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2021

Metastasis : methods and protocols.
Stein, U.S., ed.
Methods in Molecular Biology, 2294 . Springer / Humana Press, New York, NY. ISBN 978-1-0716-1349-8 2021

From operating table to laboratory bench: the path toward metastasis research from the clinical setting.
Alberto Vilchez, M. and Rau, B.
Methods in Molecular Biology 2294 : 325-333. 2021

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, B. and Zasada, C. and Baum, K. and Wuenschel, J. and Mastrobuoni, G. and Lodrini, M. and Astrahantseff, K. and Winkler, A. and Schulte, J.H. and Finkler, S. and Forbes, M. and Hundsdoerfer, P. and Guergen, D. and Hoffmann, J. and Wolf, J. and Eggert, A. and Kempa, S. and Deubzer, H.E.
International Journal of Cancer 148 (5): 1219-1232. 1 March 2021

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Aslam, M.A. and Alemdehy, M.F. and Kwesi-Maliepaard, E.M. and Muhaimin, F.I. and Caganova, M. and Pardieck, I.N. and van den Brand, T. and van Welsem, T. and de Rink, I. and Song, J.Y. and de Wit, E. and Arens, R. and Jacobs, H. and van Leeuwen, F.
EMBO Reports 22 (2): e51184. 3 February 2021

Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki, P. and Riesenfeld, S.J. and Hütter, J.C. and Torlai Triglia, E. and Kowalczyk, M.S. and Ricardo-Gonzalez, R.R. and Lian, M. and Amezcua Vesely, M.C. and Kroehling, L. and Xu, H. and Slyper, M. and Muus, C. and Ludwig, L.S. and Christian, E. and Tao, L. and Kedaigle, A.J. and Steach, H.R. and York, A.G. and Skadow, M.H. and Yaghoubi, P. and Dionne, D. and Jarret, A. and McGee, H.M. and Porter, C.B.M. and Licona-Limón, P. and Bailis, W. and Jackson, R. and Gagliani, N. and Gasteiger, G. and Locksley, R.M. and Regev, A. and Flavell, R.A.
Nature 592 (7852): 128-132. 1 April 2021

Cerebral EBV-positive PTLD controlled by PD-1 checkpoint blockade in a liver transplant patient.
Bittner, A. and Radke, J. and Eurich, D. and Wiener, E. and Denker, S. and Anagnostopoulos, I. and Na, I.K. and Heppner, F.L. and Bullinger, L. and Schmitt, C.A.
Leukemia & Lymphoma 22 February 2021 (In Press)

PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial.
Borchmann, P. and Plütschow, A. and Kobe, C. and Greil, R. and Meissner, J. and Topp, M.S. and Ostermann, H. and Dierlamm, J. and Mohm, J. and Thiemer, J. and Sökler, M. and Kerkhoff, A. and Ahlborn, M. and Halbsguth, T.V. and Martin, S. and Keller, U. and Balabanov, S. and Pabst, T. and Vogelhuber, M. and Hüttmann, A. and Wilhelm, M. and Zijlstra, J.M. and Moccia, A. and Kuhnert, G. and Bröckelmann, P.J. and von Tresckow, B. and Fuchs, M. and Klimm, B. and Rosenwald, A. and Eich, H. and Baues, C. and Marnitz, S. and Hallek, M. and Diehl, V. and Dietlein, M. and Engert, A.
Lancet Oncology 22 (2): 223-234. February 2021

Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo.
Briest, F. and Koziolek, E.J. and Albrecht, J. and Schmidt, F. and Bernsen, M.R. and Haeck, J. and Kühl, A.A. and Sedding, D. and Hartung, T. and Exner, S. and Welzel, M. and Fischer, C. and Grötzinger, C. and Brenner, W. and Baum, R.P. and Grabowski, P.
Neoplasia 23 (1): 80-98. January 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 : 240. 11 January 2021

Hemostatic management in an infant with neuroblastoma and severe hemophilia B with extended half-life recombinant factor IX fusion protein.
Cuntz, F. and Deubzer, H.E. and Schulte, J.H. and Nimtz-Talaska, A. and Eggert, A. and Holzhauer, S.
Journal of Pediatric Hematology Oncology 3 March 2021 (In Press)

A bioinformatic pipeline to identify biomarkers for metastasis formation from RNA sequencing data.
Dahlmann, M. and Stein, U.S.
Methods in Molecular Biology 2294 : 221-238. 2021

Early bilirubinemia after allogeneic stem cell transplantation - an endothelial complication.
Dai, H. and Penack, O. and Radujkovic, A. and Schult, D. and Majer-Lauterbach, J. and Blau, I.W. and Bullinger, L. and Jiang, S. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Bone Marrow Transplantation 30 January 2021 (In Press)

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. and Lebedin, M. and de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021

Thyrotropin receptor-specific lymphocytes in adenovirus-TSHR-immunized native and human leukocyte antigen-DR3-transgenic mice and in Graves' disease patient blood.
Degen, H. and Gavvovidis, I. and Blankenstein, T. and Uhland, K. and Ungerer, M.
Thyroid 8 February 2021 (In Press)

„Liquid biopsies“ als neue Diagnostikplattform in der pädiatrischen Onkologie [Liquid biopsies as a new diagnostic platform in pediatric oncology].
Deubzer, H.E. and Eggert, A. and Pajtler, K. W.
Onkologe 3 March 2021 (In Press)

Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M. and Aaby, P.r and Khader, S.A. and Barreiro, L.B. and Bekkering, S. and Chavakis, T. and van Crevel, R. and Curtis, N. and DiNardo, A.R. and Dominguez-Andres, J. and Duivenwoorden, R. and Fanucchi, S. and Fayad, Z. and Fuchs, E. and Hamon, M. and Jeffrey, K.L. and Khan, N. and Joosten, L.A.B. and Kaufmann, E. and Latz, E. and Matarese, G. and van der Meer, J.W.M. and Mhlanga, M. and Moorlag, S.J.C.F.M. and Mulder, W.J.M. and Naik, S. and Novakovic, B. and O'Neill, L. and Ochando, J. and Ozato, K. and Riksen, N.P. and Sauerwein, R. and Sherwood, E.R. and Schlitzer, A. and Schultze, J.L. and Sieweke, M.H. and Benn, C.S. and Stunnenberg, H. and Sun, J. and van de Veerdonk, F.L. and Weis, S. and Williams, D.L. and Xavier, R. and Netea, M.G.
Nature Immunology 22 (1): 2-6. January 2021

Mechanical forces switch blood vessel subtypes to arrest adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T. and Löhning, M.
Research Square : rs.3.rs-120475. 12 January 2021

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Ebert, P. and Audano, P. A. and Zhu, Q. and Rodriguez-Martin, B. and Porubsky, D. and Bonder, M.J. and Sulovari, A. and Ebler, J. and Zhou, W. and Serra Mari, R. and Yilmaz, F. and Zhao, X. and Hsieh, P.H. and Lee, J. and Kumar, S. and Lin, J. and Rausch, T. and Chen, Y. and Ren, J. and Santamarina, M. and Höps, W. and Ashraf, H. and Chuang, N.T. and Yang, X. and Munson, K.M. and Lewis, A.P. and Fairley, S. and Tallon, L.J. and Clarke, W.E. and Basile, A.O. and Byrska-Bishop, M. and Corvelo, A. and Evani, U.S. and Lu, T.Y. and Chaisson, M.J.P. and Chen, J. and Li, C. and Brand, H. and Wenger, A.M. and Ghareghani, M. and Harvey, W.T. and Raeder, B. and Hasenfeld, P. and Regier, A.A. and Abel, H.J. and Hall, I.M. and Flicek, P. and Stegle, O. and Gerstein, M.B and Tubio, J.M.C. and Mu, Z. and Li, Y.I. and Shi, X. and Hastie, A.R. and Ye, K. and Chong, Z. and Sanders, A.D. and Zody, M.C. and Talkowski, M.E. and Mills, R. E. and Devine, S.E. and Lee, C. and Korbel, J.O. and Marschall, T. and Eichler, E.E.
Science : eabf7117. 25 February 2021

Thymoquinone: a tie-breaker in SARS-CoV2-infected cancer patients?
Elgohary, S. and Elkhodiry, A.A. and Amin, N.S. and Stein, U. and El Tayebi, H.M.
Cells 10 (2): 302. 2 February 2021

An autochthonous mouse model of Myd88- and BCL2-driven diffuse large B-cell lymphoma reveals actionable molecular vulnerabilities.
Flümann, R. and Rehkämper, T. and Nieper, P. and Pfeiffer, P. and Holzem, A. and Klein, S. and Bhatia, S. and Kochanek, M. and Kisis, I. and Pelzer, B.W. and Ahlert, H. and Hauer, J. and da Palma Guerreiro, A. and Ryan, J.A. and Reimann, M. and Riabinska, A. and Wiederstein, J. and Krüger, M. and Deckert, M. and Altmüller, J. and Klatt, A.R. and Frenzel, L.P. and Pasqualucci, L. and Béguelin, W. and Melnick, A.M. and Sander, S. and Montesinos-Rongen, M. and Brunn, A. and Lohneis, P. and Büttner, R. and Kashkar, H. and Borkhardt, A. and Letai, A. and Persigehl, T. and Peifer, M. and Schmitt, C.A. and Reinhardt, H.C. and Knittel, G.
Blood Cancer Discovery 2 (1): 70-91. January 2021

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.
Giacopelli, B. and Wang, M. and Cleary, A. and Wu, Y.Z. and Schultz, A.R. and Schmutz, M. and Blachly, J.S. and Eisfeld, A.K. and Mundy-Bosse, B. and Vosberg, S. and Greif, P.A. and Claus, R. and Bullinger, L. and Garzon, R. and Coombes, K.R. and Bloomfield, C.D. and Druker, B.J. and Tyner, J.W. and Byrd, J.C. and Oakes, C.C.
Genome Research 11 March 2021 (In Press)

Editorial: Monocyte heterogeneity and function.
Ginhoux, F. and Mildner, A. and Gautier, E.L. and Schlitzer, A. and Jakubzick, C. and Varol, C. and Bain, C. and Guermonprez, P.
Frontiers in Immunology 11 : 626725. 7 January 2021

Genome-wide analysis of actively translated open reading frames using riboTaper/ORFquant.
Harnett, D. and Meerdink, E. and Calviello, L. and Sydow, D. and Ohler, U.
Methods in Molecular Biology 2252 : 331-346. 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A. and Sieverling, L. and Nadler-Holly, M. and Ziehm, M. and Toprak, U.H. and Herrmann, C. and Ishaque, N. and Okonechnikov, K. and Gartlgruber, M. and Park, Y.G. and Wecht, E.M. and Savelyeva, L. and Henrich, K.O. and Rosswog, C. and Fischer, M. and Hero, B. and Jones, D.T.W. and Pfaff, E. and Witt, O. and Pfister, S.M. and Volckmann, Ri. and Koster, J. and Kiesel, K. and Rippe, K. and Taschner-Mandl, S. and Ambros, P. and Brors, B. and Selbach, M. and Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M. and Eichner, R. and Stroh, J. and Morath, V. and Kuisl, A. and Zecha, J. and Lawatscheck, J. and Baek, K. and Garz, A.K. and Rudelius, M. and Deuschle, F.C. and Keller, U. and Lemeer, S. and Verbeek, M. and Götze, K.S. and Skerra, A. and Weber, W.A. and Buchner, J. and Schulman, B.A. and Kuster, B. and Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81 (6): 1170-1186. 18 March 2021

Cold-shock domains - abundance, structure, properties, and nucleic-acid binding.
Heinemann, U. and Roske, Y.
Cancers 13 (2): 190. 7 January 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S. and Heimann, A. and Obermayer, B. and Ciraolo, E. and Althoff, S. and Ruß, J. and Grunert, C. and Busse, A. and Bullinger, L. and Pezzutto, A. and Blankenstein, T. and Beule, D. and Na, I.K.
International Journal of Cancer 18 February 2021 (In Press)

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine : e13191. 5 February 2021 (In Press)

Public health antibody screening indicates a six-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M. and Holthaus, L. and Assfalg, R. and Zapardiel Gonzalo, J.M. and Kapfelsperger, H. and Heigermoser, M. and Haupt, F. and Ewald, D.A. and Welzhofer, T.C. and Marcus, B.A. and Heck, S. and Koelln, A. and Stock, J. and Voss, F. and Secchi, M. and Piemonti, L. and de la Rosa, K. and Protzer, U. and Boehmer, M. and Achenbach, P. and Lampasona, V. and Bonifacio, E. and Ziegler, A.G.
Med 2 (2): 149-163. 12 February 2021

Mit Einzelzell-Genomik die Entscheidungen von Zellen verfolgen [Deciphering cell fate decisions using single cell genomics].
Hu, B. and Junker, J.P.
BIOspektrum 27 (1): 25-27. February 2021

Cellular drivers of injury response and regeneration in the adult zebrafish heart.
Hu, B. and Lelek, S. and Spanjaard, B. and Simões, M.G. and Aliee, H. and Schäfer, R. and Theis, F. and Panáková, D. and Junker, J.P.
bioRxiv : 2021.01.07.425670. 7 January 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. and Sigal, M.
International Journal of Medical Microbiology 311 (3): 151486. April 2021

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J. and Michaelis, E. and Greuel, S. and Heynol, V. and Lehmann, A. and Radbruch, H. and Meinhardt, J. and Miller, F. and Herbst, H. and Corman, V.M. and Westermann, J. and Bullinger, L. and Horst, D. and von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103 : 628-635. February 2021

Monitoring mitochondrial translation by pulse SILAC.
Imami, K. and Selbach, M. and Ishihama, Y.
bioRxiv : 2021.01.31.428997. 1 February 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F. and Dahlmann, M. and Sporbert, A. and Mattioli, C.C. and Mari, T. and Scholz, F. and Timm, L. and Twamley, S. and Migotti, R. and Walther, W. and Dittmar, G. and Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 20 January 2021 (In Press)

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold.
Irmscher, T. and Roske, Y. and Gayk, I. and Dunsing, V. and Chiantia, S. and Heinemann, U. and Barbirz, S.
Journal of Biological Chemistry 296 : 100286. 2021

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells.
Kath, J. and Du, W. and Thommandru, B. and Turk, R. and Amini, L. and Stein, M. and Zittel, T. and Martini, S. and Ostendorf, L. and Wilhelm, A. and Akyuez, L. and Rehm, A. and Hoepken, U.E. and Pruss, A. and Kuenkele, A. and Jacobi, A.M. and Volk, H.D. and Schmueck-Henneresse, M. and Reinke, P. and Wagner, D.L.
bioRxiv : 2021.02.14.431017. 14 February 2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Klionsky, D.J. and Abdel-Aziz, A.K. and Abdelfatah, S. and Abdellatif, M. and Abdoli, A. and Abel, S. and Abeliovich, H. and Abildgaard, M.H. and Abudu, Y.P. and Acevedo-Arozena, A. and Adamopoulos, I.E. and Adeli, K. and Adolph, T.E. and Adornetto, A. and Aflaki, E. and Agam, G. and Agarwal, A. and Aggarwal, B.B. and Agnello, M. and Agostinis, P. and Agrewala, J.N. and Agrotis, A. and Aguilar, P.V. and Ahmad, S.T. and Ahmed, Z.M. and Ahumada-Castro, U. and Aits, S. and Aizawa, S. and Akkoc, Y. and Akoumianaki, T. and Akpinar, H.A. and Al-Abd, A.M. and Al-Akra, L. and Al-Gharaibeh, A. and Alaoui-Jamali, M.A. and Alberti, S. and Alcocer-Gómez, E. and Alessandri, C. and Ali, M. and Alim Al-Bari, M.A. and Aliwaini, S. and Alizadeh, J. and Almacellas, E. and Almasan, A. and Alonso, A. and Alonso, G.D. and Altan-Bonnet, N. and Altieri, D.C. and Álvarez, E.M.C. and Alves, S. and Alves da Costa, C. and Alzaharna, M.M. and Amadio, M. and Amantini, C. and Amaral, C. and Ambrosio, S. and Amer, A.O. and Ammanathan, V. and An, Z. and Andersen, S.U. and Andrabi, S.A. and Andrade-Silva, M. and Andres, A.M. and Angelini, S. and Ann, D. and Anozie, U.C. and Ansari, M.Y. and Antas, P. and Antebi, A. and Antón, Z. and Anwar, T. and Apetoh, L. and Apostolova, N. and Araki, T. and Araki, Y. and Arasaki, K. and Araújo, W.L. and Araya, J. and Arden, C. and Arévalo, M.A. and Arguelles, S. and Arias, E. and Arikkath, J. and Arimoto, H. and Ariosa, A.R. and Armstrong-James, D. and Arnauné-Pelloquin, L. and Aroca, A. and Arroyo, D.S. and Arsov, I. and Artero, R. and Asaro, D.M.L. and Aschner, M. and Ashrafizadeh, M. and Ashur-Fabian, O. and Atanasov, A.G. and Au, A.K. and Auberger, P. and Auner, H.W. and Aurelian, L. and Autelli, R. and Avagliano, L. and Ávalos, Y. and Aveic, S. and Aveleira, C.A. and Avin-Wittenberg, T. and Aydin, Y. and Ayton, S. and Ayyadevara, S. and Azzopardi, M. and Baba, M.u and Backer, J.M. and Backues, S.K. and Bae, D.H. and Bae, O.N. and Bae, S.H. and Baehrecke, E.H. and Baek, A. and Baek, S.H. and Baek, S.H. and Bagetta, G. and Bagniewska-Zadworna, A. and Bai, H. and Bai, J. and Bai, X. and Bai, Y. and Bairagi, N. and Baksi, S. and Balbi, T. and Baldari, C.T. and Balduini, W. and Ballabio, A. and Ballester, M. and Balazadeh, S. and Balzan, R. and Bandopadhyay, R. and Banerjee, S. and Banerjee, S. and Bánréti, A. and Bao, Y. and Baptista, M.S. and Baracca, A. and Barbati, C. and Bargiela, A. and Barilà, D. and Barlow, P.G. and Barmada, S.J. and Barreiro, E. and Barreto, G.E. and Bartek, J. and Bartel, B. and Bartolome, A. and Barve, G.R. and Basagoudanavar, S.H. and Bassham, D.C. and Bast, R.C. and Basu, A. and Batoko, H. and Batten, I. and Baulieu, E.E. and Baumgarner, B.L. and Bayry, J. and Beale, R. and Beau, I. and Beaumatin, F. and Bechara, L.R.G. and Beck, G.R. and Beers, M.F. and Begun, J. and Behrends, C. and Behrens, G.M.N. and Bei, R. and Bejarano, E. and Bel, S. and Behl, C. and Belaid, A. and Belgareh-Touzé, N. and Bellarosa, C. and Belleudi, F. and Belló Pérez, M. and Bello-Morales, R. and Beltran, J.S.O. and Beltran, S. and Benbrook, D.M. and Bendorius, M. and Benitez, B.A. and Benito-Cuesta, I. and Bensalem, J. and Berchtold, M.W. and Berezowska, S. and Bergamaschi, D. and Bergami, M. and Bergmann, A. and Berliocchi, L. and Berlioz-Torrent, C. and Bernard, A. and Berthoux, L. and Besirli, C.G. and Besteiro, S. and Betin, V.M. and Beyaert, R. and Bezbradica, J.S. and Bhaskar, K. and Bhatia-Kissova, I. and Bhattacharya, R. and Bhattacharya, S. and Bhattacharyya, S. and Bhuiyan, M.S. and Bhutia, S.K. and Bi, L. and Bi, X. and Biden, T.J. and Bijian, K. and Billes, V.A. and Binart, N. and Bincoletto, C. and Birgisdottir, A.B. and Bjorkoy, G. and Blanco, G. and Blas-Garcia, A. and Blasiak, J. and Blomgran, R. and Blomgren, K. and Blum, J.S. and Boada-Romero, E. and Boban, M. and Boesze-Battaglia, K. and Boeuf, P. and Boland, B. and Bomont, P. and Bonaldo, P. and Bonam, S.R. and Bonfili, L. and Bonifacino, J.S. and Boone, B.A. and Bootman, M.D. and Bordi, M. and Borner, C. and Bornhauser, B.C. and Borthakur, G. and Bosch, J. and Bose, S. and Botana, L.M. and Botas, J. and Boulanger, C.M. and Boulton, M.E. and Bourdenx, M. and Bourgeois, B. and Bourke, N.M. and Bousquet, G. and Boya, P. and Bozhkov, P.V. and Bozi, L.H.M. and Bozkurt, T.O. and Brackney, D.E. and Brandts, C.H. and Braun, R.J. and Braus, G.H. and Bravo-Sagua, R. and Bravo-San Pedro, J.M. and Brest, P. and Bringer, M.A. and Briones-Herrera, A. and Broaddus, V.C. and Brodersen, P. and Brodsky, J.L. and Brody, S.L. and Bronson, P.G. and Bronstein, J.M. and Brown, C.N. and Brown, R.E. and Brum, P.C. and Brumell, J.H. and Brunetti-Pierri, N. and Bruno, D. and Bryson-Richardson, R.J. and Bucci, C. and Buchrieser, C. and Bueno, M. and Buitrago-Molina, L.E. and Buraschi, S. and Buch, S. and Buchan, J.R. and Buckingham, E.M. and Budak, H. and Budini, M. and Bultynck, G. and Burada, F. and Burgoyne, J.R. and Burón, M.I. and Bustos, V. and 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Clinical Research in Cardiology 110 (2): 200-210. February 2021

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C. and Luecken, M.D. and Eraslan, G. and Sikkema, L. and Waghray, A. and Heimberg, G. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smillie, C. and Jagadeesh, K.A. and Duong, E.T. and Fiskin, E. and Triglia, E.T. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Callori, S. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Cuomo, A.S.E. and Deprez, M. and Duclos, G. and Fine, D. and Fischer, D.S. and Ghazanfar, S. and Gillich, A. and Giotti, B. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Hu, Y. and Jaiswal, A. and Ji, L. and Jiang, P. and Kapellos, T.S. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Ludwig, L.S. and Lukassen, S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Leroy, S. and Mayr, C.H. and Mbano, I.M. and McAdams, A.M. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J.C. and Shea, C.V. and Shi, X. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N.P. and Sountoulidis, A. and Strunz, M. and Sullivan, T.B. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K.A. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Xu, K. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27 (3): 546-559. 2 March 2021

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R. and Hilal, T. and Schmidt, S. and Qin, B. and Schwefel, D. and Vieira-Vieira, C.H. and Mielke, T. and Bürger, J. and Loerke, J. and Amikura, K. and Flügel, T. and Ueda, T. and Selbach, M. and Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81 (6): 1200-1215. 18 March 2021

Maternal angiotensin increases placental leptin in early gestation via an alternative renin-angiotensin system pathway: suggesting a link to preeclampsia.
Nonn, O. and Fischer, C. and Geisberger, S. and El-Heliebi, A. and Kroneis, T. and Forstner, D. and Desoye, G. and Staff, A.C. and Sugulle, M. and Dechend, R. and Pecks, U. and Kollmann, M. and Stern, C. and Cartwright, J.E. and Whitley, G.S. and Thilaganathan, B. and Wadsack, C. and Huppertz, B. and Herse, F. and Gauster, M.
Hypertension 77 (5): 1723-1736. May 2021

Longitudinal omics in Syrian hamsters integrated with human data unravel cellular effector responses to moderate COVID-19.
Nouailles, Geraldine and Wyler, E. and Pennitz, P. and Postmus, D. and Vladrimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M.l and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Research Square : rs-148392/v1. 28 January 2021

Whole-genome doubling-aware copy number phylogenies for cancer evolution with MEDICC2.
Petkovic, M. and Watkins, T.B.K. and Colliver, E.C. and Laskina, S. and Swanton, C. and Haase, K. and Schwarz, R.F.
bioRxiv : 2021.02.28.433227. 28 February 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L. and Jarosch, E. and Zauber, H. and Kniss, A. and Waltho, A. and Bagola, K. and von Delbrück, M. and Löhr, F. and Schulman, B.A. and Selbach, M. and Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads.
Porubsky, D. and Ebert, P. and Audano, P.A. and Vollger, M.R. and Harvey, W.T. and Marijon, P. and Ebler, J. and Munson, K.M. and Sorensen, M. and Sulovari, A. and Haukness, M. and Ghareghani, M. and Lansdorp, P.M. and Paten, B. and Devine, S.E. and Sanders, A.D. and Lee, C. and Chaisson, M.J.P. and Korbel, J.O. and Eichler, E.E. and Marschall, T.
Nature Biotechnology 39 (3): 302-308. March 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 11 February 2021 (In Press)

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.
Rapaport, F. and Neelamraju, Y. and Baslan, T. and Hassane, D. and Gruszczynska, A. and de Massy, M.R. and Farnoud, N. and Haddox, S. and Lee, T. and Medina-Martinez, J. and Sheridan, C. and Thurmond, A. and Becker, M. and Bekiranov, S. and Carroll, M. and Moses Murdock, H. and Valk, P.J.M. and Bullinger, L. and D’Andrea, R. and Lowe, S.W. and Neuberg, D. and Levine, R.L. and Melnick, A. and Garrett-Bakelman, F.E.
Leukemia 12 February 2021 (In Press)

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.
Rivera, M. and Fichtner, I. and Wulf-Goldenberg, A. and Sers, C. and Merk, J. and Patone, G. and Alp, K.M. and Kanashova, T. and Mertins, P. and Hoffmann, J. and Stein, U. and Walther, W.
Neoplasia 23 (1): 21-35. January 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I. and Poon, E. and Henssen, A.G. and Dorado Garcia, H. and Gatti, M. and Giansanti, C. and Jamin, Y. and Ade, C.P. and Gallant, P. and Schülein-Völk, C. and Beli, P. and Richards, M. and Rosenfeldt, M. and Altmeyer, M. and Anderson, J. and Eggert, A. and Dobbelstein, M. and Bayliss, R. and Chesler, L. and Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1.
Rybak-Wolf, A. and Wyler, E. and Legnini, I. and Loewa, A. and Glažar, P. and Kim, S.J. and Pentimalli, T.M. and Oliveras Martinez, A. and Beyersdorf, B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
bioRxiv : 2021.03.05.434122. 7 March 2021

Charting a DNA repair roadmap for immunoglobulin class switch recombination.
Saha, T. and Sundaravinayagam, D. and Di Virgilio, M.
Trends in Biochemical Sciences 46 (3): 184-199. March 2021

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
Schmalbrock, L.K. and Dolnik, A. and Cocciardi, S. and Sträng, E. and Theis, F. and Jahn, N. and Panina, E. and Blätte, T.J. and Herzig, J.K. and Skambraks, S. and Rücker, F.G. and Gaidzik, V.I. and Paschka, P. and Fiedler, W. and Salih, H.R. and Wulf, G.G. and Schroeder, T. and Lübbert, M. and Schlenk, R.F. and Thol, F. and Heuser, M. and Larson, R.A. and Ganser, A. and Stunnenberg, H.G. and Minucci, S. and Stone, R.M. and Bloomfield, C.D. and Döhner, H. and Döhner, K. and Bullinger, L.
Blood 19 February 2021 (In Press)

TFE3 activation in a TSC1-altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms.
Schmiester, M. and Dolnik, A. and Kornak, U. and Pfitzner, B. and Hummel, M. and Treue, D. and Hartmann, A. and Agaimy, A. and Weyerer, V. and Lekaj, A. and Brakemeier, S. and Peters, R. and Öllinger, R. and Märdian, S. and Bullinger, L. and Striefler, J.K. and Flörcken, A.
Journal of Pathology Clinical Research 7 (1): 3-9. January 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. and Company, C. and Dramaretska, Y. and Barozzi, I. and Göhrig, A. and Kertalli, S. and Großmann, M. and Naumann, H. and Sánchez-Bailón, M.P. and Hulsman, D. and Glass, R. and Squatrito, M. and Serresi, M. and Gargiulo, G.
Cancer Discovery 11 (3): 754-777. March 2021

The SUMO pathway in pancreatic cancer: insights and inhibition.
Schneeweis, C. and Hassan, Z. and Schick, M. and Keller, U. and Schneider, G.
British Journal of Cancer 124 (3): 531-538. 2 February 2021

NEMHESYS - European perspective on the implementation of next-generation sequencing into clinical diagnostics.
Serramito-Gómez, I. and Clarke, K.M. and Rodríguez-Vicente, A.E. and McGimpsey, J.E. and Abáigar, M. and Díez, C.B. and Benito, R. and Bullinger, L. and Mills, K.I. and Hernández Rivas, J.M.
HemaSphere 5 (3): e541. March 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A. and Grunewald, L. and Anders, K. and Klaus, A. and Schwiebert, S. and Winkler, A. and Stecklum, M. and Rolff, J. and Henssen, A.G. and Höpken, U.E. and Eggert, A. and Schulte, J.H. and Jensen, M.C. and Blankenstein, T. and Künkele, A.
Cancers 13 (5): 1050. 2 March 2021

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S.H. and Vonficht, D. and Jopp-Saile, L. and Raffel, S. and Lutz, R. and Leonce, D. and Ordoñez-Rueda, D. and Ramasz, B. and Boch, T. and Jann, J.C. and Nowak, D. and Hofmann, W.K. and Müller-Tidow, C. and Hübschmann, D. and Alexandrov, T. and Benes, V. and Trumpp, A. and Paulsen, M. and Velten, L. and Haas, S.
bioRxiv : 2021.03.18.435922. 19 March 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L. and Story, B.A. and Hernández-Malmierca, P. and Raffel, S. and Leonce, D.R. and Milbank, J. and Paulsen, M. and Demir, A. and Szu-Tu, C. and Frömel, R. and Lutz, C. and Nowak, D. and Jann, J.C. and Pabst, C. and Boch, T. and Hofmann, W.K. and Müller-Tidow, C. and Trumpp, A. and Haas, S. and Steinmetz, L.M.
Nature Communications 12 (1): 1366. 1 March 2021

Early response to first-line anti-PD-1 treatment in Hodgkin lymphoma: a PET-based analysis from the prospective, randomized phase II NIVAHL trial.
Voltin, C.A. and Mettler, J. and van Heek, L. and Goergen, H. and Müller, H. and Baues, C. and Keller, U. and Meissner, J. and Trautmann-Grill, K. and Kerkhoff, A. and Fuchs, M. and Sasse, S. and von Tresckow, B. and Dietlein, M. and Borchmann, P. and Engert, A. and Kobe, C. and Bröckelmann, P.J.
Clinical Cancer Research 27 (2): 402-407. January 2021

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression.
Walter, S. and Franke, V. and Drayman, N. and Wyler, E. and Tay, S. and Landthaler, M. and Akalin, A. and Ensser, A. and Full, F.
bioRxiv : 2021.03.24.436599. 24 March 2021

HunFlair: an easy-to-use tool for state-of-the-art biomedical named entity recognition.
Weber, L. and Sänger, M. and Münchmeyer, J. and Habibi, M. and Leser, U. and Akbik, A.
Bioinformatics : btab042. 28 January 2021 (In Press)

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
Epigenetics & Chromatin 14 (1): 8. 19 January 2021

Myeloid transformation by MLL-ENL depends strictly on C/EBP.
Wesolowski, R. and Kowenz-Leutz, E. and Zimmermann, K. and Dörr, D. and Hofstätter, M. and Slany, R.K. and Mildner, A. and Leutz, A.
Life Science Alliance 4 (1): e202000709. January 2021

The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Wilhelmi, Ilka and Grunwald, S. and Gimber, N. and Popp, O. and Dittmar, G. and Arumughan, A. and Wanker, E.E. and Laeger, T. and Schmoranzer, J. and Daumke, O. and Schümann, A.
Molecular Metabolism 45 : 101151. March 2021

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg, L. and Paolantoni, C. and Longhi, S. and Mulorz, M.M. and Lence, T. and Wessels, H.H. and Dassi, E. and Aiello, G. and Sutandy, F.X.R. and Scheibe, M. and Edupuganti, R.R. and Busch, A. and Möckel, M.M. and Vermeulen, M. and Butter, F. and König, J. and Notarangelo, M. and Ohler, U. and Dieterich, C. and Quattrone, A. and Soldano, A. and Roignant, J.Y.
EMBO Journal 40 (4): e104975. 15 February 2021

Wnt signalling pathway in bladder cancer.
Wu, G. and Weng, W. and Xia, P. and Yan, S. and Zhong, C. and Xie, L. and Xie, Y. and Fan, G.
Cellular Signalling 79 : 109886. March 2021

Identification of unique long non-coding RNAs as putative biomarkers for chromophobe renal cell carcinoma.
Wu, G. and Xia, P. and Yan, S. and Chen, D. and Xie, L. and Fan, G.
Personalized Medicine 18 (1): 9-19. January 2021

Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
Wulf, G.G. and Altmann, B. and Ziepert, M. and D'Amore, F. and Held, G. and Greil, R. and Tournilhac, O. and Relander, T. and Viardot, A. and Wilhelm, M. and Wilhelm, C. and Pezzutto, A. and Zijlstra, J.M. and Van Den Neste, E. and Lugtenburg, P.J. and Doorduijn, J.K. and van Gelder, M. and van Imhoff, G.W. and Zettl, F. and Braulke, F. and Nickelsen, M. and Glass, B. and Rosenwald, A. and Gaulard, P. and Loeffler, M. and Pfreundschuh, M. and Schmitz, N. and Trümper, L.
Leukemia 35 (1): 143-155. January 2021

Patient-derived xenografts from solid tumors (PDX) for models of metastasis.
Wulf-Goldenberg, A. and Hoffmann, J. and Becker, M. and Brzezicha, B. and Walther, W.
Methods in Molecular Biology 2294 : 43-58. 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsiè, R. and Klironomos, F. and Koppstein, D. and Hönzke, K. and Ayoub, S. and Buccitelli, C. and Hoffmann, K. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J. and Praktiknjo, S. and Meyer, T.F. and Müller, M.A. and Niemeyer, D. and Hocke, A. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
iScience 24 (3): 102151. 19 March 2021

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
Xiao, H. and Wyler, E. and Milek, M. and Grewe, B. and Kirchner, P. and Ekici, A. and Silva, A.B.O.V. and Jungnickl, D. and Full, F. and Thomas, M. and Landthaler, M. and Ensser, A. and Überla, K.
mBio 12 (1): e02525-20. 19 January 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y. and Lahmann, I. and Baum, K. and Shimojo, H. and Mourikis, P. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

2020

Pan-cancer analysis of whole genomes.

