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High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial.
Schorb, E. and Isbell, L.K. and Kerkhoff, A. and Mathas, S. and Braulke, F. and Egerer, G. and Röth, A. and Schliffke, S. and Borchmann, P. and Brunnberg, U. and Kroschinsky, F. and Möhle, R. and Rank, A. and Wellnitz, D. and Kasenda, B. and Pospiech, L. and Wendler, J. and Scherer, F. and Deckert, M. and Henkes, E. and von Gottberg, P. and Gmehlin, D. and Backenstraß, M. and Jensch, A. and Burger-Martin, E. and Grishina, O. and Fricker, H. and Malenica, N. and Orbán, A. and Duyster, J. and Ihorst, G. and Finke, J. and Illerhaus, G.
Lancet Haematology 11 (3): e196-e205. March 2024

Tackling metabolic defects in HFpEF.
Wang, R. and Schiattarella, G.G.
European Heart Journal : ehad884. 17 February 2024 (In Press)

Structural insights into the activation mechanism of antimicrobial GBP1.
Weismehl, M. and Chu, X. and Kutsch, M. and Lauterjung, P. and Herrmann, C. and Kudryashev, M. and Daumke, O.
EMBO Journal 43 (4): 615-636. 15 February 2024

The cycling and aging mouse female reproductive tract at single-cell resolution.
Winkler, I. and Tolkachov, A. and Lammers, F. and Lacour, P. and Daugelaite, K. and Schneider, N. and Koch, M.L. and Panten, J. and Grünschläger, F. and Poth, T. and Ávila, B.M.d. and Schneider, A. and Haas, S. and Odom, D.T. and Gonçalves, Â.
Cell 187 (4): 981-998.e25. 15 February 2024

Genetic determinants of micronucleus formation in vivo.
Adams, D.J. and Barlas, B. and McIntyre, R.E. and Salguero, I. and van der Weyden, L. and Barros, A. and Vicente, J.R. and Karimpour, N. and Haider, A. and Ranzani, M. and Turner, G. and Thompson, N.A. and Harle, V. and Olvera-León, R. and Robles-Espinoza, C.D. and Speak, A.O. and Geisler, N. and Weninger, W.J. and Geyer, S.H. and Hewinson, J. and Karp, N.A. and Fu, B. and Yang, F. and Kozik, Z. and Choudhary, J. and Yu, L. and van Ruiten, M.S. and Rowland, B.D. and Lelliott, C.J. and Del Castillo Velasco-Herrera, M. and Verstraten, R. and Bruckner, L. and Henssen, A.G. and Rooimans, M.A. and de Lange, J. and Mohun, T.J. and Arends, M.J. and Kentistou, K.A. and Coelho, P.A. and Zhao, Y. and Zecchini, H. and Perry, J.R.B. and Jackson, S.P. and Balmus, G.
Nature 14 February 2024 (In Press)

Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Juul-Madsen, K. and Parbo, P. and Ismail, R. and Ovesen, P.L. and Schmidt, V. and Madsen, L.S. and Thyrsted, J. and Gierl, S. and Breum, M. and Larsen, A. and Andersen, M.N. and Romero-Ramos, M. and Holm, C.K. and Andersen, G.R. and Zhao, H. and Schuck, P. and Nygaard, J.V. and Sutherland, D.S. and Eskildsen, S.F. and Willnow, T.E. and Brooks, D.J. and Vorup-Jensen, T.
Nature Communications 15 (1): 1224. 9 February 2024

Functional and evolutionary significance of unknown genes from uncultivated taxa.
Rodríguez Del Río, Á. and Giner-Lamia, J. and Cantalapiedra, C.P. and Botas, J. and Deng, Z. and Hernández-Plaza, A. and Munar-Palmer, M. and Santamaría-Hernando, S. and Rodríguez-Herva, J.J. and Ruscheweyh, H.J. and Paoli, L. and Schmidt, T.S.B. and Sunagawa, S. and Bork, P. and López-Solanilla, E. and Coelho, L.P. and Huerta-Cepas, J.
Nature 626 (7998): 377-384. 8 February 2024

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J. and Calvo-Enrique, L. and Paricio-Montesinos, R. and Kumar, R. and Zhang, M.D. and Poulet, J.F.A. and Ernfors, P. and Lewin, G.R.
Nature Communications 15 (1): 898. 6 February 2024

Structure and function of the hippocampal CA3 module.
Sammons, R.P. and Vezir, M. and Moreno-Velasquez, L. and Cano, G. and Orlando, M. and Sievers, M. and Grasso, E. and Metodieva, V.D. and Kempter, R. and Schmidt, H. and Schmitz, D.
Proceedings of the National Academy of Sciences of the United States of America 121 (6): e2312281120. 6 February 2024

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
Company, C. and Schmitt, M.J. and Dramaretska, Y. and Serresi, M. and Kertalli, S. and Jiang, B. and Yin, J.A. and Aguzzi, A. and Barozzi, I. and Gargiulo, G.
Nature Communications 15 (1): 897. 5 February 2024

ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C. and Thery, F. and Wirth, E.K. and Ochs, S. and Kespohl, M. and Kleinau, G. and Kelm, N. and Gimber, N. and Schmoranzer, J. and Voss, M. and Klingel, K. and Spranger, J. and Renko, K. and Ralser, M. and Mülleder, M. and Heuser, A. and Knobeloch, K.P. and Scheerer, P. and Kirwan, J. and Brüning, U. and Berndt, N. and Impens, F. and Beling, A.
Cardiovascular Research 3 February 2024 (In Press)

Gamma oscillation plasticity is mediated via parvalbumin interneurons.
Hadler, M.D. and Tzilivaki, A. and Schmitz, D. and Alle, H. and Geiger, J.R.P.
Science Advances 10 (5): eadj7427. 2 February 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. and Wirtz, T. and Weber, T. and Lebedin, M. and Lowenstein, E.D. and Sommermann, T. and Zach, A. and Yasuda, T. and de la Rosa, K. and Chu, V.T. and Schulte, J.H. and Müller, I. and Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024

A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea.
Mottaghinia, S. and Stenzel, S. and Tsangaras, K. and Nikolaidis, N. and Laue, M. and Müller, K. and Hölscher, H. and Löber, U. and McEwen, G.K. and Donnellan, S.C. and Rowe, K.C. and Aplin, K.P. and Goffinet, C. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 121 (6): e2220392121. 1 February 2024

Genetic characterization of primary mediastinal B-cell lymphoma: pathogenesis and patient outcomes.
Noerenberg, D. and Briest, F. and Hennch, C. and Yoshida, K. and Hablesreiter, R. and Takeuchi, Y. and Ueno, H. and Staiger, A.M. and Ziepert, M. and Asmar, F. and Locher, B.N. and Toth, E. and Weber, T. and Amini, R.M. and Klapper, W. and Bouzani, M. and Poeschel, V. and Rosenwald, A. and Held, G. and Campo, E. and Ishaque, N. and Stamatopoulos, K. and Kanellis, G. and Anagnostopoulos, I. and Bullinger, L. and Goldschmidt, N. and Zinzani, P.L. and Bödör, C. and Rosenquist, R. and Vassilakopoulos, T.P. and Ott, G. and Ogawa, S. and Damm, F.
Journal of Clinical Oncology 42 (4): 452-466. 1 February 2024

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M. and Serve, S. and Marx, A.F. and Fadejeva, J. and Saikali, P. and Dzamukova, M. and Durán-Hernández, N. and Kommer, C. and Heinrich, F. and Durek, P. and Heinz, G.A. and Höfer, T. and Mashreghi, M.F. and Kühn, R. and Pinschewer, D.D. and Löhning, M.
Nature Immunology 25 (2): 256-267. February 2024

CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting.
Graham, S. and Vu, Q.D. and Jahanifar, M. and Weigert, M. and Schmidt, U. and Zhang, W. and Zhang, J. and Yang, S. and Xiang, J. and Wang, X. and Rumberger, J.L. and Baumann, E. and Hirsch, P. and Liu, L. and Hong, C. and Aviles-Rivero, A.I. and Jain, A. and Ahn, H. and Hong, Y. and Azzuni, H. and Xu, M. and Yaqub, M. and Blache, M.C. and Piégu, B. and Vernay, B. and Scherr, T. and Böhland, M. and Löffler, K. and Li, J. and Ying, W. and Wang, C. and Snead, D. and Raza, S.E.A. and Minhas, F. and Rajpoot, N.M.
Medical Image Analysis 92 : 103047. February 2024

Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia.
Koslowski, S. and Glauben, R. and Habringer, S. and Burmeister, T. and Keller, U. and Brüggemann, M. and Gökbuget, N. and Schwartz, S.
Haematologica 109 (2): 661-665. February 2024

The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma.
Pan, X. and AbdulJabbar, K. and Coelho-Lima, J. and Grapa, A.I. and Zhang, H. and Cheung, A.H.K. and Baena, J. and Karasaki, T. and Wilson, C.R. and Sereno, M. and Veeriah, S. and Aitken, S.J. and Hackshaw, A. and Nicholson, A.G. and Jamal-Hanjani, M. and Swanton, C. and Yuan, Y. and Le Quesne, J. and Moore, D.A.
Nature Cancer 5 (2): 347-363. February 2024

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y. and Leney-Greene, M. and Lynberg, M. and Gabrielski, J.Q. and Xu, X. and Schwarz, B. and Zheng, L. and Balasubramaniyam, A. and Ham, H. and Chao, B. and Zhang, Y. and Matthews, H.F. and Cui, J. and Yao, Y. and Kubo, S. and Chanchu, J.M. and Morawski, A.R. and Cook, S.A. and Jiang, P. and Ravell, J.C. and Cheng, Y.H. and George, A. and Faruqi, A. and Pagalilauan, A.M. and Bergerson, J.R.E. and Ganesan, S. and Chauvin, S.D. and Aluri, J. and Edwards-Hicks, J. and Bohrnsen, E. and Tippett, C. and Omar, H. and Xu, L. and Butcher, G.W. and Pascall, J. and Karakoc-Aydiner, E. and Kiykim, A. and Maecker, H. and Tezcan, İ. and Esenboga, S. and Heredia, R.J. and Akata, D. and Tekin, S. and Kara, A. and Kuloglu, Z. and Unal, E. and Kendirli, T. and Dogu, F. and Karabiber, E. and Atkinson, T.P. and Cochet, C. and Filhol, O. and Bosio, C.M. and Davis, M.M. and Lifton, R.P. and Pearce, E.L. and Daumke, O. and Aytekin, C. and Şahin, G.E. and Aksu, A.Ü. and Uzel, G. and Koneti Rao, V. and Sari, S. and Boztug, K. and Cagdas, D. and Haskologlu, S. and Ikinciogullari, A. and Schwefel, D. and Vilarinho, S. and Baris, S. and Ozen, A. and Su, H.C. and Lenardo, M.J.
Nature Immunology 25 (2): 282-293. February 2024

The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
Zaupa, M. and Nagaraj, N. and Sylenko, A. and Baier, H. and Sawamiphak, S. and Filosa, A.
Neuron 30 January 2024 (In Press)

Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A. and Welters, C. and Stadler, S. and Brüggemann, M. and Dietze, K. and Brauns, O. and Brümmendorf, T.H. and Winkler, T.H. and Bullinger, L. and Blankenstein, T. and Rosenberger, L. and Leisegang, M. and Kammertöns, T. and Herr, W. and Moosmann, A. and Strobel, J. and Hackstein, H. and Dornmair, K. and Beier, F. and Hansmann, L.
Blood 28 January 2024 (In Press)

External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction.
Mehl, J. and Farahani, S.K. and Brauer, E. and Klaus-Bergmann, A. and Thiele, T. and Ellinghaus, A. and Bartels-Klein, E. and Koch, K. and Schmidt-Bleek, K. and Petersen, A. and Gerhardt, H. and Vogel, V. and Duda, G.N.
Advanced Science : e2307050. 25 January 2024 (In Press)

Efficient recovery of complete gut viral genomes by combined short- and long-read sequencing.
Chen, J. and Sun, C. and Dong, Y. and Jin, M. and Lai, S. and Jia, L. and Zhao, X. and Wang, H. and Gao, N.L. and Bork, P. and Liu, Z. and Chen, W.H. and Zhao, X.M.
Advanced Science : e2305818. 19 January 2024 (In Press)

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Hofman, D.A. and Ruiz-Orera, J. and Yannuzzi, I. and Murugesan, R. and Brown, A. and Clauser, K.R. and Condurat, A.L. and van Dinter, J.T. and Engels, S.A.G. and Goodale, A. and van der Lugt, J. and Abid, T. and Wang, L. and Zhou, K.N. and Vogelzang, J. and Ligon, K.L. and Phoenix, T.N. and Roth, J.A. and Root, D.E and Hubner, N. and Golub, T.R. and Bandopadhayay, P. and van Heesch, S. and Prensner, J.R.
Molecular Cell 84 (2): 261-276.e18. 18 January 2024

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
Uehata, T. and Yamada, S. and Ori, D. and Vandenbon, A. and Giladi, A. and Jelinski, A. and Murakawa, Y. and Watanabe, H. and Takeuchi, K. and Toratani, K. and Mino, T. and Kiryu, H. and Standley, D.M. and Tsujimura, T. and Ikawa, T. and Kondoh, G. and Landthaler, M. and Kawamoto, H. and Rodewald, H.R. and Amit, I. and Yamamoto, R. and Miyazaki, M. and Takeuchi, O.
Blood 143 (3): 243-257. 18 January 2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z. and Zhang, S. and Dupont, M. and Ragaller, F. and Sjule, E. and Cabezas-Caballero, J. and Deimel, L.P. and Robertson, H. and Russell, R.A. and Dushek, O. and Sezgin, E. and Karaji, N. and Sattentau, Q.J.
Nature Communications 15 (1): 541. 15 January 2024

