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PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Oxidative metabolism drives immortalization of neural stem cells during tumorigenesis.
Bonnay, F. and Veloso, A. and Steinmann, V. and Köcher, T. and Abdusselamoglu, M.D. and Bajaj, S. and Rivelles, E. and Landskron, L. and Esterbauer, H. and Zinzen, R.P. and Knoblich, J.A.
Cell 10 September 2020 (In Press)

LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N. and Almouzni, G. and Gorski, S.A. and Aerts, S. and Amit, I. and Bertero, M.G. and Bock, C. and Bredenoord, A.L. and Cavalli, G. and Chiocca, S. and Clevers, H. and De Strooper, B. and Eggert, A. and Ellenberg, J. and Fernández, X.M. and Figlerowicz, M. and Gasser, S.M. and Hubner, N. and Kjems, J. and Knoblich, J.A. and Krabbe, G. and Lichter, P. and Linnarsson, S. and Marine, J.C. and Marioni, J. and Marti-Renom, M.A. and Netea, M.G. and Nickel, D. and Nollmann, M. and Novak, H.R. and Parkinson, H. and Piccolo, S. and Pinheiro, I. and Pombo, A. and Popp, C. and Reik, W. and Roman-Roman, S. and Rosenstiel, P. and Schultze, J.L. and Stegle, O. and Tanay, A. and Testa, G. and Thanos, D. and Theis, F.J. and Torres-Padilla, M.E. and Valencia, A. and Vallot, C. and van Oudenaarden, A. and Vidal, M. and Voet, T.
Nature 7 September 2020 (In Press)

VPS10P domain receptors: sorting out brain health and disease.
Malik, A.R. and Willnow, T.E.
Trends in Neurosciences 4 September 2020 (In Press)

Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W. and Shang, F. and Wang, X. and Fanti, A.K. and Greco, A. and Busch, K. and Klapproth, K. and Zhang, Q. and Quedenau, C. and Sauer, S. and Feyerabend, T.B. and Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27 (3): 383-395. 3 September 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K. and Lim, E.L. and Petkovic, M. and Elizalde, S. and Birkbak, N.J. and Wilson, G.A. and Moore, D.A. and Grönroos, E. and Rowan, A. and Dewhurst, S.M. and Demeulemeester, J. and Dentro, S.C. and Horswell, S. and Au, L. and Haase, K. and Escudero, M. and Rosenthal, R. and Bakir, M.A. and Xu, H. and Litchfield, K. and Lu, W.T. and Mourikis, T.P. and Dietzen, M. and Spain, L. and Cresswell, G.D. and Biswas, D. and Lamy, P. and Nordentoft, I. and Harbst, K. and Castro-Giner, F. and Yates, L.R. and Caramia, F. and Jaulin, F. and Vicier, C. and Tomlinson, I.P.M. and Brastianos, P.K. and Cho, R.J. and Bastian, B.C. and Dyrskjøt, L. and Jönsson, G.B. and Savas, P. and Loi, S. and Campbell, P.J. and Andre, F. and Luscombe, N.M. and Steeghs, N. and Tjan-Heijnen, V.C.G. and Szallasi, Z. and Turajlic, S. and Jamal-Hanjani, M. and Van Loo, P. and Bakhoum, S.F. and Schwarz, R.F. and McGranahan, N. and Swanton, C.
Nature 2 September 2020 (In Press)

Blood pressure and angiogenic markers in pregnancy: contributors to pregnancy-induced hypertension and offspring cardiovascular risk.
Birukov, A.. and Herse, F. and Nielsen, J.H. and Kyhl, H.B. and Golic, M. and Kräker, K. and Haase, N. and Busjahn, A. and Bruun, S. and Jensen, B.L. and Müller, D.N. and Jensen, T.K. and Christesen, H.T. and Andersen, M.S. and Jørgensen, J.S. and Dechend, R. and Andersen, L.B.
Hypertension 76 (3): 901-909. September 2020

Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. and Isbilir, A. and Sungkaworn, T. and Osberg, B. and Karathanasis, C. and Sunkara, V. and Grushevskyi, E.O. and Bock, A. and Annibale, P. and Heilemann, M. and Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16 (9): 946-954. September 2020

Diversity within species: interpreting strains in microbiomes.
Van Rossum, T. and Ferretti, P. and Maistrenko, O.M. and Bork, P.
Nature Reviews Microbiology 18 : 491-506. September 2020

A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C. and Mueller, L. and Ruzittu, S. and Mah, N. and Willnow, D. and Darrigrand, J.F. and Wilson, H. and Khosravinia, D. and Mahmoud, A.A. and Risolino, M. and Selleri, L. and Spagnoli, F.M.
Developmental Cell 27 August 2020 (In Press)

Optical mapping of cAMP signaling at the nanometer scale.
Bock, A. and Annibale, P. and Konrad, C. and Hannawacker, A. and Anton, S.E. and Maiellaro, I. and Zabel, U. and Sivaramakrishnan, S. and Falcke, M. and Lohse, M.J.
Cell 25 August 2020 (In Press)

Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling.
Zhang, J.Z. and Lu, T.W. and Stolerman, L.M. and Tenner, B. and Yang, J.R. and Zhang, J.F. and Falcke, M. and Rangamani, P. and Taylor, S.S. and Mehta, S. and Zhang, J.
Cell 25 August 2020 (In Press)

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I. and Beaton, N. and Bruderer, R. and Knobloch, T. and Barbisan, C. and Chandat, L. and Sudau, A. and Siepe, I. and Rinner, O. and de Souza, N. and Picotti, P. and Reiter, L.
Nature Communications 11 (1): 4200. 21 August 2020

S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants.
Willers, M. and Ulas, T. and Völlger, L. and Vogl, T. and Heinemann, A.S. and Pirr, S. and Pagel, J. and Fehlhaber, B. and Halle, O. and Schöning, J. and Schreek, S. and Löber, U. and Essex, M. and Hombach, P. and Graspeuntner, S. and Basic, M. and Bleich, A. and Cloppenborg-Schmidt, K. and Künzel, S. and Jonigk, D. and Rupp, J. and Hansen, G. and Förster, R. and Baines, J.F. and Härtel, C. and Schultze, J.L. and Forslund, S.K. and Roth, J. and Viemann, D.
Gastroenterology 15 August 2020 (In Press)

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L. and Panayotis, N. and Alber, S. and Dagan, S.Y. and Okladnikov, N. and Koppel, I. and Di Pizio, A. and Song, D.A. and Tzur, Y. and Terenzio, M. and Rishal, I. and Gordon, D. and Rother, F. and Hartmann, E. and Bader, M. and Fainzilber, M.
Science 369 (6505): 842-846. 14 August 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L. and Klaus, A. and Maas, J. and Morin-Poulard, I. and Weijts, B. and Schulte-Merker, S. and Berezikov, E. and Junker, J.P. and Robin, C.
Blood 136 (7): 831-844. 13 August 2020

Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D. and Ameen, M. and Guo, H. and Abilez, O.J. and Tian, L. and Mumbach, M.R. and Diecke, S. and Qin, X. and Liu, Y. and Yang, H. and Ma, N. and Gaddam, S. and Cunningham, N.J. and Gu, M. and Neofytou, E. and Prado, M. and Hildebrandt, T.B. and Karakikes, I. and Chang, H.Y. and Wu, J.C.
Developmental Cell 6 August 2020 (In Press)

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 5 August 2020 (In Press)

Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L. and Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27 (8): 717-725. August 2020

Tara Oceans: towards global ocean ecosystems biology.
Sunagawa, S. and Acinas, S.G. and Bork, P. and Bowler, C. and Eveillard, D. and Gorsky, G. and Guidi, L. and Iudicone, D. and Karsenti, E. and Lombard, F. and Ogata, H. and Pesant, S. and Sullivan, M.B. and Wincker, P. and de Vargas, C.
Nature Reviews Microbiology 18 (8): 428-445. August 2020

Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M. and Ferreira, D.G. and Batalha, V.L. and Marques-Morgado, I. and Coelho, J.E. and Pereira, P. and Gomes, R. and Pinto, A. and Carvalho, S. and Canas, P.M. and Cuvelier, L. and Buée-Scherrer, V. and Faivre, E. and Baqi, Y. and Müller, C.E. and Pimentel, J. and Schiffmann, S.N. and Buée, L. and Bader, M. and Outeiro, T.F. and Blum, D. and Cunha, R.A. and Marie, H. and Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25 (8): 1876-1900. August 2020

SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N. and Taberner, F.J. and Rangel Rojas, D. and Moroni, M. and Omberbasic, D. and Njoo, C. and Andrieux, A. and Gupta, P. and Bali, K.K. and Herpel, E. and Faghihi, F. and Fleming, T. and Dejean, A. and Lechner, S.G. and Nawroth, P.P. and Lewin, G.R. and Kuner, R.
Neuron 30 July 2020 (In Press)

Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
Preussner, M. and Gao, Q. and Morrison, E. and Herdt, O. and Finkernagel, F. and Schumann, M. and Krause, E. and Freund, C. and Chen, W. and Heyd, F.
Genome Biology 21 (1): 186. 29 July 2020

mRNAs, proteins and the emerging principles of gene expression control.
Buccitelli, C. and Selbach, M.
Nature Reviews Genetics 24 July 2020 (In Press)

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K. and Kase, J. and Dörr, J.R. and Trescher, S. and Bhattacharya, A. and Yu, Y. and Wailes, E.M. and Fan, D.N.Y. and Lohneis, P. and Milanovic, M. and Lau, A. and Lenze, D. and Hummel, M. and Chapuy, B. and Leser, U. and Reimann, M. and Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M. and Markó, L. and Schächterle, C. and Tsvetkov, D. and Cui, Y. and Maghsodi, S. and Bartolomaeus, T.U.P. and Maass, P.G. and Zühlke, K. and Gregersen, N. and Hübner, N. and Hodge, R. and Mühl, A. and Pohl, B. and Molé-Illas, R. and Geelhaar, A. and Walter, S. and Napieczynska, H. and Schelenz, S. and Taube, M. and Heuser, A. and Anistan, Y.M. and Qadri, F. and Todiras, M. and Plehm, R. and Popova, E. and Langanki, R. and Eichhorst, J. and Lehmann, M. and Wiesner, B. and Russwurm, M. and Forslund, S.K. and Kamer, I. and Müller, D.N. and Gollasch, M. and Aydin, A. and Bähring, S. and Bader, M. and Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 7 July 2020 (In Press)

Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U. and Kleinsorge, M. and Roos, L. and Yigit, G. and Li, Y. and Barbarics, B. and El-Battrawy, I. and Lan, H. and Tiburcy, M. and Hindmarsh, R. and Lenz, C. and Salinas, G. and Diecke, S. and Müller, C. and Adham, I. and Altmüller, J. and Nürnberg, P. and Paul, T. and Zimmermann, W.H. and Hasenfuss, G. and Wollnik, B. and Cyganek, L.
Circulation 6 July 2020 (In Press)

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
Toboso-Navasa, A. and Gunawan, A. and Morlino, G. and Nakagawa, R. and Taddei, A. and Damry, D. and Patel, Y. and Chakravarty, P. and Janz, M. and Kassiotis, G. and Brink, R. and Eilers, M. and Calado, D.P.
Journal of Experimental Medicine 217 (7): e20191933. 6 July 2020

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
Conte, M. and Fiorillo, L. and Bianco, S. and Chiariello, A.M. and Esposito, A. and Nicodemi, M.
Nature Communications 11 (1): 3289. 3 July 2020

VarFish: comprehensive DNA variant analysis for diagnostics and research.
Holtgrewe, M. and Stolpe, O. and Nieminen, M. and Mundlos, S. and Knaus, A. and Kornak, U. and Seelow, D. and Segebrecht, L. and Spielmann, M. and Fischer-Zirnsak, B. and Boschann, F. and Scholl, U. and Ehmke, N. and Beule, D.
Nucleic Acids Research 48 (W1): W162-W169. 2 July 2020

AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I. and Roux, P.F. and de Freitas, J.A.N.L.F. and Robinson, L. and Doré, G. and Sun, B. and Belenki, D. and Milanovic, M. and Herbig, U. and Schmitt, C.A. and Gil, J. and Bischof, O.
Nature Cell Biology 22 (7): 842-855. July 2020

Functional annotation of human long noncoding RNAs via molecular phenotyping.
Ramilowski, J.A. and Yip, C.W. and Agrawal, S. and Chang, J.C. and Ciani, Y. and Kulakovskiy, I.V. and Mendez, M. and Ooi, J.L.C. and Ouyang, J.F. and Parkinson, N. and Petri, A. and Roos, L. and Severin, J. and Yasuzawa, K. and Abugessaisa, I. and Akalin, A. and Antonov, I.V. and Arner, E. and Bonetti, A. and Bono, H. and Borsari, B. and Brombacher, F. and Cameron, C.J.F. and Cannistraci, C.V. and Cardenas, R. and Cardon, M. and Chang, H. and Dostie, J. and Ducoli, L. and Favorov, A. and Fort, A. and Garrido, D. and Gil, N. and Gimenez, J. and Guler, R. and Handoko, L. and Harshbarger, J. and Hasegawa, A. and Hasegawa, Y. and Hashimoto, K. and Hayatsu, N. and Heutink, P. and Hirose, T. and Imada, E.L. and Itoh, M. and Kaczkowski, B. and Kanhere, A. and Kawabata, E. and Kawaji, H. and Kawashima, T. and Kelly, S.T. and Kojima, M. and Kondo, N. and Koseki, H. and Kouno, T. and Kratz, A. and Kurowska-Stolarska, M. and Kwon, A.T.J. and Leek, J. and Lennartsson, A. and Lizio, M. and López-Redondo, F. and Luginbühl, J. and Maeda, S. and Makeev, V.J. and Marchionni, L. and Medvedeva, Y.A. and Minoda, A. and Müller, F. and Muñoz-Aguirre, M. and Murata, M. and Nishiyori, H. and Nitta, K.R. and Noguchi, S. and Noro, Y. and Nurtdinov, R. and Okazaki, Y. and Orlando, V. and Paquette, D. and Parr, C.J.C. and Rackham, O.J.L. and Rizzu, P. and Sánchez Martinez, D.F. and Sandelin, A. and Sanjana, P. and Semple, C.A.M. and Shibayama, Y. and Sivaraman, D.M. and Suzuki, T. and Szumowski, S.C. and Tagami, M. and Taylor, M.S. and Terao, C. and Thodberg, M. and Thongjuea, S. and Tripathi, V. and Ulitsky, I. and Verardo, R. and Vorontsov, I.E. and Yamamoto, C. and Young, R.S. and Baillie, J.K. and Forrest, A.R.R. and Guigó, R. and Hoffman, M.M. and Hon, C.C. and Kasukawa, T. and Kauppinen, S. and Kere, J. and Lenhard, B. and Schneider, C. and Suzuki, H. and Yagi, K. and de Hoon, M.J.L. and Shin, J.W. and Carninci, P.
Genome Research 30 (7): 1060-1072. July 2020

Dynamic conjugate F-SHARP microscopy.
Papadopoulos, I.N. and Jouhanneau, J.S. and Takahashi, N. and Kaplan, D. and Larkum, M. and Poulet, J. and Judkewitz, B.
Light: Science & Applications 9 (1): 110. 30 June 2020

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A. and Carlo-Spiewok, A.S. and Malik, A.R. and Rothe, M. and Schipke, C.G. and Peters, O. and Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 25 June 2020 (In Press)

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F. and Fink, C. and Hüttemeister, J. and Kirchner, M. and Radke, M.H. and Lopez Carballo, J. and Wagner, E. and Kohl, T. and Lehnart, S.E. and Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M. and Fischer, A. and Goetzke, C.C. and Neumaier, H.L. and Sauter, M. and Kespohl, M. and Müller, A.M. and Meckes, C. and Salbach, C. and Schenk, M. and Heuser, A. and Landmesser, U. and Weiner, J. and Meder, B. and Lehmann, L. and Kratzer, A. and Klingel, K. and Katus, H.A. and Kaya, Z. and Beling, A.
Circulation 141 (23): 1885-1902. 9 June 2020

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M. and Alpaugh, M. and Sciacca, G. and Saint-Pierre, M. and Masnata, M. and Denis, H.L. and Lévesque, S.A. and Herrmann, F. and Bazenet, C. and Garneau, A.P. and Isenring, P. and Truant, R. and Oueslati, A. and Gould, P.V. and Ast, A. and Wanker, E.E. and Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 8 June 2020 (In Press)

The sensory coding of warm perception.
Paricio-Montesinos, R. and Schwaller, F. and Udhayachandran, A. and Rau, F. and Walcher, J. and Evangelista, R. and Vriens, J. and Voets, T. and Poulet, J.F.A. and Lewin, G.R.
Neuron 106 (5): 830-841. 3 June 2020

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N. and Foster, D.J. and Cunningham, M.W. and Bercher, J. and Nguyen, T. and Shulga-Morskaya, S. and Milstein, S. and Shaikh, S. and Rollins, J. and Golic, M. and Herse, F. and Kräker, K. and Bendix, I. and Serdar, M. and Napieczynska, H. and Heuser, A. and Gellhaus, A. and Thiele, K. and Wallukat, G. and Müller, D.N. and LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130 (6): 2928-2942. 1 June 2020

Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J. and Goergen, H. and Keller, U. and Meissner, J. and Ordemann, R. and Halbsguth, T.V. and Sasse, S. and Sökler, M. and Kerkhoff, A. and Mathas, S. and Hüttmann, A. and Bormann, M. and Zimmermann, A. and Mettler, J. and Fuchs, M. and von Tresckow, B. and Baues, C. and Rosenwald, A. and Klapper, W. and Kobe, C. and Borchmann, P. and Engert, A.
JAMA Oncology 6 (6): 872-880. June 2020 (In Press)

A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
Kaminski, M.M. and Alcantar, M.A. and Lape, I.T. and Greensmith, R. and Huske, A.C. and Valeri, J.A. and Marty, F.M. and Klämbt, V. and Azzi, J. and Akalin, E. and Riella, L.V. and Collins, J.J.
Nature Biomedical Engineering 4 (6): 601-609. June 2020

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E. and Lafzi, A. and Moutinho, C. and Ziegenhain, C. and McCarthy, D.J. and Álvarez-Varela, A. and Batlle, E. and Sagar, and Grün, D. and Lau, J.K. and Boutet, S.C. and Sanada, C. and Ooi, A. and Jones, R.C. and Kaihara, K. and Brampton, C. and Talaga, Y. and Sasagawa, Y. and Tanaka, K. and Hayashi, T. and Braeuning, C. and Fischer, C. and Sauer, S. and Trefzer, T. and Conrad, C. and Adiconis, X. and Nguyen, L.T. and Regev, A. and Levin, J.Z. and Parekh, S. and Janjic, A. and Wange, L.E. and Bagnoli, J.W. and Enard, W. and Gut, M. and Sandberg, R. and Nikaido, I. and Gut, I. and Stegle, O. and Heyn, H.
Nature Biotechnology 38 (6): 747-755. June 2020

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Uroda, T. and Chillón, I. and Annibale, P. and Teulon, J.M. and Pessey, O. and Karuppasamy, M. and Pellequer, J.L. and Marcia, M.
Nature Protocols 15 (6): 2107-2139. June 2020

GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G. and Custodio, J. and Kallas, T. and Agostini, F. and Wernersson, E. and Spanjaard, B. and Mota, A. and Kolbeinsdottir, S. and Gelali, E. and Crosetto, N. and Bienko, M.
Nature Biotechnology 25 May 2020 (In Press)

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Vieira-Silva, S. and Falony, G. and Belda, E. and Nielsen, T. and Aron-Wisnewsky, J. and Chakaroun, R. and Forslund, S.K. and Assmann, K. and Valles-Colomer, M. and Nguyen, T..D. and Proost, S. and Prifti, E. and Tremaroli, V. and Pons, N. and Le Chatelier, E. and Andreelli, F. and Bastard, J.P. and Coelho, L.P. and Galleron, N. and Hansen, T.H. and Hulot, J.S. and Lewinter, C. and Pedersen, H.K. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Søndertoft, N.B. and Touch, S. and Dumas, M.E. and Ehrlich, S.D. and Galan, P. and Gøtze, J.P. and Hansen, T. and Holst, J.J. and Køber, L. and Letunic, I. and Nielsen, J. and Oppert, J.M. and Stumvoll, M. and Vestergaard, H. and Zucker, J.D. and Bork, P. and Pedersen, O. and Bäckhed, F. and Clément, K. and Raes, J.
Nature 581 (7808): 310-315. 21 May 2020

Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C. and Chen, X. and Planells-Cases, R. and Chu, J. and Wang, L. and Cao, L. and Li, Z. and López-Cayuqueo, K.I. and Xie, Y. and Ye, S. and Wang, X. and Ullrich, F. and Ma, S. and Fang, Y. and Zhang, X. and Qian, Z. and Liang, X. and Cai, S.Q. and Jiang, Z. and Zhou, D. and Leng, Q. and Xiao, T.S. and Lan, K. and Yang, Ji. and Li, H. and Peng, C. and Qiu, Z. and Jentsch, T.J. and Xiao, H.
Immunity 52 (5): 767-781. 19 May 2020

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S. and Gimber, N. and Deuschel, D. and Stuhlmann, T. and Puchkov, D. and Farsi, Z. and Ludwig, C.F. and Novarino, G. and López-Cayuqueo, K.I. and Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39 (9): e103358. 4 May 2020

Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A. and Wiesemann, S. and Golic, M. and Balogh, A. and Marko, L. and Rakova, N. and Wilck, N. and Blaszczyk, E. and Lim, C. and Weiss, S. and Kräker, K. and Haase, N. and Frolova, A. and Jørgensen, J.S. and Daub, S. and Mueller, D.N. and Herse, F. and Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13 (5): 1291-1293. May 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. and Wagner, L.K. and Li, H. and Dörr, D. and Medaglia, C. and Paul, F. and Shemer, A. and Jung, S. and Yona, S. and Mack, M. and Leutz, A. and Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

The (pro)renin receptor: what's in a name?
Simons, M. and Bader, M. and Müller, D.N.
Nature Reviews Nephrology 16 (5): 304. May 2020

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Sungnak, W. and Huang, N. and Bécavin, C. and Berg, M. and Queen, R. and Litvinukova, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Sampaziotis, F. and Worlock, K.B. and Yoshida, M. and Barnes, J.L.
Nature Medicine 26 (5): 681-687. May 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A. and Kang, M.C. and Yang, W.M. and Hwang, W.M. and Kim, S.S. and Hong, S.H. and Heo, J.I. and Vijyakumar, A. and Pereira de Moura, L. and Uner, A. and Huang, H. and Lee, S.H. and Lima, I.S. and Park, K.S. and Kim, M.S. and Dagon, Y. and Willnow, T.E. and Aroda, V. and Ciaraldi, T.P. and Henry, R.R. and Kim, Y.B.
Nature Communications 11 (1): 2024. 24 April 2020

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N. and McKenzie, S. and Beed, P. and English, D.F. and Oldani, S. and Tukker, J.J. and Buzsáki, G. and Schmitz, D.
Nature Communications 11 (1): 1947. 23 April 2020

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M. and Ruiz-Orera, J. and Albà, M.M. and Eyras, E.
Nature Communications 11 (1): 1768. 14 April 2020

Methods for mapping 3D chromosome architecture.
Kempfer, R. and Pombo, A.
Nature Reviews Genetics 21 (4): 207-226. April 2020

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha, S. and Baurecht, H. and Novak, N. and Rodríguez, E. and Bej, S. and Mayr, G. and Emmert, H. and Stölzl, D. and Gerdes, S. and Degenhardt, F. and Hübenthal, M. and Ellinghaus, E. and Jung, E.S. and Kässens, J.C. and Wienbrandt, L. and Lieb, W. and Müller-Nurasyid, M. and Hotze, M. and Dand, N. and Grosche, S. and Marenholz, I. and Arnold, A. and Homuth, G. and Schmidt, C.O. and Wehkamp, U. and Nöthen, M.M. and Hoffmann, P. and Paternoster, L. and Standl, M. and Bønnelykke, K. and Ahluwalia, T.S. and Bisgaard, H. and Peters, A. and Gieger, C. and Waldenberger, M. and Schulz, H. and Strauch, K. and Werfel, T. and Lee, Y.A. and Wolfien, M. and Rosenstiel, P. and Wolkenhauer, O. and Schreiber, St. and Franke, A. and Weidinger, S. and Ellinghaus, D.
Journal of Allergy and Clinical Immunology 145 (4): 1208-1218. April 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G. and Roeschert, I. and Prinz, F. and Baluapuri, A. and Silveira Vidal, R. and Schülein-Völk, C. and Chang, Y.C. and Ade, C.P. and Mastrobuoni, G. and Girard, C. and Wortmann, L. and Walz, S. and Lührmann, R. and Kempa, S. and Kuster, B. and Wolf, E. and Mumberg, D. and Eilers, M.
Molecular Cell 77 (6): 1322-1339. 19 March 2020

Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A. and Gisevius, B. and Hirschberg, S. and Yissachar, N. and Stangl, G.I. and Eilers, E. and Bader, V. and Haase, S. and Kaisler, J. and David, C. and Schneider, R. and Troisi, R. and Zent, D. and Hegelmaier, T. and Dokalis, N. and Gerstein, S. and Del Mare-Roumani, S. and Amidror, S. and Staszewski, O. and Poschmann, G. and Stühler, K. and Hirche, F. and Balogh, A. and Kempa, S. and Träger, P. and Zaiss, M.M. and Holm, J.B. and Massa, M.G. and Nielsen, H.B. and Faissner, A. and Lukas, C. and Gatermann, S.G. and Scholz, M. and Przuntek, H. and Prinz, M. and Forslund, S.K. and Winklhofer, K.F. and Müller, D.N. and Linker, R.A. and Gold, R. and Haghikia, A.
Cell 180 (6): 1067-1080. 19 March 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C. and Müller, M. and Pak, H.S. and Harnett, D. and Huber, F. and Grun, D. and Leleu, M. and Auger, A. and Arnaud, M. and Stevenson, B.J. and Michaux, J. and Bilic, I. and Hirsekorn, A. and Calviello, L. and Simó-Riudalbas, L. and Planet, E. and Lubiński, J. and Bryśkiewicz, M. and Wiznerowicz, M. and Xenarios, I. and Zhang, L. and Trono, D. and Harari, A. and Ohler, U. and Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11 (1): 1293. 10 March 2020

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K. and Jung, M. and Foinquinos, A. and San José, G. and Beaumont, J. and Bock, K. and Grote-Levi, L. and Xiao, K. and Bär, C. and Pfanne, A. and Just, A. and Zimmer, K. and Ngoy, S. and López, B. and Ravassa, S. and Samolovac, S. and Janssen-Peters, H. and Remke, J. and Scherf, K. and Dangwal, S. and Piccoli, M.T. and Kleemiss, F. and Kreutzer, F.P. and Kenneweg, F. and Leonardy, J. and Hobuß, L. and Santer, L. and Do, Q.T. and Geffers, R. and Braesen, J.H. and Schmitz, J. and Brandenberger, C. and Müller, D.N. and Wilck, N. and Kaever, V. and Bähre, H. and Batkai, S. and Fiedler, J. and Alexander, K.M. and Wertheim, B.M. and Fisch, S. and Liao, R. and Diez, J. and González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

Spatial heterogeneity in molecular brightness.
Annibale, P. and Lohse, M.J.
Nature Methods 17 (3): 273-275. March 2020

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S. and Lim, E.L. and Horswell, S. and Haase, K. and Huebner, A. and Dietzen, M. and Mourikis, T.P. and Watkins, T.B.K. and Rowan, A. and Dewhurst, S.M. and Birkbak, N.J. and Wilson, G.A. and Van Loo, P. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature Genetics 52 (3): 283-293. March 2020

Antibody signatures in patients with histopathologically defined multiple sclerosis patterns.
Stork, L. and Ellenberger, D. and Ruprecht, K. and Reindl, M. and Beißbarth, T. and Friede, T. and Kümpfel, T. and Gerdes, L.A. and Gloth, M. and Liman, T. and Paul, F. and Brück, W. and Metz, I.
Acta neuropathologica 139 (3): 547-564. March 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K. and Fogo, M.S. and Pinto, B.G.G. and Alves, A.Y. and Suzuki, A.M. and Morales, A.G. and Ezquina, S. and Sosa, O.J. and Sutton, G.J. and Sunaga-Franze, D.Y. and Bueno, A.P. and Seabra, G. and Sardinha, L. and Costa, S.S. and Rosenberg, C. and Zachi, E.C. and Sertie, A.L. and Martins-de-Souza, D. and Reis, E.M. and Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 14 February 2020 (In Press)

"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T. and Kemna, J. and Leisegang, M.
EMBO Molecular Medicine 12 (2): e11801. 7 February 2020

Pan-cancer analysis of whole genomes.

