk, I. and Dunsing, V. and Chiantia, S. and Heinemann, U. and Barbirz, S.
Journal of Biological Chemistry 296 : 100286. 2021

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N. and Roske, Y. and Kovalskyy, D. and Platonov, M.O. and Balinskyi, O. and Kreuchwig, A. and Saupe, J. and Fang, L. and Diehl, A. and Schmieder, P. and Krause, G. and Rademann, J. and Heinemann, U. and Birchmeier, W. and Oschkinat, H.
Magnetic Resonance 2 (1): 355-374. 2 June 2021

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells.
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Lancet Haematology 8 (6): e398-e409. June 2021

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
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Nature Communications 12 (1): 6761. 19 November 2021

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Health workforce response to Covid-19: What pandemic preparedness planning and action at the federal and state levels in Germany? Germany's health workforce responses to Covid-19.
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Survey of long-term experiences of sperm cryopreservation in oncological and non-oncological patients: usage and reproductive outcomes of a large monocentric cohort.
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Experimental Cell Research 409 (2): 112933. 15 December 2021

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Nature Biotechnology 39 (4): 451-461. April 2021

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Nature 599 : 283-289. 11 November 2021

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Cell 184 (14): 3660-3673. 8 July 2021

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bioRxiv : 2021.03.20.436222. 20 March 2021

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Blood Advances 5 (5): 1490-1503. 9 March 2021

Analysis of correlation and ionization from pair distributions in many-electron systems.
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European Physical Journal Plus 136 (7): 763. 22 July 2021

Humoral and cellular immune responses in SARS-CoV-2 mRNA-vaccinated patients with cancer.
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Cancer Cell 39 (9): 1171-1172. 13 September 2021

Disrupting the CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
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bioRxiv : 2021.05.17.444335. 17 May 2021

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Nature Communications 12 (1): 5330. 9 September 2021

GAMIBHEAR: whole-genome haplotype reconstruction from Genome Architecture Mapping data.
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Bioinformatics 37 (19): 3128–3135. 1 October 2021

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1.
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eLife 10 : e64846. 17 August 2021

CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo.
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Nucleic Acids Research 49 (4): e19. 26 February 2021

The relevance of the SH2 domain for c-Src functionality in triple-negative breast cancer cells.
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Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data.
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BMC Genomics 22 (1): 84. 28 January 2021

Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populations.
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Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
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Nature Biotechnology 39 (10): 1246-1258. October 2021

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Briefings in Functional Genomics 20 (6): 420–426. November 2021

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Nature Cell Biology 23 (10): 1073-1084. October 2021

Assessment of coronary artery disease during hospitalization for cancer treatment.
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A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq.
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bioRxiv : 2021.06.10.447896. 10 June 2021

AI-driven Deep Visual Proteomics defines cell identity and heterogeneity.
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bioRxiv : 2021.01.25.427969. 27 January 2021

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C. and Luecken, M.D. and Eraslan, G. and Sikkema, L. and Waghray, A. and Heimberg, G. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smillie, C. and Jagadeesh, K.A. and Duong, E.T. and Fiskin, E. and Triglia, E.T. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Callori, S. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Cuomo, A.S.E. and Deprez, M. and Duclos, G. and Fine, D. and Fischer, D.S. and Ghazanfar, S. and Gillich, A. and Giotti, B. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Hu, Y. and Jaiswal, A. and Ji, L. and Jiang, P. and Kapellos, T.S. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Ludwig, L.S. and Lukassen, S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Leroy, S. and Mayr, C.H. and Mbano, I.M. and McAdams, A.M. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J.C. and Shea, C.V. and Shi, X. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N.P. and Sountoulidis, A. and Strunz, M. and Sullivan, T.B. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K.A. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Xu, K. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27 (3): 546-559. 2 March 2021

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R. and Hilal, T. and Schmidt, S. and Qin, B. and Schwefel, D. and Vieira-Vieira, C.H. and Mielke, T. and Bürger, J. and Loerke, J. and Amikura, K. and Flügel, T. and Ueda, T. and Selbach, M. and Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81 (6): 1200-1215. 18 March 2021

Genomic landscape and clonal evolution of AML.
Noerenberg, D. and Damm, F. and Bullinger, L.
In: Acute Myeloid Leukemia. Hematologic Malignancies . Springer, Cham, 103-118. ISBN 978-3-030-72675-1 2021

Maternal angiotensin increases placental leptin in early gestation via an alternative renin-angiotensin system pathway: suggesting a link to preeclampsia.
Nonn, O. and Fischer, C. and Geisberger, S. and El-Heliebi, A. and Kroneis, T. and Forstner, D. and Desoye, G. and Staff, A.C. and Sugulle, M. and Dechend, R. and Pecks, U. and Kollmann, M. and Stern, C. and Cartwright, J.E. and Whitley, G.S. and Thilaganathan, B. and Wadsack, C. and Huppertz, B. and Herse, F. and Gauster, M.
Hypertension 77 (5): 1723-1736. May 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Muelleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

Longitudinal omics in Syrian hamsters integrated with human data unravel cellular effector responses to moderate COVID-19.
Nouailles, Geraldine and Wyler, E. and Pennitz, P. and Postmus, D. and Vladrimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M.l and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Research Square : rs-148392/v1. 28 January 2021

High-dose glucocorticoid treatment of near-fatal Bocavirus lung infection results in rapid recovery.
Obenaus, M. and Schildgen, O. and Schürmann, D. and von Brünneck, A.C. and Janz, M. and Keller, U. and Gebauer, B. and Schilling, J. and Schwartz, S. and Weissbrich, B. and Schneider, T. and Hofmann, J. and Mathas, S.
ERJ Open Research 7 (2): 00060-2021. 12 April 2021

Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K. and Teranishi, K. and Ambroso, M.R. and Isas, J.M. and Vazquez-Sarandeses, E. and Lee, J.Y. and Melo, A.A. and Pandey, P. and Merken, D. and Berndt, L. and Lammers, M. and Daumke, O. and Chang, K. and Haworth, I.S. and Langen, R.
Nature Communications 12 (1): 6466. 9 November 2021

58/w mit zunehmender psychomotorischer Verlangsamung und Zephalgien [58/f with increasing psychomotor retardation and headache].
Onken, J.S. and Bullinger, L.
Onkologe 27 : 79-84. September 2021

Effective oncoleaking treatment of pancreatic cancer by claudin-targeted suicide gene therapy with Clostridium perfringens enterotoxin (CPE).
Pahle, J. and Kobelt, D. and Aumann, J. and Behrens, D. and Daberkow, O. and Mokritzkij, M. and Piontek, J. and Stein, U. and Walther, W.
Cancers 13 (17): 4393. 1 September 2021

Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L. and Gohil, S.H. and Lareau, C. and Ludwig, L.S. and Parry, E.M. and Huang, T. and Li, S. and Zhang, W. and Livitz, D. and Leshchiner, I. and Parida, L. and Getz, G. and Rassenti, L.Z. and Kipps, T.J. and Brown, J.R. and Davids, M.S. and Neuberg, D.S. and Livak, K.J. and Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11 (12): 3048-3063. December 2021

Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.
Phan, Q.V. and Bogdanow, B. and Wyler, E. and Landthaler, M. and Liu, F. and Hagemeier, C. and Wiebusch, L.
bioRxiv : 2021.07.20.453063. 20 July 2021

Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes.
Pishesha, N. and Harmand, T. and Smeding, L.Y. and Ma, W. and Ludwig, L.S. and Janssen, R. and Islam, A. and Xie, Y.J. and Fang, T. and McCaul, N. and Pinney, W. and Sugito, H.R. and Rossotti, M.A. and Gonzalez-Sapienza, G. and Ploegh, H.L.
Nature Biomedical Engineering 5 (11): 1389-1401. November 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L. and Jarosch, E. and Zauber, H. and Kniss, A. and Waltho, A. and Bagola, K. and von Delbrück, M. and Löhr, F. and Schulman, B.A. and Selbach, M. and Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F. and Corbo, J. and Levdansky, Y. and Spiegelhalter, A. and Lindner, D. and Magg, V. and Lebedeva, S. and Schweiggert, J. and Schott, J. and Valkov, E. and Stoecklin, G.
Nature Communications 12 (1): 7175. 9 December 2021

ECG scoring for the evaluation of therapy-naïve cancer patients to predict cardiotoxicity.
Pohl, J. and Mincu, R.I. and Mrotzek, S.M. and Wakili, R. and Mahabadi, A.A. and Potthoff, S.K. and Siveke, J.T. and Keller, U. and Landmesser, U. and Rassaf, T. and Anker, M.S. and Totzeck, M.
Cancers 13 (6): 1197. 10 March 2021

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads.
Porubsky, D. and Ebert, P. and Audano, P.A. and Vollger, M.R. and Harvey, W.T. and Marijon, P. and Ebler, J. and Munson, K.M. and Sorensen, M. and Sulovari, A. and Haukness, M. and Ghareghani, M. and Lansdorp, P.M. and Paten, B. and Devine, S.E. and Sanders, A.D. and Lee, C. and Chaisson, M.J.P. and Korbel, J.O. and Eichler, E.E. and Marschall, T.
Nature Biotechnology 39 (3): 302-308. March 2021

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10 (1): 2151-2168. 16 November 2021

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.06.07.138610. 11 June 2021

Therapy-induced senescence: opportunities to improve anticancer therapy.
Prasanna, P.G. and Citrin, D.E. and Hildesheim, J. and Ahmed, M.M. and Venkatachalam, S. and Riscuta, G. and Xi, D. and Zheng, G. and van Deursen, J. and Goronzy, J. and Kron, S.J. and Anscher, M.S. and Sharpless, N.E. and Campisi, J. and Brown, S.L. and Niedernhofer, L.J. and O'Loghlen, A. and Georgakilas, A.G. and Paris, F. and Gius, D. and Gewirtz, D.A. and Schmitt, C.A. and Abazeed, M.E. and Kirkland, J.L. and Richmond, A. and Romesser, P.B. and Lowe, S.W. and Gil, J. and Mendonca, M.S. and Burma, S. and Zhou, D. and Coleman, C.N.
Journal of the National Cancer Institute 113 (10): 1285-1298. October 2021

cDNA-detector: detection and removal of cDNA contamination in DNA sequencing libraries.
Qi, M. and Nayar, U. and Ludwig, L.S. and Wagle, N. and Rheinbay, E.
BMC Bioinformatics 22 (1): 611. 24 December 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 81 (8): 2116-2127. April 2021

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.
Rajasekaran, S. and Siddiqui, J. and Rakijas, J. and Nicolay, B. and Lin, C. and Khan, E. and Patel, R. and Morris, R. and Wyler, E. and Boukhali, M. and Balasubramanyam, J. and Ranjith Kumar, R. and Van Rechem, C. and Vogel, C. and Elchuri, S.V. and Landthaler, M. and Obermayer, B. and Haas, W. and Dyson, N. and Miles, W.
Communications Biology 4 (1): 977. 17 August 2021

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
iScience 24 (6): 102686. 25 June 2021

A universal peptide matrix interactomics approach to disclose motif dependent protein binding.
Ramberger, E. and Suarez-Artiles, L. and Perez-Hernandez, D. and Haji, M. and Popp, O. and Reimer, U. and Leutz, A. and Dittmar, G. and Mertins, P.
Molecular & Cellular Proteomics 20 : 100135. 13 August 2021

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.
Rapaport, F. and Neelamraju, Y. and Baslan, T. and Hassane, D. and Gruszczynska, A. and de Massy, M.R. and Farnoud, N. and Haddox, S. and Lee, T. and Medina-Martinez, J. and Sheridan, C. and Thurmond, A. and Becker, M. and Bekiranov, S. and Carroll, M. and Moses Murdock, H. and Valk, P.J.M. and Bullinger, L. and D’Andrea, R. and Lowe, S.W. and Neuberg, D. and Levine, R.L. and Melnick, A. and Garrett-Bakelman, F.E.
Leukemia 35 (9): 2688-2692. September 2021

PiggyBac transposable element-derived 1 controls neuronal progenitor identity, stress sensing and mammal-specific paraspeckles.
Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T. and Prigione, A. and Hurst, L.D. and Izsvák, Z.
bioRxiv : 2021.05.19.444448. 19 May 2021

Expanding the phenotype of NUP85 mutations beyond nephrotic syndrome to primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders.
Ravindran, E. and Jühlen, R. and Vieira-Vieira, C.H. and Ha, T. and Salzberg, Y. and Fichtman, B. and Luise-Becker, L. and Martins, N. and Picker-Minh, S. and Bessa, P. and Arts, P. and Jackson, M.R. and Taranath, A. and Kamien, B. and Barnett, C. and Li, N. and Tarabykin, V. and Stoltenburg-Didinger, G. and Harel, A. and Selbach, M. and Dickmanns, A. and Fahrenkrog, B. and Hu, H. and Scott, H. and Kaindl, A.M.
Human Molecular Genetics 30 (22): 2068-2081. 15 November 2021

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Regina, C. and Hamed, E. and Andrieux, G. and Angenendt, S. and Schneider, M. and Ku, M. and Follo, M. and Wachtel, M. and Ke, E. and Kikuchi, K. and Henssen, A.G. and Schäfer, B.W. and Boerries, M. and Wagers, A.J. and Keller, C. and Hettmer, S.
Life Science Alliance 4 (9): e202001002. September 2021

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M. and Schrezenmeier, J.F. and Richter-Pechanska, P. and Dolnik, A. and Hick, T.P. and Schleich, K. and Cai, X. and Fan, D.N.Y. and Lohneis, P. and Masswig, S. and Denker, S. and Busse, A. and Knittel, G. and Flümann, R. and Childs, D. and Childs, L. and Gätjens-Sanchez, A.M. and Bullinger, L. and Rosenwald, A. and Reinhardt, H.C. and Schmitt, C.A.
Blood 137 (20): 2785-2899. 20 May 2021

Investigating the concept of accessibility for predicting novel RNA-RNA interactions.
Reißer, S. and Meyer, I.M.
bioRxiv : 2021.06.03.446902. 3 June 2021