Nature 578 (7793): 82-93. 6 February 2020

Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment.
Al-Sabah, J. and Baccin, C. and Haas, S.
Current Opinion in Oncology 32 (2): 146-153. 1 March 2020

Tumor-derived extracellular vesicles impair CD171-specific CD4(+) CAR T cell efficacy.
Ali, S. and Toews, K. and Schwiebert, S. and Klaus, A. and Winkler, A. and Grunewald, L. and Oevermann, L. and Deubzer, H.E. and Tüns, A. and Jensen, M.C. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Schwich, E. and Rebmann, V. and Schramm, A. and Künkele, A.
Frontiers in Immunology 11 : 531. 31 March 2020

Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways.
Aliee, H. and Massip, F. and Qi, C. and Stella de Biase, M. and van Nijnatten, J.L. and Kersten, E.T.G. and Kermani, N.Z. and Khuder, B. and Vonk, J.M. and Vermeulen, R.C.H. and Neighbors, M. and Tew, G.W. and Grimbaldeston, M. and Ten Hacken, N.H.T. and Hu, S. and Guo, Y. and Zhang, X. and Sun, K. and Hiemstra, P.S. and Ponder, B.A. and Makela, M.J. and Malmstrom, K. and Rintoul, R.C. and Reyfman, P.A. and Theis, F.J. and Brandsma, C.A. and Adcock, I. and Timens, W. and Xu, C.J. and van den Berge, M. and Schwarz, R.F. and Koppelman, G.H. and Nawijn, M.C. and Faiz, A.
medRxiv : 2020.08.31.20169946. 2 September 2020

Inter-individual and inter-strain differences in cognitive and social abilities of Dark Agouti and Wistar Han rats.
Alonso, L. and Peeva, P. and Ramos-Prats, A. and Alenina, N. and Winter, Y. and Rivalan, M.
Behavioural Brain Research 377 : 112188. 13 January 2020

Order and disorder: abnormal 3D chromatin organization in human disease.
Anania, C. and Lupianez, D.G.
Briefings in Functional Genomics 19 (2): 128-138. March 2020

Early life stress regulates cardiac development through an IL4-glucocorticoid signaling balance.
Apaydin, D.C. and Jaramillo, P.A.M. and Corradi, L. and Cosco, F. and Rathjen, F.G. and Kammertoens, T. and Filosa, A. and Sawamiphak, S.
Cell Reports 33 (7): 108404. 17 November 2020

Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas.
Arnold, A. and Daum, S. and von Winterfeld, M. and Berg, E. and Hummel, M. and Rau, B. and Stein, U. and Treese, C.
Clinical and Translational Oncology 22 (12): 2357-2363. December 2020

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
Babaian, A. and Rothe, K. and Girodat, D. and Minia, I. and Djondovic, S. and Milek, M. and Spencer Miko, S.E. and Wieden, H.J. and Landthaler, M. and Morin, G.B. and Mager, D.L.
Cell Reports 31 (5): 107611. 5 May 2020

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
Baccin, C. and Al-Sabah, J. and Velten, L. and Helbling, P.M. and Grünschläger, F. and Hernández-Malmierca, P. and Nombela-Arrieta, C. and Steinmetz, L.M. and Trumpp, A. and Haas, S.
Nature Cell Biology 22 (1): 38-48. January 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H. and Meyerson, W.U. and Dursi, L.J. and Wang, L.B. and Dong, G. and Liang, W.W. and Weerasinghe, A. and Li, S. and Li, Y. and Kelso, S. and Saksena, G. and Ellrott, K. and Wendl, M.C. and Wheeler, D.A. and Getz, G. and Simpson, J.T. and Gerstein, M.B. and Ding, Li
Nature Communications 11 (1): 4748. 21 September 2020

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability.
Barbosa, R.R. and Xu, A.Q. and D'Andrea, D. and Copley, F. and Patel, H. and Chakravarty, P. and Clear, A. and Calaminici, M. and Janz, M. and Zhang, B. and Schmidt-Supprian, M. and Wang, J. and Gribben, J.G. and Tooze, R. and Fitzgibbon, J. and Franzoso, G. and Rajewsky, K. and Calado, D.P.
bioRxiv : 2020.04.12.038414. 13 April 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting Histone H2A-K15 ubiquitination.
Bashir, S. and Dang, T. and Rossius, J. and Wolf, J. and Kuehn, R.
BMC Biotechnology 20 (1): 57. 23 October 2020

CD40 provides immune privilege to the bone marrow hematopoietic niche.
Bassani, B. and Gulino, A. and Portararo, P. and Botti, L. and Cappetti, B. and Chiodoni, C. and Bolli, N. and Ciciarello, M. and Joehrens, K. and Anagnostopoulos, I. and Na, I.K. and Curti, A. and Tripodo, C. and Colombo, M.P. and Sangaletti, S.
bioRxiv : 2020.08.10.243691. 10 August 2020

Unblending of transcriptional condensates in human repeat expansion disease.
Basu, S. and Mackowiak, S.D. and Niskanen, H. and Knezevic, D. and Asimi, V. and Grosswendt, S. and Geertsema, H. and Ali, S. and Jerković, I. and Ewers, H. and Mundlos, S. and Meissner, A. and Ibrahim, D.M. and Hnisz, D.
Cell 181 (5): 1062-1079. 28 May 2020

Establishment of kidney cancer organoid cultures.
Bauer, D. and Birchmeier, W. and Fendler, A.
Research Square : rs.3.pex-911. 12 May 2020

LoopDetect: comprehensive feedback loop detection in ordinary differential equation models.
Baum, K. and Wolf, J.
bioRxiv : 2020.11.15.383703. 17 November 2020

Analysing central metabolism in ultra-high resolution: at the crossroads of carbon and nitrogen.
Bayram, S. and Fürst, S. and Forbes, M. and Kempa, S.
Molecular Metabolism 33 : 38-47. 19 March 2020

Disentangling pro-mitotic signaling during cell cycle progression using time-resolved single-cell imaging.
Benary, M. and Bohn, S. and Lüthen, M. and Nolis, I.K. and Blüthgen, N. and Loewer, A.
Cell Reports 31 (2): 107514. 14 April 2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
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Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
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British Journal of Cancer 122 (2): 233-244. 21 January 2020

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
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Gut 69 (8): 1472-1482. August 2020

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
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Nature Communications 11 (1): 4845. 24 September 2020

VISOR: a versatile haplotype-aware structural variant simulator for short- and long-read sequencing.
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Bioinformatics 36 (4): 1267-1269. 15 February 2020

Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
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mRNAs, proteins and the emerging principles of gene expression control.
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Nature Reviews Genetics 21 (10): 630-644. October 2020

Decoding and targeting the molecular basis of MACC1-driven metastatic spread: lessons from big data mining and clinical-experimental approaches.
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Human and mouse essentiality screens as a resource for disease gene discovery.
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Quantification of translation uncovers the functions of the alternative transcriptome.
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Nature Structural & Molecular Biology 27 (8): 717-725. August 2020

Single-cell lineage tracing approaches in hematology research: technical considerations.
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What is extrachromosomal circular DNA and what does it do?
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Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
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Nature Communications 11 (1): 1293. 10 March 2020

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.
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Endothelial damage and dysfunction in acute graft-versus-host disease.
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Haematologica 16 July 2020 (In Press)

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
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SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency.
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bioRxiv : 2020.10.12.318808. 12 October 2020

Restoring treatment response in colorectal cancer cells by targeting MACC1-dependent ABCB1 expression in combination therapy.
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Frontiers in Oncology 10 : 599. 23 April 2020

Novel targets of protoporphyrin-IX determined by gene expression analysis.
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International Journal of Clinical Oncology and Cancer Research 5 (3): 56-64. September 2020

The pierced lasso topology leptin has a bolt on dynamic domain composed by the disordered loops I and III.
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A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
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bioRxiv : 2020.05.11.088252. 12 May 2020

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
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bioRxiv : 2020.01.30.917062. 31 January 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
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Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
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JCI Insight 5 (7): e131093. 9 April 2020

HMGXB4 targets Sleeping Beauty transposition to vertebrate germinal stem sells.
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bioRxiv : 2020.06.15.145656. 15 June 2020

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.
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Journal of Structural Biology 211 (2): 107536. 1 August 2020

Longtime outcome after intraosseous application of autologous mesenchymal stromal cells in pediatric patients and young adults with avascular necrosis after steroid or chemotherapy.
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Stem Cells and Development 29 (13): 811-822. July 2020

Age attenuates the T-type Ca(V) 3.2-RyR axis in vascular smooth muscle.
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Aging Cell 19 (4): e13134. April 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

CD8-specific designed ankyrin repeat proteins improve selective gene delivery into human and primate T lymphocytes.
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Human Gene Therapy 31 (11-12): 679-691. June 2020

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes.
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bioRxiv : 2020.07.15.204388. 16 July 2020

A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
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Molecular Cell 77 (2): 352-367. 16 January 2020

Mechanistic basis for motor-driven membrane constriction by dynamin.
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bioRxiv : 2020.09.10.289546. 11 September 2020

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy.
García, H.D. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Pusch, F.F. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Schulte, J.H. and Haase, K. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
bioRxiv : 2020.12.04.411413. 2020

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes.
Garipler, G. and Lu, C. and Morrissey, A. and Lopez-Zepeda, L.S. and Vidal, S.E. and Aydin, B. and Stadtfeld, M. and Ohler, U. and Mahony, S. and Sanjana, N.E. and Mazzoni, E.O.
bioRxiv : 2020.11.23.391771. 23 November 2020

pH-dependent protonation of surface carboxylate groups in PsbO enables local buffering and triggers structural changes.
Gerland, L. M. and Friedrich, D. and Hopf, L. and Donovan, E. and Wallmann, A. and Erdmann, N. and Diehl, A. and Bommer, M. and Buzar, K. and Ibrahim, M. and Schmieder, P. and Dobbek, H. and Zouni, A. and Bondar, A.-N. and Dau, H. and Oschkinat, H.
ChemBioChem 21 (11): 1597-1604. 2 June 2020

Deep neural networks for interpreting RNA-binding protein target preferences.
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Genome Research 30 (2): 214-226. February 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
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Nature Immunology 21 (5): 525-534. May 2020

GPSeq reveals the radial organization of chromatin in the cell nucleus.
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Nature Biotechnology 38 (10): 1184-1193. October 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
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Cancer Research 80 (6): 1316-1329. March 2020

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus.
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bioRxiv : 2020.09.15.297804. 17 September 2020

MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML.
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bioRxiv : 2020.11.19.389528. 19 November 2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
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Nature Communications 11 (1): 6422. 21 December 2020

Mechanism of virus attenuation by codon pair deoptimization.
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Epigenetic regulator function through mouse gastrulation.
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Nature 584 (7819): 102-108. 6 August 2020

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
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Nature Communications 11 (1): 5506. 2 November 2020

Sarcoma treatment in the era of molecular medicine.
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Saffron crudes and compounds restrict MACC1-dependent cell proliferation and migration of colorectal cancer cells.
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Hematopoietic stem cells in health and disease - insights from single-cell multi-omic approaches.
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Current Stem Cell Reports 6 (3): 67-76. September 2020

Karzinogenese: Big Bang oder kontinuierliche Evolution?
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BIOspektrum 26 (7): 718-720. November 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
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Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Microbe-driven genotoxicity in gastrointestinal carcinogenesis.
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International Journal of Molecular Sciences 21 (20): 7439. 9 October 2020

High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
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Symmetry in nucleic-acid double helices.
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Symmetry 12 (5): 737. 5 May 2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M.E. and Ali, S. and Chamorro González, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Dorado Garcia, H. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Keskeny, C. and Chen, C.Y. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M.I. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
Nature Communications 11 (1): 5823. 16 November 2020

CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
Herhaus, P. and Lipkova, J. and Lammer, F. and Yakushev, I. and Vag, T. and Slotta-Huspenina, J. and Habringer, S. and Lapa, C. and Pukrop, T. and Hellwig, D. and Wiestler, B. and Buck, A.K. and Deckert, M. and Wester, H.J. and Bassermann, F. and Schwaiger, M. and Weber, W.A. and Menze, B. and Keller, U.
Journal of Nuclear Medicine 61 (12): 1765-1771. 1 December 2020

Final results of a phase I/II trial of the combination Bendamustine and Rituximab with Temsirolimus (BeRT) in relapsed mantle cell lymphoma and follicular lymphoma.
Hess, G. and Wagner, K. and Keller, U. and La Rosee, P. and Atta, J. and Hübel, K. and Lerchenmueller, C. and Schoendube, D. and Witzens-Harig, M. and Ruckes, C. and Medler, C. and van Oordt, C. and Klapper, W. and Theobald, M. and Dreyling, M.
HemaSphere 4 (3): e398. June 2020

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness.
Ho, J.S.Y. and Low, D. and Schwarz, M. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J. and Wollman, H. and Chen, L. and An, O. and Chan, T.H.M. and Hickman, A.H. and Zheng, S. and Roudko, V. and Chen, S. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Marazzi, I. and Serresi, M. and Gargiulo, G. and Oliviero, S. and Wee, D.K.B. and Guccione, E.
bioRxiv : 2020.06.17.157537. 18 June 2020

MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma.
Hohmann, T. and Hohmann, U. and Kolbe, M.R. and Dahlmann, M. and Kobelt, D. and Stein, U. and Dehghani, F.
Cell Communication and Signaling 18 (1): 85. 5 June 2020

Spatio-temporal mRNA dynamics in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
bioRxiv : 020.11.19.389809. 20 November 2020

Authentication of primary murine cell lines by a microfluidics-based lab-on-chip system.
Hong, Y. and Singh, N. and Bamopoulos, S. and Gjerga, E. and Schmalbrock, L.K. and Balabanian, K. and Schick, M. and Keller, U. and Wirth, M.
Biomedicines 8 (12): 590. 9 December 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

The International Virus Bioinformatics Meeting 2020.
Hufsky, F. and Beerenwinkel, N. and Meyer, I.M. and Roux, S. and Cook, G.M. and Kinsella, C.M. and Lamkiewicz, K. and Marquet, M. and Nieuwenhuijse, D.F. and Olendraite, I. and Paraskevopoulou, S. and Young, F. and Dijkman, R. and Ibrahim, B. and Kelly, J. and Le Mercier, P. and Marz, M. and Ramette, A. and Thiel, V.
Viruses 12 (12): 1398. 6 December 2020

Clinical outcome of older adults with acute myeloid leukemia: an analysis of a large tertiary referral center over two decades.
Ihlow, J. and Gross, S. and Neuendorff, N.R. and Busack, L. and Herneth, A. and Singh, A. and Schwarz, M. and Flörcken, A. and Anagnostopoulos, I. and Türkmen, S. and Burmeister, T. and Blau, I.W. and Bullinger, L. and Westermann, J.
Journal of Geriatric Oncology 19 November 2020 (In Press)

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.
Jahn, N. and Terzer, T. and Sträng, E. and Dolnik, A. and Cocciardi, S. and Panina, E. and Corbacioglu, A. and Herzig, J. and Weber, D. and Schrade, A. and Götze, K. and Schröder, T. and Lübbert, M. and Wellnitz, D. and Koller, E. and Schlenk, R.F. and Gaidzik, V.I. and Paschka, P. and Rücker, F.G. and Heuser, M. and Thol, F. and Ganser, A. and Benner, A. and Döhner, H. and Bullinger, L. and Döhner, K.
Blood Advances 4 (24): 6342-6352. 22 December 2020

Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.
Jammrath, J. and Reim, I. and Saumweber, H.
PLoS ONE 15 (5): e0233719. 29 May 2020

A randomized open label phase-II clinical trial with or without infusion of plasma from subjects after convalescence of SARS-CoV-2 infection in high-risk patients with confirmed severe SARS-CoV-2 disease (RECOVER): a structured summary of a study protocol for a randomised controlled trial.
Janssen, M. and Schäkel, U. and Djuka Fokou, C. and Krisam, J. and Stermann, J. and Kriegsmann, K. and Haberbosch, I. and Novotny, J.P. and Weber, S. and Vehreschild, M. and Bornhäuser, M. and Bullinger, L. and Schmitt, M. and Liebregts, T. and Dreger, P. and Lorenz, H.M. and Plaszczyca, A. and Bartenschlager, R. and Müller, B. and Kräusslich, H.G. and Halama, N. and Jäger, D. and Schlenk, R.F. and Leo, A. and Meuer, S. and Weigand, M.A. and Motsch, J. and Merle, U. and Denkinger, C.M. and Müller-Tidow, C.
Trials 21 (1): 828. 6 October 2020

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K. and Schnöder, T.M. and Perner, F. and Herzog, C. and Meiler, A. and Krishnamoorthy, G. and Huber, N. and Mohr, J. and Edelmann-Stephan, B. and Austin, R. and Brandt, S. and Palandri, F. and Schröder, N. and Isermann, B. and Edlich, F. and Sinha, A.U. and Ungelenk, M. and Hübner, C.A. and Zeiser, R. and Rahmig, S. and Waskow, C. and Coldham, I. and Ernst, T. and Hochhaus, A. and Jilg, S. and Jost, P.J. and Mullally, A. and Bullinger, L. and Mertens, P.R. and Lane, S.W. and Mann, M. and Heidel, F.H.
Nature 588 (7836): 157-163. 3 December 2020

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions.
Jeuthe, S. and Kemna, J. and Kemna, C.P. and Zocholl, D. and Klopfleisch, R. and Palme, R. and Kirschbaum, C. and Thoene-Reineke, C. and Kammertoens, T.
PLoS ONE 15 (9): e0239231. 30 September 2020

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel.
Jiang, S. and Penack, O. and Terzer, T. and Schult, D. and Majer-Lauterbach, J. and Radujkovic, A. and Blau, I.W. and Bullinger, L. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Haematologica 106 (2): 446-453. February 2020

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.
Jumaa, H. and Caganova, M. and McAllister, E.J. and Hoenig, L. and He, X. and Saltukoglu, D. and Brenker, K. and Köhler, M. and Leben, R. and Hauser, A.E. and Niesner, R. and Rajewsky, K. and Reth, M. and Jellusova, J.
Life Science Alliance 3 (6): e202000700. June 2020

Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis.
Kalogirou, C. and Ellinger, J. and Kristiansen, G. and Hatzichristodoulou, G. and Kübler, H. and Kneitz, B. and Busch, J. and Fendler, A.
Translational Andrology and Urology 9 (3): 1314-1322. June 2020

"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T. and Kemna, J. and Leisegang, M.
EMBO Molecular Medicine 12 (2): e11801. 7 February 2020

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
Kapp-Schwoerer, S. and Weber, D. and Corbacioglu, A. and Gaidzik, V.I. and Paschka, P. and Krönke, J. and Theis, F. and Rücker, F.G. and Teleanu, M.V. and Panina, E. and Jahn, N. and Herzig, J. and Kubanek, L. and Schrade, A. and Göhring, G. and Fiedler, W. and Kindler, T and Schroeder, T. and Mayer, K.T. and Lübbert, M. and Wattad, M. and Götze, K.S. and Horst, H.A. and Koller, E. and Wulf, G. and Schleicher, J. and Bentz, M. and Krauter, J. and Bullinger, L. and Krzykalla, J. and Benner, A. and Schlenk, R.F. and Thol, F. and Heuser, M. and Ganser, A. and Döhner, H and Döhner, K.
Blood 136 (26): 3041-3050. 24 December 2020

Single cell RNA-sequencing-based analysis of CD4(+) T-cell subset-specific susceptibility to transcriptional modulation by HIV-1 latency-reversing agents.
Kazmierski, J. and Postmus, D. and Wyler, E. and Fischer, C. and Jansen, J. and Meixenberger, K. and Vitcetz, S.N. and Sohn, M. and Sauer, S. and Bannert, N. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.05.04.075119. 5 May 2020

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.
Kim, H. and Kim, H. and Feng, Y. and Li, Y. and Tamiya, H. and Tocci, S. and Ronai, Z.A.
Science Translational Medicine 12 (551): eaaz5683. 8 July 2020

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim, H. and Nguyen, N.P. and Turner, K. and Wu, S. and Gujar, A.D. and Luebeck, J. and Liu, J. and Deshpande, V. and Rajkumar, U. and Namburi, S. and Amin, S.B. and Yi, E. and Menghi, F. and Schulte, J.H. and Henssen, A.G. and Chang, H.Y. and Beck, C.R. and Mischel, .S. and Bafna, V. and Verhaak, R.G.W.
Nature Genetics 52 (9): 891-897. September 2020

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer.
Klinghammer, K. and Politz, O. and Eder, T. and Otto, R. and Raguse, J.D. and Albers, A. and Kaufmann, A. and Tinhofer, I. and Hoffmann, J. and Keller, U. and Keilholz, U.
Oncotarget 11 (41): 3688-3697. 13 October 2020

Small ones to fight a big problem-intervention of cancer metastasis by small molecules.
Kobelt, D. and Dahlmann, M. and Dumbani, M. and Güllü, N. and Kortüm, B. and Vílchez, M.E.A. and Stein, U. and Walther, W.
Cancers 12 (6): 1454. 3 June 2020

Pro-inflammatory TNF-α and IFN-γ promote tumor growth and metastasis via induction of MACC1.
Kobelt, D. and Zhang, C. and Clayton-Lucey, I.A. and Glauben, R. and Voss, C. and Siegmund, B. and Stein, U.
Frontiers in Immunology 11 : 980. 27 May 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Konrath, F. and Mittermeier, A. and Cristiano, E. and Wolf, J. and Loewer, A.
PLoS Computational Biology 16 (6): e1007901. 26 June 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Vieira-Vieira, C.H. and Schaub, T. and Harnett, D. and Münster-Wandowski, A. and Bürger, J. and Zinnall, U. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Beule, D. and Landthaler, M. and Mielke, T. and Tarabykin, V. and Vida, I. and Selbach, M. and Spahn, C.M.T.
bioRxiv : 2020.02.08.939488. 10 February 2020

Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
Kroschinsky, F. and Middeke, J.M. and Janz, M. and Lenz, G. and Witzens-Harig, M. and Bouabdallah, R. and La Rosée, P. and Viardot, A. and Salles, G. and Kim, S.J. and Kim, T.M. and Ottmann, O. and Chromik, J. and Quinson, A.M. and von Wangenheim, U. and Burkard, U. and Berk, A. and Schmitz, N.
Investigational New Drugs 38 (5): 1472-1482. October 2020

Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations.
Kutle, I. and Szymańska-de Wijs, K.M. and Bogdanow, B. and Cuvalo, B. and Steinbrück, L. and Jonjić, S. and Wagner, K. and Niedenthal, R. and Selbach, M. and Wiebusch, L. and Dezeljin, M. and Messerle, M.
Journal of Virology 94 (20): e00574-20. October 2020

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates.
Langer, H.T. and Afzal, S. and Kempa, S. and Spuler, S.
Scientific Reports 10 : 1908. 5 February 2020

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.
Lankes, K. and Hassan, Z. and Doffo, M.J. and Schneeweis, C. and Lier, S. and Öllinger, R. and Rad, R. and Krämer, O.H. and Keller, U. and Saur, D. and Reichert, M. and Schneider, G. and Wirth, M.
bioRxiv : 2020.07.01.182162. 2 July 2020

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.
Lankes, K. and Hassan, Z.Z. and Doffo, M.J. and Schneeweis, C. and Lier, S. and Öllinger, R. and Rad, R. and Krämer, O.H. and Keller, U. and Saur, D. and Reichert, M. and Schneider, G. and Wirth, M.
Molecular Oncology 14 (12): 3048-3064. December 2020

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.
Lareau, C.A. and Ludwig, L.S. and Muus, C. and Gohil, S.H. and Zhao, T. and Chiang, Z. and Pelka, K. and Verboon, J.M. and Luo, W. and Christian, E. and Rosebrock, D. and Getz, G. and Boland, G.M. and Chen, F. and Buenrostro, J.D. and Hacohen, N. and Wu, C.J. and Aryee, M.J. and Regev, A. and Sankaran, V.G.
Nature Biotechnology 12 August 2020 (In Press)

Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Lauber, C. and Correia, N. and Trumpp, A. and Rieger, M.A. and Dolnik, A. and Bullinger, L. and Roeder, I. and Seifert, M.
Scientific Reports 10 (1): 12761. 29 July 2020

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S. and Simões, M. and Hu, B. and Alameldeen, A.M.A. and Czajkowski, M.T. and Meyer, A.M. and Ferrara, F. and Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

The chloroplast RNA binding protein CP31A has a preference for mRNAs encoding the subunits of the chloroplast NAD(P)H dehydrogenase complex and is required for their accumulation.
Lenzen, B. and Rühle, T. and Lehniger, M.K. and Okuzaki, A. and Labs, M. and Muino, J.M. and Ohler, U. and Leister, D. and Schmitz-Linneweber, C.
International Journal of Molecular Sciences 21 (16): 5633. 6 August 2020

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C. and Ritterhoff, T. and Weber, A. and Janowska, M.K. and Mustroph, M. and Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Social media big data-based research on the influencing factors of insomnia and spatiotemporal evolution.
Liu, Y. and Luo, Q. and Shen, H. and Zhuang, S. and Xu, C. and Dong, Y. and Sun, Y. and Wang, S. and Deng, H.
IEEE Access 8 : 41516-41529. 28 February 2020

Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.
Loughran, S.J. and Haas, S. and Wilkinson, A.C. and Klein, A.M. and Brand, M.
Experimental Hematology 88 : 1-6. August 2020

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone.
Lutsik, P. and Baude, A. and Mancarella, D. and Öz, S. and Kühn, A. and Toth, R. and Hey, J. and Toprak, U.H. and Lim, J. and Nguyen, V.H. and Jiang, C. and Mayakonda, A. and Hartmann, M. and Rosemann, F. and Breuer, K. and Vonficht, D. and Grünschläger, F. and Lee, S. and Schuhmacher, M.K. and Kusevic, D. and Jauch, A. and Weichenhan, D. and Zustin, J. and Schlesner, M. and Haas, S. and Park, J.H. and Park, Y.J. and Oppermann, U. and Jeltsch, A. and Haller, F. and Fellenberg, J. and Lindroth, A.M. and Plass, C.
Nature Communications 11 (1): 5414. 27 October 2020

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S. and Lim, E.L. and Horswell, S. and Haase, K. and Huebner, A. and Dietzen, M. and Mourikis, T.P. and Watkins, T.B.K. and Rowan, A. and Dewhurst, S.M. and Birkbak, N.J. and Wilson, G.A. and Van Loo, P. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature Genetics 52 (3): 283-293. March 2020

Single-cell strand sequencing of a macaque genome reveals multiple nested inversions and breakpoint reuse during primate evolution.
Maggiolini, F.A.M. and Sanders, A.D. and Shew, C.J. and Sulovari, A. and Mao, Y. and Puig, M. and Catacchio, C.R. and Dellino, M. and Palmisano, D. and Mercuri, L. and Bitonto, M. and Porubský, D. and Cáceres, M. and Eichler, E.E. and Ventura, M. and Dennis, M.Y. and Korbel, J.O. and Antonacci, F.
Genome Research 30 (11): 1680-1693. November 2020

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Marchetto, A. and Ohmura, S. and Orth, M.F. and Knott, M.M.L. and Colombo, M.V. and Arrigoni, C. and Bardinet, V. and Saucier, D. and Wehweck, F.S. and Li, J. and Stein, S. and Gerke, J.S. and Baldauf, M.C. and Musa, J. and Dallmayer, M. and Romero-Pérez, L. and Hölting, T.L.B. and Amatruda, J.F. and Cossarizza, A. and Henssen, A.G. and Kirchner, T. and Moretti, M. and Cidre-Aranaz, F. and Sannino, G. and Grünewald, T.G.P.
Nature Communications 11 (1): 2423. 15 May 2020

GAMIBHEAR: whole-genome haplotype reconstruction from genome architecture mapping data.
Markowski, J. and Kempfer, R. and Kukalev, A. and Irastorza-Azcarate, I. and Loof, G. and Pombo, A. and Schwarz, R.F.
bioRxiv : 2020.01.30.927061. 31 January 2020

AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I. and Roux, P.F. and de Freitas, J.A.N.L.F. and Robinson, L. and Doré, G. and Sun, B. and Belenki, D. and Milanovic, M. and Herbig, U. and Schmitt, C.A. and Gil, J. and Bischof, O.
Nature Cell Biology 22 (7): 842-855. July 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in wildtype and cloche/npas4l mutant zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Kempfer, R. and Mattonet, K. and Hirsekorn, A. and Bilić, I. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
bioRxiv : 2020.06.26.173377. 26 June 2020

Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L. and Höpken, U.E. and Rehm, A.
Frontiers in Immunology 11 : 591741. 3 December 2020

Peptide-based interaction proteomics.
Meyer, K. and Selbach, M.
Molecular & Cellular Proteomics 19 (7): 1070-1075. July 2020

Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Mikuda, N. and Schmidt-Ullrich, R. and Kärgel, E. and Golusda, L. and Wolf, J. and Höpken, U.E. and Scheidereit, C. and Kühl, A.A. and Kolesnichenko, M.
Journal of Pathology 251 (2): 160-174. June 2020

Accelerating drug development for neuroblastoma: summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.
Moreno, L. and Barone, G. and DuBois, S.G. and Molenaar, J. and Fischer, M. and Schulte, J. and Eggert, A. and Schleiermacher, G. and Speleman, F. and Chesler, L. and Geoerger, B. and Hogarty, M.D. and Irwin, M.S. and Bird, N. and Blanchard, G.B. and Buckland, S. and Caron, H. and Davis, S. and De Wilde, B. and Deubzer, H.E. and Dolman, E. and Eilers, M. and George, R.E. and George, S. and Jaroslav, Š. and Maris, J.M. and Marshall, L. and Merchant, M. and Mortimer, P. and Owens, C. and Philpott, A. and Poon, E. and Shay, J.W. and Tonelli, R. and Valteau-Couanet, D. and Vassal, G. and Park, J.R. and Pearson, A.D.J.
European Journal of Cancer 136 : 52-68. September 2020

Variability of an early developmental cell population underlies stochastic laterality defects.
Moreno-Ayala, R. and Olivares-Chauvet, P. and Schäfer, R. and Junker, J.P.
bioRxiv : 2020.07.20.212282. 20 July 2020

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis.
Moreno-Layseca, P. and Jäntti, N.Z. and Godbole, R. and Sommer, C. and Jacquemet, G. and Al-Akhrass, H. and Kronqvist, P. and Kallionpää, R.E. and Oliveira-Ferrer, L. and Cervero, P. and Linder, S. and Aepfelbacher, M. and Rae, J. and Parton, R.G. and Disanza, A. and Scita, G. and Mayor, S. and Selbach, M. and Veltel, S. and Ivaska, J.
bioRxiv : 2020.10.05.323295. 5 October 2020

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y. and Heynen, G.J.J.E. and López-Alberca, M.P. and Paul, J. and Miksche, S. and Radetzki, S. and Schaller, D. and Shanina, E. and Seyffarth, C. and Kolomeets, Y. and Ziebart, N. and de Schryver, J. and Oestreich, S. and Neuenschwander, M. and Roske, Y. and Heinemann, U. and Rademacher, C. and Volkamer, A. and von Kries, J.P. and Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63 (23): 14780-14804. 10 December 2020

A quantitative modular modeling approach reveals the effects of different A20 feedback implementations for the NF-κB signaling dynamics.
Mothes, J. and Ipenberg, I. and Arslan, S.Ç. and Benary, U. and Scheidereit, C. and Wolf, J.
Frontiers in Physiology 11 : 896. 28 July 2020

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells.
Muus, C. and Luecken, M.D. and Eraslan, G. and Waghray, A. and Heimberg, G. and Sikkema, L. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smilie, C. and Jagadeesh, K. and Thu Duong, E. and Fiskin, E. and Torlai Triglia, E. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, A.Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Deprez, M. and Fischer, D.S. and Gillich, A. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Jaiswal, A. and Jiang, P. and Kapellos, T. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Lu, J. and Ludwig, L.S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Marquette, C.H. and Mbano, I. and McAdams, A.M. and Metzger, R.J. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N. and Sountoulidis, A. and Strunz, M. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
bioRxiv : 2020.04.19.049254. 21 April 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Höfler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
bioRxiv : 2020.12.18.423524. 19 December 2020

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.
Oevermann, L. and Zimmermann, C. and Voigt, S. and Künkele, A. and Lobitz, S. and Eggert, A. and Schulte, J.H. and Kaufer, B.B. and Deubzer, H.E.
Bone Marrow Transplantation 55 (1): 260-264. January 2020

Inclusion of temporal information in single cell transcriptomics.
Olivares-Chauvet, P. and Junker, J.P.
International Journal of Biochemistry and Cell Biology 122 : 105745. May 2020

Towards a more reliable identification of isomeric metabolites using pattern guided retention validation.
Opialla, T. and Kempa, S. and Pietzke, M.
Metabolites 10 (11): 457. 12 November 2020

High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma.
Orth, M.F. and Hölting, T.L.B. and Dallmayer, M. and Wehweck, F.S. and Paul, T. and Musa, J. and Baldauf, M.C. and Surdez, D. and Delattre, O. and Knott, M.M.L. and Romero-Pérez, L. and Kasan, M. and Cidre-Aranaz, F. and Gerke, J.S. and Ohmura, S. and Li, J. and Marchetto, A. and Henssen, A.G. and Özen, Ö. and Sugita, S. and Hasegawa, T. and Kanaseki, T. and Bertram, S. and Dirksen, U. and Hartmann, W. and Kirchner, T. and Grünewald, T.G.P.
Cancers 12 (3): 644. 10 March 2020

Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction.
Peitz, C. and Sprüssel, A. and Linke, R.B. and Astrahantseff, K. and Grimaldi, M. and Schmelz, K. and Toedling, J. and Schulte, J.H. and Fischer, M. and Messerschmidt, C. and Beule, D. and Keilholz, U. and Eggert, A. and Deubzer, H.E. and Lodrini, M.
Journal of Molecular Diagnostics 22 (11): 1309-1323. November 2020

Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin.
Piontek, A. and Eichner, M. and Zwanziger, D. and Beier, L.S. and Protze, J. and Walther, W. and Theurer, S. and Schmid, K.W. and Führer-Sakel, D. and Piontek, J. and Krause, G.
Molecular Oncology 14 (2): 261-276. February 2020

