The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

Taylor, D.M.; Aronow, B.J.; Tan, K.; Bernt, K.; Salomonis, N.; Greene, C.S.; Frolova, A.; Henrickson, S.E.; Wells, A.; Pei, L.; Jaiswal, J.K.; Whitsett, J.; Hamilton, K.E.; MacParland, S.A.; Kelsen, J.; Heuckeroth, R.O.; Potter, S.S.; Vella, L.A.; Terry, N.A.; Ghanem, L.R.; Kennedy, B.C.; Helbig, I.; Sullivan, K.E.; Castelo-Soccio, L.; Kreigstein, A.; Herse, F.; Nawijn, M.C.; Koppelman, G.H.; Haendel, M.; Harris, N.L.; Rokita, J.L.; Zhang, Y.; Regev, A.; Rozenblatt-Rosen, O.; Rood, J.E.; Tickle, T.L; Vento-Tormo, R.; Alimohamed, S.; Lek, M.; Mar, J.C.; Loomes, K.M.; Barrett, D.M.; Uapinyoying, P.; Beggs, A.H.; Agrawal, P.B.; Chen, Y.W.; Muir, A.B.; Garmire, L.X.; Snapper, S.B.; Nazarian, J.; Seeholzer, S.H.; Fazelinia, H.; Singh, L.N.; Faryabi, R.B.; Raman, P.; Dawany, N.; Xie, H.M.; Devkota, B.; Diskin, S.J.; Anderson, S.A.; Rappaport, E.F.; Peranteau, W.; Wikenheiser-Brokamp, K.A.; Teichmann, S.; Wallace, D.; Peng, T.; Ding, Y.Y.; Kim, M.S.; Xing, Y.; Kong, S.W.; Bönnemann, C.G.; Mandl, K.D.; White, P.S.

The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

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Item Type:	Review
Title:	The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution
Creators:	Taylor, D.M., Aronow, B.J., Tan, K., Bernt, K., Salomonis, N., Greene, C.S., Frolova, A. ORCID: https://orcid.org/0000-0001-5469-7366, Henrickson, S.E., Wells, A., Pei, L., Jaiswal, J.K., Whitsett, J., Hamilton, K.E., MacParland, S.A., Kelsen, J., Heuckeroth, R.O., Potter, S.S., Vella, L.A., Terry, N.A., Ghanem, L.R., Kennedy, B.C., Helbig, I., Sullivan, K.E., Castelo-Soccio, L., Kreigstein, A., Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Nawijn, M.C., Koppelman, G.H., Haendel, M., Harris, N.L., Rokita, J.L., Zhang, Y., Regev, A., Rozenblatt-Rosen, O., Rood, J.E., Tickle, T.L, Vento-Tormo, R., Alimohamed, S., Lek, M., Mar, J.C., Loomes, K.M., Barrett, D.M., Uapinyoying, P., Beggs, A.H., Agrawal, P.B., Chen, Y.W., Muir, A.B., Garmire, L.X., Snapper, S.B., Nazarian, J., Seeholzer, S.H., Fazelinia, H., Singh, L.N., Faryabi, R.B., Raman, P., Dawany, N., Xie, H.M., Devkota, B., Diskin, S.J., Anderson, S.A., Rappaport, E.F., Peranteau, W., Wikenheiser-Brokamp, K.A., Teichmann, S., Wallace, D., Peng, T., Ding, Y.Y., Kim, M.S., Xing, Y., Kong, S.W., Bönnemann, C.G., Mandl, K.D. and White, P.S.
Abstract:	Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
Keywords:	Developmental Gene Expression Regulation, Embryonic Development, Gene Expression Profiling, Gene Regulatory Networks, Pediatrics, Single-Cell Analysis, Tissue Distribution
Source:	Developmental Cell
ISSN:	1534-5807
Publisher:	Cell Press
Volume:	49
Number:	1
Page Range:	10-29
Date:	8 April 2019
Official Publication:	https://doi.org/10.1016/j.devcel.2019.03.001
PubMed:	View item in PubMed

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