Capecitabine in combination with bendamustine in pretreated women with HER2-negative metastatic breast cancer: results of a phase II trial (AGMT MBC-6).
Rinnerthaler, G. and Gampenrieder, S.P. and Petzer, A. and Hubalek, M. and Petru, E. and Sandholzer, M. and Andel, J. and Balic, M. and Melchardt, T. and Hauser-Kronberger, C. and Schmitt, C.A. and Ulmer, H. and Greil, R.
Therapeutic Advances in Medical Oncology 13 : 17588359211042301. 19 October 2021

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.
Rivera, M. and Fichtner, I. and Wulf-Goldenberg, A. and Sers, C. and Merk, J. and Patone, G. and Alp, K.M. and Kanashova, T. and Mertins, P. and Hoffmann, J. and Stein, U. and Walther, W.
Neoplasia 23 (1): 21-35. January 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I. and Poon, E. and Henssen, A.G. and Dorado Garcia, H. and Gatti, M. and Giansanti, C. and Jamin, Y. and Ade, C.P. and Gallant, P. and Schülein-Völk, C. and Beli, P. and Richards, M. and Rosenfeldt, M. and Altmeyer, M. and Anderson, J. and Eggert, A. and Dobbelstein, M. and Bayliss, R. and Chesler, L. and Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1.
Rybak-Wolf, A. and Wyler, E. and Legnini, I. and Loewa, A. and Glažar, P. and Kim, S.J. and Pentimalli, T.M. and Oliveras Martinez, A. and Beyersdorf, B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
bioRxiv : 2021.03.05.434122. 7 March 2021

Charting a DNA repair roadmap for immunoglobulin class switch recombination.
Saha, T. and Sundaravinayagam, D. and Di Virgilio, M.
Trends in Biochemical Sciences 46 (3): 184-199. March 2021

The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents.
Scheer, M. and Vokuhl, C. and Bauer, S. and Fuchs, J. and Loff, S. and Timmermann, B. and Münter, M. and Henssen, A.G. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 147 (12): 3735-3747. December 2021

Netboost: boosting-supported network analysis improves high-dimensional omics prediction in acute myeloid leukemia and Huntington's disease.
Schlosser, P. and Knaus, J. and Schmutz, M. and Döhner, K. and Plass, C. and Bullinger, L. and Claus, R. and Binder, H. and Lübbert, M. and Schumacher, M.
IEEE/ACM Transactions on Computational Biology and Bioinformatics 18 (6): 2635-2648. 1 November 2021

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
Schmalbrock, L.K. and Dolnik, A. and Cocciardi, S. and Sträng, E. and Theis, F. and Jahn, N. and Panina, E. and Blätte, T.J. and Herzig, J.K. and Skambraks, S. and Rücker, F.G. and Gaidzik, V.I. and Paschka, P. and Fiedler, W. and Salih, H.R. and Wulf, G.G. and Schroeder, T. and Lübbert, M. and Schlenk, R.F. and Thol, F. and Heuser, M. and Larson, R.A. and Ganser, A. and Stunnenberg, H.G. and Minucci, S. and Stone, R.M. and Bloomfield, C.D. and Döhner, H. and Döhner, K. and Bullinger, L.
Blood 137 (22): 3093-3104. 3 June 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K. and Toedling, J. and Huska, M. and Cwikla, M.C. and Kruetzfeldt, L.M. and Proba, J. and Ambros, P.F. and Ambros, I.M. and Boral, S. and Lodrini, M. and Chen, C.Y. and Burkert, M. and Guergen, D. and Szymansky, A. and Astrahantseff, K. and Kuenkele, A. and Haase, K. and Fischer, M. and Deubzer, H.E. and Hertwig, F. and Hundsdoerfer, P. and Henssen, A.G. and Schwarz, R.F. and Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O. and Nehls, N. and Prexler, C. and von Heyking, K. and Groll, T. and Pardon, K. and Garcia, H.D. and Hensel, T. and Gürgen, D. and Henssen, A.G. and Eggert, A. and Steiger, K. and Burdach, S. and Richter, G.H.S.
Journal of Experimental & Clinical Cancer Research 40 (1): 322. 15 October 2021

TFE3 activation in a TSC1-altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms.
Schmiester, M. and Dolnik, A. and Kornak, U. and Pfitzner, B. and Hummel, M. and Treue, D. and Hartmann, A. and Agaimy, A. and Weyerer, V. and Lekaj, A. and Brakemeier, S. and Peters, R. and Öllinger, R. and Märdian, S. and Bullinger, L. and Striefler, J.K. and Flörcken, A.
Journal of Pathology Clinical Research 7 (1): 3-9. January 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. and Company, C. and Dramaretska, Y. and Barozzi, I. and Göhrig, A. and Kertalli, S. and Großmann, M. and Naumann, H. and Sánchez-Bailón, M.P. and Hulsman, D. and Glass, R. and Squatrito, M. and Serresi, M. and Gargiulo, G.
Cancer Discovery 11 (3): 754-777. March 2021

A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL.
Schmitz, N. and Truemper, L.H. and Bouabdallah, K. and Ziepert, M. and Leclerc, M. and Cartron, G. and Jaccard, A. and Reimer, P. and Wagner-Drouet, E.M. and Wilhelm, M. and Sanhes, L. and Lamy, T. and de Leval, L. and Rosenwald, A. and Roussel, M. and Kroschinsky, F.P. and Lindemann, W.W. and Dreger, P. and Viardot, A. and Milpied, N.J. and Gisselbrecht, C. and Wulf, G.G. and Gyan, E. and Gaulard, P. and Bay, J.O. and Glass, B. and Poeschel, V. and Damaj, G. and Sibon, D. and Delmer, A.J. and Bilger, K. and Banos, A. and Haenel, M. and Dreyling, M. and Metzner, B. and Keller, U. and Braulke, F. and Friedrichs, B. and Nickelsen, M. and Altmann, B. and Tournilhac, O.
Blood 137 (19): 2646-2656. 13 May 2021

The SUMO pathway in pancreatic cancer: insights and inhibition.
Schneeweis, C. and Hassan, Z. and Schick, M. and Keller, U. and Schneider, G.
British Journal of Cancer 124 (3): 531-538. 2 February 2021

Rationale for MYC imaging and targeting in pancreatic cancer.
Schneider, G. and Wirth, M. and Keller, U. and Saur, D.
EJNMMI Research 11 (1): 104. 12 October 2021

NEMHESYS - European perspective on the implementation of next-generation sequencing into clinical diagnostics.
Serramito-Gómez, I. and Clarke, K.M. and Rodríguez-Vicente, A.E. and McGimpsey, J.E. and Abáigar, M. and Díez, C.B. and Benito, R. and Bullinger, L. and Mills, K.I. and Hernández Rivas, J.M.
HemaSphere 5 (3): e541. March 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain.
Sheinman, M. and Arkhipova, K. and Arndt, P.F. and Dutilh, B.E. and Hermsen, R. and Massip, F.
eLife 10 : e62719. 9 July 2021

Wie das Immunsystem SARS-CoV-2 den Weg ebnet [How the immune system paves the way for SARS-CoV-2].
Sigal, M.
Hygiene und Medizin 46 (3): 22-23. 2021

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
Singh, Y. and Trautwein, C. and Fendel, R. and Krickeberg, N. and Berezhnoy, G. and Bissinger, R. and Ossowski, S. and Salker, M.S. and Casadei, N. and Riess, O.
Heliyon 7 (6): e07147. June 2021

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
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KDD Health Day/DSHealth 2021: Joint KDD 2021 Health Day and 2021 KDD Workshop on Applied Data Science for Healthcare: state of XAI and trustworthiness in health.
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Extend, don’t rebuild: Phrasing conditional graph modification as autoregressive sequence labelling.
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HunFlair: an easy-to-use tool for state-of-the-art biomedical named entity recognition.
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Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
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The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
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In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo.
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Nature 597 (7874): 87-91. 2 September 2021

The mTOR inhibitor temsirolimus added to rituximab combined with dexamethasone, cytarabine, and cisplatinum (R-DHAP) for the treatment of patients with relapsed or refractory DLBCL - results from the phase-II STORM trial.
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Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
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Bioprinted cancer model of neuroblastoma in a renal microenvironment as an efficiently applicable drug testing platform.
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Wnt signalling pathway in bladder cancer.
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Identification of unique long non-coding RNAs as putative biomarkers for chromophobe renal cell carcinoma.
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Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
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Leukemia 35 (1): 143-155. January 2021

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Aberrant expression of and cell death induction by engagement of the MHC-II chaperone CD74 in anaplastic large cell lymphoma (ALCL).
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Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology.
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International Journal of Hyperthermia 38 (1): 715-731. 28 April 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
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CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
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ME2 promotes proneural–mesenchymal transition and lipogenesis in glioblastoma.
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Frontiers in Oncology 11 : 715593. 23 July 2021

Depletion of aneuploid cells in human embryos and gastruloids.
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Nature Cell Biology 23 (4): 314-321. April 2021

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
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Cell Stem Cell 28 (8): 1473-1482. 5 August 2021

Asymmetric opening of the homopentameric 5-HT(3A) serotonin receptor in lipid bilayers.
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Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
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A simple pressure-assisted method for MicroED specimen preparation.
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Nature Communications 12 (1): 5036. 19 August 2021

Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders.
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SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency.
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BMC Bioinformatics 22 (1): 368. 15 July 2021

An introduction to advanced targeted acquisition methods.
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High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
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Journal for ImmunoTherapy of Cancer 9 (7): e002410. 30 July 2021

The role of microbiota in primary sclerosing cholangitis and related biliary malignancies.
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Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML).
Agrawal, M. and Schwarz, P. and Giaimo, B.D. and Bedzhov, I. and Corbacioglu, A. and Weber, D. and Gaidzik, V.I. and Jahn, N. and Rücker, F.G. and Schroeder, T. and Kindler, T. and Wattad, M. and Götze, K. and Lübbert, M. and Salwender, H. and Ringhoffer, M. and Lange, E. and Koller, E. and Thol, F. and Heuser, M. and Ganser, A. and Bullinger, L. and Paschka, P. and Döhner, H. and Geiger, H. and Borggrefe, T. and Döhner, K. and Oswald, F.
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Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment.
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Current Opinion in Oncology 32 (2): 146-153. 1 March 2020

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Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways.
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medRxiv : 2020.08.31.20169946. 2 September 2020

Inter-individual and inter-strain differences in cognitive and social abilities of Dark Agouti and Wistar Han rats.
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Order and disorder: abnormal 3D chromatin organization in human disease.
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Briefings in Functional Genomics 19 (2): 128-138. March 2020

Early life stress regulates cardiac development through an IL4-glucocorticoid signaling balance.
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Cell Reports 33 (7): 108404. 17 November 2020

Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas.
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Clinical and Translational Oncology 22 (12): 2357-2363. December 2020

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
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Cell Reports 31 (5): 107611. 5 May 2020

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
Baccin, C. and Al-Sabah, J. and Velten, L. and Helbling, P.M. and Grünschläger, F. and Hernández-Malmierca, P. and Nombela-Arrieta, C. and Steinmetz, L.M. and Trumpp, A. and Haas, S.
Nature Cell Biology 22 (1): 38-48. January 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H. and Meyerson, W.U. and Dursi, L.J. and Wang, L.B. and Dong, G. and Liang, W.W. and Weerasinghe, A. and Li, S. and Li, Y. and Kelso, S. and Saksena, G. and Ellrott, K. and Wendl, M.C. and Wheeler, D.A. and Getz, G. and Simpson, J.T. and Gerstein, M.B. and Ding, Li
Nature Communications 11 (1): 4748. 21 September 2020

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability.
Barbosa, R.R. and Xu, A.Q. and D'Andrea, D. and Copley, F. and Patel, H. and Chakravarty, P. and Clear, A. and Calaminici, M. and Janz, M. and Zhang, B. and Schmidt-Supprian, M. and Wang, J. and Gribben, J.G. and Tooze, R. and Fitzgibbon, J. and Franzoso, G. and Rajewsky, K. and Calado, D.P.
bioRxiv : 2020.04.12.038414. 13 April 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting Histone H2A-K15 ubiquitination.
Bashir, S. and Dang, T. and Rossius, J. and Wolf, J. and Kuehn, R.
BMC Biotechnology 20 (1): 57. 23 October 2020

CD40 provides immune privilege to the bone marrow hematopoietic niche.
Bassani, B. and Gulino, A. and Portararo, P. and Botti, L. and Cappetti, B. and Chiodoni, C. and Bolli, N. and Ciciarello, M. and Joehrens, K. and Anagnostopoulos, I. and Na, I.K. and Curti, A. and Tripodo, C. and Colombo, M.P. and Sangaletti, S.
bioRxiv : 2020.08.10.243691. 10 August 2020

Unblending of transcriptional condensates in human repeat expansion disease.
Basu, S. and Mackowiak, S.D. and Niskanen, H. and Knezevic, D. and Asimi, V. and Grosswendt, S. and Geertsema, H. and Ali, S. and Jerković, I. and Ewers, H. and Mundlos, S. and Meissner, A. and Ibrahim, D.M. and Hnisz, D.
Cell 181 (5): 1062-1079. 28 May 2020

Establishment of kidney cancer organoid cultures.
Bauer, D. and Birchmeier, W. and Fendler, A.
Research Square : rs.3.pex-911. 12 May 2020

LoopDetect: comprehensive feedback loop detection in ordinary differential equation models.
Baum, K. and Wolf, J.
bioRxiv : 2020.11.15.383703. 17 November 2020

Analysing central metabolism in ultra-high resolution: at the crossroads of carbon and nitrogen.
Bayram, S. and Fürst, S. and Forbes, M. and Kempa, S.
Molecular Metabolism 33 : 38-47. 19 March 2020

Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia.
Becker, H. and Pfeifer, D. and Ihorst, G. and Pantic, M. and Wehrle, J. and Rüter, B.H. and Bullinger, L. and Hackanson, B. and Germing, U. and Kuendgen, A. and Platzbecker, U. and Döhner, K. and Ganser, A. and Hagemeijer, A. and Wijermans, P.W. and Döhner, H. and Duyster, J. and Lübbert, M.
Annals of Hematology 99 (7): 1551-1560. July 2020