Using gradient boosting with stability selection on health insurance claims data to identify disease trajectories in chronic obstructive pulmonary disease.
Ploner, T. and Heß, S. and Grum, M. and Drewe-Boss, P. and Walker, J.
Statistical Methods in Medical Research 29 (12): 3684-3694. 1 December 2020

Recurrent inversion toggling and great ape genome evolution.
Porubsky, D. and Sanders, A.D. and Höps, W. and Hsieh, P. and Sulovari, A. and Li, R. and Mercuri, L. and Sorensen, M. and Murali, S.C. and Gordon, D. and Cantsilieris, S. and Pollen, A.A. and Ventura, M. and Antonacci, F. and Marschall, T. and Korbel, J.O. and Eichler, E.E.
Nature Genetics 52 (8): 849-858. August 2020

breakpointR: an R/Bioconductor package to localize strand state changes in Strand-seq data.
Porubsky, D. and Sanders, A.D. and Taudt, A. and Colomé-Tatché, M. and Lansdorp, P.M. and Guryev, V.
Bioinformatics 36 (4): 1260-1261. 15 February 2020

First-line treatment with R-CHOP or rituximab-bendamustine in patients with follicular lymphoma grade 3A - results of a retrospective analysis.
Pouyiourou, M. and Meyer, A. and Stroux, A. and Viardot, A. and La Rosée, P. and Maschmeyer, G. and Kämpfe, D. and Kahl, C. and Vucinic, V. and Monecke, A. and Hirt, C. and Weber, T. and Meissner, J. and Witzens-Harig, M. and Böttcher, S. and Schmalenberg, H. and Marks, R. and Prange-Krex, G. and Kroschinsky, F. and Hauf, E. and Keller, U. and Koch, K. and Klapper, W. and Herold, M. and Scholz, C.W.
Annals of Hematology 99 (12): 2821-2829. December 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression.
Pötzsch, M. and Berg, E. and Hummel, M. and Stein, U. and von Winterfeld, M. and Jöhrens, K. and Rau, B. and Daum, S. and Treese, C.
OncoImmunology 9 (1): 1824632. 30 September 2020

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer.
Quinn, H. and Koren, E. and Vogel, R. and Popp, O. and Mertins, P. and Messerschmidt, C. and Marangoni, E. and Fuchs, Y. and Birchmeier, W.
bioRxiv : 2020.06.05.115881. 6 June 2020

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S. and Klimmeck, D. and Falcone, M. and Demir, A. and Pouya, A. and Zeisberger, P. and Lutz, C. and Tinelli, M. and Bischel, O. and Bullinger, L. and Thiede, C. and Flörcken, A. and Westermann, J. and Ehninger, G. and Ho, A.D. and Müller-Tidow, C. and Gu, Z. and Herrmann, C. and Krijgsveld, J. and Trumpp, A. and Hansson, J.
Blood 136 (13): 1507-1519. 24 September 2020

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part phase Ib/II study.
Rambaldi, A. and Iurlo, A. and Vannucchi, A.M. and Noble, R. and von Bubnoff, N. and Guarini, A. and Martino, B. and Pezzutto, A. and Carli, G. and De Muro, M. and Luciani, S. and McMullin, M.F. and Cambier, N. and Marolleau, J.P. and Mesa, R.A. and Tibes, R. and Pancrazzi, A. and Gesullo, F. and Bettica, P. and Manzoni, S. and Di Tollo, S.
Leukemia 34 (8): 2234-2237. August 2020

A comprehensive motifs-based interactome of the C/EBPα transcription factor.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
bioRxiv : 2020.12.28.424569. 28 December 2020

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features.
Ray, J.P. and de Boer, C.G. and Fulco, C.P. and Lareau, C.A. and Kanai, M. and Ulirsch, J.C. and Tewhey, R. and Ludwig, L.S. and Reilly, S.K. and Bergman, D.T. and Engreitz, J.M. and Issner, R. and Finucane, H.K. and Lander, E.S. and Regev, A. and Hacohen, N.
Nature Communications 11 (1): 1237. 6 March 2020

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M. and Haas, S.A. and Franchini, P. and Xiong, P. and Simakov, O. and Kuhl, H. and Schöpflin, R. and Heller, D. and Moeinzadeh, M.H. and Heinrich, V. and Krannich, T. and Bressin, A. and Hartmann, M.F. and Wudy, S.A. and Dechmann, D.K.N. and Hurtado, A. and Barrionuevo, F.J. and Schindler, M. and Harabula, I. and Osterwalder, M. and Hiller, M. and Wittler, L. and Visel, A. and Timmermann, B. and Meyer, A. and Vingron, M. and Jiménez, R. and Mundlos, S. and Lupiáñez, D.G.
Science 370 (6513): 208-214. 9 October 2020

Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.
Reddington, J.P. and Garfield, D.A. and Sigalova, O.M. and Karabacak Calviello, A. and Marco-Ferreres, R. and Girardot, C. and Viales, R.R. and Degner, J.F. and Ohler, U. and Furlong, E.E.M.
Developmental Cell 55 (5): 648-664. 7 December 2020

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M. and Schrezenmeier, J.F. and Richter-Pechanska, P. and Dolnik, A. and Hick, T.P. and Schleich, K. and Cai, X. and Fan, D.N.Y. and Lohneis, P. and Masswig, S. and Denker, S. and Busse, A. and Knittel, G. and Flümann, R. and Childs, D. and Childs, L. and Gätjens-Sanchez, A.M. and Bullinger, L. and Rosenwald, A. and Reinhardt, H.C. and Schmitt, C.A.
Blood 24 November 2020 (In Press)

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S. and Bröckelmann, P.J. and Iaccarino, I. and Garcia-Marquez, M. and Borchmann, S. and Jochims, F. and Kotrova, M. and Pal, K. and Brüggemann, M. and Hartmann, E. and Sasse, S. and Kobe, C. and Mathas, S. and Soekler, M. and Keller, U. and Bormann, M. and Zimmermann, A. and Richter, J. and Fuchs, M. and von Tresckow, B. and Borchmann, P. and Schlößer, H. and von Bergwelt-Baildon, M. and Rosenwald, A. and Engert, A. and Klapper, W.
Blood 136 (25): 2851-2863. 17 December 2020

A CD205-directed antibody drug conjugate - lymphoma precision oncology or sophisticated chemotherapy?
Rieke, D.T. and Keller, U.
Haematologica 105 (11): 2504-2506. 1 November 2020

Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H. and Franz, A. and Jung, M. and Weickmann, S. and Ralla, B. and Kilic, E. and Stephan, C. and Fendler, A. and Jung, K.
Theranostics 10 (20): 9268-9279. 23 July 2020

Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological factors.
Rochow, H. and Jung, M. and Weickmann, S. and Ralla, B. and Stephan, C. and Elezkurtaj, S. and Kilic, E. and Zhao, Z. and Jung, K. and Fendler, A. and Franz, A.
International Journal of Molecular Sciences 21 (21): E7812. 22 October 2020

Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y. and Gilboa, T. and van Kooten, X.F. and Kobelt, D. and Huttner, D. and Stein, U. and Meller, A.
ACS Nano 14 (10): 13964-13974. 27 October 2020

Mapping the transglycosylation relevant sites of cold-adapted β-d-galactosidase from arthrobacter sp. 32cB.
Rutkiewicz, M. and Wanarska, M. and Bujacz, A.
International Journal of Molecular Sciences 21 (15): 5354. 28 July 2020

Editorial: Modulation of human immune parameters by anticancer therapies.
Sack, U. and Tarnok, A. and Preijers, F. and Köhl, U. and Na, I.K.
Frontiers in Immunology 11 : 621556. 2 December 2020

Single-cell analysis of structural variations and complex rearrangements with tri-channel processing.
Sanders, A.D. and Meiers, S. and Ghareghani, M. and Porubsky, D. and Jeong, H. and van Vliet, M.A.C.C. and Rausch, T. and Richter-Pechańska, P. and Kunz, J.B. and Jenni, S. and Bolognini, D. and Longo, G.M.C. and Raeder, B. and Kinanen, V. and Zimmermann, J. and Benes, V. and Schrappe, M. and Mardin, B.R. and Kulozik, A.E. and Bornhauser, B. and Bourquin, J.P. and Marschall, T. and Korbel, J.O.
Nature Biotechnology 38 (3): 343-354. March 2020

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Scheer, M. and Blank, B. and Bauer, S. and Vokuhl, C. and Stegmaier, S. and Feuchtgruber, S. and Henssen, A. and Sparber-Sauer, M. and Eggert, A. and Handgretinger, R. and Pekrun, A. and Rossig, C. and Rutkowski, S. and Schlegel, P.G. and Schrappe, M. and Simon, T. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Jahnukainen, K. and Fuchs, J. and Bielack, S.S. and Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 146 (4): 953-960. April 2020

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K. and Kase, J. and Dörr, J.R. and Trescher, S. and Bhattacharya, A. and Yu, Y. and Wailes, E.M. and Fan, D.N.Y. and Lohneis, P. and Milanovic, M. and Lau, A. and Lenze, D. and Hummel, M. and Chapuy, B. and Leser, U. and Reimann, M. and Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS.
Schmidt, K. and Sack, U. and Graf, R. and Winkler, W. and Popp, O. and Mertins, P. and Sommermann, T. and Kocks, C. and Rajewsky, K.
Frontiers in Immunology 11 : 602868. 1 December 2020

A randomized phase 3 trial of auto vs. allo transplantation as part of first-line therapy in poor-risk peripheral T-NHL.
Schmitz, N. and Truemper, L.H. and Bouabdallah, K. and Ziepert, M. and Leclerc, M. and Cartron, G. and Jaccard, A. and Reimer, P. and Wagner-Drouet, E.M. and Wilhelm, M. and Sanhes, L. and Lamy, T. and de Leval, L. and Rosenwald, A. and Roussel, M. and Kroschinsky, F.P. and Lindemann, W.W. and Dreger, P. and Viardot, A. and Milpied, N.J. and Gisselbrecht, C. and Wulf, G.G. and Gyan, E. and Gaulard, P. and Bay, J.O. and Glass, B. and Poeschel, V. and Damaj, G. and Sibon, D. and Delmer, A.J. and Bilger, K. and Banos, A. and Haenel, M. and Dreyling, M. and Metzner, B. and Keller, U. and Braulke, F. and Friedrichs, B. and Nickelsen, M. and Altmann, B. and Tournilhac, O.
Blood 17 December 2020 (In Press)

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D. and Formichetti, S. and Junker, J.P. and Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16 (11): e9946. 1 November 2020

Spatio-temporal bone remodeling after hematopoietic stem cell transplantation.
Schwarz, C.S. and Bucher, C.H. and Schlundt, C. and Mertlitz, S. and Riesner, K. and Kalupa, M. and Verlaat, L. and Schmidt-Bleek, O. and Sass, R.A. and Schmidt-Bleek, K. and Duda, G.N. and Penack, O. and Na, I.K.
International Journal of Molecular Sciences 22 (1): 267. 29 December 2020

A single cell Arabidopsis root atlas reveals developmental trajectories in wild type and cell identity mutants.
Shahan, R. and Hsu, C.W. and Nolan, T.M. and Cole, B.J. and Taylor, I.W. and Vlot, A.H.C. and Benfey, P.N. and Ohler, U.
bioRxiv : 2020.06.29.178863. 30 June 2020

The effects of common structural variants on 3D chromatin structure.
Shanta, O. and Noor, A. and Sebat, J.
BMC Genomics 21 (1): 95. 30 January 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

Human endogenous retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. and Cai, H. and Bunse, M. and Feschotte, C. and Izsvak, Z.
bioRxiv : 2020.05.27.120170. 2 June 2020

Bacteriophages: emerging applications in medicine, food, and biotechnology.
Sohail, H.A. and Coffey, A. and Debrowska, K. and Meyer, I.M. and Middelboe, M. and Sohail, M. and Clokie, M.R.J.
PHAGE 1 (2): 75-82. 16 June 2020

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T. and Yasuda, T. and Ronen, J. and Wirtz, T. and Weber, T. and Sack, U. and Caeser, R. and Zhang, J. and Li, X. and Chu, V.T. and Jauch, A. and Unger, K. and Hodson, D.J. and Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117 (25): 14421-14432. 23 June 2020

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.
Stangl, C. and de Blank, S. and Renkens, I. and Westera, L. and Verbeek, T. and Valle-Inclan, J.E. and González, R.C. and Henssen, A.G. and van Roosmalen, M.J. and Stam, R.W. and Voest, E.E. and Kloosterman, W.P. and van Haaften, G. and Monroe, G.R.
Nature Communications 11 (1): 2861. 5 June 2020

HCoV- and SARS-CoV-2 cross-reactive T cells in CVID patients.
Steiner, S. and Sotzny, F. and Bauer, S. and Na, I.K. and Schmueck-Henneresse, M. and Corman, V.M. and Schwarz, T. and Drosten, C. and Wendering, D.J. and Behrends, U. and Volk, H.D. and Scheibenbogen, C. and Hanitsch, L.G.
Frontiers in Immunology 11 : 607918. 23 December 2020

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
Swan, A.L. and Schütt, C. and Rozman, J. and Del Mar Muñiz Moreno, M. and Brandmaier, S. and Simon, M. and Leuchtenberger, S. and Griffiths, M. and Brommage, R. and Keskivali-Bond, P. and Grallert, H. and Werner, T. and Teperino, R. and Becker, L. and Miller, G. and Moshiri, A. and Seavitt, J.R. and Cissell, D.D. and Meehan, T.F. and Acar, E.F. and Lelliott, C.J. and Flenniken, A.M. and Champy, M.F. and Sorg, T. and Ayadi, A. and Braun, R.E. and Cater, H. and Dickinson, M.E. and Flicek, P. and Gallegos, J. and Ghirardello, E.J. and Heaney, J.D. and Jacquot, S. and Lally, C. and Logan, J.G. and Teboul, L. and Mason, J. and Spielmann, N. and McKerlie, C. and Murray, S.A. and Nutter, L.M.J. and Odfalk, K.F. and Parkinson, H. and Prochazka, J. and Reynolds, C.L. and Selloum, M. and Spoutil, F. and Svenson, K.L. and Vales, T.S. and Wells, S.E. and White, J.K. and Sedlacek, R. and Wurst, W. and Lloyd, K.K.C. and Croucher, P.I. and Fuchs, H. and Williams, G.R. and Bassett, D. and Gailus-Durner, V. and Herault, Y. and Mallon, A.M. and Brown, S.D.M. and Mayer-Kuckuk, P. and Hrabe de Angelis, M.
PLoS Genetics 16 (12): e1009190. 28 December 2020

Towards a deeper annotation of human lncRNAs.
Szcześniak, M.W. and Wanowska, E. and Mukherjee, N. and Ohler, U. and Makałowska, I.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1863 (4): 194385. April 2020

Keeping the proportions of protein complex components in check.
Taggart, J.C. and Zauber, H. and Selbach, M. and Li, G.W. and McShane, E.
Cell Systems 10 (2): 125-132. 26 February 2020

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.
Tausch, E. and Beck, P. and Schlenk, R.F. and Jebaraj, B.M.C. and Dolnik, A. and Yosifov, D.Y. and Hillmen, P. and Offner, F. and Janssens, A. and Babu, K.G. and Grosicki, S. and Mayer, J. and Panagiotidis, P. and McKeown, A. and Gupta, I.V. and Skorupa, A. and Pallaud, C. and Bullinger, L. and Mertens, D. and Döhner, H. and Stilgenbauer, S.
Haematologica 105 (10): 2440-2447. October 2020

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.
Textoris-Taube, K. and Cammann, C. and Henklein, P. and Topfstedt, E. and Ebstein, F. and Henze, S. and Liepe, J. and Zhao, F. and Schadendorf, D. and Dahlmann, B. and Uckert, W. and Paschen, A. and Mishto, M. and Seifert, U.
European Journal of Immunology 50 (2): 270-283. February 2020

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M. and Toedling, J. and Sprüssel, A. and Pfeil, S. and Savelyeva, L. and Capper, D. and Messerschmidt, C. and Beule, D. and Groeneveld-Krentz, S. and Eckert, C. and Gambara, G. and Henssen, A.G. and Finkler, S. and Schulte, J.H. and Sieber, A. and Bluethgen, N. and Regenbrecht, C.R.A. and Künkele, A. and Lodrini, M. and Eggert, A. and Deubzer, H.E.
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

Phosphosite analysis of the cytomegaloviral mRNA export factor pUL69 reveals serines with critical importance for recruitment of cellular proteins Pin1 and UAP56/URH49.
Thomas, M. and Müller, R. and Horn, G. and Bogdanow, B. and Imami, K. and Milbradt, J. and Steingruber, M. and Marschall, M. and Schilling, E.M. and Fossen, T. and Stamminger, T.
Journal of Virology 94 (8): e02151-19. 31 March 2020

Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors.
Timme, N. and Han, Y. and Liu, S. and Yosief, H.O. and García, H.D. and Bei, Y. and Klironomos, F. and MacArthur, I.C. and Szymansky, A. and von Stebut, J. and Bardinet, V. and Dohna, C. and Künkele, A. and Rolff, J. and Hundsdörfer, P. and Lissat, A. and Seifert, G. and Eggert, A. and Schulte, J.H. and Zhang, W. and Henssen, A.G.
Translational Oncology 13 (2): 221-232. February 2020

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma.
Tjaden, B. and Baum, K. and Marquardt, V. and Simon, M. and Trajkovic-Arsic, M. and Kouril, T. and Siebers, B. and Lisec, J. and Siveke, J.T. and Schulte, J.H. and Benary, U. and Remke, M. and Wolf, J. and Schramm, A.
Scientific Reports 10 (1): 7157. 28 April 2020

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
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Journal of Experimental Medicine 217 (7): e20191933. 6 July 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
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Molecular Carcinogenesis 59 (7): 724-273. July 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat Severe Congenital Neutropenia.
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Molecular Therapy 28 (12): 2621-2634. 2 December 2020

Protocol for efficient CRISPR/Cas9/AAV-mediated homologous recombination in mouse hematopoietic stem and progenitor cells.
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STAR Protocols 1 (1): 100028. 19 June 2020

R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48 (18): e105. 9 October 2020

The discriminative ability of Prostate Health Index to detect prostate cancer is enhanced in combination with miR-222-3p.
Tölle, A. and Jung, K. and Friedersdorff, F. and Maxeiner, A. and Lein, M. and Fendler, A. and Stephan, C.
Cancer Biomarkers 18 December 2020 (In Press)

covRNA: discovering covariate associations in large-scale gene expression data.
Urban, L. and Remmele, C.W. and Dittrich, M. and Schwarz, R.F. and Müller, T.
BMC Research Notes 13 (1): 92. 24 February 2020

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review.
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European Journal of Pediatrics 179 : 191-202. February 2020

SEMITONES: Single-cEll Marker IdentificaTiON by Enrichment Scoring.
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bioRxiv : 2020.11.17.386664. 18 November 2020

Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads.
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Annals of Human Genetics 84 (2): 125-140. March 2020

Purifying selection against pathogenic mitochondrial DNA in human T cells.
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New England Journal of Medicine 383 (16): 1556-1563. 15 October 2020

In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe(2) and NHC*-Au-S-GLUC against advanced prostate cancer PC3.
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Anti-Cancer Drugs 31 (7): 672-683. August 2020

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility.
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Science 370 (6523): eabc6617. 18 December 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
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Nature 587 (7832): 126-132. 5 November 2020

PEDL: extracting protein-protein associations using deep language models and distant supervision.
Weber, L. and Thobe, K. and Migueles Lozano, O.A. and Wolf, J. and Leser, U.
Bioinformatics 36 (Suppl 1): i490-i498. July 2020

4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay.
Weber, R. and Chung, M.Y. and Keskeny, C. and Zinnall, U. and Landthaler, M. and Valkov, E. and Izaurralde, E. and Igreja, C.
Cell Reports 33 (2): 108262. 13 October 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system.
Willnow, D. and Benary, U. and Margineanu, A. and Vignola, M.L. and Pongrac, I.M. and Karimaddini, Z. and Vigilante, A. and Wolf, J. and Spagnoli, F.M.
bioRxiv : 2020.08.06.240176. 6 August 2020

Ubiquitination and ubiquitin-like modifications in multiple myeloma: biology and therapy.
Wirth, M. and Schick, M. and Keller, U. and Krönke, J.
Cancers 12 (12): 3764. 14 December 2020

Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.
Wizenty, J. and Tacke, F. and Sigal, M.
Annals of Translational Medicine 8 (8): 568. April 2020

Wegbereiter der modernen Krebsforschung: Theodor Boveri und Otto Warburg [Pioneers of modern cancer research: Theodor Boveri and Otto Warburg].
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BIOspektrum 26 (6): 687-690. November 2020

50 Jahre Reverse Transkriptase [50 years of reverse transcriptase].
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BIOspektrum 26 (3): 343-344. May 2020

Clinical outcome in patients with carcinoma of the esophagogastric junction treated with neoadjuvant radiochemotherapy or perioperative chemotherapy: a two-enter retrospective analysis.
Wundsam, H.V. and Doleschal, B. and Prommer, R. and Venhoda, C. and Schmitt, C. and Petzer, A. and Metz-Gercek, S. and Rumpold, H.
Oncology 98 (10): 706-713. October 2020

Non-thermal effects of radiofrequency electromagnetic fields.
Wust, P. and Kortüm, B. and Strauss, U. and Nadobny, J. and Zschaeck, S. and Beck, M. and Stein, U. and Ghadjar, P.
Scientific Reports 10 (1): 13488. 10 August 2020

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsie, R. and Klironomos, F. and Koppstein, D. and Ayoub, S. and Buccitelli, C. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J.P. and Müller, M.A. and Niemeyer, D. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
bioRxiv : 2020.05.05.079194. 5 May 2020

hGBP1 coordinates chlamydia restriction and inflammasome activation through sequential GTP hydrolysis.
Xavier, A. and Al-Zeer, M.A. and Meyer, T.F. and Daumke, O.
Cell Reports 31 (7): 107667. 19 May 2020

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
Xiao, H. and Wyler, E. and Milek, M. and Grewe, B. and Kirchner, P. and Ekici, A. and Villela Silva, A.B.O. and Jungnickl, D. and Landthaler, M. and Ensser, A. and Überla, K.
bioRxiv : 2020.02.04.934927. 11 February 2020

Overactivation of the NF-κB pathway impairs molar enamel formation.
Yamada, A. and Kawasaki, M. and Miake, Y. and Yamada, Y. and Blackburn, J. and Kawasaki, K. and Trakanant, S. and Nagai, T. and Nihara, J. and Kudo, T. and Meguro, F. and Schmidt-Ullrich, R. and Liu, B. and Hu, Y. and Page, A. and Ramírez, Á. and Sharpe, P.T. and Maeda, T. and Takagi, R. and Ohazama, A.
Oral Diseases 26 (7): 1513-1522. October 2020

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf, R.Z. and Saez, B. and Sharda, A. and van Gastel, N. and Yu, V.W.C. and Baryawno, N. and Scadden, E.W. and Acharya, S. and Chattophadhyay, S. and Huang, C. and Viswanathan, V. and S'aulis, D. and Cobert, J. and Sykes, D.B. and Keibler, M.A. and Das, S. and Hutchinson, J.N. and Churchill, M. and Mukherjee, S. and Lee, D. and Mercier, F. and Doench, J. and Bullinger, L. and Logan, D.J. and Schreiber, S. and Stephanopoulos, G. and Rizzo, W.B. and Scadden, D.T.
Blood 136 (11): 1303-1316. 10 September 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L. and Klaus, A. and Maas, J. and Morin-Poulard, I. and Weijts, B. and Schulte-Merker, S. and Berezikov, E. and Junker, J.P. and Robin, C.
Blood 136 (7): 831-844. 13 August 2020

Monogenic variants in dystonia: an exome-wide sequencing study.
Zech, M. and Jech, R. and Boesch, S. and Škorvánek, M. and Weber, S. and Wagner, M. and Zhao, C. and Jochim, A. and Necpál, J. and Dincer, Y. and Vill, K. and Distelmaier, F. and Stoklosa, M. and Krenn, M. and Grunwald, S. and Bock-Bierbaum, T. and Fečíková, A. and Havránková, P. and Roth, J. and Příhodová, I. and Adamovičová, M. and Ulmanová, O. and Bechyně, K. and Danhofer, P. and Veselý, B. and Haň, V. and Pavelekova, P. and Gdovinová, Z. and Mantel, T. and Meindl, T. and Sitzberger, A. and Schröder, S. and Blaschek, A. and Roser, T. and Bonfert, M.V. and Haberlandt, E. and Plecko, B. and Leineweber, B. and Berweck, S. and Herberhold, T. and Langguth, B. and Švantnerová, J. and Minár, M. and Ramos-Rivera, G.A. and Wojcik, M.H. and Pajusalu, S. and Õunap, K. and Schatz, U.A. and Pölsler, L. and Milenkovic, I. and Laccone, F. and Pilshofer, V. and Colombo, R. and Patzer, S. and Iuso, A. and Vera, J. and Troncoso, M. and Fang, F. and Prokisch, H. and Wilbert, F. and Eckenweiler, M. and Graf, E. and Westphal, D.S. and Riedhammer, K.M. and Brunet, T. and Alhaddad, B. and Berutti, R. and Strom, T.M. and Hecht, M. and Baumann, M. and Wolf, M. and Telegrafi, A. and Person, R.E. and Zamora, F.M. and Henderson, L.B. and Weise, D. and Musacchio, T. and Volkmann, J. and Szuto, A. and Becker, J. and Cremer, K. and Sycha, T. and Zimprich, F. and Kraus, V. and Makowski, C. and Gonzalez-Alegre, P. and Bardakjian, T.M. and Ozelius, L.J. and Vetro, A. and Guerrini, R. and Maier, E. and Borggraefe, I. and Kuster, A. and Wortmann, S.B. and Hackenberg, A. and Steinfeld, R. and Assmann, B. and Staufner, C. and Opladen, T. and Růžička, E. and Cohn, R.D. and Dyment, D. and Chung, W.K. and Engels, H. and Ceballos-Baumann, A. and Ploski, R. and Daumke, O. and Haslinger, B. and Mall, V. and Oexle, K. and Winkelmann, J.
Lancet Neurology 19 (11): 908-918. November 2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202 (10): 1445-1457. 15 November 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y. and Chen, F. and Fonseca, N.A. and He, Y. and Fujita, M. and Nakagawa, H. and Zhang, Z. and Brazma, A. and Creighton, C.J.
Nature Communications 11 (1): 736. 5 February 2020

Sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma.
Zirngibl, F. and Flemmig, C. and Lang, P. and Künkele, A. and Eggert, A. and Schulte, J.H. and Deubzer, H.E.
Children 7 (11): 198. 28 October 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
bioRxiv : 2020.01.23.916627. 24 January 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Sanchez-Bailon, M.P. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Popp, O. and Mertins, P. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
Cell Reports 33 (13): 108533. 29 December 2020

Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development.
van der Vorst, E.P.C. and Daissormont, I. and Aslani, M. and Seijkens, T. and Wijnands, E. and Lutgens, E. and Duchene, J. and Santovito, D. and Döring, Y. and Halvorsen, B. and Aukrust, P. and Weber, C. and Höpken, U.E. and Biessen, E.A.L.
Thrombosis and Haemostasis 120 (2): 344-347. February 2020

2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.
Abdulhay, N.J. and Fiorini, C. and Verboon, J.M. and Ludwig, L.S. and Ulirsch, J.C. and Zieger, B. and Lareau, C.A. and Mi, X. and Roy, A. and Obeng, E.A. and Erlacher, M. and Gupta, N. and Gabriel, S.B. and Ebert, B.L. and Niemeyer, C.M. and Khoriaty, R.N. and Ancliff, P. and Gazda, H.T. and Wlodarski, M.W. and Sankaran, V.G.
Journal of Experimental Medicine 216 (5): 1050-1060. 6 May 2019

C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice.
Ackermann, T. and Hartleben, G. and Müller, C. and Mastrobuoni, G. and Groth, M. and Sterken, B.A. and Zaini, M.A. and Youssef, S.A. and Zuidhof, H.R. and Krauss, S.R. and Kortman, G. and de Haan, G. and de Bruin, A. and Wang, Z.Q. and Platzer, M. and Kempa, S. and Calkhoven, C.F.
Communications Biology 2 : 208. 14 June 2019

Pressurized intraperitoneal aerosol chemotherapy and its effect on gastric-cancer-derived peritoneal metastases: an overview.
Alberto, M. and Brandl, A. and Garg, P.K. and Gül-Klein, S. and Dahlmann, M. and Stein, U. and Rau, B.
Clinical and Experimental Metastasis 36 (1): 1-14. February 2019

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.
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Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry.
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Saffron: The golden spice with therapeutic properties on digestive diseases.
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Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
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In contrast to Western diet, a plant-based, high-fat, low-sugar diet does not exacerbate retinal endothelial injury in streptozotocin-induced diabetes.
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The anti-amyloid compound DO1 decreases plaque pathology and neuroinflammation-related expression changes in 5xFAD transgenic mice.
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The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
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WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
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bioRxiv : 713925. 24 July 2019

Crowdfunded whole-genome sequencing of the celebrity cat Lil BUB identifies causal mutations for her osteopetrosis and polydactyly.
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Time-resolved DNA release from an O-antigen specific Salmonella bacteriophage with a contractile tail.
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Isolation and long-term cultivation of mouse alveolar macrophages.
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SaTAnn quantifies translation on the functionally heterogeneous transcriptome.
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bioRxiv : 608794. 14 April 2019

Ribo-seQC: comprehensive analysis of cytoplasmic and organellar ribosome profiling data.
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bioRxiv : 601468. 8 April 2019

DDX3 depletion selectively represses translation of structured mRNAs.
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Multi-platform discovery of haplotype-resolved structural variation in human genomes.
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Nature Communications 10 (1): 1784. 16 April 2019

Comparing agent‐based delivery of DNA and PNA forced intercalation (FIT) probes for multicolor mRNA imaging.
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Molecular recording of mammalian embryogenesis.
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Nature 570 (7759): 77-82. 6 June 2019

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
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Current and future treatment strategies for rhabdomyosarcoma.
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Frontiers in Oncology 9 : 1458. 20 December 2019

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
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bioRxiv : 758680. 6 September 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
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Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca2+ channel.
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bioRxiv : 741637. 20 August 2019

Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in amyotrophic lateral sclerosis.
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Cell Reports 27 (13): 3818-3831. 25 June 2019

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
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A Phase I/II first-line study of R-CHOP plus B-cell receptor/NF-κB-double-targeting to molecularly assess therapy response.
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International Journal of Hematologic Oncology 8 (4): IJH20. 19 December 2019

Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation.
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PRISMA: Protein Interaction Screen on Peptide Matrix reveals interaction footprints and modifications- dependent interactome of intrinsically disordered C/EBPb.
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Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma.
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Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
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Genotoxic stress-induced senescence.
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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
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Nature Neuroscience 22 (10): 1731-1742. October 2019

The role of Wnt and R-spondin in the stomach during health and disease.
Fischer, A.S. and Sigal, M.
Biomedicines 7 (2): 44. 19 June 2019

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
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Nature Immunology 20 (5): 546-558. May 2019

The transcription factor Hey and nuclear lamins specify and maintain cell identity.
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Circular RNAs in clear cell renal cell carcinoma: their microarray-based identification, analytical validation, and potential use in a clinico-genomic model to improve prognostic accuracy.
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Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency.
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Editorial: critical issues in lymphoma management.
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The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.
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Deep neural networks for interpreting RNA binding protein target preferences.
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bioRxiv : 518191. 11 January 2019

HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
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Cellular senescence: defining a path forward.
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sgRNA sequence motifs blocking efficient CRISPR/Cas9-mediated gene editing.
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Cell Reports 26 (5): 1098-1103. 29 January 2019

BCR-dependent lineage plasticity in mature B cells.
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Science 363 (6428): 748-753. 15 February 2019

Circulating MACC1 transcripts in glioblastoma patients predict prognosis and treatment response.
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Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.
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Cancer Letters 445 : 24-33. 31 March 2019

GOPHER: Generator Of Probes for capture Hi-C Experiments at high Resolution.
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BMC Genomics 20 (1): 40. 14 January 2019

Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment.
Haremaki, T. and Metzger, J.J. and Rito, T. and Ozair, M.Z. and Etoc, F. and Brivanlou, A.H.
Nature Biotechnology 37 (10): 1198-1208. October 2019

Structural features of tight-junction proteins.
Heinemann, U. and Schuetz, A.
International Journal of Molecular Sciences 20 (23): 6020. 29 November 2019

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M. and Ali, S. and Gonzalez, R.C. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Garcia, H.D. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
bioRxiv : 2019.12.20.875807. 20 December 2019

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J. and Hill, U. and Förster, S. and Zimmermann, K. and Malchin, V. and Kühl, A.A. and Stein, U. and Vieth, M. and Birchmeier, W. and Leutz, A.
Life Science Alliance 2 (1): e201800173. February 2019

Codon bias confers stability to human mRNAs.
Hia, F. and Yang, S.F. and Shichino, Y. and Yoshinaga, M. and Murakawa, Y. and Vandenbon, A. and Fukao, A. and Fujiwara, T. and Landthaler, M. and Natsume, T. and Adachi, S. and Iwasaki, S. and Takeuchi, O.
EMBO Reports 20 (11): e48220. 5 November 2019

Codon bias confers stability to mRNAs via ILF2 in humans.
Hia, F. and Yang, S.F. and Shichino, Y. and Yoshinaga, M. and Murakawa, Y. and Vandenbon, A. and Fukao, A. and Fujiwara, T. and Landthaler, M. and Natsume, T. and Adachi, S. and Iwasaki, S. and Takeuchi, O.
bioRxiv : 585992. 4 April 2019

RNA tomography for spatially resolved transcriptomics (Tomo-seq).
Holler, K. and Junker, J.P.
Methods in Molecular Biology 1920 : 129-141. 2019