Nature 578 (7793): 82-93. 6 February 2020

Genomic basis for RNA alterations in cancer.
Calabrese, C. and Davidson, N.R. and Demircioğlu, D. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, Q. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Huska, M.R. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
Nature 578 (7793): 129-136. 6 February 2020

Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M. and Fischer, C. and Urzi, A. and Vidal, R. and Kunz, S. and Ruffault, P.L. and Kabuss, L. and Hube, I. and Gazzerro, E. and Birchmeier, C. and Spuler, S. and Sauer, S. and Gouti, M.
Cell Stem Cell 26 (2): 172-186. 6 February 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y. and Chen, F. and Fonseca, N.A. and He, Y. and Fujita, M. and Nakagawa, H. and Zhang, Z. and Brazma, A. and Creighton, C.J.
Nature Communications 11 (1): 736. 5 February 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A. and Kny, M. and Pablo-Tortola, C. and Todiras, M. and Willenbrock, M. and Schmidt, S. and Schmoeckel, K. and Jorde, I. and Nowak, M. and Jarosch, E. and Sommer, T. and Bröker, B.M. and Felix, S.B. and Scheidereit, C. and Weber-Carstens, S. and Butter, C. and Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, P. and Muñoz-Fuentes, V. and Murray, S.A. and Dickinson, M.E. and Bucan, M. and Nutter, L.M.J. and Peterson, K.A. and Haselimashhadi, H. and Flenniken, A.M. and Morgan, H. and Westerberg, H. and Konopka, T. and Hsu, C.W. and Christiansen, A. and Lanza, D.G. and Beaudet, A.L. and Heaney, J.D. and Fuchs, H. and Gailus-Durner, V. and Sorg, T. and Prochazka, J. and Novosadova, V. and Lelliott, C.J. and Wardle-Jones, H. and Wells, S. and Teboul, L. and Cater, H. and Stewart, M. and Hough, T. and Wurst, W. and Sedlacek, R. and Adams, D.J. and Seavitt, J.R. and Tocchini-Valentini, G. and Mammano, F. and Braun, R.E. and McKerlie, C. and Herault, Y. and de Angelis, M.H. and Mallon, A.M. and Lloyd, K.C.K. and Brown, S.D.M. and Parkinson, H. and Meehan, T.F. and Smedley, D.
Nature Communications 11 (1): 655. 31 January 2020

Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D. and Mani, D.C. and Satpathy, S. and Fereshetian, S. and Gasser, J.A. and Svinkina, T. and Olive, M.E. and Ebert, B.L. and Mertins, P. and Carr, S.A.
Nature Communications 11 (1): 359. 17 January 2020

A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
Galupa, R. and Nora, E.P. and Worsley-Hunt, R. and Picard, C. and Gard, C. and van Bemmel, J.G. and Servant, N. and Zhan, Y. and El Marjou, F. and Johanneau, C. and Diabangouaya, P. and Le Saux, A. and Lameiras, S. and Pipoli da Fonseca, J. and Loos, F. and Gribnau, J. and Baulande, S. and Ohler, U. and Giorgetti, L. and Heard, E.
Molecular Cell 77 (2): 352-367. 16 January 2020

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J. and Mahnke, N.A. and Hofman, Z.L.M. and Maat, S.d. and Wu, J. and Bonnekoh, H. and Pengelly, R.J. and Ennis, S. and Holloway, J.W. and Kirchner, M. and Mertins, P. and Church, M.K. and Maurer, M. and Maas, C. and Krause, K.
Nature Communications 11 (1): 179. 10 January 2020

proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Mende, D.R. and Letunic, I. and Maistrenko, O.M. and Schmidt, T.S.B. and Milanese, A. and Paoli, L. and Hernández-Plaza, A. and Orakov, A.N. and Forslund, S.K. and Sunagawa, S. and Zeller, G. and Huerta-Cepas, J. and Coelho, L.P. and Bork, P.
Nucleic Acids Research 48 (D1): D621-D625. 8 January 2020

A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L. and Miskey, C. and Zuliani, C. and Querques, I. and Kapitonov, V. and Laukó, A. and Fehér, A. and Palazzo, A. and Diem, T. and Lustig, J. and Sebe, A. and Wang, Y. and Dinnyés, A. and Izsvák, Z. and Barabas, O. and Ivics, Z.
Nucleic Acids Research 48 (1): 316-331. 1 January 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020


Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A. and Escobar Fernandez, H. and Karaiskos, N. and Grunwald, S.A. and Metzler, E. and Kieshauer, J. and Sauer, S. and Pasemann, D. and Malfatti, E. and Mompoint, D. and Quijano-Roy, S. and Boltengagen, A. and Schneider, J. and Schülke, M. and Kunz, S. and Carlier, R. and Birchmeier, C. and Amthor, H. and Spuler, A. and Kocks, C. and Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

Gene expression cartography.
Nitzan, M. and Karaiskos, N. and Friedman, N. and Rajewsky, N.
Nature 576 (7785): 132-137. 5 December 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Wang, X. and Eichelbaum, K. and Sadewasser, A. and Husic, I. and Paki, K. and Budt, M. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

Long-term effects of Na(+)/Ca(2+) exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Primessnig, U. and Bracic, T. and Levijoki, J. and Otsomaa, L. and Pollesello, P. and Falcke, M. and Pieske, B. and Heinzel, F.R.
European Journal of Heart Failure 21 (12): 1543-1552. December 2019

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Csaba, Z. and Verdonk, F. and Montané, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Baud, O. and Rowitch, D. and Miron, V. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
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Gene expression changes and community turnover differentially shape the global ocean metatranscriptome.
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Nature Medicine 25 (10): 1549-1559. October 2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
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Nature Communications 10 (1): 4368. 25 September 2019

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
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Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
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Nature Communications 10 (1): 4205. 16 September 2019

Widespread translational control of fibrosis in the human heart by RNA-binding proteins.
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Antibiotics-induced monodominance of a novel gut bacterial order.
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Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
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BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
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Nature Methods 16 (9): 870-874. September 2019

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
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The role of sodium in modulating immune cell function.
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Nature Reviews Nephrology 15 (9): 546-558. September 2019

Maximizing binary interactome mapping with a minimal number of assays.
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Nature Communications 10 (1): 3907. 29 August 2019

Postnatal Tshz3 deletion drives altered corticostriatal function and autism spectrum disorder-like behavior.
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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
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Nature 572 (7769): 335-340. 15 August 2019

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
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Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
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How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.
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Autophagy 15 (8): 1475-1477. August 2019

Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial.
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Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
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Nature 571 (7765): 429-433. 18 July 2019

ATTRACT: arterial flow as attractor for endothelial cell migration.
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Circulation Research 125 (3): 262-264. July 2019

Genetics of intellectual disability in consanguineous families.
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Molecular Psychiatry 24 (7): 1027-1039. July 2019

Defining orphan conditions in the context of the European orphan regulation: challenges and evolution.
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Nature Reviews Drug Discovery 18 (7): 479-480. July 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
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Nature Cell Biology 21 (7): 812-823. July 2019

The translational landscape of the human heart.
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HOT or not: examining the basis of high-occupancy target regions.
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Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
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Blood 133 (24): 2597-2609. 13 June 2019

Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
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Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints.
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NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language.
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Microbiome 7 (1): 84. 3 June 2019

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
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Nature Genetics 51 (6): 1011-1023. June 2019

Rapid molecular evolution of pain insensitivity in multiple African rodents.
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Science 364 (6443): 852-859. 31 May 2019

Disentangling genetic and environmental effects on the proteotypes of individuals.
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Cell 177 (5): 1308-1318. 16 May 2019

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities.
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Cell 177 (4): 1035-1049. 2 May 2019

Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
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SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes.
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Does divergent binding pocket closure drive ligand bias for class A GPCRs?
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Detouring the roadblocks in gene expression.
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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
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PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.
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Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
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Mapping the lung.
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Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
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Microbial abundance, activity and population genomic profiling with mOTUs2.
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Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
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Nature Communications 10 (1): 990. 1 March 2019

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
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BCR-dependent lineage plasticity in mature B cells.
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Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
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Nature 566 (7742): 126-130. 7 February 2019

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
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Eleven loci with new reproducible genetic associations with allergic disease risk.
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Deciphering human ribonucleoprotein regulatory networks.
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Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
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E47 modulates hepatic glucocorticoid action.
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Nature Communications 10 (1): 306. 18 January 2019

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
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eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
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STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
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Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
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The dynamic nature of senescence in cancer.
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A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
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Nature Communications 9 (1): 5440. 21 December 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
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Blood 132 (25): 2670-2683. 20 December 2018

The IκB kinase complex is a regulator of mRNA stability.
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Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
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Nature Communications 9 (1): 5232. 12 December 2018

Good things come in threes.
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Science Immunology 3 (30): eaav5545. 7 December 2018

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.
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Nature Communications 9 (1): 5224. 6 December 2018

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
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The Senescence-Stemness Alliance - a cancer-hijacked regeneration principle.
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Trends in Cell Biology 28 (12): 1049-1061. December 2018

A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links.
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Nature Protocols 13 (12): 2781-2800. December 2018

Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.
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Nature Methods 15 (12): 1117-1125. December 2018

Discovering novel hydrolases from hot environments.
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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
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Nature Communications 9 (1): 5082. 30 November 2018

Ten things you should know about transposable elements.
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Genome Biology 19 (1): 199. 19 November 2018

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
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Nature Communications 9 (1): 4826. 16 November 2018

The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
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Molecular Cell 72 (4): 636-649. 15 November 2018

Potassium channel-based optogenetic silencing.
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Nature Communications 9 (1): 4611. 5 November 2018

omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data.
Drewe-Boss, P. and Wessels, H.H. and Ohler, U.
Genome Biology 19 : 183. 1 November 2018

Nervous system regionalization entails axial allocation before neural differentiation.
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Cell 175 (4): 1105-1118. 1 November 2018

Recovery of gut microbiota of healthy adults following antibiotic exposure.
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Nature Microbiology 3 : 1255-1265. November 2018

Determinants of promoter and enhancer transcription directionality in metazoans.
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Nature Communications 9 (1): 4472. 26 October 2018

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
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Immunity 49 (4): 615-626. 16 October 2018

Developmental and functional heterogeneity of monocytes.
Guilliams, M. and Mildner, A. and Yona, S.
Immunity 49 (4): 595-613. 16 October 2018

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E. and Loud, M.C. and Daou, I. and Marshall, K.L. and Schwaller, F. and Kühnemund, J. and Francisco, A.G. and Keenan, W.T. and Dubin, A.E. and Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K. and Milek, M. and Bogdanow, B. and Yasuda, T. and Kastelic, N. and Zauber, H. and Ishihama, Y. and Landthaler, M. and Selbach, M.
Molecular Cell 72 (1): 84-98. 4 October 2018

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
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Nature Genetics 50 (10): 1463-1473. October 2018

Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study.
Marenholz, I. and Grosche, S. and Rüschendorf, F. and Kalb, B. and Blumchen, K. and Schlags, R. and Harandi, N. and Price, M. and Hansen, G. and Seidenberg, J. and Yürek, S. and Homuth, G. and Schmidt, C.O. and Nöthen, M.M. and Hubner, N. and Niggemann, B. and Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 142 (4): 1368-1370. October 2018

Challenges and guidelines toward 4D nucleome data and model standards.
Marti-Renom, M.A. and Almouzni, G. and Bickmore, W.A. and Bystricky, K. and Cavalli, G. and Fraser, P. and Gasser, S.M. and Giorgetti, L. and Heard, E. and Nicodemi, M. and Nollmann, M. and Orozco, M. and Pombo, A. and Torres-Padilla, M.E.
Nature Genetics 50 (10): 1352-1358. October 2018

Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K. and Vogt, L. and Greber, B. and Diecke, S. and Boccaccini, A.R. and Scheibel, T. and Engel, F.B.
Advanced Functional Materials 28 (42): 1803951. October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn, J.D. and Miller, P.G. and Silver, A.J. and Sellar, R.S. and Bhatt, S. and Gibson, C. and McConkey, M. and Adams, D. and Mar, B. and Mertins, P. and Fereshetian, S. and Krug, K. and Zhu, H. and Letai, A. and Carr, S.A. and Doench, J. and Jaiswal, S. and Ebert, B.L.
Blood 132 (11): 1095-1105. 13 September 2018

mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A. and Buntru, A. and Schindler, F. and Hasenkopf, R. and Schulz, A. and Brusendorf, L. and Klockmeier, K. and Grelle, G. and McMahon, B. and Niederlechner, H. and Jansen, I. and Diez, L. and Edel, J. and Boeddrich, A. and Franklin, S.A. and Baldo, B. and Schnoegl, S. and Kunz, S. and Purfürst, B. and Gaertner, A. and Kampinga, H.H. and Morton, A.J. and Petersén, Å. and Kirstein, J. and Bates, G.P. and Wanker, E.E.
Molecular Cell 71 (5): 675-688. 6 September 2018

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T. and Braud, S. and Jüttner, R. and Voigt, B.C. and Paulick, K. and Sheean, M.E. and Klisch, C. and Gueneykaya, D. and Rathjen, F.G. and Geiger, J.R.P. and Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37 (17): e98858. 3 September 2018

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D. and Schön, C. and Loddenkemper, C. and Lohneis, P. and Kühl, A.A. and Sommermann, T. and Blankenstein, T. and Willimsky, G.
Blood 132 (9): 924-934. 30 August 2018

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S. and Gohlke, U. and Broeker, N.K. and Roske, Y. and Heinemann, U. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140 (33): 10447-10455. 22 August 2018

Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J. and Noel, J.K. and Low, H.H.
Nature Communications 9 (1): 3345. 21 August 2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
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Nature Communications 9 (1): 3259. 14 August 2018

Structure and function of the global topsoil microbiome.
Bahram, M. and Hildebrand, F. and Forslund, S.K. and Anderson, J.L. and Soudzilovskaia, N.A. and Bodegom, P.M. and Bengtsson-Palme, J. and Anslan, S. and Coelho, L.P. and Harend, H. and Huerta-Cepas, J. and Medema, M.H. and Maltz, M.R. and Mundra, S. and Olsson, P.A. and Pent, M. and Põlme, S. and Sunagawa, S. and Ryberg, M. and Tedersoo, L. and Bork, P.
Nature 560 (7717): 233-237. 9 August 2018

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome.
Maass, P.G. and Weise, A. and Rittscher, K. and Lichtenwald, J. and Barutcu, A.R. and Liehr, T. and Aydin, A. and Wefeld-Neuenfeld, Y. and Pölsler, L. and Tinschert, S. and Rinn, J.L. and Luft, F.C. and Bähring, S.
EMBO Journal 37 (15): e96257. 1 August 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
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Nature Genetics 50 (8): 1072-1080. August 2018

UnSASPing senescence: unmasking tumor suppression?
Schmitt, C.A.
Cancer Cell 34 (1): 6-8. 9 July 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B. and Hermes, R. and Colleoni, S. and Diecke, S. and Holtze, S. and Renfree, M.B. and Stejskal, J. and Hayashi, K. and Drukker, M. and Loi, P. and Göritz, F. and Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L. and Frainay, C. and Chazalviel, M. and Cabanettes, F. and Gloaguen, Y. and Camenen, E. and Merlet, B. and Heux, S. and Portais, J.C. and Poupin, N. and Vinson, F. and Jourdan, F.
Nucleic Acids Research 46 (W1): W495-W502. 2 July 2018

iPath3.0: interactive pathways explorer v3.
Darzi, Y. and Letunic, I. and Bork, P. and Yamada, T.
Nucleic Acids Research 46 (W1): W510-W513. 2 July 2018

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J. and Luong, T.T. and Tuffaha, R. and Musculus, K. and Auer, T. and Lian, X. and Daniel, C. and Zickler, D. and Boehme, B. and Sacherer, M. and Metzler, B. and Kuhl, D. and Gollasch, M. and Amann, K. and Müller, D.N. and Pieske, B. and Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128 (7): 3024-3040. 2 July 2018

Species-specific activity of antibacterial drug combinations.
Brochado, A.R. and Telzerow, A. and Bobonis, J. and Banzhaf, M. and Mateus, A. and Selkrig, J. and Huth, E. and Bassler, S. and Zamarreño Beas, J. and Zietek, M. and Ng, N. and Foerster, S. and Ezraty, B. and Py, B. and Barras, F. and Savitski, M.M. and Bork, P. and Göttig, S. and Typas, A.
Nature 559 (7713): 259-263. July 2018

CLC chloride channels and transporters: structure, function, physiology, and disease.
Jentsch, T.J. and Pusch, M.
Physiological Reviews 98 (3): 1493-1590. July 2018

Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Nature 559 (7713): 211-216. July 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Structural variation in the 3D genome.
Spielmann, M. and Lupiáñez, D.G. and Mundlos, S.
Nature Reviews Genetics 19 (7): 453-467. July 2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S. and Zhou, J. and Liu, J.B. and Wu, Z. and Xu, X. and Li, T. and Xu, D. and Schumacher, S.E. and Puschhof, J. and McFarland, J. and Zou, C. and Dulak, A. and Henderson, L. and Xu, P. and O'Day, E. and Rendak, R. and Liao, W.L. and Cecchi, F. and Hembrough, T. and Schwartz, S. and Szeto, C. and Rustgi, A.K. and Wong, K.K. and Diehl, J.A. and Jensen, K. and Graziano, F. and Ruzzo, A. and Fereshetian, S. and Mertins, P. and Carr, S.A. and Beroukhim, R. and Nakamura, K. and Oki, E. and Watanabe, M. and Baba, H. and Imamura, Y. and Catenacci, D. and Bass, A.J.
Nature Medicine 24 (7): 968-977. July 2018

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M. and Swinarski, M. and Meyer, A.M. and Müller, N.V. and Özcan, I. and Donat, S. and Burger, A. and Gilbert, S. and Mosimann, C. and Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
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Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

Peripheral serotonin synthesis as a new drug target.
Matthes, S. and Bader, M.
Trends in Pharmacological Sciences 39 (6): 560-572. June 2018

Pervasive protein thermal stability variation during the cell cycle.
Becher, I. and Andrés-Pons, A. and Romanov, N. and Stein, F. and Schramm, M. and Baudin, F. and Helm, D. and Kurzawa, N. and Mateus, A. and Mackmull, M.T. and Typas, A. and Müller, C.W. and Bork, P. and Beck, M. and Savitski, M.M.
Cell 173 (6): 1495-1507. 31 May 2018

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M. and Solana, J. and Wolf, F.A. and Ayoub, S. and Misios, A. and Glažar, P. and Obermayer, B. and Theis, F.J. and Kocks, C. and Rajewsky, N.
Science 360 (6391): eaaq1723. 25 May 2018

Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y. and Sabag, O. and Skversky, Y. and Spiro, A. and Steinberg, B. and Bernstein, D. and Wang, A. and Kieckhaefer, J. and Li, C. and Pikarsky, E. and Levin-Klein, R. and Goren, A. and Rajewsky, K. and Kaestner, K.H. and Cedar, H.
Nature Communications 9 (1): 2040. 23 May 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A. and Prummel, K.D. and Merks, A.M. and Mickoleit, M. and Brombacher, E.C. and Huisken, J. and Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B. and Nagy, G. and Horvath, A. and Czimmerer, Z. and Cuaranta-Monroy, I. and Poliska, S. and Hays, T.T. and Sauer, S. and Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46 (9): 4425-4439. 18 May 2018

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T. and Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9 (1): 1974. 17 May 2018

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M. and Gonzalez, E. and Teixeira da Costa, A.R. and Wask, L. and Gravenstein, I. and Pardo, M. and Pietzke, M. and Gurumurthy, R.K. and Angermann, J. and Laudeley, R. and Glage, S. and Meyer, M. and Chumduri, C. and Kempa, S. and Dinkel, K. and Unger, A. and Klebl, B. and Klos, A. and Meyer, T.F.
Cell Host & Microbe 23 (5): 661-671. 9 May 2018

Polymer physics predicts the effects of structural variants on chromatin architecture.
Bianco, S. and Lupiáñez, D.G. and Chiariello, A.M. and Annunziatella, C. and Kraft, K. and Schöpflin, R. and Wittler, L. and Andrey, G. and Vingron, M. and Pombo, A. and Mundlos, S. and Nicodemi, M.
Nature Genetics 50 (5): 662-667. May 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L. and Alvarez-Martinez, M. and Luisier, R. and Cox, L.S. and Sodenkamp, J. and Hosking, C. and Pérez-Mazliah, D. and Whicher, C. and Kannan, Y. and Potempa, K. and Wu, X. and Bhaw, L. and Wende, H. and Sieweke, M.H. and Elgar, G. and Wilson, M. and Briscoe, J. and Metzis, V. and Langhorne, J. and Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars.
Spanjaard, B. and Hu, B. and Mitic, N. and Olivares-Chauvet, P. and Janjuha, S. and Ninov, N. and Junker, J.P.
Nature Biotechnology 36 (5): 469-473. May 2018

Similarity of the dog and human gut microbiomes in gene content and response to diet.
Coelho, L.P. and Kultima, J.R. and Costea, P.I. and Fournier, C. and Pan, Y. and Czarnecki-Maulden, G. and Hayward, M.R. and Forslund, S.K. and Schmidt, T.S.B. and Descombes, P. and Jackson, J.R. and Li, Q. and Bork, P.
Microbiome 6 (1): 72. 19 April 2018

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.
Turajlic, S. and Xu, H. and Litchfield, K. and Rowan, A. and Horswell, S. and Chambers, T. and O'Brien, T. and Lopez, J.I. and Watkins, T.B.K. and Nicol, D. and Stares, M. and Challacombe, B. and Hazell, S. and Chandra, A. and Mitchell, T.J. and Au, L. and Eichler-Jonsson, C. and Jabbar, F. and Soultati, A. and Chowdhury, S. and Rudman, S. and Lynch, J. and Fernando, A. and Stamp, G. and Nye, E. and Stewart, A. and Xing, W. and Smith, J.C. and Escudero, M. and Huffman, A. and Matthews, N. and Elgar, G. and Phillimore, B. and Costa, M. and Begum, S. and Ward, S. and Salm, M. and Boeing, S. and Fisher, R. and Spain, L. and Navas, C. and Grönroos, E. and Hobor, S. and Sharma, S. and Aurangzeb, I. and Lall, S. and Polson, A. and Varia, M. and Horsfield, C. and Fotiadis, N. and Pickering, L. and Schwarz, R.F. and Silva, B. and Herrero, J. and Luscombe, N.M. and Jamal-Hanjani, M. and Rosenthal, R. and Birkbak, N.J. and Wilson, G.A. and Pipek, O. and Ribli, D. and Krzystanek, M. and Csabai, I. and Szallasi, Z. and Gore, M. and McGranahan, N. and Van Loo, P. and Campbell, P. and Larkin, J. and Swanton, C.
Cell 173 (3): 595-610. 19 April 2018

Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo.
Jouhanneau, J.S. and Kremkow, J. and Poulet, J.F.A.
Nature Communications 9 (1): 1540. 18 April 2018

Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G. and Kim, Y. and de Almeida, P.E. and Termglinchan, V. and Diecke, S. and Shao, N.Y. and Wei, T.T. and Yi, H. and Dey, De. and Nelakanti, R. and Brouwer, T.P. and Paik, D.T. and Sagiv-Barfi, I. and Han, A. and Quax, P.H.A. and Hamming, J.F. and Levy, R. and Davis, M.M. and Wu, J.C.
Cell Stem Cell 22 (4): 501-513. 5 April 2018

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y. and Eslami, A. and van Ginkel, C.D. and Akhabir, L. and Wan, M. and Yin, D. and Ellis, G. and Ben-Shoshan, M. and Marenholz, I. and Martino, D. and Ferreira, M.A. and Allen, K. and Mazer, B. and de Groot, H. and de Jong, N.W. and Gerth van Wijk, R. and Dubois, A.E.J. and Grosche, S. and Ashley, S. and Rüschendorf, F. and Kalb, B. and Beyer, K. and Nöthen, M.M. and Lee, Y.A. and Chin, R. and Cheuk, S. and Hoffman, J. and Jorgensen, E. and Witte, J.S. and Melles, R.B. and Hong, X. and Wang, X. and Hui, J. and Musk, A.W.B. and Hunter, M. and James, A.L. and Koppelman, G.H. and Sandford, A.J. and Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141 (4): 1513-1516. April 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.
Tramontano, M. and Andrejev, S. and Pruteanu, M. and Klünemann, M. and Kuhn, M. and Galardini, M. and Jouhten, P. and Zelezniak, A. and Zeller, G. and Bork, P. and Typas, A. and Patil, K.R.
Nature Microbiology 3 (3): 514-522. April 2018

Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier, L. and Pruteanu, M. and Kuhn, M. and Zeller, G. and Telzerow, A. and Anderson, E.E. and Brochado, A.R. and Fernandez, K.C. and Dose, H. and Mori, H. and Patil, K.R. and Bork, P. and Typas, A.
Nature 555 (7698): 623-628. 29 March 2018

SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K. and Kranz, A. and Fohgrub, J. and Jolly, A. and Bledau, A.S. and Di Virgilio, M. and Lesche, M. and Dahl, A. and Höfer, T. and Stewart, A.F. and Waskow, C.
Blood 131 (12): 1311-1324. 22 March 2018

Transposase-DNA complex structures reveal mechanisms for conjugative transposition of antibiotic resistance.
Rubio-Cosials, A. and Schulz, E.C. and Lambertsen, L. and Smyshlyaev, G. and Rojas-Cordova, C. and Forslund, K. and Karaca, E. and Bebel, A. and Bork, P. and Barabas, O.
Cell 173 (1): 208-220. 22 March 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Voltage gating of mechanosensitive PIEZO channels.
Moroni, M. and Servin-Vences, M.R. and Fleischer, R. and Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9 (1): 1096. 15 March 2018

High-throughput identification of RNA nuclear enrichment sequences.
Shukla, C.J. and McCorkindale, A.L. and Gerhardinger, C. and Korthauer, K.D. and Cabili, M.N. and Shechner, D.M. and Irizarry, R.A. and Maass, P. and Rinn, J.L.
EMBO Journal 37 (6): e98452. 15 March 2018

Faecal microbiota composition associates with abdominal pain in the general population.
Hadizadeh, F. and Bonfiglio, F. and Belheouane, M. and Vallier, M. and Sauer, S. and Bang, C. and Bujanda, L. and Andreasson, A. and Agreus, L. and Engstrand, L. and Talley, N.J. and Rafter, J. and Baines, J.F. and Walter, S. and Franke, A. and D'Amato, M.
Gut 67 (4): 778-779. 8 March 2018

The human gut microbiome: from association to modulation.
Schmidt, T.S.B. and Raes, J. and Bork, P.
Cell 172 (6): 1198-1215. 8 March 2018

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Fernandes-Rosa, F.L. and Daniil, G. and Orozco, I.J. and Göppner, C. and El Zein, R. and Jain, V. and Boulkroun, S. and Jeunemaitre, X. and Amar, L. and Lefebvre, H. and Schwarzmayr, T. and Strom, T.M. and Jentsch, T.J. and Zennaro, M.C.
Nature Genetics 50 (3): 355-361. March 2018

Redundant regulation.
Lacadie, S.A. and Ohler, U.
Nature Ecology & Evolution 2 (3): 418-419. March 2018

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Scholl, U.I. and Stölting, G. and Schewe, J. and Thiel, A. and Tan, H. and Nelson-Williams, C. and Vichot, A.A. and Jin, S.C. and Loring, E. and Untiet, V. and Yoo, T. and Choi, J. and Xu, S. and Wu, A. and Kirchner, M. and Mertins, P. and Rump, L.C. and Onder, A.M. and Gamble, C. and McKenney, D. and Lash, R.W. and Jones, D.P. and Chune, G. and Gagliardi, P. and Choi, M. and Gordon, R. and Stowasser, M. and Fahlke, C. and Lifton, R.P.
Nature Genetics 50 (3): 349-354. March 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Picky: a simple online PRM and SRM method designer for targeted proteomics.
Zauber, H. and Kirchner, M. and Selbach, M.
Nature Methods 15 (3): 156-157. 28 February 2018

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability.
Dawes, J.M. and Weir, G.A. and Middleton, S.J. and Patel, R. and Chisholm, K.I. and Pettingill, P. and Peck, L.J. and Sheridan, J. and Shakir, A. and Jacobson, L. and Gutierrez-Mecinas, M. and Galino, J. and Walcher, J. and Kühnemund, J. and Kuehn, H. and Sanna, M.D. and Lang, B. and Clark, A.J. and Themistocleous, A.C. and Iwagaki, N. and West, S.J. and Werynska, K. and Carroll, L. and Trendafilova, T. and Menassa, D.A. and Giannoccaro, M.P. and Coutinho, E. and Cervellini, I. and Tewari, D. and Buckley, C. and Leite, M.I. and Wildner, H. and Zeilhofer, H.U. and Peles, E. and Todd, A.J. and McMahon, S.B. and Dickenson, A.H. and Lewin, G.R. and Vincent, A. and Bennett, D.L.
Neuron 97 (4): 806-822. 21 February 2018

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.
Szulzewsky, F. and Schwendinger, N. and Güneykaya, D. and Cimino, P.J. and Hambardzumyan, D. and Synowitz, M. and Holland, E.C. and Kettenmann, H.
Neuro-Oncology 20 (3): 355-366. 19 February 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y. and Schleich, K. and Yue, B. and Ji, S. and Lohneis, P. and Kemper, K. and Silvis, M.S. and Qutob, N. and van Rooijen, E. and Werner-Klein, M. and Li, L. and Dhawan, D. and Meierjohann, S. and Reimann, M. and Elkahloun, A. and Treitschke, S. and Dörken, B. and Speck, C. and Mallette, F.A. and Zon, L.I. and Holmen, S.L. and Peeper, D.S. and Samuels, Y. and Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Precisely timed nicotinic activation drives SST inhibition in neocortical circuits.
Urban-Ciecko, J. and Jouhanneau, J.S. and Myal, S.E. and Poulet, J.F.A. and Barth, A.L.
Neuron 97 (3): 611-625. 7 February 2018

The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
Althof, N. and Goetzke, C.C. and Kespohl, M. and Voss, K. and Heuser, A. and Pinkert, S. and Kaya, Z. and Klingel, K. and Beling, A.
EMBO Molecular Medicine 10 (2): 200-218. 1 February 2018

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer, E.E. and Stuhlmann, T. and Weinert, S. and Haan, E. and Van Esch, H. and Holvoet, M. and Boyle, J. and Leffler, M. and Raynaud, M. and Moraine, C. and van Bokhoven, H. and Kleefstra, T. and Kahrizi, K. and Najmabadi, H. and Ropers, H.H. and Delgado, M.R. and Sirsi, D. and Golla, S. and Sommer, A. and Pietryga, M.P. and Chung, W.K. and Wynn, J. and Rohena, L. and Bernardo, E. and Hamlin, D. and Faux, B.M. and Grange, D.K. and Manwaring, L. and Tolmie, J. and Joss, S. and Cobben, J.M. and Duijkers, F.A.M. and Goehringer, J.M. and Challman, T.D. and Hennig, F. and Fischer, U. and Grimme, A. and Suckow, V. and Musante, L. and Nicholl, J. and Shaw, M. and Lodh, S.P. and Niu, Z. and Rosenfeld, J.A. and Stankiewicz, P. and Jentsch, T.J. and Gecz, J. and Field, M. and Kalscheuer, V.M.
Molecular Psychiatry 23 (2): 222-230. February 2018

A global ocean atlas of eukaryotic genes.
Carradec, Q. and Pelletier, E. and Da Silva, C. and Alberti, A. and Seeleuthner, Y. and Blanc-Mathieu, R. and Lima-Mendez, G. and Rocha, F. and Tirichine, L. and Labadie, K. and Kirilovsky, A. and Bertrand, A. and Engelen, S. and Madoui, M.A. and Méheust, R. and Poulain, J. and Romac, S. and Richter, D.J. and Yoshikawa, G. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Jaillon, O. and Aury, J.M. and Karsenti, E. and Sullivan, M.B. and Sunagawa, S. and Bork, P. and Not, F. and Hingamp, P. and Raes, J. and Guidi, L. and Ogata, H. and De Vargas, C. and Iudicone, D. and Bowler, C. and Wincker, P.
Nature Communications 9 (1): 373. 25 January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A. and Buntru, A. and Arnsburg, K. and Ast, A. and Iburg, M. and Juenemann, K. and Pigazzini, M.L. and Mlody, B. and Puchkov, D. and Priller, J. and Wanker, E.E. and Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z. and Daniel, B. and Horvath, A. and Rückerl, D. and Nagy, G. and Kiss, M. and Peloquin, M. and Budai, M.M. and Cuaranta-Monroy, I. and Simandi, Z. and Steiner, L. and Nagy, B. and Poliska, S. and Banko, C. and Bacso, Z. and Schulman, I.G. and Sauer, S. and Deleuze, J.F. and Allen, J.E. and Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

MVP: a microbe-phage interaction database.
Gao, N.L. and Zhang, C. and Zhang, Z. and Hu, S. and Lercher, M.J. and Zhao, X.M. and Bork, P. and Liu, Z. and Chen, W.H.
Nucleic Acids Research 46 (D1): D700-D707. 4 January 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M. and Klinger, B. and Klünemann, M. and Sieber, A. and Uhlitz, F. and Sauer, S. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

Enterotypes in the landscape of gut microbial community composition.
Costea, P.I. and Hildebrand, F. and Manimozhiyan, A. and Baeckhed, F. and Blaser, M.J. and Bushman, F.D. and de Vos, W.M. and Ehrlich, S.D. and Fraser, C.M. and Hattori, M. and Huttenhower, C. and Jeffery, I.B. and Knights, D. and Lewis, J.D. and Ley, R.E. and Ochman, H. and O'Toole, P.W. and Quince, C. and Relman, D.A. and Shanahan, F. and Sunagawa, S. and Wang, J. and Weinstock, G.M. and Wu, G.D. and Zeller, G. and Zhao, L. and Raes, J. and Knight, R. and Bork, P.
Nature Microbiology 3 (1): 8-16. January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F. and Margaritte-Jeannin, P. and Barnes, K.C. and Cookson, W.O.C. and Altmueller, J. and Ang, W. and Barr, R.G. and Beaty, T.H. and Becker, A.B. and Beilby, J. and Bisgaard, H. and Bjornsdottir, U.S. and Bleecker, E. and Bonnelykke, K. and Boomsma, D.I. and Bouzigon, E. and Brightling, C.E. and Brossard, M. and Brusselle, G.G. and Burchard, E. and Burkart, K.M. and Bush, A. and Chan-Yeung, M. and Chung, K.F. and Couto Alves, A. and Curtin, J.A. and Custovic, A. and Daley, D. and de Jongste, J.C. and Del-Rio-Navarro, B.E. and Donohue, K.M. and Duijts, L. and Eng, C. and Eriksson, J.G. and Farrall, M. and Fedorova, Y. and Feenstra, B. and Ferreira, M.A. and Freidin, M.B. and Gajdos, Z. and Gauderman, J. and Gehring, U. and Geller, F. and Genuneit, J. and Gharib, S.A and Gilliland, F. and Granell, R. and Graves, P.E. and Gudbjartsson, D.F. and Haahtela, T. and Heckbert, S.R. and Heederik, D. and Heinrich, J. and Helioevaara, M. and Henderson, J. and Himes, B.E. and Hirose, H. and Hirschhorn, J.N. and Hofman, A. and Holt, P. and Hottenga, J. and Hudson, T.J. and Hui, J. and Imboden, M. and Ivanov, V. and Jaddoe, V.W.V. and James, A. and Janson, C. and Jarvelin, M.R. and Jarvis, D. and Jones, G. and Jonsdottir, I. and Jousilahti, P. and Kabesch, M. and Kähönen, M. and Kantor, D.B. and Karunas, A.S. and Khusnutdinova, E. and Koppelman, G.H. and Kozyrskyj, A.L. and Kreiner, E. and Kubo, M. and Kumar, R. and Kumar, A. and Kuokkanen, M. and Lahousse, L. and Laitinen, T. and Laprise, C. and Lathrop, M. and Lau, S. and Lee, Y.A. and Lehtimaeki, T. and Letort, S. and Levin, A.M. and Li, G. and Liang, L. and Loehr, L.R. and London, S.J. and Loth, D.W. and Manichaikul, A. and Marenholz, I. and Martinez, F.J. and Matheson, M.C. and Mathias, R.A. and Matsumoto, K. and Mbarek, H. and McArdle, W.L. and Melbye, M. and Melen, E. and Meyers, D. and Michel, S. and Mohamdi, H. and Musk, A.W. and Myers, R.A. and Nieuwenhuis, M.A.E. and Noguchi, E. and O'Connor, G.T. and Ogorodova, L.M. and Palmer, C.D. and Palotie, A. and Park, J.E. and Pennell, C.E. and Pershagen, G. and Polonikov, A. and Postma, D.S. and Probst-Hensch, N. and Puzyrev, V.P. and Raby, B.A. and Raitakari, O.T. and Ramasamy, A. and Rich, S.S. and Robertson, C.F. and Romieu, I. and Salam, M.T. and Salomaa, V. and Schluenssen, V. and Scott, R. and Selivanova, P.A. and Sigsgaard, T. and Simpson, A. and Siroux, V. and Smith, L.J. and Solodilova, M. and Standl, M. and Stefansson, K. and Strachan, D.P. and Stricker, B.H. and Takahashi, A. and Thompson, P.J. and Thorleifsson, G. and Thorsteinsdottir, U. and Tiesler, C.M.T. and Torgerson, D.G. and Tsunoda, T. and Uitterlinden, A.G. and van der Valk, R.J.P. and Vaysse, A. and Vedantam, S. and von Berg, A. and von Mutius, E. and Vonk, J.M. and Waage, J. and Wareham, N.J. and Weiss, S.T. and White, W.B. and Wickman, M. and Widén, E. and Willemsen, G. and Williams, L.K. and Wouters, I.M. and Yang, J.J. and Zhao, J.H. and Moffatt, M.F. and Ober, C. and Nicolae, D.L.
Nature Genetics 50 (1): 42-53. January 2018