Disentangling pro-mitotic signaling during cell cycle progression using time-resolved single-cell imaging.
Benary, M. and Bohn, S. and Lüthen, M. and Nolis, I.K. and Blüthgen, N. and Loewer, A.
Cell Reports 31 (2): 107514. 14 April 2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P. and Mishra, N. and Tran, F. and Bahmer, T. and Best, L. and Blase, J.I. and Bordoni, D. and Franzenburg, J. and Geisen, U. and Josephs-Spaulding, J. and Köhler, P. and Künstner, A. and Rosati, E. and Aschenbrenner, A.C. and Bacher, P. and Baran, N. and Boysen, T. and Brandt, B. and Bruse, N. and Dörr, J. and Dräger, A. and Elke, G. and Ellinghaus, D. and Fischer, J. and Forster, M. and Franke, A. and Franzenburg, S. and Frey, N. and Friedrichs, A. and Fuß, J. and Glück, A. and Hamm, J. and Hinrichsen, F. and Hoeppner, M.P. and Imm, S. and Junker, R. and Kaiser, S. and Kan, Y.H. and Knoll, R. and Lange, C. and Laue, G. and Lier, C. and Lindner, M. and Marinos, G. and Markewitz, R. and Nattermann, J. and Noth, R. and Pickkers, P. and Rabe, K.F. and Renz, A. and Röcken, C. and Rupp, J. and Schaffarzyk, A. and Scheffold, A. and Schulte-Schrepping, J. and Schunk, D. and Skowasch, D. and Ulas, T. and Wandinger, K.P. and Wittig, M. and Zimmermann, J. and Busch, H. and Hoyer, B.F. and Kaleta, C. and Heyckendorf, J. and Kox, M. and Rybniker, J. and Schreiber, S. and Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Berndt, N. and Egners, A. and Mastrobuoni, G. and Vvedenskaya, O. and Fragoulis, A. and Dugourd, A. and Bulik, S. and Pietzke, M. and Bielow, C. and van Gassel, R. and Olde Damink, S.W. and Erdem, M. and Saez-Rodriguez, J. and Holzhütter, H.G. and Kempa, S. and Cramer, T.
British Journal of Cancer 122 (2): 233-244. 21 January 2020

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Biederstädt, A. and Hassan, Z. and Schneeweis, C. and Schick, M. and Schneider, L. and Muckenhuber, A. and Hong, Y. and Siegers, G. and Nilsson, L. and Wirth, M. and Dantes, Z. and Steiger, K. and Schunck, K. and Langston, S. and Lenhof, H.P. and Coluccio, A. and Orben, F. and Slawska, J. and Scherger, A. and Saur, D. and Müller, S. and Rad, R. and Weichert, W. and Nilsson, J. and Reichert, M. and Schneider, G. and Keller, U.
Gut 69 (8): 1472-1482. August 2020

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B. and Schmidt, M. and Weisbach, H. and Gruska, I. and Vetter, B. and Imami, K. and Ostermann, E. and Brune, W. and Selbach, M. and Hagemeier, C. and Wiebusch, L.
Nature Communications 11 (1): 4845. 24 September 2020

VISOR: a versatile haplotype-aware structural variant simulator for short- and long-read sequencing.
Bolognini, D. and Sanders, A. and Korbel, J.O. and Magi, A. and Benes, V. and Rausch, T.
Bioinformatics 36 (4): 1267-1269. 15 February 2020

Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J. and Goergen, H. and Keller, U. and Meissner, J. and Ordemann, R. and Halbsguth, T.V. and Sasse, S. and Sökler, M. and Kerkhoff, A. and Mathas, S. and Hüttmann, A. and Bormann, M. and Zimmermann, A. and Mettler, J. and Fuchs, M. and von Tresckow, B. and Baues, C. and Rosenwald, A. and Klapper, W. and Kobe, C. and Borchmann, P. and Engert, A.
JAMA Oncology 6 (6): 872-880. June 2020

mRNAs, proteins and the emerging principles of gene expression control.
Buccitelli, C. and Selbach, M.
Nature Reviews Genetics 21 (10): 630-644. October 2020

Decoding and targeting the molecular basis of MACC1-driven metastatic spread: lessons from big data mining and clinical-experimental approaches.
Budczies, J. and Kluck, K. and Walther, W. and Stein, U.
Seminars in Cancer Biology 60 : 365-379. February 2020

NF-κB signaling in tanycytes mediates inflammation-induced anorexia.
Böttcher, M. and Müller-Fielitz, H. and Sundaram, S.M. and Gallet, S. and Neve, V. and Shionoya, K. and Zager, A. and Quan, N. and Liu, X. and Schmidt-Ullrich, R. and Haenold, R. and Wenzel, J. and Blomqvist, A. and Engblom, D. and Prevot, V. and Schwaninger, M.
Molecular Metabolism 39 : 101022. September 2020

Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, P. and Muñoz-Fuentes, V. and Murray, S.A. and Dickinson, M.E. and Bucan, M. and Nutter, L.M.J. and Peterson, K.A. and Haselimashhadi, H. and Flenniken, A.M. and Morgan, H. and Westerberg, H. and Konopka, T. and Hsu, C.W. and Christiansen, A. and Lanza, D.G. and Beaudet, A.L. and Heaney, J.D. and Fuchs, H. and Gailus-Durner, V. and Sorg, T. and Prochazka, J. and Novosadova, V. and Lelliott, C.J. and Wardle-Jones, H. and Wells, S. and Teboul, L. and Cater, H. and Stewart, M. and Hough, T. and Wurst, W. and Sedlacek, R. and Adams, D.J. and Seavitt, J.R. and Tocchini-Valentini, G. and Mammano, F. and Braun, R.E. and McKerlie, C. and Herault, Y. and de Angelis, M.H. and Mallon, A.M. and Lloyd, K.C.K. and Brown, S.D.M. and Parkinson, H. and Meehan, T.F. and Smedley, D.
Nature Communications 11 (1): 655. 31 January 2020

Genomic basis for RNA alterations in cancer.
Calabrese, C. and Davidson, N.R. and Demircioğlu, D. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, Q. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Huska, M.R. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
Nature 578 (7793): 129-136. 6 February 2020

Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L. and Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27 (8): 717-725. August 2020

Single-cell lineage tracing approaches in hematology research: technical considerations.
Carrelha, J. and Lin, D.S. and Rodriguez-Fraticelli, A.E. and Luis, T.C. and Wilkinson, A.C. and Cabezas-Wallscheid, N. and Tremblay, C.S. and Haas, S.
Experimental Hematology 89 : 26-36. September 2020

Structure of RyR1 in native membranes.
Chen, W. and Kudryashev, M.
EMBO Reports 21 (5): e49891. 6 May 2020

What is extrachromosomal circular DNA and what does it do?
Chiu, R.W.K. and Dutta, A. and Henssen, A.G. and Lo, Y.M.D. and Mischel, P. and Regenberg, B.
Clinical Chemistry 66 (6): 754-759. June 2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C. and Müller, M. and Pak, H.S. and Harnett, D. and Huber, F. and Grun, D. and Leleu, M. and Auger, A. and Arnaud, M. and Stevenson, B.J. and Michaux, J. and Bilic, I. and Hirsekorn, A. and Calviello, L. and Simó-Riudalbas, L. and Planet, E. and Lubiński, J. and Bryśkiewicz, M. and Wiznerowicz, M. and Xenarios, I. and Zhang, L. and Trono, D. and Harari, A. and Ohler, U. and Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11 (1): 1293. 10 March 2020

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.
Chouhan, O.P. and Roske, Y. and Heinemann, U. and Biswas, S.
Biochemical and Biophysical Research Communications 523 (2): 287-292. 5 March 2020

Endothelial damage and dysfunction in acute graft-versus-host disease.
Cordes, S. and Mokhtari, Z. and Bartosova, M. and Mertlitz, S. and Riesner, K. and Shi, Y. and Mengwasser, J. and Kalupa, M. and McGeary, A. and Schleifenbaum, J. and Schrezenmeier, J. and Bullinger, L. and Diaz-Ricart, M. and Palomo, M. and Carrreras, E. and Beutel, G. and Schmitt, C.P. and Beilhack, A. and Penack, O.
Haematologica 106 (8): 2147-2160. 1 August 2020

A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.
Coscia, F. and Doll, S. and Bech, J.M. and Schweizer, L. and Mund, A. and Lengyel, E. and Lindebjerg, J. and Madsen, G.I. and Moreira, J.M. and Mann, M.
Journal of Pathology 251 (1): 100-112. May 2020

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G. and Roeschert, I. and Prinz, F. and Baluapuri, A. and Silveira Vidal, R. and Schülein-Völk, C. and Chang, Y.C. and Ade, C.P. and Mastrobuoni, G. and Girard, C. and Kumar, A. and Wortmann, L. and Walz, S. and Lührmann, R. and Kempa, S. and Kuster, B. and Wolf, E. and Mumberg, D. and Eilers, M.
Molecular Cell 77 (6): 1322-1339. 19 March 2020

SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency.
Costa, V.R.M. and Pfeuffer, J. and Louloupi, A. and Ørom, U.A.V. and Piro, R.M.
bioRxiv : 2020.10.12.318808. 12 October 2020

Restoring treatment response in colorectal cancer cells by targeting MACC1-dependent ABCB1 expression in combination therapy.
Dahlmann, M. and Werner, R. and Kortüm, B. and Kobelt, D. and Walther, W. and Stein, U.
Frontiers in Oncology 10 : 599. 23 April 2020

Novel targets of protoporphyrin-IX determined by gene expression analysis.
Dai, Y. and Kemmner, W.
International Journal of Clinical Oncology and Cancer Research 5 (3): 56-64. September 2020

The pierced lasso topology leptin has a bolt on dynamic domain composed by the disordered loops I and III.
Danielsson, J. and Noel, J.K. and Simien, J.M. and Duggan, B.M. and Oliveberg, M. and Onuchic, J.N. and Jennings, P.A. and Haglund, E.
Journal of Molecular Biology 432 (9): 3050-3063. 17 April 2020

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E.W. and Lebedin, M. and de la Rosa, K. and Kühn, R.
bioRxiv : 2020.05.11.088252. 12 May 2020

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Balasubramanian, S. and Sundaravinayagam, D. and Graf, R. and Rahjouei, A. and Driesner, M. and Keller, L. and Janz, M. and Akalin, A. and Di Virgilio, M.
bioRxiv : 2020.01.30.917062. 31 January 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P. and Newman, A.G. and Singh, M. and Hinz, M. and Szczepek, M. and Krüger, C. and Adalbert, R. and Dzaye, O. and Trimbuch, T. and Wallach, T. and Kleinau, G. and Derkow, K. and Richard, B.C. and Schipke, C. and Scheidereit, C. and Stachelscheid, H. and Golenbock, D. and Peters, O. and Coleman, M. and Heppner, F.L. and Scheerer, P. and Tarabykin, V. and Ruprecht, K. and Izsvák, Z. and Mayer, J. and Lehnardt, S.
JCI Insight 5 (7): e131093. 9 April 2020

HMGXB4 targets Sleeping Beauty transposition to vertebrate germinal stem sells.
Devaraj, A. and Singh, M. and Narayanavari, S. and Yong, G. and Wang, J. and Wang, J. and Becker, M. and Walisko, O. and Schorn, A. and Cseresznyés, Z. and Grzela, D. and Raskó, T. and Selbach, M. and Ivics, Z. and Izsvák, Z.
bioRxiv : 2020.06.15.145656. 15 June 2020

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.
Dias D'Andréa, E. and Roske, Y. and de Oliveira, G.A.P. and Cremer, N. and Diehl, A. and Schmieder, P. and Heinemann, U. and Oschkinat, H. and Ricardo Pires, J.
Journal of Structural Biology 211 (2): 107536. 1 August 2020

Deep learning for prediction of population health costs.
Drewe-Boss, P. and Enders, D. and Walker, J. and Ohler, U.
arXiv : 2003.03466. 10 March 2020

Functional classification of TP53 mutations in acute myeloid leukemia.
Dutta, S. and Pregartner, G. and Rücker, F.G. and Heitzer, E. and Zebisch, A. and Bullinger, L. and Berghold, A. and Döhner, K. and Sill, H.
Cancers 12 (3): 637. 10 March 2020

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin.
Dyring-Andersen, B. and Løvendorf, M.B. and Coscia, F. and Santos, A. and Møller, L.B.P. and Colaço, A.R. and Niu, L. and Bzorek, M. and Doll, S. and Andersen, J.L. and Clark, R.A. and Skov, L. and Teunissen, M.B.M. and Mann, M.
Nature Communications 11 (1): 5587. 5 November 2020

Longtime outcome after intraosseous application of autologous mesenchymal stromal cells in pediatric patients and young adults with avascular necrosis after steroid or chemotherapy.
Döring, M. and Kluba, T. and Cabanillas Stanchi, K.M. and Kahle, P. and Lenglinger, K. and Tsiflikas, I. and Treuner, C. and Vaegler, M. and Mezger, M. and Erbacher, A. and Schumm, M. and Lang, P. and Handgretinger, R. and Müller, I.
Stem Cells and Development 29 (13): 811-822. July 2020

Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.
Edelmann, J. and Holzmann, K. and Tausch, E. and Saunderson, E.A. and Jebaraj, B.M.C. and Steinbrecher, D. and Dolnik, A. and Blätte, T.J. and Landau, D.A. and Saub, J. and Estenfelder, S. and Ibach, S. and Cymbalista, F. and Leblond, V. and Delmer, A. and Bahlo, J. and Robrecht, S. and Fischer, K. and Goede, V. and Bullinger, L. and Wu, C.J. and Mertens, D. and Ficz, G. and Gribben, J.G. and Hallek, M. and Döhner, H. and Stilgenbauer, S.
Haematologica 105 (5): 1379-1390. May 2020

Age attenuates the T-type Ca(V) 3.2-RyR axis in vascular smooth muscle.
Fan, G. and Kaßmann, M. and Cui, Y. and Matthaeus, C. and Kunz, S. and Zhong, C. and Zhu, S. and Xie, Yu and Tsvetkov, D. and Daumke, O. and Huang, Yu and Gollasch, M.
Aging Cell 19 (4): e13134. April 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