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
Horwitz, S. and O'Connor, O.A. and Pro, B. and Illidge, T. and Fanale, M. and Advani, R. and Bartlett, N.L. and Christensen, J.H. and Morschhauser, F. and Domingo-Domenech, E. and Rossi, G. and Kim, W.S. and Feldman, T. and Lennard, A. and Belada, D. and Illés, A. and Tobinai, K. and Tsukasaki, K. and Yeh, S.P. and Shustov, A. and Hüttmann, A. and Savage, K.J. and Yuen, S. and Iyer, S. and Zinzani, P.L. and Hua, Z. and Little, M. and Rao, S. and Woolery, J. and Manley, T. and Trümper, L.
Lancet 393 (10168): 229-240. 19 January 2019

Genetics of intellectual disability in consanguineous families.
Hu, H. and Kahrizi, K. and Musante, L. and Fattahi, Z. and Herwig, R. and Hosseini, M. and Oppitz, C. and Abedini, S.S. and Suckow, V. and Larti, F. and Beheshtian, M. and Lipkowitz, B. and Akhtarkhavari, T. and Mehvari, S. and Otto, S. and Mohseni, M. and Arzhangi, S. and Jamali, P. and Mojahedi, F. and Taghdiri, M. and Papari, E. and Soltani Banavandi, M.J. and Akbari, S. and Tonekaboni, S.H. and Dehghani, H. and Ebrahimpour, M.R. and Bader, I. and Davarnia, B. and Cohen, M. and Khodaei, H. and Albrecht, B. and Azimi, S. and Zirn, B. and Bastami, M. and Wieczorek, D. and Bahrami, G. and Keleman, K. and Vahid, L.N. and Tzschach, A. and Gärtner, J. and Gillessen-Kaesbach, G. and Varaghchi, J.R. and Timmermann, B. and Pourfatemi, F. and Jankhah, A. and Chen, W. and Nikuei, P. and Kalscheuer, V.M. and Oladnabi, M. and Wienker, T.F. and Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 24 (7): 1027-1039. July 2019

Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5 (6): 351-364. June 2019

SURF1 mutations causative of Leigh syndrome impair human neurogenesis.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Juettner, R. and Zink, A. and Mlody, B. and Glazar, P. and Secker, C. and Ciptasari, U.H. and Stenzel, W. and Hahn, T. and Diecke, S. and Priller, J. and Gotthardt, M. and Kuehn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
bioRxiv : 551390. 20 February 2019

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Joshi, K. and de Massy, M.R. and Ismail, M. and Reading, J.L. and Uddin, I. and Woolston, A. and Hatipoglu, E. and Oakes, T. and Rosenthal, R. and Peacock, T. and Ronel, T. and Noursadeghi, M. and Turati, V. and Furness, A.J.S. and Georgiou, A. and Wong, Y.N.S. and Ben Aissa, A. and Sunderland, M.W. and Jamal-Hanjani, M. and Veeriah, S. and Birkbak, N.J. and Wilson, G.A. and Hiley, C.T. and Ghorani, E. and Guerra-Assunção, J.A. and Herrero, J. and Enver, T. and Hadrup, S.R. and Hackshaw, A. and Peggs, K.S. and McGranahan, N. and Swanton, C. and Quezada, S.A. and Chain, B.
Nature Medicine 25 (10): 1549-1559. October 2019

Detouring the roadblocks in gene expression.
Junker, J.P.
Nature Reviews Molecular Cell Biology 20 (4): 197. April 2019

Immunhistochemische Analyse von Bcl-2, nukleärem S100A4, MITF und Ki67 zur Risikostratifizierung von Melanomen im Frühstadium - ein kombinierter immunhistochemischer Score.
Jurmeister, P. and Bockmayr, M. and Treese, C. and Stein, U. and Lenze, D. and Jöhrens, K. and Friedling, F. and Dietel, M. and Klauschen, F. and Marsch, W. and Fiedler, E. and von Laffert, M.
Journal der Deutschen Dermatologischen Gesellschaft 17 (8): 800-809. August 2019

Immunohistochemical analysis of Bcl-2, nuclear S100A4, MITF and Ki67 for risk stratification of early-stage melanoma - a combined IHC score for melanoma risk stratification.
Jurmeister, P. and Bockmayr, M. and Treese, C. and Stein, U. and Lenze, D. and Jöhrens, K. and Friedling, F. and Dietel, M. and Klauschen, F. and Marsch, W. and Fiedler, E. and von Laffert, M.
Journal der Deutschen Dermatologischen Gesellschaft 17 (8): 800-808. August 2019

Cytotoxic effects of rabbit anti-thymocyte globulin preparations on primary human thymic epithelial cells.
Kaebisch, E.M. and Cho, M.Y. and Oh, Y.S. and Olfe, L.I. and Szyska, M. and Becker, S.C. and Reinke, P. and Volk, H.D. and Gillissen, B. and Bullinger, L. and Thiel, A. and Na, I.K.
Transplantation 103 (11): 2234-2244. November 2019

Nanocapsule induced morphology and migration changes in single cell layers quantified with digital holographic microscopy.
Kaiser, M. and Pohl, L. and Ketelhut, S. and Kastl, L. and Gorzelanny, C. and Götte, M. and Schnekenburger, J. and Goycoolea, F.M. and Kemper, B.
In: SPIE BiOS 2019, 2-7 Feb 2019, San Francisco, CA, USA. 4 March 2019

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
Karabacak Calviello, A. and Hirsekorn, A. and Wurmus, R. and Yusuf, D. and Ohler, U.
Genome Biology 20 (1): 42. 21 February 2019

Recruitment of histone methyltransferase Ehmt1 to Foxp3 TSDR counteracts differentiation of induced regulatory T cells.
Karl, M. and Sommer, C. and Gabriel, C.H. and Hecklau, K. and Venzke, M. and Hennig, A.F. and Radbruch, A. and Selbach, M. and Baumgrass, R.
Journal of Molecular Biology 431 (19): 3606-3625. 6 September 2019

Systems biology approach to study cancer metabolism.
Kempa, S. and Royla, N.
In: Encyclopedia of Cancer. Elsevier / Academic Press, 426-428. ISBN 978-0-12-812485-7 2019

Quantitative phase imaging-based concepts for the analysis of global morphology changes in confluent cell layers.
Kemper, B. and Pohl, L. and Kaiser, M. and Doepker, E. and Schnekenburger, J. and Ketelhut, S.
In: SPIE BiOS 2019, 2-7 Feb 2019, San Francisco, CA, USA. 4 March 2019

Label-free detection of global morphology changes in confluent cell layers utilizing quantitative phase imaging with digital holographic microscopy.
Kemper, B. and Pohl, L. and Kaiser, M. and Döpker, E. and Schnekenburger, J. and Ketelhut, S.
In: European Conferences on Biomedical Optics 2019, 26-27 Jun 2019, Munich, Germany. 22 July 2019

Interferon-γ receptor signaling in dendritic cells restrains spontaneous proliferation of CD4(+) T cells in chronic lymphopenic mice.
Knop, L. and Frommer, C. and Stoycheva, D. and Deiser, K. and Kalinke, U. and Blankenstein, T. and Kammertoens, T. and Dunay, I.R. and Schüler, T.
Frontiers in Immunology 10 : 140. 7 February 2019

A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Milanovic, M. and Tufan, A.B. and Uyar, B. and Sun, W. and Schleich, K. and von Hoff, L. and Willenbrock, M. and Krahn, I. and Jungmann, S. and Hinz, M. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
bioRxiv : 2019.12.19.882225. 20 December 2019

Janggu: deep learning for genomics.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
bioRxiv : 700450. 16 July 2019

Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY.
Kretschmann, S. and Herda, S. and Bruns, H. and Russ, J. and van der Meijden, E.D. and Schlötzer-Schrehardt, U. and Griffioen, M. and Na, I.K. and Mackensen, A. and Kremer, A.N.
Journal of Clinical Investigation 129 (7): 2952-2963. 1 July 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. and Peng, S. and Klironomos, F. and Munschauer, M. and Kastelic, N. and Chakraborty, T. and Schoeler, K. and Derudder, E. and Martella, M. and Mastrobuoni, G. and Hernandez-Miranda, L.R. and Lahmann, I. and Kocks, C. and Birchmeier, C. and Kempa, S. and Quintanilla-Martinez de Fend, L. and Landthaler, M. and Rajewsky, N. and Rajewsky, K.
Genes & Development 33 : 23-24. 7 November 2019

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Lahmann, I. and Bröhl, D. and Zyrianova, T. and Isomura, A. and Czajkowski, M.T. and Kapoor, V. and Griger, J. and Ruffault, P.L. and Mademtzoglou, D. and Zammit, P.S. and Wunderlich, T. and Spuler, S. and Kühn, R. and Preibisch, S. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Genes & Development 33 (9-10): 524-535. 1 May 2019

Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking.
Lareau, C.A. and Ludwig, L.S. and Sankaran, V.G.
Blood Advances 3 (24): 4161-4165. 23 December 2019

Efficient and precise CRISPR/Cas9-mediated MECP2 modifications in human-induced pluripotent stem cells.
Le, T.T.H. and Tran, N.T. and Dao, T.M.L. and Nguyen, D.D. and Do, H.D. and Ha, T.L. and Kühn, R. and Nguyen, T.L. and Rajewsky, K. and Chu, V.T.
Frontiers in Genetics 10 : 625. July 2019

The dynamic nature of senescence in cancer.
Lee, S. and Schmitt, C.A.
Nature Cell Biology 21 (1): 94-101. January 2019

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.
Leisegang, M.S. and Gu, L. and Preussner, J. and Günther, S. and Hitzel, J. and Ratiu, C. and Weigert, A. and Chen, W. and Schwarz, E.C. and Looso, M. and Fork, C. and Brandes, R.P.
FEBS Letters 593 (5): 487-498. March 2019

Using SMOG 2 to simulate complex biomolecular assemblies.
Levi, M. and Bandarkar, P. and Yang, H. and Wang, A. and Mohanty, U. and Noel, J.K. and Whitford, P.C.
Methods in Molecular Biology 2022 : 129-151. 2019

Studying ribosome dynamics with simplified models.
Levi, M. and Noel, J.K. and Whitford, P.C.
Methods 162-163 : 128-140. 1 June 2019

Pathophysiological role of caveolae in hypertension.
Lian, X. and Matthaeus, C. and Kaßmann, M. and Daumke, O. and Gollasch, M.
Frontiers in Medicine 6 : 153. July 2019

Mapping the MHC class I spliced immunopeptidome of cancer cells.
Liepe, J. and Sidney, J. and Lorenz, F.K.M. and Sette, A. and Mishto, M.
Cancer Immunology Research 7 (1): 62-76. January 2019

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer.
Link, T. and Kuhlmann, J.D. and Kobelt, D. and Herrmann, P. and Vassileva, Y. and Kramer, M. and Frank, K. and Göckenjan, M. and Wimberger, P. and Stein, U.
Molecular Oncology 13 (5): 1268-1279. May 2019

Transcriptional states and chromatin accessibility underlying human erythropoiesis.
Ludwig, L.S. and Lareau, C.A. and Bao, E.L. and Nandakumar, S.K. and Muus, C. and Ulirsch, J.C. and Chowdhary, K. and Buenrostro, J.D. and Mohandas, N. and An, X. and Aryee, M.J. and Regev, A. and Sankaran, V.G.
Cell Reports 27 (11): 3228-3240. 11 June 2019

Lineage tracing in humans enabled by mitochondrial mutations and single-cell genomics.
Ludwig, L.S. and Lareau, C.A. and Ulirsch, J.C. and Christian, E. and Muus, C. and Li, L.H. and Pelka, K. and Ge, W. and Oren, Y. and Brack, A. and Law, T. and Rodman, C. and Chen, J.H. and Boland, G.M. and Hacohen, N. and Rozenblatt-Rosen, O. and Aryee, M.J. and Buenrostro, J.D. and Regev, A. and Sankaran, V.G.
Cell 176 (6): 1325-1339. 7 March 2019

Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma.
MacArthur, I.C. and Bei, Y. and Garcia, H.D. and Ortiz, M.V. and Toedling, J. and Klironomos, F. and Rolff, J. and Eggert, A. and Schulte, J.H. and Kentsis, A. and Henssen, A.G.
JCI Insight 4 (10): e127130. 16 May 2019

Genomic inversions and GOLGA core duplicons underlie disease instability at the 15q25 locus.
Maggiolini, F.A.M. and Cantsilieris, S. and D'Addabbo, P. and Manganelli, M. and Coe, B.P. and Dumont, B.L. and Sanders, A.D. and Pang, A.W.C. and Vollger, M.R. and Palumbo, O. and Palumbo, P. and Accadia, M. and Carella, M. and Eichler, E.E. and Antonacci, F.
PLoS Genetics 15 (3): e1008075. 27 March 2019

An integrated understanding of the molecular mechanisms how adipose tissue metabolism affects long-term body weight maintenance.
Mai, K. and Li, L. and Wiegand, S. and Brachs, M. and Leupelt, V. and Ernert, A. and Kühnen, P. and Hübner, N. and Robinson, P. and Chen, W. and Krude, H. and Spranger, J.
Diabetes 68 (1): 57-65. 1 January 2019

Structure-based screening of tetrazolylhydrazide inhibitors versus KDM4 histone demethylases.
Malecki, P.H. and Rueger, N. and Roatsch, M. and Krylova, O. and Link, A. and Jung, M. and Heinemann, U. and Weiss, M.S.
ChemMedChem 14 (21): 1828-1839. 6 November 2019

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1.
Marques, C. and Unterkircher, T. and Kroon, P. and Izzo, A. and Gargiulo, G. and Kling, E. and Schnell, O. and Nelander, S. and Wagner, E.F. and Bakiri, L. and Carro, M.S. and Squatrito, M.
bioRxiv : 834531. 7 November 2019

Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints.
Massip, F. and Laurent, M. and Brossas, C. and Fernández-Justel, J.M. and Gómez, M. and Prioleau, M.N. and Duret, L. and Picard, F.
Nucleic Acids Research 47 (10): 5114-5125. 4 June 2019

Targeting APLN/APLNR improves antiangiogenic efficiency and blunts proinvasive side effects of VEGFA/VEGFR2 blockade in glioblastoma.
Mastrella, G. and Hou, M. and Li, M. and Stoecklein, V.M. and Zdouc, N. and Volmar, M.N.M. and Miletic, H. and Reinhard, S. and Herold-Mende, C.C. and Kleber, S. and Eisenhut, K. and Gargiulo, G. and Synowitz, M. and Vescovi, A.L. and Harter, P.N. and Penninger, J.M. and Wagner, E. and Mittelbronn, M. and Bjerkvig, R. and Hambardzumyan, D. and Schüller, U. and Tonn, J.C. and Radke, J. and Glass, R. and Kälin, R.E.
Cancer Research 79 (9): 2298-2313. May 2019

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization.
Matthaeus, C. and Lian, X. and Kunz, S. and Lehmann, M. and Zhong, C. and Bernert, C. and Lahmann, I. and Müller, D.N. and Gollasch, M. and Daumke, O.
PLoS ONE 14 (10): e0223620. 10 October 2019

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake.
Matthäus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Alves Melo, A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
bioRxiv : 511709. 7 March 2019

A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs.
McCorkindale, A.L. and Wahle, P. and Werner, S. and Jungreis, I. and Menzel, P. and Shukla, C.J. and Abreu, R.L.P. and Irizarry, R.A. and Meyer, I.M. and Kellis, M. and Zinzen, R.P.
Development 146 (6): dev175265. 28 March 2019

Transcriptional dynamics of microRNAs and their targets during Drosophila neurogenesis.
Menzel, P. and McCorkindale, A.L. and Stefanov, S.R. and Zinzen, R.P. and Meyer, I.M.
RNA Biology 16 (1): 69-81. 20 January 2019

BIQ: A method for searching circular RNAs in transcriptome databases by indexing backsplice junctions.
Menzel, P. and Meyer, I.M.
bioRxiv : 556993. 25 February 2019

Mapping the lung.
Mildner, A. and Yona, S.
Science 363 (6432): 1154-1155. 15 March 2019

Characterization of mouse adult testicular macrophage populations by immunofluorescence imaging and flow cytometry.
Mossadegh-Keller, N. and Sieweke, M.H.
Bio-protocol 9 (5): e3178. 5 March 2019

A (3D-nuclear) space odyssey: making sense of Hi-C maps.
Mota-Gómez, I. and Lupiáñez, D.G.
Genes 10 (6): 415. 29 May 2019

A quantitative modular modeling approach reveals the consequences of different A20 feedback implementations for the NF-κB signaling dynamics.
Mothes, J. and Ipenberg, I. and Arslan, S.Ç. and Benary, U. and Scheidereit, C. and Wolf, J.
bioRxiv : 582767. 19 March 2019

The conserved histone chaperone LIN-53 links lifespan and healthspan regulation in C. elegans.
Muethel, S. and Uyar, B. and He, M. and Krause, A. and Vitrinel, B. and Bulut, S. and Vasiljevic, D. and Akalin, A. and Kempa, S. and Tursun, B.
bioRxiv : 539015. 2 February 2019

Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
Mugahid, D.A. and Sengul, T.G. and You, X. and Wang, Y. and Steil, L. and Bergmann, N. and Radke, M.H. and Ofenbauer, A. and Gesell-Salazar, M. and Balogh, A. and Kempa, S. and Tursun, B. and Robbins, C.T. and Völker, U. and Chen, W. and Nelson, L. and Gotthardt, M.
Scientific Reports 9 (1): 19976. 27 December 2019

Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N. and Wessels, H.H. and Lebedeva, S. and Sajek, M. and Ghanbari, M. and Garzia, A. and Munteanu, A. and Yusuf, D. and Farazi, T. and Hoell, J.I. and Akat, K.M. and Akalin, A. and Tuschl, T. and Ohler, U.
Nucleic Acids Research 47 (2): 570-581. 25 January 2019

The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans.
Müthel, S. and Uyar, B. and He, M. and Krause, A. and Vitrinel, B. and Bulut, S. and Vasiljevic, D. and Marchal, I. and Kempa, S. and Akalin, A. and Tursun, B.
Aging Cell 18 (6): e13012. December 2019

Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies.
Na, I.K. and Buckland, M. and Agostini, C. and Edgar, J.D.M. and Friman, V. and Michallet, M. and Sánchez-Ramón, S. and Scheibenbogen, C. and Quinti, I.
European Journal of Haematology 102 (6): 447-456. June 2019

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis.
Nandakumar, S.K. and McFarland, S.K. and Mateyka, L.M. and Lareau, C.A. and Ulirsch, J.C. and Ludwig, L.S. and Agarwal, G. and Engreitz, J.M. and Przychodzen, B. and McConkey, M. and Cowley, G.S. and Doench, J.G. and Maciejewski, J.P. and Ebert, B.L. and Root, D.E. and Sankaran, V.G.
eLife 8 : e44080. 9 May 2019

Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Nasri, M. and Mir, P. and Dannenmann, B. and Amend, D. and Skroblyn, T. and Xu, Y. and Schulze-Osthoff, K. and Klimiankou, M. and Welte, K. and Skokowa, J.
Blood Advances 3 (1): 63-71. 8 January 2019

SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling.
Niogret, C. and Birchmeier, W. and Guarda, G.
Frontiers in Immunology 10 : 2468. 25 October 2019

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C. and Miah, S.M.S. and Rota, G. and Fonta, N.P. and Wang, H. and Held, W. and Birchmeier, W. and Sexl, V. and Yang, W. and Vivier, E. and Ho, P.C. and Brossay, L. and Guarda, G.
Nature Communications 10 (1): 1444. 29 March 2019

Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes.
Noel, J.K. and Noé, F. and Daumke, O. and Mikhailov, A.S.
Biophysical Journal 117 (10): 1870-1891. 19 November 2019

Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes.
Noel, J.K. and Noé, F. and Daumke, O. and Mikhailov, A.S.
bioRxiv : 686873. 28 June 2019

First person - Marcel Nowak and Benjamin Suenkel.
Nowak, M. and Suenkel, B.
Journal of Cell Science 132 (17): jcs237297. September 2019

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Nowak, M. and Suenkel, B. and Porras, P. and Migotti, R. and Schmidt, F. and Kny, M. and Zhu, X. and Wanker, E.E. and Dittmar, G. and Fielitz, J. and Sommer, T.
Journal of Cell Science 132 (17): jcs233395. 6 September 2019

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T. and Zhou, X. and Kosla, J. and Adili, A. and Garcia Beccaria, M. and Kotsiliti, E. and Pfister, D. and Johlke, A.L. and Sinha, A. and Sankowski, R. and Schick, M. and Lewis, R. and Dokalis, N. and Seubert, B. and Höchst, B. and Inverso, D. and Heide, D. and Zhang, W. and Weihrich, P. and Manske, K. and Wohlleber, D. and Anton, M. and Hoellein, A. and Seleznik, G. and Bremer, J. and Bleul, S. and Augustin, H.G. and Scherer, F. and Koedel, U. and Weber, A. and Protzer, U. and Förster, R. and Wirth, T. and Aguzzi, A. and Meissner, F. and Prinz, M. and Baumann, B. and Höpken, U.E. and Knolle, P.A. and von Baumgarten, L. and Keller, U. and Heikenwalder, M.
Cancer Cell 36 (3): 250-267. 16 September 2019

Chloroplast cold-resistance is mediated by the acidic domain of the RNA binding protein CP31A.
Okuzaki, A. and Lehniger, M.K. and Muino, J.M. and Lenzen, B. and Rühe, Thilo and Leister, D. and Ohler, U. and Schmitz-Linneweber, C.
bioRxiv : 832337. 5 December 2019

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.
Ortiz, M.V. and Ahmed, S. and Burns, M. and Henssen, A.G. and Hollmann, T.J. and MacArthur, I. and Gunasekera, S. and Gaewsky, L. and Bradwin, G. and Ryan, J. and Letai, A. and He, Y. and Naranjo, A. and Chi, Y.Y. and LaQuaglia, M. and Heaton, T. and Cifani, P. and Dome, J.S. and Gadd, S. and Perlman, E. and Mullen, E. and Steen, H. and Kentsis, A.
JCI Insight 4 (15): e127098. 8 August 2019

Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer.
Penter, L. and Dietze, K. and Ritter, J. and Lammoglia Cobo, M.F. and Garmshausen, J. and Aigner, F. and Bullinger, L. and Hackstein, H. and Wienzek-Lischka, S. and Blankenstein, T. and Hummel, M. and Dornmair, K. and Hansmann, L.
OncoImmunology 8 (6): e1586409. 24 March 2019

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Petrova, V.N. and Sawatsky, B. and Han, A.X. and Laksono, B.M. and Walz, L. and Parker, E. and Pieper, K. and Anderson, C.A. and de Vries, R.D. and Lanzavecchia, A. and Kellam, P. and von Messling, V. and de Swart, R.L. and Russell, C.A.
Science Immunology 4 (41): eaay6125. 1 November 2019

Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L. and Chen, X. and Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

A fully phased accurate assembly of an individual human genome.
Porubsky, D. and Ebert, P. and Audano, P.A. and Vollger, M.R. and Harvey, W.T. and Munson, K.M. and Sorensen, M. and Sulovari, A. and Haukness, M. and Ghareghani, M. and Lansdorp, P.M. and Paten, B. and Devine, S.E. and Sanders, A.D. and Lee, C. and Chaisson, M.J.P. and Korbel, J.O. and Eichler, E.E. and Marschall, T.
bioRxiv : 855049. 26 November 2019

KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
Qi, X.T. and Li, Y.L. and Zhang, Y.Q. and Xu, T. and Lu, B. and Fang, L. and Gao, J.Q. and Yu, L.S. and Zhu, D.F. and Yang, B. and He, Q.J. and Ying, M.D.
Acta Pharmacologica Sinica 40 (4): 546-555. April 2019

The advent and rise of monoclonal antibodies.
Rajewsky, K.
Nature 575 (7781): 47-49. November 2019

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.
Rauschmeier, R. and Gustafsson, C. and Reinhardt, A. and A-Gonzalez, N. and Tortola, L. and Cansever, D. and Subramanian, S. and Taneja, R. and Rossner, M.J. and Sieweke, M.H. and Greter, M. and Månsson, R. and Busslinger, M. and Kreslavsky, T.
EMBO Journal 38 (19): e101233. 1 October 2019

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.
Rohwer, N. and Jumpertz, S. and Erdem, M. and Egners, A. and Warzecha, K.T. and Fragoulis, At. and Kühl, A.A. and Kramann, R. and Neuss, S. and Rudolph, I. and Endermann, T. and Zasada, C. and Apostolova, I. and Gerling, M. and Kempa, S. and Hughes, R. and Lewis, C.E. and Brenner, W. and Malinowski, M.B. and Stockmann, M. and Schomburg, L. and Faller, W. and Sansom, O.J. and Tacke, F. and Morkel, M. and Cramer, T.
Oncogene 38 (28): 5670-5685. 11 July 2019

Single cell tri-channel-processing reveals structural variation landscapes and complex rearrangement processes.
Sanders, A.D. and Meiers, S. and Ghareghani, M. and Porubsky, D. and Jeong, H. and van Vliet, M.A.C.C. and Rausch, T. and Richter-Pechańska, P. and Kunz, J.B. and Jenni, S. and Raeder, B. and Kinanen, V. and Zimmermann, J. and Benes, V. and Schrappe, M. and Mardin, B.R. and Kulozik, A. and Bornhauser, B. and Bourquin, J.P. and Marschall, T. and Korbel, J.O.
bioRxiv : 849604. 21 November 2019

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
Schoeler, K. and Aufschnaiter, A. and Messner, S. and Derudder, E. and Herzog, S. and Villunger, A. and Rajewsky, K. and Labi, V.
FEBS Journal 286 (18): 3566-3581. September 2019

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.
Schroeder, M.P. and Bastian, L. and Eckert, C. and Gökbuget, N. and James, A.R. and Ortiz Tanchez, J. and Schlee, C. and Isaakidis, K. and Häupl, B. and Baum, K. and Migueles Lozano, O.A. and Kouidri, K. and Pan, K.T. and Urlaub, H. and Schwartz, S. and Burmeister, T. and von Stackelberg, A. and Hoelzer, D. and Pfeiffer, H. and Rieger, M.A. and Göllner, S. and Oellerich, T. and Horstman, M. and Schrappe, M. and Wolf, J. and Kirschner-Schwabe, R. and Brüggemann, M. and Müller-Tidow, C. and Serve, H. and Neumann, M. and Baldus, C.D.
Scientific Reports 9 (1): 4188. 12 March 2019

SigsPack, a package for cancer mutational signatures.
Schumann, F. and Blanc, E. and Messerschmidt, C. and Blankenstein, T. and Busse, A. and Beule, D.
BMC Bioinformatics 20 (1): 450. 2 September 2019

The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D. and Formichetti, S. and Junker, J.P. and Falcke, M. and Rajewsky, N.
bioRxiv : 2019.12.23.887570. 26 December 2019

PCNA-mediated degradation of p21 coordinates the DNA damage response and cell cycle regulation in individual cells.
Sheng, C. and Mendler, I.H. and Rieke, S. and Snyder, P. and Jentsch, M. and Friedrich, D. and Drossel, B. and Loewer, A.
Cell Reports 27 (1): 48-58. 2 April 2019

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.
Simunovic, M. and Metzger, J.J. and Etoc, F. and Yoney, A. and Ruzo, A. and Martyn, I. and Croft, G. and You, D.S. and Brivanlou, A.H. and Siggia, E.D.
Nature Cell Biology 21 (7): 900-910. July 2019

A SEPT1-based scaffold is required for Golgi integrity and function.
Song, K. and Gras, C. and Capin, G. and Gimber, N. and Lehmann, M. and Mohd, S. and Puchkov, D. and Rödiger, M. and Wilhelmi, I. and Daumke, O. and Schmoranzer, J. and Schürmann, A. and Krauss, M.
Journal of Cell Science 132 (3): jcs225557. 1 February 2019

Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling, S.A. and Fiedler, P. and Lechner, M. and Pollithy, A. and Ehrenberg, S. and Schiefer, A.I. and Kenner, L. and Feuchtinger, A. and Kühn, R. and Swinerd, G. and Schmidt-Supprian, M. and Strobl, L.J. and Zimber-Strobl, U.
Blood 133 (24): 2597-2609. 13 June 2019

Partner-independent fusion gene detection by multiplexed CRISPR/Cas9 enrichment and long-read Nanopore sequencing.
Stangl, C. and de Blank, S. and Renkens, I. and Verbeek, T. and Valle-Inclan, J.E. and González, R.C. and Henssen, A.G. and van Roosmalen, M.J. and Stam, R.W. and Voest, E.E. and Kloosterman, W.P. and van Haaften, G. and Monroe, G.
bioRxiv : 807545. 22 October 2019

53BP1 supports immunoglobulin class switch recombination independently of its DNA double-strand break end protection function.
Sundaravinayagam, D. and Rahjouei, A. and Andreani, M. and Tupiņa, D. and Balasubramanian, S. and Saha, T. and Delgado-Benito, V. and Coralluzzo, V. and Daumke, O. and Di Virgilio, M.
Cell Reports 28 (6): 1389-1399. 6 August 2019

Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K. and Imami, K. and Rajewsky, N.
Nature Communications 10 (1): 4205. 16 September 2019

Enhancement of precise gene editing by the association of Cas9 with homologous recombination factors.
Tran, N.T. and Bashir, S. and Li, X. and Rossius, J. and Chu, V.T. and Rajewsky, K. and Kühn, R.
Frontiers in Genetics 10 : 365. 30 April 2019

Efficient CRISPR/Cas9-mediated gene knockin in mouse hematopoietic stem and progenitor cells.
Tran, N.T. and Sommermann, T. and Graf, R. and Trombke, J. and Pempe, J. and Petsch, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Cell Reports 28 (13): 3510-3522.e5. 24 September 2019

How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.
Turco, E. and Witt, M. and Abert, C. and Bock-Bierbaum, T. and Su, M.Y. and Trapannone, R. and Sztacho, M. and Danieli, A. and Shi, X. and Zaffagnini, G. and Gamper, A. and Schuschnig, M. and Fracchiolla, D. and Bernklau, D. and Romanov, J. and Hartl, M. and Hurley, J.H. and Daumke, O. and Martens, S.
Autophagy 15 (8): 1475-1477. August 2019

FIP200 claw domain binding to p62 promotes autophagosome formation at ubiquitin condensates.
Turco, E. and Witt, M. and Abert, C. and Bock-Bierbaum, T. and Su, M.Y. and Trapannone, R. and Sztacho, M. and Danieli, A. and Shi, X. and Zaffagnini, G. and Gamper, A. and Schuschnig, M. and Fracchiolla, D. and Bernklau, D. and Romanov, J. and Hartl, M. and Hurley, J.H. and Daumke, O. and Martens, S.
Molecular Cell 74 (2): 330-346. 18 April 2019

Interrogation of human hematopoiesis at single-cell and single-variant resolution.
Ulirsch, J.C. and Lareau, C.A. and Bao, E.L. and Ludwig, L.S. and Guo, M.H. and Benner, C. and Satpathy, A.T. and Kartha, V.K. and Salem, R.M. and Hirschhorn, J.N. and Finucane, H.K. and Aryee, M.J. and Buenrostro, J.D. and Sankaran, V.G.
Nature Genetics 51 (4): 683-693. April 2019

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C. and Vieira-Vieira, C.H. and Hick, T. and Wessels, H.H. and Figini, D. and Moschall, R. and Medenbach, J. and Ohler, U. and Granneman, S. and Selbach, M. and Beckmann, B.M.
Nature Communications 10 (1): 990. 1 March 2019

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Csaba, Z. and Verdonk, F. and Montané, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Baud, O. and Rowitch, D. and Miron, V. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
Brain 142 (12): 3806-3833. December 2019

Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury.
Vigolo, E. and Markó, L. and Hinze, C. and Müller, D.N. and Schmidt-Ullrich, R. and Schmidt-Ott, K.M.
Kidney International 95 (1): 108-122. January 2019

Applying synergy metrics to oncology combination screening data: agreements, disagreements and pitfalls.
Vlot, A.H.C. and Aniceto, N. and Menden, M.P. and Ulrich-Merzenich, G. and Bender, A.
Drug Discovery Today 24 (12): 2286-2298. December 2019

A novel allele for inducible Cre expression in germinal center B cells.
Weber, T. and Seagal, J. and Winkler, W. and Wirtz, T. and Chu, V.T. and Rajewsky, K.
European Journal of Immunology 49 (1): 192-194. January 2019

Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
Wei, X. and Zhang, L. and Zhou, Z. and Kwon, O.J. and Zhang, Y. and Nguyen, H. and Dumpit, R. and True, L. and Nelson, P. and Dong, B. and Xue, W. and Birchmeier, W. and Taketo, M.M. and Xu, F. and Creighton, C.J. and Ittmann, M.M. and Xin, L.
Cell Stem Cell 24 (5): 753-768. 2 May 2019

Splicing factor Rbm10 facilitates heterochromatin assembly in fission yeast.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
bioRxiv : 518936. 11 January 2019

Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H. and Lebedeva, S. and Hirsekorn, A. and Wurmus, R. and Akalin, A. and Mukherjee, N. and Ohler, U.
Nature Communications 10 (1): 1626. 9 April 2019

Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma (NVUC).
Weyerer, V. and Weisser, R. and Moskalev, E.A. and Haller, F. and Stoehr, R. and Eckstein, M. and Zinnall, U. and Gaisa, N.T. and Compérat, E. and Perren, A. and Keck, B. and Allory, Y. and Kristiansen, G. and Wullich, B. and Agaimy, A. and Hartmann, A. and Bertz, S.
Histopathology 75 (6): 865-875. December 2019

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L’hernault, A. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Chunguang, L. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
bioRxiv : 603654. 9 April 2019

High salt inhibits tumor growth by enhancing anti-tumor immunity.
Willebrand, R. and Hamad, I. and Van Zeebroeck, L. and Kiss, M. and Bruderek, K. and Geuzens, A. and Swinnen, D. and Côrte-Real, B.F. and Markó, L. and Lebegge, E. and Laoui, D. and Kemna, J. and Kammertoens, T. and Brandau, S. and Van Ginderachter, J.A. and Kleinewietfeld, M.
Frontiers in Immunology 10 : 1141. 4 June 2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B. and Hewitt, S.L. and Heltemes-Harris, L.M. and Mandal, M. and Johnson, K. and Rajewsky, K. and Koralov, S.B. and Clark, M.R. and Farrar, M.A. and Skok, J.A.
Nature Communications 10 (1): 4768. 18 October 2019