Passenger gene co-amplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y. and Brame, Luca and Kirchner, M. and Fritsche-Guenther, R. and Kunz, S. and Bhattacharya, A. and Rusu, M.C. and Gürgen, D. and Dubois, F.P.B. and Köppke, J.K.C. and Proba, J. and Wittstruck, N. and Sidorova, O.A. and Chamorro González, R. and Dorado Garcia, H. and Brückner, L. and Xu, R. and Giurgiu, M. and Rodriguez-Fos, E. and Yu, Q. and Spanjaard, B. and Koche, R.P, and Schmitt, C.A. and Schulte, J.H. and Eggert, A. and Haase, K. and Kirwan, J. and Hagemann, A.I. and Mertins, P. and Dörr, J.R. and Henssen, A.G.
Cancer Discovery 13 January 2024 (In Press)

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske, Y. and Cappel, C. and Cremer, N. and Hoffmann, P. and Koudelka, T. and Tholey, A. and Heinemann, U. and Daumke, O. and Damme, M.
Nucleic Acids Research 52 (1): 370-384. 11 January 2024

Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler, F. and Ostertag, M.S. and Sommermann, T. and Weidl, D. and Sterz, K.R. and Kutz, H. and Moosmann, A. and Feller, S.M. and Geerlof, A. and Biesinger, B. and Popowicz, G.M. and Kirchmair, J. and Kieser, A.
Nature Communications 15 (1): 414. 10 January 2024

High-sensitivity cardiac troponin I enhances preeclampsia prediction beyond maternal factors and the sFlt-1/PlGF ratio.
Bacmeister, L. and Goßling, A. and Buellesbach, A. and Birukov, A. and Myers, J.E. and Thomas, S.T. and Lee, S. and Andersen, M.S. and Jorgensen, J.S. and Diemert, A. and Blois, S.M. and Arck, P.C. and Hecher, K. and Herse, F. and Blankenberg, S. and Dechend, R. and Westermann, D. and Zeller, T.
Circulation 149 (2): 95-106. 9 January 2024

CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D. and Zschummel, M. and Bunse, M. and Rousselle, A. and Sonnemann, J. and Kettritz, R. and Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 5 January 2024 (In Press)

SPIRE: a Searchable, Planetary-scale mIcrobiome REsource.
Schmidt, T.S.B. and Fullam, A. and Ferretti, P. and Orakov, A. and Maistrenko, O.M. and Ruscheweyh, H.J. and Letunic, I. and Duan, Y. and Van Rossum, T. and Sunagawa, S. and Mende, D.R. and Finn, R.D. and Kuhn, M. and Pedro Coelho, L. and Bork, P.
Nucleic Acids Research 52 (D1): D777-D783. 5 January 2024

Cortical matrix remodeling as a hallmark of relapsing-remitting neuroinflammation in MR elastography and quantitative MRI.
Silva, R.V. and Morr, A.S. and Herthum, H. and Koch, S.P. and Mueller, S. and Batzdorf, C.S. and Bertalan, G. and Meyer, T. and Tzschätzsch, H. and Kühl, A.A. and Boehm-Sturm, P. and Braun, J. and Scheel, M. and Paul, F. and Infante-Duarte, C. and Sack, I.
Acta Neuropathologica 147 (1): 8. 4 January 2024

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.
Borsa, M. and Obba, S. and Richter, F.C. and Zhang, H. and Riffelmacher, T. and Carrelha, J. and Alsaleh, G. and Jacobsen, S.E.W. and Simon, A.K.
Autophagy 20 (1): 45-57. January 2024

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.
Bruedigam, C. and Porter, A.H. and Song, A. and Vroeg In de Wei, G. and Stoll, T. and Straube, J. and Cooper, L. and Cheng, G. and Kahl, V.F.S. and Sobinoff, A.P. and Ling, V.Y. and Jebaraj, B.M.C. and Janardhanan, Y. and Haldar, R. and Bray, L.J. and Bullinger, L. and Heidel, F.H. and Kennedy, G.A. and Hill, M.M. and Pickett, H.A. and Abdel-Wahab, O. and Hartel, G. and Lane, S.W.
Nature Cancer 5 (1): 47-65. January 2024

Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease.
Essex, M. and Rios Rodriguez, V. and Rademacher, J. and Proft, F. and Löber, U. and Marko, L. and Pleyer, U. and Strowig, T. and Marchand, J. and Kirwan, J.A. and Siegmund, B. and Forslund, S.K. and Poddubnyy, D.
Arthritis & Rheumatology 76 (1): 48-58. January 2024

Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Mueller-Calleja, N. and Grunz, K. and Nguyen, T.S. and Posma, J. and Pedrosa, D. and Meineck, M. and Hollerbach, A. and Braun, J. and Muth, S. and Schild, H. and Saar, K. and Hübner, N. and Krishnaswamy, S. and Royce, J. and Teyton, L. and Lemmermann, N.A. and Weinmann-Menke, J. and Lackner, K.J. and Ruf, W.
Blood 27 December 2023 (In Press)

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A. and Lahmann, I. and Nguyen, L.V.N. and Rost, B.R. and García-Pérez, A. and Lelievre, N. and Merritt-Garza, M.E. and Phan, H.C and Bassell, G.J. and Rossoll, W. and Diecke, S. and Kunz, S. and Schmitz, D. and Gouti, M.
Nature Communications 14 (1): 8043. 19 December 2023

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Wang, Z. and Shaabani, S. and Gao, X. and Ng, Y.L.D. and Sapozhnikova, V. and Mertins, P. and Krönke, J. and Dömling, A.
Nature Communications 14 (1): 8437. 19 December 2023

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk, M.C. and Gleixner, J.G. and Heigwer, F. and Vonficht, D. and Valentini, E. and Aydin, Z. and Tonin, E. and Del Prete, S. and Mahara, S. and Throm, Y. and Hetzer, J. and Heide, D. and Stegle, O. and Odom, D.T. and Feldmann, A. and Haas, S. and Heikenwalder, M. and Boutros, M.
Developmental Cell 58 (24): 2914-2929. 18 December 2023

Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
Smolgovsky, S. and Bayer, A.L. and Kaur, K. and Sanders, E. and Aronovitz, M. and Filipp, M.E. and Thorp, E.B. and Schiattarella, G.G. and Hill, J.A. and Blanton, R.M. and Cubillos-Ruiz, J.R. and Alcaide, P.
Journal of Clinical Investigation 133 (24): e171874. 15 December 2023

Autoantibodies against the chemokine receptor 3 predict cardiovascular risk.
Müller, F.S. and Aherrahrou, Z. and Grasshoff, H. and Heidorn, M.W. and Humrich, J.Y. and Johanson, L. and Aherrahrou, R. and Reinberger, T. and Schulz, A. and Ten Cate, V. and Robles, A.P. and Koeck, T. and Rapp, S. and Lange, T. and Brachaczek, L. and Luebber, F. and Erdmann, J. and Heidecke, H. and Schulze-Forster, K. and Dechend, R. and Lackner, K.J. and Pfeiffer, N. and Ghaemi Kerahrodi, J. and Tüscher, O. and Schwarting, A. and Strauch, K. and Münzel, T. and Prochaska, J.H. and Riemekasten, G. and Wild, P.S.
European Heart Journal 44 (47): 4935-4949. 14 December 2023

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.
Müller, P. and de la Cuesta-Zuluaga, J. and Kuhn, M. and Baghai Arassi, M. and Treis, T. and Blasche, S. and Zimmermann, M. and Bork, P. and Patil, K.R. and Typas, A. and Garcia-Santamarina, S. and Maier, L.
Nature Protocols 13 December 2023 (In Press)

RIF1 regulates early replication timing in murine B cells.
Malzl, D. and Peycheva, M. and Rahjouei, A. and Gnan, S. and Klein, K.N. and Nazarova, M. and Schoeberl, U.E. and Gilbert, D.M. and Buonomo, S.C.B. and Di Virgilio, M. and Neumann, T. and Pavri, R.
Nature Communications 14 (1): 8049. 11 December 2023

Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022.
Baumgartner, F. and Baer, C. and Bamopoulos, S.A. and Ayoub, E. and Truger, M. and Meggendorfer, M. and Lenk, M. and Hoermann, G. and Hutter, S. and Müller, H. and Walter, W. and Mueller, M.L. and Nadarajah, Ni. and Blombery, P. and Keller, U. and Kern, W. and Haferlach, C. and Haferlach, T.
Blood 8 December 2023 (In Press)

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.
Dönig, J. and Mende, H. and Davila Gallesio, J. and Wagner, K. and Hotz, P. and Schunck, K. and Piller, T. and Hölper, S. and Uhan, S. and Kaulich, M. and Wirth, M. and Keller, U. and Tascher, G. and Bohnsack, K.E. and Müller, S.
Nature Communications 14 (1): 8121. 8 December 2023

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.
Ilia, K. and Shakiba, N. and Bingham, T. and Jones, R.D. and Kaminski, M.M. and Aravera, E. and Bruno, S. and Palacios, S. and Weiss, R. and Collins, J.J. and Del Vecchio, D. and Schlaeger, T.M.
Science Advances 9 (48): eadg8495. December 2023

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J. and Theisen, S. and Dartsch, J. and Fritsche-Guenther, R. and Kirchner, M. and Obermayer, B. and Bauer, A. and Kahlert, A.K. and Rothe, M. and Beule, D. and Heuser, A. and Mertins, P. and Kirwan, J.A. and Berndt, N. and MacRae, C.A. and Hubner, N. and Klaassen, S.
Cardiovascular Research 119 (18): 2902-2916. December 2023

Insm1 regulates mTEC development and immune tolerance.
Tao, W. and Ye, Z. and Wei, Y. and Wang, J. and Yang, W. and Yu, G. and Xiong, J. and Jia, S.
Cellular and Molecular Immunology 20 (12): 1472-1486. December 2023

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
Benedum, J. and Franke, V. and Appel, L.M. and Walch, L. and Bruno, M. and Schneeweiss, R. and Gruber, J. and Oberndorfer, H. and Frank, E. and Strobl, X. and Polyansky, A. and Zagrovic, B. and Akalin, A. and Slade, D.
Nature Communications 14 (1): 7912. 30 November 2023

Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases.
Wang, M. and Dehlinger, A. and Fernández Zapata, C. and Golan, M. and Gallaccio, G. and Sander, L.E. and Schlickeiser, S. and Kunkel, D. and Schmitz-Hübsch, T. and Sawitzki, B. and Karni, A. and Braun, J. and Loyal, L. and Thiel, A. and Bellmann-Strobl, J. and Paul, F. and Meyer-Arndt, L. and Boettcher, C.
Nature Communications 14 (1): 7728. 25 November 2023

Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages.
Apaydin, O. and Altaikyzy, A. and Filosa, A. and Sawamiphak, S.
Developmental Cell 58 (22): 2460-2476.e7. 20 November 2023

Latent human herpesvirus 6 is reactivated in CAR T cells.
Lareau, C.A. and Yin, Y. and Maurer, K. and Sandor, K.D. and Daniel, B. and Yagnik, G. and Peña, J. and Crawford, J.C. and Spanjaart, A.M. and Gutierrez, J.C. and Haradhvala, N.J. and Riberdy, J.M. and Abay, T. and Stickels, R.R. and Verboon, J.M. and Liu, V. and Buquicchio, F.A. and Wang, F. and Southard, J. and Song, R. and Li, W. and Shrestha, A. and Parida, L. and Getz, G. and Maus, M.V. and Li, S. and Moore, A. and Roberts, Z.J. and Ludwig, L.S. and Talleur, A.C. and Thomas, P.G. and Dehghani, H. and Pertel, T. and Kundaje, A. and Gottschalk, S. and Roth, T.L. and Kersten, M.J. and Wu, C.J. and Majzner, R.G. and Satpathy, A.T.
Nature 623 : 608-615. 16 November 2023

IL-33 expression is lower in current smokers at both transcriptomic and protein level.
Faiz, A. and Mahbub, R.M. and Boedijono, F.S. and Tomassen, M.I. and Kooistra, W. and Timens, W. and Nawijn, M. and Hansbro, P.M. and Johansen, M.D. and Pouwels, S.D. and Heijink, I.H. and Massip, F. and de Biase, M.S. and Schwarz, R.F. and Adcock, I.M. and Chung, K.F. and van der Does, A. and Hiemstra, P.S. and Goulaouic, H. and Xing, H. and Abdulai, R. and de Rinaldis, E. and Cunoosamy, D. and Harel, S. and Lederer, D. and Nivens, M.C. and Wark, P.A. and Kerstjens, H.A.M. and Hylkema, M.N. and Brandsma, C.A. and van den Berge, M.
American Journal of Respiratory and Critical Care Medicine 208 (10): 1075-1087. 15 November 2023

Lipid nanoparticle-mediated hit-and-run approaches yield efficient and safe in situ gene editing in human skin.
Bolsoni, J. and Liu, D. and Mohabatpour, F. and Ebner, R. and Sadhnani, G. and Tafech, B. and Leung, J. and Shanta, S. and An, K. and Morin, T. and Chen, Y. and Arguello, A. and Choate, K. and Jan, E. and Ross, C.J.D. and Brambilla, D. and Witzigmann, D. and Kulkarni, J. and Cullis, P.R. and Hedtrich, S.
ACS Nano 17 (21): 22046-22059. 14 November 2023

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
Chatzinikolaou, G. and Stratigi, K. and Siametis, A. and Goulielmaki, E. and Akalestou-Clocher, A. and Tsamardinos, I. and Topalis, P. and Austin, C. and Bouwman, B.A.M. and Crosetto, N. and Altmüller, J. and Garinis, G.A.
Science Advances 9 (45): eadi2095. 10 November 2023

Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
Reincke, S.M. and von Wardenburg, N. and Homeyer, M.A. and Kornau, H.C. and Spagni, G. and Li, L.Y. and Kreye, J. and Sánchez-Sendín, E. and Blumenau, S. and Stappert, D. and Radbruch, H. and Hauser, A.E. and Künkele, A. and Edes, I. and Schmitz, D. and Prüss, H.
Cell 186 (23): 5084-5097.e18. 9 November 2023