The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7).
Santos, R.A.S. and Sampaio, W.O. and Alzamora, A.C. and Motta-Santos, D. and Alenina, N. and Bader, M. and Campagnole-Santos, M.J.
Physiological Reviews 98 (1): 505-553. January 2018

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Lancet 392 (10159): 1923-1994. 2018


The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.
Verduci, L. and Ferraiuolo, M. and Sacconi, A. and Ganci, F. and Vitale, J. and Colombo, T. and Paci, P. and Strano, S. and Macino, G. and Rajewsky, N. and Blandino, G.
Genome Biology 18 (1): 237. 20 December 2017

Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M. and Gallion, J. and Picard, L.P. and Wilkins, A.D. and Le Gouill, C. and Audet, M. and Stallaert, W. and Lohse, M.J. and Kimmel, M. and Lichtarge, O. and Bouvier, M.
Nature Communications 8 (1): 2169. 18 December 2017

IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S. and Viswanathan, S. and Widjaja, A.A. and Lim, W.W. and Moreno-Moral, A. and DeLaughter, D.M. and Ng, B. and Patone, G. and Chow, K. and Khin, E. and Tan, J. and Chothani, S.P. and Ye, L. and Rackham, O.J. and Ko, N.S. and Sahib, N.E. and Pua, C.J. and Zhen, N.T. and Xie, C. and Wang, M. and Maatz, H. and Lim, S. and Saar, K. and Blachut, S. and Petretto, E. and Schmidt, S. and Putoczki, T. and Guimarães-Camboa, N. and Wakimoto, H. and van Heesch, S. and Sigmundsson, K. and Lim, S.L. and Soon, J.L. and Chao, V.T. and Chua, Y.L. and Tan, T.E. and Evans, S.M. and Loh, Y.J. and Jamal, M.H. and Ong, K.K. and Chua, K.C. and Ong, B.H. and Chakaramakkil, M.J. and Seidman, J.G. and Seidman, C.E. and Hubner, N. and Sin, K.Y. and Cook, S.A.
Nature 552 (7683): 110-115. 7 December 2017

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F. and Haas, J. and Zhu, F. and Geier, C. and Kayvanpour, E. and Liss, M. and Lai, A. and Frese, K. and Pribe-Wolferts, R. and Amr, A. and Li, D.T. and Samani, O.S. and Carstensen, A. and Bordalo, D.M. and Müller, M. and Fischer, C. and Shao, J. and Wang, J. and Nie, M. and Yuan, L. and Haßfeld, S. and Schwartz, C. and Zhou, M. and Zhou, Z. and Shu, Y. and Wang, M. and Huang, K. and Zeng, Q. and Cheng, L. and Fehlmann, T. and Ehlermann, P. and Keller, A. and Dieterich, C. and Streckfuß-Bömeke, K. and Liao, Y. and Gotthardt, M. and Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y. and Zhao, Y. and Jiang, L.L. and Li, X. and Liu, Y. and Sun, Y. and Piña-Crespo, J.C. and Zhu, B. and Masliah, E. and Willnow, T.E. and Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214 (12): 3669-3685. 4 December 2017

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A. and Dejanovic, B. and Hetsch, F. and Semtner, M. and Fusca, D. and Arjune, S. and Santamaria-Araujo, J.A. and Winkelmann, A. and Ayton, S. and Bush, A.I. and Kloppenburg, P. and Meier, J.C. and Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127 (12): 4365-4378. 1 December 2017

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Mathivet, T. and Bouleti, C. and Van Woensel, M. and Stanchi, F. and Verschuere, T. and Phng, L.K. and Dejaegher, J. and Balcer, M. and Matsumoto, K. and Georgieva, P.B. and Belmans, J. and Sciot, R. and Stockmann, C. and Mazzone, M. and De Vleeschouwer, S. and Gerhardt, H.
EMBO Molecular Medicine 9 (12): 1629-1645. 1 December 2017

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.
Eichenauer, D.A. and Plütschow, A. and Kreissl, S. and Sökler, M. and Hellmuth, J.C. and Meissner, J. and Mathas, S. and Topp, M.S. and Behringer, K. and Klapper, W. and Kuhnert, G. and Dietlein, M. and Kobe, C. and Fuchs, M. and Diehl, V. and Engert, A. and Borchmann, P.
Lancet Oncology 18 (12): 1680-1687. December 2017

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
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Nature Genetics 49 (12): 1752-1757. December 2017

Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49 : 71-76. December 2017

Methods for lineage tracing on the organism-wide level.
Spanjaard, B. and Junker, J.P.
Current Opinion in Cell Biology 49 : 16-21. December 2017

Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N. and Matus, M.G. and Kearney, S.M. and Olesen, S.W. and Forslund, K. and Bartolomaeus, H. and Haase, S. and Mähler, A. and Balogh, A. and Markó, L. and Vvedenskaya, O. and Kleiner, F.H. and Tsvetkov, D. and Klug, L. and Costea, P.I. and Sunagawa, S. and Maier, L. and Rakova, N. and Schatz, V. and Neubert, P. and Frätzer, C. and Krannich, A. and Gollasch, M. and Grohme, D.A. and Côrte-Real, B.F. and Gerlach, R.G. and Basic, M. and Typas, A. and Wu, C. and Titze, J.M. and Jantsch, J. and Boschmann, M. and Dechend, R. and Kleinewietfeld, M. and Kempa, S. and Bork, P. and Linker, R.A. and Alm, E.J. and Müller, D.N.
Nature 551 (7682): 585-589. 30 November 2017

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Sassi, Y. and Avramopoulos, P. and Ramanujam, D. and Grüter, L. and Werfel, S. and Giosele, S. and Brunner, A.D. and Esfandyari, D. and Papadopoulou, A.S and De Strooper, B. and Hübner, N. and Kumarswamy, R. and Thum, T. and Yin, X. and Mayr, M. and Laggerbauer, B. and Engelhardt, S.
Nature Communications 8 (1): 1614. 20 November 2017

Trained macrophages support hygiene hypothesis.
de Laval, B. and Sieweke, M.H.
Nature Immunology 18 (12): 1279-1280. 16 November 2017

Building bridges through science.
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Neuron 96 (4): 730-735. 15 November 2017

Transient cardiomyocyte fusion regulates cardiac development in zebrafish.
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Nature Communications 8 (1): 1525. 15 November 2017

Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
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Circulation 136 (19): 1824-1839. 7 November 2017

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
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Journal of Experimental Medicine 214 (11): 3417-3433. 6 November 2017

ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
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Nucleic Acids Research 45 (19): 11004-11018. 2 November 2017

Optogenetic tools for subcellular applications in neuroscience.
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Neuron 96 (3): 572-603. 1 November 2017

Towards standards for human fecal sample processing in metagenomic studies.
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Nature Biotechnology 35 (11): 1069-1076. November 2017

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
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Leukemia 31 (11): 2398-2406. November 2017

Gene therapy with the Sleeping Beauty transposon system.
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Trends in Genetics 33 (11): 852-870. November 2017

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
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BMJ 359 : j4761. 31 October 2017

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E. and Menegatti, J. and Franke, V. and Kocks, C. and Boltengagen, A. and Hennig, T. and Theil, K. and Rutkowski, A. and Ferrai, C. and Baer, L. and Kermas, L. and Friedel, C. and Rajewsky, N. and Akalin, A. and Dölken, L. and Grässer, F. and Landthaler, M.
Genome Biology 18 (1): 209. 31 October 2017

McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
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Genome Biology 18 (1): 199. 26 October 2017

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T. and Jobin, M.L. and Burnecki, K. and Weron, A. and Lohse, M.J. and Calebiro, D.
Nature 550 (7677): 543-547. 26 October 2017

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I. and Grosche, S. and Kalb, B. and Rüschendorf, F. and Blümchen, K. and Schlags, R. and Harandi, N. and Price, M. and Hansen, G. and Seidenberg, J. and Röblitz, H. and Yürek, S. and Tschirner, S. and Hong, X. and Wang, X. and Homuth, G. and Schmidt, C.O. and Nöthen, M.M. and Hübner, N. and Niggemann, B. and Beyer, K. and Lee, Y.A.
Nature Communications 8 (1): 1056. 20 October 2017

Casein kinase 1-epsilonor1-delta required for Wnt-mediated intestinal stem cell maintenance.
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EMBO Journal 36 (20): 3046-3061. 16 October 2017

T cell receptors for clinical therapy: in vitro assessment of toxicity risk.
Kunert, A. and Obenaus, M. and Lamers, C.H.J. and Blankenstein, T. and Debets, R.
Clinical Cancer Research 23 (20): 6012-6020. 15 October 2017

The Drosophila embryo at single-cell transcriptome resolution.
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Science 358 (6360): 194-199. 13 October 2017

Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.
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Circulation 136 (15): 1396-1409. 10 October 2017

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
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Nature 550 (7674): 114-118. 5 October 2017

Developmental origin and maintenance of distinct testicular macrophage populations.
Mossadegh-Keller, N. and Gentek, R. and Gimenez, G. and Bigot, S. and Mailfert, S. and Sieweke, M.H.
Journal of Experimental Medicine 214 (10): 2829-2841. 2 October 2017

Beyond read-counts: Ribo-seq data analysis to understand the functions of the transcriptome.
Calviello, L. and Ohler, U.
Trends in Genetics 33 (10): 728-744. October 2017

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations.
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Nature Methods 14 (10): 935-936. 29 September 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
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Science 357 (6357): eaam8526. 22 September 2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A. and van den Bruck, D. and Ciolli Mattioli, C. and Franke, V. and Imami, K. and McShane, E. and Moreno-Estelles, M. and Calviello, L. and Filipchyk, A. and Peguero-Sanchez, E. and Müller, T. and Woehler, A. and Birchmeier, C. and Merino, E. and Rajewsky, N. and Ohler, U. and Mazzoni, E.O. and Selbach, M. and Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

The 4D nucleome project.
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Nature 549 (7671): 219-226. 14 September 2017

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
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Genome Biology 18 (1): 170. 14 September 2017

A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
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Cancer Cell 32 (3): 342-359. 11 September 2017

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S. and Witte, N. and Weber, P. and Goehring, I. and Tolkachov, A. and von Loeffelholz, C. and Döcke, S. and Bauer, M. and Stockmann, M. and Pfeiffer, A.F.H. and Birkenfeld, A.L. and Pietzke, M. and Kempa, S. and Muenzner, M. and Schupp, M.
Nature Communications 8 (1): 384. 30 August 2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F. and Maurizio, J. and Vargas Aguilar, S. and Busch, C.J. and Favret, J. and Kowenz-Leutz, E. and Cathou, W. and Gentek, R. and Perrin, P. and Leutz, A. and Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C. and Werner, A. and John, D. and Boeckel, J.-N. and Melissari, M.-T. and Grote, P. and Glaser, S.F. and Demolli, S. and Uchida, S. and Michalik, K.M. and Meder, B. and Katus, H.A. and Haas, J. and Chen, W. and Pullamsetti, S.S. and Seeger, W. and Zeiher, A.M. and Dimmeler, S. and Zehendner, C.M.
Circulation Research 121 (4): 368-375. 4 August 2017

Fast genome-wide functional annotation through orthology assignment by eggNOG-mapper.
Huerta-Cepas, J. and Forslund, K. and Coelho, L.P. and Szklarczyk, D. and Jensen, L.J. and von Mering, C. and Bork, P.
Molecular Biology and Evolution 34 (8): 2115-2122. 1 August 2017

Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies.
Rohr, U.P. and Herrmann, P. and Ilm, K. and Zhang, H. and Lohmann, S. and Reiser, A. and Muranyi, A. and Smith, J. and Burock, S. and Osterland, M. and Leith, K. and Singh, S. and Brunhoeber, P. and Bowermaster, R. and Tie, J. and Christie, M. and Wong, H.L. and Waring, P. and Shanmugam, K. and Gibbs, P. and Stein, U.
Annals of Oncology 28 (8): 1869-1875. 1 August 2017

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
Herce, H.D. and Schumacher, D. and Schneider, A.F.L. and Ludwig, A.K. and Mann, F.A. and Fillies, M. and Kasper, M.-A. and Reinke, S. and Krause, E. and Leonhardt, H. and Cardoso, M.C. and Hackenberger, C.P.R.
Nature Chemistry 9 (8): 762-771. August 2017

DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M. and Imami, K. and Mukherjee, N. and De Bortoli, F. and Zinnall, U. and Hazapis, O. and Trahan, C. and Oeffinger, M. and Heyd, F. and Ohler, U. and Selbach, M. and Landthaler, M.
Genome Research 27 (8): 1344-1359. August 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T. and Yan, X. and Kononenko, N.L. and Ku, M.C. and Song, K. and Ferrarese, L. and Tarallo, V. and Puchkov, D. and Kochlamazashvili, G. and Brachs, S. and Varela, L. and Szigeti-Buck, K. and Yi, C.X. and Schriever, S.C. and Tattikota, S.G. and Carlo, A.S. and Moroni, M. and Siemens, J. and Heuser, A. and van der Weyden, L. and Birkenfeld, A.L. and Niendorf, T. and Poulet, J.F.A. and Horvath, T.L. and Tschöp, M.H. and Heinig, M. and Trajkovski, M. and Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V. and Birdsey, G.M. and Peghaire, C. and Pitulescu, M.E. and Dufton, N.P. and Yang, Y. and Weinberg, I. and Osuna Almagro, L. and Payne, L. and Mason, J.C. and Gerhardt, H. and Adams, R.H. and Randi, A.M.
Nature Communications 8 : 16002. 11 July 2017

Cell cycle: continuous chromatin changes.
Beagrie, R.A. and Pombo, A.
Nature 547 (7661): 34-35. 6 July 2017

The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure, F.R. and Royla, N. and Herold, S. and Kalb, J. and Walz, S. and Ade, C.P. and Mastrobuoni, G. and Vanselow, J.T. and Schlosser, A. and Wolf, E. and Kempa, S. and Eilers, M.
EMBO Journal 36 (13): 1854-1868. 3 July 2017

Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
Eulenberg-Gustavus, C. and Bähring, S. and Maass, P. and Luft, F.C. and Kettritz, R.
Journal of Experimental Medicine 214 (7): 2089-2101. 3 July 2017

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
Grüning, B.A. and Fallmann, J. and Yusuf, D. and Will, S. and Erxleben, A. and Eggenhofer, F. and Houwaart, T. and Batut, B. and Videm, P. and Bagnacani, A. and Wolfien, M. and Lott, S.C. and Hoogstrate, Y. and Hess, W.R. and Wolkenhauer, O. and Hoffmann, S. and Akalin, A. and Ohler, U. and Stadler, P.F. and Backofen, R.
Nucleic Acids Research 45 (W1): W560-W566. 3 July 2017

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J. and Novitzky-Basso, I. and Thiriot, A. and Casanova-Acebes, M. and Bianchini, M. and Etheridge, S.L. and Hub, E. and Nitz, K. and Artinger, K. and Eller, K. and Caamano, J. and Ruelicke, T. and Moss, P. and Megens, R.T.A. and von Andrian, U.H. and Hidalgo, A. and Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.
Young, E. and Noerenberg, D. and Mansouri, L. and Ljungström, V. and Frick, M. and Sutton, L.A. and Blakemore, S.J. and Galan-Sousa, J. and Plevova, K. and Baliakas, P. and Rossi, D. and Clifford, R. and Roos-Weil, D. and Navrkalova, V. and Dörken, B. and Schmitt, C.A. and Smedby, K.E. and Juliusson, G. and Giacopelli, B. and Blachly, J.S. and Belessi, C. and Panagiotidis, P. and Chiorazzi, N. and Davi, F. and Langerak, A.W. and Oscier, D. and Schuh, A. and Gaidano, G. and Ghia, P. and Xu, W. and Fan, L. and Bernard, O.A. and Nguyen-Khac, F. and Rassenti, L. and Li, J. and Kipps, T.J. and Stamatopoulos, K. and Pospisilova, S. and Zenz, T. and Oakes, C.C. and Strefford, J.C. and Rosenquist, R. and Damm, F.
Leukemia 31 (7): 1547-1554. July 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.
Kar, G. and Kim, J.K. and Kolodziejczyk, A.A. and Natarajan, K.N. and Torlai Triglia, E. and Mifsud, B. and Elderkin, S. and Marioni, J.C. and Pombo, A. and Teichmann, S.A.
Nature Communications 8 (1): 36. 26 June 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F. and Rapp, A. and Yu, W. and Maiser, A. and Harz, H. and Scholl, A. and Grulich, S. and Anton, T. and Hoerl, D. and Chen, W. and Durante, M. and Taucher-Scholz, G. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G. and Raffel, S. and Sormani, M. and Zanardi, F. and Lonardi, S. and Zasada, C. and Perucho, L. and Petrocelli, V. and Haake, A. and Lee, A.K. and Bugatti, M. and Paul, U. and Van Anken, E. and Pasqualucci, L. and Rabadan, R. and Siebert, R. and Kempa, S. and Ponzoni, M. and Facchetti, F. and Rajewsky, K. and Casola, S.
Nature 546 (7657): 302-306. 8 June 2017

RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
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Nucleic Acids Research 45 (10): e91. 2 June 2017

Tracking the evolution of non-small-cell lung cancer.
Jamal-Hanjani, M. and Wilson, G.A. and McGranahan, N. and Birkbak, N.J. and Watkins, T.B.K. and Veeriah, S. and Shafi, S. and Johnson, D.H. and Mitter, R. and Rosenthal, R. and Salm, M. and Horswell, S. and Escudero, M. and Matthews, N. and Rowan, A. and Chambers, T. and Moore, D.A. and Turajlic, S. and Xu, H. and Lee, S.-M. and Forster, M.D. and Ahmad, T. and Hiley, C.T. and Abbosh, C. and Falzon, M. and Borg, E. and Marafioti, T. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P.A. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Dentro, S. and Taniere, P. and O'Sullivan, B. and Lowe, H.L. and Hartley, J.A. and Iles, N. and Bell, H. and Ngai, Y. and Shaw, J.A. and Herrero, J. and Szallasi, Z. and Schwarz, R.F. and Stewart, A. and Quezada, S.A. and Le Quesne, J. and Van Loo, P. and Dive, C. and Hackshaw, A. and Swanton, C.
New England Journal of Medicine 376 (22): 2109-2121. 1 June 2017

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.
Barbieri, M. and Xie, S.Q. and Torlai Triglia, E. and Chiariello, A.M. and Bianco, S. and de Santiago, I. and Branco, M.R. and Rueda, D. and Nicodemi, M. and Pombo, A.
Nature Structural & Molecular Biology 24 (6): 515-524. June 2017

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Tay, T.L. and Mai, D. and Dautzenberg, J. and Fernández-Klett, F. and Lin, G. and Sagar, D.M. and Datta, M. and Drougard, A. and Stempfl, T. and Ardura-Fabregat, A. and Staszewski, O. and Margineanu, A. and Sporbert, A. and Steinmetz, L.M. and Pospisilik, J.A. and Jung, S. and Priller, J. and Grün, D. and Ronneberger, O. and Prinz, M.
Nature Neuroscience 20 (6): 793-803. June 2017

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M. and Zerbes, R.M. and Rampelt, H. and Kunz, S. and Xavier, A.H. and Purfürst, B. and Lilie, H. and Pfanner, N. and van der Laan, M. and Daumke, O.
Nature Communications 8 : 15258. 31 May 2017

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Nature 545 (7655): 446-451. 25 May 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. and Schönheit, J. and Giladi, A. and David, E. and Lara-Astiaso, D. and Lorenzo-Vivas, E. and Paul, F. and Chappell-Maor, L. and Priller, J. and Leutz, A. and Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I. and Termglinchan, V. and Cepeda, D.A. and Lee, J. and Diecke, S. and Hendel, A. and Itzhaki, I. and Ameen, M. and Shrestha, R. and Wu, H. and Ma, N. and Shao, N.Y. and Seeger, T. and Woo, N.A. and Wilson, K.D. and Matsa, E. and Porteus, M.H. and Sebastiano, V. and Wu, J.C.
Circulation Research 120 (10): 1561-1571. 12 May 2017

Keep them close: PRC2 poises enhancer-promoter interactions at anterior neuronal genes.
Caglio, Giulia and Torlai Triglia, E. and Pombo, A.
Cell Stem Cell 20 (5): 573-575. 4 May 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K. and Daub, S. and Zhang, Y. and Klein, J. D. and Nakano, D. and Pedchenko, T. and Lantier, L. and LaRocque, L.M. and Marton, A. and Neubert, P. and Schröder, A. and Rakova, N. and Jantsch, J. and Dikalova, A.E. and Dikalov, S.I. and Harrison, D.G. and Müller, D.N. and Nishiyama, A. and Rauh, M. and Harris, R. C. and Luft, F.C. and Wassermann, D.H. and Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127 (5): 1944-1959. 1 May 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N. and Kitada, K. and Lerchl, K. and Dahlmann, A. and Birukov, A. and Daub, S. and Kopp, C. and Pedchenko, T. and Zhang, Y. and Beck, L. and Johannes, B. and Marton, A. and Müller, D.N. and Rauh, M. and Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127 (5): 1932-1943. 1 May 2017

Pancreatic cancer models for translational research.
Behrens, D. and Walther, W. and Fichtner, I.
Pharmacology & Therapeutics 173 : 146-158. May 2017

Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
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Journal of the American Chemical Society 139 (16): 5640-5643. 26 April 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S. and Zharkov, D.O. and Stahl, J. and Gopanenko, Al.V. and Tupikin, A.E. and Kabilov, M.R. and Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45 (7): 3833-3843. 20 April 2017

Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.
Legnini, I. and Di Timoteo, G. and Rossi, F. and Morlando, M. and Briganti, F. and Sthandier, O. and Fatica, A. and Santini, T. and Andronache, A. and Wade, M. and Laneve, P. and Rajewsky, N. and Bozzoni, I.
Molecular Cell 66 (1): 22-37.e9. 6 April 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Initiation of acute graft-versus-host disease by angiogenesis.
Riesner, K. and Shi, Y. and Jacobi, A. and Kräter, M. and Kalupa, M. and McGearey, A. and Mertlitz, S. and Cordes, S. and Schrezenmeier, J.F. and Mengwasser, J. and Westphal, S. and Perez-Hernandez, D. and Schmitt, C. and Dittmar, G. and Guck, J. and Penack, O.
Blood 129 (14): 2021-2032. 6 April 2017

Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing, S. and Rudnik, S. and Damme, M. and Luellmann-Rauch, R. and Ichihara, A. and Kornak, U. and Eskelinen, E.L. and Jabs, S. and Heeren, J. and De Brabander, J.K. and Haas, A. and Saftig, P.
Autophagy 13 (4): 670-685. April 2017

Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie, R.A. and Scialdone, A. and Schueler, M. and Kraemer, D.C.A. and Chotalia, M. and Xie, S.Q. and Barbieri, M. and de Santiago, I. and Lavitas, L.M. and Branco, M.R. and Fraser, J. and Dostie, J. and Game, L. and Dillon, N. and Edwards, P.A.W. and Nicodemi, M. and Pombo, A.
Nature 543 (7646): 519-524. 23 March 2017

Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O. and de Jong, T. and Mata-Cabana, A. and Kudron, M. and Zaini, M.A. and Aprile, F.A. and Seinstra, R.I. and Stroo, E. and Prins, R.W. and Martineau, C.N. and Wang, H.H. and Hogewerf, Wytse and Steinhof, A. and Wanker, E.E. and Vendruscolo, M. and Calkhoven, C.F. and Reinke, V. and Guryev, V. and Nollen, E.A.A.
Molecular Cell 65 (6): 1096-1108. 16 March 2017

The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association.
Mancia, G. and Oparil, S. and Whelton, P.K. and McKee, M. and Dominiczak, A. and Luft, F.C. and AlHabib, K. and Lanas, F. and Damasceno, A. and Prabhakaran, D. and La Torre, G. and Weber, M. and O'Donnell, M. and Smith, S.C. and Narula, J.
European Heart Journal 38 (10): 712-719. 7 March 2017

Pericytes or mesenchymal stem cells: is that the question?
Cano, E. and Gebala, V. and Gerhardt, H.
Cell Stem Cell 20 (3): 296-297. 2 March 2017

Deciphering the ubiquitin code.
Dittmar, G. and Selbach, M.
Molecular Cell 65 (5): 779-780. 2 March 2017

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D. and Hummel, F. and Richter, J. and Giefing, M. and Hartmann, S. and Hansmann, M.L. and Kreher, S. and Köchert, K. and Krappmann, D. and Klapper, W. and Hummel, M. and Wenzel, S.S. and Lenz, G. and Janz, M. and Dörken, B. and Siebert, R. and Mathas, S.
Leukemia 31 (3): 602-613. March 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N. and Naumann, H. and Ruzittu, S. and Mah, N. and Pongrac, I.M. and Cozzitorto, C. and Hommel, A. and Andrade-Navarro, M.A. and Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

A finer print than TADs: PRC1-mediated domains.
Torlai Triglia, E. and Rito, Tiago and Pombo, A.
Molecular Cell 65 (3): 373-375. 2 February 2017

A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells.
Velasco, S. and Ibrahim, M.M. and Kakumanu, A. and Garipler, G. and Aydin, B. and Al-Sayegh, M.A. and Hirsekorn, A. and Abdul-Rahman, F. and Satija, R. and Ohler, U. and Mahony, S. and Mazzoni, E.O.
Cell Stem Cell 20 (2): 205-217. 2 February 2017

Scattering compensation by focus scanning holographic aberration probing (F-SHARP).
Papadopoulos, I.N. and Jouhanneau, J.S. and Poulet, J.F.A. and Judkewitz, B.
Nature Photonics 11 (2): 116-123. February 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C. and Pifferi, S. and Picci, C. and Gök, C. and Hoffmann, D. and Bali, K.K. and Lampe, A. and Lapatsina, L. and Fleischer, R. and Smith, E.S.J. and Bégay, V. and Moroni, M. and Estebanez, L. and Kühnemund, J. and Walcher, J. and Specker, E. and Neuenschwander, M. and von Kries, J.P. and Haucke, V. and Kuner, R. and Poulet, J.F.A. and Schmoranzer, J. and Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

Microglia in physiology and disease.
Wolf, S.A. and Boddeke, H.W.G.M. and Kettenmann, H.
Annual Review of Physiology 79 : 619-643. February 2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S. and Childs, L.H. and Aust, D. and Heim, D. and Melching, F. and Oliveira, C. and Wolf, T. and Durek, P. and Schumacher, D. and Blaeker, H. and von Winterfeld, M. and Gastl, B. and Moehr, K. and Menne, A. and Zeugner, S. and Redmer, T. and Lenze, D. and Tierling, S. and Moebs, M. and Weichert, W. and Folprecht, G. and Blanc, E. and Beule, D. and Schaefer, R. and Morkel, M. and Klauschen, F. and Leser, U. and Sers, C.
Nature Communications 8 : 14093. 25 January 2017

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M. and Kirchner, M. and Aharoni, R. and Ciolli Mattioli, C. and van den Bruck, D. and Gutkovitch, N. and Modepalli, V. and Selbach, M. and Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45 (2): 938-950. 25 January 2017

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Dehghani Amirabad, A. and Behjati Ardakani, F. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
Nucleic Acids Research 45 (1): 54-66. 9 January 2017

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y. and Pryputniewicz-Dobrinska, D. and Nagy, E.E. and Kaufman, C.D. and Singh, M. and Yant, S. and Wang, J. and Dalda, A. and Kay, M.A. and Ivics, Z. and Izsvák, Z.
Nucleic Acids Research 45 (1): 311-326. 9 January 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 5 January 2017

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A. and Gorham, L. and Dhandapani, R. and Prato, V. and Taberner, F.J. and Wende, H. and Gangadharan, V. and Birchmeier, C. and Heppenstall, P.A. and Lechner, S.G.
Neuron 93 (1): 179-193. 4 January 2017

OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines.
Chen, W.H. and Lu, G. and Chen, X. and Zhao, X.M. and Bork, P.
Nucleic Acids Research 45 (D1): D940-D944. 4 January 2017

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
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Nucleic Acids Research 45 (D1): D529-D534. 4 January 2017

The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Szklarczyk, D. and Morris, J.H. and Cook, H. and Kuhn, M. and Wyder, S. and Simonovic, M. and Santos, A. and Doncheva, N.T. and Roth, A. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 45 (D1): D362-D368. 4 January 2017

Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Hoepken, U.E.
Cancer Discovery 7 (1): 14-16. January 2017

Integrative classification of human coding and noncoding genes through RNA metabolism profiles.
Mukherjee, N. and Calviello, L. and Hirsekorn, A. and de Pretis, S. and Pelizzola, M. and Ohler, U.
Nature Structural & Molecular Biology 24 (1): 86-96. January 2017

Titin-truncating variants affect heart function in disease cohorts and the general population.
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Nature Genetics 49 (1): 46-53. January 2017


Stefan Jentsch (1955-2016) Obituary.
Sommer, T. and Hoppe, T. and Rape, M.
Cell Press. 15 December 2016

Stefan Jentsch (1955-2016) Obituary.
Sommer, T. and Hoppe, T. and Rape, M.
Cell Press. 15 December 2016

How to manage the obese patient with cancer.
Renehan, A.G. and Harvie, M. and Cutress, R.I. and Leitzmann, M. and Pischon, T. and Howell, S. and Howell, A.
Journal of Clinical Oncology 34 (35): 4284-4294. 10 December 2016

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S. and Bolcho, U. and Molgaard, S. and Bøggild, S. and Vaegter, C.B. and Smith, A.H. and Nieto-Gonzalez, J.L. and Ovesen, P.L. and Pedersen, L.F. and Fjorback, A.N. and Kjolby, M. and Login, H. and Holm, M.M. and Andersen, O.M. and Nyengaard, J.R. and Willnow, T.E. and Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21 (12): 1740-1751. December 2016

DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L. and Nanda, I. and Evangelou, K. and Nikolova, T. and Horn, V. and Sagar, and Erny, D. and Stefanowski, J. and Rogell, L. and Klein, C. and Gharun, K. and Follo, M. and Seidl, M. and Kremer, B. and Münke, N. and Senges, J. and Fliegauf, M. and Aschman, T. and Pfeifer, D. and Sarrazin, S. and Sieweke, M.H. and Wagner, D. and Dierks, C. and Haaf, T. and Ness, T. and Zaiss, M.M. and Voll, R.E. and Deshmukh, S.D. and Prinz, M. and Goldmann, T. and Hölscher, C. and Hauser, A.E. and Lopez-Contreras, A.J. and Grün, D. and Gorgoulis, V. and Diefenbach, A. and Henneke, P. and Triantafyllopoulou, A.
Cell 167 (5): 1264-1280. 17 November 2016

The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Stunnenberg, H.G. and Hirst, M.
Cell 167 (7): 1145-1149. 17 November 2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
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In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
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G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch.
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Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
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Acta Neuropathologica 132 (5): 653-665. November 2016

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
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Nature Communications 7 : 13314. 31 October 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
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Kinetic analysis of protein stability reveals age-dependent degradation.
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Cell 167 (3): 803-815. 20 October 2016

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
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Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice.
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Formation of new chromatin domains determines pathogenicity of genomic duplications.
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Nature 538 (7624): 265-269. 13 October 2016

Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
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Blood 128 (15): 1928-1939. 13 October 2016

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
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Cancer Cell 30 (4): 519-532. 10 October 2016

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
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Bimodal antagonism of PKA signalling by ARHGAP36.
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Nature Communications 7 : 12963. 7 October 2016

A glycolytic solution for pluripotent stem cells.
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Cell Stem Cell 19 (4): 419-420. 6 October 2016

Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
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Journal of the American Chemical Society 138 (39): 12868-12875. 5 October 2016