Dosis und Wirkung in der Toxikologie: die Haber'sche Regel und Ableitungen.
Wunderlich, V.
BIOspektrum 25 (5): 584-585. September 2019

Die Kenntnis der Krebskrankheit aus historischer Perspektive: Das beispiellose Werk des Berliner Arztes Jacob Wolff (1861–1938).
Wunderlich, V.
Acta Historica Leopoldina 74 : 221-247. 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Bosse, J. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
bioRxiv : 566992. 4 March 2019

Epigenetic co-deregulation of EZH2/TET1 is a senescence-countering, actionable vulnerability in triple-negative breast cancer.
Yu, Y. and Qi, J. and Xiong, J. and Jiang, L. and Cui, D. and He, J. and Chen, P. and Li, L. and Wu, C. and Ma, T. and Shao, S. and Wang, J. and Yu, D. and Zhou, B. and Huang, D. and Schmitt, C.A. and Tao, R.
Theranostics 9 (3): 761-777. 24 January 2019

Efficient gene editing of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S. and Bashir, S. and Stumm, J. and Kühn, R.
Methods in Molecular Biology 1961 : 137-151. 2019

Integrated phosphoproteome and transcriptome analysis reveals Chlamydia-induced epithelial-to-mesenchymal transition in host cells.
Zadora, P.K. and Chumduri, C. and Imami, K. and Berger, H. and Mi, Y. and Selbach, M. and Meyer, T.F. and Gurumurthy, R.K.
Cell Reports 26 (5): 1286-1302. 29 January 2019

Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: the DACHS study.
Zaimenko, I. and Jaeger, C. and Brenner, H. and Chang-Claude, J. and Hoffmeister, M. and Grötzinger, C. and Detjen, K. and Burock, S. and Schmitt, C.A. and Stein, U. and Lisec, J.
International Journal of Cancer 145 (1): 221-231. 1 July 2019

Delayed allogeneic skin graft rejection in CD26-deficient mice.
Zhao, X. and Zhang, K. and Daniel, P. and Wisbrun, N. and Fuchs, H. and Fan, H.
Cellular and Molecular Immunology 16 (6): 557-567. June 2019

A novel predictor tool of biochemical recurrence after radical prostatectomy based on a five-microRNA tissue signature.
Zhao, Z. and Weickmann, S. and Jung, M. and Lein, M. and Kilic, E. and Stephan, C. and Erbersdobler, A. and Fendler, A. and Jung, K.
Cancers 11 (10): 1603. 21 October 2019

The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer.
Zhu, Q. and Fang, L. and Heuberger, J. and Kranz, A. and Schipper, J. and Scheckenbach, K. and Oliveira Vidal, R. and Sunaga-Franze, D.Y. and Müller, M. and Wulf-Goldenberg, A. and Sauer, S. and Birchmeier, W.
Cell Reports 26 (2): 415-428. 8 January 2019

The importance of developing therapies targeting the biological spectrum of metastatic disease.
Zijlstra, A. and Von Lersner, A. and Yu, D. and Borrello, L. and Oudin, M. and Kang, Y. and Sahai, E. and Fingleton, B. and Stein, U. and Cox, T.R. and Price, J.T. and Kato, Y. and Welm, A.L. and Aguirre-Ghiso, J.A.
Clinical and Experimental Metastasis 36 (4): 305-309. August 2019

The translational landscape of the human heart.
van Heesch, S. and Witte, F. and Schneider-Lunitz, V. and Schulz, J.F. and Adami, E. and Faber, A. and Kirchner, M. and Maatz, H. and Blachut, S. and Sandmann, C.L. and Kanda, M. and Worth, C.L. and Schafer, S. and Calviello, L. and Merriott, R. and Patone, G. and Hummel, O. and Wyler, E. and Obermayer, B. and Mücke, M. and Lindberg, E.L. and Trnka, F. and Memczak, S. and Schilling, M. and Felkin, L.E. and Barton, P.J.R. and Quaife, N.M. and Vanezis, K. and Diecke, S. and Mukai, M. and Mah, N. and Oh, S.J. and Kurtz, A. and Schramm, C. and Schwinge, D. and Sebode, M. and Harakalova, M. and Asselbergs, F.W. and Vink, A. and de Weger, R.A. and Viswanathan, S. and Widjaja, A.A. and Gärtner-Rommel, A. and Milting, H. and Dos Remedios, C. and Knosalla, C. and Mertins, P. and Landthaler, M. and Vingron, M. and Linke, W.A. and Seidman, J.G. and Seidman, C.E. and Rajewsky, N. and Ohler, U. and Cook, S.A. and Hubner, N.
Cell 178 (1): 242-260. 27 June 2019

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L. and Kärgel, E. and Franke, V. and McShane, E. and Schulz-Beiss, K.W. and Patone, G. and Schleussner, N. and Kolesnichenko, M. and Hübner, N. and Daumke, O. and Selbach, M. and Akalin, A. and Mathas, S. and Scheidereit, C.
Blood 133 (13): 1489-1494. 28 March 2019

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.
Çakmak-Görür, N. and Radke, J. and Rhein, S. and Schumann, E. and Willimsky, G. and Heppner, F.L. and Blankenstein, T. and Pezzutto, A.
Leukemia 33 (4): 1039-1043. April 2019

2018

Computational pan-genomics: status, promises and challenges.

Briefings in Bioinformatics 19 (1): 118-135. January 2018

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.
Arends, C.M. and Galan-Sousa, J. and Hoyer, K. and Chan, W. and Jäger, M. and Yoshida, K. and Seemann, R. and Noerenberg, D. and Waldhueter, N. and Fleischer-Notter, H. and Christen, F. and Schmitt, C.A. and Dörken, B. and Pelzer, U. and Sinn, M. and Zemojtel, T. and Ogawa, S. and Märdian, S. and Schreiber, A. and Kunitz, A. and Krüger, U. and Bullinger, L. and Mylonas, E. and Frick, M. and Damm, F.
Leukemia 32 (9): 1908-1919. September 2018

SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K. and Kranz, A. and Fohgrub, J. and Jolly, A. and Bledau, A.S. and Di Virgilio, M. and Lesche, M. and Dahl, A. and Höfer, T. and Stewart, A.F. and Waskow, C.
Blood 131 (12): 1311-1324. 22 March 2018

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.
Arnhold, V. and Schmelz, K. and Proba, J. and Winkler, A. and Wünschel, J. and Toedling, J. and Deubzer, H.E. and Künkele, A. and Eggert, A. and Schulte, J.H. and Hundsdoerfer, P.
Oncotarget 9 (2): 2304-2319. 2018

A comparative analysis of human bone marrow-resident and peripheral memory B cells.
Becker, S.C. and Szyska, M. and Mensen, A. and Hellwig, K. and Otto, R. and Olfe, L. and Volk, H.D. and Dörner, T. and Dörken, B. and Scheibenbogen, C. and Schröder, J. and Hocke, A.C. and Na, I.K.
Journal of Allergy and Clinical Immunology 141 (5): 1911-1913. May 2018

Information flow in a mammalian signal transduction pathway.
Benary, M. and Nolis, I. and Blüthgen, N. and Loewer, A.
In: Information- and Communication Theory in Molecular Biology. Lecture Notes in Bioengineering . Springer, Cham, Switzerland, 101-114. ISBN 978-3-319-54728-2 2018

The c-Myc/miR17-92/PTEN axis tunes PI3K activity to control expression of recombination activating genes in early B cell development.
Benhamou, D. and Labi, V. and Getahun, A. and Benchetrit, E. and Dowery, R. and Rajewsky, K. and Cambier, J.C. and Melamed, D.
Frontiers in Immunology 9 : 2715. November 2018

Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues.
Benndorf, R. and Gilmont, R.R. and Hirano, S. and Ransom, R.F. and Jungblut, P.R. and Bommer, M. and Goldman, J.E. and Welsh, M.J.
Cell Stress & Chaperones 23 (5): 813-826. September 2018

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Berndt, N. and Egners, A. and Mastrobuoni, G. and Vvedenskaya, O. and Fragoulis, A. and Dugourd, A. and Bulik, S. and Pietzke, M. and Bielow, C. and van Gassel, R. and Olde Damink, S. and Erdem, M. and Saez-Rodriguez, J. and Holzhütter, H.G. and Kempa, S. and Cramer, T.
bioRxiv : 275040. 5 March 2018

CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J. and Kieback, E. and Marino, S.F. and Oden, F. and Westermann, J. and Chmielewski, M. and Abken, H. and Uckert, W. and Höpken, U.E. and Rehm, A.
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Eichelbaum, K. and Sadewasser, A. and Wang, X. and Husic, I. and Paki, K. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
bioRxiv : 438176. 8 October 2018

Mechanisms of targeting the MDM2-p53-FOXM1 axis in well-differentiated intestinal neuroendocrine tumors.
Briest, F. and Grass, I. and Sedding, D. and Moebs, M. and Christen, F. and Benecke, J. and Fuchs, K. and Mende, S. and Kaemmerer, D. and Saenger, J. and Kunze, A. and Geisler, C. and Freitag, H. and Lewens, F. and Worpenberg, L. and Iwaszkiewicz, S. and Siegmund, B. and Walther, W. and Hummel, M. and Grabowski, P.
Neuroendocrinology 107 (1): 1-23. July 2018

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial.
Burock, S. and Daum, S. and Keilholz, U. and Neumann, K. and Walther, W. and Stein, U.
BMC Cancer 18 (1): 297. 15 March 2018

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.
Bégay, V. and Baumeier, C. and Zimmermann, K. and Heuser, A. and Leutz, A.
Scientific Reports 8 (1): 8417. 30 May 2018

Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types.
Calabrese, C. and Davidson, N.R. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Demircioğlu, D. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, L. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
bioRxiv : 183889. 12 March 2018

Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses.
Choi, I.K. and Wang, Z. and Ke, Q. and Hong, M. and Qian, Y. and Zhao, X. and Liu, Y. and Kim, H.J. and Ritz, J. and Cantor, H. and Rajewsky, K. and Wucherpfennig, K.W. and Zhang, B.
Proceedings of the National Academy of Sciences of the United States of America 115 (4): E686-E695. January 2018

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. and Obenaus, M. and Miskey, C. and Ivics, Z. and Izsvák, Z. and Uckert, W. and Bunse, M.
Human Gene Therapy 29 (5): 569-584. May 2018

Genome-wide analysis of barrett's adenocarcinoma. a first step towards identifying patients at risk and developing therapeutic paths.
Dai, Y. and Wang, Q. and Gonzalez Lopez, A. and Anders, M. and Malfertheiner, P. and Vieth, M. and Kemmner, W.
Translational Oncology 11 (1): 116-124. February 2018

Randomized, phase 3 trial of inotuzumab ozogamicin plus rituximab versus chemotherapy plus rituximab for relapsed/refractory aggressive B-cell non-Hodgkin lymphoma.
Dang, N.H. and Ogura, M. and Castaigne, S. and Fayad, L.E. and Jerkeman, M. and Radford, J. and Pezzutto, A. and Bondarenko, I. and Stewart, D.A. and Shnaidman, M. and Sullivan, S. and Vandendries, E. and Tobinai, K. and Ramchandren, R. and Hamlin, P.A. and Giné, E. and Ando, K.
British Journal of Haematology 182 (4): 583-586. August 2018

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Decaesteker, B. and Denecker, G. and Van Neste, C. and Dolman, E.M. and Van Loocke, W. and Gartlgruber, M. and Nunes, C. and De Vloed, F. and Depuydt, P. and Verboom, K. and Rombaut, D. and Loontiens, S. and De Wyn, J. and Kholosy, W.M. and Koopmans, B. and Essing, A.H.W. and Herrmann, C. and Dreidax, D. and Durinck, K. and Deforce, D. and van Nieuwerburgh, F. and Henssen, A. and Versteeg, R. and Boeva, V. and Schleiermacher, G. and van Nes, J. and Mestdagh, P. and Vanhauwaert, S. and Schulte, J.H. and Westermann, F. and Molenaar, J.J. and De Preter, K. and Speleman, F.
Nature Communications 9 (1): 4866. 19 November 2018

The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
Delgado-Benito, V. and Rosen, D.B. and Wang, Q. and Gazumyan, A. and Pai, J.A. and Oliveira, T.Y. and Sundaravinayagam, D. and Zhang, W. and Andreani, M. and Keller, L. and Kieffer-Kwon, K.R. and Pękowska, A. and Jung, S. and Driesner, M. and Subbotin, R.I. and Casellas, R. and Chait, B.T. and Nussenzweig, M.C. and Di Virgilio, M.
Molecular Cell 72 (4): 636-649. 15 November 2018

Stage-specific metabolic features of differentiating neurons: implications for toxicant sensitivity.
Delp, J. and Gutbier, S. and Cerff, M. and Zasada, C. and Niedenführ, S. and Zhao, L. and Smirnova, L. and Hartung, T. and Borlinghaus, H. and Schreiber, F. and Bergemann, J. and Gätgens, J. and Beyss, M. and Azzouzi, S. and Waldmann, T. and Kempa, S. and Nöh, K. and Leist, M.
Toxicology and Applied Pharmacology 354 : 64-80. 1 September 2018

Structural changes of TasA in biofilm formation of Bacillus subtilis.
Diehl, A. and Roske, Y. and Ball, L. and Chowdhury, A. and Hiller, M. and Molière, N. and Kramer, R. and Stöppler, D. and Worth, C.L. and Schlegel, B. and Leidert, M. and Cremer, N. and Erdmann, N. and Lopez, D. and Stephanowitz, H. and Krause, E. and van Rossum, B.J. and Schmieder, P. and Heinemann, U. and Turgay, K. and Akbey, Ü. and Oschkinat, H.
Proceedings of the National Academy of Sciences of the United States of America 115 (13): 3237-3242. 27 March 2018

omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data.
Drewe-Boss, P. and Wessels, H.H. and Ohler, U.
Genome Biology 19 : 183. 1 November 2018

Spatial transcriptomics of C. elegans males and hermaphrodites identifies novel fertility genes.
Ebbing, A. and Vertesy, A. and Betist, M. and Spanjaard, B. and Junker, J.P. and van Oudenaarden, A. and Berezikov, E. and Korswagen, H.
bioRxiv : 348201. 15 June 2018

Spatial transcriptomics of C. elegans males and hermaphrodites identifies sex-specific differences in gene expression patterns.
Ebbing, A. and Vértesy, Á. and Betist, M.C. and Spanjaard, B. and Junker, J.P. and Berezikov, E. and van Oudenaarden, A. and Korswagen, H.C.
Developmental Cell 47 (6): 801-813. 17 December 2018

Struktur und Funktion des mechanochemischen Motorproteins Dynamin.
Faelber, K. and Daumke, O.
BIOspektrum 24 (5): 481-483. September 2018

A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.
Fang, G.M. and Chamiolo, J. and Kankowski, S. and Hövelmann, F. and Friedrich, D. and Löwer, A. and Meier, J.C. and Seitz, O.
Chemical Science 9 (21): 4794-4800. 7 June 2018

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo.
Fecher, C. and Trovò, L. and Müller, S.A. and Snaidero, N. and Wettmarshausen, J. and Heink, S. and Ortiz, O. and Wagner, I. and Kühn, R. and Hartmann, J. and Karl, R.M. and Konnerth, A. and Korn, T. and Wurst, W. and Merkler, D. and Lichtenthaler, S.L. and Perocchi, F. and Misgeld, T.
bioRxiv : 403774. 29 August 2018

Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients.
Feldheim, J. and Kessler, A.F. and Schmitt, D. and Wilczek, L. and Linsenmann, T. and Dahlmann, M. and Monoranu, C.M. and Ernestus, R.I. and Hagemann, C. and Löhr, M.
OncoTargets and Therapy 11 : 8673-8684. 4 December 2018

Keratinocyte-specific ablation of protease-activated receptor-2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.
Francis, N. and Ayodele, B.A. and O'Brien-Simpson, N.M. and Birchmeier, W. and Pike, R.N. and Pagel, C.N. and Mackie, E.J.
Cellular Microbiology 20 (11): e12891. November 2018

Circular RNAs: a new class of biomarkers as a rising interest in laboratory medicine.
Franz, A. and Rabien, A. and Stephan, C. and Ralla, B. and Fuchs, S. and Jung, K. and Fendler, A.
Clinical Chemistry and Laboratory Medicine 56 (12): 1992-2003. December 2018

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations.
Fritsche-Guenther, R. and Zasada, C. and Mastrobuoni, G. and Royla, N. and Rainer, R. and Roßner, F. and Pietzke, M. and Klipp, E. and Sers, C. and Kempa, S.
Scientific Reports 8 (1): 9204. 15 June 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L. and Alvarez-Martinez, M. and Luisier, R. and Cox, L.S. and Sodenkamp, J. and Hosking, C. and Pérez-Mazliah, D. and Whicher, C. and Kannan, Y. and Potempa, K. and Wu, X. and Bhaw, L. and Wende, H. and Sieweke, M.H. and Elgar, G. and Wilson, M. and Briscoe, J. and Metzis, V. and Langhorne, J. and Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

A novel form of RNA double helix based on G·U and C·A(+) wobble base pairing.
Garg, A. and Heinemann, U.
RNA 24 (2): 209-218. February 2018

Next-generation in vivo modeling of human cancers.
Gargiulo, G.
Frontiers in Oncology 8 : 429. October 2018

Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.
Gavvovidis, I. and Leisegang, M. and Willimsky, G. and Miller, N.J. and Nghiem, P. and Blankenstein, T.
Clinical Cancer Research 24 (15): 3644-3655. August 2018

First genome-wide CNV mapping in FELIS CATUS using next generation sequencing data.
Genova, F. and Longeri, M. and Lyons, L.A. and Bagnato, A. and Strillacci, M.G.
BMC Genomics 19 (1): 895. 10 December 2018

Strand-seq enables reliable separation of long reads by chromosome via expectation maximization.
Ghareghani, M. and Porubskỳ, D. and Sanders, A.D. and Meiers, S. and Eichler, E.E. and Korbel, J.O. and Marschall, T.
Bioinformatics 34 (13): i115-i123. 1 July 2018

NKp46 receptor-mediated interferon-γ production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis.
Glasner, A. and Levi, A. and Enk, J. and Isaacson, B. and Viukov, S. and Orlanski, S. and Scope, A. and Neuman, T. and Enk, C.D. and Hanna, J.H. and Sexl, V. and Jonjic, S. and Seliger, B. and Zitvogel, L. and Mandelboim, O.
Immunity 48 (1): 107-119. 16 January 2018

Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity.
Graf, L. and Dick, A. and Sendker, F. and Barth, E. and Marz, M. and Daumke, O. and Kochs, G.
Journal of Biological Chemistry 293 (9): 3056-3072. 2 March 2018

Developmental and functional heterogeneity of monocytes.
Guilliams, M. and Mildner, A. and Yona, S.
Immunity 49 (4): 595-613. 16 October 2018

An intrinsic interferon program protects stem cells from viral infection.
Haas, S. and Trumpp, A.
Developmental Cell 44 (3): 279-280. 5 February 2018

Causes and consequences of hematopoietic stem cell heterogeneity.
Haas, S. and Trumpp, A. and Milsom, M.D.
Cell Stem Cell 22 (5): 627-638. 3 May 2018

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors.
Haghverdi, L. and Lun, A.T.L. and Morgan, M.D. and Marioni, J.C.
Nature Biotechnology 36 (5): 421-427. May 2018

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.
Hammer, Q. and Rückert, T. and Borst, E.M. and Dunst, J. and Haubner, A. and Durek, P. and Heinrich, F. and Gasparoni, G. and Babic, M. and Tomic, A. and Pietra, G. and Nienen, M. and Blau, I.W. and Hofmann, J. and Na, I.K. and Prinz, I. and Koenecke, C. and Hemmati, P. and Babel, N. and Arnold, R. and Walter, J. and Thurley, K. and Mashreghi, M.F. and Messerle, M. and Romagnani, C.
Nature Immunology 19 (5): 453-463. May 2018

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
Henssen, A.G. and Kentsis, A.
JCI Insight 3 (20): 123172. 18 October 2018

Construction of whole genomes from scaffolds using single cell strand-seq data.
Hills, M. and Falconer, E. and O’Neil, K. and Sanders, A.D. and Howe, K. and Guryev, V. and Lansdorp, P.M.
bioRxiv : 271510. 26 February 2018

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
Hinze, F. and Drewe-Boss, P. and Milek, M. and Ohler, U. and Landthaler, M. and Gotthardt, M.
RNA Biology 15 (3): 359-368. 4 March 2018

Unraveling the transcriptional regulation of TWIST1 in limb development.
Hirsch, N. and Eshel, R. and Bar Yaacov, R. and Shahar, T. and Shmulevich, F. and Dahan, I. and Levaot, N. and Kaplan, T. and Lupiáñez, D.G. and Birnbaum, R..
PLoS Genetics 14 (10): e1007738. 29 October 2018

Nontargeted identification of tracer incorporation in high-resolution mass spectrometry.
Hoffmann, F. and Jaeger, C. and Bhattacharya, A. and Schmitt, C.A. and Lisec, J.
Analytical Chemistry 90 (12): 7253-7260. 19 June 2018

Efficient non-viral gene delivery into human hematopoietic stem cells by minicircle Sleeping Beauty transposon vectors.
Holstein, M. and Mesa-Nuñez, C. and Miskey, C. and Almarza, E. and Poletti, V. and Schmeer, M. and Grueso, E. and Ordóñez Flores, J.C. and Kobelt, D. and Walther, W. and Aneja, M.K. and Geiger, J, and Bonig, H.B. and Izsvák, Z. and Schleef, M. and Rudolph, C. and Mavilio, F. and Bueren, J.A. and Guenechea, G. and Ivics, Z.
Molecular Therapy 26 (4): 1137-1153. 4 April 2018

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D. and Schön, C. and Loddenkemper, C. and Lohneis, P. and Kühl, A.A. and Sommermann, T. and Blankenstein, T. and Willimsky, G.
Blood 132 (9): 924-934. 30 August 2018

Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M. and Karabacak, A. and Glahs, A. and Kolundzic, E. and Hirsekorn, A. and Carda, A. and Tursun, B. and Zinzen, R.P. and Lacadie, S.A. and Ohler, U.
Nature Communications 9 (1): 4472. 26 October 2018

Microbiome and diseases: colorectal cancer.
Iftekhar, A. and Sperlich, A. and Janssen, K.P. and Sigal, M.
In: The Gut Microbiome in Health and Disease. Springer, Cham, 231-249. ISBN 978-3-319-90544-0 2018

Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K. and Milek, M. and Bogdanow, B. and Yasuda, T. and Kastelic, N. and Zauber, H. and Ishihama, Y. and Landthaler, M. and Selbach, M.
Molecular Cell 72 (1): 84-98. 4 October 2018

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: a comprehensive examination of the potential carriers for semiochemicals.
Iovinella, I. and McAfee, A. and Mastrobuoni, G. and Kempa, S. and Foster, L.J. and Pelosi, P. and Dani, F.R.
Journal of Proteomics 181 : 131-141. 15 June 2018

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: a comprehensive examination of the potential carriers for semiochemicals.
Iovinella, I. and McAfee, A. and Mastrobuoni, G. and Kempa, S. and Foster, L.J. and Pelosi, P. and Dani, F.R.
bioRxiv : 260539. 7 February 2018

Long noncoding RNA lISPR1 is required for S1P signaling and endothelial cell function.
Josipovic, I. and Pflueger, B. and Fork, C. and Vasconez, A.E. and Oo, J.A. and Hitzel, J. and Seredinski, S. and Gamen, E. and Heringdorf, D.M.Z. and Chen, W. and Looso, M. and Pullamsetti, S.S. and Brandes, R.P. and Leisegang, M.S.
Journal of Molecular and Cellular Cardiology 116 : 57-68. March 2018

Crystal structures of the single PDZ domains from GRASP65 and their interaction with the golgin GM130.
Jurk, C.M. and Roske, Y. and Heinemann, U.
Croatica Chemica Acta 91 (2): 255-264. June 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
Kabrani, E. and Chu, V.T. and Tasouri, E. and Sommermann, T. and Baßler, K. and Ulas, T. and Zenz, T. and Bullinger, L. and Schultze, J.L. and Rajewsky, K. and Sander, S.
Blood 132 (25): 2670-2683. 20 December 2018

The influence of capsaicin on the integrity of microvascular endothelial cell monolayers.
Kaiser, M. and Burek, M. and Britz, S. and Lankamp, F. and Ketelhut, S. and Kemper, B. and Förster, C. and Gorzelanny, C. and Goycoolea, F.M.
International Journal of Molecular Sciences 20 (1): 122. 30 December 2018

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets via protocol-specific bias modeling.
Karabacak Calviello, A. and Hirsekorn, A. and Wurmus, R. and Yusuf, D. and Ohler, U.
bioRxiv : 284364. 19 March 2018

Ribosome levels selectively regulate translation and lineage commitment in human hematopoiesis.
Khajuria, R.K. and Munschauer, M. and Ulirsch, J.C. and Fiorini, C. and Ludwig, L.S. and McFarland, S.K. and Abdulhay, N.J. and Specht, H. and Keshishian, H. and Mani, D.R. and Jovanovic, M. and Ellis, S.R. and Fulco, C.P. and Engreitz, J.M. and Schütz, S. and Lian, J. and Gripp, K.W. and Weinberg, O.K. and Pinkus, G.S. and Gehrke, L. and Regev, A. and Lander, E.S. and Gazda, H.T. and Lee, W.Y. and Panse, V.G. and Carr, S.A. and Sankaran, V.G.
Cell 173 (1): 90-103. 22 March 2018

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim, M. and Wende, H. and Walcher, J. and Kühnemund, J. and Cheret, C. and Kempa, S. and McShane, E. and Selbach, M. and Lewin, G.R. and Birchmeier, C.
Genes & Development 32 (9-10): 645-657. 10 May 2018

S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo.
Kleinwort, A. and Luehrs, F. and Heidecke, C.D. and Lipp, M. and Schulze, T.
International Journal of Molecular Sciences 19 (2): 391. 29 January 2018

Structural investigation of glycan recognition by the ERAD quality control lectin Yos9.
Kniss, A. and Kazemi, S. and Löhr, F. and Berger, M. and Rogov, V.V. and Güntert, P. and Sommer, T. and Jarosch, E. and Dötsch, V.
Journal of Biomolecular NMR 72 (1-2): 1-10. October 2018

Chain assembly and disassembly processes differently affect the conformational space of ubiquitin chains.
Kniss, A. and Schuetz, D. and Kazemi, S. and Pluska, L. and Spindler, P.E. and Rogov, V.V. and Husnjak, K. and Dikic, I. and Güntert, P. and Sommer, T. and Prisner, T.F. and Dötsch, V.
Structure 26 (2): 249-258. 6 February 2018

FACT sets a barrier for cell fate reprogramming in Caenorhabditis elegans and human cells.
Kolundzic, E. and Ofenbauer, A. and Bulut, S.I. and Uyar, B. and Baytek, G. and Sommermeier, A. and Seelk, S. and He, M. and Hirsekorn, A. and Vucicevic, D. and Akalin, A. and Diecke, S. and Lacadie, S.A. and Tursun, B.
Developmental Cell 46 (5): 611-626. 10 September 2018

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
Kragesteen, B.K. and Spielmann, M. and Paliou, C. and Heinrich, V. and Schöpflin, R. and Esposito, A. and Annunziatella, C. and Bianco, S. and Chiariello, A.M. and Jerković, I. and Harabula, I. and Guckelberger, P. and Pechstein, M. and Wittler, L. and Chan, Wi.L. and Franke, M. and Lupiáñez, D.G. and Kraft, K. and Timmermann, B. and Vingron, M. and Visel, A. and Nicodemi, M. and Mundlos, S. and Andrey, G.
Nature Genetics 50 (10): 1463-1473. October 2018

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas.
Kratzsch, T. and Kuhn, S.A. and Joedicke, A. and Hanisch, U.K. and Vajkoczy, P. and Hoffmann, J. and Fichtner, I.
Journal of Cancer Research and Clinical Oncology 144 (5): 809-819. May 2018

NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types.
Krieger, K. and Millar, S.E. and Mikuda, N. and Krahn, I. and Kloepper, J.E. and Bertolini, M. and Scheidereit, C. and Paus, R. and Schmidt-Ullrich, R.
Journal of Investigative Dermatology 138 (2): 256-264. February 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S. and Gohlke, U. and Broeker, N.K. and Roske, Y. and Heinemann, U. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140 (33): 10447-10455. 22 August 2018

Redundant regulation.
Lacadie, S.A. and Ohler, U.
Nature Ecology & Evolution 2 (3): 418-419. March 2018

Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates.
Langer, H.T. and Senden, J.M.G. and Gijsen, A.P. and Kempa, S. and van Loon, Luc J. C. and Spuler, S.
Frontiers in Physiology 9 : 1220. 31 August 2018

Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill.
Lin, X. and Noel, J.K. and Wang, Q. and Ma, J. and Onuchic, J.N.
Proceedings of the National Academy of Sciences of the United States of America 115 (34): E7905-E7913. 21 August 2018

Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J. and Noel, J.K. and Low, H.H.
Nature Communications 9 (1): 3345. 21 August 2018

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.
Löber, U. and Hobbs, M. and Dayaram, A. and Tsangaras, K. and Jones, K. and Alquezar-Planas, D.E. and Ishida, Y. and Meers, J. and Mayer, J. and Quedenau, C. and Chen, W. and Johnson, R.N. and Timms, P. and Young, P.R. and Roca, A.L. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 115 (34): 8609-8614. 21 August 2018

A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs.
McCorkindale, A.L. and Wahle, P. and Werner, S. and Jungreis, I. and Menzel, P. and Shukla, C.J. and Lopes Pereira Abreu, R. and Irizarry, Rafael and Meyer, I. and Kellis, Manolis and Zinzen, R.P.
bioRxiv : 483461. 27 December 2018

Synthetic embryology: controlling geometry to model early mammalian development.
Metzger, J.J. and Simunovic, M. and Brivanlou, A.H.
Current Opinion in Genetics & Development 52 : 86-91. October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N. and Kolesnichenko, M. and Beaudette, P. and Popp, O. and Uyar, B. and Sun, W. and Tufan, A.B. and Perder, B. and Akalin, A. and Chen, W. and Mertins, P. and Dittmar, G. and Hinz, M. and Scheidereit, C.
EMBO Journal 37 (24): e98658. 14 December 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

The Senescence-Stemness Alliance - a cancer-hijacked regeneration principle.
Milanovic, M. and Yu, Y. and Schmitt, C.A.
Trends in Cell Biology 28 (12): 1049-1061. December 2018

Systematic detection of poly(A)(+) RNA-interacting proteins and their differential binding.
Milek, M. and Landthaler, M.
Methods in Molecular Biology 1649 : 405-417. 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Small molecules co-targeting CKIα and the transcriptional kinases CDK7/9 control AML in preclinical models.
Minzel, W. and Venkatachalam, A. and Fink, A. and Hung, E. and Brachya, G. and Burstain, I. and Shaham, M. and Rivlin, A. and Omer, I. and Zinger, A. and Elias, S. and Winter, E. and Erdman, P.E. and Sullivan, R.W. and Fung, L. and Mercurio, F. and Li, D. and Vacca, J. and Kaushansky, N. and Shlush, L. and Oren, M. and Levine, R. and Pikarsky, E. and Snir-Alkalay, I. and Ben-Neriah, Y.
Cell 175 (1): 171-185.e25. 20 September 2018

Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response.
Morey, P. and Pfannkuch, L. and Pang, E. and Boccellato, F. and Sigal, M. and Imai-Matsushima, A. and Dyer, V. and Koch, M. and Mollenkopf, H.J. and Schlaermann, P. and Meyer, T.F.
Gastroenterology 154 (5): 1391-1404. April 2018

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.
Morgani, S.M. and Metzger, J.J. and Nichols, J. and Siggia, E.D. and Hadjantonakis, A.K.
eLife 7 : e32839. 7 February 2018

Testicular macrophages: guardians of fertility.
Mossadegh-Keller, Noushin and Sieweke, M.H.
Cellular Immunology 330 : 120-125. August 2018

Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N. and Wessels, H.H. and Lebedeva, S. and Sajek, M. and Ghanbari, M. and Garzia, A. and Munteanu, A. and Farazi, T. and Hoell, J.I. and Akat, K. and Tuschl, T. and Ohler, U.
bioRxiv : 295097. 10 April 2018

SSMART: Sequence-structure motif identification for RNA-binding proteins.
Munteanu, A. and Mukherjee, N. and Ohler, U.
Bioinformatics 34 (23): 3990-3998. 1 December 2018

SSMART: Sequence-structure motif identification for RNA-binding proteins.
Munteanu, A. and Mukherjee, N. and Ohler, U.
bioRxiv : 287953. 23 March 2018

Pan-class I  PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.
Müller, A. and Gillissen, B. and Richter, A. and Richter, A. and Chumduri, C. and Daniel, P.T. and Scholz, C.W.
Cell Death & Disease 9 (3): 384. 7 March 2018

Spatial organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Alp, K.M. and Giudice, G. and Heinrich, L.E. and Barth, C. and Eccles, R.L. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Wortmann, C. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Bakal, C. and Gingras, A.C. and Pertz, O. and Roth, F.P. and Colwill, K. and Pawson, T. and Petsalaki, E. and Rocks, O.
bioRxiv : 354316. 29 August 2018

Finding RNA structure in the unstructured RBPome.
Orenstein, Y. and Ohler, U. and Berger, B.
BMC Genomics 19 (1): 154. 20 February 2018

Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor.
Ortiz, M.V. and Ahmed, S. and Burns, M. and Henssen, A.G. and Hollmann, T.J. and MacArthur, I. and Gunasekera, S. and Gaewsky, L. and Bradwin, G. and Ryan, J. and Letai, A. and He, Y. and Naranjo, A. and Chi, Y.Y. and LaQuaglia, M. and Heaton, T. and Cifani, P. and Dome, J.S. and Gadd, S. and Perlman, El. and Mullen, E. and Steen, H. and Kentsis, A.
bioRxiv : 508754. 30 December 2018

Evolutionary plasticity in the innate immune function of Akirin.
Polanowska, J. and Chen, J.X. and Soulé, J. and Omi, S. and Belougne, J. and Taffoni, C. and Pujol, N. and Selbach, M. and Zugasti, O. and Ewbank, J.J.
PLoS Genetics 14 (7): e1007494. 23 July 2018