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma.
Finotto, L. and Cole, B. and Giese, W. and Baumann, E. and Claeys, A. and Vanmechelen, M. and Decraene, B. and Derweduwe, M. and Dubroja Lakic, N. and Shankar, G. and Nagathihalli Kantharaju, M. and Albrecht, J.P. and Geudens, I. and Stanchi, F. and Ligon, K.L. and Boeckx, B. and Lambrechts, D. and Harrington, K. and Van Den Bosch, L. and De Vleeschouwer, S. and De Smet, F. and Gerhardt, H.
EMBO Molecular Medicine 15 (11): e18144. 8 November 2023

Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N. and Cauchy, P. and Franke, V. and Giefing, M. and Fornes, O. and Vankadari, N. and Assi, S.A. and Costanza, M. and Weniger, M.A. and Akalin, A. and Anagnostopoulos, I. and Bukur, T. and Casarotto, M.G. and Damm, F. and Daumke, O. and Edginton-White, B. and Gebhardt, J.C.M. and Grau, M. and Grunwald, S. and Hansmann, M.L. and Hartmann, S. and Huber, L. and Kärgel, E. and Lusatis, S. and Noerenberg, D. and Obier, N. and Pannicke, U. and Fischer, A. and Reisser, A. and Rosenwald, A. and Schwarz, K. and Sundararaj, S. and Weilemann, A. and Winkler, W. and Xu, W. and Lenz, G. and Rajewsky, K. and Wasserman, W.W. and Cockerill, P.N. and Scheidereit, C. and Siebert, R. and Küppers, R. and Grosschedl, R. and Janz, M. and Bonifer, C. and Mathas, S.
Nature Communications 14 (1): 6947. 7 November 2023

Leveraging large language models for decision support in personalized oncology.
Benary, M. and Wang, X.D. and Schmidt, M. and Soll, D. and Hilfenhaus, G. and Nassir, M. and Sigler, C. and Knödler, M. and Keller, U. and Beule, D. and Keilholz, U. and Leser, U. and Rieke, D.T.
JAMA Network Open 6 (11): e2343689. November 2023

Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F. and Noerenberg, D. and Hennch, C. and Yoshida, K. and Hablesreiter, R. and Nimo, J. and Sasca, D. and Kirchner, M. and Mansouri, L. and Inoue, Y. and Wiegand, L. and Staiger, A.M. and Casadei, B. and Korkolopoulou, P. and Weiner, J. and Lopez-Guillermo, A. and Warth, A. and Schneider, T. and Nagy, Á. and Klapper, W. and Hummel, M. and Kanellis, G. and Anagnostopoulos, I. and Mertins, P. and Bullinger, L. and Rosenquist, R. and Vassilakopoulos, T.P. and Ott, G. and Ogawa, S. and Damm, F.
Leukemia 37 (11): 2237-2249. November 2023

Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients.
Jahn, E. and Saadati, M. and Fenaux, P. and Gobbi, M. and Roboz, G.J. and Bullinger, L. and Lutsik, P. and Riedel, A. and Plass, C. and Jahn, N. and Walter, C. and Holzmann, K. and Hao, Y. and Naim, S. and Schreck, N. and Krzykalla, J. and Benner, A. and Keer, H.N. and Azab, M. and Döhner, K. and Döhner, H.
Leukemia 37 (11): 2187-2196. November 2023

Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
Nikopoulou, C. and Kleinenkuhnen, N. and Parekh, S. and Sandoval, T. and Ziegenhain, C. and Schneider, F. and Giavalisco, P. and Donahue, K.F. and Vesting, A.J. and Kirchner, M. and Bozukova, M. and Vossen, C. and Altmüller, J. and Wunderlich, T. and Sandberg, R. and Kondylis, V. and Tresch, A. and Tessarz, P.
Nature Aging 3 (11): 1430-1445. November 2023

Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine - a prospective cohort study by the AGMT.
Pleyer, L. and Vaisband, M. and Drost, M. and Pfeilstöcker, M. and Stauder, R. and Heibl, S. and Sill, H. and Girschikofsky, M. and Stampfl-Mattersberger, M. and Pichler, A. and Hartmann, B. and Petzer, A. and Schreder, M. and Schmitt, C.A. and Vallet, S. and Melchardt, T. and Zebisch, A. and Pichler, P. and Zaborsky, N. and Machherndl-Spandl, S. and Wolf, D. and Keil, F. and Hasenauer, J. and Larcher-Senn, J. and Greil, R.
American Journal of Hematology 98 (11): 1685-1698. November 2023

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li, X. and Wu, F. and Günther, S. and Looso, M. and Kuenne, C. and Zhang, T. and Wiesnet, M. and Klatt, S. and Zukunft, S. and Fleming, I. and Poschet, G. and Wietelmann, A. and Atzberger, A. and Potente, M. and Yuan, X. and Braun, T.
Nature 622 (7983): 619-626. 19 October 2023

Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N. and Yushkevich, A. and Mikirtumov, V. and Sanchez, R.M. and Sprink, T. and Kudryashev, M.
Nature Communications 14 (1): 6543. 17 October 2023

Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B. and Zhang, S. and Polovitskaya, M.M. and Yi, J. and Ye, B. and Li, R. and Huang, X. and Yin, J. and Neuens, S. and Balfroid, T. and Soblet, J. and Vens, D. and Aeby, A. and Li, X. and Cai, J. and Song, Y. and Li, Y. and Tartaglia, M. and Li, Y. and Jentsch, T.J. and Yang, M. and Liu, Z.
Science Advances 9 (41): eadg4479. 13 October 2023

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
Nurminen, A. and Jaatinen, S. and Taavitsainen, S. and Högnäs, G. and Lesluyes, T. and Ansari-Pour, N. and Tolonen, T. and Haase, K. and Koskenalho, A. and Kankainen, M. and Jasu, J. and Rauhala, H. and Kesäniemi, J. and Nikupaavola, T. and Kujala, P. and Rinta-Kiikka, I. and Riikonen, J. and Kaipia, A. and Murtola, T. and Tammela, T.L. and Visakorpi, T. and Nykter, M. and Wedge, D.C. and Van Loo, P. and Bova, G.S.
Genome Medicine 15 (1): 82. 12 October 2023

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S. and Lucht, M.T. and Petzoldt, A. and Kong, S. and Sun, J. and Vines, J.H. and Telugu, N.S. and Diecke, S. and Kaas, T. and Bullmann, T. and Schmied, C. and Löwe, D. and King, J.S. and Cho, W. and Hallermann, S. and Puchkov, D. and Sigrist, S.J. and Haucke, V.
Science 382 (6667): 223-230. 12 October 2023

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A. and Kilanowski, A. and Sobczyk, M.K. and Shringarpure, S.S. and Mitchell, R. and Reis, K. and Reigo, A. and Mägi, R. and Nelis, M. and Tanaka, N. and Brumpton, B.M. and Thomas, L.F. and Sole-Navais, P. and Flatley, C. and Espuela-Ortiz, A. and Herrera-Luis, E. and Lominchar, J.V.T. and Bork-Jensen, J. and Marenholz, I. and Arnau-Soler, A. and Jeong, A. and Fawcett, K.A. and Baurecht, H. and Rodriguez, E. and Alves, A.C. and Kumar, A. and Sleiman, P.M. and Chang, X. and Medina-Gomez, C. and Hu, C. and Xu, C.J. and Qi, C. and El-Heis, S. and Titcombe, P. and Antoun, E. and Fadista, J. and Wang, C.A. and Thiering, E. and Wu, B. and Kress, S. and Kothalawala, D.M. and Kadalayil, L. and Duan, J. and Zhang, H. and Hadebe, S. and Hoffmann, T. and Jorgenson, E. and Choquet, H. and Risch, N. and Njølstad, P. and Andreassen, O.A. and Johansson, S. and Almqvist, C. and Gong, T. and Ullemar, V. and Karlsson, R. and Magnusson, P.K.E. and Szwajda, A. and Burchard, E.G. and Thyssen, J.P. and Hansen, T. and Kårhus, L.L. and Dantoft, T.M. and Jeanrenaud, A.C.S.N. and Ghauri, A. and Arnold, A. and Homuth, G. and Lau, S. and Nöthen, M.M. and Hübner, N. and Imboden, M. and Visconti, A. and Falchi, M. and Bataille, V. and Hysi, P. and Ballardini, N. and Boomsma, D.I. and Hottenga, J.J. and Müller-Nurasyid, M. and Ahluwalia, T.S. and Stokholm, J. and Chawes, B. and Schoos, A.M.M. and Esplugues, A. and Bustamante, M. and Raby, B. and Arshad, S. and German, C. and Esko, T. and Milani, L.A. and Metspalu, A. and Terao, C. and Abuabara, K. and Løset, M. and Hveem, K. and Jacobsson, B. and Pino-Yanes, M. and Strachan, D.P. and Grarup, N. and Linneberg, A. and Lee, Y. and Probst-Hensch, N. and Weidinger, S. and Jarvelin, M.R. and Melén, E. and Hakonarson, H. and Irvine, A.D. and Jarvis, D. and Nijsten, T. and Duijts, L. and Vonk, J.M. and Koppelmann, G.H. and Godfrey, K.M. and Barton, S.J. and Feenstra, B. and Pennell, C.E. and Sly, P.D. and Holt, P.G. and Williams, L.K. and Bisgaard, H. and Bønnelykke, K. and Curtin, J. and Simpson, A. and Murray, C. and Schikowski, T. and Bunyavanich, S. and Weiss, S.T. and Holloway, J.W. and Min, J.L. and Brown, S.J. and Standl, M. and Paternoster, L.
Nature Communications 14 (1): 6172. 4 October 2023

Play and tickling responses map to the lateral columns of the rat periaqueductal gray.
Gloveli, N. and Simonnet, J. and Tang, W. and Concha-Miranda, M. and Maier, E. and Dvorzhak, A. and Schmitz, D. and Brecht, M.
Neuron 111 (19): 3041-3052. 4 October 2023

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T. and Stolzenberg, S. and Sticht, J. and Wieczorek, M. and Roske, Y. and Günther, M. and Dähn, S. and Boesen, B.B. and Calvo, M.M. and Biese, C. and Kuppler, F. and Medina-García, Á. and Álvaro-Benito, M. and Höfer, T. and Noé, F. and Freund, C.
Nature Chemical Biology 19 (10): 1196-1204. October 2023

Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Eifert, T. and Hsu, C.J. and Becker, A.L. and Graessle, S. and Horne, A. and Bemmann, F. and Zhang, Q. and Heuser, M. and Vasioukhin, V. and Scholl, S. and Hochhaus, A. and Siegerist, F. and Endlich, N. and Bullinger, L. and Lane, S.W. and Haas, S. and Schnoeder, T.M and Heidel, F.H.
Leukemia 37 (10): 2027-2035. October 2023

Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial.
Gold, S.M. and Friede, T. and Meyer, B. and Moss-Morris, R. and Hudson, J. and Asseyer, S. and Bellmann-Strobl, J. and Leisdon, A. and Ißels, L. and Ritter, K. and Schymainski, D. and Pomeroy, H. and Lynch, S.G. and Cozart, J.S. and Thelen, J. and Román, C.A.F. and Cadden, M. and Guty, E. and Lau, S. and Pöttgen, J. and Ramien, C. and Seddiq-Zai, S. and Kloidt, A.M. and Wieditz, J. and Penner, I.K. and Paul, F. and Sicotte, N.L. and Bruce, J.M. and Arnett, P.A. and Heesen, C.
Lancet Digital Health 5 (10): e668-e678. October 2023

Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I. and Emmenegger, L. and Zappulo, A. and Rybak-Wolf, A. and Wurmus, R. and Oliveras Martinez, A. and Cerda Jara, C. and Boltengagen, A. and Hessler, T. and Mastrobuoni, G. and Kempa, S. and Zinzen, R. and Woehler, A. and Rajewsky, N.
Nature Methods 20 (10): 1544-1552. October 2023

Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.
Cui, L. and Yang, B. and Xiao, S. and Gao, J. and Baud, A. and Graham, D. and McBride, M. and Dominiczak, A. and Schafer, S. and Aumatell, R.L. and Mont, C. and Teruel, A.F. and Hübner, N. and Flint, J. and Mott, R. and Huang, L.
Genome Biology 24 (1): 215. 29 September 2023

HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.
Welters, C. and Welters, M.L. and Stadler, S. and Bullinger, L. and Strobel, J. and Hackstein, H. and Dhamodaran, A. and Blankenstein, T. and Hansmann, L.
Haematologica 28 September 2023 (In Press)

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
Rejeski, K. and Perez, A. and Iacoboni, G. and Blumenberg, V. and Bücklein, V.L. and Völkl, S. and Penack, O. and Albanyan, O. and Stock, S. and Müller, F. and Karschnia, P. and Petrera, A. and Reid, K. and Faramand, R. and Davila, M.L. and Modi, K. and Dean, E.A. and Bachmeier, C. and von Bergwelt-Baildon, M. and Locke, F.L. and Bethge, W. and Bullinger, L. and Mackensen, A. and Barba, P. and Jain, M.D. and Subklewe, M.
Science Advances 9 (38): eadg3919. 22 September 2023

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P. and Aron-Wisnewsky, J. and Chakaroun, R. and Myridakis, A. and Forslund, S.K. and Nielsen, T. and Adriouch, S. and Holmes, B. and Chilloux, J. and Vieira-Silva, S. and Falony, G. and Salem, J.E. and Andreelli, F. and Belda, E. and Kieswich, J. and Chechi, K. and Puig-Castellvi, F. and Chevalier, M. and Le Chatelier, E. and Olanipekun, M.T. and Hoyles, L. and Alves, R. and Helft, G. and Isnard, R. and Køber, L. and Coelho, L.P. and Rouault, C. and Gauguier, D. and Gøtze, J.P. and Prifti, E. and Froguel, P. and Zucker, J.D. and Bäckhed, F. and Vestergaard, H. and Hansen, T. and Oppert, J.M. and Blüher, M. and Nielsen, J. and Raes, J. and Bork, P. and Yaqoob, M.M. and Stumvoll, M. and Pedersen, O. and Ehrlich, S.D. and Clément, K. and Dumas, M.E.
Nature Communications 14 (1): 5843. 20 September 2023