Axial tubule junctions control rapid calcium signaling in atria.
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Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
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Brain 139 (10): 2641-2652. 1 October 2016

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
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Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
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Nature Medicine 22 (10): 1140-1150. October 2016

Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
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Nature 537 (7622): 689-693. 29 September 2016

52 genetic loci influencing myocardial mass.
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Journal of the American College of Cardiology 68 (13): 1435-1448. 27 September 2016

Eyes on translation.
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Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
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Molecular Cell 63 (5): 827-839. 1 September 2016

Circular RNAs in brain and other tissues: a functional enigma.
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Trends in Neurosciences 39 (9): 597-604. September 2016

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
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Nature Methods 13 (9): 741-748. September 2016

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.
Sarnowski, C. and Laprise, C. and Malerba, G. and Moffatt, M.F. and Dizier, M.H. and Morin, A. and Vincent, Q.B. and Rohde, K. and Esparza-Gordillo, J. and Margaritte-Jeannin, P. and Liang, L. and Lee, Y.A. and Bousquet, J. and Siroux, V. and Pignatti, P.F. and Cookson, W.O. and Lathrop, M. and Pastinen, T. and Demenais, F. and Bouzigon, E.
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The persistent dynamic secrets of senescence.
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Nature Cell Biology 18 (9): 913-915. September 2016

Microglia development follows a stepwise program to regulate brain homeostasis.
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Science 353 (6301): aad8670. 19 August 2016

OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
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Molecular Cell 63 (4): 647-661. 18 August 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
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Nature Communications 7 : 12514. 17 August 2016

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.
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Nature Cell Biology 18 (8): 864-875. August 2016

Risk factors: evolving epidemiology of sodium intake and CVD.
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Nature Reviews Cardiology 13 (8): 445-446. August 2016

Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
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Journal of the American Chemical Society 138 (29): 9109-9118. 27 July 2016

Human gut microbes impact host serum metabolome and insulin sensitivity.
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Nature 535 (7612): 376-381. 21 July 2016

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Nature Communications 7 : 12240. 20 July 2016

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
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Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.
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Nucleic Acids Research 44 (W1): W242-W245. 8 July 2016

Wars2 is a determinant of angiogenesis.
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SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
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The mRNA-bound proteome of the early fly embryo.
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Nature Communications 7 : 12039. 30 June 2016

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The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation.
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Phase II trial of temsirolimus for relapsed/refractory primary CNS lymphoma.
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Eosinophils and mast cells: a lineage apart.
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Nature Immunology 17 (6): 609-611. 19 May 2016

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus.
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Neuron 90 (4): 795-809. 18 May 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
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Crimea report leaves readers in the cold.
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Standardized benchmarking in the quest for orthologs.
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Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
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Orchestrating Wnt signalling for metabolic liver zonation.
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VRACs and other ion channels and transporters in the regulation of cell volume and beyond.
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Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets.
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IL-33 in T cell differentiation, function, and immune homeostasis.
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Plankton networks driving carbon export in the oligotrophic ocean.
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4D visualization of replication foci in mammalian cells corresponding to individual replicons.
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Radioimmunotherapy in relapsed/refractory mantle cell lymphoma patients: final results of a European MCL network phase II trial.
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Cellular and system biology of memory: Timing, molecules, and beyond.
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Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton.
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A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
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Targeting human melanoma neoantigens by T cell receptor gene therapy.
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Integration of multi-omics data of a genome-reduced bacterium: prevalence of post-transcriptional regulation and its correlation with protein abundances.
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Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
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Genome-wide polyadenylation maps reveal dynamic mRNA 3'-end formation in the failing human heart.
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Detecting actively translated open reading frames in ribosome profiling data.
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Immunological memory: lessons from the past and a look to the future.
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Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
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Nature Protocols 11 (2): 327-346. February 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
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Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
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Nature Communications 7 : 10286. 8 January 2016

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
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The SIDER database of drugs and side effects.
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Nucleic Acids Research 44 (D1): D1075-D1079. 4 January 2016

STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.
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The role of microglia and macrophages in glioma maintenance and progression.
Hambardzumyan, D. and Gutmann, D.H. and Kettenmann, H.
Nature Neuroscience 19 (1): 20-27. January 2016

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
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Molecular Psychiatry 21 (1): 133-148. January 2016

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
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The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
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Annals of the Rheumatic Diseases 75 (1): 260-268. January 2016


Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.
Fraser, J. and Ferrai, C. and Chiariello, A.M. and Schueler, M. and Rito, T. and Laudanno, G. and Barbieri, M. and Moore, B.L. and Kraemer, D.C.A. and Aitken, S. and Xie, S.Q. and Morris, K.J. and Itoh, M. and Kawaji, H. and Jaeger, I. and Hayashizaki, Y. and Carninci, P. and Forrest, A.R.R. and Semple, C.A. and Dostie, J. and Pombo, A. and Nicodemi, M.
Molecular Systems Biology 11 (12): 852. 23 December 2015

PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
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Immunity 43 (6): 1075-1086. 15 December 2015

A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer.
von Eyss, B. and Jaenicke, L.A. and Kortlever, R.M. and Royla, N. and Wiese, K.E. and Letschert, S. and McDuffus, L.A. and Sauer, M. and Rosenwald, A. and Evan, G.I. and Kempa, S. and Eilers, M.
Cancer Cell 28 (6): 743-757. 14 December 2015

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
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Nature 528 (7581): 262-266. 10 December 2015

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
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Nature Immunology 16 (12): 1235-1244. December 2015

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
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Nature Genetics 47 (12): 1449-1456. December 2015

Optogenetic acidification of synaptic vesicles and lysosomes.
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Nature Neuroscience 18 (12): 1845-1852. December 2015

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. and Chu, V.T.
Genome Biology 16 (1): 244. 10 November 2015

Meta-analysis identifies seven susceptibility loci involved in the atopic march.
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Nature Communications 6 : 8804. 6 November 2015

Operon structure and cotranslational subunit association direct protein assembly in bacteria.
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Science 350 (6261): 678-680. 6 November 2015

Perspectives on unidirectional versus divergent transcription.
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Molecular Cell 60 (3): 348-349. 5 November 2015

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J. and Gebhardt, M. and Heinig, M. and Rintisch, C. and Schroeder, A. and Neuhofer, W. and Hilgers, K. and Manzel, A. and Schwartz, C. and Kleinewietfeld, M. and Voelkl, J. and Schatz, V. and Linker, R.A. and Lang, F. and Voehringer, D. and Wright, M.D. and Hubner, N. and Dechend, R. and Jantsch, J. and Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125 (11): 4223-4238. 2 November 2015

Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N. and Jae, N. and Heumueller, A.W. and Chen, W. and Boon, R.A. and Stellos, K. and Zeiher, A.M. and John, D. and Uchida, S. and Dimmeler, S.
Circulation Research 117 (10): 884-890. 23 October 2015

Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A. and Sozzani, R. and Yardımcı, G.G. and Petricka, J.J. and Vernoux, T. and Blilou, I. and Alonso, J. and Winter, C.M. and Ohler, U. and Scheres, B. and Benfey, P.N.
Science 350 (6259): 426-430. 23 October 2015

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A. and Jörg, S. and Duscha, A. and Berg, J. and Manzel, A. and Waschbisch, A. and Hammer, A. and Lee, D.H. and May, C. and Wilck, N. and Balogh, A. and Ostermann, A.I. and Schebb, N.H. and Akkad, D.A. and Grohme, D.A. and Kleinewietfeld, M. and Kempa, S. and Thöne, J. and Demir, S. and Müller, D.N. and Gold, R. and Linker, R.A.
Immunity 43 (4): 817-829. 20 October 2015

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.
Feutlinske, F. and Browarski, M. and Ku, M.C. and Trnka, P. and Waiczies, S. and Niendorf, T. and Stallcup, W.B. and Glass, R. and Krause, E. and Maritzen, T.
Nature Communications 6 : 8535. 5 October 2015

T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice.
Dargel, C. and Bassani-Sternberg, M. and Hasreiter, J. and Zani, F. and Bockmann, J.H. and Thiele, F. and Bohne, F. and Wisskirchen, K. and Wilde, S. and Sprinzl, M.F. and Schendel, D.J. and Krackhardt, A.M. and Uckert, W. and Wohlleber, D. and Schiemann, M. and Stemmer, K. and Heikenwälder, M. and Busch, D.H. and Richter, G. and Mann, M. and Protzer, U.
Gastroenterology 149 (4): 1042-1052. October 2015

Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years.
Grabenhenrich, L.B. and Keil, T. and Reich, A. and Gough, H. and Beschorner, J. and Hoffmann, U. and Bauer, C.P. and Forster, J. and Schuster, A. and Schramm, D. and Nitsche, O. and Zepp, F. and Lee, Y.A. and Bergmann, R. and Bergmann, K. and Wahn, U. and Lau, S.
Journal of Allergy and Clinical Immunology 136 (4): 932-940. October 2015

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
Gimber, N. and Tadeus, G. and Maritzen, T. and Schmoranzer, J. and Haucke, V.
Nature Communications 6 : 8392. 24 September 2015

Crystal structure of the dynamin tetramer.
Reubold, T.F. and Faelber, K. and Plattner, N. and Posor, Y. and Ketel, K. and Curth, U. and Schlegel, J. and Anand, R. and Manstein, D.J. and Noé, F. and Haucke, V. and Daumke, O. and Eschenburg, S.
Nature 525 (7569): 404-408. 17 September 2015

Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D. and Zauber, H. and Bielow, C. and Thiel, D. and Kutz, K. and Calviello, L. and Mastrobuoni, G. and Rajewsky, N. and Kempa, S. and Selbach, M. and Obermayer, B.
Genome Biology 16 : 179. 14 September 2015

Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in klatskin tumor patients.
Lederer, A. and Herrmann, P. and Seehofer, D. and Dietel, M. and Pratschke, J. and Schlag, P. and Stein, U.
Hepatology 62 (3): 841-850. September 2015

A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.
Schaarschmidt, H. and Ellinghaus, D. and Rodríguez, E. and Kretschmer, A. and Baurecht, H. and Lipinski, S. and Meyer-Hoffert, U. and Harder, J. and Lieb, W. and Novak, N. and Fölster-Holst, R. and Esparza-Gordillo, J. and Marenholz, I. and Ruschendorf, F. and Hubner, N. and Reischl, E. and Waldenberger, M. and Gieger, C. and Illig, T. and Kabesch, M. and Zhang, X.J. and Xiao, F.L. and Lee, Y.A. and Franke, A. and Weidinger, S.
Journal of Allergy and Clinical Immunology 136 (3): 802-806. September 2015

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T. and Chopra, A. and Nafissi, N. and Polacheck, W.J. and Benson, C.C. and Swist, S. and Gorham, J. and Yang, L. and Schafer, S. and Sheng, C.C. and Haghighi, A. and Homsy, J. and Hubner, N. and Church, G. and Cook, S.A. and Linke, W.A. and Chen, C.S. and Seidman, J.G. and Seidman, C.E.
Science 349 (6251): 982-986. 28 August 2015

Extensive allele-specific translational regulation in hybrid mice.
Hou, J. and Wang, X. and McShane, E. and Zauber, H. and Sun, W. and Selbach, M. and Chen, W.
Molecular Systems Biology 11 (8): 825. 7 August 2015

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C. and Rosser, J.M. and Newkirk, S.J. and Yin, J. and Jiang, X. and Xing, Z. and Whitmore, L. and Bashir, S. and Ivics, Z. and Izsvák, Z. and Ye, P. and Yu, Y.E. and An, W.
Genome Research 25 (8): 1135-1146. August 2015

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A. and Prigione, A. and Cramer, T. and Wamelink, M.M.C. and Campbell, K. and Cheung, E. and Olin-Sandoval, V. and Gruening, N.M. and Krueger, A. and Tauqeer Alam, M. and Keller, M.A. and Breitenbach, M. and Brindle, K.M. and Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90 (3): 927-963. August 2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H. and Chivite, I. and Angulo-Urarte, A. and Soler, A. and Sutherland, J.D. and Arruabarrena-Aristorena, A. and Ragab, A. and Lim, R. and Malumbres, M. and Fruttiger, M. and Potente, M. and Serrano, M. and Fabra, A. and Vinals, F. and Casanovas, O. and Pandolfi, P.P. and Bigas, A. and Carracedo, A. and Gerhardt, H. and Graupera, M.
Nature Communications 6 : 7935. 31 July 2015

New role for the (pro)renin receptor in T cell development.
Geisberger, S. and Maschke, U. and Gebhardt, M. and Kleinewietfeld, M. and Manzel, A. and Linker, R.A. and Chidgey, A. and Dechend, R. and Nguyen, G. and Daumke, O. and Muller, D.N. and Wright, M.D. and Binger, K.J.
Blood 126 (4): 504-507. 23 July 2015

Matching cell type to function in cortical circuits.
Estebanez, L. and Kremkow, J. and Poulet, J.F.A.
Neuron 87 (2): 249-251. 15 July 2015

Wiring the vascular network with neural cues: a CNS perspective.
Waächli, T. and Wacker, A. and Frei, K. and Regli, L. and Schwab, M.E. and Hoerstrup, S.P. and Gerhardt, H. and Engelhardt, B.
Neuron 87 (2): 271-296. 15 July 2015

Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c.
Wiegreffe, C. and Simon, R. and Peschkes, K. and Kling, C. and Strehle, M. and Cheng, J. and Srivatsa, S. and Liu, P. and Jenkins, N.A. and Copeland, N.G. and Tarabykin, V. and Britsch, S.
Neuron 87 (2): 311-325. 15 July 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML-Study IV.
Saussele, S. and Krauss, M.P. and Hehlmann, R. and Lauseker, M. and Proetel, U. and Kalmanti, L. and Hanfstein, B. and Fabarius, A. and Kraemer, D. and Berdel, W.E. and Bentz, M. and Staib, P. and de Wit, M. and Wernli, M. and Zettl, F. and Hebart, H.F. and Hahn, M. and Heymanns, J. and Schmidt-Wolf, I. and Schmitz, N. and Eckart, M.J. and Gassmann, W. and Bartholomaeus, A. and Pezzutto, A. and Oppliger Leibundgut, E. and Heim, D. and Krause, S.W. and Burchert, A. and Hofmann, W.K. and Hasford, J. and Hochhaus, A. and Pfirrmann, M. and Müller, M.C.
Blood 126 (1): 42-49. 2 July 2015

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao, Q. and Sun, W. and Ballegeer, M. and Libert, C. and Chen, W.
Molecular Systems Biology 11 (7): 816. 1 July 2015

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E. and Iwata, A. and Albring, J. and Wu, X. and Tussiwand, R. and Kc, W. and Kretzer, N.M. and Briseno, C.G. and Durai, V. and Bagadia, P. and Haldar, M. and Schoenheit, J. and Rosenbauer, F. and Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes.
Pfeifer, M. and Zheng, B. and Erdmann, T. and Koeppen, H. and McCord, R. and Grau, M. and Staiger, A. and Chai, A. and Sandmann, T. and Madle, H. and Doerken, B. and Chu, Y.W. and Chen, A.I. and Lebovic, D. and Salles, G.A. and Czuczman, M.S. and Palanca-Wessels, M.C. and Press, O.W. and Advani, R. and Morschhauser, F. and Cheson, B.D. and Lenz, P. and Ott, G. and Polson, A.G. and Mundt, K.E. and Lenz, G.
Leukemia 29 (7): 1578-1586. July 2015

Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial.
Pelzer, U. and Opitz, B. and Deutschinoff, G. and Stauch, M. and Reitzig, P.C. and Hahnfeld, S. and Mueller, L. and Grunewald, M. and Stieler, J.M. and Sinn, M. and Denecke, T. and Bischoff, S. and Oettle, H. and Doerken, B. and Riess, H.
Journal of Clinical Oncology 33 (18): 2028-2034. 20 June 2015

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Aspalter, I.M. and Gordon, E. and Dubrac, A. and Ragab, A. and Narloch, J. and Vizán, P. and Geudens, I. and Collins, R.T. and Franco, C.A. and Abrahams, C.L. and Thurston, G. and Fruttiger, M. and Rosewell, I. and Eichmann, A. and Gerhardt, H.
Nature Communications 6 : 7264. 17 June 2015

Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed.
Rybak-Wolf, A. and Stottmeister, C. and Glažar, P. and Jens, M. and Pino, N. and Giusti, S. and Hanan, M. and Behm, M. and Bartok, O. and Ashwal-Fluss, R. and Herzog, M. and Schreyer, L. and Papavasileiou, P. and Ivanov, A. and Öhman, M. and Refojo, D. and Kadener, S. and Rajewsky, N.
Molecular Cell 58 (5): 870-885. 4 June 2015

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
Lim, H.W. and Uhlenhaut, N.H. and Rauch, A. and Weiner, J. and Hübner, S. and Hübner, N. and Won, K.J. and Lazar, M.A. and Tuckermann, J. and Steger, D.J.
Genome Research 25 (6): 836-844. June 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G. and Aydin, A. and Luft, F.C. and Schächterle, C. and Weise, A. and Stricker, S. and Lindschau, C. and Vaegler, M. and Qadri, F. and Toka, H.R. and Schulz, H. and Krawitz, P.M. and Parkhomchuk, D. and Hecht, J. and Hollfinger, I. and Wefeld-Neuenfeld, Y. and Bartels-Klein, E. and Mühl, A. and Kann, M. and Schuster, H. and Chitayat, D. and Bialer, M.G. and Wienker, T.F. and Ott, J. and Rittscher, K. and Liehr, T. and Jordan, J. and Plessis, G. and Tank, J. and Mai, K. and Naraghi, R. and Hodge, R. and Hopp, M. and Hattenbach, L.O. and Busjahn, A. and Rauch, A. and Vandeput, F. and Gong, M. and Rüschendorf, F. and Hübner, N. and Haller, H. and Mundlos, S. and Bilginturan, N. and Movsesian, M.A. and Klussmann, E. and Toka, O. and Bähring, S.
Nature Genetics 47 (6): 647-653. June 2015

A multiplexed NMR-reporter approach to measure cellular kinase and phosphatase activities in real-time.
Thongwichian, R. and Kosten, J. and Benary, U. and Rose, H.M. and Stuiver, M. and Theillet, F.X. and Dose, A. and Koch, B. and Yokoyama, H. and Schwarzer, D. and Wolf, J. and Selenko, P.
Journal of the American Chemical Society 137 (20): 6468-6471. 27 May 2015

Translational regulation shapes the molecular landscape of complex disease phenotypes.
Schafer, S. and Adami, E. and Heinig, M. and Costa Rodrigues, K.E. and Kreuchwig, F. and Silhavy, J. and van Heesch, S. and Simaite, D. and Rajewsky, N. and Cuppen, E. and Pravenec, M. and Vingron, M. and Cook, S.A. and Hubner, N.
Nature Communications 6 : 7200. 26 May 2015

Patterns and ecological drivers of ocean viral communities.
Brum, J.R. and Ignacio-Espinoza, J.C. and Roux, S. and Doulcier, G. and Acinas, S.G. and Alberti, A. and Chaffron, S. and Cruaud, C. and de Vargas, C. and Gasol, J.M. and Gorsky, G. and Gregory, A.C. and Guidi, L. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Poulos, B.T. and Schwenck, S.M. and Speich, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Bork, P. and Bowler, C. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Sullivan, M.B.
Science 348 (6237): 1261498. 22 May 2015

Determinants of community structure in the global plankton interactome.
Lima-Mendez, G. and Faust, K. and Henry, N. and Decelle, J. and Colin, S. and Carcillo, F. and Chaffron, S. and Ignacio-Espinosa, J.C. and Roux, S. and Vincent, F. and Bittner, L. and Darzi, Y. and Wang, J. and Audic, S. and Berline, L. and Bontempi, G. and Cabello, A.M. and Coppola, L. and Cornejo-Castillo, F.M. and d' Ovidio, F. and De Meester, L. and Ferrera, I. and Garet-Delmas, M.J. and Guidi, L. and Lara, E. and Pesant, S. and Royo-Llonch, M. and Salazar, G. and Sanchez, P. and Sebastian, M. and Souffreau, C. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Gorsky, G. and Not, F. and Ogata, H. and Speich, S. and Stemmann, L. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Sunagawa, S. and Bork, P. and Sullivan, M.B. and Karsenti, E. and Bowler, C. and de Vargas, C. and Raes, J.
Science 348 (6237): 1262073. 22 May 2015

Structure and function of the global ocean microbiome.
Sunagawa, S. and Coelho, L.P. and Chaffron, S. and Kultima, J.R. and Labadie, K. and Salazar, G. and Djahanschiri, B. and Zeller, G. and Mende, D.R. and Alberti, A. and Cornejo-Castillo, F.M. and Costea, P.I. and Cruaud, C. and d'Ovidio, F. and Engelen, S. and Ferrera, I. and Gasol, J.M. and Guidi, L. and Hildebrand, F. and Kokoszka, F. and Lepoivre, C. and Lima-Mendez, G. and Poulain, J. and Poulos, B.T. and Royo-Llonch, M. and Sarmento, H. and Vieira-Silva, S. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Bowler, C. and de Vargas, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Jaillon, O. and Not, F. and Ogata, H. and Pesant, S. and Speich, S. and Stemmann, L. and Sullivan, M.B. and Weissenbach, J. and Wincker, P. and Karsenti, E. and Raes, J. and Acinas, S.G. and Bork, P.
Science 348 (6237): 1261359. 22 May 2015

Environmental characteristics of Agulhas rings affect interocean plankton transport.
Villar, E. and Farrant, G.K. and Follows, M. and Garczarek, L. and Speich, S. and Audic, S. and Bittner, L. and Blanke, B. and Brum, J.R. and Brunet, C. and Casotti, R. and Chase, A. and Dolan, J.R. and d'Ortenzio, F. and Gattuso, J.P. and Grima, N. and Guidi, L. and Hill, C.N. and Jahn, O. and Jamet, J.L. and Le Goff, H. and Lepoivre, C. and Malviya, S. and Pelletier, E. and Romagnan, J.B. and Roux, S. and Santini, S. and Scalco, E. and Schwenck, S.M. and Tanaka, A. and Testor, P. and Vannier, T. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Boss, E. and de Vargas, C. and Gorsky, G. and Ogata, H. and Pesant, S. and Sullivan, M.B. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Bowler, C. and Not, F. and Hingamp, P. and Iudicone, D.
Science 348 (6237): 1261447. 22 May 2015

Eukaryotic plankton diversity in the sunlit ocean.
de Vargas, C. and Audic, S. and Henry, N. and Decelle, J. and Mahe, F. and Logares, R. and Lara, E. and Berney, C. and Le Bescot, N. and Probert, I. and Carmichael, M. and Poulain, J. and Romac, S. and Colin, S. and Aury, J.M. and Bittner, L. and Chaffron, S. and Dunthorn, M. and Engelen, S. and Flegontova, O. and Guidi, L. and Horak, A. and Jaillon, O. and Lima-Mendez, G. and Lukes, J. and Malviya, S. and Morard, R. and Mulot, M. and Scalco, E. and Siano, R. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Bowler, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Raes, J. and Sieracki, M.E. and Speich, S. and Stemmann, L. and Sunagawa, S. and Weissenbach, J. and Wincker, P. and Karsenti, E.
Science 348 (6237): 1261605. 22 May 2015

Photoswitchable fatty acids enable optical control of TRPV1.
Frank, J.A. and Moroni, M. and Moshourab, R. and Sumser, M. and Lewin, G.R. and Trauner, D.
Nature Communications 6 : 7118. 21 May 2015

Single-cell transcriptomics enters the age of mass production.
Junker, J.P. and van Oudenaarden, A.
Molecular Cell 58 (4): 563-564. 21 May 2015

Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.
Mino, T. and Murakawa, Y. and Fukao, A. and Vandenbon, A. and Wessels, H.H. and Ori, D. and Uehata, T. and Tartey, S. and Akira, S. and Suzuki, Y. and Vinuesa, C.G. and Ohler, U. and Standley, D.M. and Landthaler, M. and Fujiwara, T. and Takeuchi, O.
Cell 161 (5): 1058-1073. 21 May 2015

Computational eco-systems biology in Tara Oceans: translating data into knowledge.
Sunagawa, S. and Karsenti, E. and Bowler, C. and Bork, P.
Molecular Systems Biology 11 (5): 809. 21 May 2015

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Hoffmann, C.J. and Harms, U. and Rex, A. and Szulzewsky, F. and Wolf, S.A. and Grittner, U. and Lättig-Tünnemann, G. and Sendtner, M. and Kettenmann, H. and Dirnagl, U. and Endres, M. and Harms, C.
Circulation 131 (20): 1772-1782. 19 May 2015

eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.
Huang, J. and Chen, J. and Esparza, J. and Ding, J. and Elder, J.T. and Abecasis, G.R. and Lee, Y.A. and Lathrop, G.M. and Moffatt, M.F. and Cookson, W.O.C. and Liang, L.
Nature Communications 6 : 6821. 8 May 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. and Weber, T. and Wefers, B. and Wurst, W. and Sander, S. and Rajewsky, K. and Kühn, R.
Nature Biotechnology 33 (5): 543-548. May 2015

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M. and Bounab, Y. and Strempel, N. and Klockmeier, K. and Yigit, S. and Friedrich, R.P. and Chaurasia, G. and Li, S. and Hesse, F. and Riechers, S.P. and Russ, J. and Nicoletti, C. and Boeddrich, A. and Wiglenda, T. and Haenig, C. and Schnoegl, S. and Fournier, D. and Graham, R.K. and Hayden, M.R. and Sigrist, S. and Bates, G.P. and Priller, J. and Andrade-Navarro, M.A. and Futschik, M.E. and Wanker, E.E.
Genome Research 25 (5): 701-713. May 2015

The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.
Ullrich, K. and Blumenthal-Barby, F. and Lamprecht, B. and Koechert, K. and Lenze, D. and Hummel, M. and Mathas, S. and Doerken, B. and Janz, M.
Leukemia 29 (5): 1213-1218. May 2015

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv, Y. and Shomer, I. and Cohen-Kaplan, V. and Snijder, B. and Superti-Furga, G. and Gonen, H. and Sommer, T. and Ziv, T. and Admon, A. and Naroditsky, I. and Jbara, M. and Brik, A. and Pikarsky, E. and Kwon, Y.T. and Doweck, I. and Ciechanover, A.
Cell 161 (2): 333-347. 9 April 2015

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S. and Bruning, U. and Missiaen, R. and Queiroz, K.C.S. and Borgers, G. and Elia, I. and Zecchin, A. and Cantelmo, A.R. and Christen, S. and Goveia, J. and Heggermont, W. and Goddé, L. and Vinckier, S. and Van Veldhoven, P.P. and Eelen, G. and Schoonjans, L. and Gerhardt, H. and Dewerchin, M. and Baes, M. and De Bock, K. and Ghesquière, B. and Lunt, S.Y. and Fendt, S.M. and Carmeliet, P.
Nature 520 (7546): 192-197. 9 April 2015

Temporal and technical variability of human gut metagenomes.
Voigt, A.Y. and Costea, P.I. and Kultima, J.R. and Li, S.S. and Zeller, G. and Sunagawa, S. and Bork, P.
Genome Biology 16 (1): 73. 8 April 2015

A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
Aleksandrova, K. and Chuang, S.C. and Boeing, H. and Zuo, H. and Tell, G.S. and Pischon, T. and Jenab, M. and Bueno-de-Mesquita, B. and Vollset, S.E. and Midttun, Ø. and Ueland, P.M. and Fedirko, V. and Johansson, M. and Weiderpass, E. and Severi, G. and Racine, A. and Boutron-Ruault, M.C. and Kaaks, R. and Kühn, T. and Tjønneland, A. and Overvad, K. and Quirós, J.R. and Jakszyn, P. and Sánchez, M.J. and Dorronsoro, M. and Chirlaque, M.D. and Ardanaz, E. and Khaw, K.T. and Wareham, N.J. and Travis, R.C. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Palli, D. and Sieri, S. and Tumino, R. and Panico, S. and May, A.M. and Palmqvist, R. and Ljuslinder, I. and Kong, S.Y.J. and Freisling, H. and Gunter, M.J. and Lu, Y. and Cross, A.J. and Riboli, E. and Vineis, P.
Journal of the National Cancer Institute 107 (4): djv010. April 2015

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito, H. and Shiwaku, H. and Yoshida, C. and Homma, H. and Luo, H. and Chen, X. and Fujita, K. and Musante, L. and Fischer, U. and Frints, S.G.M. and Romano, C. and Ikeuchi, Y. and Shimamura, T. and Imoto, S. and Miyano, S. and Muramatsu, S.I. and Kawauchi, T. and Hoshino, M. and Sudol, M. and Arumughan, A. and Wanker, E.E. and Rich, T. and Schwartz, C. and Matsuzaki, F. and Bonni, A. and Kalscheuer, V.M. and Okazawa, H.
Molecular Psychiatry 20 (4): 459-471. April 2015

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M. and Leitão, C. and Leisegang, M. and Chen, X. and Gavvovidis, I. and van der Bruggen, P. and Uckert, W. and Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33 (4): 402-407. April 2015

Three-dimensional genome architecture: players and mechanisms.
Pombo, A. and Dillon, N.
Nature Reviews Molecular Cell Biology 16 (4): 245-257. April 2015

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
You, X. and Vlatkovic, I. and Babic, A. and Will, T. and Epstein, I. and Tushev, G. and Akbalik, G. and Wang, M. and Glock, C. and Quedenau, C. and Wang, X. and Hou, J. and Liu, H. and Sun, W. and Sambandan, S. and Chen, T. and Schuman, E.M. and Chen, W.
Nature Neuroscience 18 (4): 603-610. April 2015

Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.
Jantsch, J. and Schatz, V. and Friedrich, D. and Schröder, A. and Kopp, C. and Siegert, I. and Maronna, A. and Wendelborn, D. and Linz, P. and Binger, K.J. and Gebhardt, M. and Heinig, M. and Neubert, P. and Fischer, F. and Teufel, S. and David, J.P. and Neufert, C. and Cavallaro, A. and Rakova, N. and Küper, C. and Beck, F.X. and Neuhofer, W. and Muller, D.N. and Schuler, G. and Uder, M. and Bogdan, C. and Luft, F.C. and Titze, J.
Cell Metabolism 21 (3): 493-501. 3 March 2015

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.
Moussaieff, A. and Rouleau, M. and Kitsberg, D. and Cohen, M. and Levy, G. and Barasch, D. and Nemirovski, A. and Shen-Orr, S. and Laevsky, I. and Amit, M. and Bomze, D. and Elena-Herrmann, B. and Scherf, T. and Nissim-Rafinia, M. and Kempa, S. and Itskovitz-Eldor, J. and Meshorer, E. and Aberdam, D. and Nahmias, Y.
Cell Metabolism 21 (3): 392-402. 3 March 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner, E. and Daub, C.O. and Vitting-Seerup, K. and Andersson, R. and Lilje, B. and Drabløs, F. and Lennartsson, A. and Rönnerblad, M. and Hrydziuszko, O. and Vitezic, M. and Freeman, T.C. and Alhendi, A. and Arner, P. and Axton, R. and Baillie, J.K. and Beckhouse, A. and Bodega, B. and Briggs, J. and Brombacher, F. and Davis, M. and Detmar, M. and Ehrlund, A. and Endoh, M. and Eslami, A. and Fagiolini, M. and Fairbairn, L. and Faulkner, G.J. and Ferrai, C. and Fisher, M.E. and Forrester, L. and Goldowitz, D. and Guler, R. and Ha, T. and Hara, M. and Herlyn, M. and Ikawa, T. and Kai, C. and Kawamoto, H. and Khachigian, L. and Klinken, P.S. and Kojima, S. and Koseki, H. and Klein, S. and Mejhert, N. and Miyaguchi, K. and Mizuno, Y. and Morimoto, M. and Morris, K.J. and Mummery, C. and Nakachi, Y. and Ogishima, S. and Okada-Hatakeyama, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D. and Passier, R. and Patrikakis, M. and Pombo, A. and Qin, X.Y. and Roy, S. and Sato, H. and Savvi, S. and Saxena, A. and Schwegmann, A. and Sugiyama, D. and Swoboda, R. and Tanaka, H. and Tomoiu, A. and Winteringham, L.N. and Wolvetang, E. and Yanagi-Mizuochi, C. and Yoneda, M. and Zabierowski, S. and Zhang, P. and Abugessaisa, I. and Bertin, N. and Diehl, A.D. and Fukuda, S. and Furuno, M. and Harshbarger, J. and Hasegawa, A. and Hori, F. and Ishikawa-Kato, S. and Ishizu, Y. and Itoh, M. and Kawashima, T. and Kojima, M. and Kondo, N. and Lizio, M. and Meehan, T.F. and Mungall, C.J. and Murata, M. and Nishiyori-Sueki, H. and Sahin, S. and Sato-Nagao, S. and Severin, J. and de Hoon, M.J. and Kawai, J. and Kasukawa, T. and Lassmann, T. and Suzuki, H. and Kawaji, H. and Summers, K.M. and Wells, C. and Hume, D.A. and Forrest, A.R.R. and Sandelin, A. and Carninci, P. and Hayashizaki, Y.
Science 347 (6225): 1010-1014. 27 February 2015