Ectopic transplastomic expression of a synthetic MatK gene leads to cotyledon-specific leaf variegation.
Qu, Y. and Legen, J. and Arndt, J. and Henkel, S. and Hoppe, G. and Thieme, C. and Ranzini, G. and Muino, J.M. and Weihe, A. and Ohler, U. and Weber, G. and Ostersetzer, O. and Schmitz-Linneweber, C.
Frontiers in Plant Science 9 : 1453. October 2018

MACC1 - the first decade of a key metastasis molecule from gene discovery to clinical translation.
Radhakrishnan, H. and Walther, W. and Zincke, F. and Kobelt, D. and Imbastari, F. and Erdem, M. and Kortüm, B. and Dahlmann, M. and Stein, U.
Cancer and Metastasis Reviews 37 (4): 805-820. December 2018

Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Nature 559 (7713): 211-216. July 2018

miR-9-5p in nephrectomy specimens is a potential predictor of primary resistance to first-line treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma.
Ralla, B. and Busch, J. and Flörcken, A. and Westermann, J. and Zhao, Z. and Kilic, E. and Weickmann, S. and Jung, M. and Fendler, A. and Jung, K.
Cancers 10 (9): 321. 10 September 2018

Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y. and Sabag, O. and Skversky, Y. and Spiro, A. and Steinberg, B. and Bernstein, D. and Wang, A. and Kieckhaefer, J. and Li, C. and Pikarsky, E. and Levin-Klein, R. and Goren, A. and Rajewsky, K. and Kaestner, K.H. and Cedar, H.
Nature Communications 9 (1): 2040. 23 May 2018

Quantifying multi-layered expression regulation in response to stress of the endoplasmic reticulum.
Rendleman, J. and Cheng, Z. and Maity, S. and Kastelic, N. and Munschauer, M. and Allgoewer, K. and Teo, G. and Zhang, Y.B. and Lei, A. and Parker, B. and Landthaler, M. and Freeberg, L. and Kuersten, S. and Choi, H. and Vogel, C.
bioRxiv : 308379. 25 April 2018

New insights into the cellular temporal response to proteostatic stress.
Rendleman, J. and Cheng, Z. and Maity, S. and Kastelic, N. and Munschauer, M. and Allgoewer, K. and Teo, G. and Zhang, Y.B.M. and Lei, A. and Parker, B. and Landthaler, M. and Freeberg, L. and Kuersten, S. and Choi, H. and Vogel, C.
eLife 7 : e39054. 12 October 2018

Confocal endomicroscopy in diagnosis of intestinal chronic graft-versus-host disease.
Rieger, K. and Günther, U. and Erben, U. and Kühl, A. and Loddenkemper, C. and Pezzutto, A. and Siegmund, B. and Bojarski, C.
Hematological Oncology 36 (1): 291-298. February 2018

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis.
Rohwer, N. and Jumpertz, S. and Erdem, M. and Egners, A. and Warzecha, K.T. and Fragoulis, A. and Kuehl, A.A. and Kramann, R. and Neuss, S. and Rudolph, I. and Endermann, T. and Zasada, C. and Apostolova, I. and Gerling, M. and Kempa, S. and Hughes, R. and Lewis, C.E. and Brenner, W. and Malinowski, M.B. and Stockmann, M. and Schomburg, L. and Faller, W. and Sansom, O.J. and Tacke, F. and Morkel, M. and Cramer, T.
bioRxiv : 273045. 28 February 2018

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo.
Rota, G. and Niogret, C. and Dang, A.T. and Barros, C.R. and Fonta, N.P. and Alfei, F. and Morgado, L. and Zehn, D. and Birchmeier, W. and Vivier, E. and Guarda, G.
Cell Reports 23 (1): 39-49. 3 April 2018

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M. and Gonzalez, E. and Teixeira da Costa, A.R. and Wask, L. and Gravenstein, I. and Pardo, M. and Pietzke, M. and Gurumurthy, R.K. and Angermann, J. and Laudeley, R. and Glage, S. and Meyer, M. and Chumduri, C. and Kempa, S. and Dinkel, K. and Unger, A. and Klebl, B. and Klos, A. and Meyer, T.F.
Cell Host & Microbe 23 (5): 661-671. 9 May 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Chromosomal instability during neurogenesis in Huntington's disease.
Ruzo, A. and Croft, G.F. and Metzger, J.J. and Galgoczi, S. and Gerber, L.J. and Pellegrini, C. and Wang, H. and Fenner, M. and Tse, S. and Marks, A. and Nchako, C. and Brivanlou, A.H.
Development 145 (2) January 2018

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Schleussner, N. and Merkel, O. and Costanza, M. and Liang, H.C. and Hummel, F. and Romagnani, C. and Durek, P. and Anagnostopoulos, I. and Hummel, M. and Jöhrens, K. and Niedobitek, A. and Griffin, P.R. and Piva, R. and Sczakiel, H.L. and Woessmann, W. and Damm-Welk, C. and Hinze, C. and Stoiber, D. and Gillissen, B. and Turner, S.D. and Kaergel, E. and von Hoff, L. and Grau, M. and Lenz, G. and Dörken, B. and Scheidereit, C. and Kenner, L. and Janz, M. and Mathas, S.
Leukemia 32 (9): 1994-2007. September 2018

Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons.
Schmidt, H. and Dickey, D.M. and Dumoulin, A. and Octave, M. and Robinson, J.W. and Kühn, R. and Feil, R. and Potter, L.R. and Rathjen, F.G.
Journal of Neuroscience 38 (45): 9768-9780. 7 November 2018

ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice.
Schmidt, K. and Keller, C. and Kühl, A.A. and Textor, A. and Seifert, U. and Blankenstein, T. and Willimsky, G. and Kloetzel, P.M.
Cancer Research 78 (12): 3243-3254. June 2018

UnSASPing senescence: unmasking tumor suppression?
Schmitt, C.A.
Cancer Cell 34 (1): 6-8. 9 July 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K. and Tröger, J. and Eldahshan, A. and Zühlke, K. and Abdul Azeez, K.R. and Elkins, J.M. and Neuenschwander, M. and Oder, A. and Elkewedi, M.M.H. and Jaksch, S. and Andrae, K. and Li, J. and Fernandes, J. and Müller, P.M. and Grunwald, S. and Marino, S.F. and Vukićević, T. and Eichhorst, J. and Wiesner, B. and Weber, M. and Kapiloff, M. and Rocks, O. and Daumke, O. and Wieland, T. and Knapp, S. and von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J. and Mah, N. and Neuenschwander, M. and Kischka, T. and Ratei, R. and Schlag, P.M. and Castaños-Vélez, E. and Fichtner, I. and Tunn, P.U. and Denkert, C. and Klaas, O. and Berdel, W.E. and von Kries, J.P. and Makalowski, W. and Andrade-Navarro, M.A. and Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Serresi, M. and Siteur, B. and Hulsman, D. and Company, C. and Schmitt, M.J. and Lieftink, C. and Morris, B. and Cesaroni, M. and Proost, N. and Beijersbergen, R.L. and van Lohuizen, M. and Gargiulo, G.
Journal of Experimental Medicine 215 (12): 3115. 3 December 2018

Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars.
Spanjaard, B. and Hu, B. and Mitic, N. and Olivares-Chauvet, P. and Janjuha, S. and Ninov, N. and Junker, J.P.
Nature Biotechnology 36 (5): 469-473. May 2018

Structural variation in the 3D genome.
Spielmann, M. and Lupiáñez, D.G. and Mundlos, S.
Nature Reviews Genetics 19 (7): 453-467. July 2018

Deciphering the universe of RNA structures and trans RNA-RNA interactions of transcriptomes in vivo: from experimental protocols to computational analyses.
Stefanov, S.R. and Meyer, I.M.
In: Systems Biology. RNA Technologies . Springer, Cham, 173-216. ISBN 978-3-319-92966-8 2018

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
Strasen, J. and Sarma, U. and Jentsch, M. and Bohn, S. and Sheng, C. and Horbelt, D. and Knaus, P. and Legewie, S. and Loewer, A.
Molecular Systems Biology 14 (1): e7733. 25 January 2018

Metabolic labeling of newly synthesized RNA with 4sU to in parallel assess RNA transcription and decay.
Sun, W. and Chen, W.
Methods in Molecular Biology 1720 : 25-34. 2018

Pervasive allele-specific regulation on RNA decay in hybrid mice.
Sun, W. and Gao, Q. and Schaefke, B. and Hu, Y. and Chen, W.
Life Science Alliance 1 (2): e201800052. May 2018

A transgenic dual-luciferase reporter mouse for longitudinal and functional monitoring of T cells in vivo.
Szyska, M. and Herda, S. and Althoff, S. and Heimann, A. and Russ, J. and D'Abundo, D. and Dang, T.M. and Durieux, I. and Dörken, B. and Blankenstein, T. and Na, I.K.
Cancer Immunology Research 6 (1): 110-120. January 2018

Evaluating uncertainty in signaling networks using logical modeling.
Thobe, K. and Kuznia, C. and Sers, C. and Siebert, H.
Frontiers in Physiology 9 : 1335. October 2018

MYCN-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma.
Tjaden, B. and Baum, K. and Marquardt, V. and Simon, M. and Trajkovic-Arsic, M. and Kouril, T. and Siebers, B. and Lisec, J. and Siveke, J.T. and Schulte, J.H. and Benary, U. and Remke, M. and Wolf, J. and Schramm, A.
bioRxiv : 423756. 25 September 2018

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.
Turajlic, S. and Xu, H. and Litchfield, K. and Rowan, A. and Horswell, S. and Chambers, T. and O'Brien, T. and Lopez, J.I. and Watkins, T.B.K. and Nicol, D. and Stares, M. and Challacombe, B. and Hazell, S. and Chandra, A. and Mitchell, T.J. and Au, L. and Eichler-Jonsson, C. and Jabbar, F. and Soultati, A. and Chowdhury, S. and Rudman, S. and Lynch, J. and Fernando, A. and Stamp, G. and Nye, E. and Stewart, A. and Xing, W. and Smith, J.C. and Escudero, M. and Huffman, A. and Matthews, N. and Elgar, G. and Phillimore, B. and Costa, M. and Begum, S. and Ward, S. and Salm, M. and Boeing, S. and Fisher, R. and Spain, L. and Navas, C. and Grönroos, E. and Hobor, S. and Sharma, S. and Aurangzeb, I. and Lall, S. and Polson, A. and Varia, M. and Horsfield, C. and Fotiadis, N. and Pickering, L. and Schwarz, R.F. and Silva, B. and Herrero, J. and Luscombe, N.M. and Jamal-Hanjani, M. and Rosenthal, R. and Birkbak, N.J. and Wilson, G.A. and Pipek, O. and Ribli, D. and Krzystanek, M. and Csabai, I. and Szallasi, Z. and Gore, M. and McGranahan, N. and Van Loo, P. and Campbell, P. and Larkin, J. and Swanton, C.
Cell 173 (3): 595-610. 19 April 2018

The genetic landscape of diamond-blackfan anemia.
Ulirsch, J.C. and Verboon, J.M. and Kazerounian, S. and Guo, M.H. and Yuan, D. and Ludwig, L.S. and Handsaker, R.E. and Abdulhay, N.J. and Fiorini, C. and Genovese, G. and Lim, E.T. and Cheng, A. and Cummings, B.B. and Chao, K.R. and Beggs, A.H. and Genetti, C.A. and Sieff, C.A. and Newburger, P.E. and Niewiadomska, E. and Matysiak, M. and Vlachos, A. and Lipton, J.M. and Atsidaftos, E. and Glader, B. and Narla, A. and Gleizes, P.E. and O'Donohue, M.F. and Montel-Lehry, N. and Amor, D.J. and McCarroll, S.A. and O'Donnell-Luria, A.H. and Gupta, N. and Gabriel, S.B. and MacArthur, D.G. and Lander, E.S. and Lek, M. and Da Costa, L. and Nathan, D.G. and Korostelev, A.A. and Do, R. and Sankaran, V.G. and Gazda, H.T.
American Journal of Human Genetics 103 (6): 930-947. 6 December 2018

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C. and Vieira-Vieira, C.H. and Hick, T. and Wessels, H.H. and Figini, D. and Moschall, R. and Medenbach, J. and Ohler, U. and Granneman, S. and Selbach, M. and Beckmann, B.M.
bioRxiv : 333385. 30 May 2018

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Verdonk, F. and Montane, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Miron, V. and Rowitch, D. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
bioRxiv : 334359. 31 May 2018

Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching.
Wagner, A.S. and Politi, A.Z. and Ast, A. and Bravo-Rodriguez, K. and Baum, K. and Buntru, A. and Strempel, N.U. and Brusendorf, L. and Hänig, C. and Boeddrich, A. and Plassmann, S. and Klockmeier, K. and Ramirez-Anguita, J.M. and Sanchez-Garcia, E. and Wolf, J. and Wanker, E.E.
Journal of Molecular Biology 430 (12): 1725-1744. 8 June 2018

Phylogenetic quantification of intratumor heterogeneity.
Watkins, T.B.K. and Schwarz, R.F.
Cold Spring Harbor Perspectives in Medicine 8 (4): a028316. April 2018

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities.
Weber, A.N.R. and Cardona Gloria, Y. and Çınar, Ö. and Reinhardt, H.C. and Pezzutto, A. and Wolz, O.O.
Cancer Immunology Immunotherapy 67 (11): 1797-1807. November 2018

Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model.
Weiser, C. and Petkova, M.V. and Rengstl, B. and Döring, C. and von Laer, D. and Hartmann, S. and Küppers, R. and Hansmann, M.L. and Newrzela, S.
Oncotarget 9 (22): 15942-15951. 23 March 2018

Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
Weng, Q. and Wang, J. and Wang, J. and Wang, J. and Sattar, F. and Zhang, Z. and Zheng, J. and Xu, Z. and Zhao, M. and Liu, X. and Yang, L. and Hao, G. and Fang, L. and Lu, Q.R. and Yang, B. and He, Q.
Cell Death & Disease 9 (2): 251. 14 February 2018

Global identification of functional microRNA::mRNA interactions in Drosophila.
Wessels, H.H. and Lebedeva, S. and Hirsekorn, A. and Mukherjee, N. and Ohler, U.
bioRxiv : 395335. 22 August 2018

Discovering novel hydrolases from hot environments.
Wohlgemuth, R. and Littlechild, J. and Monti, D. and Schnorr, K. and van Rossum, T. and Siebers, B. and Menzel, P. and Kublanov, I.V. and Rike, A.G. and Skretas, G. and Szabo, Z. and Peng, X. and Young, M.J.
Biotechnology Advances 36 (8): 2077-2100. December 2018

Cumulative regulatory potential of clustered methyl-arginine protein modifications.
Woodsmith, J. and Casado-Medrano, V. and Benlasfer, N. and Eccles, R.L. and Hutten, S. and Heine, C. and Thormann, V. and Abou-Ajram, C. and Rocks, O. and Dormann, D. and Stelzl, U.
bioRxiv : 289041. 26 March 2018

Interaction modulation through arrays of clustered methyl-arginine protein modifications.
Woodsmith, J. and Casado-Medrano, V. and Benlasfer, N. and Eccles, R.L. and Hutten, S. and Heine, C.L. and Thormann, V. and Abou-Ajram, C. and Rocks, O. and Dormann, D. and Stelzl, U.
Life Science Alliance 1 (5): e201800178. October 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Good things come in threes.
Yona, S. and Mildner, A.
Science Immunology 3 (30): eaav5545. 7 December 2018

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Yoney, A. and Etoc, F. and Ruzo, A. and Carroll, T. and Metzger, J.J. and Martyn, I. and Li, S. and Kirst, C. and Siggia, E.D. and Brivanlou, A.H.
eLife 7 : e3827. 13 November 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y. and Schleich, K. and Yue, B. and Ji, S. and Lohneis, P. and Kemper, K. and Silvis, M.S. and Qutob, N. and van Rooijen, E. and Werner-Klein, M. and Li, L. and Dhawan, D. and Meierjohann, S. and Reimann, M. and Elkahloun, A. and Treitschke, S. and Dörken, B. and Speck, C. and Mallette, F.A. and Zon, L.I. and Holmen, S.L. and Peeper, D.S. and Samuels, Y. and Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Picky: a simple online PRM and SRM method designer for targeted proteomics.
Zauber, H. and Kirchner, M. and Selbach, M.
Nature Methods 15 (3): 156-157. 28 February 2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A. and Huang, J. and Györfi, A.H. and Matei, A.E. and Trinh-Minh, T. and Xu, X. and Li, Y.N. and Chen, C.W. and Lin, J. and Dees, C. and Beyer, C. and Gelse, K. and Zhang, Z.Y. and Bergmann, C. and Ramming, A. and Birchmeier, W. and Distler, O. and Schett, G. and Distler, J.H.W.
Nature Communications 9 (1): 3259. 14 August 2018

Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype.
Zinnall, U. and Weyerer, V. and Compérat, E. and Camparo, P. and Gaisa, N.T. and Knuechel-Clarke, R. and Perren, A. and Lugli, A. and Toma, M. and Baretton, G. and Kristiansen, G. and Wirtz, R.M. and Cheng, L. and Wullich, B. and Stoehr, R. and Hartmann, A. and Bertz, S.
Human Pathology 80 : 55-64. October 2018

2017

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Nature 545 (7655): 446-451. 25 May 2017

Chlamydia trachomatis prevents apoptosis via activation of PDPK1-MYC and enhanced mitochondrial binding of hexokinase II.
Al-Zeer, M.A. and Xavier, A. and Abu Lubad, M. and Sigulla, J. and Kessler, M. and Hurwitz, R. and Meyer, T.F.
EBioMedicine 23 : 100-110. September 2017

Cell fixation and preservation for droplet-based single-cell transcriptomics.
Alles, J. and Karaiskos, N. and Praktiknjo, S. and Grosswendt, S. and Wahle, P. and Ruffault, P.L. and Ayoub, S. and Schreyer, L. and Boltengagen, A. and Birchmeier, C. and Zinzen, R. and Kocks, C. and Rajewsky, N.
bioRxiv : 099473. 13 April 2017

Cell fixation and preservation for droplet-based single-cell transcriptomics.
Alles, J. and Karaiskos, N. and Praktiknjo, S.D. and Grosswendt, S. and Wahle, P. and Ruffault, P.L. and Ayoub, S. and Schreyer, L. and Boltengagen, A. and Birchmeier, C. and Zinzen, R. and Kocks, C. and Rajewsky, N.
BMC Biology 15 (1): 44. 19 May 2017

The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.
Anders, K. and Kershaw, O. and Larue, L. and Gruber, A.D. and Blankenstein, T.
International Journal of Cancer 141 (12): 2551-2561. 15 December 2017

RNA-bioinformatics: tools, services and databases for the analysis of RNA-based regulation.
Backofen, R. and Engelhardt, J. and Erxleben, A. and Fallmann, J. and Grüning, B. and Ohler, U. and Rajewsky, N. and Stadler, P.F.
Journal of Biotechnology 261 : 76-84. 10 November 2017

Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis.
Baddack-Werncke, U. and Busch-Dienstfertig, M. and Gonzalez-Rodriguez, S. and Maddila, S.C. and Grobe, J. and Lipp, M. and Stein, C. and Mueller, G.
Journal of Neuroinflammation 14 (1): 30. 6 February 2017

Subsequent malignancies among long-term survivors of Hodgkin lymphoma and non-Hodgkin lymphoma: a pooled analysis of German cancer registry data (1990-2012).
Baras, N. and Dahm, S. and Haberland, J. and Janz, M. and Emrich, K. and Kraywinkel, K. and Salama, A.
British Journal of Haematology 177 (2): 226-242. April 2017

Enhanced precision and efficiency.
Bashir, S. and Kühn, R.
Nature Biomedical Engineering 1 (11): 856-857. November 2017

Pancreatic cancer models for translational research.
Behrens, D. and Walther, W. and Fichtner, I.
Pharmacology & Therapeutics 173 : 146-158. May 2017

Mathematical modelling of promoter occupancies in MYC-dependent gene regulation.
Benary, U. and Wolf, E. and Wolf, J.
Genomics and Computational Biology 3 (2): e54. 2017

On mass ambiguities in high-resolution shotgun lipidomics.
Bielow, C. and Mastrobuoni, G. and Orioli, M. and Kempa, S.
Analytical Chemistry 89 (5): 2986-2994. 7 March 2017

Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C. and Werner, A. and John, D. and Boeckel, J.-N. and Melissari, M.-T. and Grote, P. and Glaser, S.F. and Demolli, S. and Uchida, S. and Michalik, K.M. and Meder, B. and Katus, H.A. and Haas, J. and Chen, W. and Pullamsetti, S.S. and Seeger, W. and Zeiher, A.M. and Dimmeler, S. and Zehendner, C.M.
Circulation Research 121 (4): 368-375. 4 August 2017

A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
Boege, Y. and Malehmir, M. and Healy, M.E. and Bettermann, K. and Lorentzen, A. and Vucur, M. and Ahuja, A.K. and Böhm, F. and Mertens, J.C. and Shimizu, Y. and Frick, L. and Remouchamps, C. and Mutreja, K. and Kähne, T. and Sundaravinayagam, D. and Wolf, M.J. and Rehrauer, H. and Koppe, C. and Speicher, T. and Padrissa-Altés, S. and Maire, R. and Schattenberg, J.M. and Jeong, J.S. and Liu, Lei and Zwirner, S. and Boger, R. and Hüser, N. and Davis, R.J. and Müllhaupt, B. and Moch, H. and Schulze-Bergkamen, H. and Clavien, P.A. and Werner, S. and Borsig, L. and Luther, S.A. and Jost, P.J. and Weinlich, R. and Unger, K. and Behrens, A. and Hillert, L. and Dillon, C. and Di Virgilio, M. and Wallach, D. and Dejardin, E. and Zender, L. and Naumann, M. and Walczak, H. and Green, D.R. and Lopes, M. and Lavrik, I. and Luedde, T. and Heikenwalder, M. and Weber, A.
Cancer Cell 32 (3): 342-359. 11 September 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, M.R. and Simon, M.M. and Ingham, N.J. and Greenaway, S. and Santos, L. and Cater, H. and Taylor, S. and Mason, J. and Kurbatova, N. and Pearson, S. and Bower, L.R. and Clary, D.A. and Meziane, H. and Reilly, P. and Minowa, O. and Kelsey, L. and Tocchini-Valentini, G.P. and Gao, X. and Bradley, A. and Skarnes, W.C. and Moore, M. and Beaudet, A.L. and Justice, M.J. and Seavitt, J. and Dickinson, M.E. and Wurst, W. and Hrabe de Angelis, M. and Herault, Y. and Wakana, S. and Nutter, L.M.J. and Flenniken, A.M. and McKerlie, C. and Murray, S.A. and Svenson, K.L. and Braun, R.E. and West, D.B. and Lloyd, K.C.K. and Adams, D.J. and White, J. and Karp, N. and Flicek, P. and Smedley, D. and Meehan, T.F. and Parkinson, H.E. and Teboul, L.M. and Wells, S. and Steel, K.P. and Mallon, A.M. and Brown, S.D.M.
Nature Communications 8 (1): 886. 12 October 2017

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.
Brocks, D. and Schmidt, C.R. and Daskalakis, M. and Jang, H.S. and Shah, N.M. and Li, D. and Li, J. and Zhang, B. and Hou, Y. and Laudato, S. and Lipka, D.B. and Schott, J. and Bierhoff, H. and Assenov, Y. and Helf, M. and Ressnerova, A. and Islam, M.S. and Lindroth, A.M. and Haas, S. and Essers, M. and Imbusch, C.D. and Brors, B. and Oehme, I. and Witt, O. and Lübbert, M. and Mallm, J.P. and Rippe, K. and Will, R. and Weichenhan, D. and Stoecklin, G. and Gerhäuser, C. and Oakes, C.C. and Wang, T. and Plass, C.
Nature Genetics 49 (7): 1052-1060. July 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

Assessing the gene regulatory landscape in 1,188 human tumors.
Calabrese, C. and Lehmann, K.V. and Urban, L. and Liu, F. and Erkek, S. and Fonseca, N. and Kahles, A. and Kilpinen-Barrett, L.H. and Markowski, J. and Waszak, S. and Korbel, J. and Zhang, Z. and Brazma, A. and Raetsch, G. and Schwarz, R. and Stegle, O.
bioRxiv : 225441. 29 November 2017

Beyond read-counts: Ribo-seq data analysis to understand the functions of the transcriptome.
Calviello, L. and Ohler, U.
Trends in Genetics 33 (10): 728-744. October 2017

Identification of a novel benzimidazole pyrazolone scaffold that inhibits KDM4 lysine demethylases and reduces proliferation of prostate cancer cells.
Carter, D.M. and Specker, E. and Przygodda, J. and Neuenschwander, M. and von Kries, J.P. and Heinemann, U. and Nazaré, M. and Gohlke, U.
SLAS Discovery 22 (7): 801-812. 1 August 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N. and Naumann, H. and Ruzittu, S. and Mah, N. and Pongrac, I.M. and Cozzitorto, C. and Hommel, A. and Andrade-Navarro, M.A. and Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
Chen, X. and Poncette, L. and Blankenstein, T.
Journal of Experimental Medicine 214 (11): 3417-3433. 6 November 2017

Endothelial NF-κB blockade abrogates ANCA-induced GN.
Choi, M. and Schreiber, A. and Eulenberg-Gustavus, C. and Scheidereit, C. and Kamps, J. and Kettritz, R.
Journal of the American Society of Nephrology 28 (11): 3191-3204. November 2017

CRISPR/Cas9-mediated in vitro mutagenesis in GC-like B cells.
Chu, V.T. and Graf, R. and Rajewsky, K.
Methods in Molecular Biology 1623 : 135-145. 2017

C/EBP-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of B cells.
Cirovic, B. and Schönheit, J. and Kowenz-Leutz, E. and Ivanovska, J. and Klement, C. and Pronina, N. and Bégay, V. and Leutz, A.
Stem Cell Reports 14 (8): 346-359. 14 February 2017

Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Heinemann, U. and Wahl, M.C. and Risse, T.
Physical Chemistry Chemical Physics 19 (31): 20723-20734. 9 August 2017

Internal dynamics of the 3-pyrroline-N-oxide ring in spin-labeled proteins.
Consentius, P. and Loll, B. and Gohlke, U. and Alings, C. and Müller, C. and Müller, R. and Teutloff, C. and Heinemann, U. and Kaupp, M. and Wahl, M.C. and Risse, T.
Journal of Physical Chemistry Letters 8 (6): 1113-1117. 16 March 2017

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.
Cui, H. and Bansal, V. and Grunert, M. and Malecova, B. and Dall Agnese, A. and Latella, L. and Gatto, S. and Ryan, T. and Schulz, K. and Chen, W. and Dorn, C. and Puri, P.L. and Sperling, S.R.
PLoS ONE 12 (6): e0179464. 13 June 2017

Control of gene editing by manipulation of DNA repair mechanisms.
Danner, E. and Bashir, S. and Yumlu, S. and Wurst, W. and Wefers, B. and Kühn, R.
Mammalian Genome 28 (7-8): 262-274. August 2017

Mitochondrial homeostasis: How do dimers of mitofusins mediate mitochondrial fusion?
Daumke, O. and Roux, A.
Current Biology 27 (9): R353-R356. 8 May 2017

Channeling of branched flow in weakly scattering anisotropic media.
Degueldre, H. and Metzger, J.J. and Schultheis, E. and Fleischmann, R.
Physical Review Letters 118 (2): 024301. 13 January 2017

The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure, F.R. and Royla, N. and Herold, S. and Kalb, J. and Walz, S. and Ade, C.P. and Mastrobuoni, G. and Vanselow, J.T. and Schlosser, A. and Wolf, E. and Kempa, S. and Eilers, M.
EMBO Journal 36 (13): 1854-1868. 3 July 2017

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ.
Dittmar, G. and Perez-Hernandez, D. and Kowenz-Leutz, E. and Kirchner, M. and Kahlert, G. and Wesolowski, R. and Baum, K. and Knoblich, M. and Muller, A. and Wolf, J. and Reimer, U. and Leutz, A.
bioRxiv : 238709. 22 December 2017

Deciphering the ubiquitin code.
Dittmar, G. and Selbach, M.
Molecular Cell 65 (5): 779-780. 2 March 2017

omniCLIP: Bayesian identification of protein-RNA interactions from CLIP-Seq data.
Drewe-Boss, P. and Wessels, H.H. and Ohler, U.
bioRxiv : 161877. 11 July 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 5 January 2017

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.
Eichenauer, D.A. and Plütschow, A. and Kreissl, S. and Sökler, M. and Hellmuth, J.C. and Meissner, J. and Mathas, S. and Topp, M.S. and Behringer, K. and Klapper, W. and Kuhnert, G. and Dietlein, M. and Kobe, C. and Fuchs, M. and Diehl, V. and Engert, A. and Borchmann, P.
Lancet Oncology 18 (12): 1680-1687. December 2017

In colon epithelia, Clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement.
Eichner, M. and Augustin, C. and Fromm, A. and Piontek, A. and Walther, W. and Buecker, R. and Fromm, M. and Krause, G. and Schulzke, J.D. and Guenzel, D. and Piontek, J.
Journal of Infectious Diseases 217 (1): 147-157. 27 December 2017

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity.
El-Athman, R. and Genov, N.N. and Mazuch, J. and Zhang, K. and Yu, Y. and Fuhr, L. and Abreu, M. and Li, Y. and Wallach, T. and Kramer, A. and Schmitt, C.A. and Relógio, A.
PLoS Biology 15 (12): e2002940. 7 December 2017

Sugar metabolism of the first thermophilic planctomycete thermogutta terrifontis: comparative genomic and transcriptomic approaches.
Elcheninov, A.G. and Menzel, P. and Gudbergsdottir, S.R. and Slesarev, A.I. and Kadnikov, V.V. and Krogh, A. and Bonch-Osmolovskaya, E.A. and Peng, X. and Kublanov, I.V.
Frontiers in Microbiology 8 : 2140. 2 November 2017

Detecting markers of therapy-induced senescence in cancer cells.
Fan, D.N.Y. and Schmitt, C.A.
Methods in Molecular Biology 1534 : 41-52. 2017

Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, remyelination, tumorigenesis, and hypomyelination.
Fazal, S.V. and Gomez-Sanchez, J.A. and Wagstaff, L.J. and Musner, N. and Otto, G. and Janz, M. and Mirsky, R. and Jessen, K.R.
Journal of Neuroscience 37 (50): 12297-12313. 13 December 2017

Animal models for personalized treatment options.
Fichtner, I. and Klinghammer, K. and Behrens, D. and Flechsig, S. and Rolff, J. and Becker, M. and Wulf-Goldenberg, A. and Stecklum, M. and Rivera, M. and Brzezicha, B. and Jandrig, B. and Hoffmann, J.
International Journal of Clinical Pharmacology and Therapeutics 55 (8): 698-700. August 2017

Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.
Fingleton, B. and Lange, K. and Caldwell, B. and Bankaitis, K.V.
Clinical and Experimental Metastasis 34 (8): 443-447. December 2017

Immunomodulatory molecules in renal cell cancer: CD80 and CD86 are expressed on tumor cells.
Flörcken, A. and Johannsen, M. and Nguyen-Hoai, T. and Gerhardt, A. and Miller, K. and Dörken, B. and Pezzutto, A. and Westermann, J. and Jöhrens, K.
International Journal of Clinical and Experimental Pathology 10 (2): 1443-1454. 15 February 2017

Pan-cancer study of heterogeneous RNA aberrations.
Fonseca, N.A. and Kahles, A. and Lehmann, K.V. and Calabrese, C. and Chateigner, A. and Davidson, N.R. and Demircioglu, D. and He, Y. and Lamaze, F.C. and Li, S. and Liu, D. and Liu, F. and Perry, M.D. and Su, H. and Xiang, L. and Zhang, J. and Amin, S.B. and Bailey, P. and Craft, B. and Frenkel-Morgenstern, M. and Goldman, M. and Greger, L. and Hoadley, K.A. and Hou, Y. and Khurana, E. and Korbel, J.O. and Li, C. and Li, X. and Li, X. and Liu, X. and Lu, Y. and Marin, M.G. and Meyerson, M. and Nandi, T. and Nielsen, M.M. and Ojesina, A.I. and Ouellette, B.F.F. and Pan-Hammarstroem, Q. and Pedamallu, C.S. and Pedersen, J.S. and Shiraishi, Y. and Siebert, R. and Soulette, C.M. and Stark, S.G. and Tan, P. and Teh, B.T. and Valencia, A. and Wang, J. and Xing, R. and Xiong, H. and Yakneen, S. and Ye, C. and Yung, C. and Zhang, F. and Zhang, X. and Zheng, L. and Zhu, J. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Goeke, J. and Schwarz, R.F. and Stegle, O. and Wu, K. and Yang, H. and Zhang, Z. and Brazma, A. and Raetsch, G. and Brooks, A.N.
bioRxiv : 183889. 3 September 2017

Cryo-EM studies of Drp1 reveal cardiolipin interactions that activate the helical oligomer.
Francy, C.A. and Clinton, R.W. and Froehlich, C. and Murphy, C. and Mears, J.A.
Scientific Reports 7 (1): 10744. 6 September 2017

Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma.
Gillissen, B. and Richter, A. and Richter, A. and Preissner, R. and Schulze-Osthoff, K. and Essmann, F. and Daniel, P.T.
Journal of Biological Chemistry 292 (16): 6478-6492. 21 April 2017

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use.
Gleicher, N. and Metzger, J. and Croft, G. and Kushnir, V.A. and Albertini, D.F. and Barad, D.H.
Reproductive Biology and Endocrinology 15 (1): 33. 27 April 2017

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
Gottlieb, A. and Althoff, K. and Grunewald, L. and Thor, T. and Odersky, A. and Schulte, M. and Deubzer, H.E. and Heukamp, L. and Eggert, A. and Schramm, A. and Schulte, J.H. and Künkele, A.
Oncotarget 8 (17): 27882-27891. 25 April 2017

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S. and Zharkov, D.O. and Stahl, J. and Gopanenko, Al.V. and Tupikin, A.E. and Kabilov, M.R. and Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45 (7): 3833-3843. 20 April 2017