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K. and Ginggen, K. and Ivanov, A. and Buckinx, A. and Lalive, A.L. and Tchenio, A. and Benson, S. and Vendrell, M. and D'Alessandro, A. and Beule, D. and Pellerin, L. and Mameli, M. and Paolicelli, R.C.
Nature Communications 14 (1): 5749. 16 September 2023

Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases.
Sun, C. and Chen, J. and Jin, M. and Zhao, X. and Li, Y. and Dong, Y. and Gao, N. and Liu, Z. and Bork, P. and Zhao, X.M. and Chen, W.H.
Advanced Science 10 (25): 2302159. 5 September 2023

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.
Schoeler, M. and Ellero-Simatos, S. and Birkner, T. and Mayneris-Perxachs, J. and Olsson, L. and Brolin, H. and Löber, U. and Kraft, J.D. and Polizzi, A. and Martí-Navas, M. and Puig, J. and Moschetta, A. and Montagner, A. and Gourdy, P. and Heymes, C. and Guillou, H. and Tremaroli, V. and Fernández-Real, J.M. and Forslund, S.K. and Burcelin, R. and Caesar, R.
Nature Communications 14 (1): 5329. 1 September 2023

Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire.
Anker, M.S. and Potthoff, S.K. and Lena, A. and Porthun, J. and Hadzibegovic, S. and Evertz, R. and Denecke, C. and Fröhlich, A.K. and Sonntag, F. and Regitz-Zagrosek, V. and Rosen, S.D. and Lyon, A.R. and Lüscher, T.F. and Spertus, J.A. and Anker, S.D. and Karakas, M. and Bullinger, L. and Keller, U. and Landmesser, U. and Butler, J. and von Haehling, S.
European Journal of Heart Failure 25 (9): 1635-1647. September 2023

Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.
Zhang, L. and Wirth, M. and Patra, U. and Stroh, J. and Isaakidis, K. and Rieger, L. and Kossatz, S. and Milanovic, M. and Zang, C. and Demel, U. and Keiten-Schmitz, J. and Wagner, K. and Steiger, K. and Rad, R. and Bassermann, F. and Müller, S. and Keller, U. and Schick, M.
EMBO Molecular Medicine 15 (9): e16431. September 2023

Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.
Tschernoster, N. and Erger, F. and Kohl, S. and Reusch, B. and Wenzel, A. and Walsh, S. and Thiele, H. and Becker, C. and Franitza, M. and Bartram, M.P. and Kömhoff, M. and Schumacher, L. and Kukat, C. and Borodina, T. and Quedenau, C. and Nürnberg, P. and Rinschen, M.M. and Driller, J.H. and Pedersen, B.P. and Schlingmann, K.P. and Hüttel, B. and Bockenhauer, D. and Beck, B. and Altmüller, J.
Genome Medicine 15 (1): 62. 23 August 2023

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A. and Latorre, J. and Serena-Maione, A. and Espadas, I. and Caballano-Infantes, E. and Moreno-Navarrete, J.M. and Oliveras-Cañellas, N. and Ricart, W. and Malagón, M.M. and Martin-Montalvo, A. and Birchmeier, W. and Szymanski, W. and Graumann, J. and Gómez-Serrano, M. and Sommariva, E. and Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14 (1): 5106. 22 August 2023

Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort.
Legler, F. and Meyer-Arndt, L. and Mödl, L. and Kedor, C. and Freitag, H. and Stein, E. and Hoppmann, U. and Rust, R. and Wittke, K. and Siebert, N. and Behrens, J. and Thiel, A. and Konietschke, F. and Paul, F. and Scheibenbogen, C. and Bellmann-Strobl, J.
EClinicalMedicine 63 : 102146. 19 August 2023

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
John, L. and Poos, A.M. and Brobeil, A. and Schinke, C. and Huhn, S. and Prokoph, N. and Lutz, R. and Wagner, B. and Zangari, M. and Tirier, S.M. and Mallm, J.P. and Schumacher, S. and Vonficht, D. and Solé-Boldo, L. and Quick, S. and Steiger, S. and Przybilla, M.J. and Bauer, K. and Baumann, A. and Hemmer, S. and Rehnitz, C. and Lückerath, C. and Sachpekidis, C. and Mechtersheimer, G. and Haberkorn, U. and Dimitrakopoulou-Strauss, A. and Reichert, P. and Barlogie, B. and Müller-Tidow, C. and Goldschmidt, H. and Hillengass, J. and Rasche, L. and Haas, S.F. and van Rhee, F. and Rippe, K. and Raab, M.S. and Sauer, S. and Weinhold, N.
Nature Communications 14 (1): 5011. 17 August 2023

Enterotypes of the human gut mycobiome.
Lai, S. and Yan, Y. and Pu, Y. and Lin, S. and Qiu, J.G. and Jiang, B.H. and Keller, M.I. and Wang, M. and Bork, P. and Chen, W.H. and Zheng, Y. and Zhao, X.M.
Microbiome 11 (1): 179. 11 August 2023

Systematic benchmarking of single-cell ATAC-sequencing protocols.
De Rop, F.V. and Hulselmans, G. and Flerin, C. and Soler-Vila, P. and Rafels, A. and Christiaens, V. and González-Blas, C.B. and Marchese, D. and Caratù, G. and Poovathingal, S. and Rozenblatt-Rosen, O. and Slyper, M. and Luo, W. and Muus, C. and Duarte, F. and Shrestha, R. and Bagdatli, S.T. and Corces, M.R. and Mamanova, L. and Knights, A. and Meyer, K.B. and Mulqueen, R. and Taherinasab, A. and Maschmeyer, P. and Pezoldt, J. and Lambert, C.L.G. and Iglesias, M. and Najle, S.R. and Dossani, Z.Y. and Martelotto, L.G. and Burkett, Z. and Lebofsky, R. and Martin-Subero, J.I. and Pillai, S. and Sebé-Pedrós, A. and Deplancke, B. and Teichmann, S.A. and Ludwig, L.S. and Braun, T.P. and Adey, A.C. and Greenleaf, W.J. and Buenrostro, J.D. and Regev, A. and Aerts, S. and Heyn, H.
Nature Biotechnology 3 August 2023 (In Press)

mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons.
Loedige, I. and Baranovskii, A. and Mendonsa, S. and Dantsuji, S. and Popitsch, N. and Breimann, L. and Zerna, N. and Cherepanov, V. and Milek, M. and Ameres, S. and Chekulaeva, M.
Molecular Cell 83 (15): 2709-2725. 3 August 2023

Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering.
Liu, C.C. and Greenwald, N.F. and Kong, A. and McCaffrey, E.F. and Leow, K.X. and Mrdjen, D. and Cannon, B.J. and Rumberger, J.L. and Varra, S.R. and Angelo, M.
Nature Communications 14 (1): 4618. 1 August 2023

Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
Schaupp, L. and Addante, A. and Völler, M. and Fentker, K. and Kuppe, A. and Bardua, M. and Duerr, J. and Piehler, L. and Röhmel, J. and Thee, S. and Kirchner, M. and Ziehm, M. and Lauster, D. and Haag, R. and Gradzielski, M. and Stahl, M. and Mertins, P. and Boutin, S. and Graeber, S.Y. and Mall, M.A.
European Respiratory Journal 62 (2): 2202153. 1 August 2023

Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia.
Kayser, S. and Martínez-Cuadrón, D. and Rodriguez-Veiga, R. and Hänel, M. and Tormo, M. and Schäfer-Eckart, K. and Botella, C. and Stölzel, F. and Del Castillo, T.B. and Keller, U. and Rodriguez-Medina, C. and Held, G. and Amigo, M.L. and Schliemann, C. and Colorado, M. and Kaufmann, M. and Garcia, M.B. and Krause, S.W. and Görner, M. and Jost, E. and Steffen, B. and Zukunft, S. and Platzbecker, U. and Ho, A.D. and Baldus, C.D. and Serve, H. and Müller-Tidow, C. and Thiede, C. and Bornhäuser, M. and Montesinos, P. and Röllig, C. and Schlenk, R.F.
Haematologica 108 (8): 2059-2066. August 2023

Intravenous immunoglobulin treatment for acute attacks in myelin oligodendrocyte glycoprotein antibody disease.
Lotan, I. and Chen, J.J. and Hacohen, Y. and Abdel-Mannan, O. and Mariotto, S. and Huda, S. and Gibbons, E. and Wilf-Yarkoni, A. and Hellmann, M.A. and Stiebel-Kalish, H. and Pittock, S.J. and Flanagan, E.P. and Molazadeh, N. and Anderson, M. and Salky, R. and Romanow, G. and Schindler, P. and Duchow, A.S. and Paul, F. and Levy, M.
Multiple Sclerosis Journal 29 (9): 1080-1089. August 2023

Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury.
Sanad, A.M. and Qadri, F. and Popova, E. and Rodrigues, A.F. and Heinbokel, T. and Quach, S. and Schulz, A. and Bachmann, S. and Kreutz, R. and Alenina, N. and Bader, M.
Kidney International 104 (2): 293-304. August 2023

Spatially resolved multiomics of human cardiac niches.
Kanemaru, K. and Cranley, J. and Muraro, D. and Miranda, A.M.A. and Ho, S.Y. and Wilbrey-Clark, A. and Patrick Pett, J. and Polanski, K. and Richardson, L. and Litvinukova, M. and Kumasaka, R. and Qin, Y. and Jablonska, Z. and Semprich, C.I. and Mach, L. and Dabrowska, M. and Richoz, R. and Bolt, L. and Mamanova, L. and Kapuge, R. and Barnett, S.N. and Perera, S. and Talavera-López, C. and Mulas, I. and Mahbubani, K.T. and Tuck, Liz and Wang, Lu and Huang, M.M. and Prete, M. and Pritchard, S. and Dark, J. and Saeb-Parsy, K. and Patel, M. and Clatworthy, M.R. and Hübner, N. and Chowdhury, R.A. and Noseda, M. and Teichmann, S.A.
Nature 619 : 801-810. 27 July 2023

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.
Schubert, M.L. and Schmitt, A. and Hückelhoven-Krauss, A. and Neuber, B. and Kunz, A. and Waldhoff, P. and Vonficht, D. and Yousefian, S. and Jopp-Saile, L. and Wang, L. and Korell, F. and Keib, A. and Michels, B. and Haas, D. and Sauer, T. and Derigs, P. and Kulozik, A. and Kunz, J. and Pavel, P. and Laier, S. and Wuchter, P. and Schmier, J. and Bug, G. and Lang, F. and Gökbuget, N. and Casper, J. and Görner, M. and Finke, J. and Neubauer, A. and Ringhoffer, M. and Wolleschak, D. and Brüggemann, M. and Haas, S. and Ho, A.D. and Müller-Tidow, C. and Dreger, P. and Schmitt, M.
Journal of Hematology & Oncology 16 (1): 79. 22 July 2023

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
Ziegler, K.A. and Ahles, A. and Dueck, A. and Esfandyari, D. and Pichler, P. and Weber, K. and Kotschi, S. and Bartelt, A. and Sinicina, I. and Graw, M. and Leonhardt, H. and Weckbach, L.T. and Massberg, S. and Schifferer, M. and Simons, M. and Hoeher, L. and Luo, J. and Ertürk, A. and Schiattarella, G.G. and Sassi, Y. and Misgeld, T. and Engelhardt, S.
Science 381 (6655): 285-290. 21 July 2023

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A. and Haenig, C. and Neuendorf, N. and Blanc, E. and Ivanov, A. and Kirchner, M. and Schleumann, P. and Bayraktaroğlu, I. and Richter, M. and Molenda, C.M. and Sporbert, A. and Zenkner, M. and Schnoegl, S. and Suenkel, C. and Schneider, L.S. and Rybak-Wolf, A. and Kochnowsky, B. and Byrne, L.M. and Wild, E.J. and Nielsen, J.E. and Dittmar, G. and Peters, O. and Beule, D. and Wanker, E.E.
Genome Medicine 15 (1): 50. 20 July 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D. and Ruffault, P.L. and Misios, A. and Osman, K.L. and Li, H. and Greenberg, R.S. and Thompson, R. and Song, K. and Dietrich, S. and Li, X. and Vladimirov, N. and Woehler, A. and Brunet, J.F. and Zampieri, N. and Kühn, R. and Liberles, S.D. and Jia, S. and Lewin, G.R. and Rajewsky, N. and Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J. and Rodríguez-Martínez, M. and Fenzl, K. and Hinze, F. and Schraivogel, D. and Grosch, M. and Tunaj, B. and Lindenhofer, D. and Schraft, L. and Kueblbeck, M. and Smith, E. and Mao, C. and Brown, E. and Owens, A. and Saguner, A.M. and Meder, B. and Parikh, V. and Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14 (1): 4312. 18 July 2023

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh, Y.T. and Sona, C. and Yan, X. and Li, Y. and Pathak, A. and McDermott, M.I. and Xie, Z. and Liu, L. and Arunagiri, A. and Wang, Y. and Cazenave-Gassiot, A. and Ghosh, A. and von Meyenn, F. and Kumarasamy, S. and Najjar, S.M. and Jia, S. and Wenk, M.R. and Traynor-Kaplan, A. and Arvan, P. and Barg, S. and Bankaitis, V.A. and Poy, M.N.
Nature Communications 14 (1): 4250. 17 July 2023

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Griger, J. and Widholz, S.A. and Jesinghaus, M. and de Andrade Krätzig, N. and Lange, S. and Engleitner, T. and Montero, J.J. and Zhigalova, E. and Öllinger, R. and Suresh, V. and Winkler, W. and Lier, S. and Baranov, O. and Trozzo, R. and Ben Khaled, N. and Chakraborty, S. and Yu, J. and Konukiewitz, B. and Steiger, K. and Pfarr, N. and Rajput, A. and Sailer, D. and Keller, G. and Schirmacher, P. and Röcken, C. and Fagerstedt, K.W. and Mayerle, J. and Schmidt-Supprian, M. and Schneider, G. and Weichert, W. and Calado, D.P. and Sommermann, T. and Klöppel, G. and Rajewsky, K. and Saur, D. and Rad, R.
Cancer Cell 41 (7): 1327-1344.e10. 10 July 2023