In vivo reprogramming for tissue repair.
Heinrichs, C. and Spagnoli, F.M. and Berninger, B.
Nature Cell Biology 17 (3): 204-211. 27 February 2015

Human promoters are intrinsically directional.
Duttke, S.H.C. and Lacadie, S.A. and Ibrahim, M.M. and Glass, C.K. and Corcoran, D.L. and Benner, C. and Heinz, S. and Kadonaga, J.T. and Ohler, U.
Molecular Cell 57 (4): 674-684. 19 February 2015

GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C. and Moroni, M. and Lima, W.C. and Wende, H. and Kirchner, M. and Adelfinger, L. and Schrenk-Siemens, K. and Tappe-Theodor, A. and Wetzel, C. and Kuich, P.H. and Gassmann, M. and Roggenkamp, D. and Bettler, B. and Lewin, G.R. and Selbach, M. and Siemens, J.
Cell 160 (4): 759-770. 12 February 2015

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P. and Korotkova, T. and Heidenreich, M. and Maier, N. and Schuetze, S. and Kobler, O. and Zuschratter, W. and Schmitz, D. and Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6 : 6254. 4 February 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T. and Hendrix, S. and Boato, F. and Smirnov, I. and Zheng, J. and Lukens, J.R. and Gadani, S. and Hechler, D. and Gölz, G. and Rosenberger, K. and Kammertöns, T. and Vogt, J. and Vogelaar, C. and Siffrin, V. and Radjavi, A. and Fernandez-Castaneda, A. and Gaultier, A. and Gold, R. and Kanneganti, T.D. and Nitsch, R. and Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

Competition between target sites of regulators shapes post-transcriptional gene regulation.
Jens, M. and Rajewsky, N.
Nature Reviews Genetics 16 (2): 113-126. February 2015

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.
Lluch-Senar, M. and Delgado, J. and Chen, W.-H. and Llorens-Rico, V. and O'Reilly, F.J. and Wodke, J.A.H. and Unal, E.B. and Yus, E. and Martinez, S. and Nichols, R.J. and Ferrar, T. and Vivancos, A. and Schmeisky, A. and Stuelke, J. and van Noort, V. and Gavin, A.-C. and Bork, P. and Serrano, L.
Molecular Systems Biology 11 (1): 780. 21 January 2015

Monocytes compensate Kupffer cell loss during bacterial infection.
Molawi, K. and Sieweke, M.H.
Immunity 42 (1): 10-12. 20 January 2015

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M. and Ware, J.S. and Herman, D.S. and Schafer, S. and Baksi, J. and Bick, A.G. and Buchan, R.J. and Walsh, R. and John, S. and Wilkinson, S. and Mazzarotto, F. and Felkin, L.E. and Gong, S. and MacArthur, J.A.L. and Cunningham, F. and Flannick, J. and Gabriel, S.B. and Altshuler, D.M. and Macdonald, P.S. and Heinig, M. and Keogh, A.M. and Hayward, C.S. and Banner, N.R. and Pennell, D.J. and O'Regan, D.P. and San, T.R. and de Marvao, A. and Dawes, T.J.W. and Gulati, A. and Birks, E.J. and Yacoub, M.H. and Radke, M. and Gotthardt, M. and Wilson, J.G. and O'Donnell, C.J. and Prasad, S.K. and Barton, P.J.R. and Fatkin, D. and Hubner, N. and Seidman, J.G. and Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
Baurecht, H. and Hotze, M. and Brand, S. and Büning, C. and Cormican, P. and Corvin, A. and Ellinghaus, D. and Ellinghaus, E. and Esparza-Gordillo, J. and Fölster-Holst, R. and Franke, A. and Gieger, C. and Hubner, N. and Illig, T. and Irvine, A.D. and Kabesch, M. and Lee, Y.A.E. and Lieb, W. and Marenholz, I. and McLean, W.H.I. and Morris, D.W. and Mrowietz, U. and Nair, R. and Nöthen, M.M. and Novak, N. and O'Regan, G.M. and Schreiber, S. and Smith, C. and Strauch, K. and Stuart, P.E. and Trembath, R. and Tsoi, L.C. and Weichenthal, M. and Barker, J. and Elder, J.T. and Weidinger, S. and Cordell, H.J. and Brown, S.J.
American Journal of Human Genetics 96 (1): 104-120. 8 January 2015

Waddington's Valleys and Captain Cook's Islands.
Sieweke, M.H.
Cell Stem Cell 16 (1): 7-8. 8 January 2015

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C. and Kind, B. and Reijns, M.A.M. and Berndt, N. and Martinez-Bueno, M. and Wolf, C. and Tüngler, V. and Chara, O. and Lee, Y.A. and Hübner, N. and Bicknell, L. and Blum, S. and Krug, C. and Schmidt, F. and Kretschmer, S. and Koss, S. and Astell, K.R. and Ramantani, G. and Bauerfeind, A. and Morris, D.L. and Cunninghame Graham, D.S. and Bubeck, D. and Leitch, A. and Ralston, S.H. and Blackburn, E.A. and Gahr, M. and Witte, T. and Vyse, T.J. and Melchers, I. and Mangold, E. and Nöthen, M.M. and Aringer, M. and Kuhn, A. and Lüthke, K. and Unger, L. and Bley, A. and Lorenzi, A. and Isaacs, J.D. and Alexopoulou, D. and Conrad, K. and Dahl, A. and Roers, A. and Alarcon-Riquelme, M.E. and Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125 (1): 413-424. 2 January 2015

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A. and Grau, M. and Erdmann, T. and Merkel, O. and Sobhiafshar, U. and Anagnostopoulos, I. and Hummel, M. and Siegert, A. and Hayford, C. and Madle, H. and Wollert-Wulf, B. and Fichtner, I. and Dörken, B. and Dirnhofer, S. and Mathas, S. and Janz, M. and Emre, N.C.T. and Rosenwald, A. and Ott, G. and Lenz, P. and Tzankov, A. and Lenz, G.
Blood 125 (1): 124-132. 1 January 2015

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K. and Wende, H. and Prato, V. and Song, K. and Rostock, C. and Loewer, A. and Utikal, J. and Lewin, G.R. and Lechner, S.G. and Siemens, J.
Nature Neuroscience 18 (1): 10-16. January 2015


Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A. and Murakawa, Y. and Rosenbaum, E. and Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade, S.S. and Woo, S.H. and Dubin, A.E. and Moshourab, R.A. and Wetzel, C. and Petrus, M. and Mathur, J. and Bégay, V. and Coste, B. and Mainquist, J. and Wilson, A.J. and Francisco, A.G. and Reddy, K. and Qiu, Z. and Wood, J.N. and Lewin, G.R. and Patapoutian, A.
Nature 516 (7529): 121-125. 4 December 2014

Paternal diet defines offspring chromatin state and intergenerational obesity.
Öst, A. and Lempradl, A. and Casas, E. and Weigert, M. and Tiko, T. and Deniz, M. and Pantano, L. and Boenisch, U. and Itskov, P.M. and Stoeckius, M. and Ruf, M. and Rajewsky, N. and Reuter, G. and Iovino, N. and Ribeiro, C. and Alenius, M. and Heyne, S. and Vavouri, T. and Pospisilik, J.A.
Cell 159 (6): 1352-1364. 4 December 2014

Cortical fosGFP expression reveals broad receptive field excitatory neurons targeted by POm.
Jouhanneau, J.S. and Ferrarese, L. and Estebanez, L. and Audette, N.J. and Brecht, M. and Barth, AL. and Poulet, J.F.A.
Neuron 84 (5): 1065-1078. 3 December 2014

Rsp5/Nedd4 clears cells of heat-damaged proteins.
Sommer, T. and Weber, A. and Jarosch, E.
Nature Cell Biology 16 (12): 1130-1132. 1 December 2014

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W. and Theillet, F.X. and Katzer, A. and Finzel, A. and Mishall, K.M. and Powell, A.T. and Wu, H. and Manieri, W. and Dieterich, C. and Selenko, P. and Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10 (12): 1000-1002. December 2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K. and Gätjen, M. and Grau, M. and Stache, V. and Anagnostopoulos, I. and Gerlach, K. and Niesner, R.A. and Cseresnyes, Z. and Hauser, A.E. and Lenz, P. and Hehlgans, T. and Brink, R. and Westermann, J. and Dörken, B. and Lipp, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Mixed messages: re-initiation factors regulate translation of animal mRNAs.
Obermayer, B. and Rajewsky, N.
Cell Research 24 (12): 1383-1384. December 2014

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes.
Schubert, J. and Siekierska, A. and Langlois, M. and May, P. and Huneau, C. and Becker, F. and Muhle, H. and Suls, A. and Lemke, J.R. and de Kovel, C.G.F. and Thiele, H. and Konrad, K. and Kawalia, A. and Toliat, M.R. and Sander, T. and Rueschendorf, F. and Caliebe, A. and Nagel, I. and Kohl, B. and Kecskes, A. and Jacmin, M. and Hardies, K. and Weckhuysen, S. and Riesch, E. and Dorn, T. and Brilstra, E.H. and Baulac, S. and Moller, R.S. and Hjalgrim, H. and Koeleman, B.P.C. and Jurkat-Rott, K. and Lehman-Horn, F. and Roach, J.C. and Glusman, G. and Hood, L. and Galas, D.J. and Martin, B. and de Witte, P.A.M. and Biskup, S. and De Jonghe, P. and Helbig, I. and Balling, R. and Nuernberg, P. and Crawford, A.D. and Esguerra, C.V. and Weber, Y.G. and Lerche, H.
Nature Genetics 46 (12): 1327-1332. December 2014

Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller, G. and Tap, J. and Voigt, A.Y. and Sunagawa, S. and Kultima, J.R. and Costea, P.I. and Amiot, A. and Boehm, J. and Brunetti, F. and Habermann, N. and Hercog, R. and Koch, M. and Luciani, A. and Mende, D.R. and Schneider, M.A. and Schrotz-King, P. and Tournigand, C. and Tran Van Nhieu, J. and Yamada, T. and Zimmermann, J. and Benes, V. and Kloor, M. and Ulrich, C.M. and von Knebel Doeberitz, M. and Sobhani, I. and Bork, P.
Molecular Systems Biology 10 (11): 766. 28 November 2014

A variety of dicer substrates in human and C. elegans.
Rybak-Wolf, A. and Jens, M. and Murakawa, Y. and Herzog, M. and Landthaler, M. and Rajewsky, N.
Cell 159 (5): 1153-1167. 20 November 2014

Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E. and Rother, M. and Kerr, M.C. and Al-Zeer, M.A. and Abu-Lubad, M. and Kessler, M. and Brinkmann, V. and Loewer, A. and Meyer, T.F.
Nature Communications 5 : 5201. 13 November 2014

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.
Cui, Y. and Niziolek, P.J. and MacDonald, B.T. and Alenina, N. and Matthes, S. and Jacobsen, C.M. and Conlon, R.A. and Brommage, R. and Powell, D.R. and He, X. and Bader, M. and Williams, B.O. and Warman, M.L. and Robling, A.G.
Nature Medicine 20 (11): 1229-1230. 6 November 2014

Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Hoepken, U.E.
Blood 124 (19): 2897-2898. 6 November 2014

Tissue macrophage identity and self-renewal.
Gentek, R. and Molawi, K. and Sieweke, M.H.
Immunological Reviews 262 (1): 56-73. November 2014

A somatosensory circuit for cooling perception in mice.
Milenkovic, N. and Zhao, W.J. and Walcher, J. and Albert, T. and Siemens, J. and Lewin, G.R. and Poulet, J.F.A.
Nature Neuroscience 17 (11): 1560-1566. November 2014

Keeping an eye on cortical States.
Poulet, J.F.A.
Neuron 84 (2): 246-248. 22 October 2014

Progressive replacement of embryo-derived cardiac macrophages with age.
Molawi, K. and Wolf, Y. and Kandalla, P.K. and Favret, J. and Hagemeyer, N. and Frenzel, K. and Pinto, A.R. and Klapproth, K. and Henri, S. and Malissen, B. and Rodewald, H.R. and Rosenthal, N.A. and Bajenoff, M. and Prinz, M. and Jung, S. and Sieweke, M.H.
Journal of Experimental Medicine 211 (11): 2151-2158. 20 October 2014

Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D. and Melick, C.H. and Clements, W.K. and Stachura, D.L. and Distel, M. and Panáková, D. and MacRae, C. and Mork, L.A. and Crump, J.G. and Traver, D.
EMBO Journal 33 (20): 2363-2373. 16 October 2014

Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Loos, M. and Mueller, T. and Gouwenberg, Y. and Wijnands, R. and van der Loo, R.J. and Birchmeier, C. and Smit, A.B. and Spijker, S.
Biological Psychiatry 76 (8): 648-655. 15 October 2014

circRNA biogenesis competes with pre-mRNA splicing.
Ashwal-Fluss, R. and Meyer, M. and Pamudurti, N.R. and Ivanov, A. and Bartok, O. and Hanan, M. and Evantal, N. and Memczak, S. and Rajewsky, N. and Kadener, S.
Molecular Cell 56 (1): 55-66. 2 October 2014

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. and Escobar, H. and Gloy, S. and Kufeld, M. and Zacher, J. and Spuler, A. and Birchmeier, C. and Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

Mas and its related G protein-coupled receptors, Mrgprs.
Bader, M. and Alenina, N. and Andrade-Navarro, M.A. and Santos, R.A.
Pharmacological Reviews 66 (4): 1080-1105. October 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A. and Gätjen, M. and Gerlach, K. and Scholz, F. and Mensen, A. and Gloger, M. and Heinig, K. and Lamprecht, B. and Mathas, S. and Bégay, V. and Leutz, A. and Lipp, M. and Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvák, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Nature 513 (7517): 195-201. 11 September 2014

Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.
Zemojtel, T. and Koehler, S. and Mackenroth, L. and Jaeger, M. and Hecht, J. and Krawitz, P. and Graul-Neumann, L. and Doelken, S. and Ehmke, N. and Spielmann, M. and Oien, N.C. and Schweiger, M.R. and Krueger, U. and Frommer, G. and Fischer, B. and Kornak, U. and Floettmann, R. and Ardeshirdavani, A. and Moreau, Y. and Lewis, S.E. and Haendel, M. and Smedley, D. and Horn, D. and Mundlos, S. and Robinson, P.N.
Science Translational Medicine 6 (252): 252ra123. 3 September 2014

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer.
Aleksandrova, K. and Boeing, H. and Nöthlings, U. and Jenab, M. and Fedirko, V. and Kaaks, R. and Lukanova, A. and Trichopoulou, A. and Trichopoulos, D. and Boffetta, P. and Trepo, E. and Westhpal, S. and Duarte-Salles, T. and Stepien, M. and Overvad, K. and Tjønneland, A. and Halkjaer, J. and Boutron-Ruault, M.C. and Dossus, L. and Racine, A. and Lagiou, P. and Bamia, C. and Benetou, V. and Agnoli, C. and Palli, D. and Panico, S. and Tumino, R. and Vineis, P. and Bueno-de-Mesquita, B. and Peeters, P.H. and Gram, I.T. and Lund, E. and Weiderpass, E. and Quirós, J.R. and Agudo, A. and Sánchez, M.J. and Gavrila, D. and Barricarte, A. and Dorronsoro, M. and Ohlsson, B. and Lindkvist, B. and Johansson, A. and Sund, M. and Khaw, K.T. and Wareham, N. and Travis, R.C. and Riboli, E. and Pischon, T.
Hepatology 60 (3): 858-871. September 2014

CNS macrophages and peripheral myeloid cells in brain tumours.
Glass, R. and Synowitz, M.
Acta Neuropathologica 128 (3): 347-362. September 2014

Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D. and Waterhouse, P.D. and Shelton, D. and Shao, Y.W. and Watling, C.M. and Tang, Q.L. and Harris, I.S. and Dickson, B.C. and Tharmapalan, P. and Sandve, G.K. and Zhang, X. and Bailey, S.D. and Berman, H. and Wunder, J.S. and Izsvák, Z. and Lupien, M. and Mak, T.W. and Khokha, R.
Nature Genetics 46 (9): 964-972. September 2014

Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.
Stoeckius, M. and Grün, D. and Kirchner, M. and Ayoub, S. and Torti, F. and Piano, F. and Herzog, M. and Selbach, M. and Rajewsky, N.
EMBO Journal 33 (16): 1751-1766. 18 August 2014

Paternal RNA contributions in the Caenorhabditis elegans zygote.
Stoeckius, M. and Grün, D. and Rajewsky, N.
EMBO Journal 33 (16): 1740-1750. 18 August 2014

Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial.
Oettle, H. and Riess, H. and Stieler, J.M. and Heil, G. and Schwaner, I. and Seraphin, J. and Goerner, M. and Moelle, M. and Greten, T.F. and Lakner, V. and Bischoff, S. and Sinn, M. and Doerken, B. and Pelzer, U.
Journal of Clinical Oncology 32 (23): 2423-2429. 10 August 2014

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Libri, V. and Yandim, C. and Athanasopoulos, S. and Loyse, N. and Natisvili, T. and Law, P.P. and Chan, P.K. and Mohammad, T. and Mauri, M. and Tam, K.T. and Leiper, J. and Piper, S. and Ramesh, A. and Parkinson, M.H. and Huson, L. and Giunti, P. and Festenstein, R.
Lancet 384 (9942): 504-513. 9 August 2014

Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.
Mensen, A. and Jöhrens, K. and Anagnostopoulos, I. and Demski, S. and Oey, M. and Stroux, A. and Hemmati, P. and Westermann, J. and Blau, O. and Wittenbecher, F. and Movassaghi, K. and Szyska, M. and Thomas, S. and Dörken, B. and Scheibenbogen, C. and Arnold, R. and Na, I.K.
Blood 124 (6): 963-972. 7 August 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal, M. and Zheng, Y. and Hultin, S. and Audebert, S. and van Harn, T. and Johnsson, P. and Lenander, C. and Fritz, N. and Mieth, C. and Corcoran, M. and Lembo, F. and Hallstroem, M. and Hartman, J. and Mazure, N.M. and Weide, T. and Grander, D. and Borg, J.P. and Uhlen, P. and Holmgren, L.
Nature Communications 5 : 4557. 1 August 2014

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G. and Kopplin, K. and Blasig, R. and Stuiver, M. and Koning, N. and Goverse, G. and van der Pol, S.M.A. and van het Hof, B. and Gollasch, M. and Drexhage, J.A.R. and Reijerkerk, A. and Meij, I.C. and Mebius, R. and Willnow, T.E. and Müller, D. and Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128 (2): 267-277. August 2014

An integrated catalog of reference genes in the human gut microbiome.
Li, J. and Jia, H. and Cai, X. and Zhong, H. and Feng, Q. and Sunagawa, S. and Arumugam, M. and Kultima, J.R. and Prifti, E. and Nielsen, T. and Juncker, A.S. and Manichanh, C. and Chen, B. and Zhang, W. and Levenez, F. and Wang, J. and Xu, X. and Xiao, L. and Liang, S. and Zhang, D. and Zhang, Z. and Chen, W. and Zhao, H. and Al-Aama, J.Y. and Edris, S. and Yang, H. and Wang, J. and Hansen, T. and Nielsen, H.B. and Brunak, S. and Kristiansen, K. and Guarner, F. and Pedersen, O. and Dore, J. and Ehrlich, S.D. and Bork, P. and Wang, J.
Nature Biotechnology 32 (8): 834-841. August 2014

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
Nielsen, H.B. and Almeida, M. and Juncker, A.S. and Rasmussen, S. and Li, J. and Sunagawa, S. and Plichta, D.R. and Gautier, L. and Pedersen, A.G. and Le Chatelier, E. and Pelletier, E. and Bonde, I. and Nielsen, T. and Manichanh, C. and Arumugam, M. and Batto, J.M. and Quintanilha Dos Santos, M.B. and Blom, N. and Borruel, N. and Burgdorf, K.S. and Boumezbeur, F. and Casellas, F. and Dore, J. and Dworzynski, P. and Guarner, F. and Hansen, T. and Hildebrand, F. and Kaas, R.S. and Kennedy, S. and Kristiansen, K. and Kultima, J.R. and Leonard, P. and Levenez, F. and Lund, O. and Moumen, B. and Le Paslier, D. and Pons, N. and Pedersen, O. and Prifti, E. and Qin, J. and Raes, J. and Sorensen, S. and Tap, J. and Tims, S. and Ussery, D.W. and Yamada, T. and Renault, P. and Sicheritz-Ponten, T. and Bork, P. and Wang, J. and Brunak, S. and Ehrlich, S.D.
Nature Biotechnology 32 (8): 822-828. August 2014

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
Motamedi, F.J. and Badro, D.A. and Clarkson, M. and Rita Lecca, M. and Bradford, S.T. and Buske, F.A. and Saar, K. and Hübner, N. and Bräendli, A.W. and Schedl, A.
Nature Communications 5 : 4444. 17 July 2014

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly.
Belz, K. and Schoeneberger, H. and Wehner, S. and Weigert, A. and Boenig, H. and Klingebiel, T. and Fichtner, I. and Fulda, S.
Blood 124 (2): 240-250. 10 July 2014

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J. and Kassmann, M. and Szijártó, I.A. and Hercule, H.C. and Tano, J.Y. and Weinert, S. and Heidenreich, M. and Pathan, A.R. and Anistan, Y.M. and Alenina, N. and Rusch, N.J. and Bader, M. and Jentsch, T.J. and Gollasch, M.
Circulation Research 115 (2): 263-272. 7 July 2014

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V. and Furlan, A. and Shahidi, M.K. and Giovenco, M. and Kaukua, N. and Konstantinidou, C. and Pachnis, V. and Memic, F. and Marklund, U. and Müller, T. and Birchmeier, C. and Fried, K. and Ernfors, P. and Adameyko, I.
Science 345 (6192): 82-87. 4 July 2014

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M. and Agarwal, N. and Stösser, S. and Bali, K.K. and Karaulanov, E. and Kamble, R. and Pospisilova, B. and Kurejova, M. and Birchmeier, W. and Niehrs, C. and Heppenstall, P. and Kuner, R.
Neuron 83 (1): 104-121. 2 July 2014

α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N. and Kulkarni, R. and Werth, M. and Schmidt-Ott, K.M. and Forster, C. and Deng, R. and Zhang, Q. and Singer, E. and Klose, A.D. and Shen, T.H. and Francis, K.P. and Ray, S. and Vijayakumar, S. and Seward, S. and Bovino, M.E. and Xu, K. and Takabe, Y. and Amaral, F.E. and Mohan, S. and Wax, R. and Corbin, K. and Sanna-Cherchi, S. and Mori, K. and Johnson, L. and Nickolas, T. and D’Agati, V. and Lin, C.S. and Qiu, A. and Al-Awqati, Q. and Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124 (7): 2963-2976. 1 July 2014

Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.
Grosswendt, S. and Filipchyk, A. and Manzano, M. and Klironomos, F. and Schilling, M. and Herzog, M. and Gottwein, E. and Rajewsky, N.
Molecular Cell 54 (6): 1042-1054. 19 June 2014

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel, R. and Trenkwalder, T. and Petersen, B. and Husada, W. and Gesenhues, F. and Lee, S. and Hannappel, E. and Bock-Marquette, I. and Theisen, D. and Leitner, L. and Boekstegers, P. and Cierniewski, C. and Mueller, O.J. and Le Noble, F. and Adams, R.H. and Weinl, C. and Nordheim, A. and Reichart, B. and Weber, C. and Olson, E. and Posern, G. and Deindl, E. and Niemann, H. and Kupatt, C.
Nature Communications 5 : 3970. 9 June 2014

Stem cell epigenetics: looking forward.
Benitah, S.A. and Bracken, A. and Dou, Y. and Huangfu, D. and Ivanova, N. and Koseki, H. and Laurent, L. and Lim, D.A. and Meshorer, E. and Pombo, A. and Sander, M. and Xu, G.L.
Cell Stem Cell 14 (6): 706-709. 5 June 2014

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.
Glerup, S. and Olsen, D. and Vaegter, C.B. and Gustafsen, C. and Sjoegaard, S.S. and Hermey, G. and Kjolby, M. and Molgaard, S. and Ulrichsen, M. and Boggild, S. and Skeldal, S. and Fjorback, A.N. and Nyengaard, J.R. and Jacobsen, J. and Bender, D. and Bjarkam, C.R. and Sørensen, E.S. and Füchtbauer, E.M. and Eichele, G. and Madsen, P. and Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Neuron 82 (5): 1074-87. 4 June 2014

Natural variation of histone modification and its impact on gene expression in the rat genome.
Rintisch, C. and Heinig, M. and Bauerfeind, A. and Schafer, S. and Mieth, C. and Patone, G. and Hummel, O. and Chen, W. and Cook, S. and Cuppen, E. and Colomé-Tatché, M. and Johannes, F. and Jansen, R.C. and Neil, H. and Werner, M. and Pravenec, M. and Vingron, M. and Hubner, N.
Genome Research 24 (6): 942-953. June 2014

MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H. and Schueler, M. and Munschauer, M. and Mastrobuoni, G. and Chen, W. and Kempa, S. and Dieterich, C. and Landthaler, M.
Molecular Cell 54 (4): 573-585. 22 May 2014

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K. and Ullrich, F. and Muench, J. and Lazarow, K. and Lutter, D. and Mah, N. and Andrade-Navarro, M.A. and von Kries, J.P. and Stauber, T. and Jentsch, T.J.
Science 344 (6184): 634-638. 9 May 2014

Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.
Bazzini, A.A. and Johnstone, T.G. and Christiano, R. and Mackowiak, S.D. and Obermayer, B. and Fleming, E.S. and Vejnar, C.E. and Lee, M.T. and Rajewsky, N. and Walther, T.C. and Giraldez, A.J.
EMBO Journal 33 (9): 981-993. 2 May 2014

Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A.
Auer, F. and Rueschendorf, F. and Gombert, M. and Husemann, P. and Ginzel, S. and Izraeli, S. and Harit, M. and Weintraub, M. and Weinstein, O.Y. and Lerer, I. and Stepensky, P. and Borkhardt, A. and Hauer, J.
Leukemia 28 (5): 1136-1138. May 2014

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Aksoy, I. and Giudice, V. and Delahaye, E. and Wianny, F. and Aubry, M. and Mure, M. and Chen, J. and Jauch, R. and Bogu, G.K. and Nolden, T. and Himmelbauer, H. and Doss, M.X. and Sachinidis, A. and Schulz, H. and Hummel, O. and Martinelli, P. and Hübner, N. and Stanton, L.W. and Real, F.X. and Bourillot, P.Y. and Savatier, P.
Nature Communications 5 : 3719. 28 April 2014

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
Michalik, K.M. and You, X. and Manavski, Y. and Doddaballapur, A. and Zoernig, M. and Braun, T. and John, D. and Ponomareva, Y. and Chen, W. and Uchida, S. and Boon, R.A. and Dimmeler, S.
Circulation Research 114 (9): 1389-1397. 25 April 2014

Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole, K. and Herget, R. and Lapatsina, L. and Ngo, H.D. and Lewin, G.R.
Nature Communications 5 : 3520. 24 March 2014

Bone biology: vessels of rejuvenation.
Le Noble, F. and Le Noble, J.
Nature 507 (7492): 313-314. 20 March 2014

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Hoegg-Beiler, M.B. and Sirisi, S. and Orozco, I.J. and Ferrer, I. and Hohensee, S. and Auberson, M. and Goedde, K. and Vilches, C. and de Heredia, M.L. and Nunes, V. and Estévez, R. and Jentsch, T.J.
Nature Communications 5 : 3475. 19 March 2014

Hexosamine pathway metabolites enhance protein quality control and prolong life.
Denzel, M.S. and Storm, N.J. and Gutschmidt, A. and Baddi, R. and Hinze, Y. and Jarosch, E. and Sommer, T. and Hoppe, T. and Antebi, A.
Cell 156 (6): 1167-1178. 13 March 2014

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
Vaeth, M. and Mueller, G. and Stauss, D. and Dietz, L. and Klein-Hessling, S. and Serfling, E. and Lipp, M. and Berberich, I. and Berberich-Siebelt, F.
Journal of Experimental Medicine 211 (3): 545-561. 10 March 2014

Gene expression: degrade to derepress.
McShane, E. and Selbach, M.
EMBO Journal 33 (5): 407-408. 3 March 2014

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D. and Rocca, E. and Oonk, A.M.M. and Schulz, H. and Rohde, E. and Bednarsch, J. and Feenstra, I. and Pennings, R.J.E. and Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124 (3): 1214-1227. 3 March 2014

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.
Scholtens, S. and Postma, D.S. and Moffatt, M.F. and Panasevich, S. and Granell, R. and Henderson, A.J. and Melen, E. and Nyberg, F. and Pershagen, G. and Jarvis, D. and Ramasamy, A. and Wjst, M. and Svanes, C. and Bouzigon, E. and Demenais, F. and Kauffmann, F. and Siroux, V. and von Mutius, E. and Ege, M.J. and Braun-Fahrlaender, C. and Genuneit, J. and Brunekreef, B. and Smit, H.A. and Wijga, A.H. and Kerkhof, M. and Curjuric, I. and Imboden, M. and Thun, G.A. and Probst-Hensch, N. and Freidin, M.B. and Bragina, E.I. and Deev, I.A. and Puzyrev, V.P. and Daley, D. and Park, J. and Becker, A. and Chan-Yeung, M. and Kozyrskyj, A.L. and Pare, P. and Marenholz, I. and Lau, S. and Keil, T. and Lee, Y.A. and Kabesch, M. and Wijmenga, C. and Franke, L. and Nolte, I.M. and Vonk, J. and Kumar, A. and Farrall, M. and Cookson, W.O.C.M. and Strachan, D.P. and Koppelman, G.H. and Boezen, H.M.
Journal of Allergy and Clinical Immunology 133 (3): 885-888. March 2014

BAR domain scaffolds in dynamin-mediated membrane fission.
Daumke, O. and Roux, A. and Haucke, V.
Cell 156 (5): 882-892. 27 February 2014

Retrograde signaling causes excitement.
Schmitz, D. and Breustedt, J. and Gundlfinger, A.
Neuron 81 (4): 717-719. 19 February 2014

Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J. and Bezzina, C.R. and Freiberg, F. and Verkerk, A.O. and Adriaens, M.E. and Podliesna, S. and Chen, C. and Purfürst, B. and Spallek, B. and Koopmann, T.T. and Baczko, I. and Dos Remedios, C.G. and George, A.L. and Bishopric, N.H. and Lodder, E.M. and de Bakker, J.M.T. and Fischer, R. and Coronel, R. and Wilde, A.A.M. and Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63 (6): 549-559. 18 February 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S. and Takagi-Niidome, S. and Liao, F. and Carlo, A.S. and Schmidt, V. and Burgert, T. and Kitago, Y. and Füchtbauer, E.M. and Füchtbauer, A. and Holtzman, D.M. and Takagi, J. and Willnow, T.E.
Science Translational Medicine 6 (223): 223ra20. 12 February 2014

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C. and Seniuk, A. and Sokolov, M.V. and Huebner, A.K. and Klementowicz, A.E. and Szijártó, I.A. and Schleifenbaum, J. and Vitzthum, H. and Gollasch, M. and Ehmke, H. and Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124 (2): 675-686. 3 February 2014

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A. and Maggio, N. and Eller, J. and Caliskan, G. and Semtner, M. and Häussler, U. and Jüttner, R. and Dugladze, T. and Smolinsky, B. and Kowalczyk, S. and Chronowska, E. and Schwarz, G. and Rathjen, F.G. and Rechavi, G. and Haas, C.A. and Kulik, A. and Gloveli, T. and Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. and McShane, E. and Cheret, C. and Walcher, J. and Müller, T. and Wulf-Goldenberg, A. and Hoelper, S. and Garratt, A.N. and Krüger, M. and Rajewsky, K. and Meijer, D. and Birchmeier, W. and Lewin, G.R. and Selbach, M. and Birchmeier, C.
Genes & Development 28 (3): 290-303. 1 February 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M. and Munschauer, M. and Gregersen, L.H. and Finzel, A. and Loewer, A. and Chen, W. and Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

Global target mRNA specification and regulation by the RNA-binding protein ZFP36.
Mukherjee, N. and Jacobs, N.C. and Hafner, M. and Kennington, E.A. and Nusbaum, J.D. and Tuschl, T. and Blackshear, P.J. and Ohler, U.
Genome Biology 15 (1): R12. 8 January 2014

Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Tattikota, S.G. and Rathjen, T. and McAnulty, S.J. and Wessels, H.H. and Akerman, I. and van de Bunt, M. and Hausser, J. and Esguerra, J.L.S. and Musahl, A. and Pandey, A.K. and You, X. and Chen, W. and Herrera, P.L. and Johnson, P.R. and O'Carroll, D. and Eliasson, L. and Zavolan, M. and Gloyn, A.L. and Ferrer, J. and Shalom-Feuerstein, R. and Aberdam, D. and Poy, M.N.
Cell Metabolism 19 (1): 122-134. 7 January 2014

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.
Cochella, L. and Tursun, B. and Hsieh, Y.W. and Galindo, S. and Johnston, R.J. and Chuang, C.F. and Hobert, O.
Genes & Development 28 (1): 34-43. 1 January 2014

Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.
Kyrø, C and Olsen, A and Landberg, R and Skeie, G and Loft, S and Åman, P and Leenders, M and Dik, VK and Siersema, PD and Pischon, T. and Christensen, J and Overvad, K and Boutron-Ruault, MC and Fagherazzi, G and Cottet, V and Kühn, T and Chang-Claude, J and Boeing, H and Trichopoulou, A and Bamia, C and Trichopoulos, D and Palli, D and Krogh, V and Tumino, R and Vineis, P and Panico, S and Peeters, PH and Weiderpass, E and Bakken, T and Åsli, LA and Argüelles, M and Jakszyn, P and Sánchez, MJ and Amiano, P and Huerta, JM and Barricarte, A and Ljuslinder, I and Palmqvist, R and Khaw, KT and Wareham, N and Key, TJ and Travis, RC and Ferrari, P and Freisling, H and Jenab, M and Gunter, MJ and Murphy, N and Riboli, E and Tjønneland, A and Bueno-de-Mesquita, HB
Journal of the National Cancer Institute 106 (1): djt352. 1 January 2014

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α.
Brooke, M.A. and Longhurst, H.J. and Plagnol, V. and Kirkby, N.S. and Mitchell, J.A. and Rüschendorf, F. and Warner, T.D. and Kelsell, D.P. and MacDonald, T.T.
Gut 63 (1): 96-104. January 2014

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.
Mehnert, M. and Sommer, T. and Jarosch, E.
Nature Cell Biology 16 (1): 77-86. January 2014

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R. and Frick, M. and Romero, R. and Korn, J.M. and Kridel, R. and Chun Chan, F. and Meissner, B. and Bhang, H.E. and Ruddy, D. and Kauffmann, A. and Farsidjani, A. and Derti, A. and Rakiec, D. and Naylor, T. and Pfister, E. and Kovats, S. and Kim, S. and Dietze, K. and Doerken, B. and Steidl, C. and Tzankov, A. and Hummel, M. and Monahan, J. and Morrissey, M.P. and Fritsch, C. and Sellers, W.R. and Cooke, V.G. and Gascoyne, R.D. and Lenz, G. and Stegmeier, F.
Nature Medicine 20 (1): 87-92. January 2014


Evolution and functional cross-talk of protein post-translational modifications.
Beltrao, P. and Bork, P. and Krogan, N.J. and van Noort, V.
Molecular Systems Biology 9 : 714. 22 December 2013

Metagenomic species profiling using universal phylogenetic marker genes.
Sunagawa, S. and Mende, D.R. and Zeller, G. and Izquierdo-Carrasco, F. and Berger, S.A. and Kultima, J.R. and Coelho, L.P. and Arumugam, M. and Tap, J. and Nielsen, H.B. and Rasmussen, S. and Brunak, S. and Pedersen, O. and Guarner, F. and de Vos, W.M. and Wang, J. and Li, J. and Dore, J. and Ehrlich, S.D. and Stamatakis, A. and Bork, P.
Nature Methods 10 (12): 1196-1199. December 2013

Beyond stem cells: self-renewal of differentiated macrophages.
Sieweke, M.H. and Allen, J.E.
Science 342 (6161): 1242974. 22 November 2013

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G. and Milić, J and Eldahshan, A and Götz, F. and Zühlke, K. and Schillinger, C. and Kreuchwig, A. and Elkins, J.M. and Abdul Azeez, K.R.A. and Oder, A. and Moutty, M.C. and Masada, N. and Beerbaum, M. and Schlegel, B. and Niquet, S. and Schmieder, P. and Krause, G. and von Kries, J.P. and Cooper, D.M.F. and Knapp, S. and Rademann, J. and Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C. and Heemskerk, B. and Kvistborg, P. and Kluin, R.J.C. and Bolotin, D.A. and Chen, X. and Bresser, K. and Nieuwland, M. and Schotte, R. and Michels, S. and Gomez-Eerland, R. and Jahn, L. and Hombrink, P. and Legrand, N. and Shu, C.J. and Mamedov, I.Z. and Velds, A. and Blank, C.U. and Haanen, J.B.A.G. and Turchaninova, M.A. and Kerkhoven, R.M. and Spits, H. and Hadrup, S.R. and Heemskerk, M.H.M. and Blankenstein, T. and Chudakov, D.M. and Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19 (11): 1534-1541. November 2013

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M. and Landles, C. and Weiss, A. and Bradaia, A. and Seredenina, T. and Inuabasi, L. and Osborne, G.F. and Wadel, K. and Touller, C. and Butler, R. and Robertson, J. and Franklin, S.A. and Smith, D.L. and Park, L. and Marks, P.A. and Wanker, E.E. and Olson, E.N. and Luthi-Carter, R. and van der Putten, H. and Beaumont, V. and Bates, G.P.
PLoS Biology 11 (11): e1001717. November 2013

Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.
Nordlinger, B. and Sorbye, H. and Glimelius, B. and Poston, G.J. and Schlag, P.M. and Rougier, P. and Bechstein, W.O. and Primrose, J.N. and Walpole, E.T. and Finch-Jones, M. and Jaeck, D. and Mirza, D. and Parks, R.W. and Mauer, M. and Tanis, E. and Van Cutsem, E. and Scheithauer, W. and Gruenberger, T.
Lancet Oncology 14 (12): 1208-1215. November 2013

BMP signaling controls muscle mass.
Sartori, R. and Schirwis, E. and Blaauw, B. and Bortolanza, S. and Zhao, J. and Enzo, E. and Stantzou, A. and Mouisel, E. and Toniolo, L. and Ferry, A. and Stricker, S. and Goldberg, A.L. and Dupont, S. and Piccolo, S. and Amthor, H. and Sandri, M.
Nature Genetics 45 (11): 1309-1318. November 2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Saunders, S.P. and Goh, C.S.M. and Brown, S.J. and Palmer, C.N.A. and Porter, R.M. and Cole, C. and Campbell, L.E. and Gierlinski, M. and Barton, G.J. and Schneider, G. and Balmain, A. and Prescott, A.R. and Weidinger, S. and Baurecht, H. and Kabesch, M. and Gieger, C. and Lee, Y.A. and Tavendale, R. and Mukhopadhyay, S. and Turner, S.W. and Madhok, V.B. and Sullivan, F.M. and Relton, C. and Burn, J. and Meggitt, S. and Smith, C.H. and Allen, M.A. and Barker, J.N.W.N. and Reynolds, N.J. and Cordell, H.J. and Irvine, A.D. and McLean, W.H.I. and Sandilands, A. and Fallon, P.G.
Journal of Allergy and Clinical Immunology 132 (5): 1121-1129. November 2013

Natural selection and pain meet at a sodium channel.
Lewin, G.R.
Science 342 (6157): 428-429. 25 October 2013

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Scheller, M. and Schönheit, J. and Zimmermann, K. and Leser, U. and Rosenbauer, F. and Leutz, A.
Journal of Experimental Medicine 210 (11): 2239-2256. 21 October 2013

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. and Yu, Y. and Milanovic, M. and Beuster, G. and Zasada, C. and Däbritz, J.H.M. and Lisec, J. and Lenze, D. and Gerhardt, A. and Schleicher, K. and Kratzat, S. and Purfürst, B. and Walenta, S. and Mueller-Klieser, W. and Gräler, M. and Hummel, M. and Keller, U. and Buck, A.K. and Dörken, B. and Willmitzer, L. and Reimann, M. and Kempa, S. and Lee, S. and Schmitt, C.A.
Nature 501 (7467): 421-425. 19 September 2013

Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.
Beed, P. and Gundlfinger, A. and Schneiderbauer, S. and Song, J. and Boehm, C. and Burgalossi, A. and Brecht, M. and Vida, I. and Schmitz, D.
Neuron 79 (6): 1197-1207. 18 September 2013

Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.
Kintscher, M. and Wozny, C. and Johenning, F.W. and Schmitz, D. and Breustedt, J.
Nature Communications 4 : 2392. 3 September 2013

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E. and Mah, N. and Naumann, H. and Pongrac, I.M. and Cerdá-Esteban, N. and Fontaine, J.F. and Wang, Y. and Chen, W. and Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27 (17): 1932-1946. 1 September 2013

Accurate and universal delineation of prokaryotic species.
Mende, D.R. and Sunagawa, S. and Zeller, G. and Bork, P.
Nature Methods 10 (9): 881-884. September 2013

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I. and Gross, J. and Baumann, D. and Korn, C. and Kerr, G. and Grigoryan, T. and Mauch, C. and Birchmeier, W. and Boutros, M.
Journal of Experimental Medicine 210 (9): 1761-1777. 26 August 2013

Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits.
Megraw, M. and Mukherjee, S. and Ohler, U.
Genome Biology 14 (8): R85. 23 August 2013

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur, S.S. and Diaz, A.G. and Maratou, K. and Sarkis, A. and Rotival, M. and Game, L. and Tschannen, M.R. and Kaisaki, P.J. and Otto, G.W. and John Ma, M.C. and Keane, T.M. and Hummel, O. and Saar, K. and Chen, W. and Guryev, V. and Gopalakrishnan, K. and Garrett, M.R. and Joe, B. and Citterio, L. and Bianchi, G. and McBride, M. and Dominiczak, A. and Adams, D.J. and Serikawa, T. and Flicek, P. and Cuppen, E. and Hubner, N. and Petretto, E. and Gauguier, D. and Kwitek, A. and Jacob, H. and Aitman, T.J.
Cell 154 (3): 691-703. 1 August 2013

Orchestrated intron retention regulates normal granulocyte differentiation.
Wong, J.J.L. and Ritchie, W. and Ebner, O.A. and Selbach, M. and Wong, J.W.H. and Huang, Y. and Gao, D. and Pinello, N. and Gonzalez, M. and Baidya, K. and Thoeng, A. and Khoo, T.L. and Bailey, C.G. and Holst, J. and Rasko, J.E.J.
Cell 154 (3): 583-595. 1 August 2013

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo, J. and Schaarschmidt, H. and Liang, L. and Cookson, W. and Bauerfeind, A. and Lee-Kirsch, M.A. and Nemat, K. and Henderson, J. and Paternoster, L. and Harper, J.L. and Mangold, E. and Nothen, M.M. and Rüschendorf, F. and Kerscher, T. and Marenholz, I. and Matanovic, A. and Lau, S. and Keil, T. and Bauer, C.P. and Kurek, M. and Ciechanowicz, A. and Macek, M. and Franke, A. and Kabesch, M. and Hubner, N. and Abecasis, G. and Weidinger, S. and Moffatt, M. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 132 (2): 371-377. August 2013

Bio++: efficient extensible libraries and tools for computational molecular evolution.
Gueguen, L. and Gaillard, S. and Boussau, B. and Gouy, M. and Groussin, M. and Rochette, N.C. and Bigot, T. and Fournier, D. and Pouyet, F. and Cahais, V. and Bernard, A. and Scornavacca, C. and Nabholz, B. and Haudry, A. and Dachary, L. and Galtier, N. and Belkhir, K. and Dutheil, J.Y.
Molecular Biology and Evolution 30 (8): 1745-1750. August 2013

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice.
Krebs, K. and Böttinger, N. and Huang, L.R. and Chmielewski, M. and Arzberger, S. and Gasteiger, G. and Jäger, C. and Schmitt, E. and Bohne, F. and Aichler, M. and Uckert, W. and Abken, H. and Heikenwalder, M. and Knolle, P. and Protzer, U.
Gastroenterology 145 (2): 456-465. August 2013

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C. and Willem, M. and Fricker, F.R. and Wende, H. and Wulf-Goldenberg, A. and Tahirovic, S. and Nave, K.A. and Saftig, P. and Haass, C. and Garratt, A.N. and Bennett, D.L. and Birchmeier, C.
EMBO Journal 32 (14): 2015-2028. 17 July 2013

Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun, W. and You, X. and Gogol-Doering, A. and He, H. and Kise, Y. and Sohn, M. and Chen, T. and Klebes, A. and Schmucker, D. and Chen, W.
EMBO Journal 32 (14): 2029-2038. 17 July 2013

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P. and Fang, L. and Zhu, Q. and Schipper, J.H. and Loddenkemper, C. and Kosel, F. and Brinkmann, V. and Eckert, K. and Hindersin, S. and Holland, J.D. and Lehr, S. and Kahn, M. and Ziebold, U. and Birchmeier, W.
EMBO Journal 32 (14): 1977-1989. 17 July 2013

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
Meder, B. and Rühle, F. and Weis, T. and Homuth, G. and Keller, A. and Franke, J. and Peil, B. and Bermejo, J.L. and Frese, K. and Huge, A. and Witten, A. and Vogel, B. and Haas, J. and Völker, U. and Ernst, F. and Teumer, A. and Ehlermann, P. and Zugck, C. and Friedrichs, F. and Kroemer, H. and Dörr, M. and Hoffmann, W. and Maisch, B. and Pankuweit, S. and Ruppert, V. and Scheffold, T. and Kühl, U. and Schultheiss, H.P. and Kreutz, R. and Ertl, G. and Angermann, C. and Charron, P. and Villard, E. and Gary, F. and Isnard, R. and Komajda, M. and Lutz, M. and Meitinger, T. and Sinner, M.F. and Wichmann, H.E. and Krawczak, M. and Ivandic, B. and Weichenhan, D. and Gelbrich, G. and El-Mokhtari, N.E. and Schreiber, S. and Felix, S.B. and Hasenfuß, G. and Pfeufer, A. and Hübner, N. and Kääb, S. and Arbustini, E. and Rottbauer, W. and Frey, N. and Stoll, M. and Katus, H.A.
European Heart Journal 35 (16): 1069-1077. 12 July 2013

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Arndt, A.K. and Schaefer, S. and Drenckhahn, J.D. and Sabeh, M.K. and Plovie, E.R. and Caliebe, A. and Klopocki, E. and Musso, G. and Werdich, A.A. and Kalwa, H. and Heinig, M. and Padera, R.F. and Wassilew, K. and Bluhm, J. and Harnack, C. and Martitz, J. and Barton, P.J. and Greutmann, M. and Berger, F. and Huebner, N. and Siebert, R. and Kramer, H.H. and Cook, S.A. and Macrae, C.A. and Klaassen, S.
American Journal of Human Genetics 93 (1): 67-77. 11 July 2013

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M. and Weissbrich, B. and Knall, R. and Franz, T. and Dössinger, G. and Bet, J. and Paszkiewicz, P.J. and Pfeifer, L. and Bunse, M. and Uckert, W. and Holtappels, R. and Gillert-Marien, D. and Neuenhahn, M. and Krackhardt, A. and Reddehase, M.J. and Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H. and Schröder, A. and Neuhofer, W. and Jantsch, J. and Kopp, C. and Karlsen, T.V. and Boschmann, M. and Goss, J. and Bry, M. and Rakova, N. and Dahlmann, A. and Brenner, S. and Tenstad, O. and Nurmi, H. and Mervaala, E. and Wagner, H. and Beck, F.X. and Müller, D.N. and Kerjaschki, D. and Luft, F.C. and Harrison, D.G. and Alitalo, K. and Titze, J.
Journal of Clinical Investigation 123 (7): 2803-2815. 1 July 2013

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud, A. and Hermsen, R. and Guryev, V. and Stridh, P. and Graham, D. and McBride, M.W. and Foroud, T. and Calderari, S. and Diez, M. and Ockinger, J. and Beyeen, A.D. and Gillett, A. and Abdelmagid, N. and Guerreiro-Cacais, A.O. and Jagodic, M. and Tuncel, J. and Norin, U. and Beattie, E. and Huynh, N. and Miller, W.H. and Koller, D.L. and Alam, I. and Falak, S. and Osborne-Pellegrin, M. and Martinez-Membrives, E. and Canete, T. and Blazquez, G. and Vicens-Costa, E. and Mont-Cardona, C. and Diaz-Moran, S. and Tobena, A. and Hummel, O. and Zelenika, D. and Saar, K. and Patone, G. and Bauerfeind, A. and Bihoreau, M.T. and Heinig, M. and Lee, Y.A. and Rintisch, C. and Schulz, H. and Wheeler, D.A. and Worley, K.C. and Muzny, D.M. and Gibbs, R.A. and Lathrop, M. and Lansu, N. and Toonen, P. and Ruzius, F.P. and de Bruijn, E. and Hauser, H. and Adams, D.J. and Keane, T. and Atanur, S.S. and Aitman, T.J. and Flicek, P. and Malinauskas, T. and Jones, E.Y. and Ekman, D. and Lopez-Aumatell, R. and Dominiczak, A.F. and Johannesson, M. and Holmdahl, R. and Olsson, T. and Gauguier, D. and Hubner, N. and Fernandez-Teruel, A. and Cuppen, E. and Mott, R. and Flint, J.
Nature Genetics 45 (7): 767-775. July 2013

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Ellinghaus, D. and Baurecht, H. and Esparza-Gordillo, J. and Rodríguez, E. and Matanovic, A. and Marenholz, I. and Hübner, N. and Schaarschmidt, H. and Novak, N. and Michel, S. and Maintz, L. and Werfel, T. and Meyer-Hoffert, U. and Hotze, M. and Prokisch, H. and Heim, K. and Herder, C. and Hirota, T. and Tamari, M. and Kubo, M. and Takahashi, A. and Nakamura, Y. and Tsoi, L.C. and Stuart, P. and Elder, J.T. and Sun, L. and Zuo, X. and Yang, S. and Zhang, X. and Hoffmann, P. and Nöthen, M.M. and Fölster-Holst, R. and Winkelmann, J. and Illig, T. and Boehm, B.O. and Duerr, R.H. and Büning, C. and Brandt, S. and Glas, J. and McAleer, M.A. and Fahy, C.M. and Kabesch, M. and Brown, S. and McLean, W.H.I. and Irvine, A.D. and Schreiber, S. and Lee, Y.A. and Franke, A. and Weidinger, S.
Nature Genetics 45 (7): 808-812. July 2013

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.
Fricker, F.R. and Antunes-Martins, A. and Galino, J. and Paramsothy, R. and La Russa, F. and Perkins, J. and Goldberg, R. and Brelstaff, J. and Zhu, N. and McMahon, S.B. and Orengo, C. and Garratt, A.N. and Birchmeier, C. and Bennett, D.L.
Brain 136 (Pt 7): 2279-2297. July 2013

From mice to man: chloride transport in leukoencephalopathy.
Jentsch, T.J.
Lancet Neurology 12 (7): 626-628. July 2013

MicroRNA target site identification by integrating sequence and binding information.
Majoros, W.H. and Lekprasert, P. and Mukherjee, N. and Skalsky, R.L. and Corcoran, D.L. and Cullen, B.R. and Ohler, U.
Nature Methods 10 (7): 630-633. July 2013

The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
Cecere, G. and Hoersch, S. and Jensen, M.B. and Dixit, S. and Grishok, A.
Molecular Cell 50 (6): 894-907. 27 June 2013

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Bagola, K. and von Delbrück, M. and Dittmar, G. and Scheffner, M. and Ziv, I. and Glickman, M.H. and Ciechanover, A. and Sommer, T.
Molecular Cell 50 (4): 528-539. 23 May 2013

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N. and Sarrazin, S. and Kandalla, P.K. and Espinosa, L. and Stanley, E.R. and Nutt, S.L. and Moore, J. and Sieweke, M.H.
Nature 497 (7448): 239-243. 9 May 2013

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C. and Grabiger, S. and Schwefel, D. and Faelber, K. and Rosenbaum, E. and Mears, J. and Rocks, O. and Daumke, O.
EMBO Journal 32 (9): 1280-1292. 2 May 2013

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld, M. and Manzel, A. and Titze, J. and Kvakan, H. and Yosef, N. and Linker, R.A. and Muller, D.N. and Hafler, D.A.
Nature 496 (7446): 518-522. 25 April 2013

It's the peptide-MHC affinity, stupid.
Kammertoens, T. and Blankenstein, T.
Cancer Cell 23 (4): 429-431. 15 April 2013

Discovery and characterization of alamandine, a novel component of the renin-angiotensin system.
Lautner, R.Q. and Villela, D.C. and Fraga-Silva, R.A. and Silva, N.C. and Verano-Braga, T. and Costa-Fraga, F. and Jankowski, J. and Jankowski, V. and De Sousa, F.B. and Alzamora, A.C. and Soares, E.R. and Barbosa, C.M. and Kjeldsen, F. and Oliveira, A.C. and Braga, J.F. and Savergnini, S.Q. and Etelvino, G.M. and Bastos Peluso, A.A. and Passos-Silva, D.G. and Ferreira, A.J. and Alves, F. and Martins, A.S. and Raizada, M.K. and Paula, R.D. and Motta-Santos, D. and Klempin, F. and Pimenta, A.M.C. and Alenina, N. and Sinisterra, R.D.M. and Bader, M. and Campagnole-Santos, M.J. and Santos, R.A.S.
Circulation Research 112 (8): 1104-1111. 12 April 2013

Barrel cortex function.
Feldmeyer, D. and Brecht, M. and Helmchen, F. and Petersen, C.C.H. and Poulet, J.F.A. and Staiger, J.F. and Luhmann, H.J. and Schwarz, C.
Progress in Neurobiology 103 : 3-27. April 2013

NextGen speaks.
Lacadie, S.A.
Science 340 (6128): 29. April 2013

A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M. and Grossmann, A. and Woodsmith, J. and Özkan, Z. and Birth, P. and Meierhofer, D. and Benlasfer, N. and Valovka, T. and Timmermann, B. and Wanker, E.E. and Sauer, S. and Stelzl, U.
Nature Methods 10 (4): 339-342. April 2013

Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry.
Veerkamp, J. and Rudolph, F. and Cseresnyes, Z. and Priller, F. and Otten, C. and Renz, M. and Schaefer, L. and Abdelilah-Seyfried, S.
Developmental Cell 24 (6): 660-667. 25 March 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Mueller-Rischart, A.K. and Pilsl, A. and Beaudette, P. and Patra, M. and Hadian, K. and Funke, M. and Peis, R. and Deinlein, A. and Schweimer, C. and Kuhn, P.H. and Lichtenthaler, S.F. and Motori, E. and Hrelia, S. and Wurst, W and Truembach, D. and Langer, T. and Krappmann, D. and Dittmar, G. and Tatzelt, J. and Winklhofer, K.F.
Molecular Cell 49 (5): 908-921. 7 March 2013

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Staber, P.B. and Zhang, P. and Ye, M. and Welner, R.S. and Nombela-Arrieta, C. and Bach, C. and Kerenyi, M. and Bartholdy, B.A. and Zhang, H. and Alberich-Jorda, M. and Lee, S. and Yang, H. and Ng, F. and Zhang, J. and Leddin, M. and Silberstein, L.E. and Hoefler, G. and Orkin, S.H. and Goettgens, B. and Rosenbauer, F. and Huang, G. and Tenen, D.G.
Molecular Cell 49 (5): 934-946. 7 March 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A. and Qadri, F. and Leukel, L. and Yilmaz, R. and Fontaine, J.F. and Sihn, G. and Bader, M. and Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123 (3): 1343-1347. 1 March 2013

Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G. and Schmidt, K. and Loddenkemper, C. and Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123 (3): 1032-1043. 1 March 2013

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Kierdorf, K. and Erny, D. and Goldmann, T. and Sander, V. and Schulz, C. and Perdiguero, E.G. and Wieghofer, P. and Heinrich, A. and Riemke, P. and Hoelscher, C. and Müller, D.N. and Luckow, B. and Brocker, T. and Debowski, K. and Fritz, G. and Opdenakker, G. and Diefenbach, A. and Biber, K. and Heikenwalder, M. and Geissmann, F. and Rosenbauer, F. and Prinz, M.
Nature Neuroscience 16 (3): 273-280. March 2013

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S. and Griesche, N. and Jastrzebska, E. and Chen, C. and Rutschow, D. and Achmüller, C. and Dorn, S. and Boesch, S.M. and Lalowski, M. and Wanker, E. and Schneider, R. and Schweiger, S.
Nature Communications 4 : 1511. 26 February 2013

Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S. and Schneider, J. and Wollersheim, T. and Assmann, A. and Bierbrauer, J. and Marg, A. and Al Hasani, H. and Chadt, A. and Wenzel, K. and Koch, S. and Fielitz, J. and Kleber, C. and Faust, K. and Mai, K. and Spies, C.D. and Luft, F.C. and Boschmann, M. and Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396. 15 February 2013

Chloride in vesicular trafficking and function.
Stauber, T. and Jentsch, T.J.
Annual Review of Physiology 75 : 453-477. 10 February 2013

Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.
Anton, F. and Dittmar, G. and Langer, T. and Escobar-Henriques, M.
Molecular Cell 49 (3): 487-498. 7 February 2013

Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease.
Kränkel, N. and Kuschnerus, K. and Müller, M. and Speer, T. and Mocharla, P. and Madeddu, P. and Bader, M. and Lüscher, T.F. and Landmesser, U.
Circulation 127 (5): 594-603. 5 February 2013

ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
An, J. and Mehrhof, F. and Harms, C. and Lättig-Tünnemann, G. and Lee, S.L.L. and Endres, M. and Li, M. and Sellge, G. and Mandic, A.D. and Trautwein, C. and Donath, S.
Journal of Hepatology 58 (2): 297-305. February 2013

(90)Yttrium-ibritumomab-tiuxetan as first-line treatment for follicular lymphoma: 30 months of follow-up data from an international multicenter phase II clinical trial.
Scholz, C.W. and Pinto, A. and Linkesch, W. and Lindén, O. and Viardot, A. and Keller, U. and Hess, G. and Lastoria, S. and Lerch, K. and Frigeri, F. and Arcamone, M. and Stroux, A. and Frericks, B. and Pott, C. and Pezzutto, A.
Journal of Clinical Oncology 31 (3): 308-313. 20 January 2013

Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes.
Uhlenhaut, N.H. and Barish, G.D. and Yu, R.T. and Downes, M. and Karunasiri, M. and Liddle, C. and Schwalie, P. and Hübner, N. and Evans, R.M.
Molecular Cell 49 (1): 158-171. 10 January 2013

Microglia: new roles for the synaptic stripper.
Kettenmann, H. and Kirchhoff, F. and Verkhratsky, A.
Neuron 77 (1): 10-18. 9 January 2013

Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Rakova, N. and Jüttner, K. and Dahlmann, A. and Schröder, A. and Linz, P. and Kopp, C. and Rauh, M. and Goller, U. and Beck, L. and Agureev, A. and Vassilieva, G. and Lenkova, L. and Johannes, B. and Wabel, P. and Moissl, U. and Vienken, J. and Gerzer, R. and Eckardt, K.U. and Müller, D.N. and Kirsch, K. and Morukov, B. and Luft, F.C. and Titze, J.
Cell Metabolism 17 (1): 125-131. 8 January 2013

Genomic variation landscape of the human gut microbiome.
Schloissnig, S. and Arumugam, M. and Sunagawa, S. and Mitreva, M. and Tap, J. and Zhu, A. and Waller, A. and Mende, D.R. and Kultima, J.R. and Martin, J. and Kota, K. and Sunyaev, S.R. and Weinstock, G.M. and Bork, P.
Nature 493 (7430): 45-50. 3 January 2013

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
Kravtsova-Ivantsiv, Y. and Sommer, T. and Ciechanover, A.
Angewandte Chemie International Edition 52 (1): 192-198. 2 January 2013

A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice.
Baddack, U. and Hartmann, S. and Bang, H. and Grobe, J. and Loddenkemper, C. and Lipp, M. and Mueller, G.
Nature Communications 4 : 1644. 2013

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K. and Nakamura, Y. and Oka, T. and Ito, H. and Tamura, T. and Tagawa, K. and Sasabe, T. and Katsuta, A. and Motoki, K. and Shiwaku, H. and Sone, M. and Yoshida, C. and Katsuno, M. and Eishi, Y. and Murata, M. and Taylor, J.P. and Wanker, E.E. and Kono, K. and Tashiro, S. and Sobue, G. and La Spada, A.R. and Okazawa, H.
Nature Communications 4 : 1816. 2013

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.
Iskar, M. and Zeller, G. and Blattmann, P. and Campillos, M. and Kuhn, M. and Kaminska, K.H. and Runz, H. and Gavin, A.C. and Pepperkok, R. and van Noort, V. and Bork, P.
Molecular Systems Biology 9 : 662. 2013

Systematic identification of proteins that elicit drug side effects.
Kuhn, M. and Al Banchaabouchi, M. and Campillos, M. and Jensen, L.J. and Gross, C. and Gavin, A.C. and Bork, P.
Molecular Systems Biology 9 : 663. 2013

Widespread splicing changes in human brain development and aging.
Mazin, P. and Xiong, J. and Liu, X. and Yan, Z. and Zhang, X. and Li, M. and He, L. and Somel, M. and Yuan, Y. and Chen, Y.P.P. and Li, N. and Hu, Y. and Fu, N. and Ning, Z. and Zeng, R. and Yang, H. and Chen, W. and Gelfand, M. and Khaitovich, P.
Molecular Systems Biology 9 : 633. 2013


Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Herse, F. and LaMarca, B. and Hubel, C.A. and Kaartokallio, T. and Lokki, A.I. and Ekholm, E. and Laivuori, H. and Gauster, M. and Huppertz, B. and Sugulle, M. and Ryan, M.J. and Novotny, S. and Brewer, J. and Park, J.K. and Kacik, M. and Hoyer, J. and Verlohren, S. and Wallukat, G. and Rothe, M. and Luft, F.C. and Muller, D.N. and Schunck, W.H. and Staff, A.C. and Dechend, R.
Circulation 126 (25): 2990-2999. 18 December 2012

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Nagel, D. and Spranger, S. and Vincendeau, M. and Grau, M. and Raffegerst, S. and Kloo, B. and Hlahla, D. and Neuenschwander, M. and von Kries, J.P. and Hadian, K. and Doerken, B. and Lenz, P. and Lenz, G. and Schendel, D.J. and Krappmann, D.
Cancer Cell 22 (6): 825-837. 11 December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S. and Raczkowski, F. and Mittruecker, H.W. and Willimsky, G. and Gerlach, K. and Kuehl, A.A. and Breiderhoff, T. and Willnow, T.E. and Doerken, B. and Hoepken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G. and Rump, A. and Schulz, H. and Stricker, S. and Schulze, L. and Platzer, K. and Aydin, A. and Tinschert, S. and Goldring, M.B. and Luft, F.C. and Baehring, S.
Journal of Clinical Investigation 122 (11): 3990-4002. 1 November 2012

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P. and Sasaki, Y. and Godinho, S.A. and Pellerin, A. and Köchert, K. and Sleckman, B.P. and de Alboran, I.M. and Janz, M. and Rodig, S. and Rajewsky, K.
Nature Immunology 13 (11): 1092-1100. November 2012

Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat, S. and Schmidt, A. and Codlin, S. and Chen, W. and Aebersold, R. and Baehler, J.
Cell 151 (3): 671-683. 26 October 2012

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
Kaji, T. and Ishige, A. and Hikida, M. and Taka, J. and Hijikata, A. and Kubo, M. and Nagashima, T. and Takahashi, Y. and Kurosaki, T. and Okada, M. and Ohara, O. and Rajewsky, K. and Takemori, T.
Journal of Experimental Medicine 209 (11): 2079-2097. 22 October 2012

A validated regulatory network for Th17 cell specification.
Ciofani, M. and Madar, A. and Galan, C. and Sellars, M. and Mace, K. and Pauli, F. and Agarwal, A. and Huang, W. and Parkurst, C.N. and Muratet, M. and Newberry, K.M. and Meadows, S. and Greenfield, A. and Yang, Y. and Jain, P. and Kirigin, F.K. and Birchmeier, C. and Wagner, E.F. and Murphy, K.M. and Myers, R.M. and Bonneau, R. and Littman, D.R.
Cell 151 (2): 289-303. 12 October 2012

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.
Shabek, N. and Herman-Bachinsky, Y. and Buchsbaum, S. and Lewinson, O. and Haj-Yahya, M. and Hejjaoui, M. and Lashuel, H.A. and Sommer, T. and Brik, A. and Ciechanover, A.
Molecular Cell 48 (1): 87-97. 12 October 2012