CD8-specific designed ankyrin repeat proteins improve selective gene delivery into human and primate T lymphocytes.
Frank, A.M. and Weidner, T. and Brynza, J. and Uckert, W. and Buchholz, C.J. and Hartmann, J.
Human Gene Therapy 31 (11-12): 679-691. June 2020

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes.
Gainullina, A. and Huang, L.H. and Todorov, H. and Kim, K. and Yng, L.S. and Kent, A. and Jia, B. and Seddu, K. and Krchma, K. and Wu, J. and Crozat, K. and Tomasello, E. and Narang, V. and Dress, R. and See, P. and Scott, C. and Gibbings, S. and Bajpai, G. and Desai, J.V. and Maier, B. and This, S. and Wang, P. and Aguilar, S.V. and Poupel, L. and Dussaud, S. and Zhou, T.A. and Angeli, V. and Blander, J.M. and Choi, K. and Dalod, M. and Dzhagalov, I. and Gautier, E.L. and Jakubzick, C. and Lavine, K. and Lionakis, M.S. and Paidassi, H. and Sieweke, M.H. and Ginhoux, Fl. and Guilliams, M. and Benoist, C. and Merad, M. and Randolph, G.J. and Sergushichev, A. and Artyomov, M.N.
bioRxiv : 2020.07.15.204388. 16 July 2020

A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
Galupa, R. and Nora, E.P. and Worsley-Hunt, R. and Picard, C. and Gard, C. and van Bemmel, J.G. and Servant, N. and Zhan, Y. and El Marjou, F. and Johanneau, C. and Diabangouaya, P. and Le Saux, A. and Lameiras, S. and Pipoli da Fonseca, J. and Loos, F. and Gribnau, J. and Baulande, S. and Ohler, U. and Giorgetti, L. and Heard, E.
Molecular Cell 77 (2): 352-367. 16 January 2020

Mechanistic basis for motor-driven membrane constriction by dynamin.
Ganichkin, O. and Vancraenenbroeck, R. and Rosenblum, G. and Hofmann, H. and Mikhailov, A.S. and Daumke, O. and Noel, J.K.
bioRxiv : 2020.09.10.289546. 11 September 2020

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy.
García, H.D. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Pusch, F.F. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Schulte, J.H. and Haase, K. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
bioRxiv : 2020.12.04.411413. 2020

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes.
Garipler, G. and Lu, C. and Morrissey, A. and Lopez-Zepeda, L.S. and Vidal, S.E. and Aydin, B. and Stadtfeld, M. and Ohler, U. and Mahony, S. and Sanjana, N.E. and Mazzoni, E.O.
bioRxiv : 2020.11.23.391771. 23 November 2020

pH-dependent protonation of surface carboxylate groups in PsbO enables local buffering and triggers structural changes.
Gerland, L. M. and Friedrich, D. and Hopf, L. and Donovan, E. and Wallmann, A. and Erdmann, N. and Diehl, A. and Bommer, M. and Buzar, K. and Ibrahim, M. and Schmieder, P. and Dobbek, H. and Zouni, A. and Bondar, A.-N. and Dau, H. and Oschkinat, H.
ChemBioChem 21 (11): 1597-1604. 2 June 2020

Deep neural networks for interpreting RNA-binding protein target preferences.
Ghanbari, M. and Ohler, U.
Genome Research 30 (2): 214-226. February 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. and Wagner, L.K. and Li, H. and Dörr, D. and Medaglia, C. and Paul, F. and Shemer, A. and Jung, S. and Yona, S. and Mack, M. and Leutz, A. and Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G. and Custodio, J. and Kallas, T. and Agostini, F. and Wernersson, E. and Spanjaard, B. and Mota, A. and Kolbeinsdottir, S. and Gelali, E. and Crosetto, N. and Bienko, M.
Nature Biotechnology 38 (10): 1184-1193. October 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M. and Menzel, L. and Grau, M. and Vion, A.C. and Anagnostopoulos, I. and Zapukhlyak, M. and Gerlach, K. and Kammertöns, T. and Hehlgans, T. and Zschummel, M. and Lenz, G. and Gerhardt, H. and Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus.
Gonzalez-Perez, A.C. and Stempel, M. and Wyler, E. and Urban, C. and Piras, A. and Hennig, T. and Heim, A. and Landthaler, M. and Pichlmair, A. and Erhard, F. and Dölken, L. and Brinkmann, M.M.
bioRxiv : 2020.09.15.297804. 17 September 2020

MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
bioRxiv : 2020.11.19.389528. 19 November 2020

The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia.
Grasedieck, S. and Ruess, C. and Krowiorz, K. and Lux, S. and Pochert, N. and Schwarzer, A. and Klusmann, J.H. and Jongen-Lavrencic, M. and Herold, T. and Bullinger, L. and Pollack, J.R. and Rouhi, A. and Kuchenbauer, F.
Haematologica 105 (9): e448-e453. September 2020

Specific T-cell immune responses against colony-forming cells including leukemic progenitor cells of AML patients were increased by immune checkpoint inhibition.
Greiner, J. and Götz, M. and Hofmann, S. and Schrezenmeier, H. and Wiesneth, M. and Bullinger, L. and Döhner, H. and Schneider, V.
Cancer Immunology Immunotherapy 69 (4): 629-640. April 2020

Ensuring center quality, proper patient selection and fair access to chimeric antigen receptor T-cell therapy: position statement of the Austrian CAR-T Cell Network.
Greinix, H.T. and Attarbaschi, A. and Girschikofsky, M. and Greil, R. and Holter, W. and Neumeister, P. and Peters, C. and Petzer, A. and Rudzki, J. and Schlenke, P. and Schmitt, C.A. and Schwinger, W. and Wolf, D. and Worel, N. and Jaeger, U.
memo: Magazine of European Medical Oncology 13 (1): 27-31. March 2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J. and Heuberger, J. and Vidal, R. and Goveas, N. and Kosel, F. and Berenguer-Llergo, A. and Kranz, A. and Wulf-Goldenberg, A. and Behrens, D. and Melcher, B. and Sauer, S. and Vieth, M. and Batlle, E. and Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Mechanism of virus attenuation by codon pair deoptimization.
Groenke, N. and Trimpert, J. and Merz, S. and Conradie, A.M. and Wyler, E. and Zhang, H. and Hazapis, O.G. and Rausch, S. and Landthaler, M. and Osterrieder, N. and Kunec, D.
Cell Reports 31 (4): 107586. 28 April 2020

Epigenetic regulator function through mouse gastrulation.
Grosswendt, S. and Kretzmer, H. and Smith, Z.D. and Kumar, A.S. and Hetzel, S. and Wittler, L. and Klages, S. and Timmermann, B. and Mukherji, S. and Meissner, A.
Nature 584 (7819): 102-108. 6 August 2020

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S. and Hopf, L.V.M. and Bock-Bierbaum, T. and Lally, C.C.M. and Spahn, C.M.T. and Daumke, O.
Nature Communications 11 (1): 5506. 2 November 2020

Sarcoma treatment in the era of molecular medicine.
Grünewald, T.G.P. and Alonso, M. and Avnet, S. and Banito, A. and Burdach, S. and Cidre-Aranaz, F. and Di Pompo, G. and Distel, M. and Dorado-Garcia, H. and Garcia-Castro, J. and González-González, L. and Grigoriadis, A.E. and Kasan, M. and Koelsche, C. and Krumbholz, M. and Lecanda, F. and Lemma, S. and Longo, D.L. and Madrigal-Esquivel, C. and Morales-Molina, Á. and Musa, J. and Ohmura, S. and Ory, B. and Pereira-Silva, M. and Perut, F. and Rodriguez, R. and Seeling, C. and Al Shaaili, N. and Shaabani, S. and Shiavone, K. and Sinha, S. and Tomazou, E.M. and Trautmann, M. and Vela, M. and Versleijen-Jonkers, Y.M.H. and Visgauss, J. and Zalacain, M. and Schober, S.J. and Lissat, A. and English, W.R. and Baldini, Ni. and Heymann, D.
EMBO Molecular Medicine 12 : e11131. 6 November 2020

Saffron crudes and compounds restrict MACC1-dependent cell proliferation and migration of colorectal cancer cells.
Güllü, N. and Kobelt, D. and Brim, H. and Rahman, S. and Timm, L. and Smith, J. and Soleimani, A. and Di Marco, S. and Bisti, S. and Ashktorab, H. and Stein, U.
Cells 9 (8): 1829. 3 August 2020

Hematopoietic stem cells in health and disease - insights from single-cell multi-omic approaches.
Haas, S.
Current Stem Cell Reports 6 (3): 67-76. September 2020

Karzinogenese: Big Bang oder kontinuierliche Evolution?
Haase, K. and Schwarz, R.F.
BIOspektrum 26 (7): 718-720. November 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A. and Kny, M. and Pablo-Tortola, C. and Todiras, M. and Willenbrock, M. and Schmidt, S. and Schmoeckel, K. and Jorde, I. and Nowak, M. and Jarosch, E. and Sommer, T. and Bröker, B.M. and Felix, S.B. and Scheidereit, C. and Weber-Carstens, S. and Butter, C. and Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Microbe-driven genotoxicity in gastrointestinal carcinogenesis.
Hartl, K. and Sigal, M.
International Journal of Molecular Sciences 21 (20): 7439. 2 October 2020

High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Hehlmann, R. and Voskanyan, A. and Lauseker, M. and Pfirrmann, M. and Kalmanti, L. and Rinaldetti, S. and Kohlbrenner, K. and Haferlach, C. and Schlegelberger, B. and Fabarius, A. and Seifarth, W. and Spieß, B. and Wuchter, P. and Krause, S. and Kolb, H.J. and Neubauer, A. and Hossfeld, D.K. and Nerl, C. and Gratwohl, A. and Baerlocher, G.M. and Burchert, A. and Brümmendorf, T.H. and Hasford, J. and Hochhaus, A. and Saußele, S. and Baccarani, M.
Leukemia 34 (8): 2074-2086. August 2020

Symmetry in nucleic-acid double helices.
Heinemann, U. and Roske, Y.
Symmetry 12 (5): 737. 5 May 2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M.E. and Ali, S. and Chamorro Gonzalez, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Dorado Garcia, H. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Keskeny, C. and Chen, C.Y. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M.I. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
Nature Communications 11 (1): 5823. 16 November 2020

CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
Herhaus, P. and Lipkova, J. and Lammer, F. and Yakushev, I. and Vag, T. and Slotta-Huspenina, J. and Habringer, S. and Lapa, C. and Pukrop, T. and Hellwig, D. and Wiestler, B. and Buck, A.K. and Deckert, M. and Wester, H.J. and Bassermann, F. and Schwaiger, M. and Weber, W.A. and Menze, B. and Keller, U.
Journal of Nuclear Medicine 61 (12): 1765-1771. 1 December 2020

Final results of a phase I/II trial of the combination Bendamustine and Rituximab with Temsirolimus (BeRT) in relapsed mantle cell lymphoma and follicular lymphoma.
Hess, G. and Wagner, K. and Keller, U. and La Rosee, P. and Atta, J. and Hübel, K. and Lerchenmueller, C. and Schoendube, D. and Witzens-Harig, M. and Ruckes, C. and Medler, C. and van Oordt, C. and Klapper, W. and Theobald, M. and Dreyling, M.
HemaSphere 4 (3): e398. June 2020

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness.
Ho, J.S.Y. and Low, D. and Schwarz, M. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J. and Wollman, H. and Chen, L. and An, O. and Chan, T.H.M. and Hickman, A.H. and Zheng, S. and Roudko, V. and Chen, S. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Marazzi, I. and Serresi, M. and Gargiulo, G. and Oliviero, S. and Wee, D.K.B. and Guccione, E.
bioRxiv : 2020.06.17.157537. 18 June 2020

FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.
Hoffmann, S. and Pentakota, S. and Mund, A. and Haahr, P. and Coscia, F. and Gallo, M. and Mann, M. and Taylor, N.M. and Mailand, N.
EMBO Reports 21 (10): e50662. 5 October 2020

MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma.
Hohmann, T. and Hohmann, U. and Kolbe, M.R. and Dahlmann, M. and Kobelt, D. and Stein, U. and Dehghani, F.
Cell Communication and Signaling 18 (1): 85. 5 June 2020

Spatio-temporal mRNA dynamics in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
bioRxiv : 020.11.19.389809. 20 November 2020

Authentication of primary murine cell lines by a microfluidics-based lab-on-chip system.
Hong, Y. and Singh, N. and Bamopoulos, S. and Gjerga, E. and Schmalbrock, L.K. and Balabanian, K. and Schick, M. and Keller, U. and Wirth, M.
Biomedicines 8 (12): 590. 9 December 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

Local and central evaluation of HER2 positivity and clinical outcome in advanced gastric and gastroesophageal cancer: results from the AGMT GASTRIC-5 Registry.
Huemer, F. and Weiss, L. and Regitnig, P. and Winder, T. and Hartmann, B. and Thaler, J. and Piringer, G. and Schmitt, C.A. and Eisterer, W. and Gänzer, H. and Wüstner, Al. and Andel, J. and Jagdt, B. and Ulmer, H. and Greil, R. and Wöll, E.
Journal of Clinical Medicine 9 (4): 935. 29 March 2020

The International Virus Bioinformatics Meeting 2020.
Hufsky, F. and Beerenwinkel, N. and Meyer, I.M. and Roux, S. and Cook, G.M. and Kinsella, C.M. and Lamkiewicz, K. and Marquet, M. and Nieuwenhuijse, D.F. and Olendraite, I. and Paraskevopoulou, S. and Young, F. and Dijkman, R. and Ibrahim, B. and Kelly, J. and Le Mercier, P. and Marz, M. and Ramette, A. and Thiel, V.
Viruses 12 (12): 1398. 6 December 2020

Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia.
In't Hout, F.E.M. and Gerritsen, M. and Bullinger, L. and Van der Reijden, B.A. and Huls, G. and Vellenga, E. and Jansen, J.H.
Haematologica 105 (9): e454-457. 1 September 2020