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C. and Berger, H. and Liu, L. and Mollenkopf, H.J. and Strowig, T. and Sigal, M.
Gut Microbes 15 (1): 2233689. 10 July 2023

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Jiang, Q. and Stachelscheid, J. and Bloehdorn, J. and Pacholewska, A. and Aszyk, C.M. and Grotenhuijs, F. and Müller, T.A. and Onder, O. and Wagle, P. and Herling, C.D. and Kleppe, M. and Wang, Z. and Coombes, K.R. and Robrecht, S. and Dalvi, P.S. and Plosnita, B. and Mayer, P. and Abruzzo, L.V. and Altmüller, J. and Gathof, B.S. and Persigehl, T. and Fischer, K. and Jebaraj, B.M.C. and Rienhoff, H.Y. and Ecker, R.C. and Zhao, Y. and Bruns, C.J. and Stilgenbauer, S. and Elenitoba-Johnson, K.S.J. and Hallek, M. and Schweiger, M.R. and Odenthal, M. and Vasyutina, E. and Herling, M.
Blood 142 (1): 44-61. 6 July 2023

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J. and Costanzo, M. and Sanaki-Matsumiya, M. and Girardot, C. and Hayashi, M. and Hayashi, K. and Diecke, S. and Hildebrandt, T.B. and Lazzari, G. and Wu, J. and Petkov, S. and Behr, R. and Trivedi, V. and Matsuda, M. and Ebisuya, M.
Cell Stem Cell 30 (7): 938-949.e7. 6 July 2023

e-RNA: a collection of web-servers for the prediction and visualisation of RNA secondary structure and their functional features.
Tsybulskyi, V. and Semenchenko, E. and Meyer, I.M.
Nucleic Acids Research 51 (W1): W160-W167. 5 July 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S. and Danßmann, C. and Klironomos, F. and Winkler, A. and Fallmann, J. and Kruetzfeldt, L.M. and Szymansky, A. and Naderi, J. and Bernhart, S.H. and Grunewald, L. and Helmsauer, K. and Rodriguez-Fos, E. and Kirchner, M. and Mertins, P. and Astrahantseff, K. and Suenkel, C. and Toedling, J. and Meggetto, F. and Remke, M. and Stadler, P.F. and Hundsdoerfer, P. and Deubzer, H.E. and Künkele, A. and Lang, P. and Fuchs, J. and Henssen, A.G. and Eggert, A. and Rajewsky, N. and Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Samuelsson, A.M. and Bartolomaeus, T.U.P. and Anandakumar, H. and Thowsen, I. and Nikpey, E. and Han, J. and Marko, L. and Finne, K. and Tenstad, O. and Eckstein, J. and Berndt, N. and Kühne, T. and Kedziora, S. and Sultan, I. and Skogstrand, T. and Karlsen, T.V. and Nurmi, H. and Forslund, S.K. and Bollano, E. and Alitalo, K. and Muller, D.N. and Wiig, H.
Cardiovascular Research 119 (7): 1553-1567. 4 July 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J. and Muinjonov, B. and Rosiewicz, K.S. and Diecke, S. and Biese, C. and Schiweck, J. and Chien, C. and Zocholl, D. and Conrad, T. and Paul, F. and Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Beagrie, R.A. and Thieme, C.J. and Annunziatella, C. and Baugher, C. and Zhang, Y. and Schueler, M. and Kukalev, A. and Kempfer, R. and Chiariello, A.M. and Bianco, S. and Li, Y. and Davis, T. and Scialdone, A. and Welch, L.R. and Nicodemi, M. and Pombo, A.
Nature Methods 20 (7): 1037-1047. July 2023

Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
Bech, J.M. and Terkelsen, T. and Bartels, A.S. and Coscia, F. and Doll, S. and Zhao, S. and Zhang, Z. and Brünner, N. and Lindebjerg, J. and Madsen, G.I. and Fang, X. and Mann, M. and Moreira, J.M.A.
Gastroenterology 165 (1): 121-132.e5. July 2023

Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09-09): a randomised, open-label, multicentre, phase 3 trial.
Döhner, H. and Weber, D. and Krzykalla, J. and Fiedler, W. and Kühn, M.W.M. and Schroeder, T. and Mayer, K. and Lübbert, M. and Wattad, M. and Götze, K. and Fransecky, L. and Koller, E. and Wulf, G. and Schleicher, J. and Ringhoffer, M. and Greil, R. and Hertenstein, B. and Krauter, J. and Martens, U.M. and Nachbaur, D. and Samra, M.A. and Machherndl-Spandl, S. and Basara, N. and Leis, C. and Schrade, A. and Kapp-Schwoerer, S. and Cocciardi, S. and Bullinger, L. and Thol, F. and Heuser, M. and Paschka, P. and Gaidzik, V.I. and Saadati, M. and Benner, A. and Schlenk, R.F. and Döhner, K. and Ganser, A.
Lancet Haematology 10 (7): e495-e509. July 2023

Sex-specific microglia state in the neuroligin-4 knock-out mouse model of autism spectrum disorder.
Guneykaya, D. and Ugursu, B. and Logiacco, F. and Popp, O. and Feiks, M.A. and Meyer, N. and Wendt, S. and Semtner, M. and Cherif, F. and Gauthier, C. and Madore, C. and Yin, Z. and Çınar, Ö. and Arslan, T. and Gerevich, Z. and Mertins, P. and Butovsky, O. and Kettenmann, H. and Wolf, S.A.
Brain Behavior and Immunity 111 : 61-75. July 2023

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.
Lareau, C.A. and Dubois, S.M. and Buquicchio, F.A. and Hsieh, Y.H. and Garg, K. and Kautz, P. and Nitsch, L. and Praktiknjo, S.D. and Maschmeyer, P. and Verboon, J.M. and Gutierrez, J.C. and Yin, Y. and Fiskin, E. and Luo, W. and Mimitou, E.P. and Muus, C. and Malhotra, R. and Parikh, S. and Fleming, M.D. and Oevermann, L. and Schulte, J. and Eckert, C. and Kundaje, A. and Smibert, P. and Vardhana, S.A. and Satpathy, A.T. and Regev, A. and Sankaran, V.G. and Agarwal, S. and Ludwig, L.S.
Nature Genetics 55 (7): 1198-1209. July 2023

Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A. and Wyler, E. and Pentimalli, T.M. and Legnini, I. and Oliveras Martinez, A. and Glažar, P. and Loewa, A. and Kim, S.J. and Kaufer, B.B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
Nature Microbiology 8 (7): 1252-1266. July 2023

Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury.
Sieckmann, T. and Schley, G. and Ögel, N. and Kelterborn, S. and Boivin, F.J. and Fähling, M. and Ashraf, M.I. and Reichel, M. and Vigolo, E. and Hartner, A. and Lichtenberger, F.B. and Breiderhoff, T. and Knauf, F. and Rosenberger, C. and Aigner, F. and Schmidt-Ott, K. and Scholz, H. and Kirschner, K.M.
Kidney International 104 (1): 90-107. July 2023

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses.
Jiang, B. and Schmitt, M.J. and Rand, U. and Company, C. and Dramaretska, Y. and Grossmann, M. and Serresi, M. and Cicin-Sain, L. and Gargiulo, G.
Science Advances 9 (25): eadf4975. 23 June 2023

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
Milenkovic, I. and Santos Vieira, H.G. and Lucas, M.C. and Ruiz-Orera, J. and Patone, G. and Kesteven, S. and Wu, J. and Feneley, M. and Espadas, G. and Sabidó, E. and Hübner, N. and van Heesch, S. and Völkers, M. and Novoa, E.M.
Nucleic Acids Research 51 (11): 5301-5324. 23 June 2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M. and Schraft, L. and Chan, A. and Küchenhoff, L. and Rapti, K. and Ferreira, A.M. and Kornienko, J. and Li, S. and Radke, M.H. and Krämer, C. and Clauder-Münster, S. and Perlas, E. and Backs, J. and Gotthardt, M. and Dieterich, C. and van den Hoogenhof, M.M.G. and Grimm, D. and Steinmetz, L.M.
Nature Communications 14 (1): 3714. 22 June 2023

Transcription factor induction of vascular blood stem cell niches in vivo.
Hagedorn, E.J. and Perlin, J.R. and Freeman, R.J. and Wattrus, S.J. and Han, T. and Mao, C. and Kim, J.W. and Fernández-Maestre, I. and Daily, M.L. and D'Amato, C. and Fairchild, M.J. and Riquelme, R. and Li, B. and Ragoonanan, D.A.V.E. and Enkhbayar, K. and Henault, E.L. and Wang, H.G. and Redfield, S.E. and Collins, S.H. and Lichtig, A. and Yang, S. and Zhou, Y. and Kunar, B. and Gomez-Salinero, J.M. and Dinh, T.T. and Pan, J. and Holler, K. and Feldman, H.A. and Butcher, E.C. and van Oudenaarden, A. and Rafii, S. and Junker, J.P. and Zon, L.I.
Developmental Cell 58 (12): 1037-1051. 19 June 2023

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.
Bonifacius, A. and Lamottke, B. and Tischer-Zimmermann, S. and Schultze-Florey, R. and Goudeva, L. and Heuft, H.G. and Arseniev, L. and Beier, R. and Beutel, G. and Cario, G. and Fröhlich, B. and Greil, J. and Hansmann, L. and Hasenkamp, J. and Höfs, M. and Hundsdoerfer, P. and Jost, E. and Kafa, K. and Kriege, O. and Kröger, N. and Mathas, S. and Meisel, R. and Nathrath, M. and Putkonen, M. and Ravens, S. and Reinhardt, H.C. and Sala, E. and Sauer, M.G and Schmitt, C. and Schroers, R. and Steckel, N.K. and Trappe, R.U. and Verbeek, M. and Wolff, D. and Blasczyk, R. and Eiz-Vesper, B. and Maecker-Kolhoff, B.
Journal of Clinical Investigation 133 (12): e163548. 15 June 2023

A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P. and Orgeur, M. and Comai, G. and Poehle-Kronnawitter, S. and Fischer, C. and Gloger, M. and Dumas, C.E. and Giesecke-Thiel, C. and Sauer, S. and Tajbakhsh, S. and Höpken, U.E. and Stricker, S.
Immunity 56 (6): 1204-1219. 13 June 2023

Functional analysis of structural variants in single cells using Strand-seq.
Jeong, H. and Grimes, K. and Rauwolf, K.K. and Bruch, P.M. and Rausch, T. and Hasenfeld, P. and Benito, E. and Roider, T. and Sabarinathan, R. and Porubsky, D. and Herbst, S.A. and Erarslan-Uysal, B. and Jann, J.C. and Marschall, T. and Nowak, D. and Bourquin, J.P. and Kulozik, A.E. and Dietrich, S. and Bornhauser, B. and Sanders, A.D. and Korbel, J.O.
Nature Biotechnology 41 (6): 832-844. June 2023

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang, G. and Chiou, J. and Zeng, C. and Miller, M. and Matta, I. and Han, J.Y. and Kadakia, N. and Okino, M.L. and Beebe, E. and Mallick, M. and Camunas-Soler, J. and Dos Santos, T. and Dai, X.Q. and Ellis, C. and Hang, Y. and Kim, S.K. and MacDonald, P.E. and Kandeel, F.R. and Preissl, S. and Gaulton, K.J. and Sander, M.
Nature Genetics 55 (6): 984-994. June 2023

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy.
Erger, F. and Aryal, R.P. and Reusch, B. and Matsumoto, Y. and Meyer, R. and Zeng, J. and Knopp, C. and Noel, M. and Muerner, L. and Wenzel, A. and Kohl, S. and Tschernoster, N. and Rappl, G. and Rouvet, I. and Schröder-Braunstein, J. and Seibert, F.S. and Thiele, H. and Häusler, M.G. and Weber, L.T. and Büttner-Herold, M. and Elbracht, M. and Cummings, S.F. and Altmüller, J. and Habbig, S. and Cummings, R.D. and Beck, B.B.
Proceedings of the National Academy of Sciences of the United States of America 120 (22): e2211087120. 30 May 2023

Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez, C. and Legnini, I. and Holec, S. and Arrigoni, L. and Ozbulut, H.C. and Mateos, F. and Koppstein, D. and Rybak-Wolf, A. and Bönisch, U. and Rajewsky, N. and Hilgers, V.
Cell 186 (11): 2438-2455. 25 May 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
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Nature Communications 14 (1): 3025. 25 May 2023

Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
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Recombination between heterologous human acrocentric chromosomes.
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A draft human pangenome reference.
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Nature 617 (7960): 312-324. 11 May 2023

Increased mutation and gene conversion within human segmental duplications.
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Nature 617 (7960): 325-334. 11 May 2023

Pangenome graph construction from genome alignments with Minigraph-Cactus.
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Nature Biotechnology 10 May 2023 (In Press)

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia.
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Interferon-γ drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload.
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Cardiovascular research 119 (5): 1234-1249. May 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
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Autoantibodies targeting G protein-coupled receptors: an evolving history in autoimmunity. Report of the 4th international symposium.
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Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
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Nature Genetics 55 (5): 880-890. May 2023

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H. and Schöberl, F. and Giurgiu, M. and Leal Silva, R.M. and Scholz, V. and Scharf, F. and Wendlandt, M. and Kleinle, S. and Deschauer, M. and Nübling, G. and Heide, W. and Babacan, S.S. and Schneider, C. and Neuhann, T. and Hahn, K. and Schoser, B. and Holinski-Feder, E. and Wolf, D.A. and Abicht, A.
Brain 146 (5): 1831-1843. May 2023

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.
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Nature Protocols 18 (5): 1416-1440. May 2023

