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Stat3 activation is required for cellular transformation by v-src

Item Type:Article
Title:Stat3 activation is required for cellular transformation by v-src
Creators Name:Bromberg, J.F., Horvath, C.M., Besser, D., Lathem, W.W. and Darnell, J.E.
Abstract:Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.
Keywords:3T3 Cells, Cell Survival, Neoplastic Cell Transformation, DNA-Binding Proteins, Neoplastic Gene Expression Regulation, Oncogene Protein pp60(v-src), STAT3 Transcription Factor, Stem Cells, Trans-Activators, Animals, Mice
Source:Molecular and Cellular Biology
Publisher:American Society for Microbiology
Page Range:2553-2558
Date:May 1998
Official Publication:http://mcb.asm.org/cgi/content/abstract/18/5/2553
PubMed:View item in PubMed

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