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.
Jahn, N. and Terzer, T. and Sträng, E. and Dolnik, A. and Cocciardi, S. and Panina, E. and Corbacioglu, A. and Herzig, J. and Weber, D. and Schrade, A. and Götze, K. and Schröder, T. and Lübbert, M. and Wellnitz, D. and Koller, E. and Schlenk, R.F. and Gaidzik, V.I. and Paschka, P. and Rücker, F.G. and Heuser, M. and Thol, F. and Ganser, A. and Benner, A. and Döhner, H. and Bullinger, L. and Döhner, K.
Blood Advances 4 (24): 6342-6352. 22 December 2020

Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.
Jammrath, J. and Reim, I. and Saumweber, H.
PLoS ONE 15 (5): e0233719. 29 May 2020

A randomized open label phase-II clinical trial with or without infusion of plasma from subjects after convalescence of SARS-CoV-2 infection in high-risk patients with confirmed severe SARS-CoV-2 disease (RECOVER): a structured summary of a study protocol for a randomised controlled trial.
Janssen, M. and Schäkel, U. and Djuka Fokou, C. and Krisam, J. and Stermann, J. and Kriegsmann, K. and Haberbosch, I. and Novotny, J.P. and Weber, S. and Vehreschild, M. and Bornhäuser, M. and Bullinger, L. and Schmitt, M. and Liebregts, T. and Dreger, P. and Lorenz, H.M. and Plaszczyca, A. and Bartenschlager, R. and Müller, B. and Kräusslich, H.G. and Halama, N. and Jäger, D. and Schlenk, R.F. and Leo, A. and Meuer, S. and Weigand, M.A. and Motsch, J. and Merle, U. and Denkinger, C.M. and Müller-Tidow, C.
Trials 21 (1): 828. 6 October 2020

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K. and Schnöder, T.M. and Perner, F. and Herzog, C. and Meiler, A. and Krishnamoorthy, G. and Huber, N. and Mohr, J. and Edelmann-Stephan, B. and Austin, R. and Brandt, S. and Palandri, F. and Schröder, N. and Isermann, B. and Edlich, F. and Sinha, A.U. and Ungelenk, M. and Hübner, C.A. and Zeiser, R. and Rahmig, S. and Waskow, C. and Coldham, I. and Ernst, T. and Hochhaus, A. and Jilg, S. and Jost, P.J. and Mullally, A. and Bullinger, L. and Mertens, P.R. and Lane, S.W. and Mann, M. and Heidel, F.H.
Nature 588 (7836): 157-163. 3 December 2020

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions.
Jeuthe, S. and Kemna, J. and Kemna, C.P. and Zocholl, D. and Klopfleisch, R. and Palme, R. and Kirschbaum, C. and Thoene-Reineke, C. and Kammertoens, T.
PLoS ONE 15 (9): e0239231. 30 September 2020

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel.
Jiang, S. and Penack, O. and Terzer, T. and Schult, D. and Majer-Lauterbach, J. and Radujkovic, A. and Blau, I.W. and Bullinger, L. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Haematologica 106 (2): 446-453. February 2020

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.
Jumaa, H. and Caganova, M. and McAllister, E.J. and Hoenig, L. and He, X. and Saltukoglu, D. and Brenker, K. and Köhler, M. and Leben, R. and Hauser, A.E. and Niesner, R. and Rajewsky, K. and Reth, M. and Jellusova, J.
Life Science Alliance 3 (6): e202000700. June 2020

Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis.
Kalogirou, C. and Ellinger, J. and Kristiansen, G. and Hatzichristodoulou, G. and Kübler, H. and Kneitz, B. and Busch, J. and Fendler, A.
Translational Andrology and Urology 9 (3): 1314-1322. June 2020

"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T. and Kemna, J. and Leisegang, M.
EMBO Molecular Medicine 12 (2): e11801. 7 February 2020

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
Kapp-Schwoerer, S. and Weber, D. and Corbacioglu, A. and Gaidzik, V.I. and Paschka, P. and Krönke, J. and Theis, F. and Rücker, F.G. and Teleanu, M.V. and Panina, E. and Jahn, N. and Herzig, J. and Kubanek, L. and Schrade, A. and Göhring, G. and Fiedler, W. and Kindler, T and Schroeder, T. and Mayer, K.T. and Lübbert, M. and Wattad, M. and Götze, K.S. and Horst, H.A. and Koller, E. and Wulf, G. and Schleicher, J. and Bentz, M. and Krauter, J. and Bullinger, L. and Krzykalla, J. and Benner, A. and Schlenk, R.F. and Thol, F. and Heuser, M. and Ganser, A. and Döhner, H and Döhner, K.
Blood 136 (26): 3041-3050. 24 December 2020

Single cell RNA-sequencing-based analysis of CD4(+) T-cell subset-specific susceptibility to transcriptional modulation by HIV-1 latency-reversing agents.
Kazmierski, J. and Postmus, D. and Wyler, E. and Fischer, C. and Jansen, J. and Meixenberger, K. and Vitcetz, S.N. and Sohn, M. and Sauer, S. and Bannert, N. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.05.04.075119. 5 May 2020

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.
Kim, H. and Kim, H. and Feng, Y. and Li, Y. and Tamiya, H. and Tocci, S. and Ronai, Z.A.
Science Translational Medicine 12 (551): eaaz5683. 8 July 2020

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim, H. and Nguyen, N.P. and Turner, K. and Wu, S. and Gujar, A.D. and Luebeck, J. and Liu, J. and Deshpande, V. and Rajkumar, U. and Namburi, S. and Amin, S.B. and Yi, E. and Menghi, F. and Schulte, J.H. and Henssen, A.G. and Chang, H.Y. and Beck, C.R. and Mischel, .S. and Bafna, V. and Verhaak, R.G.W.
Nature Genetics 52 (9): 891-897. September 2020

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer.
Klinghammer, K. and Politz, O. and Eder, T. and Otto, R. and Raguse, J.D. and Albers, A. and Kaufmann, A. and Tinhofer, I. and Hoffmann, J. and Keller, U. and Keilholz, U.
Oncotarget 11 (41): 3688-3697. 13 October 2020

Small ones to fight a big problem-intervention of cancer metastasis by small molecules.
Kobelt, D. and Dahlmann, M. and Dumbani, M. and Güllü, N. and Kortüm, B. and Vílchez, M.E.A. and Stein, U. and Walther, W.
Cancers 12 (6): 1454. 3 June 2020

Pro-inflammatory TNF-α and IFN-γ promote tumor growth and metastasis via induction of MACC1.
Kobelt, D. and Zhang, C. and Clayton-Lucey, I.A. and Glauben, R. and Voss, C. and Siegmund, B. and Stein, U.
Frontiers in Immunology 11 : 980. 27 May 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Konrath, F. and Mittermeier, A. and Cristiano, E. and Wolf, J. and Loewer, A.
PLoS Computational Biology 16 (6): e1007901. 26 June 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Vieira-Vieira, C.H. and Schaub, T. and Harnett, D. and Münster-Wandowski, A. and Bürger, J. and Zinnall, U. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Beule, D. and Landthaler, M. and Mielke, T. and Tarabykin, V. and Vida, I. and Selbach, M. and Spahn, C.M.T.
bioRxiv : 2020.02.08.939488. 10 February 2020

Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
Kroschinsky, F. and Middeke, J.M. and Janz, M. and Lenz, G. and Witzens-Harig, M. and Bouabdallah, R. and La Rosée, P. and Viardot, A. and Salles, G. and Kim, S.J. and Kim, T.M. and Ottmann, O. and Chromik, J. and Quinson, A.M. and von Wangenheim, U. and Burkard, U. and Berk, A. and Schmitz, N.
Investigational New Drugs 38 (5): 1472-1482. October 2020

Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations.
Kutle, I. and Szymańska-de Wijs, K.M. and Bogdanow, B. and Cuvalo, B. and Steinbrück, L. and Jonjić, S. and Wagner, K. and Niedenthal, R. and Selbach, M. and Wiebusch, L. and Dezeljin, M. and Messerle, M.
Journal of Virology 94 (20): e00574-20. October 2020

Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting.
Lang, K.M. and Harrison, K.L. and Williamson, P.R. and Huntly, B.J.P. and Ossenkoppele, G. and Geissler, J. and Bereczky, T. and Hernández-Rivas, J.M. and Chevrou-Séverac, H. and Goodbody, R. and Schulze-Rath, R. and Bullinger, L.
Trials 21 (1): 437. 27 May 2020

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates.
Langer, H.T. and Afzal, S. and Kempa, S. and Spuler, S.
Scientific Reports 10 : 1908. 5 February 2020

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.
Lankes, K. and Hassan, Z. and Doffo, M.J. and Schneeweis, C. and Lier, S. and Öllinger, R. and Rad, R. and Krämer, O.H. and Keller, U. and Saur, D. and Reichert, M. and Schneider, G. and Wirth, M.
bioRxiv : 2020.07.01.182162. 2 July 2020

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.
Lankes, K. and Hassan, Z.Z. and Doffo, M.J. and Schneeweis, C. and Lier, S. and Öllinger, R. and Rad, R. and Krämer, O.H. and Keller, U. and Saur, D. and Reichert, M. and Schneider, G. and Wirth, M.
Molecular Oncology 14 (12): 3048-3064. December 2020

Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Lauber, C. and Correia, N. and Trumpp, A. and Rieger, M.A. and Dolnik, A. and Bullinger, L. and Roeder, I. and Seifert, M.
Scientific Reports 10 (1): 12761. 29 July 2020

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S. and Simões, M. and Hu, B. and Alameldeen, A.M.A. and Czajkowski, M.T. and Meyer, A.M. and Ferrara, F. and Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

The chloroplast RNA binding protein CP31A has a preference for mRNAs encoding the subunits of the chloroplast NAD(P)H dehydrogenase complex and is required for their accumulation.
Lenzen, B. and Rühle, T. and Lehniger, M.K. and Okuzaki, A. and Labs, M. and Muino, J.M. and Ohler, U. and Leister, D. and Schmitz-Linneweber, C.
International Journal of Molecular Sciences 21 (16): 5633. 6 August 2020

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C. and Ritterhoff, T. and Weber, A. and Janowska, M.K. and Mustroph, M. and Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Social media big data-based research on the influencing factors of insomnia and spatiotemporal evolution.
Liu, Y. and Luo, Q. and Shen, H. and Zhuang, S. and Xu, C. and Dong, Y. and Sun, Y. and Wang, S. and Deng, H.
IEEE Access 8 : 41516-41529. 28 February 2020

Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.
Loughran, S.J. and Haas, S. and Wilkinson, A.C. and Klein, A.M. and Brand, M.
Experimental Hematology 88 : 1-6. August 2020

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone.
Lutsik, P. and Baude, A. and Mancarella, D. and Öz, S. and Kühn, A. and Toth, R. and Hey, J. and Toprak, U.H. and Lim, J. and Nguyen, V.H. and Jiang, C. and Mayakonda, A. and Hartmann, M. and Rosemann, F. and Breuer, K. and Vonficht, D. and Grünschläger, F. and Lee, S. and Schuhmacher, M.K. and Kusevic, D. and Jauch, A. and Weichenhan, D. and Zustin, J. and Schlesner, M. and Haas, S. and Park, J.H. and Park, Y.J. and Oppermann, U. and Jeltsch, A. and Haller, F. and Fellenberg, J. and Lindroth, A.M. and Plass, C.
Nature Communications 11 (1): 5414. 27 October 2020

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S. and Lim, E.L. and Horswell, S. and Haase, K. and Huebner, A. and Dietzen, M. and Mourikis, T.P. and Watkins, T.B.K. and Rowan, A. and Dewhurst, S.M. and Birkbak, N.J. and Wilson, G.A. and Van Loo, P. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature Genetics 52 (3): 283-293. March 2020

Single-cell strand sequencing of a macaque genome reveals multiple nested inversions and breakpoint reuse during primate evolution.
Maggiolini, F.A.M. and Sanders, A.D. and Shew, C.J. and Sulovari, A. and Mao, Y. and Puig, M. and Catacchio, C.R. and Dellino, M. and Palmisano, D. and Mercuri, L. and Bitonto, M. and Porubský, D. and Cáceres, M. and Eichler, E.E. and Ventura, M. and Dennis, M.Y. and Korbel, J.O. and Antonacci, F.
Genome Research 30 (11): 1680-1693. November 2020

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Marchetto, A. and Ohmura, S. and Orth, M.F. and Knott, M.M.L. and Colombo, M.V. and Arrigoni, C. and Bardinet, V. and Saucier, D. and Wehweck, F.S. and Li, J. and Stein, S. and Gerke, J.S. and Baldauf, M.C. and Musa, J. and Dallmayer, M. and Romero-Pérez, L. and Hölting, T.L.B. and Amatruda, J.F. and Cossarizza, A. and Henssen, A.G. and Kirchner, T. and Moretti, M. and Cidre-Aranaz, F. and Sannino, G. and Grünewald, T.G.P.
Nature Communications 11 (1): 2423. 15 May 2020

GAMIBHEAR: whole-genome haplotype reconstruction from genome architecture mapping data.
Markowski, J. and Kempfer, R. and Kukalev, A. and Irastorza-Azcarate, I. and Loof, G. and Pombo, A. and Schwarz, R.F.
bioRxiv : 2020.01.30.927061. 31 January 2020

AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I. and Roux, P.F. and de Freitas, J.A.N.L.F. and Robinson, L. and Doré, G. and Sun, B. and Belenki, D. and Milanovic, M. and Herbig, U. and Schmitt, C.A. and Gil, J. and Bischof, O.
Nature Cell Biology 22 (7): 842-855. July 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in wildtype and cloche/npas4l mutant zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Kempfer, R. and Mattonet, K. and Hirsekorn, A. and Bilić, I. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
bioRxiv : 2020.06.26.173377. 26 June 2020

Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L. and Höpken, U.E. and Rehm, A.
Frontiers in Immunology 11 : 591741. 3 December 2020

Peptide-based interaction proteomics.
Meyer, K. and Selbach, M.
Molecular & Cellular Proteomics 19 (7): 1070-1075. July 2020

Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).
Meyer, T. and Jahn, N. and Lindner, S. and Röhner, L. and Dolnik, A. and Weber, D. and Scheffold, A. and Köpff, S. and Paschka, P. and Gaidzik, V.I. and Heckl, D. and Wiese, S. and Ebert, B.L. and Döhner, H. and Bullinger, L. and Döhner, K. and Krönke, J.
Leukemia 34 (2): 404-415. February 2020

Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Mikuda, N. and Schmidt-Ullrich, R. and Kärgel, E. and Golusda, L. and Wolf, J. and Höpken, U.E. and Scheidereit, C. and Kühl, A.A. and Kolesnichenko, M.
Journal of Pathology 251 (2): 160-174. June 2020

ABVD vs BEACOPP escalated in advanced-stage Hodgkin's lymphoma: Results from a multicenter European study.
Mondello, P. and Musolino, C. and Dogliotti, I. and Bohn, J.P. and Cavallo, F. and Ferrero, S. and Botto, B. and Cerchione, C. and Nappi, D. and De Lorenzo, S. and Martinelli, G. and Wolf, D. and Schmitt, C. and Loseto, G. and Cuzzocrea, S. and Willenbacher, W. and Mian, M. and Straus, D.J.
American Journal of Hematology 95 (9): 1030-1037. September 2020

Accelerating drug development for neuroblastoma: summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.
Moreno, L. and Barone, G. and DuBois, S.G. and Molenaar, J. and Fischer, M. and Schulte, J. and Eggert, A. and Schleiermacher, G. and Speleman, F. and Chesler, L. and Geoerger, B. and Hogarty, M.D. and Irwin, M.S. and Bird, N. and Blanchard, G.B. and Buckland, S. and Caron, H. and Davis, S. and De Wilde, B. and Deubzer, H.E. and Dolman, E. and Eilers, M. and George, R.E. and George, S. and Jaroslav, Š. and Maris, J.M. and Marshall, L. and Merchant, M. and Mortimer, P. and Owens, C. and Philpott, A. and Poon, E. and Shay, J.W. and Tonelli, R. and Valteau-Couanet, D. and Vassal, G. and Park, J.R. and Pearson, A.D.J.
European Journal of Cancer 136 : 52-68. September 2020

Variability of an early developmental cell population underlies stochastic laterality defects.
Moreno-Ayala, R. and Olivares-Chauvet, P. and Schäfer, R. and Junker, J.P.
bioRxiv : 2020.07.20.212282. 20 July 2020

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis.
Moreno-Layseca, P. and Jäntti, N.Z. and Godbole, R. and Sommer, C. and Jacquemet, G. and Al-Akhrass, H. and Kronqvist, P. and Kallionpää, R.E. and Oliveira-Ferrer, L. and Cervero, P. and Linder, S. and Aepfelbacher, M. and Rae, J. and Parton, R.G. and Disanza, A. and Scita, G. and Mayor, S. and Selbach, M. and Veltel, S. and Ivaska, J.
bioRxiv : 2020.10.05.323295. 5 October 2020

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y. and Heynen, G.J.J.E. and López-Alberca, M.P. and Paul, J. and Miksche, S. and Radetzki, S. and Schaller, D. and Shanina, E. and Seyffarth, C. and Kolomeets, Y. and Ziebart, N. and de Schryver, J. and Oestreich, S. and Neuenschwander, M. and Roske, Y. and Heinemann, U. and Rademacher, C. and Volkamer, A. and von Kries, J.P. and Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63 (23): 14780-14804. 10 December 2020

A quantitative modular modeling approach reveals the effects of different A20 feedback implementations for the NF-κB signaling dynamics.
Mothes, J. and Ipenberg, I. and Arslan, S.Ç. and Benary, U. and Scheidereit, C. and Wolf, J.
Frontiers in Physiology 11 : 896. 28 July 2020

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells.
Muus, C. and Luecken, M.D. and Eraslan, G. and Waghray, A. and Heimberg, G. and Sikkema, L. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smilie, C. and Jagadeesh, K. and Thu Duong, E. and Fiskin, E. and Torlai Triglia, E. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, A.Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Deprez, M. and Fischer, D.S. and Gillich, A. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Jaiswal, A. and Jiang, P. and Kapellos, T. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Lu, J. and Ludwig, L.S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Marquette, C.H. and Mbano, I. and McAdams, A.M. and Metzger, R.J. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N. and Sountoulidis, A. and Strunz, M. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
bioRxiv : 2020.04.19.049254. 21 April 2020

Single-cell analysis based dissection of clonality in myelofibrosis.
Mylonas, E. and Yoshida, K. and Frick, M. and Hoyer, K. and Christen, F. and Kaeda, J. and Obenaus, M. and Noerenberg, D. and Hennch, C. and Chan, W. and Ochi, Y. and Shiraishi, Y. and Shiozawa, Y. and Zenz, T. and Oakes, C.C. and Sawitzki, B. and Schwarz, M. and Bullinger, L. and le Coutre, P. and Rose-Zerilli, M.J.J. and Ogawa, S. and Damm, F.
Nature Communications 11 (1): 73. 7 January 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Höfler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
bioRxiv : 2020.12.18.423524. 19 December 2020

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.
Oevermann, L. and Zimmermann, C. and Voigt, S. and Künkele, A. and Lobitz, S. and Eggert, A. and Schulte, J.H. and Kaufer, B.B. and Deubzer, H.E.
Bone Marrow Transplantation 55 (1): 260-264. January 2020

Inclusion of temporal information in single cell transcriptomics.
Olivares-Chauvet, P. and Junker, J.P.
International Journal of Biochemistry and Cell Biology 122 : 105745. May 2020

Towards a more reliable identification of isomeric metabolites using pattern guided retention validation.
Opialla, T. and Kempa, S. and Pietzke, M.
Metabolites 10 (11): 457. 12 November 2020

High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma.
Orth, M.F. and Hölting, T.L.B. and Dallmayer, M. and Wehweck, F.S. and Paul, T. and Musa, J. and Baldauf, M.C. and Surdez, D. and Delattre, O. and Knott, M.M.L. and Romero-Pérez, L. and Kasan, M. and Cidre-Aranaz, F. and Gerke, J.S. and Ohmura, S. and Li, J. and Marchetto, A. and Henssen, A.G. and Özen, Ö. and Sugita, S. and Hasegawa, T. and Kanaseki, T. and Bertram, S. and Dirksen, U. and Hartmann, W. and Kirchner, T. and Grünewald, T.G.P.
Cancers 12 (3): 644. 10 March 2020

Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction.
Peitz, C. and Sprüssel, A. and Linke, R.B. and Astrahantseff, K. and Grimaldi, M. and Schmelz, K. and Toedling, J. and Schulte, J.H. and Fischer, M. and Messerschmidt, C. and Beule, D. and Keilholz, U. and Eggert, A. and Deubzer, H.E. and Lodrini, M.
Journal of Molecular Diagnostics 22 (11): 1309-1323. November 2020

Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin.
Piontek, A. and Eichner, M. and Zwanziger, D. and Beier, L.S. and Protze, J. and Walther, W. and Theurer, S. and Schmid, K.W. and Führer-Sakel, D. and Piontek, J. and Krause, G.
Molecular Oncology 14 (2): 261-276. February 2020

Using gradient boosting with stability selection on health insurance claims data to identify disease trajectories in chronic obstructive pulmonary disease.
Ploner, T. and Heß, S. and Grum, M. and Drewe-Boss, P. and Walker, J.
Statistical Methods in Medical Research 29 (12): 3684-3694. 1 December 2020

Recurrent inversion toggling and great ape genome evolution.
Porubsky, D. and Sanders, A.D. and Höps, W. and Hsieh, P. and Sulovari, A. and Li, R. and Mercuri, L. and Sorensen, M. and Murali, S.C. and Gordon, D. and Cantsilieris, S. and Pollen, A.A. and Ventura, M. and Antonacci, F. and Marschall, T. and Korbel, J.O. and Eichler, E.E.
Nature Genetics 52 (8): 849-858. August 2020

breakpointR: an R/Bioconductor package to localize strand state changes in Strand-seq data.
Porubsky, D. and Sanders, A.D. and Taudt, A. and Colomé-Tatché, M. and Lansdorp, P.M. and Guryev, V.
Bioinformatics 36 (4): 1260-1261. 15 February 2020

First-line treatment with R-CHOP or rituximab-bendamustine in patients with follicular lymphoma grade 3A - results of a retrospective analysis.
Pouyiourou, M. and Meyer, A. and Stroux, A. and Viardot, A. and La Rosée, P. and Maschmeyer, G. and Kämpfe, D. and Kahl, C. and Vucinic, V. and Monecke, A. and Hirt, C. and Weber, T. and Meissner, J. and Witzens-Harig, M. and Böttcher, S. and Schmalenberg, H. and Marks, R. and Prange-Krex, G. and Kroschinsky, F. and Hauf, E. and Keller, U. and Koch, K. and Klapper, W. and Herold, M. and Scholz, C.W.
Annals of Hematology 99 (12): 2821-2829. December 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression.
Pötzsch, M. and Berg, E. and Hummel, M. and Stein, U. and von Winterfeld, M. and Jöhrens, K. and Rau, B. and Daum, S. and Treese, C.
OncoImmunology 9 (1): 1824632. 30 September 2020

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer.
Quinn, H. and Koren, E. and Vogel, R. and Popp, O. and Mertins, P. and Messerschmidt, C. and Marangoni, E. and Fuchs, Y. and Birchmeier, W.
bioRxiv : 2020.06.05.115881. 6 June 2020

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S. and Klimmeck, D. and Falcone, M. and Demir, A. and Pouya, A. and Zeisberger, P. and Lutz, C. and Tinelli, M. and Bischel, O. and Bullinger, L. and Thiede, C. and Flörcken, A. and Westermann, J. and Ehninger, G. and Ho, A.D. and Müller-Tidow, C. and Gu, Z. and Herrmann, C. and Krijgsveld, J. and Trumpp, A. and Hansson, J.
Blood 136 (13): 1507-1519. 24 September 2020

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part phase Ib/II study.
Rambaldi, A. and Iurlo, A. and Vannucchi, A.M. and Noble, R. and von Bubnoff, N. and Guarini, A. and Martino, B. and Pezzutto, A. and Carli, G. and De Muro, M. and Luciani, S. and McMullin, M.F. and Cambier, N. and Marolleau, J.P. and Mesa, R.A. and Tibes, R. and Pancrazzi, A. and Gesullo, F. and Bettica, P. and Manzoni, S. and Di Tollo, S.
Leukemia 34 (8): 2234-2237. August 2020

A comprehensive motifs-based interactome of the C/EBPα transcription factor.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
bioRxiv : 2020.12.28.424569. 28 December 2020

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features.
Ray, J.P. and de Boer, C.G. and Fulco, C.P. and Lareau, C.A. and Kanai, M. and Ulirsch, J.C. and Tewhey, R. and Ludwig, L.S. and Reilly, S.K. and Bergman, D.T. and Engreitz, J.M. and Issner, R. and Finucane, H.K. and Lander, E.S. and Regev, A. and Hacohen, N.
Nature Communications 11 (1): 1237. 6 March 2020

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M. and Haas, S.A. and Franchini, P. and Xiong, P. and Simakov, O. and Kuhl, H. and Schöpflin, R. and Heller, D. and Moeinzadeh, M.H. and Heinrich, V. and Krannich, T. and Bressin, A. and Hartmann, M.F. and Wudy, S.A. and Dechmann, D.K.N. and Hurtado, A. and Barrionuevo, F.J. and Schindler, M. and Harabula, I. and Osterwalder, M. and Hiller, M. and Wittler, L. and Visel, A. and Timmermann, B. and Meyer, A. and Vingron, M. and Jiménez, R. and Mundlos, S. and Lupiáñez, D.G.
Science 370 (6513): 208-214. 9 October 2020

Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.
Reddington, J.P. and Garfield, D.A. and Sigalova, O.M. and Karabacak Calviello, A. and Marco-Ferreres, R. and Girardot, C. and Viales, R.R. and Degner, J.F. and Ohler, U. and Furlong, E.E.M.
Developmental Cell 55 (5): 648-664. 7 December 2020

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S. and Bröckelmann, P.J. and Iaccarino, I. and Garcia-Marquez, M. and Borchmann, S. and Jochims, F. and Kotrova, M. and Pal, K. and Brüggemann, M. and Hartmann, E. and Sasse, S. and Kobe, C. and Mathas, S. and Soekler, M. and Keller, U. and Bormann, M. and Zimmermann, A. and Richter, J. and Fuchs, M. and von Tresckow, B. and Borchmann, P. and Schlößer, H. and von Bergwelt-Baildon, M. and Rosenwald, A. and Engert, A. and Klapper, W.
Blood 136 (25): 2851-2863. 17 December 2020

A CD205-directed antibody drug conjugate - lymphoma precision oncology or sophisticated chemotherapy?
Rieke, D.T. and Keller, U.
Haematologica 105 (11): 2504-2506. 1 November 2020

Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H. and Franz, A. and Jung, M. and Weickmann, S. and Ralla, B. and Kilic, E. and Stephan, C. and Fendler, A. and Jung, K.
Theranostics 10 (20): 9268-9279. 23 July 2020

Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological factors.
Rochow, H. and Jung, M. and Weickmann, S. and Ralla, B. and Stephan, C. and Elezkurtaj, S. and Kilic, E. and Zhao, Z. and Jung, K. and Fendler, A. and Franz, A.
International Journal of Molecular Sciences 21 (21): E7812. 22 October 2020

Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y. and Gilboa, T. and van Kooten, X.F. and Kobelt, D. and Huttner, D. and Stein, U. and Meller, A.
ACS Nano 14 (10): 13964-13974. 27 October 2020

Mapping the transglycosylation relevant sites of cold-adapted β-d-galactosidase from arthrobacter sp. 32cB.
Rutkiewicz, M. and Wanarska, M. and Bujacz, A.
International Journal of Molecular Sciences 21 (15): 5354. 28 July 2020

Editorial: Modulation of human immune parameters by anticancer therapies.
Sack, U. and Tarnok, A. and Preijers, F. and Köhl, U. and Na, I.K.
Frontiers in Immunology 11 : 621556. 2 December 2020