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles, G. and Adler, J.M. and Pennitz, P. and Peidli, S. and Teixeira Alves, L.G. and Baumgardt, M. and Bushe, J. and Voss, A. and Langenhagen, A. and Langner, C. and Martin Vidal, R. and Pott, F. and Kazmierski, J. and Ebenig, A. and Lange, M.V. and Mühlebach, M.D. and Goekeri, C. and Simmons, S. and Xing, N. and Abdelgawad, A. and Herwig, S. and Cichon, G. and Niemeyer, D. and Drosten, C. and Goffinet, C. and Landthaler, M. and Blüthgen, N. and Wu, H. and Witzenrath, M. and Gruber, A.D. and Praktiknjo, S.D. and Osterrieder, N. and Wyler, E. and Kunec, D. and Trimpert, J.
Nature Microbiology 8 (5): 860-874. May 2023

Gut microbiome and atrial fibrillation - results from a large population-based study.
Palmu, J. and Börschel, C.S. and Ortega-Alonso, A. and Markó, L. and Inouye, M. and Jousilahti, P. and Salido, R.A. and Sanders, K. and Brennan, C. and Humphrey, G.C. and Sanders, J.G. and Gutmann, F. and Linz, D. and Salomaa, V. and Havulinna, A.S. and Forslund, S.K. and Knight, R. and Lahti, L. and Niiranen, T. and Schnabel, R.B.
EBioMedicine 91 : 104583. May 2023

Inversion polymorphism in a complete human genome assembly.
Porubsky, D. and Harvey, W.T. and Rozanski, A.N. and Ebler, J. and Höps, W. and Ashraf, H. and Hasenfeld, P. and Paten, B. and Sanders, A.D. and Marschall, T. and Korbel, J.O. and Eichler, E.E.
Genome Biology 24 (1): 100. 30 April 2023

Clinical and prognostic relevance of cardiac wasting in patients with advanced cancer.
Lena, A. and Wilkenshoff, U. and Hadzibegovic, S. and Porthun, J. and Rösnick, L. and Fröhlich, A.K. and Zeller, T. and Karakas, M. and Keller, U. and Ahn, J. and Bullinger, L. and Riess, H. and Rosen, S.D. and Lyon, A.R. and Lüscher, T.F. and Totzeck, M. and Rassaf, T. and Burkhoff, D. and Mehra, M.R. and Bax, J.J. and Butler, J. and Edelmann, F. and Haverkamp, W. and Anker, S.D. and Packer, M. and Coats, A.J.S. and von Haehling, S. and Landmesser, U. and Anker, M.S.
Journal of the American College of Cardiology 81 (16): 1569-1586. 25 April 2023

TapA acts as specific chaperone in TasA filament formation by strand complementation.
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Proceedings of the National Academy of Sciences of the United States of America 120 (17): e2217070120. 25 April 2023

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Abbosh, C. and Frankell, A.M. and Harrison, T. and Kisistok, J. and Garnett, A. and Johnson, L. and Veeriah, S. and Moreau, M. and Chesh, A. and Chaunzwa, T.L. and Weiss, J. and Schroeder, M.R. and Ward, S. and Grigoriadis, K. and Shahpurwalla, A. and Litchfield, K. and Puttick, C. and Biswas, D. and Karasaki, T. and Black, J.R.M. and Martínez-Ruiz, C. and Bakir, M.A.l. and Pich, O. and Watkins, T.B.K. and Lim, E.L. and Huebner, A. and Moore, D.A. and Godin-Heymann, N. and L'Hernault, A. and Bye, H. and Odell, A. and Roberts, P. and Gomes, F. and Patel, A.J. and Manzano, E. and Hiley, C.T. and Carey, N. and Riley, J. and Cook, D.E. and Hodgson, D. and Stetson, D. and Barrett, J.C. and Kortlever, R.M. and Evan, G.I. and Hackshaw, A. and Daber, R.D. and Shaw, J.A. and Aerts, H.J.W.L. and Licon, A. and Stahl, J. and Jamal-Hanjani, M. and Birkbak, N.J. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 553-562. 20 April 2023

The evolution of lung cancer and impact of subclonal selection in TRACERx.
Frankell, A.M. and Dietzen, M. and Al Bakir, M. and Lim, E.L. and Karasaki, T. and Ward, S. and Veeriah, S. and Colliver, E. and Huebner, A. and Bunkum, A. and Hill, M.S. and Grigoriadis, K. and Moore, D.A. and Black, J.R.M. and Liu, W.K. and Thol, K. and Pich, O. and Watkins, T.B.K. and Naceur-Lombardelli, C. and Cook, D.E. and Salgado, R. and Wilson, G.A. and Bailey, C. and Angelova, M. and Bentham, R. and Martínez-Ruiz, C. and Abbosh, C. and Nicholson, A.G. and Le Quesne, J. and Biswas, D. and Rosenthal, R. and Puttick, C. and Hessey, S. and Lee, C. and Prymas, P. and Toncheva, A. and Smith, J. and Xing, W. and Nicod, J. and Price, G. and Kerr, K.M. and Naidu, B. and Middleton, G. and Blyth, K.G. and Fennell, D.A. and Forster, M.D. and Lee, S.M. and Falzon, M. and Hewish, M. and Shackcloth, M.J. and Lim, E. and Benafif, S. and Russell, P. and Boleti, E. and Krebs, M.G. and Lester, J.F. and Papadatos-Pastos, D. and Ahmad, T. and Thakrar, R.M. and Lawrence, D. and Navani, N. and Janes, S.M. and Dive, C. and Blackhall, F.H and Summers, Y. and Cave, J. and Marafioti, T. and Herrero, J. and Quezada, S.A. and Peggs, K.S. and Schwarz, R.F. and Van Loo, P. and Miedema, D.M. and Birkbak, N.J. and Hiley, C.T. and Hackshaw, A. and Zaccaria, S. and Jamal-Hanjani, M. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 525-533. 20 April 2023

The little skate genome and the evolutionary emergence of wing-like fins.
Marlétaz, F. and de la Calle-Mustienes, E. and Acemel, R.D. and Paliou, C. and Naranjo, S. and Martínez-García, P.M. and Cases, I. and Sleight, V.A. and Hirschberger, C. and Marcet-Houben, M. and Navon, D. and Andrescavage, A. and Skvortsova, K. and Duckett, P.Ed. and González-Rajal, Á. and Bogdanovic, O. and Gibcus, J.H. and Yang, L. and Gallardo-Fuentes, L. and Sospedra, I. and Lopez-Rios, J. and Darbellay, F. and Visel, A. and Dekker, J. and Shubin, N. and Gabaldón, T. and Nakamura, T. and Tena, J.J. and Lupianez, D.G. and Rokhsar, D.S. and Gómez-Skarmeta, J.L.
Nature 616 (7957): 495-503. 20 April 2023

Genomic–transcriptomic evolution in lung cancer and metastasis.
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Nature 616 (7957): 543-552. 20 April 2023

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng, K.W. and Boumelha, J. and Enfield, K.S.S. and Almagro, J. and Cha, H. and Pich, O. and Karasaki, T. and Moore, D.A. and Salgado, R. and Sivakumar, M. and Young, G. and Molina-Arcas, M. and de Carné Trécesson, S. and Anastasiou, P. and Fendler, A. and Au, L. and Shepherd, S.T.C. and Martínez-Ruiz, C. and Puttick, C. and Black, J.R.M. and Watkins, T.B.K. and Kim, H. and Shim, S. and Faulkner, N. and Attig, J. and Veeriah, S. and Magno, N. and Ward, S. and Frankell, A.M. and Al Bakir, M. and Lim, E.L. and Hill, M.S. and Wilson, G.A. and Cook, D.E. and Birkbak, N.J. and Behrens, A. and Yousaf, N. and Popat, S. and Hackshaw, A. and Hiley, C.T. and Litchfield, K. and McGranahan, N. and Jamal-Hanjani, M. and Larkin, J. and Lee, S.H. and Turajlic, S. and Swanton, C. and Downward, J. and Kassiotis, G.
Nature 616 (7957): 563-573. 20 April 2023

A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
Huljev, K. and Shamipour, S. and Pinheiro, D. and Preusser, F. and Steccari, I. and Sommer, C.M. and Naik, S. and Heisenberg, C.P.
Developmental Cell 58 (7): 582-596.e7. 10 April 2023

Lung adenocarcinoma promotion by air pollutants.
Hill, W. and Lim, E.L. and Weeden, C.E. and Lee, C. and Augustine, M. and Chen, K. and Kuan, F.C. and Marongiu, F. and Evans, E.J. and Moore, D.A. and Rodrigues, F.S. and Pich, O. and Bakker, B. and Cha, H. and Myers, R. and van Maldegem, F. and Boumelha, J. and Veeriah, S. and Rowan, A. and Naceur-Lombardelli, C. and Karasaki, T. and Sivakumar, M. and De, S. and Caswell, D.R. and Nagano, A. and Black, J.R.M. and Martínez-Ruiz, C. and Ryu, M.H. and Huff, R.D. and Li, S. and Favé, M.J. and Magness, A. and Suárez-Bonnet, A. and Priestnall, S.L. and Lüchtenborg, M. and Lavelle, K. and Pethick, J. and Hardy, S. and McRonald, F.E. and Lin, M.H. and Troccoli, C.I. and Ghosh, M. and Miller, Y.E. and Merrick, D.T. and Keith, R.L. and Al Bakir, M. and Bailey, C. and Hill, M.S. and Saal, L.H. and Chen, Y. and George, A.M. and Abbosh, C. and Kanu, N. and Lee, S.H. and McGranahan, N. and Berg, C.D. and Sasieni, P. and Houlston, R. and Turnbull, C. and Lam, S. and Awadalla, P. and Grönroos, E. and Downward, J. and Jacks, T. and Carlsten, C. and Malanchi, I. and Hackshaw, A. and Litchfield, K. and DeGregori, J. and Jamal-Hanjani, M. and Swanton, C.
Nature 616 (7955): 159-167. 6 April 2023

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees, T.A. and Wang, N. and Adamek, P. and Zeitzschel, N. and Verkest, C. and La Porta, C. and Schaefer, I. and Virnich, J. and Balkaya, S. and Prato, V. and Morelli, C. and Begay, V. and Lee, Y.J. and Tappe-Theodor, A. and Lewin, G.R. and Heppenstall, P.A. and Taberner, F.J. and Lechner, S.G.
Nature Communications 14 (1): 1899. 5 April 2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell, H. and Fazio, L. and Dyckow, J. and Schwarz, S. and Cruz-Herranz, A. and Campos, J. and Mayer, C. and D Este, E. and Möbius, W. and Cordano, C. and Pröbstel, A.K. and Gharagozloo, M. and Zulji, A. and Narayanan Naik, V. and Delank, A.K. and Cerina, M. and Müntefering, T. and Lerma-Martin, C. and Sonner, J.K. and Sin, J.H. and Disse, P. and Rychlik, N. and Sabeur, K. and Chavali, M. and Srivastava, R. and Heidenreich, M. and Fitzgerald, K.C. and Seebohm, G. and Stadelmann, C. and Hemmer, B. and Platten, M. and Jentsch, T.J. and Engelhardt, M. and Budde, T. and Nave, K.A. and Calabresi, P.A. and Friese, M.A. and Green, A.J. and Acuna, C. and Rowitch, D.H. and Meuth, S.G. and Schirmer, L.
Journal of Clinical Investigation 133 (7): e164223. 3 April 2023

The evolution of non-small cell lung cancer metastases in TRACERx.
Al Bakir, M. and Huebner, A. and Martínez-Ruiz, C. and Grigoriadis, K. and Watkins, T.B.K. and Pich, O. and Moore, D.A. and Veeriah, S. and Ward, S. and Laycock, J. and Johnson, D. and Rowan, A. and Razaq, M. and Akther, M. and Naceur-Lombardelli, C. and Prymas, P. and Toncheva, A. and Hessey, S. and Dietzen, M. and Colliver, E. and Frankell, A.M. and Bunkum, A. and Lim, E.L. and Karasaki, T. and Abbosh, C. and Hiley, C.T. and Hill, M.S. and Cook, D.E. and Wilson, G.A. and Salgado, R. and Nye, E. and Stone, R.K. and Fennell, D.A. and Price, G. and Kerr, K.M. and Naidu, B. and Middleton, G. and Summers, Y. and Lindsay, C.R. and Blackhall, F.H. and Cave, J. and Blyth, K.G. and Nair, A. and Ahmed, A. and Taylor, M.N. and Procter, A.J. and Falzon, M. and Lawrence, D. and Navani, N. and Thakrar, R.M. and Janes, S.M. and Papadatos-Pastos, D. and Forster, M.D. and Lee, S.M. and Ahmad, T. and Quezada, S.A. and Peggs, K.S. and Van Loo, P. and Dive, C. and Hackshaw, A. and Birkbak, N.J. and Zaccaria, S. and Jamal-Hanjani, M. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 534-542. April 2023

Body composition and lung cancer-associated cachexia in TRACERx.
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Nature Medicine 29 (4): 846-858. April 2023