Novel biomarkers for pre-diabetes identified by metabolomics.
Wang-Sattler, R. and Yu, Z. and Herder, C. and Messias, A.C. and Floegel, A. and He, Y. and Heim, K. and Campillos, M. and Holzapfel, C. and Thorand, B. and Grallert, H. and Xu, T. and Bader, E. and Huth, C. and Mittelstrass, K. and Doering, A. and Meisinger, C. and Gieger, C. and Prehn, C. and Roemisch-Margl, W. and Carstensen, M. and Xie, L. and Yamanaka-Okumura, H. and Xing, G. and Ceglarek, U. and Thiery, J. and Giani, G. and Lickert, H. and Lin, X. and Li, Y. and Boeing, H. and Joost, H.G. and de Angelis, M.H. and Rathmann, W. and Suhre, K. and Prokisch, H. and Peters, A. and Meitinger, T. and Roden, M. and Wichmann, H.E. and Pischon, T. and Adamski, J. and Illig, T.
Molecular Systems Biology 8 : 615. 25 September 2012

Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D. and Vasyutina, E. and Czajkowski, M.T. and Griger, J. and Rassek, C. and Rahn, H.P. and Purfürst, B. and Wende, H. and Birchmeier, C.
Developmental Cell 23 (3): 469-481. 11 September 2012

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51 (37): 9441-9447. 10 September 2012

Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Sander, S. and Calado, D.P. and Srinivasan, L. and Köchert, K. and Zhang, B. and Rosolowski, M. and Rodig, S.J. and Holzmann, K. and Stilgenbauer, S. and Siebert, R. and Bullinger, L. and Rajewsky, K.
Cancer Cell 22 (2): 167-179. 14 August 2012

Editorial authors' reply to Freedhoff: "Advice to avoid low carbohydrate-high protein diets is not evidence based".
Floegel, A. and Pischon, T.
British Medical Journal 345 (7869): e5109. 6 August 2012

Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M. and Schuster, S. and Juettner, R. and Parthasarathy, S. and Tarabykin, V. and Birchmeier, W.
Genes & Development 26 (15): 1743-1757. 1 August 2012

TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure.
An, J. and Harms, C. and Lättig-Tünnemann, G. and Sellge, G. and Mandic, A.D. and Malato, Y. and Heuser, A. and Endres, M. and Trautwein, C. and Donath, S.
Hepatology 56 (2): 715-726. August 2012

Finding the will and the way of ERAD substrate retrotranslocation.
Hampton, R.Y. and Sommer, T.
Current Opinion in Cell Biology 24 (4): 460-466. August 2012

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K. and Kumar, J. and Synowitz, M. and Petrosino, S. and Imperatore, R. and Smith, E.S.J. and Wend, P. and Purfürst, B. and Nuber, U.A. and Gurok, U. and Matyash, V. and Waelzlein, J.H. and Chirasani, S.R. and Dittmar, G. and Cravatt, B.F. and Momma, S. and Lewin, G.R. and Ligresti, A. and De Petrocellis, L. and Cristino, L. and Di Marzo, V. and Kettenmann, H. and Glass, R.
Nature Medicine 18 (8): 1232-1238. August 2012

Deciphering a global network of functionally associated post-translational modifications.
Minguez, P. and Parca, L. and Diella, F. and Mende, D.R. and Kumar, R. and Helmer-Citterich, M. and Gavin, A.C. and van Noort, V. and Bork, P.
Molecular Systems Biology 8 : 599. 17 July 2012

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Bywater, M.J. and Poortinga, G. and Sanij, E. and Hein, N. and Peck, A. and Cullinane, C. and Wall, M. and Cluse, L. and Drygin, D. and Anderes, K. and Huser, N. and Proffitt, C. and Bliesath, J. and Haddach, M. and Schwaebe, M.K. and Ryckman, D.M. and Rice, W.G. and Schmitt, C. and Lowe, S.W. and Johnstone, R.W. and Pearson, R.B. and McArthur, G.A. and Hannan, R.D.
Cancer Cell 22 (1): 51-65. 10 July 2012

Low carbohydrate-high protein diets.
Floegel, A. and Pischon, T.
British Medical Journal 345 (7864): e3801. 19 June 2012

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G. and Munschauer, M. and Schwanhaeusser, B. and Vasile, A. and Murakawa, Y. and Schueler, M. and Youngs, N. and Penfold-Brown, D. and Drew, K. and Milek, M. and Wyler, E. and Bonneau, R. and Selbach, M. and Dieterich, C. and Landthaler, M.
Molecular Cell 46 (5): 674-690. 8 June 2012

Experimental evidence for sparse firing in the neocortex.
Barth, A.L. and Poulet, J.F.A.
Trends in Neurosciences 35 (6): 345-355. June 2012

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.
Dizier, M.H. and Margaritte-Jeannin, P. and Madore, A.M. and Esparza-Gordillo, J. and Moffatt, M.F. and Corda, E. and Monier, F. and Guilloud-Bataille, M. and Franke, A. and Weidinger, S. and Annesi-Maesano, I. and Just, J. and Pin, I. and Kauffmann, F. and Cookson, W. and Lee, Y.A. and Laprise, C. and Lathrop, M. and Bouzigon, E. and Demenais, F.
Journal of Allergy and Clinical Immunology 129 (6): 1547-1553. June 2012

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann, S.M. and Krueger, C. and Park, B. and Derkow, K. and Rosenberger, K. and Baumgart, J. and Trimbuch, T. and Eom, G. and Hinz, M. and Kaul, D. and Habbel, P. and Kaelin, R. and Franzoni, E. and Rybak, A. and Nguyen, D. and Veh, R. and Ninnemann, O. and Peters, O. and Nitsch, R. and Heppner, F.L. and Golenbock, D. and Schott, E. and Ploegh, H.L. and Wulczyn, F.G. and Lehnardt, S.
Nature Neuroscience 15 (6): 827-835. June 2012

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
Engert, A. and Haverkamp, H. and Kobe, C. and Markova, J. and Renner, C. and Ho, A. and Zijlstra, J. and Kral, Z. and Fuchs, M. and Hallek, M. and Kanz, L. and Doehner, H. and Doerken, B. and Engel, N. and Topp, M. and Klutmann, S. and Amthauer, H. and Bockisch, A. and Kluge, R. and Kratochwil, C. and Schober, O. and Greil, R. and Andreesen, R. and Kneba, M. and Pfreundschuh, M. and Stein, H. and Eich, H.T. and Mueller, R.P. and Dietlein, M. and Borchmann, P. and Diehl, V.
Lancet 379 (9828): 1791-1799. 12 May 2012

Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours.
Yamada, T. and Waller, A.S. and Raes, J. and Zelezniak, A. and Perchat, N. and Perret, A. and Salanoubat, M. and Patil, K.R. and Weissenbach, J. and Bork, P.
Molecular Systems Biology 8 : 581. 8 May 2012

A role for GPx3 in activity of normal and leukemia stem cells.
Herault, O. and Hope, K.J. and Deneault, E. and Mayotte, N. and Chagraoui, J. and Wilhelm, B.T. and Cellot, S. and Sauvageau, M. and Andrade-Navarro, M.A. and Hebert, J. and Sauvageau, G.
Journal of Experimental Medicine 209 (5): 895-901. 7 May 2012

A genetic basis for mechanosensory traits in humans.
Frenzel, H. and Bohlender, J. and Pinsker, K. and Wohlleben, B. and Tank, J. and Lechner, S.G. and Schiska, D. and Jaijo, T. and Rueschendorf, F. and Saar, K. and Jordan, J. and Millan, J.M. and Gross, M. and Lewin, G.R.
PLoS Biology 10 (5): e1001318. 1 May 2012

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W. and Schafer, S. and Greaser, M.L. and Radke, M.H. and Liss, M. and Govindarajan, T. and Maatz, H. and Schulz, H. and Lincoln, S.E. and Parrish, A.M. and Dauksaite, V. and Vakeel, P. and Klaassen, S. and Gerull, B. and Thierfelder, L. and Regitz-Zagrosek, V. and Hacker, T.A. and Saupe, K.W. and Dec, G.W. and Ellinor, P.T. and MacRae, C.A. and Spallek, B. and Fischer, R. and Perrot, A. and Ozcelik, C. and Saar, K. and Hubner, N. and Gotthardt, M.
Nature Medicine 18 (5): 766-773. May 2012

The determinants of tumour immunogenicity.
Blankenstein, T. and Coulie, P.G. and Gilboa, E. and Jaffee, E.M.
Nature Reviews Cancer 12 (4): 307-313. April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky, D.J. and Abdalla, F.C. and Abeliovich, H. and Abraham, R.T. and Acevedo-Arozena, A. and Adeli, K. and Agholme, L. and Agnello, M. and Agostinis, P. and Milojkovic, A.
Autophagy 8 (4): 445-544. April 2012

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu, X. and Somel, M. and Tang, L. and Yan, Z. and Jiang, X. and Guo, S. and Yuan, Y.P. and He, L. and Oleksiak, A. and Zhang, Y. and Li, N. and Hu, Y. and Chen, W. and Qiu, Z. and Paeaebo, S. and Khaitovich, P.
Genome Research 22 (4): 611-622. April 2012

Sortilin: a receptor to regulate neuronal viability and function.
Nykjaer, A. and Willnow, T.E.
Trends in Neurosciences 35 (4): 261-270. April 2012

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Schwarzer, R. and Doerken, B. and Jundt, F.
Leukemia 26 (4): 806-813. April 2012

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu, L. and Ulbrich, J. and Mueller, J. and Wuestefeld, T. and Aeberhard, L. and Kress, T.R. and Muthalagu, N. and Rycak, L. and Rudalska, R. and Moll, R. and Kempa, S. and Zender, L. and Eilers, M. and Murphy, D.J.
Nature 483 (7391): 608-612. 29 March 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H. and Lechner, S.G. and Cheret, C. and Bourane, S. and Kolanczyk, M.E. and Pattyn, A. and Reuter, K. and Munier, F.L. and Carroll, P. and Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo, C. and Gangadharan, V. and Bali, K.K. and Xie, R.G. and Agarwal, N. and Kurejova, M. and Tappe-Theodor, A. and Tegeder, I. and Feil, S. and Lewin, G. and Polgar, E. and Todd, A.J. and Schlossmann, J. and Hofmann, F. and Liu, D.L. and Hu, S.J. and Feil, R. and Kuner, T. and Kuner, R.
PLoS Biology 10 (3): e1001283. 13 March 2012

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Jeworutzki, E. and Lopez-Hernandez, T. and Capdevila-Nortes, X. and Sirisi, S. and Bengtsson, L. and Montolio, M. and Zifarelli, G. and Arnedo, T. and Mueller, C.S. and Schulte, U. and Nunes, V. and Martinez, A. and Jentsch, T.J. and Gasull, X. and Pusch, M. and Estevez, R.
Neuron 73 (5): 951-961. 8 March 2012

It takes two to tango: IκBs, the multifunctional partners of NF-κB.
Hinz, M. and Coel Arslan, S. and Scheidereit, C.
Immunological Reviews 246 (1): 59-76. March 2012

NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia.
Terwey, T.H. and Vega-Ruiz, A. and Hemmati, P.G. and Martus, P. and Dietz, E. and le Coutre, P. and Massenkeil, G. and Doerken, B. and Arnold, R.
Leukemia 26 (3): 536-542. March 2012

Extrinsic notch ligand delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Napp, L.C. and Augustynik, M. and Paesler, F. and Krishnasamy, K. and Woiterski, J. and Limbourg, A. and Bauersachs, J. and Drexler, H. and Le Noble, F. and Limbourg, F.P.
Circulation Research 110 (4): 530-550. 17 February 2012

Bmp signaling exerts opposite effects on cardiac differentiation.
de Pater, E. and Ciampricotti, M. and Priller, F. and Veerkamp, J. and Strate, I. and Smith, K. and Lagendijk, A.K. and Schilling, T.F. and Herzog, W. and Abdelilah-Seyfried, S. and Hammerschmidt, M. and Bakkers, J.
Circulation Research 110 (4): 578-587. 17 February 2012

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A. and Christa, A. and Kur, E. and Lioubinski, O. and Bachmann, S. and Willnow, T.E. and Hammes, A.
Developmental Cell 22 (2): 268-278. 14 February 2012

Combined RNAi and localization for functionally dissecting long noncoding RNAs.
Chakraborty, D. and Kappei, D. and Theis, M. and Nitzsche, A. and Ding, L. and Paszkowski-Rogacz, M. and Surendranath, V. and Berger, N. and Schulz, H. and Saar, K. and Hubner, N. and Buchholz, F.
Nature Methods 9 (4): 360-362. 12 February 2012

Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss.
Baumann, M. and Giunta, C. and Krabichler, B. and Rueschendorf, F. and Zoppi, N. and Colombi, M. and Bittner, R.E. and Quijano-Roy, S. and Muntoni, F. and Cirak, S. and Schreiber, G. and Zou, Y. and Hu, Y. and Romero, N.B. and Carlier, R.Y. and Amberger, A. and Deutschmann, A. and Straub, V. and Rohrbach, M. and Steinmann, B. and Rostasy, K. and Karall, D. and Boennemann, C.G. and Zschocke, J. and Fauth, C.
American Journal of Human Genetics 90 (2): 201-216. 10 February 2012

Rats, salt, and history.
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Cell Metabolism 15 (2): 129-130. 8 February 2012

Targeting MET in cancer: rationale and progress.
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CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
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Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
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KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
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The molecular basis of acid insensitivity in the African naked mole-rat.
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Science 334 (6062): 1557-1560. 16 December 2011

Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
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In vivo and transcriptome-wide identification of RNA binding protein target sites.
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Luminal CD4 + T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
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Gastroenterology 141 (6): 2130-2139.e11. December 2011

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
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PLoS Biology 9 (12): e1001214. December 2011

Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study.
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Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group.
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PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactose.
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Acta Crystallographica Section D 67 (Pt 11): 936-944. November 2011

Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function.
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Immunity 35 (4): 514-525. 28 October 2011

Inflammatory skin and bowel disease linked to ADAM17 deletion.
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New England Journal of Medicine 365 (16): 1502-1508. 20 October 2011

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
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Coherent phasic excitation during hippocampal ripples.
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Neuron 72 (1): 137-152. 6 October 2011

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
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Nature 478 (7367): 114-118. 6 October 2011

Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
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Nature 478 (7367): 57-63. 6 October 2011

BCL9-2 promotes early stages of intestinal tumor progression.
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Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
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Nature Protocols 6 (10): 1521-1535. October 2011

Crystal structure of nucleotide-free dynamin.
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Nature 477 (7366): 556-560. 29 September 2011

Urinary sodium excretion and cardiovascular disease mortality.
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JAMA: Journal of the American Medical Association 306 (10): 1083. 14 September 2011

Heart development: mitochondria in command of cardiomyocyte differentiation.
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Developmental Cell 21 (3): 392-393. 13 September 2011

Severe peripheral arterial disease during nilotinib therapy.
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Journal of the National Cancer Institute 103 (17): 1347-1348. 7 September 2011

Stem cells: Orphan receptors find a home.
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Nature 476 (7360): 287-288. 18 August 2011

Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling.
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
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Photocontrol of contracting muscle fibers.
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Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
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Molecular Cell 43 (3): 340-352. 5 August 2011

Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
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Journal of Experimental Medicine 208 (8): 1585-1593. 1 August 2011

Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
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Journal of the National Cancer Institute 103 (13): 1018-1036. 6 July 2011

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
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Nature Neuroscience 14 (8): 993-1000. 3 July 2011

De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
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Genome Research 21 (7): 1193-1200. July 2011

Ca(2+)-activated Cl(-) currents are dispensable for olfaction.
Billig, G.M. and Pal, B. and Fidzinski, P. and Jentsch, T.J.
Nature Neuroscience 14 (6): 763-769. June 2011

Lrp5 functions in bone to regulate bone mass.
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Nature Medicine 17 (6): 684-691. June 2011

Global quantification of mammalian gene expression control.
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Nature 473 (7347): 337-342. 19 May 2011

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
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Journal of Cell Biology 193 (4): 785-798. 16 May 2011

Enterotypes of the human gut microbiome.
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Nature 473 (7346): 174-180. 12 May 2011

Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula.
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Pathogenesis of non-Hodgkin's lymphoma.
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Platelet-derived serotonin links vascular disease and tissue fibrosis.
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Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
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Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
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Physiology of microglia.
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Synaptic mechanisms underlying sparse coding of active touch.
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Neuron 69 (6): 1160-1175. 24 March 2011

CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia.
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American Journal of Human Genetics 88 (3): 333-343. 11 March 2011

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
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Nature Immunology 12 (3): 239-246. March 2011

The Ngal reporter mouse detects the response of the kidney to injury in real time.
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Nature Medicine 17 (2): 216-222. February 2011

A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
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Nature Protocols 6 (3): 359-364. February 2011

Pathophysiology and management of hypokalemia: a clinical perspective.
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Nature Reviews Nephrology 7 (2): 75-84. February 2011

The molecular and cellular identity of peripheral osmoreceptors.
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Neuron 69 (2): 332-344. 27 January 2011

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
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Nature Neuroscience 14 (1): 54-61. January 2011


Integrative analysis of the caenorhabditis elegans genome by the modENCODE project.
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Science 330 (6012): 1775-1787. 24 December 2010

An embedded subnetwork of highly active neurons in the neocortex.
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Neuron 68 (6): 1043-1050. 22 December 2010

Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer Randomized Trial 40954.
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Journal of Clinical Oncology 28 (35): 5210-5218. 10 December 2010

Structure of a classical MHC class I molecule that binds "non-classical" ligands.
Hee, C.S. and Gao, S. and Loll, B. and Miller, M.M. and Uchanska-Ziegler, B. and Daumke, O. and Ziegler, A.
PLoS Biology 8 (12): e1000557. 7 December 2010

Divergent effects of central and peripheral renin on body weight and metabolism.
Luft, F.C.
Cell Metabolism 12 (5): 423-424. 3 November 2010

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M. and Wilde, S. and Spranger, S. and Milosevic, S. and Frankenberger, B. and Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B. and Haftmann, C. and Sgouroudis, E. and Kuehl, A.A. and Hegazy, A.N. and Panse, I. and Riedel, R. and Flossdorf, M. and Dong, J. and Fuhrmann, F. and Heinz, G.A. and Fang, Z. and Li, N. and Bissels, U. and Hatam, F. and Jahn, A. and Hammoud, B. and Matz, M. and Schulze, F.M. and Baumgrass, R. and Bosio, A. and Mollenkopf, H.J. and Gruen, J. and Thiel, A. and Chen, W. and Hoefer, T. and Loddenkemper, C. and Loehning, M. and Chang, H.D. and Rajewsky, N. and Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11 (11): 1057-1062. November 2010

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.
Buchberger, A. and Bukau, B. and Sommer, T.
Molecular Cell 40 (2): 238-252. 22 October 2010

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N. and Fujimoto, M. and Tan, K. and Prakasam, R. and Shinkawa, T. and Li, L. and Ichikawa, H. and Takii, R. and Nakai, A.
EMBO Journal 29 (20): 3459-3469. 20 October 2010

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Orinska, Z. and Foeger, N. and Huber, M. and Marschall, J. and Mirghomizadeh, F. and Du, X. and Scheller, M. and Rosenstiel, P. and Goldmann, T. and Bollinger, A. and Beutler, B.A. and Bulfone-Paus, S.
Blood 116 (15): 2665-2675. 14 October 2010

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz, M. and Stilmann, M. and Coel Arslan, S. and Khanna, K.K. and Dittmar, G. and Scheidereit, C.
Molecular Cell 40 (1): 63-74. 8 October 2010

ClC-3-A granular anion transporter involved in insulin secretion?
Jentsch, T.J. and Maritzen, T. and Keating, D.J. and Zdebik, A.A. and Thevenod, F.
Cell Metabolism 12 (4): 307-308. 6 October 2010

Novel baroreflex activation therapy in resistant hypertension results of a European multi-center feasibility study.
Scheffers, I.J. and Kroon, A.A. and Schmidli, J. and Jordan, J. and Tordoir, J.J. and Mohaupt, M.G. and Luft, F.C. and Haller, H. and Menne, J. and Engeli, S. and Ceral, J. and Eckert, S. and Erglis, A. and Narkiewicz, K. and Philipp, T. and de Leeuw, P.W.
Journal of the American College of Cardiology 56 (15): 1254-1258. 5 October 2010

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V. and Radbruch, H. and Glumm, R. and Niesner, R. and Paterka, M. and Herz, J. and Leuenberger, T. and Lehmann, S.M. and Luenstedt, S. and Rinnenthal, J.L. and Laube, G. and Luche, H. and Lehnardt, S. and Fehling, H.J. and Griesbeck, O. and Zipp, F.
Immunity 33 (3): 424-436. 24 September 2010

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M. and Petretto, E. and Wallace, C. and Bottolo, L. and Rotival, M. and Lu, H. and Li, Y. and Sarwar, R. and Langley, S.R. and Bauerfeind, A. and Hummel, O. and Lee, Y.A. and Paskas, S. and Rintisch, C. and Saar, K. and Cooper, J. and Buchan, R. and Gray, E.E. and Cyster, J.G. and Braund, P. and Gracey, J. and Krishnan, U. and Moore, J.S. and Nelson, C.P. and Pollard, H. and Attwood, T. and Crisp-Hihn, A. and Foad, N. and Jolley, J. and Lloyd-Jones, H. and Muir, D. and Murray, E. and O'Leary, K. and Rankin, A. and Sambrook, J. and Godfroy, T. and Brocheton, J. and Proust, C. and Schmitz, G. and Heimerl, S. and Lugauer, I. and Belz, S. and Gulde, S. and Linsel-Nitschke, P. and Sager, H. and Schroeder, L. and Lundmark, P. and Syvannen, A.C. and Neudert, J. and Scholz, M. and Deloukas, P. and Gray, E. and Gwilliams, R. and Niblett, D. and Erdmann, J. and Hengstenberg, C. and Maouche, S. and Ouwehand, W.H. and Rice, C.M. and Samani, N.J. and Schunkert, H. and Goodall, A.H. and Schulz, H. and Roider, H.G. and Vingron, M. and Blankenberg, S. and Muenzel, T. and Zeller, T. and Szymczak, S. and Ziegler, A. and Tiret, L. and Smyth, D.J. and Pravenec, M. and Aitman, T.J. and Cambien, F. and Clayton, D. and Todd, J.A. and Huebner, N. and Cook, S.A.
Nature 467 (7314): 460-464. 23 September 2010

Effect of binge drinking on the heart as assessed by cardiac magnetic resonance imaging.
Zagrosek, A. and Messroghli, D. and Schulz, O. and Dietz, R. and Schulz-Menger, J.
JAMA: Journal of the American Medical Association 304 (12): 1328-1330. 22 September 2010

Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Eich, H.T. and Diehl, V. and Goergens, H. and Pabst, T. and Markova, J. and Debus, J. and Ho, A. and Doerken, B. and Rank, A. and Grosu, A.L. and Wiegel, T. and Karstens, J.H. and Greil, R. and Willich, N. and Schmidberger, H. and Doehner, H. and Borchmann, P. and Mueller-Hermelink, H.K. and Mueller, R.P. and Engert, A.
Journal of Clinical Oncology 28 (27): 4199-4206. 20 September 2010

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby, M. and Andersen, O.M. and Breiderhoff, T. and Fjorback, A.W. and Pedersen, K.M. and Madsen, P. and Jansen, P. and Heeren, J. and Willnow, T.E. and Nykjaer, A.
Cell Metabolism 12 (3): 213-223. 8 September 2010

Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P. and Lampert, J.C. and Chen, X. and Leitao, C. and Popovic, J. and Mueller, W. and Blankenstein, T.
Nature Medicine 16 (9): 1029-1034. September 2010

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
Somel, M. and Guo, S. and Fu, N. and Yan, Z. and Hu, H.Y. and Xu, Y. and Yuan, Y. and Ning, Z. and Hu, Y. and Menzel, C. and Hu, H. and Lachmann, M. and Zeng, R. and Chen, W. and Khaitovich, P.
Genome Research 20 (9): 1207-1218. September 2010

Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert, A. and Pluetschow, A. and Eich, H.T. and Lohri, A. and Doerken, B. and Borchmann, P. and Berger, B. and Greil, R. and Willborn, K.C. and Wilhelm, M. and Debus, J. and Eble, M.J. and Soekler, M. and Ho, A. and Rank, A. and Ganser, A. and Truemper, L. and Bokemeyer, C. and Kirchner, H. and Schubert, J. and Kral, Z. and Fuchs, M. and Mueller-Hermelink, H.K. and Mueller, R.P. and Diehl, V.
New England Journal of Medicine 363 (7): 640-652. 12 August 2010

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patients.
Munoz Saravia, S.G. and Haberland, A. and Bartel, S. and Araujo, R. and Valda, G. and Duchen, D. and Diaz Ramirez, I. and Borges, A.C. and Wallukat, G. and Schimke, I.
Journal of the American College of Cardiology 56 (6): 526-527. 3 August 2010

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao, G. and Clifton, M. and Hoette, T.M. and Mori, K. and Deng, S.X. and Qiu, A. and Viltard, M. and Williams, D. and Paragas, N. and Leete, T. and Kulkarni, R. and Li, X. and Lee, B. and Kalandadze, A. and Ratner, A.J. and Pizarro, J.C. and Schmidt-Ott, K.M. and Landry, D.W. and Raymond, K.N. and Strong, R.K. and Barasch, J.
Nature Chemical Biology 6 (8): 602-609. August 2010

The shunt problem: control of functional shunting in normal and tumour vasculature.
Pries, A.R. and Hoepfner, M. and Le Noble, F. and Dewhirst, M.W. and Secomb, T.W.
Nature Reviews Cancer 10 (8): 587-593. August 2010

Chaperones get RISC loaded.
Landthaler, M.
Molecular Cell 39 (2): 161-162. 30 July 2010

The landscape of C. elegans 3'UTRs.
Mangone, M. and Manoharan, A.P. and Thierry-Mieg, D. and Thierry-Mieg, J. and Han, T. and Mackowiak, S. and Mis, E. and Zegar, C. and Gutwein, M.R. and Khivansara, V. and Attie, O. and Chen, K. and Salehi-Ashtiani, K. and Vidal, M. and Harkins, T.T. and Bouffard, P. and Suzuki, Y. and Sugano, S. and Kohara, Y. and Rajewsky, N. and Piano, F. and Gunsalus, K.C. and Kim, J.K.
Science 329 (5990): 432-435. 23 July 2010

Loss of fish actinotrichia proteins and the fin-to-limb transition.
Zhang, J. and Wagh, P. and Guay, D. and Sanchez-Pulido, L. and Padhi, B.K. and Korzh, V. and Andrade-Navarro, M.A. and Akimenko, M.A.
Nature 466 (7303): 234-237. 8 July 2010

Developmental sensory experience balances cortical excitation and inhibition.
Dorrn, A.L. and Yuan, K. and Barker, A.J. and Schreiner, C.E. and Froemke, R.C.
Nature 465 (7300): 932-936. 17 June 2010

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G. and Weinert, S. and Rickheit, G. and Jentsch, T.J.
Science 328 (5984): 1398-1401. 11 June 2010

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S. and Jabs, S. and Supanchart, C. and Schweizer, M. and Gimber, N. and Richter, M. and Rademann, J. and Stauber, T. and Kornak, U. and Jentsch, T.J.
Science 328 (5984): 1401-1403. 11 June 2010

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch, A. and Seitz, S. and Baschant, U. and Schilling, A.F. and Illing, A. and Stride, B. and Kirilov, M. and Mandic, V. and Takacz, A. and Schmidt-Ullrich, R. and Ostermay, S. and Schinke, T. and Spanbroek, R. and Zaiss, M.M. and Angel, P.E. and Lerner, U.H. and David, J.P. and Reichardt, H.M. and Amling, M. and Schuetz, G. and Tuckermann, J.P.
Cell Metabolism 11 (6): 517-531. 9 June 2010

Fetal growth restriction results in remodeled and less efficient hearts in children.
Crispi, F. and Bijnens, B. and Figueras, F. and Bartrons, J. and Eixarch, E. and Le Noble, F. and Ahmed, A. and Gratacos, E.
Circulation 121 (22): 2427-2436. 8 June 2010

The genome sequence of the spontaneously hypertensive rat: analysis and functional significance.
Atanur, S.S. and Birol, I. and Guryev, V. and Hirst, M. and Hummel, O. and Morrissey, C. and Behmoaras, J. and Fernandez-Suarez, X.M. and Johnson, M.D. and McLaren, W.M. and Patone, G. and Petretto, E. and Plessy, C. and Rockland, K.S. and Rockland, C. and Saar, K. and Zhao, Y. and Carninci, P. and Flicek, P. and Kurtz, T. and Cuppen, E. and Pravenec, M. and Huebner, N. and Jones, S.J. and Birney, E. and Aitman, T.J.
Genome Research 20 (6): 791-803. June 2010

Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models.
Borchert, N. and Dieterich, C. and Krug, K. and Schuetz, W. and Jung, S. and Nordheim, A. and Sommer, R.J. and Macek, B.
Genome Research 20 (6): 837-486. June 2010

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z. and Froehlich, J. and Grabundzija, I. and Shirley, J.R. and Powell, H.M. and Chapman, K.M. and Ivics, Z. and Hamra, F.K.
Nature Methods 7 (6): 443-445. June 2010

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.
Zaltsman, Y. and Shachnai, L. and Yivgi-Ohana, N. and Schwarz, M. and Maryanovich, M. and Houtkooper, R.H. and Vaz, F.M. and De Leonardis, F. and Fiermonte, G. and Palmieri, F. and Gillissen, B. and Daniel, P.T. and Jimenez, E. and Walsh, S. and Koehler, C.M. and Roy, S.S. and Walter, L. and Hajnoczky, G. and Gross, A.
Nature Cell Biology 12 (6): 553-562. June 2010

Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Gao, S. and von der Malsburg, A. and Paeschke, S. and Behlke, J. and Haller, O. and Kochs, G. and Daumke, O.
Nature 465 (7297): 502-506. 27 May 2010

Ontologies in quantitative biology: a basis for comparison, integration, and discovery.
Jensen, L.J. and Bork, P.
PLoS Biology 8 (5): e1000374. 25 May 2010

Altered histone acetylation is associated with age-dependent memory impairment in mice.
Peleg, S. and Sananbenesi, F. and Zovoilis, A. and Burkhardt, S. and Bahari-Javan, S. and Agis-Balboa, R.C. and Cota, P. and Wittnam, J.L. and Gogol-Doering, A. and Opitz, L. and Salinas-Riester, G. and Dettenhofer, M. and Kang, H. and Farinelli, L. and Chen, W. and Fischer, A.
Science 328 (5979): 753-756. 7 May 2010

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M. and Linnemann, C. and Hooijkaas, A.I. and Bies, L. and de Witte, M.A. and Jorritsma, A. and Kaiser, A.D.M. and Pouw, N. and Debets, R. and Kieback, E. and Uckert, W. and Song, J.Y. and Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16 (5): 565-570, 1p following 570. May 2010

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B. and Walter, K. and Kreher, S. and Kumar, R. and Hummel, M. and Lenze, D. and Koechert, K. and Bouhlel, M.A. and Richter, J. and Soler, E. and Stadhouders, R. and Joehrens, K. and Wurster, K.D. and Callen, D.F. and Harte, M.F. and Giefing, M. and Barlow, R. and Stein, H. and Anagnostopoulos, I. and Janz, M. and Cockerill, P.N. and Siebert, R. and Doerken, B. and Bonifer, C. and Mathas, S.
Nature Medicine 16 (5): 571-579, 1p following 579. May 2010

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Stolz, A. and Ertych, N. and Kienitz, A. and Vogel, C. and Schneider, V. and Fritz, B. and Jacob, R. and Dittmar, G. and Weichert, W. and Petersen, I. and Bastians, H.
Nature Cell Biology 12 (5): 492-499. May 2010

Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V. and Vogt, J. and Radbruch, H. and Nitsch, R. and Zipp, F.
Trends in Neurosciences 33 (4): 202-210. April 2010

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E. and Pless, O. and Dittmar, G. and Knoblich, M. and Leutz, A.
EMBO Journal 29 (6): 1105-1115. 17 March 2010

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M. and Lee, S. and Loddenkemper, C. and Doerr, J.R. and Tabor, V. and Aichele, P. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17 (3): 262-272. 16 March 2010

Silencing neurotransmission with membrane-tethered toxins.
Auer, S. and Stuerzebecher, A.S. and Juettner, R. and Santos-Torres, J. and Hanack, C. and Frahm, S. and Liehl, B. and Ibanez-Tallon, I.
Nature Methods 7 (3): 229-236. March 2010