Subnanometer-resolution structure determination in situ by hybrid subtomogram averaging - single particle cryo-EM.
Sanchez, R.M. and Zhang, Y. and Chen, W. and Dietrich, L. and Kudryashev, M.
Nature Communications 11 (1): 3709. 24 July 2020

Single-cell analysis of structural variations and complex rearrangements with tri-channel processing.
Sanders, A.D. and Meiers, S. and Ghareghani, M. and Porubsky, D. and Jeong, H. and van Vliet, M.A.C.C. and Rausch, T. and Richter-Pechańska, P. and Kunz, J.B. and Jenni, S. and Bolognini, D. and Longo, G.M.C. and Raeder, B. and Kinanen, V. and Zimmermann, J. and Benes, V. and Schrappe, M. and Mardin, B.R. and Kulozik, A.E. and Bornhauser, B. and Bourquin, J.P. and Marschall, T. and Korbel, J.O.
Nature Biotechnology 38 (3): 343-354. March 2020

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Scheer, M. and Blank, B. and Bauer, S. and Vokuhl, C. and Stegmaier, S. and Feuchtgruber, S. and Henssen, A. and Sparber-Sauer, M. and Eggert, A. and Handgretinger, R. and Pekrun, A. and Rossig, C. and Rutkowski, S. and Schlegel, P.G. and Schrappe, M. and Simon, T. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Jahnukainen, K. and Fuchs, J. and Bielack, S.S. and Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 146 (4): 953-960. April 2020

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K. and Kase, J. and Dörr, J.R. and Trescher, S. and Bhattacharya, A. and Yu, Y. and Wailes, E.M. and Fan, D.N.Y. and Lohneis, P. and Milanovic, M. and Lau, A. and Lenze, D. and Hummel, M. and Chapuy, B. and Leser, U. and Reimann, M. and Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS.
Schmidt, K. and Sack, U. and Graf, R. and Winkler, W. and Popp, O. and Mertins, P. and Sommermann, T. and Kocks, C. and Rajewsky, K.
Frontiers in Immunology 11 : 602868. 1 December 2020

ASH highlights 2019: "aggressive B-cell lymphoma".
Schmitt, C.A.
memo: Magazine of European Medical Oncology 13 (3): 266-269. 20 May 2020

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D. and Formichetti, S. and Junker, J.P. and Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16 (11): e9946. 1 November 2020

Spatio-temporal bone remodeling after hematopoietic stem cell transplantation.
Schwarz, C.S. and Bucher, C.H. and Schlundt, C. and Mertlitz, S. and Riesner, K. and Kalupa, M. and Verlaat, L. and Schmidt-Bleek, O. and Sass, R.A. and Schmidt-Bleek, K. and Duda, G.N. and Penack, O. and Na, I.K.
International Journal of Molecular Sciences 22 (1): 267. 29 December 2020

A single cell Arabidopsis root atlas reveals developmental trajectories in wild type and cell identity mutants.
Shahan, R. and Hsu, C.W. and Nolan, T.M. and Cole, B.J. and Taylor, I.W. and Vlot, A.H.C. and Benfey, P.N. and Ohler, U.
bioRxiv : 2020.06.29.178863. 30 June 2020

The effects of common structural variants on 3D chromatin structure.
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BMC Genomics 21 (1): 95. 30 January 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

Human endogenous retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. and Cai, H. and Bunse, M. and Feschotte, C. and Izsvak, Z.
bioRxiv : 2020.05.27.120170. 2 June 2020

Bacteriophages: emerging applications in medicine, food, and biotechnology.
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PHAGE 1 (2): 75-82. 16 June 2020

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T. and Yasuda, T. and Ronen, J. and Wirtz, T. and Weber, T. and Sack, U. and Caeser, R. and Zhang, J. and Li, X. and Chu, V.T. and Jauch, A. and Unger, K. and Hodson, D.J. and Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117 (25): 14421-14432. 23 June 2020

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.
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Nature Communications 11 (1): 2861. 5 June 2020

HCoV- and SARS-CoV-2 cross-reactive T cells in CVID patients.
Steiner, S. and Sotzny, F. and Bauer, S. and Na, I.K. and Schmueck-Henneresse, M. and Corman, V.M. and Schwarz, T. and Drosten, C. and Wendering, D.J. and Behrends, U. and Volk, H.D. and Scheibenbogen, C. and Hanitsch, L.G.
Frontiers in Immunology 11 : 607918. 23 December 2020

Combination therapy with Olaratumab/doxorubicin in advanced or metastatic soft tissue sarcoma -a single-Centre experience.
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BMC Cancer 20 (1): 68. 29 January 2020

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
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PLoS Genetics 16 (12): e1009190. 28 December 2020

Towards a deeper annotation of human lncRNAs.
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Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1863 (4): 194385. April 2020

Keeping the proportions of protein complex components in check.
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Cell Systems 10 (2): 125-132. 26 February 2020

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.
Tausch, E. and Beck, P. and Schlenk, R.F. and Jebaraj, B.M.C. and Dolnik, A. and Yosifov, D.Y. and Hillmen, P. and Offner, F. and Janssens, A. and Babu, K.G. and Grosicki, S. and Mayer, J. and Panagiotidis, P. and McKeown, A. and Gupta, I.V. and Skorupa, A. and Pallaud, C. and Bullinger, L. and Mertens, D. and Döhner, H. and Stilgenbauer, S.
Haematologica 105 (10): 2440-2447. October 2020

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.
Tausch, E. and Schneider, C. and Robrecht, S. and Zhang, C. and Dolnik, A. and Bloehdorn, J. and Bahlo, J. and Al-Sawaf, O. and Ritgen, M. and Fink, A.M. and Eichhorst, B. and Kreuzer, K.A. and Tandon, M. and Humphrey, K. and Jiang, Y. and Schary, W. and Bullinger, L. and Mertens, D. and Lurà, M.P. and Kneba, M. and Döhner, H. and Fischer, K. and Hallek, M. and Stilgenbauer, S.
Blood 135 (26): 2402-2412. 25 June 2020

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.
Textoris-Taube, K. and Cammann, C. and Henklein, P. and Topfstedt, E. and Ebstein, F. and Henze, S. and Liepe, J. and Zhao, F. and Schadendorf, D. and Dahlmann, B. and Uckert, W. and Paschen, A. and Mishto, M. and Seifert, U.
European Journal of Immunology 50 (2): 270-283. February 2020

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M. and Toedling, J. and Sprüssel, A. and Pfeil, S. and Savelyeva, L. and Capper, D. and Messerschmidt, C. and Beule, D. and Groeneveld-Krentz, S. and Eckert, C. and Gambara, G. and Henssen, A.G. and Finkler, S. and Schulte, J.H. and Sieber, A. and Bluethgen, N. and Regenbrecht, C.R.A. and Künkele, A. and Lodrini, M. and Eggert, A. and Deubzer, H.E.
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

Phosphosite analysis of the cytomegaloviral mRNA export factor pUL69 reveals serines with critical importance for recruitment of cellular proteins Pin1 and UAP56/URH49.
Thomas, M. and Müller, R. and Horn, G. and Bogdanow, B. and Imami, K. and Milbradt, J. and Steingruber, M. and Marschall, M. and Schilling, E.M. and Fossen, T. and Stamminger, T.
Journal of Virology 94 (8): e02151-19. 31 March 2020

Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors.
Timme, N. and Han, Y. and Liu, S. and Yosief, H.O. and García, H.D. and Bei, Y. and Klironomos, F. and MacArthur, I.C. and Szymansky, A. and von Stebut, J. and Bardinet, V. and Dohna, C. and Künkele, A. and Rolff, J. and Hundsdörfer, P. and Lissat, A. and Seifert, G. and Eggert, A. and Schulte, J.H. and Zhang, W. and Henssen, A.G.
Translational Oncology 13 (2): 221-232. February 2020

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma.
Tjaden, B. and Baum, K. and Marquardt, V. and Simon, M. and Trajkovic-Arsic, M. and Kouril, T. and Siebers, B. and Lisec, J. and Siveke, J.T. and Schulte, J.H. and Benary, U. and Remke, M. and Wolf, J. and Schramm, A.
Scientific Reports 10 (1): 7157. 28 April 2020

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
Toboso-Navasa, A. and Gunawan, A. and Morlino, G. and Nakagawa, R. and Taddei, A. and Damry, D. and Patel, Y. and Chakravarty, P. and Janz, M. and Kassiotis, G. and Brink, R. and Eilers, M. and Calado, D.P.
Journal of Experimental Medicine 217 (7): e20191933. 6 July 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
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Molecular Carcinogenesis 59 (7): 724-273. July 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T. and Graf, R. and Wulf-Goldenberg, A. and Stecklum, M. and Strauß, G. and Kühn, R. and Kocks, C. and Rajewsky, K. and Chu, V.T.
Molecular Therapy 28 (12): 2621-2634. 2 December 2020

Protocol for efficient CRISPR/Cas9/AAV-mediated homologous recombination in mouse hematopoietic stem and progenitor cells.
Tran, N.T. and Trombke, J. and Rajewsky, K. and Chu, V.T.
STAR Protocols 1 (1): 100028. 19 June 2020

R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48 (18): e105. 9 October 2020

Therapeutic targeting of preleukemia cells in a mouse model of mutant acute myeloid leukemia.
Uckelmann, H.J. and Kim, S.M. and Wong, E.M. and Hatton, C. and Giovinazzo, H. and Gadrey, J.Y. and Krivtsov, A.V. and Rücker, F.G. and Döhner, K. and McGeehan, G.M. and Levine, R.L. and Bullinger, L. and Vassiliou, G.S. and Armstrong, S.A.
Science 367 (6477): 586-590. 31 January 2020

covRNA: discovering covariate associations in large-scale gene expression data.
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BMC Research Notes 13 (1): 92. 24 February 2020

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review.
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SEMITONES: Single-cEll Marker IdentificaTiON by Enrichment Scoring.
Vlot, A.H.C. and Maghsudi, S. and Ohler, U.
bioRxiv : 2020.11.17.386664. 18 November 2020

Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads.
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Purifying selection against pathogenic mitochondrial DNA in human T cells.
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New England Journal of Medicine 383 (16): 1556-1563. 15 October 2020

In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe(2) and NHC*-Au-S-GLUC against advanced prostate cancer PC3.
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Anti-Cancer Drugs 31 (7): 672-683. August 2020

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility.
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Science 370 (6523): eabc6617. 18 December 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K. and Lim, E.L. and Petkovic, M. and Elizalde, S. and Birkbak, N.J. and Wilson, G.A. and Moore, D.A. and Grönroos, E. and Rowan, A. and Dewhurst, S.M. and Demeulemeester, J. and Dentro, S.C. and Horswell, S. and Au, L. and Haase, K. and Escudero, M. and Rosenthal, R. and Bakir, M.A. and Xu, H. and Litchfield, K. and Lu, W.T. and Mourikis, T.P. and Dietzen, M. and Spain, L. and Cresswell, G.D. and Biswas, D. and Lamy, P. and Nordentoft, I. and Harbst, K. and Castro-Giner, F. and Yates, L.R. and Caramia, F. and Jaulin, F. and Vicier, C. and Tomlinson, I.P.M. and Brastianos, P.K. and Cho, R.J. and Bastian, B.C. and Dyrskjøt, L. and Jönsson, G.B. and Savas, P. and Loi, S. and Campbell, P.J. and Andre, F. and Luscombe, N.M. and Steeghs, N. and Tjan-Heijnen, V.C.G. and Szallasi, Z. and Turajlic, S. and Jamal-Hanjani, M. and Van Loo, P. and Bakhoum, S.F. and Schwarz, R.F. and McGranahan, N. and Swanton, C.
Nature 587 (7832): 126-132. 5 November 2020

PEDL: extracting protein-protein associations using deep language models and distant supervision.
Weber, L. and Thobe, K. and Migueles Lozano, O.A. and Wolf, J. and Leser, U.
Bioinformatics 36 (Suppl 1): i490-i498. July 2020

4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay.
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Cell Reports 33 (2): 108262. 13 October 2020

Integrative functional genomics decodes herpes simplex virus 1.
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Nature Communications 11 (1): 2038. 27 April 2020

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system.
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bioRxiv : 2020.08.06.240176. 6 August 2020

Ubiquitination and ubiquitin-like modifications in multiple myeloma: biology and therapy.
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Cancers 12 (12): 3764. 14 December 2020

Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.
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Annals of Translational Medicine 8 (8): 568. April 2020

Wegbereiter der modernen Krebsforschung: Theodor Boveri und Otto Warburg [Pioneers of modern cancer research: Theodor Boveri and Otto Warburg].
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BIOspektrum 26 (3): 343-344. May 2020

Clinical outcome in patients with carcinoma of the esophagogastric junction treated with neoadjuvant radiochemotherapy or perioperative chemotherapy: a two-enter retrospective analysis.
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Oncology 98 (10): 706-713. October 2020

Non-thermal effects of radiofrequency electromagnetic fields.
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Scientific Reports 10 (1): 13488. 10 August 2020

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention.
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bioRxiv : 2020.05.05.079194. 5 May 2020

hGBP1 coordinates chlamydia restriction and inflammasome activation through sequential GTP hydrolysis.
Xavier, A. and Al-Zeer, M.A. and Meyer, T.F. and Daumke, O.
Cell Reports 31 (7): 107667. 19 May 2020

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
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bioRxiv : 2020.02.04.934927. 11 February 2020

Overactivation of the NF-κB pathway impairs molar enamel formation.
Yamada, A. and Kawasaki, M. and Miake, Y. and Yamada, Y. and Blackburn, J. and Kawasaki, K. and Trakanant, S. and Nagai, T. and Nihara, J. and Kudo, T. and Meguro, F. and Schmidt-Ullrich, R. and Liu, B. and Hu, Y. and Page, A. and Ramírez, Á. and Sharpe, P.T. and Maeda, T. and Takagi, R. and Ohazama, A.
Oral Diseases 26 (7): 1513-1522. October 2020