Essentials of miRNA-dependent control of mRNA translation and decay, miRNA targeting principles, and methods for target identification.
Grosswendt, S. and Rajewsky, N.
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Technical considerations for the use of CRISPR/Cas9 in hematology research.
Gundry, M.C. and Dever, D.P. and Yudovich, D. and Bauer, D.E. and Haas, S. and Wilkinson, A.C. and Singbrant, S.
Experimental Hematology 54 : 4-11. October 2017

McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
Hafez, D. and Karabacak, A. and Krueger, S. and Hwang, Y.C. and Wang, L.S. and Zinzen, R.P. and Ohler, U.
Genome Biology 18 (1): 199. 26 October 2017

Correcting batch effects in single-cell RNA sequencing data by matching mutual nearest neighbours.
Haghverdi, L. and Lun, A.T.L. and Morgan, M.D. and Marioni, J.C.
bioRxiv : 165118. 18 July 2017

Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes.
Hartung, N. and Benary, U. and Wolf, J. and Kofahl, B.
BMC Systems Biology 11 (1): 98. 13 October 2017

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
Hehlmann, R. and Lauseker, M. and Saußele, S. and Pfirrmann, M. and Krause, S. and Kolb, H.J. and Neubauer, A. and Hossfeld, D.K. and Nerl, C. and Gratwohl, A. and Baerlocher, G.M. and Heim, D. and Brümmendorf, T.H. and Fabarius, A. and Haferlach, C. and Schlegelberger, B. and Müller, M.C. and Jeromin, S. and Proetel, U. and Kohlbrenner, K. and Voskanyan, A. and Rinaldetti, S. and Seifarth, W. and Spieß, B. and Balleisen, L. and Goebeler, M.C. and Hänel, M. and Ho, A. and Dengler, J. and Falge, C. and Kanz, L. and Kremers, S. and Burchert, A. and Kneba, M. and Stegelmann, F. and Köhne, C.A. and Lindemann, H.W. and Waller, C.F. and Pfreundschuh, M. and Spiekermann, K. and Berdel, W.E. and Müller, L. and Edinger, M. and Mayer, J. and Beelen, D.W. and Bentz, M. and Link, H. and Hertenstein, B. and Fuchs, R. and Wernli, M. and Schlegel, F. and Schlag, R. and de Wit, M. and Trümper, L. and Hebart, H. and Hahn, M. and Thomalla, J. and Scheid, C. and Schafhausen, P. and Verbeek, W. and Eckart, M.J. and Gassmann, W. and Pezzutto, A. and Schenk, M. and Brossart, P. and Geer, T. and Bildat, S. and Schäfer, E. and Hochhaus, A. and Hasford, J.
Leukemia 31 (11): 2398-2406. November 2017

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S. and Witte, N. and Weber, P. and Goehring, I. and Tolkachov, A. and von Loeffelholz, C. and Döcke, S. and Bauer, M. and Stockmann, M. and Pfeiffer, A.F.H. and Birkenfeld, A.L. and Pietzke, M. and Kempa, S. and Muenzner, M. and Schupp, M.
Nature Communications 8 (1): 384. 30 August 2017

ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
Heller, D. and Krestel, R. and Ohler, U. and Vingron, M. and Marsico, A.
Nucleic Acids Research 45 (19): 11004-11018. 2 November 2017

Predictive significance of the European LeukemiaNet classification of genetic aberrations in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation.
Hemmati, P.G. and Vuong, L.G. and Terwey, T.H. and Jehn, C.F. and Le Coutre, P. and Penack, O. and Na, I.K. and Dörken, B. and Arnold, R.
European Journal of Haematology 98 (2): 160-168. February 2017

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.
Hendriks, H.R. and Govaerts, A.S. and Fichtner, I. and Burtles, S. and Westwell, A.D. and Peters, G.J.
British Journal of Cancer 117 (2): 195-202. 11 July 2017

PGBD5 promotes site-specific oncogenic mutations in human tumors.
Henssen, A.G. and Koche, R. and Zhuang, J. and Jiang, E. and Reed, C. and Eisenberg, A. and Still, E. and MacArthur, I.C. and Rodríguez-Fos, E. and Gonzalez, S. and Puiggròs, M. and Blackford, A.N. and Mason, C.E. and de Stanchina, E. and Gönen, M. and Emde, A.K. and Shah, M. and Arora, K. and Reeves, C. and Socci, N.D. and Perlman, E. and Antonescu, C.R. and Roberts, C.W.M. and Steen, H. and Mullen, E. and Jackson, S.P. and Torrents, D. and Weng, Z. and Armstrong, S.A. and Kentsis, A.
Nature Genetics 49 (7): 1005-1014. July 2017

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors.
Henssen, A.G. and Koche, R. and Zhuang, J. and Jiang, E. and Reed, C. and Eisenberg, A. and Still, E. and MacArthur, I.C. and Rodríguez-Fos, E. and Gonzalez, S. and Puiggròs, M. and Blackford, A.N. and Mason, C.E. and de Stanchina, E. and Gönen, M. and Emde, An.K. and Shah, M. and Arora, K. and Reeves, C. and Socci, N.D. and Perlman, E. and Antonescu, C.R. and Roberts, C.W.M. and Steen, H. and Mullen, E. and Jackson, S.P. and Torrents, D. and Weng, Z. and Armstrong, S.A. and Kentsis, A.
bioRxiv : 111138. 23 February 2017

Targeting tachykinin receptors in neuroblastoma.
Henssen, A.G. and Odersky, A. and Szymansky, A. and Seiler, M. and Althoff, K. and Beckers, A. and Speleman, F. and Schäfers, S. and De Preter, K. and Astrahanseff, K. and Struck, J. and Schramm, A. and Eggert, A. and Bergmann, A. and Schulte, J.H.
Oncotarget 8 (1): 430-443. 3 January 2017

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. and Reed, C. and Jiang, E. and Garcia, H.D. and von Stebut, J. and MacArthur, I.C. and Hundsdoerfer, P. and Kim, J.H. and de Stanchina, E. and Kuwahara, Y. and Hosoi, H. and Ganem, N.J. and Dela Cruz, F. and Kung, A.L. and Schulte, J.H. and Petrini, J.H. and Kentsis, A.
Science Translational Medicine 9 (414): eaam9078. 1 November 2017

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. and Reed, Casie and Jiang, Eileen and Garcia, H.D. and von Stebut, J. and MacArthur, I.C. and Hundsdoerfer, P. and Kim, J.H. and de Stanchina, E. and Kuwahara, Y. and Hosoi, H. and Ganem, N. and Cruz, F.D. and Kung, A.L. and Schulte, J.H. and Petrini, J.H. and Kentsis, A.
bioRxiv : 181040. 25 August 2017

CTLA4 promotes Tyk2-STAT3 dependent B-cell oncogenecity.
Herrmann, A. and Lahtz, C. and Nagao, T. and Song, J.Y. and Chan, W.C. and Lee, H. and Yue, C. and Look, T. and Muelfarth, R. and Li, W. and Jenkins, K. and Williams, J. and Budde, L.E. and Forman, S.J. and Kwak, L.W. and Blankenstein, T. and Yu, H.
Cancer Research 77 (18): 5118-5128. 15 September 2017

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M. and Zerbes, R.M. and Rampelt, H. and Kunz, S. and Xavier, A.H. and Purfürst, B. and Lilie, H. and Pfanner, N. and van der Laan, M. and Daumke, O.
Nature Communications 8 : 15258. 31 May 2017

Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo.
Hirche, C. and Frenz, T. and Haas, S.F. and Döring, M. and Borst, K. and Tegtmeyer, P.K. and Brizic, I. and Jordan, S. and Keyser, K. and Chhatbar, C. and Pronk, E. and Lin, S. and Messerle, M. and Jonjic, S. and Falk, C.S. and Trumpp, A. and Essers, M.A.G. and Kalinke, U.
Cell Reports 19 (11): 2345-2356. 13 June 2017

Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E.
Cancer Discovery 7 (1): 14-16. January 2017

Determinants of transcription initiation directionality in metazoans.
Ibrahim, M.M. and Karabacak, A. and Glahs, A. and Kolundzic, E. and Hirsekorn, A. and Carda, A. and Tursun, B. and Zinzen, R.P. and Lacadie, S.A. and Ohler, U.
bioRxiv : 224642. 24 November 2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F. and Maurizio, J. and Vargas Aguilar, S. and Busch, C.J. and Favret, J. and Kowenz-Leutz, E. and Cathou, W. and Gentek, R. and Perrin, P. and Leutz, A. and Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

Compound annotation in liquid chromatography/high-resolution mass spectrometry based metabolomics: robust adduct ion determination as a prerequisite to structure prediction in electrospray ionization mass spectra.
Jaeger, C. and Méret, M. and Schmitt, C.A. and Lisec, J.
Rapid Communications in Mass Spectrometry 31 (15): 1261-1266. 15 August 2017

Tracking the evolution of non-small-cell lung cancer.
Jamal-Hanjani, M. and Wilson, G.A. and McGranahan, N. and Birkbak, N.J. and Watkins, T.B.K. and Veeriah, S. and Shafi, S. and Johnson, D.H. and Mitter, R. and Rosenthal, R. and Salm, M. and Horswell, S. and Escudero, M. and Matthews, N. and Rowan, A. and Chambers, T. and Moore, D.A. and Turajlic, S. and Xu, H. and Lee, S.-M. and Forster, M.D. and Ahmad, T. and Hiley, C.T. and Abbosh, C. and Falzon, M. and Borg, E. and Marafioti, T. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P.A. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Dentro, S. and Taniere, P. and O'Sullivan, B. and Lowe, H.L. and Hartley, J.A. and Iles, N. and Bell, H. and Ngai, Y. and Shaw, J.A. and Herrero, J. and Szallasi, Z. and Schwarz, R.F. and Stewart, A. and Quezada, S.A. and Le Quesne, J. and Van Loo, P. and Dive, C. and Hackshaw, A. and Swanton, C.
New England Journal of Medicine 376 (22): 2109-2121. 1 June 2017

Tricellulin is a target of the ubiquitin ligase Itch.
Jennek, S. and Mittag, S. and Reiche, J. and Westphal, J.K. and Seelk, S. and Dörfel, M.J. and Pfirrmann, T. and Friedrich, K. and Schütz, A. and Heinemann, U. and Huber, O.
Annals of the New York Academy of Sciences 1397 (1): 157-168. June 2017

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.
Jerke, U. and Marino, S.F. and Daumke, O. and Kettritz, R.
Scientific Reports 7 : 43328. 27 February 2017

TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression.
Jiang, C. and Zhu, Y. and Zhou, Z. and Gumin, J. and Bengtsson, L. and Wu, W. and Songyang, Z. and Lang, F.F. and Lin, X.
Oncogene 36 (20): 2813-2823. 18 May 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Juneja, M. and Kobelt, D. and Walther, W. and Voss, C. and Smith, J. and Specker, E. and Neuenschwander, M. and Gohlke, B.O. and Dahlmann, M. and Radetzki, S. and Preissner, R. and von Kries, J.P. and Schlag, P.M. and Stein, U.
PLoS Biology 15 (6): e2000784. 1 June 2017

Massively parallel clonal analysis using CRISPR/Cas9 induced genetic scars.
Junker, J.P. and Spanjaard, B. and Peterson-Maduro, J. and Alemany, A. and Hu, B. and Florescu, M. and van Oudenaarden, A.
bioRxiv : 056499. 4 January 2017

Development of mouse model systems of germinal center lymphomas.
Kabrani, E. and Sander, S.
Methods in Molecular Biology 1623 : 233-242. 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

mRNA interactome capture in mammalian cells.
Kastelic, N. and Landthaler, M.
Methods 126 : 38-43. 15 August 2017

Choosing wisely - Preclinical test models in the era of precision medicine.
Klinghammer, K. and Walther, W. and Hoffmann, J.
Cancer Treatment Reviews 55 : 36-45. April 2017

FACT sets a barrier for cell fate reprogramming in C. elegans and human.
Kolundzic, E. and Ofenbauer, A. and Uyar, B. and Sommermeier, A. and Seelk, S. and He, M. and Baytek, G. and Akalin, A. and Diecke, S. and Lacadie, S.A. and Tursun, B.
bioRxiv : 185116. 6 September 2017

T cell receptors for clinical therapy: in vitro assessment of toxicity risk.
Kunert, A. and Obenaus, M. and Lamers, C.H.J. and Blankenstein, T. and Debets, R.
Clinical Cancer Research 23 (20): 6012-6020. 15 October 2017

Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.
Lacraz, G.P.A. and Junker, J.P. and Gladka, M.M. and Molenaar, B. and Scholman, K.T. and Vigil-Garcia, M. and Versteeg, D. and de Ruiter, H. and Vermunt, M.W. and Creyghton, M.P. and Huibers, M.M.H. and de Jonge, N. and van Oudenaarden, A. and van Rooij, E.
Circulation 136 (15): 1396-1409. 10 October 2017

Master and commander? FoxO's role in muscle atrophy.
Langer, H.T.
Journal of Physiology 595 (14): 4593-4594. 15 July 2017

Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.
Lin, L. and Petersen, T.S. and Jensen, K.T. and Bolund, L. and Kühn, R. and Luo, Y.
Journal of Biotechnology 247 : 42-49. 10 April 2017

Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.
Lodrini, M. and Sprüssel, A. and Astrahantseff, K. and Tiburtius, D. and Konschak, R. and Lode, H.N. and Fischer, M. and Keilholz, U. and Eggert, A. and Deubzer, H.E.
Oncotarget 8 (49): 85234-85251. 17 October 2017

Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy.
Lorenz, F.K.M. and Ellinger, C. and Kieback, E. and Wilde, S. and Lietz, M. and Schendel, D.J. and Uckert, W.
Human Gene Therapy 28 (12): 1158-1168. 1 December 2017

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
Lutter, D. and Ullrich, F. and Lueck, J.C. and Kempa, S. and Jentsch, T.J.
Journal of Cell Science 130 (6): 1122-1133. 15 March 2017

Transcriptome-wide identification of RNA-binding protein binding sites using photoactivatable-ribonucleoside-enhanced crosslinking immunoprecipitation (PAR-CLIP).
Maatz, H. and Kolinski, M. and Hubner, N. and Landthaler, M.
Current Protocols in Molecular Biology 118 : 27.6.1-27.6.19. 3 April 2017

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M. and Kirchner, M. and Aharoni, R. and Ciolli Mattioli, C. and van den Bruck, D. and Gutkovitch, N. and Modepalli, V. and Selbach, M. and Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45 (2): 938-950. 25 January 2017

Structural insights into the activation mechanism of dynamin-like EHD ATPases.
Melo, A.A. and Hegde, B.G. and Shah, C. and Larsson, E. and Isas, J.M. and Kunz, S. and Lundmark, R. and Langen, R. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 114 (22): 5629-5634. 30 May 2017

Degrons in cancer.
Meszaros, B. and Kumar, M. and Gibson, T.J. and Uyar, B. and Dosztanyi, Z.
Science Signaling 10 (470): eaak9982. 14 March 2017

In silico methods for co-transcriptional RNA secondary structure prediction and for investigating alternative RNA structure expression.
Meyer, I.M.
Methods 120 : 3-16. 1 May 2017

Mutations in disordered regions cause disease by creating endocytosis motifs.
Meyer, K. and Uyar, B. and Kirchner, M. and Cheng, J. and Akalin, A. and Selbach, M.
bioRxiv : 141622. 24 May 2017

Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor.
Mildner, A.
Neural Regeneration Research 12 (4): 570-571. April 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. and Schönheit, J. and Giladi, A. and David, E. and Lara-Astiaso, D. and Lorenzo-Vivas, E. and Paul, F. and Chappell-Maor, L. and Priller, J. and Leutz, A. and Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M. and Imami, K. and Mukherjee, N. and De Bortoli, F. and Zinnall, U. and Hazapis, O. and Trahan, C. and Oeffinger, M. and Heyd, F. and Ohler, U. and Selbach, M. and Landthaler, M.
Genome Research 27 (8): 1344-1359. August 2017

Tumor-infiltrating merkel cell polyomavirus-specific T cells are diverse and associated with improved patient survival.
Miller, N.J. and Church, C.D. and Dong, L. and Crispin, D. and Fitzgibbon, M.P. and Lachance, K. and Jing, L. and Shinohara, M. and Gavvovidis, I. and Willimsky, G. and McIntosh, M. and Blankenstein, T. and Koelle, D.M. and Nghiem, P.
Cancer Immunology Research 5 (2): 137-147. February 2017

Casein kinase 1-epsilonor1-delta required for Wnt-mediated intestinal stem cell maintenance.
Morgenstern, Y. and Das Adhikari, U. and Ayyash, M. and Elyada, E. and Tóth, B. and Moor, A. and Itzkovitz, S. and Ben-Neriah, Y.
EMBO Journal 36 (20): 3046-3061. 16 October 2017

Developmental origin and maintenance of distinct testicular macrophage populations.
Mossadegh-Keller, N. and Gentek, R. and Gimenez, G. and Bigot, S. and Mailfert, S. and Sieweke, M.H.
Journal of Experimental Medicine 214 (10): 2829-2841. 2 October 2017

MACC1, a novel player in solid cancer carcinogenesis.
Mudduluru, G. and Ilm, K. and Dahlmann, M. and Stein, U.
In: Mechanisms of Molecular Carcinogenesis - Volume 1. Springer, Cham, 11-38. ISBN 978-3-319-53657-6 2017

Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression.
Mudduluru, G. and Ilm, K. and Fuchs, S. and Stein, U.
Oncotarget 8 (13): 21081-21094. 28 March 2017

Integrative classification of human coding and noncoding genes through RNA metabolism profiles.
Mukherjee, N. and Calviello, L. and Hirsekorn, A. and de Pretis, S. and Pelizzola, M. and Ohler, U.
Nature Structural & Molecular Biology 24 (1): 86-96. January 2017

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
Mönke, G. and Cristiano, E. and Finzel, A. and Friedrich, D. and Herzel, H. and Falcke, M. and Loewer, A.
Scientific Reports 7 : 46571. 18 April 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F. and Rapp, A. and Yu, W. and Maiser, A. and Harz, H. and Scholl, A. and Grulich, S. and Anton, T. and Hoerl, D. and Chen, W. and Durante, M. and Taucher-Scholz, G. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

Underlying mechanisms for distant metastasis - molecular biology.
Pachmayr, E. and Treese, C. and Stein, U.
Visceral Medicine 33 (1): 11-20. February 2017

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J. and Menzel, L. and Niesler, N. and Kobelt, D. and Aumann, J. and Rivera, M. and Walther, W.
BMC Cancer 17 (1): 129. 13 February 2017

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Pajtler, K.W. and Sadowski, N. and Ackermann, S. and Althoff, K. and Schönbeck, K. and Batzke, K. and Schäfers, S. and Odersky, A. and Heukamp, L. and Astrahantseff, K. and Künkele, A. and Deubzer, H.E. and Schramm, A. and Sprüssel, A. and Thor, T. and Lindner, S. and Eggert, A. and Fischer, M. and Schulte, J.H.
Oncotarget 8 (4): 6730-6741. 24 January 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Quantitative GTPase affinity purification identifies Rho family protein interaction partners.
Paul, F. and Zauber, H. and von Berg, L. and Rocks, O. and Daumke, O. and Selbach, M.
Molecular & Cellular Proteomics 16 (1): 73-85. 1 January 2017

Pontine tegmental cap dysplasia in an extremely preterm infant and review of the literature.
Picker-Minh, S. and Hartenstein, S. and Proquitte, H. and Froehler, S. and Raile, V. and Kraemer, N. and Apeshiotis, S. and Leipoldt, M. and Kalache, K.D. and Morris-Rosendahl, D. and Boltshauser, E. and Chen, W. and Kaindl, A.M.
Journal of Child Neurology 32 (3): 334-340. March 2017

JACUSA: site-specific identification of RNA editing events from replicate sequencing data.
Piechotta, M. and Wyler, E. and Ohler, U. and Landthaler, M. and Dieterich, C.
BMC Bioinformatics 18 (1): 7. 3 January 2017

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K. and Tan, J. and Piccoli, L. and Foglierini, M. and Barbieri, S. and Chen, Y. and Silacci-Fregni, C. and Wolf, T. and Jarrossay, D. and Anderle, M. and Abdi, A. and Ndungu, F.M. and Doumbo, O.K. and Traore, B. and Tran, T.M. and Jongo, S. and Zenklusen, I. and Crompton, P.D. and Daubenberger, C. and Bull, P.C. and Sallusto, F. and Lanzavecchia, A.
Nature 548 (7669): 597-601. 31 August 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Evolutionary plasticity in the innate immune function of Akirin.
Polanowska, J. and Chen, J.X. and Soule, J. and Omi, S. and Belougne, J. and Taffoni, C. and Pujol, N. and Selbach, M. and Zugasti, O. and Ewbank, J.J.
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Dense and accurate whole-chromosome haplotyping of individual genomes.
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Different inhibitory potencies of oseltamivir carboxylate, zanamivir, and several tannins on bacterial and viral neuraminidases as assessed in a cell-free fluorescence-based enzyme inhibition assay.
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MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers.
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MAD2L2 promotes open chromatin in embryonic stem cells and derepresses the Dppa3 locus.
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George Klein: 1925-2016.
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National Academy of Sciences. 28 March 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
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Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
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Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies.
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The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance.
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Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy.
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
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RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
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Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors.
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The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
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In vitro and in vivo investigations into the carbene gold chloride and thioglucoside anticancer drug candidates NHC-AuCl and NHC-AuSR.
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Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models.
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EBI2 is highly expressed in multiple sclerosis lesions and promotes early CNS migration of encephalitogenic CD4 T cells.
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Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.
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EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.
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Approaches and techniques to characterize cancer metabolism in vitro and in vivo.
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RNA localization is a key determinant of neurite-enriched proteome.
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Picky: a simple method designer for targeted proteomics.
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DNA base flipping analytical pipeline.
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RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints.
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Trained macrophages support hygiene hypothesis.
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Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations.
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Metabolism in cancer.
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KCNE2 and gastric cancer: bench to bedside.
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The metabolic background is a global player in Saccharomyces gene expression epistasis.
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destiny: diffusion maps for large-scale single-cell data in R.
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Bioinformatics 32 (8): 1241-1243. 15 April 2016

Membrane fission by dynamin: what we know and what we need to know.
Antonny, B. and Burd, C. and De Camilli, P. and Chen, E. and Daumke, O. and Faelber, K. and Ford, M. and Frolov, V.A. and Frost, A. and Hinshaw, J.E. and Kirchhausen, T. and Kozlov, M.M. and Lenz, M. and Low, H.H. and McMahon, H. and Merrifield, C. and Pollard, T.D. and Robinson, P.J. and Roux, A. and Schmid, S.
EMBO Journal 35 (21): 2270-2284. 2 November 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.
Ashktorab, H. and Hermann, P. and Nouraie, M. and Shokrani, B. and Lee, E. and Haidary, T. and Brim, H. and Stein, U.
Journal of Translational Medicine 14 (1): 215. 20 July 2016

Dynamics of the ligand binding domain layer during AMPA receptor activation.
Baranovic, J. and Chebli, M. and Salazar, H. and Carbone, A.L. and Faelber, K. and Lau, A.Y. and Daumke, O. and Plested, A.J.R.
Biophysical Journal 110 (4): 896-911. 23 February 2016

OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation.
Barrera, M. and Koob, S. and Dikov, D. and Vogel, F. and Reichert, A.S.
FEBS Letters 590 (19): 3309-3322. October 2016

Feedback, mass conservation and reaction kinetics impact the robustness of cellular oscillations.
Baum, K. and Politi, A.Z. and Kofahl, B. and Steuer, R. and Wolf, J.
PLoS Computational Biology 12 (12): e1005298. 27 December 2016

Poly(ADP-ribosyl)ation of Methyl CpG binding domain protein 2 regulates chromatin structure.
Becker, A. and Zhang, P. and Allmann, L. and Meilinger, D. and Bertulat, B. and Eck, D. and Hofstaetter, M. and Bartolomei, G. and Hottiger, M.O. and Schreiber, V. and Leonhardt, H. and Cardoso, M.C.
Journal of Biological Chemistry 291 (10): 4873-4881. 4 March 2016

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Becker, M.S. and Müller, P.M. and Bajorat, J. and Schroeder, A. and Giaisi, M. and Amin, E. and Ahmadian, M.R. and Rocks, O. and Köhler, R. and Krammer, P.H. and Li-Weber, M.
Oncotarget 7 (32): 51908-51921. 9 August 2016

A c-Myc/miR17-92/Pten axis controls PI3K-mediated positive and negative selection in B cell development and reconstitutes CD19 deficiency.
Benhamou, D. and Labi, V. and Novak, R. and Dai, I. and Shafir-Alon, S. and Weiss, A. and Gaujoux, R. and Arnold, R. and Shen-Orr, S.S. and Rajewsky, K. and Melamed, D.
Cell Reports 16 (2): 419-431. 12 July 2016

Isolation of eosinophils from the lamina propria of the murine small intestine.
Berek, C. and Beller, A. and Chu, V.T.
Methods in Molecular Biology 1422 : 213-221. 2016

Multiple myeloma cells modify VEGF/IL-6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR-223.
Berenstein, R. and Nogai, A. and Waechter, M. and Blau, O. and Kuehnel, A. and Schmidt-Hieber, M. and Kunitz, A. and Pezzutto, A. and Dörken, B. and Blau, I.W.
Molecular Carcinogenesis 55 (12): 1927-1939. December 2016

Domain-swapped T cell receptors improve the safety of TCR gene therapy.
Bethune, M.T. and Gee, M.H. and Bunse, M. and Lee, M.S. and Gschweng, E.H. and Pagadala, M.S. and Zhou, J. and Cheng, D. and Heath, J.R. and Kohn, D.B. and Kuhns, M.S. and Uckert, W. and Baltimore, D.
eLife 5 : e19095. 8 November 2016

Orchestrating Wnt signalling for metabolic liver zonation.
Birchmeier, W.
Nature Cell Biology 18 (5): 463-465. May 2016

Receptor combinations hone T-cell therapy.
Blankenstein, T.
Nature Biotechnology 34 (4): 389-391. 7 April 2016

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.
Braten, O. and Livneh, I. and Ziv, T. and Admon, A. and Kehat, I. and Caspi, L.H. and Gonen, H. and Bercovich, B. and Godzik, A. and Jahandideh, S. and Jaroszewski, L. and Sommer, T. and Kwon, Y.T. and Guharoy, M. and Tompa, P. and Ciechanover, A.
Proceedings of the National Academy of Sciences of the United States of America 113 (32): E4639-E4647. 9 August 2016

Modeling cardiovascular diseases with patient-specific human pluripotent stem cell-derived cardiomyocytes.
Burridge, P.W. and Diecke, S. and Matsa, E. and Sharma, A. and Wu, H. and Wu, J.C.
Methods in Molecular Biology 1353 : 119-130. 2016

Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L. and Mukherjee, N. and Wyler, E. and Zauber, H. and Hirsekorn, A. and Selbach, M. and Landthaler, M. and Obermayer, B. and Ohler, U.
Nature Methods 13 (2): 165-170. February 2016

On fine stochastic simulations of liposome-encapsulated PUREsystem(TM).
Calviello, L. and Lazzerini-Ospri, L. and Marangoni, R.
In: 10th Italian Workshop on Artificial Life and Evolutionary Computation, WIVACE 2015, 22-25 Sept 2015, Bari, Italy. 2016

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Casado-Medrano, V. and Barrio-Real, L. and García-Rostán, G. and Baumann, M. and Rocks, O. and Caloca, M.J.
Oncotarget 7 (19): 28301-28319. 10 May 2016

Eyes on translation.
Chekulaeva, M. and Landthaler, M.
Molecular Cell 63 (6): 918-925. 15 September 2016

miR-23~27~24 clusters control effector T cell differentiation and function.
Cho, S. and Wu, C.J. and Yasuda, T. and Cruz, L.O. and Khan, A.A. and Lin, L.L. and Nguyen, D.T. and Miller, M. and Lee, H.M. and Kuo, M.L. and Broide, D.H. and Rajewsky, K. and Rudensky, A.Y. and Lu, L.F.
Journal of Experimental Medicine 213 (2): 235-249. 8 February 2016

T cell PTLD successfully treated with single-agent brentuximab vedotin first-line therapy.
Choi, M. and Fink, S. and Prasad, V. and Anagnostopoulos, I. and Reinke, P. and Schmitt, C.A.
Transplantation 100 (3): e8-e10. March 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T. and Graf, R. and Wirtz, T. and Weber, T. and Favret, J. and Li, X. and Petsch, K. and Tran, N.T. and Sieweke, M.H. and Berek, C. and Kühn, R. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519. 1 November 2016

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.
Chu, V.T. and Weber, T. and Graf, R. and Sommermann, T. and Petsch, K. and Sack, U. and Volchkov, P. and Rajewsky, K. and Kühn, R.
BMC Biotechnology 16 (1): 4. 16 January 2016

miRNAs are essential for the regulation of the PI3K/AKT/FOXO pathway and receptor editing during B cell maturation.
Coffre, M. and Benhamou, D. and Riess, D. and Blumenberg, L. and Snetkova, V. and Hines, M.J. and Chakraborty, T. and Bajwa, S. and Jensen, K. and Chong, M.M.W. and Getu, L. and Silverman, G.J. and Blelloch, R. and Littman, D.R. and Calado, D. and Melamed, D. and Skok, J.A. and Rajewsky, K. and Koralov, S.B.
Cell Reports 17 (9): 2271-2285. 22 November 2016

Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Mueller, R. and Heinemann, U. and Kaupp, M. and Wahl, M. and Risse, T.
Journal of the American Chemical Society 138 (39): 12868-12875. 5 October 2016

S100A4 in cancer metastasis: Wnt signaling-driven interventions for metastasis restriction.
Dahlmann, M. and Kobelt, D. and Walther, W. and Mudduluru, G. and Stein, U.
Cancers 8 (6): 59. 20 June 2016

Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamily.
Daumke, O. and Praefcke, G.J.
Biopolymers 105 (8): 580-593. August 2016

Protein-mediated membrane remodeling.
Daumke, O. and Unger, V.M.
Journal of Structural Biology 196 (1): 1-2. October 2016

Self-organization of human embryonic stem cells on micropatterns.
Deglincerti, A. and Etoc, F. and Guerra, M.C. and Martyn, I. and Metzger, J. and Ruzo, A. and Simunovic, M. and Yoney, A. and Brivanlou, A.H. and Siggia, E. and Warmflash, A.
Nature Protocols 11 (11): 2223-2232. November 2016

Random focusing of tsunami waves.
Degueldre, H. and Metzger, J.J. and Geisel, T. and Fleischmann, R.
Nature Physics 12 (3): 259-262. March 2016

Interleukin-7 modulates anti-tumor CD8+ T cell responses via its action on host cells.
Deiser, K. and Stoycheva, D. and Bank, U. and Blankenstein, T. and Schüler, T.
PLoS ONE 11 (7): e0159690. 22 July 2016

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A. and Schröter, M.F. and Perets, E. and Skroblin, P. and Moutty, M.C. and Deàk, V.A. and Birchmeier, W. and Klussmann, E.
Journal of Biological Chemistry 291 (37): 19618-19630. 9 September 2016

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Derudder, E. and Herzog, S. and Labi, V. and Yasuda, T. and Köchert, K. and Janz, M. and Villunger, A. and Schmidt-Supprian, M. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5065-5070. 3 May 2016

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells.
Drachsler, M. and Kleber, S. and Mateos, A. and Volk, K. and Mohr, N. and Chen, S. and Cirovic, B. and Tuettenberg, J. and Gieffers, C. and Sykora, J. and Wirtz, C.R. and Mueller, W. and Synowitz, M. and Martin-Villalba, A.
Cell Death & Disease 7 : e2209. 28 April 2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P. and Nordström, K. and Gasparoni, G. and Salhab, A. and Kressler, C. and de Almeida, M. and Bassler, K. and Ulas, T. and Schmidt, F. and Xiong, J. and Glažar, P. and Klironomos, F. and Sinha, A. and Kinkley, S. and Yang, X. and Arrigoni, L. and Amirabad, A.. and Ardakani, F.B. and Feuerbach, L. and Gorka, O. and Ebert, P. and Müller, F. and Li, N. and Frischbutter, S. and Schlickeiser, S. and Cendon, C. and Fröhler, S. and Felder, B. and Gasparoni, N. and Imbusch, C.D. and Hutter, B. and Zipprich, G. and Tauchmann, Y. and Reinke, S. and Wassilew, G. and Hoffmann, U. and Richter, A.S. and Sieverling, L. and Chang, H.D. and Syrbe, U. and Kalus, U. and Eils, J. and Brors, B. and Manke, T. and Ruland, J. and Lengauer, T. and Rajewsky, N. and Chen, W. and Dong, J. and Sawitzki, B. and Chung, H.R. and Rosenstiel, P. and Schulz, M.H. and Schultze, J.L. and Radbruch, A. and Walter, J. and Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma.
Däbritz, J.H.M. and Yu, Y. and Milanovic, M. and Schönlein, M. and Rosenfeldt, M.T. and Dörr, J.R. and Kaufmann, A.M. and Dörken, B. and Schmitt, C.A.
Molecular Cancer Therapeutics 15 (5): 1074-1081. May 2016

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Ebstein, F. and Textoris-Taube, K. and Keller, C. and Golnik, R. and Vigneron, N. and Van den Eynde, B.J. and Schuler-Thurner, B. and Schadendorf, D. and Lorenz, F.K.M. and Uckert, W. and Urban, S. and Lehmann, A. and Albrecht-Koepke, N. and Janek, K. and Henklein, P. and Niewienda, A. and Kloetzel, P.M. and Mishto, M.
Scientific Reports 6 : 24032. 6 April 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak and augments drug response.
Einsele-Scholz, S. and Malmsheimer, S. and Bertram, K. and Stehle, D. and Johaenning, J. and Manz, M. and Daniel, P.T. and Gillissen, B.F. and Schulze-Osthoff, K. and Essmann, F.
Journal of Cell Science 129 (11): 2213-2223. 1 June 2016