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Luber, C.A. and Cox, J. and Lauterbach, H. and Fancke, B. and Selbach, M. and Tschopp, J. and Akira, S. and Wiegand, M. and Hochrein, H. and O'Keeffe, M. and Mann, M.
Immunity 32 (2): 279-289. 26 February 2010

Evidence for a protein tether involved in somatic touch.
Hu, J. and Chiang, L.Y. and Koch, M. and Lewin, G.R.
EMBO Journal 29 (4): 855-867. 17 February 2010

Cardiac involvement in sporadic inclusion-body myositis.
Utz, W. and Schmidt, S. and Schulz-Menger, J. and Luft, F. and Spuler, S.
Circulation 121 (5): 706-708. 9 February 2010

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon their potential impact for early risk assessment in asymptomatic Chagas' patients.
Wallukat, G. and Munoz Saravia, S.G. and Haberland, A. and Bartel, S. and Araujo, R. and Valda, G. and Duchen, D. and Diaz Ramirez, I. and Borges, A.C. and Schimke, I.
Journal of the American College of Cardiology 55 (5): 463-468. 2 February 2010

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A. and Monet-Lepretre, M. and Gosele, C. and Baron-Menguy, C. and Hammes, A. and Schmidt, S. and Lemaire-Carrette, B. and Domenga, V. and Schedl, A. and Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120 (2): 433-445. 1 February 2010

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K. and Begay, V. and Smink, J.J. and Zaragoza, K. and Wiesenthal, V. and Doerken, B. and Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.
Niemeyer, M.I. and Cid, L.P. and Sepulveda, F.V. and Blanz, J. and Auberson, M. and Jentsch, T.J.
Nature Genetics 42 (1): 3. January 2010

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y. and Liska, F. and Gosele, C. and Sedova, L. and Kren, V. and Krenova, D. and Ivics, Z. and Huebner, N. and Izsvak, Z.
Genome Research 20 (1): 19-27. January 2010

Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.
Bader, M.
Annual Review of Pharmacology and Toxicology 50 : 439-65. 2010


Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C. and Hanna, J. and Hirsch, C. and Volkwein, C. and Schütz, A. and Heinemann, U. and Sommer, T. and Jarosch, E.
Molecular Cell 36 (5): 782-793. 11 December 2009

The dangers of transcription.
Mathas, S. and Misteli, T.
Cell 139 (6): 1047-1049. 11 December 2009

A fresh breeze from the ivory tower.
Birchmeier, C.
Current Opinion in Cell Biology 21 (6): 725-726. December 2009

Quantitative proteomics: a tool to assess cell differentiation.
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Current Opinion in Cell Biology 21 (6): 761-766. December 2009

Central control of fever and female body temperature by RANKL/RANK.
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Nature 462 (7272): 505-509. 26 November 2009

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M. and Hinz, M. and Coel Arslan, S. and Zimmer, A. and Schreiber, V. and Scheidereit, C.
Molecular Cell 36 (3): 365-378. 13 November 2009

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M. and Vockentanz, L. and Kharazi, S. and Huska, M.R. and Mancini, E. and Scheller, M. and Kuhl, C. and Enns, A. and Prinz, M. and Jaenisch, R. and Nerlov, C. and Leutz, A. and Andrade-Navarro, M.A. and Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41 (11): 1207-1215. November 2009

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A. and Olivier, B.J. and Goverse, G. and Vondenhoff, M.F. and Greuter, M. and Beke, P. and Kusser, K. and Hoepken, U.E. and Lipp, M. and Niederreither, K. and Blomhoff, R. and Sitnik, K. and Agace, W.W. and Randall, T.D. and de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10 (11): 1193-1199. November 2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R. and Janz, M. and Galson, D.L. and Gries, M. and Li, S. and Johrens, K. and Anagnostopoulos, I. and Doerken, B. and Mapara, M.Y. and Borghesi, L. and Kardava, L. and Roodman, G.D. and Milcarek, C. and Lentzsch, S.
Blood 114 (18): 3890-3898. 29 October 2009

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Paulmann, N. and Grohmann, M. and Voigt, J.P. and Bert, B. and Vowinckel, J. and Bader, M. and Skelin, M. and Jevsek, M. and Fink, H. and Rupnik, M. and Walther, D.J.
PLoS Biology 7 (10): e1000229. 27 October 2009

Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
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Cell 139 (2): 366-379. 16 October 2009

Ageing-related chromatin defects through loss of the NURD complex.
Pegoraro, G. and Kubben, N. and Wickert, U. and Goehler, H. and Hoffmann, K. and Misteli, T.
Nature Cell Biology 11 (10): 1261-1267. October 2009

Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius, M. and Maaskola, J. and Colombo, T. and Rahn, H.P. and Friedlaender, M.R. and Li, N. and Chen, W. and Piano, F. and Rajewsky, N.
Nature Methods 6 (10): 745-751. October 2009

Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Engert, A. and Diehl, V. and Franklin, J. and Lohri, A. and Doerken, B. and Ludwig, W.D. and Koch, P. and Haenel, M. and Pfreundschuh, M. and Wilhelm, M. and Truemper, L. and Aulitzky, W.E. and Bentz, M. and Rummel, M. and Sezer, O. and Mueller-Hermelink, H.K. and Hasenclever, D. and Loeffler, M.
Journal of Clinical Oncology 27 (27): 4548-4554. 20 September 2009

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T. and Beed, P. and Vogt, J. and Schuchmann, S. and Maier, N. and Kintscher, M. and Breustedt, J. and Schuelke, M. and Streu, N. and Kieselmann, O. and Brunk, I. and Laube, G. and Strauss, U. and Battefeld, A. and Wende, H. and Birchmeier, C. and Wiese, S. and Sendtner, M. and Kawabe, H. and Kishimoto-Suga, M. and Brose, N. and Baumgart, J. and Geist, B. and Aoki, J. and Savaskan, N.E. and Braeuer, A.U. and Chun, J. and Ninnemann, O. and Schmitz, D. and Nitsch, R.
Cell 138 (6): 1222-12235. 18 September 2009

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.
Wilde, S. and Sommermeyer, D. and Frankenberger, B. and Schiemann, M. and Milosevic, S. and Spranger, S. and Pohla, H. and Uckert, W. and Busch, D.H. and Schendel, D.J.
Blood 114 (10): 2131-2139. 3 September 2009

CLCN2 variants in idiopathic generalized epilepsy.
Kleefuss-Lie, A. and Friedl, W. and Cichon, S. and Haug, K. and Warnstedt, M. and Alekov, A. and Sander, T. and Ramirez, A. and Poser, B. and Maljevic, S. and Hebeisen, S. and Kubisch, C. and Rebstock, J. and Horvath, S. and Hallmann, K. and Dullinger, J.S. and Rau, B. and Haverkamp, F. and Beyenburg, S. and Schulz, H. and Janz, D. and Giese, B. and Muller-Newen, G. and Propping, P. and Elger, C.E. and Fahlke, C. and Lerche, H.
Nature Genetics 41 (9): 954-955. September 2009

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Vandendriessche, T. and Ivics, Z. and Izsvak, Z. and Chuah, M.K.
Blood 114 (8): 1461-1468. 20 August 2009

Ribosomal protein S7 is both a regulator and a substrate of MDM2.
Zhu, Y. and Poyurovsky, M.V. and Li, Y. and Biderman, L. and Stahl, J. and Jacq, X. and Prives, C.
Molecular Cell 35 (3): 316-326. 14 August 2009

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X. and Huang, X. and Nodland, S.E. and Mates, L. and Ma, L. and Izsvak, Z. and Ivics, Z. and Lebien, T.W. and McIvor, R.S. and Wagner, J.E. and Zhou, X.
Blood 114 (7): 1319-1330. 13 August 2009

PET imaging of leptin biodistribution and metabolism in rodents and primates.
Ceccarini, G. and Flavell, R.R. and Butelman, E.R. and Synan, M. and Willnow, T.E. and Bar-Dagan, M. and Goldsmith, S.J. and Kreek, M.J. and Kothari, P. and Vallabhajosula, S. and Muir, T.W. and Friedman, J.M.
Cell Metabolism 10 (2): 148-159. 6 August 2009

Mitochondrial vesicles: an ancient process providing new links to peroxisomes.
Andrade-Navarro, M.A. and Sanchez-Pulido, L. and McBride, H.M.
Current Opinion in Cell Biology 21 (4): 560-567. August 2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Hoepken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Doerken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y. and Tomann, P. and Andl, T. and Gallant, N.M. and Huelsken, J. and Jerchow, B. and Birchmeier, W. and Paus, R. and Piccolo, S. and Mikkola, M.L. and Morrisey, E.E. and Overbeek, P.A. and Scheidereit, C. and Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17 (1): 49-61. 21 July 2009

Heat-responsive gene expression for gene therapy.
Walther, W. and Stein, U.
Advanced Drug Delivery Reviews 61 (7-8): 641-649. 2 July 2009

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J. and Morkel, M. and Besser, D. and Budczies, J. and Kosel, F. and Brembeck, F.H. and Stein, U. and Fichtner, I. and Schlag, P.M. and Birchmeier, W.
Gastroenterology 137 (11): 165-175. July 2009

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice.
Giebeler, A. and Boekschoten, M.V. and Klein, C. and Borowiak, M. and Birchmeier, C. and Gassler, N. and Wasmuth, H.E. and Mueller, M. and Trautwein, C. and Streetz, K.L.
Gastroenterology 137 (1): 297-308. July 2009

RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Henneke, M. and Diekmann, S. and Ohlenbusch, A. and Kaiser, J. and Engelbrecht, V. and Kohlschuetter, A. and Kraetzner, R. and Madruga-Garrido, M. and Mayer, M. and Opitz, L. and Rodriguez, D. and Rueschendorf, F. and Schumacher, J. and Thiele, H. and Thoms, S. and Steinfeld, R. and Nuernberg, P. and Gaertner, J.
Nature Genetics 41 (7): 773-775. July 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U. and Prat, A. and Prozorovski, T. and Siffrin, V. and Paterka, M. and Herz, J. and Bendix, I. and Ifergan, I. and Schadock, I. and Mori, M.A. and Van Horssen, J. and Schroeter, F. and Smorodchenko, A. and Han, M.H. and Bader, M. and Steinman, L. and Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Buonamici, S. and Trimarchi, T. and Ruocco, M.G. and Reavie, L. and Cathelin, S. and Mar, B.G. and Klinakis, A. and Lukyanov, Y. and Tseng, J.C. and Sen, F. and Gehrie, E. and Li, M. and Newcomb, E. and Zavadil, J. and Meruelo, D. and Lipp, M. and Ibrahim, S. and Efstratiadis, A. and Zagzag, D. and Bromberg, J.S. and Dustin, M.L. and Aifantis, I.
Nature 459 (7249): 1000-1004. 18 June 2009

Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H. and Kleinewietfeld, M. and Qadri, F. and Park, J.K. and Fischer, R. and Schwarz, I. and Rahn, H.P. and Plehm, R. and Wellner, M. and Elitok, S. and Gratze, P. and Dechend, R. and Luft, F.C. and Mueller, D.N.
Circulation 119 (22): 2904-2912. 9 June 2009

Transposon-mediated genome manipulation in vertebrates.
Ivics, Z. and Li, M.A. and Mates, L. and Boeke, J.D. and Nagy, A. and Bradley, A. and Izsvak, Z.
Nature Methods 6 (6): 415-422. June 2009

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L. and Chuah, M.K. and Belay, E. and Jerchow, B. and Manoj, N. and Acosta-Sanchez, A. and Grzela, D.P. and Schmitt, A. and Becker, K. and Matrai, J. and Ma, L. and Samara-Kuko, E. and Gysemans, C. and Pryputniewicz, D. and Miskey, C. and Fletcher, B. and Vandendriessche, T. and Ivics, Z. and Izsvak, Z.
Nature Genetics 41 (6): 753-761. June 2009

A xenon-129 biosensor for monitoring MHC-peptide interactions.
Schlundt, A. and Kilian, W. and Beyermann, M. and Sticht, J. and Guenther, S. and Hoepner, S. and Falk, K. and Roetzschke, O. and Mitschang, L. and Freund, C.
Angewandte Chemie International Edition 48 (23): 4142-4145. 25 May 2009

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Ding, L. and Paszkowski-Rogacz, M. and Nitzsche, A. and Slabicki, M.M. and Heninger, A.K. and Vries, I.D. and Kittler, R. and Junqueira, M. and Shevchenko, A. and Schulz, H. and Huebner, N. and Doss, M.X. and Sachinidis, A. and Hescheler, J. and Iacone, R. and Anastassiadis, K. and Stewart, A.F. and Pisabarro, M.T. and Caldarelli, A. and Poser, I. and Theis, M. and Buchholz, F.
Cell Stem Cell 4 (5): 403-415. 8 May 2009

A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo, J. and Weidinger, S. and Foelster-Holst, R. and Bauerfeind, A. and Rueschendorf, F. and Patone, G. and Rohde, K. and Marenholz, I. and Schulz, F. and Kerscher, T. and Huebner, N. and Wahn, U. and Schreiber, S. and Franke, A. and Vogler, R. and Heath, S. and Baurecht, H. and Novak, N. and Rodriguez, E. and Illig, T. and Lee-Kirsch, M.A. and Ciechanowicz, A. and Kurek, M. and Piskackova, T. and Macek, M. and Lee, Y.A. and Ruether, A.
Nature Genetics 41 (5): 596-601. May 2009

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.
Huck, K. and Feyen, O. and Niehues, T. and Rueschendorf, F. and Huebner, N. and Laws, H.J. and Telieps, T. and Knapp, S. and Wacker, H.H. and Meindl, A. and Jumaa, H. and Borkhardt, A.
Journal of Clinical Investigation 119 (5): 1350-1358. May 2009

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik, A. and Neuhofer, W. and Jantsch, J. and Dahlmann, A. and Tammela, T. and Machura, K. and Park, J.K. and Beck, F.X. and Mueller, D.N. and Derer, W. and Goss, J. and Ziomber, A. and Dietsch, P. and Wagner, H. and van Rooijen, N. and Kurtz, A. and Hilgers, K.F. and Alitalo, K. and Eckardt, K.U. and Luft, F.C. and Kerjaschki, D. and Titze, J.
Nature Medicine 15 (5): 545-552. May 2009

Host cell interactome of tyrosine-phosphorylated bacterial proteins.
Selbach, M. and Paul, F.E. and Brandt, S. and Guye, P. and Daumke, O. and Backert, S. and Dehio, C. and Mann, M.
Cell Host & Microbe 5 (4): 397-403. 23 April 2009

Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y. and Chen, C. and Lisewski, U. and Wrackmeyer, U. and Radke, M. and Westermann, D. and Sauter, M. and Tschoepe, C. and Poller, W. and Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53 (14): 1219-1226. 7 April 2009

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Taufiq-Ur-Rahman, and Skupin, A. and Falcke, M. and Taylor, C.W.
Nature 458 (7238): 655-659. 2 April 2009

The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C. and Gauss, R. and Horn, S.C. and Neuber, O. and Sommer, T.
Nature 458 (7237): 453-460. 26 March 2009

In vivo-activated CD103+ Foxp3+ Tregs: of men and mice.
Roetzschke, O. and Borsellino, G. and Battistini, L. and Falk, K. and Kleinewietfeld, M.
Blood 113 (9): 2119-2120. 26 February 2009

Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
Heinz-Erian, P. and Mueller, T. and Krabichler, B. and Schranz, M. and Becker, C. and Rueschendorf, F. and Nuernberg, P. and Rossier, B. and Vujic, M. and Booth, I.W. and Holmberg, C. and Wijmenga, C. and Grigelioniene, G. and Kneepkens, C.M. and Rosipal, S. and Mistrik, M. and Kappler, M. and Michaud, L. and Doczy, L.C. and Siu, V.M. and Krantz, M. and Zoller, H. and Utermann, G. and Janecke, A.R.
American Journal of Human Genetics 84 (2): 188-196. 13 February 2009

The hair follicle as a dynamic miniorgan.
Schneider, M.R. and Schmidt-Ullrich, R. and Paus, R.
Current Biology 19 (3): R132-T142. 10 February 2009

BK channels in innate immune functions of neutrophils and macrophages.
Essin, K. and Gollasch, M. and Rolle, S. and Weissgerber, P. and Sausbier, M. and Bohn, E. and Autenrieth, I.B. and Ruth, P. and Luft, F.C. and Nauseef, W.M. and Kettritz, R.
Blood 113 (6): 1326-1331. 5 February 2009

15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig, I. and Mefford, H.C. and Sharp, A.J. and Guipponi, M. and Fichera, M. and Franke, A. and Muhle, H. and de Kovel, C. and Baker, C. and von Spiczak, S. and Kron, K.L. and Steinich, I. and Kleefuss-Lie, A.A. and Leu, C. and Gaus, V. and Schmitz, B. and Klein, K.M. and Reif, P.S. and Rosenow, F. and Weber, Y. and Lerche, H. and Zimprich, F. and Urak, L. and Fuchs, K. and Feucht, M. and Genton, P. and Thomas, P. and Visscher, F. and de Haan, G.J. and Moller, R.S. and Hjalgrim, H. and Luciano, D. and Wittig, M. and Nothnagel, M. and Elger, C.E. and Nuernberg, P. and Romano, C. and Malafosse, A. and Koeleman, B.P.C. and Lindhout, D. and Stephani, U. and Schreiber, S. and Eichler, E.E. and Sander, T.
Nature Genetics 41 (2): 160-162. February 2009

The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations.
Lang, U.E. and Hellweg, R. and Sander, T. and Gallinat, J.
Molecular Psychiatry 14 (2): 120-122. February 2009

CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells.
Kleinewietfeld, M. and Starke, M. and Mitri, D.D. and Borsellino, G. and Battistini, L. and Roetzschke, O. and Falk, K.
Blood 113 (4): 827-836. 22 January 2009

Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Li, J.Y. and Paragas, N. and Ned, R.M. and Qiu, A. and Viltard, M. and Leete, T. and Drexler, I.R. and Chen, X. and Sanna-Cherchi, S. and Mohammed, F. and Williams, D. and Lin, C.S. and Schmidt-Ott, K.M. and Andrews, N.C. and Barasch, J.
Developmental Cell 16 (1): 35-46. 20 January 2009

Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling.
Rudolph, A. and Abdel-Aty, H. and Bohl, S. and Boye, P. and Zagrosek, A. and Dietz, R. and Schulz-Menger, J.
Journal of the American College of Cardiology 53 (3): 284-291. 20 January 2009

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. and Walther, W. and Arlt, F. and Schwabe, H. and Smith, J. and Fichtner, I. and Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

An empirical framework for binary interactome mapping.
Venkatesan, K. and Rual, J.F. and Vazquez, A. and Stelzl, U. and Lemmens, I. and Hirozane-Kishikawa, T. and Hao, T. and Zenkner, M. and Xin, X. and Goh, K.I. and Yildirim, M.A. and Simonis, N. and Heinzmann, K. and Gebreab, F. and Sahalie, J.M. and Cevik, S. and Simon, C. and de Smet, A.S. and Dann, E. and Smolyar, A. and Vinayagam, A. and Yu, H. and Szeto, D. and Borick, H. and Dricot, A. and Klitgord, N. and Murray, R.R. and Lin, C. and Lalowski, M. and Timm, J. and Rau, K. and Boone, C. and Braun, P. and Cusick, M.E. and Roth, F.P. and Hill, D.E. and Tavernier, J. and Wanker, E.E. and Barabasi, A.L. and Vidal, M.
Nature Methods 6 (1): 83-90. January 2009


PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.
Decker, E. and Stellzig-Eisenhauer, A. and Fiebig, B.S. and Rau, C. and Kress, W. and Saar, K. and Rueschendorf, F. and Huebner, N. and Grimm, T. and Weber, B.H.
American Journal of Human Genetics 83 (6): 781-786. 12 December 2008

Neuroglia: the 150 years after.
Kettenmann, H. and Verkhratsky, A.
Trends in Neurosciences 31 (12): 653-659. December 2008

VPS10P-domain receptors - regulators of neuronal viability and function.
Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Nature Reviews Neuroscience 9 (12): 899-909. December 2008

A human snoRNA with microRNA-like functions.
Ender, C. and Krek, A. and Friedlaender, M.R. and Beitzinger, M. and Weinmann, L. and Chen, W. and Pfeffer, S. and Rajewsky, N. and Meister, G.
Molecular Cell 32 (4): 519-528. 21 November 2008

Protein quality control: On IPODs and other JUNQ.
Bagola, K. and Sommer, T.
Current Biology 18 (21): R1019-R1021. 11 November 2008

Angiogenesis factors and preeclampsia.
Dechend, R. and Luft, F.C.
Nature Medicine 14 (11): 1187-1188. November 2008

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B. and Kreher, S. and Anagnostopoulos, I. and Joehrens, K. and Monteleone, G. and Jundt, F. and Stein, H. and Janz, M. and Doerken, B. and Mathas, S.
Blood 112 (8): 3339-3347. 15 October 2008

Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
Drenckhahn, J.D. and Schwarz, Q.P. and Gray, S. and Laskowski, A. and Kiriazis, H. and Ming, Z. and Harvey, R.P. and Du, X.J. and Thorburn, D.R. and Cox, T.C.
Developmental Cell 15 (4): 521-533. 14 October 2008

Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex.
Farkas, L.M. and Haffner, C. and Giger, T. and Khaitovich, P. and Nowick, K. and Birchmeier, C. and Paeaebo, S. and Huttner, W.B.
Neuron 60 (1): 40-55. 9 October 2008

Biochemistry. Not comparable, but complementary.
Jensen, L.J. and Bork, P.
Science 322 (5898): 56-57. 3 October 2008

A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults.
Gotthardt, D. and Runz, H. and Keitel, V. and Fischer, C. and Flechtenmacher, C. and Wirtenberger, M. and Weiss, K.H. and Imparato, S. and Braun, A. and Hemminki, K. and Stremmel, W. and Rueschendorf, F. and Stiehl, A. and Kubitz, R. and Burwinkel, B. and Schirmacher, P. and Knisely, A.S. and Zschocke, J. and Sauer, P.
Hepatology 48 (4): 1157-1166. October 2008

Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Xi, L. and Das, A. and Zhao, Z.Q. and Merino, V.F. and Bader, M. and Kukreja, R.C.
Circulation 118 (14 Suppl): S32-S37. 30 September 2008

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U. and Shi, Y. and Wrackmeyer, U. and Fischer, R. and Chen, C. and Schirdewan, A. and Juettner, R. and Rathjen, F.G. and Poller, W. and Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205 (10): 2369-2379. 29 September 2008

Widespread changes in protein synthesis induced by microRNAs.
Selbach, M. and Schwanhaeusser, B. and Thierfelder, N. and Fang, Z. and Khanin, R. and Rajewsky, N.
Nature 455 (7209): 58-63. 4 September 2008

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
Grigoryan, T. and Wend, P. and Klaus, A. and Birchmeier, W.
Genes & Development 22 (17): 2308-2341. 1 September 2008

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Lange, M. and Kaynak, B. and Foerster, U.B. and Toenjes, M. and Fischer, J.J. and Grimm, C. and Schlesinger, J. and Just, S. and Dunkel, I. and Krueger, T. and Mebus, S. and Lehrach, H. and Lurz, R. and Gobom, J. and Rottbauer, W. and Abdelilah-Seyfried, S. and Sperling, S.
Genes & Development 22 (17): 2370-2384. 1 September 2008

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brinkmann, B.G. and Agarwal, A. and Sereda, M.W. and Garratt, A.N. and Mueller, T. and Wende, H. and Stassart, R.M. and Nawaz, S. and Humml, C. and Velanac, V. and Radyushkin, K. and Goebbels, S. and Fischer, T.M. and Franklin, R.J. and Lai, C. and Ehrenreich, H. and Birchmeier, C. and Schwab, M.H. and Nave, K.A.
Neuron 59 (4): 581-595. 28 August 2008

Autoregulation of Th1-mediated inflammation by twist1.
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Journal of Experimental Medicine 205 (8): 1889-1901. 4 August 2008

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Ebralidze, A.K. and Guibal, F.C. and Steidl, U. and Zhang, P. and Lee, S. and Bartholdy, B. and Jorda, M.A. and Petkova, V. and Rosenbauer, F. and Huang, G. and Dayaram, T. and Klupp, J. and O'Brien, K.B. and Will, B. and Hoogenkamp, M. and Borden, K.L. and Bonifer, C. and Tenen, D.G.
Genes & Development 22 (15): 2085-2092. 1 August 2008

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
Pravenec, M. and Churchill, P.C. and Churchill, M.C. and Viklicky, O. and Kazdova, L. and Aitman, T.J. and Petretto, E. and Huebner, N. and Wallace, C.A. and Zimdahl, H. and Zidek, V. and Landa, V. and Dunbar, J. and Bidani, A. and Griffin, K. and Qi, N. and Maxova, M. and Kren, V. and Mlejnek, P. and Wang, J. and Kurtz, T.W.
Nature Genetics 40 (8): 952-954. August 2008

Drug target identification using side-effect similarity.
Campillos, M. and Kuhn, M. and Gavin, A.C. and Jensen, L.J. and Bork, P.
Science 321 (5886): 263-266. 11 July 2008

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky, G. and Czeh, M. and Loddenkemper, C. and Gellermann, J. and Schmidt, K. and Wust, P. and Stein, H. and Blankenstein, T.
Journal of Experimental Medicine 205 (7): 1687-1700. 7 July 2008

Aggravation of viral hepatitis by platelet-derived serotonin.
Lang, P.A. and Contaldo, C. and Georgiev, P. and El-Badry, A.M. and Recher, M. and Kurrer, M. and Cervantes-Barragan, L. and Ludewig, B. and Calzascia, T. and Bolinger, B. and Merkler, D. and Odermatt, B. and Bader, M. and Graf, R. and Clavien, P.A. and Hegazy, A.N. and Loehning, M. and Harris, N.L. and Ohashi, P.S. and Hengartner, H. and Zinkernagel, R.M. and Lang, K.S.
Nature Medicine 14 (7): 756-761. July 2008

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L. and Carlton, P.M. and Haase, S. and Shao, L. and Winoto, L. and Kner, P. and Burke, B. and Cardoso, M.C. and Agard, D.A. and Gustafsson, M.G. and Leonhardt, H. and Sedat, J.W.
Science 320 (5881): 1332-1336. 6 June 2008

Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
Dempsie, Y. and Morecroft, I. and Welsh, D.J. and Macritchie, N.A. and Herold, N. and Loughlin, L. and Nilsen, M. and Peacock, A.J. and Harmar, A. and Bader, M. and Maclean, M.R.
Circulation 2008 (117): 2928-2937. 3 June 2008

Mutations in sarcomere protein genes in left ventricular noncompaction.
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Circulation 117 (22): 2893-2901. 3 June 2008

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer, D.E. and Bieschke, J. and Boeddrich, A. and Herbst, M. and Masino, L. and Lurz, R. and Engemann, S. and Pastore, A. and Wanker, E.E.
Nature Structural & Molecular Biology 15 (6): 558-566. June 2008

Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
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Circulation 117 (20): 2645-2656. 20 May 2008

Progress and prospects in rat genetics: a community view.
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Nature Genetics 40 (5): 516-22. May 2008

Distribution and functional impact of DNA copy number variation in the rat.
Guryev, V. and Saar, K. and Adamovic, T. and Verheul, M. and van Heesch, S. and Cook, S. and Pravenec, M. and Aitman, T. and Jacob, H. and Shull, J.D. and Huebner, N. and Cuppen, E.
Nature Genetics 40 (5): 538-545. May 2008

Wnt signalling and its impact on development and cancer.
Klaus, A. and Birchmeier, W.
Nature Reviews Cancer 8 (5): 387-398. May 2008

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J. and Fischer, J. and Paskas, S. and Heinig, M. and Schulz, H. and Goesele, C. and Heuser, A. and Fischer, R. and Schmidt, C. and Schirdewan, A. and Gross, V. and Hummel, O. and Maatz, H. and Patone, G. and Saar, K. and Vingron, M. and Weldon, S.M. and Lindpaintner, K. and Hammock, B.D. and Rohde, K. and Dietz, R. and Cook, S.A. and Schunck, W.H. and Luft, F.C. and Huebner, N.
Nature Genetics 40 (5): 529-537. May 2008

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
Petretto, E. and Sarwar, R. and Grieve, I. and Lu, H. and Kumaran, M.K. and Muckett, P.J. and Mangion, J. and Schroen, B. and Benson, M. and Punjabi, P.P. and Prasad, S.K. and Pennell, D.J. and Kiesewetter, C. and Tasheva, E.S. and Corpuz, L.M. and Webb, M.D. and Conrad, G.W. and Kurtz, T.W. and Kren, V. and Fischer, J. and Huebner, N. and Pinto, Y.M. and Pravenec, M. and Aitman, T.J. and Cook, S.A.
Nature Genetics 40 (5): 546-552. May 2008

SNP and haplotype mapping for genetic analysis in the rat.
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Nature Genetics 40 (5): 560-566. May 2008

The genome of the model beetle and pest tribolium castaneum.

Nature 452 (7190): 949-955. 24 April 2008

The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance.
Friedrich, M.G. and Abdel-Aty, H. and Taylor, A.J. and Schulz-Menger, J. and Messroghli, D. and Dietz, R.
Journal of the American College of Cardiology 51 (16): 1581-1587. 22 April 2008

Lectins in the endoplasmic reticulum: the sweet side of protein quality control.
Sommer, T. and Gauss, R.
Developmental Cell 14 (4): 463-464. 15 April 2008

Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene.
Merner, N.D. and Hodgkinson, K.A. and Haywood, A.F. and Connors, S. and French, V.M. and Drenckhahn, J.D. and Kupprion, C. and Ramadanova, K. and Thierfelder, L. and McKenna, W. and Gallagher, B. and Morris-Larkin, L. and Bassett, A.S. and Parfrey, P.S. and Young, T.L.
American Journal of Human Genetics 82 (4): 809-821. 11 April 2008

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I. and Peinado, H. and Kassen, D. and Hussenet, T. and Metzger, D. and Chambon, P. and Huber, M. and Hohl, D. and Cano, A. and Birchmeier, W. and Huelsken, J.
Nature 452 (7187): 650-653. 3 April 2008

Treatment-resistant chronic headaches and focal pachymeningitis in a 46-year-old man: a rare presentation of Wegener's granulomatosis.
Doerr, J. and Elitok, S. and Dieste, F.J. and Vogel, H.P. and Schneider, W. and Wuerfel, J. and Zipp, F. and Paul, F.
Lancet Neurology 7 (4): 368-372. April 2008

Discovering microRNAs from deep sequencing data using miRDeep.
Friedlaender, M.R. and Chen, W. and Adamidi, C. and Maaskola, J. and Einspanier, R. and Knespel, S. and Rajewsky, N.
Nature Biotechnology 26 (4): 407-415. April 2008

Sirt1 contributes critically to the redox-dependent fate of neural progenitors.
Prozorovski, T. and Schulze-Topphoff, U. and Glumm, R. and Baumgart, J. and Schroeter, F. and Ninnemann, O. and Siegert, E. and Bendix, I. and Bruestle, O. and Nitsch, R. and Zipp, F. and Aktas, O.
Nature Cell Biology 10 (4): 385-394. April 2008

Subacute coronary stent thrombosis in cancer patients.
Gross, C.M. and Posch, M.G. and Geier, C. and Olthoff, H. and Kraemer, J. and Dechend, R. and Dietz, R. and Oezcelik, C.
Journal of the American College of Cardiology 51 (12): 1232-1233. 25 March 2008

Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.
Nordlinger, B. and Sorbye, H. and Glimelius, B. and Poston, G.J. and Schlag, P.M. and Rougier, P. and Bechstein, W.O. and Primrose, J.N. and Walpole, E.T. and Finch-Jones, M. and Jaeck, D. and Mirza, D. and Parks, R.W. and Collette, L. and Praet, M. and Bethe, U. and Van Cutsem, E. and Scheithauer, W. and Gruenberger, T.
Lancet 371 (9617): 1007-1016. 22 March 2008

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Koralov, S.B. and Muljo, S.A. and Galler, G.R. and Krek, A. and Chakraborty, T. and Kanellopoulou, C. and Jensen, K. and Cobb, B.S. and Merkenschlager, M. and Rajewsky, N. and Rajewsky, K.
Cell 132 (5): 860-874. 7 March 2008

Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Hauck, L. and Harms, C. and An, J. and Rohne, J. and Gertz, K. and Endres, M. and Dietz, R. and von Harsdorf, R.
Nature Medicine 14 (3): 315-324. March 2008

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Pasternack, S.M. and von Kuegelgen, I. and Aboud, K.A. and Lee, Y.A. and Rueschendorf, F. and Voss, K. and Hillmer, A.M. and Molderings, G.J. and Franz, T. and Ramirez, A. and Nuernberg, P. and Noethen, M.M. and Betz, R.C.
Nature Genetics 40 (3): 329-334. March 2008

Protein production and purification.
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