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
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Blood 136 (11): 1303-1316. 10 September 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L. and Klaus, A. and Maas, J. and Morin-Poulard, I. and Weijts, B. and Schulte-Merker, S. and Berezikov, E. and Junker, J.P. and Robin, C.
Blood 136 (7): 831-844. 13 August 2020

Monogenic variants in dystonia: an exome-wide sequencing study.
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Lancet Neurology 19 (11): 908-918. November 2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202 (10): 1445-1457. 15 November 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
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Nature Communications 11 (1): 736. 5 February 2020

Sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma.
Zirngibl, F. and Flemmig, C. and Lang, P. and Künkele, A. and Eggert, A. and Schulte, J.H. and Deubzer, H.E.
Children 7 (11): 198. November 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
bioRxiv : 2020.01.23.916627. 24 January 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
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Cell Reports 33 (13): 108533. 29 December 2020

Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development.
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Thrombosis and Haemostasis 120 (2): 344-347. February 2020

2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.
Abdulhay, N.J. and Fiorini, C. and Verboon, J.M. and Ludwig, L.S. and Ulirsch, J.C. and Zieger, B. and Lareau, C.A. and Mi, X. and Roy, A. and Obeng, E.A. and Erlacher, M. and Gupta, N. and Gabriel, S.B. and Ebert, B.L. and Niemeyer, C.M. and Khoriaty, R.N. and Ancliff, P. and Gazda, H.T. and Wlodarski, M.W. and Sankaran, V.G.
Journal of Experimental Medicine 216 (5): 1050-1060. 6 May 2019

C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice.
Ackermann, T. and Hartleben, G. and Müller, C. and Mastrobuoni, G. and Groth, M. and Sterken, B.A. and Zaini, M.A. and Youssef, S.A. and Zuidhof, H.R. and Krauss, S.R. and Kortman, G. and de Haan, G. and de Bruin, A. and Wang, Z.Q. and Platzer, M. and Kempa, S. and Calkhoven, C.F.
Communications Biology 2 : 208. 14 June 2019

Pressurized intraperitoneal aerosol chemotherapy and its effect on gastric-cancer-derived peritoneal metastases: an overview.
Alberto, M. and Brandl, A. and Garg, P.K. and Gül-Klein, S. and Dahlmann, M. and Stein, U. and Rau, B.
Clinical and Experimental Metastasis 36 (1): 1-14. February 2019

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.
Andersch, L. and Radke, J. and Klaus, A. and Schwiebert, S. and Winkler, A. and Schumann, E. and Grunewald, L. and Zirngibl, F. and Flemmig, C. and Jensen, M.C. and Rossig, C. and Joussen, A. and Henssen, A. and Eggert, A. and Schulte, J.H. and Künkele, A.
BMC Cancer 19 (1): 895. 9 September 2019

Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry.
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Pathology Research and Practice 215 (11): 152662. November 2019

Saffron: The golden spice with therapeutic properties on digestive diseases.
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Nutrients 11 (5): 943. 26 April 2019

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
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bioRxiv : 826370. 17 December 2019

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
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bioRxiv : 840132. 13 November 2019

Common mode of remodeling AAA ATPases p97/CDC48 by their disassembling cofactors ASPL/PUX1.
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In contrast to Western diet, a plant-based, high-fat, low-sugar diet does not exacerbate retinal endothelial injury in streptozotocin-induced diabetes.
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FASEB Journal 33 (9): 10327-10338. September 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
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Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models.
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Of gene expression and cell division time: a mathematical framework for advanced differential gene expression and data analysis.
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Cell Systems 9 (6): 569-579. 18 December 2019

Controlling nuclear NF-κB dynamics by β-TrCP-insights from a computational model.
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Biomedicines 7 (2): 40. 27 May 2019

Modelling the DNA topology: the effect of the loop bending on G-quadruplex stability.
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Journal of Statistical Mechanics: Theory and Experiment 2019 (9): 094004. 2 September 2019

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.
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Nature Communications 10 (1): 2370. 30 May 2019

A resource of targeted mutant mouse lines for 5,061 genes.
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bioRxiv : 844092. 22 November 2019

A clonal expression biomarker associates with lung cancer mortality.
Biswas, D. and Birkbak, N.J. and Rosenthal, R. and Hiley, C.T. and Lim, E.L. and Papp, K. and Boeing, S. and Krzystanek, M. and Djureinovic, D. and La Fleur, L. and Greco, M. and Döme, B. and Fillinger, J. and Brunnström, H. and Wu, Y. and Moore, D.A. and Skrzypski, M. and Abbosh, C. and Litchfield, K. and Al Bakir, M. and Watkins, T.B.K. and Veeriah, S. and Wilson, G.A. and Jamal-Hanjani, M. and Moldvay, J. and Botling, J. and Chinnaiyan, A.M. and Micke, P. and Hackshaw, A. and Bartek, J. and Csabai, I. and Szallasi, Z. and Herrero, J. and McGranahan, N. and Swanton, C.
Nature Medicine 25 (10): 1540-1548. October 2019

Identification and ranking of recurrent neo-epitopes in cancer.
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BMC Medical Genomics 12 : 171. 27 November 2019

Identification and regulation of the long non-coding RNA Heat2 in heart failure.
Boeckel, J.N. and Perret, M.F. and Glaser, S.F. and Seeger, T. and Heumüller, A.W. and Chen, W. and John, D. and Kokot, K.E. and Katus, H.A. and Haas, J. and Lackner, M.K. and Kayvanpour, E. and Grabe, N. and Dieterich, C. and von Haehling, S. and Ebner, N. and Hünecke, S. and Leuschner, F. and Fichtlscherer, S. and Meder, B. and Zeiher, A.M. and Dimmeler, S. and Keller, T.
Journal of Molecular and Cellular Cardiology 126 : 13-22. January 2019

The anti-amyloid compound DO1 decreases plaque pathology and neuroinflammation-related expression changes in 5xFAD transgenic mice.
Boeddrich, A. and Babila, J.T. and Wiglenda, T. and Diez, L. and Jacob, M. and Nietfeld, W. and Huska, M.R. and Haenig, C. and Groenke, N. and Buntru, A. and Blanc, E. and Meier, J.C. and Vannoni, E. and Erck, C. and Friedrich, B. and Martens, H. and Neuendorf, N. and Schnoegl, S. and Wolfer, D.P. and Loos, M. and Beule, D. and Andrade-Navarro, M.A. and Wanker, E.E.
Cell Chemical Biology 26 (1): 109-120. 17 January 2019

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B. and Schmidt, M. and Weisbach, H. and Gruska, I. and Vetter, B. and Imami, K. and Ostermann, E. and Brune, W. and Selbach, M. and Hagemeier, C. and Wiebusch, L.
bioRxiv : 856435. 26 November 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Wang, X. and Eichelbaum, K. and Sadewasser, A. and Husic, I. and Paki, K. and Budt, M. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
Borgsmüller, N. and Gloaguen, Y. and Opialla, T. and Blanc, E. and Sicard, E. and Royer, A.L. and Le Bizec, B. and Durand, S. and Migné, C. and Pétéra, M. and Pujos-Guillot, E. and Giacomoni, F. and Guitton, Y. and Beule, D. and Kirwan, J.
Metabolites 9 (9): 171. 21 August 2019

WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
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bioRxiv : 713925. 24 July 2019

Crowdfunded whole-genome sequencing of the celebrity cat Lil BUB identifies causal mutations for her osteopetrosis and polydactyly.
Bridavsky, M. and Kuhl, H. and Woodruf, A. and Kornak, U. and Timmermann, B. and Mages, N. and Lupiáñez, D.G. and Symmons, O. and Ibrahim, D.M.
bioRxiv : 556761. 22 February 2019

Time-resolved DNA release from an O-antigen specific Salmonella bacteriophage with a contractile tail.
Broeker, N.K. and Roske, Y. and Valleriani, A. and Stephan, M.S. and Andres, D. and Koetz, J. and Heinemann, U. and Barbirz, S.
Journal of Biological Chemistry 294 (31): 11751-11761. 2 August 2019

Isolation and long-term cultivation of mouse alveolar macrophages.
Busch, C. J.-L. and Favret, J. and Geirsdóttir, L. and Molawi, K. and Sieweke, M.H.
Bio-protocol 9 (14) 20 July 2019

SaTAnn quantifies translation on the functionally heterogeneous transcriptome.
Calviello, L. and Hirsekorn, A. and Ohler, U.
bioRxiv : 608794. 14 April 2019

Ribo-seQC: comprehensive analysis of cytoplasmic and organellar ribosome profiling data.
Calviello, L. and Sydow, D. and Harnett, D. and Ohler, U.
bioRxiv : 601468. 8 April 2019

DDX3 depletion selectively represses translation of structured mRNAs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
bioRxiv : 589218. 26 March 2019

Multi-platform discovery of haplotype-resolved structural variation in human genomes.
Chaisson, M.J.P. and Sanders, A.D. and Zhao, X. and Malhotra, A. and Porubsky, D. and Rausch, T. and Gardner, E.J. and Rodriguez, O.L. and Guo, L. and Collins, R.L. and Fan, X. and Wen, J. and Handsaker, R.E. and Fairley, S. and Kronenberg, Z.N. and Kong, X. and Hormozdiari, F. and Lee, D. and Wenger, A.M. and Hastie, A.R. and Antaki, D. and Anantharaman, T. and Audano, P.A. and Brand, H. and Cantsilieris, S. and Cao, H. and Cerveira, E. and Chen, C. and Chen, X. and Chin, C.S. and Chong, Z. and Chuang, N.T. and Lambert, C.C. and Church, D.M. and Clarke, L. and Farrell, A. and Flores, J. and Galeev, T. and Gorkin, D.U. and Gujral, M. and Guryev, V. and Heaton, W.H. and Korlach, J. and Kumar, S. and Kwon, J.Y. and Lam, E.T. and Lee, J.E. and Lee, J. and Lee, W.P. and Lee, S.P. and Li, S. and Marks, P. and Viaud-Martinez, K. and Meiers, S. and Munson, K.M. and Navarro, F.C.P. and Nelson, B.J. and Nodzak, C. and Noor, A. and Kyriazopoulou-Panagiotopoulou, S. and Pang, A.W.C. and Qiu, Y. and Rosanio, G. and Ryan, M. and Stütz, A. and Spierings, D.C.J. and Ward, A. and Welch, A.E. and Xiao, M. and Xu, W. and Zhang, C. and Zhu, Q. and Zheng-Bradley, X. and Lowy, E. and Yakneen, S. and McCarroll, S. and Jun, G. and Ding, L. and Koh, C.L. and Ren, B. and Flicek, P. and Chen, K. and Gerstein, M.B. and Kwok, P.Y. and Lansdorp, P.M. and Marth, G.T. and Sebat, J. and Shi, X. and Bashir, A. and Ye, K. and Devine, S.E. and Talkowski, M.E. and Mills, R.E. and Marschall, T. and Korbel, J.O. and Eichler, E.E. and Lee, C.
Nature Communications 10 (1): 1784. 16 April 2019

Comparing agent‐based delivery of DNA and PNA forced intercalation (FIT) probes for multicolor mRNA imaging.
Chamiolo, J. and Fang, G.M. and Hövelmann, F. and Friedrich, D. and Knoll, A. and Loewer, A. and Seitz, O.
ChemBioChem 20 (4): 595-604. 15 February 2019

Molecular recording of mammalian embryogenesis.
Chan, M.M. and Smith, Z.D. and Grosswendt, S. and Kretzmer, H. and Norman, T.M. and Adamson, B. and Jost, M. and Quinn, J.J. and Yang, D. and Jones, M.G. and Khodaverdian, A. and Yosef, N. and Meissner, A. and Weissman, J.S.
Nature 570 (7759): 77-82. 6 June 2019

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
Chemi, F. and Rothwell, D.G. and McGranahan, N. and Gulati, S. and Abbosh, C. and Pearce, S.P. and Zhou, C. and Wilson, G.A. and Jamal-Hanjani, M. and Birkbak, N. and Pierce, J. and Kim, C.S. and Ferdous, S. and Burt, D.J. and Slane-Tan, D. and Gomes, F. and Moore, D. and Shah, R. and Al Bakir, M. and Hiley, C. and Veeriah, S. and Summers, Y. and Crosbie, P. and Ward, S. and Mesquita, B. and Dynowski, M. and Biswas, D. and Tugwood, J. and Blackhall, F. and Miller, C. and Hackshaw, A. and Brady, G. and Swanton, C. and Dive, C.
Nature Medicine 25 (10): 1534-1539. October 2019

Current and future treatment strategies for rhabdomyosarcoma.
Chen, C. and Dorado-Garcia, H. and Scheer, M. and Henssen, A.G.
Frontiers in Oncology 9 : 1458. 20 December 2019

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C. and Müller, M. and Pak, H.S. and Harnett, D. and Huber, F. and Grun, D. and Leleu, M. and Auger, A. and Arnaud, M. and Stevenson, B.J. and Michaux, J. and Bilic, I. and Hirsekorn, A. and Calviello, L. and Simó-Riudalbas, L. and Planet, E. and Lubiński, J. and Bryśkiewicz, M. and Wiznerowicz, M. and Xenarios, I. and Zhang, L. and Trono, D. and Harari, A. and Ohler, U. and Coukos, G. and Bassani-Sternberg, M.
bioRxiv : 758680. 6 September 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
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Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D. and Rharass, T. and Schulz, M. and Phan, M.H.Q. and Wakula, P. and Mhatre, K.N. and Plotnick, D. and Werdich, A.A. and Zauber, H. and Sury, M.D. and Selbach, M. and Heinzel, F.R. and Klussmann, E. and Panakova, D.
bioRxiv : 741637. 20 August 2019

Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in amyotrophic lateral sclerosis.
De Santis, R. and Alfano, V. and de Turris, V. and Colantoni, A. and Santini, L. and Garone, M.G. and Antonacci, G. and Peruzzi, G. and Sudria-Lopez, E. and Wyler, E. and Anink, J.J. and Aronica, E. and Landthaler, M. and Pasterkamp, R.J. and Bozzoni, I. and Rosa, A.
Cell Reports 27 (13): 3818-3831. 25 June 2019