The European Hematology Association Roadmap for European Hematology Research: a consensus document.
Engert, A. and Balduini, C. and Brand, A. and Coiffier, B. and Cordonnier, C. and Doehner, H. and Duyvene' de Wit, T. and Eichinger, S. and Fibbe, W. and Green, T. and de Haas, F. and Iolascon, A. and Jaffredo, T. and Rodeghiero, F. and Salles, G. and Schuringa, J.J.
Haematologica 101 (2): 115-208. February 2016

A balance between secreted inhibitors and edge sensing controls gastruloid self-organization.
Etoc, F. and Metzger, J. and Ruzo, A. and Kirst, C. and Yoney, A. and Ozair, M.Z. and Brivanlou, A.H. and Siggia, E.D.
Developmental Cell 39 (3): 302-315. 7 November 2016

Non-equilibrium steady states of stochastic processes with intermittent resetting.
Eule, S. and Metzger, J.J.
New Journal of Physics 18 (3): 033006. March 2016

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.
Fabian, J. and Opitz, D. and Althoff, K. and Lodrini, M. and Hero, B. and Volland, R. and Beckers, A. and de Preter, K. and Decock, A. and Patil, N. and Abba, M. and Kopp-Schneider, A. and Astrahantseff, K. and Wünschel, J. and Pfeil, S. and Ercu, M. and Künkele, A. and Hu, J. and Thole, T. and Schweizer, L. and Mechtersheimer, G. and Carter, D. and Cheung, B.B. and Popanda, O. and von Deimling, A. and Koster, J. and Versteeg, R. and Schwab, M. and Marshall, G.M. and Speleman, F. and Erb, U. and Zoeller, M. and Allgayer, H. and Simon, T. and Fischer, M. and Kulozik, A.E. and Eggert, A. and Witt, O. and Schulte, J.H. and Deubzer, H.E.
Oncotarget 7 (41): 66344-66359. 11 October 2016

A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis.
Fang, L. and Zhu, Q. and Neuenschwander, M. and Specker, E. and Wulf-Goldenberg, A. and Weis, W.I. and von Kries, J.P. and Birchmeier, W.
Cancer Research 76 (4): 891-901. 15 February 2016

Immunological memory: lessons from the past and a look to the future.
Farber, D.L. and Netea, M.G. and Radbruch, A. and Rajewsky, K. and Zinkernagel, R.M.
Nature Reviews Immunology 16 (2): 124-128. February 2016

The translational potential of microRNAs as biofluid markers of urological tumours.
Fendler, A. and Stephan, C. and Yousef, G.M. and Kristiansen, G. and Jung, K.
Nature Reviews Urology 13 (12): 734-752. December 2016

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
Ferone, G. and Song, J.Y. and Sutherland, K.D. and Bhaskaran, R. and Monkhorst, K. and Lambooij, J.P. and Proost, N. and Gargiulo, G. and Berns, A.
Cancer Cell 30 (4): 519-532. 10 October 2016

Radioimmunotherapy in relapsed/refractory mantle cell lymphoma patients: final results of a European MCL network phase II trial.
Ferrero, S. and Pastore, A. and Scholz, C.W. and Forstpointner, R. and Pezzutto, A. and Bergmann, L. and Truemper, L. and Finke, J. and Keller, U. and Ghione, P. and Passera, R. and Hiddemann, W. and Weigert, O. and Unterhalt, M. and Dreyling, M.
Leukemia 30 (4): 984-987. April 2016

DC generation from peripheral blood mononuclear cells in patients with chronic myeloid leukemia: Influence of interferons on DC yield and functional properties.
Floercken, A. and Kopp, J. and Kölsch, U. and Meisel, C. and Dörken, B. and Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 12 (5): 1117-1123. 3 May 2016

Polycomb and lung cancer: when the dosage makes the (kind of) poison.
Gargiulo, G. and Citterio, E. and Serresi, M.
Molecular & Cellular Oncology 3 (3): e1152345. May 2016

Targeted application of human genetic variation can improve red blood cell production from stem cells.
Giani, F.C. and Fiorini, C. and Wakabayashi, A. and Ludwig, L.S. and Salem, R.M. and Jobaliya, C.D. and Regan, S.N. and Ulirsch, J.C. and Liang, G. and Steinberg-Shemer, O. and Guo, M.H. and Esko, T. and Tong, W. and Brugnara, C. and Hirschhorn, J.N. and Weiss, M.J. and Zon, L.I. and Chou, S.T. and French, D.L. and Musunuru, K. and Sankaran, V.G.
Cell Stem Cell 18 (1): 73-78. 7 January 2016

TERT core promotor mutations in early-onset bladder cancer.
Giedl, J. and Rogler, A. and Wild, A. and Riener, M.O. and Filbeck, T. and Burger, M. and Ruemmele, P. and Hurst, C. and Knowles, M. and Hartmann, A. and Zinnall, U. and Stoehr, R.
Journal of Cancer 7 (8): 915-920. 7 May 2016

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. and Ammar, I. and Gupta, S. and Bunse, M. and Miskey, C. and Chen, W. and Uckert, W. and Schulz, T.F. and Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

CancerResource - updated database of cancer-relevant proteins, mutations and interacting drugs.
Gohlke, B.O. and Nickel, J. and Otto, R. and Dunkel, M. and Preissner, R.
Nucleic Acids Research 44 (D1): D932-D937. 4 January 2016

Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Gätjen, M. and Brand, F. and Grau, M. and Gerlach, K. and Kettritz, R. and Westermann, J. and Anagnostopoulos, I. and Lenz, P. and Lenz, G. and Höpken, U.E. and Rehm, A.
Cancer Research 76 (18): 5253-5265. 15 September 2016

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Götz, F. and Roske, Y. and Schulz, M.S. and Autenrieth, K. and Bertinetti, D. and Faelber, K. and Zühlke, K. and Kreuchwig, A. and Kennedy, E. and Krause, G. and Daumke, O. and Herberg, F.W. and Heinemann, U. and Klussmann, E.
Biochemical Journal 473 (13): 1881-1894. 28 June 2016

Diffusion pseudotime robustly reconstructs lineage branching.
Haghverdi, L. and Büttner, M. and Wolf, F. A. and Buettner, F. and Theis, F.J.
bioRxiv : 041384. 2 March 2016

Diffusion pseudotime robustly reconstructs lineage branching.
Haghverdi, L. and Büttner, M. and Wolf, F.A. and Buettner, F. and Theis, F.J.
Nature Methods 13 (10): 845-848. October 2016

Alternative splicing substantially diversifies the transcriptome during early photomorphogenesis and correlates with the energy availability in arabidopsis.
Hartmann, L. and Drewe-Boss, P. and Wiessner, T. and Wagner, G. and Geue, S. and Lee, H.C. and Obermueller, D.M. and Kahles, A. and Behr, J. and Sinz, F.H. and Raetsch, G. and Wachter, A.
Plant Cell 28 (11): 2715-2734. November 2016

ssHMM: Extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
Heller, D. and Krestel, R. and Ohler, U. and Vingron, M. and Marsico, A.
bioRxiv : 076034. 11 October 2016

Targeting MYCN-driven transcription by BET-bromodomain inhibition.
Henssen, A. and Althoff, K. and Odersky, A. and Beckers, A. and Koche, R. and Speleman, F. and Schäfers, S. and Bell, E. and Nortmeyer, M. and Westermann, F. and De Preter, K. and Florin, A. and Heukamp, L. and Spruessel, A. and Astrahanseff, K. and Lindner, S. and Sadowski, N. and Schramm, A. and Astorgues-Xerri, L. and Riveiro, M.E. and Eggert, A. and Cvitkovic, E. and Schulte, J.H.
Clinical Cancer Research 22 (10): 2470-2481. May 2016

Cytoarchitecture and probability maps of the human medial orbitofrontal cortex.
Henssen, A. and Zilles, K. and Palomero-Gallagher, N. and Schleicher, A. and Mohlberg, H. and Gerboga, F. and Eickhoff, S.B. and Bludau, S. and Amunts, K.
Cortex 75 : 87-112. February 2016

Forward genetic screen of human transposase genomic rearrangements.
Henssen, A.G. and Jiang, E. and Zhuang, J. and Pinello, L. and Socci, N.D. and Koche, R. and Gonen, M. and Villasante, C.M. and Armstrong, S.A. and Bauer, D.E. and Weng, Z. and Kentsis, A.
BMC Genomics 17 : 548. 4 August 2016

Forward genetic screen of human transposase genomic rearrangements.
Henssen, A.G. and Jiang, E. and Zhuang, J. and Pinello, L. and Socci, N.D. and Koche, R. and Gonen, M. and Villasante, C.M. and Armstrong, S.A. and Bauer, D.E. and Weng, Z. and Kentsis, A.
bioRxiv : 061770. 1 July 2016

DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L. and Nanda, I. and Evangelou, K. and Nikolova, T. and Horn, V. and Sagar, and Erny, D. and Stefanowski, J. and Rogell, L. and Klein, C. and Gharun, K. and Follo, M. and Seidl, M. and Kremer, B. and Münke, N. and Senges, J. and Fliegauf, M. and Aschman, T. and Pfeifer, D. and Sarrazin, S. and Sieweke, M.H. and Wagner, D. and Dierks, C. and Haaf, T. and Ness, T. and Zaiss, M.M. and Voll, R.E. and Deshmukh, S.D. and Prinz, M. and Goldmann, T. and Hölscher, C. and Hauser, A.E. and Lopez-Contreras, A.J. and Grün, D. and Gorgoulis, V. and Diefenbach, A. and Henneke, P. and Triantafyllopoulou, A.
Cell 167 (5): 1264-1280. 17 November 2016

Detection of signature volatiles for cariogenic microorganisms.
Hertel, M. and Preissner, R. and Gillissen, B. and Schmidt-Westhausen, A.M. and Paris, S. and Preissner, S.
European Journal of Clinical Microbiology & Infectious Diseases 35 (2): 235-244. February 2016

Super-resolution ribosome profiling reveals unannotated translation events in Arabidopsis.
Hsu, P.Y. and Calviello, L. and Wu, H.Y.L. and Li, F.W. and Rothfels, C.J. and Ohler, U. and Benfey, P.N.
Proceedings of the National Academy of Sciences of the United States of America 113 (45): E7126-E7135. 8 November 2016

Delivery of therapeutics targeting the mRNA-binding protein HuR using 3DNA nanocarriers suppresses ovarian tumor growth.
Huang, Y.H. and Peng, W. and Furuuchi, N. and Gerhart, J. and Rhodes, K. and Mukherjee, N. and Jimbo, M. and Gonye, G.E. and Brody, J.R. and Getts, R.C. and Sawicki, J.A.
Cancer Research 76 (6): 1549-1559. 15 March 2016

MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer.
Ilm, K. and Fuchs, S. and Mudduluru, G. and Stein, U.
Oncotarget 7 (33): 53443-53458. 16 August 2016

Automated annotation and evaluation of in-source mass spectra in GC/atmospheric pressure chemical ionization-MS-based metabolomics.
Jaeger, C. and Hoffmann, F. and Schmitt, C.A. and Lisec, J.
Analytical Chemistry 88 (19): 9386-9390. 4 October 2016

Longitudinal study to assess the clinical significance of MSI2 expression in chronic myeloid keukemia patients.
Kaeda, J. and Ringel, F. and Oberender, C. and Gresse, M. and Amini, L. and Schwarz, M. and Doerken, B. and le Coutre, P.
Acta Haematologica 136 (1): 62-64. June 2016

Genome wide conditional mouse knockout resources.
Kaloff, C. and Anastassiadis, K. and Ayadi, A. and Baldock, R. and Beig, J. and Birling, M.C. and Bradley, A. and Brown, S.D.M. and Buerger, A. and Bushell, W. and Chiani, F. and Collins, F.S. and Doe, B. and Eppig, J.T. and Finnell, R.H. and Fletcher, C. and Flicek, P. and Fray, M. and Friedel, R.H. and Gambadoro, A. and Gates, H. and Hansen, J. and Herault, Y. and Hicks, G.G. and Hoerlein, A. and Hrabe de Angelis, M. and Iyer, V. and de Jong, P.J. and Koscielny, G. and Kuehn, R. and Liu, P. and Lloyd, K.C.K and Lopez, R.G. and Marschall, S. and Martinez, S. and McKerlie, C. and Meehan, T. and von Melchner, H. and Moore, M. and Murray, S.A. and Nagy, A. and Nutter, L.M.J. and Pavlovic, G. and Pombero, A. and Prosser, H. and Ramirez-Solis, R. and Ringwald, M. and Rosen, B. and Rosenthal, N. and Rossant, J. and Ruiz Noppinger, P. and Ryder, E. and Skarnes, W.C. and Schick, J. and Schnuetgen, F. and Schofield, P. and Seisenberger, C. and Selloum, M. and Smedley, D. and Simpson, E.M. and Stewart, A.F. and Teboul, L. and Tocchini Valentini, G.P. and Valenzuela, D. and West, A.P. and Wurst, W.
Drug Discovery Today: Disease Models 20 : 3-12. 2016

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
Kandalla, P.K. and Sarrazin, S. and Molawi, K. and Berruyer, C. and Redelberger, D. and Favel, A. and Bordi, C. and de Bentzmann, S. and Sieweke, M.H.
Journal of Experimental Medicine 213 (11): 2269-2279. 10 October 2016

Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
Kang, Y. and Gohlke, U. and Engström, O. and Hamark, C. and Scheidt, T. and Kunstmann, S. and Heinemann, U. and Widmalm, G. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 138 (29): 9109-9118. 27 July 2016

Cseq-simulator: a data simulator for CLIP-Seq experiments.
Kassuhn, W. and Ohler, U. and Drewe, P.
In: Pacific Symposium on Biocomputing (PSB) 2016, 4-8 Jan 2016, The Big Island of Hawaii, USA. January 2016

Regional regulation of filiform tongue papillae development by Ikkα/Irf6.
Kawasaki, M. and Kawasaki, K. and Oommen, S. and Blackburn, J. and Watanabe, M. and Nagai, T. and Kitamura, A. and Maeda, T. and Liu, B. and Schmidt-Ullrich, R. and Akiyama, T. and Inoue, J.I. and Hammond, N.L. and Sharpe, P.T. and Ohazama, A.
Developmental Dynamics 245 (9): 937-946. September 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. and Hilgenberg, E. and Stervbo, U. and Lampropoulou, V. and Shen, P. and Bunse, M. and Jaimes, Y. and Boudinot, P. and Radbruch, A. and Klemm, U. and Kühl, A.A. and Liblau, R. and Hoevelmeyer, N. and Anderton, S.M. and Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

B cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B cell lymphoma in mice.
Knittel, G. and Liedgens, P. and Korovkina, D. and Seeger, J.M. and Al-Baldawi, Y. and Al-Maarri, M. and Fritz, C. and Vlantis, K. and Bezhanova, S. and Scheel, A.H. and Wolz, O.O. and Reimann, M. and Möller, P. and López, C. and Schlesner, M. and Lohneis, P. and Weber, A.N.R. and Trümper, L. and Staudt, L.M. and Ortmann, M. and Pasparakis, M. and Siebert, R. and Schmitt, C.A. and Klatt, A.R. and Wunderlich, F.T. and Schäfer, S.C. and Persigehl, T. and Montesinos-Rongen, M. and Odenthal, M. and Büttner, R. and Frenzel, L.P. and Kashkar, H. and Reinhardt, H.C.
Blood 127 (22): 2732-2741. 2 June 2016

Phase II trial of temsirolimus for relapsed/refractory primary CNS lymphoma.
Korfel, A. and Schlegel, U. and Herrlinger, U. and Dreyling, M. and Schmidt, C. and von Baumgarten, L. and Pezzutto, A. and Grobosch, T. and Kebir, S. and Thiel, E. and Martus, P. and Kiewe, P.
Journal of Clinical Oncology 34 (15): 1757-1763. 20 May 2016

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.
Kowenz-Leutz, E. and Schuetz, A. and Liu, Q. and Knoblich, M. and Heinemann, U. and Leutz, A.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847. July 2016

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR.
Krause, C.J. and Popp, O. and Thirunarayanan, N. and Dittmar, G. and Lipp, M. and Mueller, G.
Oncotarget 7 (9): 10414-10432. 1 March 2016

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution.
Kruse, F. and Junker, J.P. and van Oudenaarden, A. and Bakkers, J.
Methods in Cell Biology 135 : 299-307. 2016

Neutropenic sepsis in the ICU: Outcome predictors in a two-phase model and microbiology findings.
Kruse, J.M. and Jenning, T. and Rademacher, S. and Arnold, R. and Schmitt, C.A. and Jörres, A. and Enghard, P. and Oppert, M.
Critical Care Research and Practice 2016 : 8137850. 2016

TALENs : Methods and Protocols.
Kuehn, R. and Wurst, W. and Wefers, B.
Methods in Molecular Biology, 1338 . Springer, New York. ISBN 978-1-4939-2931-3 2016

Divergent transcription and epigenetic directionality of human promoters.
Lacadie, S.A. and Ibrahim, M.M. and Gokhale, S.A. and Ohler, U.
FEBS Journal 283 (23): 4214-4222. December 2016

A comprehensive comparison of general RNA-RNA interaction prediction methods.
Lai, D. and Meyer, I.M.
Nucleic Acids Research 44 (7): e61. 20 April 2016

Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation.
Leisegang, M. and Engels, B. and Schreiber, K. and Yew, P.Y. and Kiyotani, K. and Idel, C. and Arina, A. and Duraiswamy, J. and Weichselbaum, R.R. and Uckert, W. and Nakamura, Y. and Schreiber, H.
Clinical Cancer Research 22 (11): 2734-2743. 1 June 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. and Kammertoens, T. and Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

MACC1 induces tumor progression in transgenic mice and colorectal cancer patients via increased pluripotency markers Nanog and Oct4.
Lemos, C. and Hardt, M.S. and Juneja, M. and Voss, C. and Foerster, S. and Jerchow, B. and Haider, W. and Blaker, H. and Stein, U.
Clinical Cancer Research 22 (11): 2812-2824. 1 June 2016

Survival of Igα-deficient mature B cells requires BAFF-R function.
Levit-Zerdoun, E. and Becker, M. and Pohlmeyer, R. and Wilhelm, I. and Maity, P.C. and Rajewsky, K. and Reth, M. and Hobeika, E.
Journal of Immunology 196 (5): 2348-2360. 1 March 2016

High-resolution expression map of the arabidopsis root reveals alternative splicing and lincRNA regulation.
Li, S. and Yamada, M. and Han, X. and Ohler, U. and Benfey, P.N.
Developmental Cell 39 (4): 508-522. 21 November 2016

Lowered pH leads to fusion peptide release and a highly dynamic intermediate of influenza hemagglutinin.
Lin, X.C. and Noel, J.K. and Wang, Q.H. and Ma, J.P. and Onuchic, J.N.
Journal of Physical Chemistry B 120 (36): 9654-9660. 15 September 2016

Extending the dynamic range in metabolomics experiments by automatic correction of peaks exceeding the detection limit.
Lisec, J. and Hoffmann, F. and Schmitt, C. and Jaeger, C.
Analytical Chemistry 88 (15): 7487-7492. 2 August 2016

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D. and Pahuja, A. and Geers-Knörr, C. and Scheibe, R. and Nowak, M. and Hamati, J. and Köhncke, C. and Purfürst, B. and Kanashova, T. and Schmidt, S. and Glass, D.J. and Morano, I. and Heuser, A. and Kraft, T. and Bassel-Duby, R. and Olson, E.N. and Dittmar, G. and Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180. May 2016

Minichromosome maintenance complex is a critical node in the miR-183 signaling network of MYCN-amplified neuroblastoma cells.
Lodrini, M. and Poschmann, G. and Schmidt, V. and Wünschel, J. and Dreidax, D. and Witt, O. and Höfer, T. and Meyer, H.E. and Stühler, K. and Eggert, A. and Deubzer, H.E.
Journal of Proteome Research 15 (7): 2178-2186. 1 July 2016

Different promoter affinities account for specificity in MYC-dependent gene regulation.
Lorenzin, F. and Benary, U. and Baluapuri, A. and Walz, S. and Jung, L.A. and von Eyss, B. and Kisker, C. and Wolf, J. and Eilers, M. and Wolf, E.
eLife 5 : e15161. 27 July 2016

Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients.
Lu, H. and Busch, J. and Jung, M. and Rabenhorst, S. and Ralla, B. and Kilic, E. and Mergemeier, S. and Budach, N. and Fendler, A. and Jung, K.
Clinica Chimica Acta 452 : 109-119. 15 January 2016

Einfluss genetischer Varianten auf die humane Erythropoese [Influence of genetic variants on human erythropoiesis].
Ludwig, L.S.
BIOspektrum 22 (7): 768-769. November 2016

Emerging cellular and gene therapies for congenital anemias.
Ludwig, L.S. and Khajuria, R.K. and Sankaran, V.G.
American Journal of Medical Genetics C 172C (4): 332-348. 12 December 2016

Breaking TADs: how alterations of chromatin domains result in disease.
Lupiáñez, D.G. and Spielmann, M. and Mundlos, S.
Trends in Genetics 32 (4): 225-237. April 2016

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.
Mansouri, L. and Noerenberg, D. and Young, E. and Mylonas, E. and Abdulla, M. and Frick, M. and Asmar, F. and Ljungstroem, V. and Schneider, M. and Yoshida, K. and Skaftason, A. and Pandzic, T. and Gonzalez, B. and Tasidou, A. and Waldhueter, N. and Rivas-Delgado, A. and Angelopoulou, M. and Ziepert, M. and Arends, C.M. and Couronne, L. and Lenze, D. and Baldus, C.D. and Bastard, C. and Okosun, J. and Fitzgibbon, J. and Doerken, B. and Drexler, H.G. and Roos-Weil, D. and Schmitt, C.A. and Munch-Petersen, H.D. and Zenz, T. and Hansmann, M.L. and Strefford, J.C. and Enblad, G. and Bernard, O.A. and Ralfkiaer, E. and Erlanson, M. and Korkolopoulou, P. and Hultdin, M. and Papadaki, T. and Gronbaek, K. and Lopez-Guillermo, A. and Ogawa, S. and Kueppers, R. and Stamatopoulos, K. and Stavroyianni, N. and Kanellis, G. and Rosenwald, A. and Campo, E. and Amini, R.M. and Ott, G. and Vassilakopoulos, T.P. and Hummel, M. and Rosenquist, R. and Damm, F.
Blood 128 (23): 2666-2670. 15 December 2016

A complex water network contributes to high-affinity binding in an antibody-antigen interface.
Marino, S.F. and Olal, D. and Daumke, O.
Data in Brief 6 : 394-397. March 2016

Tubular epithelial NF-κB activity regulates ischemic AKI.
Markó, L. and Vigolo, E. and Hinze, C. and Park, J.K. and Roël, G. and Balogh, A. and Choi, M. and Wübken, A. and Cording, J. and Blasig, I.E. and Luft, F.C. and Scheidereit, C. and Schmidt-Ott, K.M. and Schmidt-Ullrich, R. and Müller, D.N.
Journal of the American Society of Nephrology 27 (9): 2658-2669. September 2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O. and Winter, D.R. and Giladi, A. and Vargas Aguilar, S. and Spinrad, A. and Sarrazin, S. and Ben-Yehuda, H. and David, E. and Zelada González, F. and Perrin, P. and Keren-Shaul, H. and Gury, M. and Lara-Astaiso, D. and Thaiss, C.A. and Cohen, M. and Bahar Halpern, K. and Baruch, K. and Deczkowska, A. and Lorenzo-Vivas, E. and Itzkovitz, S. and Elinav, E. and Sieweke, M.H. and Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

Hodgkin lymphoma: pathology and biology.
Mathas, S. and Hartmann, S. and Küppers, R.
Seminars in Hematology 53 (3): 139-147. July 2016

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.
Mensali, N. and Ying, F. and Sheng, V.O.Y. and Yang, W. and Walseng, E. and Kumari, S. and Fallang, L.E. and Kolstad, A. and Uckert, W. and Malmberg, K.J. and Waelchli, S. and Olweus, J.
OncoImmunology 5 (5): e1138199. 18 February 2016

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
Moenke, G. and Cristiano, E. and Finzel, A. and Friedrich, D. and Herzel, H. and Falcke, M. and Loewer, A.
bioRxiv : 068668. 28 November 2016

Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.
Momeny, M. and Ghasemi, R. and Valenti, G. and Miranda, M. and Zekri, A. and Zarrinrad, G. and Javadikooshesh, S. and Yaghmaie, M. and Alimoghaddam, K. and Ghavamzadeh, A. and Ghaffari, S.H.
Tumor Biology 37 (3): 3913-3923. March 2016

Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets.
Mudduluru, G. and Walther, W. and Kobelt, D. and Dahlmann, M. and Treese, C. and Assaraf, Y.G. and Stein, U.
Drug Resistance Updates 26 : 10-27. May 2016

Integrative classification of human coding and non-coding genes based on RNA metabolism profiles.
Mukherjee, N. and Calviello, L. and Hirsekorn, A. and de Pretis, S. and Pelizzola, M. and Ohler, U.
bioRxiv : 073643. 6 September 2016

Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter - AWMF-Registernummer 057-016 [Diagnosis, therapy and follow-up of diabetes mellitus in children and adolescents - AWMF-Registry-Number 057-016].
Neu, A. and Buerger-Buesing, J. and Danne, T. and Dost, A. and Holder, M. and Holl, R.W. and Holterhus, P.M. and Kapellen, T. and Karges, B. and Kordonouri, O. and Mueller, S. and Raile, K. and Schweizer, R. and von Sengbusch, S. and Stachow, R. and Wagner, V. and Wiegand, S. and Ziegler, R.
Diabetologie und Stoffwechsel 11 (1): 35-94. 25 February 2016

BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.
Neuendorff, N.R. and Burmeister, T. and Doerken, B. and Westermann, J.
Annals of Hematology 95 (8): 1211-1221. August 2016

CCL4 as an adjuvant for DNA vaccination in a Her2/neu mouse tumor model.
Nguyen-Hoai, T. and Pham-Duc, M. and Gries, M. and Dörken, B. and Pezzutto, A. and Westermann, J.
Cancer Gene Therapy 23 (6): 162-167. June 2016

SMOG 2: A versatile software package for generating structure-based models.
Noel, J.K. and Levi, M. and Raghunathan, M. and Lammert, H. and Hayes, R.L. and Onuchic, J.N. and Whitford, P.C.
PLoS Computational Biology 12 (3): e1004794. 10 March 2016

Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamics.
Noel, J.K. and Morcos, F. and Onuchic, J.N.
F1000 Research 5 (F1000 Faculty Rev): 106. 26 January 2016

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
Noel, J.K. and Whitford, P.C.
Nature Communications 7 : 13314. 31 October 2016

Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation.
Olal, D. and Daumke, O.
Cell Reports 14 (9): 2092-2099. 8 March 2016

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.
Orlanski, S. and Labi, V. and Reizel, Y. and Spiro, A. and Lichtenstein, M. and Levin-Klein, R. and Koralov, S.B. and Skversky, Y. and Rajewsky, K. and Cedar, H. and Bergman, Y.
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5018-5023. 3 May 2016

Improved treatment of MT-3 breast cancer and brain metastases in a mouse xenograft by LRP-targeted oxaliplatin liposomes.
Orthmann, A. and Peiker, L. and Fichtner, I. and Hoffmann, A. and Hilger, R.A. and Zeisig, R.
Journal of Biomedical Nanotechnology 12 (1): 56-68. January 2016

Vectors and strategies for nonviral cancer gene therapy.
Pahle, J. and Walther, W.
Expert Opinion on Biological Therapy 16 (4): 443-461. April 2016

Bacterial toxins for oncoleaking suicidal cancer gene therapy.
Pahle, J. and Walther, W.
Recent Results in Cancer Research 209 : 95-110. 2016

A complex of Htm1 and the oxidoreductase Pdi1 accelerates degradation of misfolded glycoproteins.
Pfeiffer, A. and Stephanowitz, H. and Krause, E. and Volkwein, C. and Hirsch, C. and Jarosch, E. and Sommer, T.
Journal of Biological Chemistry 291 (23): 12195-12207. 3 June 2016

Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice.
Poppenborg, S.M. and Wittmann, J. and Walther, W. and Brandenburg, G. and Kraehmer, R. and Baumgart, J. and Leenders, F.
European Journal of Pharmaceutical Sciences 91 : 122-130. 25 August 2016

Direct chromosome-length haplotyping by single-cell sequencing.
Porubský, D. and Sanders, A.D. and van Wietmarschen, N. and Falconer, E. and Hills, M. and Spierings, D.C.J. and Bevova, M.R. and Guryev, V. and Lansdorp, P.M.
Genome Research 26 (11): 1565-1574. November 2016

Immune modulation and prevention of autoimmune disease by repeated sequences from parasites linked to self antigens.
Puentes, F. and Dickhaut, K. and Hofstaetter, M. and Pfeil, J. and Lauer, U. and Hamann, A. and Hoffmann, U. and Falk, K. and Roetzschke, O.
Journal of Neuroimmune Pharmacology 11 (4): 749-762. December 2016

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J. and Yu, Y. and Akilli Öztürk, Ö. and Holland, J.D. and Besser, D. and Fritzmann, J. and Wulf-Goldenberg, A. and Eckert, K. and Fichtner, I. and Birchmeier, W.
Gut 65 (10): 1690-1701. October 2016

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.
Regalo, G. and Förster, S. and Resende, C. and Bauer, B. and Fleige, B. and Kemmner, W. and Schlag, P.M. and Meyer, T.F. and Machado, J.C. and Leutz, A.
Journal of Molecular Medicine 94 (12): 1385-1395. December 2016

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M. and Saydaminova, K. and Yumul, R. and Krishnan, R. and Liu, J. and Nagy, E.E. and Singh, M. and Izsvák, Z. and Cattaneo, R. and Uckert, W. and Palmer, D. and Ng, P. and Haworth, K.G. and Kiem, H.P. and Ehrhardt, A. and Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors.
Riemke, P. and Czeh, M. and Fischer, J. and Walter, C. and Ghani, S. and Zepper, M. and Agelopoulos, K. and Lettermann, S. and Gebhardt, M.L. and Mah, N. and Weilemann, A. and Grau, M. and Groening, V. and Haferlach, T. and Lenze, D. and Delwel, R. and Prinz, M. and Andrade-Navarro, M.A. and Lenz, G. and Dugas, M. and Mueller-Tidow, C. and Rosenbauer, F.
EMBO Journal 35 (22): 2399-2416. 15 November 2016

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
Roest, H.L. and Sachsenberg, T. and Aiche, S. and Bielow, C. and Weisser, H. and Aicheler, F. and Andreotti, S. and Ehrlich, H.C. and Gutenbrunner, P. and Kenar, E. and Liang, X. and Nahnsen, S. and Nilse, L. and Pfeuffer, J. and Rosenberger, G. and Rurik, M. and Schmitt, U. and Veit, J. and Walzer, M. and Wojnar, D. and Wolski, W.E. and Schilling, O. and Choudhary, J.S. and Malmstroem, L. and Aebersold, R. and Reinert, K. and Kohlbacher, O.
Nature Methods 13 (9): 741-748. September 2016

Characterizing polymorphic inversions in human genomes by single-cell sequencing.
Sanders, A.D. and Hills, M. and Porubský, D. and Guryev, V. and Falconer, E. and Lansdorp, P.M.
Genome Research 26 (11): 1575-1587. November 2016

Eosinophils and mast cells: a lineage apart.
Sarrazin, S. and Sieweke, M.H.
Nature Immunology 17 (6): 609-611. 19 May 2016

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
Schirmer, D. and Grünewald, T.G.P. and Klar, R. and Schmidt, O. and Wohlleber, D. and Rubio, R.A. and Uckert, W. and Thiel, U. and Bohne, F. and Busch, D.H. and Krackhardt, A.M. and Burdach, S. and Richter, G.H.S.
OncoImmunology 5 (6): e1175795. 25 April 2016

SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.
Schmid, F. and Wang, Q. and Huska, M.R. and Andrade-Navarro, M.A. and Lemm, M. and Fichtner, I. and Dahlmann, M. and Kobelt, D. and Walther, W. and Smith, J. and Schlag, P.M. and Stein, U.
Oncogene 35 (46): 5942-5952. 17 November 2016

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Amirabad, A.D. and Ardakani, F.B. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
bioRxiv : 081935. 19 October 2016

The persistent dynamic secrets of senescence.
Schmitt, C.A.
Nature Cell Biology 18 (9): 913-915. September 2016

ANCA-associated vasculitis and the mechanisms of tissue injury.
Schreiber, A. and Choi, M.
In: Systemic Vasculitides: Current Status and Perspectives. Springer International Publishing, Switzerland, 141-158. ISBN 978-3-319-40134-8 14 October 2016

The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion.
Schulte, K. and Pawlowski, N. and Faelber, K. and Fröhlich, C. and Howard, J. and Daumke, O.
BMC Biology 14 (1): 14. 2 March 2016

ALVIS: interactive non-aggregative visualization and explorative analysis of multiple sequence alignments.
Schwarz, R.F. and Tamuri, A.U. and Kultys, M. and King, J. and Godwin, J. and Florescu, A.M. and Schultz, J. and Goldman, N.
Nucleic Acids Research 44 (8): e77. 5 May 2016

Myc depletion induces a pluripotent dormant state mimicking diapause.
Scognamiglio, R. and Cabezas-Wallscheid, N. and Thier, M.C. and Altamura, S. and Reyes, A. and Prendergast, Á.M. and Baumgärtner, D. and Carnevalli, L.S. and Atzberger, Ann and Haas, S. and von Paleske, L. and Boroviak, T. and Wörsdörfer, P. and Essers, M.A.G. and Kloz, U. and Eisenman, R.N. and Edenhofer, F. and Bertone, P. and Huber, W. and van der Hoeven, F. and Smith, A. and Trumpp, A.
Cell 164 (4): 668-680. 11 February 2016

Polycomb repressive complex 2 is a barrier to KRAS-driven inflammation and epithelial-mesenchymal transition in non-small-cell lung cancer.
Serresi, M. and Gargiulo, G. and Proost, N. and Siteur, B. and Cesaroni, M. and Koppens, M. and Xie, H. and Sutherland, K.D. and Hulsman, D. and Citterio, E. and Orkin, S. and Berns, A. and van Lohuizen, M.
Cancer Cell 29 (1): 17-31. 11 January 2016

TAK1 adaptor proteins TAB2 and TAB3 link the sign