A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean, J. and Desrosiers-Gregoire, G. and Anckaerts, C. and Angeles-Valdez, D. and Ayad, F. and Barrière, D.A. and Blockx, I. and Bortel, A. and Broadwater, M. and Cardoso, B.M. and Célestine, M. and Chavez-Negrete, J.E. and Choi, S. and Christiaen, E. and Clavijo, P. and Colon-Perez, L. and Cramer, S. and Daniele, T. and Dempsey, E. and Diao, Y. and Doelemeyer, A. and Dopfel, D. and Dvořáková, L. and Falfán-Melgoza, C. and Fernandes, F.F. and Fowler, C.F. and Fuentes-Ibañez, A. and Garin, C.M. and Gelderman, E. and Golden, C.E.M. and Guo, C.C G. and Henckens, M.J.A.G. and Hennessy, L.A. and Herman, P. and Hofwijks, N. and Horien, C. and Ionescu, T.M. and Jones, J. and Kaesser, J. and Kim, E. and Lambers, H. and Lazari, A. and Lee, S.H. and Lillywhite, A. and Liu, Y. and Liu, Y.Y. and López-Castro, A. and López-Gil, X. and Ma, Z. and MacNicol, E. and Madularu, D. and Mandino, F. and Marciano, S. and McAuslan, M.J. and McCunn, P. and McIntosh, A. and Meng, X. and Meyer-Baese, L. and Missault, S. and Moro, F. and Naessens, D.M.P. and Nava-Gomez, L.J. and Nonaka, H. and Ortiz, J.J. and Paasonen, J. and Peeters, L.M. and Pereira, M. and Perez, P.D. and Pompilus, M. and Prior, M. and Rakhmatullin, R. and Reimann, H.M. and Reinwald, J. and Del Rio, R.T. and Rivera-Olvera, A. and Ruiz-Pérez, D. and Russo, G. and Rutten, T.J. and Ryoke, R. and Sack, M. and Salvan, P. and Sanganahalli, B.G. and Schroeter, A. and Seewoo, B.J. and Selingue, E. and Seuwen, A. and Shi, B. and Sirmpilatze, N. and Smith, J.A.B. and Smith, C. and Sobczak, F. and Stenroos, P.J. and Straathof, M. and Strobelt, S. and Sumiyoshi, A. and Takahashi, K. and Torres-García, M.E and Tudela, R. and van den Berg, M. and van der Marel, K. and van Hout, A.T.B. and Vertullo, R. and Vidal, B. and Vrooman, R.M. and Wang, V.X. and Wank, I. and Watson, D.J.G. and Yin, T. and Zhang, Y. and Zurbruegg, S. and Achard, S. and Alcauter, S. and Auer, D.P. and Barbier, E.L. and Baudewig, J. and Beckmann, C.F. and Beckmann, N. and Becq, G.J.P.C. and Blezer, E.L.A. and Bolbos, R. and Boretius, S. and Bouvard, S. and Budinger, E. and Buxbaum, J.D. and Cash, D. and Chapman, V. and Chuang, K.H. and Ciobanu, L. and Coolen, B.F. and Dalley, J.W. and Dhenain, M. and Dijkhuizen, R.M. and Esteban, O. and Faber, C. and Febo, M. and Feindel, K.W. and Forloni, G. and Fouquet, J. and Garza-Villarreal, E.A. and Gass, N. and Glennon, J.C. and Gozzi, A. and Gröhn, O. and Harkin, A. and Heerschap, A. and Helluy, X. and Herfert, K. and Heuser, A. and Homberg, J.R. and Houwing, D.J. and Hyder, F. and Ielacqua, G.D. and Jelescu, I.O. and Johansen-Berg, H. and Kaneko, G. and Kawashima, R. and Keilholz, S.D. and Keliris, G.A. and Kelly, C. and Kerskens, C. and Khokhar, J.Y. and Kind, P.C. and Langlois, J.B. and Lerch, J.P. and López-Hidalgo, M.A and Manahan-Vaughan, D. and Marchand, F. and Mars, R.B. and Marsella, G. and Micotti, E. and Muñoz-Moreno, E. and Near, J. and Niendorf, T. and Otte, W.M. and Pais-Roldán, P. and Pan, W.J. and Prado-Alcalá, R.A. and Quirarte, G.L. and Rodger, J. and Rosenow, T. and Sampaio-Baptista, C. and Sartorius, A. and Sawiak, S.J. and Scheenen, T.W.J. and Shemesh, N. and Shih, Y.Y.I. and Shmuel, A. and Soria, G. and Stoop, R. and Thompson, G.J. and Till, S.M. and Todd, N. and Van Der Linden, A. and van der Toorn, A. and van Tilborg, G.A.F and Vanhove, C. and Veltien, A. and Verhoye, M. and Wachsmuth, L. and Weber-Fahr, W. and Wenk, P. and Yu, X. and Zerbi, V. and Zhang, N. and Zhang, B.B. and Zimmer, L. and Devenyi, G.A. and Chakravarty, M.M. and Hess, A.
Nature Neuroscience 26 (4): 673-681. April 2023

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
Karasaki, T. and Moore, D.A. and Veeriah, S. and Naceur-Lombardelli, C. and Toncheva, A. and Magno, N. and Ward, S. and Bakir, M.A. and Watkins, T.B.K. and Grigoriadis, K. and Huebner, A. and Hill, M.S. and Frankell, A.M. and Abbosh, C. and Puttick, C. and Zhai, H. and Gimeno-Valiente, F. and Saghafinia, S. and Kanu, N. and Dietzen, M. and Pich, O. and Lim, E.. and Martínez-Ruiz, C. and Black, J.R.M. and Biswas, D. and Campbell, B.B. and Lee, C. and Colliver, E. and Enfield, K.S.S. and Hessey, S. and Hiley, C.T. and Zaccaria, S. and Litchfield, K. and Birkbak, N.J. and Cadieux, E.L. and Demeulemeester, J. and Van Loo, P. and Adusumilli, P.S. and Tan, K.S. and Cheema, W. and Sanchez-Vega, F. and Jones, D.R. and Rekhtman, N. and Travis, W.D. and Hackshaw, A. and Marafioti, T. and Salgado, R. and Le Quesne, J. and Nicholson, A.G. and McGranahan, N. and Swanton, C. and Jamal-Hanjani, M.
Nature Medicine 29 (4): 833-845. April 2023

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera, J.A. and Leu, C. and Macnee, M. and Khoury, J. and Hoffmann, L. and Coras, R. and Kobow, K. and Bhattarai, N. and Pérez-Palma, E. and Hamer, H. and Brandner, S. and Rössler, K. and Bien, C.G. and Kalbhenn, T. and Pieper, T. and Hartlieb, T. and Butler, E. and Genovese, G. and Becker, K. and Altmüller, J. and Niestroj, L.M. and Ferguson, L. and Busch, R.M. and Nürnberg, P. and Najm, I. and Blümcke, I. and Lal, D.
Brain 146 (4): 1342-1356. April 2023

COVID-19 and cellular senescence.
Schmitt, C.A. and Tchkonia, T. and Niedernhofer, L.J. and Robbins, P.D. and Kirkland, J.L. and Lee, S.
Nature Reviews Immunology 23 (4): 251-263. April 2023

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
Straube, J. and Eifert, T. and Vu, T. and Janardhanan, Y. and Haldar, R. and von Eyss, B. and Cooper, L. and Bruedigam, C. and Ling, V.Y. and Cooper, E. and Patch, A.M. and Bullinger, L. and Schnoeder, T.M. and Bywater, M. and Heidel, F.H. and Lane, S.W.
Leukemia 37 (4): 741-750. April 2023

Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert, R. and Hetzel, S. and Bailly, N. and Haggerty, C. and Ilik, I.A. and Yung, P.Y.K. and Navarro, C. and Bolondi, A. and Kumar, A.S. and Anania, C. and Brändl, B. and Meierhofer, D. and Lupianez, D.G. and Müller, F.J. and Aktas, T. and Elsässer, S.J. and Kretzmer, H. and Smith, Z.D. and Meissner, A.
Nature Cell Biology 25 : 579–591. April 2023

Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root.
Nolan, T.M. and Vukašinović, N. and Hsu, C.W. and Zhang, J. and Vanhoutte, I. and Shahan, R. and Taylor, I.W. and Greenstreet, L. and Heitz, M. and Afanassiev, A. and Wang, P. and Szekely, P. and Brosnan, A. and Yin, Y. and Schiebinger, G. and Ohler, U. and Russinova, E. and Benfey, P.N.
Science 379 (6639): eadf4721. 31 March 2023

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
Subramaniam, G. and Schleicher, K. and Kovanich, D. and Zerio, A. and Folkmanaite, M. and Chao, Y.C. and Surdo, N.C. and Koschinski, A. and Hu, J. and Scholten, A. and Heck, A.J.R and Ercu, M. and Sholokh, A. and Chan Park, K. and Klussmann, E. and Meraviglia, V. and Bellin, M. and Zanivan, S. and Hester, S. and Mohammed, S. and Zaccolo, M.
Circulation Research 132 (7): 828-848. 31 March 2023

Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Malinovska, L. and Cappelletti, V. and Kohler, D. and Piazza, I. and Tsai, T.H. and Pepelnjak, M. and Stalder, P. and Dörig, C. and Sesterhenn, F. and Elsässer, F. and Kralickova, L. and Beaton, N. and Reiter, L. and de Souza, N. and Vitek, O. and Picotti, P.
Nature Protocols 18 : 659-682. 16 March 2023

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L. and Schulz, J.F. and Ruiz-Orera, J. and Kirchner, M. and Ziehm, M. and Adami, E. and Marczenke, M. and Christ, A. and Liebe, N. and Greiner, J. and Schoenenberger, A. and Mücke, M.B. and Liang, N. and Moritz, R.L. and Sun, Z. and Deutsch, E.W. and Gotthardt, M. and Mudge, J.M. and Prensner, J.R. and Willnow, T.E. and Mertins, P. and van Heesch, S. and Hubner, N.
Molecular Cell 83 (6): 994-1011.e18. 16 March 2023

Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Richter, F.C. and Friedrich, M. and Kampschulte, N. and Piletic, K. and Alsaleh, G. and Zummach, R. and Hecker, J. and Pohin, M. and Ilott, N. and Guschina, I. and Wideman, S.K. and Johnson, E. and Borsa, M. and Hahn, P. and Morriseau, C. and Hammock, B.D. and Schipper, H.S. and Edwards, C.M and Zechner, R. and Siegmund, B. and Weidinger, C. and Schebb, N.H. and Powrie, F. and Simon, A.K.
EMBO Journal 42 (6): e112202. 15 March 2023

Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
Kalkan, H. and Pagano, E. and Paris, D. and Panza, E. and Cuozzo, M. and Moriello, C. and Piscitelli, F. and Abolghasemi, A. and Gazzerro, E. and Silvestri, C. and Capasso, R. and Motta, A. and Russo, R. and Di Marzo, V. and Iannotti, F.A.
EMBO Molecular Medicine 15 (3): e16225. 8 March 2023

Mouse models of human multiple myeloma subgroups.
Winkler, W. and Farré Díaz, C. and Blanc, E. and Napieczynska, H. and Langner, P. and Werner, M. and Walter, B. and Wollert-Wulf, B. and Yasuda, T. and Heuser, A. and Beule, D. and Mathas, S. and Anagnostopoulos, I. and Rosenwald, A. and Rajewsky, K. and Janz, M.
Proceedings of the National Academy of Sciences of the United States of America 120 (10): e2219439120. 7 March 2023

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier, M. and Gupta, M. and Akgül, S. and McDougall, M. and Imhof, T. and Nikodemus, D. and Reuten, R. and Moya-Torres, A. and To, V. and Ferens, F. and Heide, F. and Padilla-Meier, G.P. and Kukura, P. and Huang, W. and Gerisch, B. and Mörgelin, M. and Poole, K. and Antebi, A. and Koch, M. and Stetefeld, J.
Nature Communications 14 (1): 1226. 3 March 2023

Mitochondrial DNA mutations as natural barcodes for lineage tracing of murine tumor models.
Penter, L. and Ten Hacken, E. and Southard, J. and Lareau, C. and Ludwig, L.S. and Li, S. and Neuberg, D.S. and Livak, K.J. and Wu, C.J.
Cancer Research 83 (5): 667-672. 1 March 2023

Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced stage Hodgkin Lymphoma: results from the randomized international GHSG HD18 trial.
Ferdinandus, J. and Müller, H. and Damaschin, C. and Jacob, A.S. and Meissner, J. and Krasniqi, F. and Mey, U. and Schöndube, D. and Thiemer, J. and Mathas, S. and Zijlstra, J. and Greil, R. and Feuring-Buske, M. and Markova, J. and Rüffer, J.U. and Kobe, C. and Eich, H.T. and Baues, C. and Fuchs, M. and Borchmann, P. and Behringer, K.
Annals of Oncology 35 (3): 276-284. March 2023

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F. and Thakkar, M. and Hamann, W. and Lopez Carballo, J. and Jüttner, R. and Voss, F.K. and Becher, P.M. and Westermann, D. and Tschöpe, C. and Heuser, A. and Rocks, O. and Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

HNF1B alters an evolutionarily conserved nephrogenic program of target genes.
Grand, K. and Stoltz, M. and Rizzo, L. and Röck, R. and Kaminski, M.M. and Salinas, G. and Getwan, M. and Naert, T. and Pichler, R. and Lienkamp, S.S.
Journal of the American Society of Nephrology 34 (3): 412-432. March 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J. and Gout, E. and Daniau, L. and Lao, J. and Weißert, K. and Ammann, S. and Kühn, R. and Richter, M. and Molenda, C. and Sporbert, A. and Zocholl, D. and Klopfleisch, R. and Lortat-Jacob, H. and Aichele, P. and Kammertoens, T. and Blankenstein, T.
Nature Immunology 24 (3): 414-422. March 2023

Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S. and von Kügelgen, N. and Dantsuji, S. and Ron, M. and Breimann, L. and Baranovskii, A. and Lödige, I. and Kirchner, M. and Fischer, M. and Zerna, N. and Bujanic, L. and Mertins, P. and Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26 (3): 394-405. March 2023

The cellular coding of temperature in the mammalian cortex.
Vestergaard, M. and Carta, M. and Güney, G. and Poulet, J.F.A.
Nature 614 (7949): 725-731. 23 February 2023

Nivolumab and doxorubicin, vinblastine, and dacarbazine in early-stage unfavorable Hodgkin Lymphoma: final analysis of the randomized german Hodgkin study group phase II NIVAHL trial.
Bröckelmann, P.J. and Bühnen, I. and Meissner, J. and Trautmann-Grill, K. and Herhaus, P. and Halbsguth, T.V. and Schaub, V. and Kerkhoff, A. and Mathas, S. and Bormann, M. and Dickhut, A. and Kaul, H. and Fuchs, M. and Kobe, C. and Baues, C. and Borchmann, P. and Engert, A. and von Tresckow, B.
Journal of Clinical Oncology 41 (6): 1193-1199. 20 February 2023

Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li, B. and Zeis, P. and Zhang, Y. and Alekseenko, A. and Fürst, E. and Sanchez, Y.P. and Lin, G. and Tekkedil, M.M. and Piazza, I. and Steinmetz, L.M. and Pelechano, V.
Nature Communications 14 (1): 910. 17 February 2023

Cryo-EM captures early ribosome assembly in action.
Qin, B. and Lauer, S.M. and Balke, A. and Vieira-Vieira, C.H. and Bürger, J. and Mielke, T. and Selbach, M. and Scheerer, P. and Spahn, C.M.T. and Nikolay, R.
Nature Communications 14 (1): 898. 17 February 2023

Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.
Arends, C.M. and Liman, T.G. and Strzelecka, P.M. and Kufner, A. and Löwe, P. and Huo, S. and Stein, C.M. and Piper, S.K. and Tilgner, M. and Sperber, P.S. and Dimitriou, S. and Heuschmann, P. and Hablesreiter, R. and Harms, C. and Bullinger, L. and Weber, J.E. and Endres, M. and Damm, F.
Blood 141 (7): 787-799. 16 February 2023

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes, R. and Pascual-Reguant, A. and Koehler, R. and Liebeskind, J. and Liebheit, A. and Bauherr, S. and Philipsen, L. and Dittmayer, C. and Laue, M. and von Manitius, R. and Elezkurtaj, S. and Durek, P. and Heinrich, F. and Heinz, G.A. and Guerra, G.M. and Obermayer, B. and Meinhardt, J. and Ihlow, J. and Radke, J. and Heppner, F.L. and Enghard, P. and Stockmann, H. and Aschman, T. and Schneider, J. and Corman, V.M. and Sander, L.E. and Mashreghi, M.F. and Conrad, T. and Hocke, A.C. and Niesner, R.A. and Radbruch, H. and Hauser, A.E.
Nature Communications 14 (1): 791. 11 February 2023

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
Danielli, S.G. and Porpiglia, E. and De Micheli, A.J. and Navarro, N. and Zellinger, M.J. and Bechtold, I. and Kisele, S. and Volken, L. and Marques, J.G. and Kasper, S. and Bode, P.K. and Henssen, A.G. and Gürgen, D. and Delattre, O. and Surdez, D. and Roma, J. and Bühlmann, P. and Blau, H.M. and Wachtel, M. and Schäfer, B.W.
Science Advances 9 (6): eade9238. 10 February 2023

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F. and Hamad, I. and Arroyo Hornero, R. and Geisberger, S. and Roels, J. and Van Zeebroeck, L. and Dyczko, A. and van Gisbergen, M.W. and Kurniawan, H. and Wagner, A. and Yosef, N. and Weiss, S.N.Y. and Schmetterer, K.G. and Schröder, A. and Krampert, L. and Haase, S. and Bartolomaeus, H. and Hellings, N. and Saeys, Y. and Dubois, L.J. and Brenner, D. and Kempa, S. and Hafler, D.A. and Stegbauer, J. and Linker, R.A. and Jantsch, J. and Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35 (2): 299-315. 7 February 2023

First in vivo fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod.
Starke, L. and Millward, J.M. and Prinz, C. and Sherazi, F. and Waiczies, H. and Lippert, C. and Nazaré, M. and Paul, F. and Niendorf, T. and Waiczies, S.
Theranostics 13 (4): 1217-1234. 5 February 2023

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
Lopez, C. and Schleussner, N. and Bernhart, S.H. and Kleinheinz, K. and Sungalee, S. and Sczakiel, H.L. and Kretzmer, H. and Toprak, U.H. and Glaser, S. and Wagener, R. and Ammerpohl, O. and Bens, S. and Giefing, M. and Sanchez, J.C.G. and Apic, G. and Hubschmann, D. and Janz, M. and Kreuz, M. and Mottok, A. and Müller, J.M. and Seufert, J. and Hoffmann, S. and Korbel, J.O. and Russell, R.B. and Schule, R. and Trumper, L. and Klapper, W. and Radlwimmer, B. and Lichter, P. and Kuppers, R. and Schlesner, M. and Mathas, S. and Siebert, R.
Haematologica 108 (2): 543-554. 1 February 2023

SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A. and López-Cayuqueo, K.I. and Scherer, N. and Wuttke, M. and Wernstedt, A. and González Fassrainer, D. and Smith, D.E. and van de Kamp, J.M. and Ziegeler, K. and Eckardt, K.U. and Luft, F.C. and Aronson, P.S. and Köttgen, A. and Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133 (3): e161849. 1 February 2023

Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
Boogerd, C.J. and Lacraz, G.P.A. and Vértesy, Á. and van Kampen, S.J. and Perini, I. and de Ruiter, H. and Versteeg, D. and Brodehl, A. and van der Kraak, P. and Giacca, M. and de Jonge, N. and Junker, J.P. and van Oudenaarden, A. and Vink, A. and van Rooij, E.
Cardiovascular Research 119 (2): 477-491. February 2023

Small molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Demel, U.M. and Wirth, M. and Yousefian, S. and Zhang, L. and Isaakidis, K. and Dönig, J. and Böger, M. and Singh, N. and Köse, H. and Haas, S. and Müller, S. and Schick, M. and Keller, U.
Haematologica 108 (2): 555-567. February 2023

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
Mansouri, L. and Thorvaldsdottir, B. and Sutton, L.A. and Karakatsoulis, G. and Meggendorfer, M. and Parker, H. and Nadeu, F. and Brieghel, C. and Laidou, S. and Moia, R. and Rossi, D. and Catherwood, M. and Kotaskova, J. and Delgado, J. and Rodríguez-Vicente, A.E. and Benito, R. and Rigolin, G.M. and Bonfiglio, S. and Scarfo, L. and Mattsson, M. and Davis, Z. and Gogia, A. and Rani, L. and Baliakas, P. and Foroughi-Asl, H. and Jylhä, C. and Skaftason, A. and Rapado, I. and Miras, F. and Martinez-Lopez, J. and de la Serna, J. and Rivas, J.M.H. and Thornton, P. and Larráyoz, M.J. and Calasanz, M.J. and Fésüs, V. and Mátrai, Z. and Bödör, C. and Smedby, K.E. and Espinet, B. and Puiggros, A. and Gupta, R. and Bullinger, L. and Bosch, F. and Tazón-Vega, B. and Baran-Marszak, F. and Oscier, D. and Nguyen-Khac, F. and Zenz, T. and Terol, M.J. and Cuneo, A. and Hernández-Sánchez, M. and Pospisilova, S. and Mills, K. and Gaidano, G. and Niemann, C.U. and Campo, E. and Strefford, J.C. and Ghia, P. and Stamatopoulos, K. and Rosenquist, R.
Leukemia 37 (2): 339-347. February 2023

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy.
Plewa, N. and Poncette, L. and Blankenstein, T.
Journal for ImmunoTherapy of Cancer 11 (2): e006001. February 2023

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
Kennedy, K.M. and de Goffau, M.C. and Perez-Muñoz, M.E. and Arrieta, M.C. and Bäckhed, F. and Bork, P. and Braun, T. and Bushman, F.D. and Dore, J. and de Vos, W.M. and Earl, A.M. and Eisen, J.A. and Elovitz, M.A. and Ganal-Vonarburg, S.C. and Gänzle, M.G. and Garrett, W.S. and Hall, L.J. and Hornef, M.W. and Huttenhower, C. and Konnikova, L. and Lebeer, S. and Macpherson, A.J. and Massey, R.C. and McHardy, A.C. and Koren, O. and Lawley, T.D. and Ley, R.E. and O'Mahony, L. and O'Toole, P.W. and Pamer, E.G. and Parkhill, J. and Raes, J. and Rattei, T. and Salonen, A. and Segal, E. and Segata, N. and Shanahan, F. and Sloboda, D.M. and Smith, G.C.S. and Sokol, H. and Spector, T.D. and Surette, M.G. and Tannock, G.W. and Walker, A.W. and Yassour, M. and Walter, J.
Nature 613 (7945): 639-649. 26 January 2023

CYCLeR - a novel tool for the full isoform assembly and quantification of circRNAs.
Stefanov, S.R. and Meyer, I.M.
Nucleic Acids Research 51 (2): e10. 25 January 2023

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S. and Roske, Y. and Rami, B. and Phan, M.H.Q. and Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120 (4): e2208941120. 24 January 2023

Radiofrequency induced heating of biodegradable orthopaedic screw implants during magnetic resonance imaging.
Espiritu, J. and Berangi, M. and Cwieka, H. and Iskhakova, K. and Kuehne, A. and Florian Wieland, D.C. and Zeller-Plumhoff, B. and Niendorf, T. and Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 25 : 86-94. 23 January 2023

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel, L.M. and Franke, V. and Benedum, J. and Grishkovskaya, I. and Strobl, X. and Polyansky, A. and Ammann, G. and Platzer, S. and Neudolt, A. and Wunder, A. and Walch, L. and Kaiser, S. and Zagrovic, B. and Djinovic-Carugo, K. and Akalin, A. and Slade, D.
Nature Communications 14 (1): 166. 11 January 2023

proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes.
Fullam, A. and Letunic, I. and Schmidt, T.S.B. and Ducarmon, Q.R. and Karcher, N. and Khedkar, S. and Kuhn, M. and Larralde, M. and Maistrenko, O.M. and Malfertheiner, L. and Milanese, A. and Rodrigues, J.F.M. and Sanchis-López, C. and Schudoma, C. and Szklarczyk, D. and Sunagawa, S. and Zeller, G. and Huerta-Cepas, J. and von Mering, C. and Bork, P. and Mende, D.R.
Nucleic Acids Research 51 (D1): D760-D766. 6 January 2023

The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.
Szklarczyk, D. and Kirsch, R. and Koutrouli, M. and Nastou, K. and Mehryary, F. and Hachilif, R. and Gable, A.L. and Fang, T. and Doncheva, N.T. and Pyysalo, S. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 51 (D1): D638-D646. 6 January 2023

The gut microbiota in multiple sclerosis varies with disease activity.
Thirion, F. and Sellebjerg, F. and Fan, Y. and Lyu, L. and Hansen, T.H. and Pons, N. and Levenez, F. and Quinquis, B. and Stankevic, E. and Søndergaard, H.B. and Dantoft, T.M. and Poulsen, C.S. and Forslund, S.K. and Vestergaard, H. and Hansen, T. and Brix, S. and Oturai, A. and Sørensen, P.S. and Ehrlich, S.D. and Pedersen, O.
Genome Medicine 15 (1): 1. 5 January 2023

Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.
Denkinger, C.M. and Janssen, M. and Schäkel, U. and Gall, J. and Leo, A. and Stelmach, P. and Weber, S.F. and Krisam, J. and Baumann, L. and Stermann, J. and Merle, U. and Weigand, M.A. and Nusshag, C. and Bullinger, L. and Schrezenmeier, J.F. and Bornhäuser, M. and Alakel, N. and Witzke, O. and Wolf, T. and Vehreschild, M.J.G.T. and Schmiedel, S. and Addo, M.M. and Herth, F. and Kreuter, M. and Tepasse, P.R. and Hertenstein, B. and Hänel, M. and Morgner, A. and Kiehl, M. and Hopfer, O. and Wattad, M.A. and Schimanski, C.C. and Celik, C. and Pohle, T. and Ruhe, M. and Kern, W.V. and Schmitt, A. and Lorenz, H.M. and Souto-Carneiro, M. and Gaeddert, M. and Halama, N. and Meuer, S. and Kräusslich, H.G. and Müller, B. and Schnitzler, P. and Parthé, S. and Bartenschlager, R. and Gronkowski, M. and Klemmer, J. and Schmitt, M. and Dreger, P. and Kriegsmann, K. and Schlenk, Ri.F. and Müller-Tidow, C.
Nature Cancer 4 (1): 96-107. January 2023

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
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Science Immunology 8 (79): eade7953. January 2023

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia.
Ling, V.Y. and Straube, J. and Godfrey, W. and Haldar, R. and Janardhanan, Y. and Cooper, L. and Bruedigam, C. and Cooper, E. and Tavakoli Shirazi, P. and Jacquelin, S. and Tey, S.K. and Baell, J. and Huang, F. and Jin, J. and Zhao, Y. and Bullinger, L. and Bywater, M.J. and Lane, S.W.
Leukemia 37 (1): 143-153. January 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations.
Malin-Mayor, C. and Hirsch, P. and Guignard, L. and McDole, K. and Wan, Y. and Lemon, W.C. and Kainmueller, D. and Keller, P.J. and Preibisch, S. and Funke, J.
Nature Biotechnology 44 (1): 44-49. January 2023

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
Keil, P. and Wulf, A. and Kachariya, N. and Reuscher, S. and Hühn, K. and Silbern, I. and Altmüller, J. and Keller, M. and Stehle, R. and Zarnack, K. and Sattler, M. and Urlaub, H. and Sträßer, K.
Nucleic Acids Research : gkac1206. 30 December 2022

Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by integrated multi-omic analyses.
Kunath, B.J. and Hickl, O. and Queirós, P. and Martin-Gallausiaux, C. and Lebrun, L.A. and Halder, R. and Laczny, C.C. and Schmidt, T.S.B. and Hayward, M.R. and Becher, D. and Heintz-Buschart, A. and de Beaufort, C. and Bork, P. and May, P. and Wilmes, P.
Microbiome 10 (1): 243. 28 December 2022

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
Brauneck, F. and Fischer, B. and Witt, M. and Muschhammer, J. and Oelrich, J. and da Costa Avelar, P.H. and Tsoka, S. and Bullinger, L. and Seubert, E. and Smit, D.J. and Bokemeyer, C. and Ackermann, C. and Wellbrock, J. and Haag, F. and Fiedler, W.
Journal for ImmunoTherapy of Cancer 10 (12): e004794. 22 December 2022

Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.
Fernandez Lahore, R.G. and Pampaloni, N.P. and Peter, E. and Heim, M.M. and Tillert, L. and Vierock, J. and Oppermann, J. and Walther, J. and Schmitz, D. and Owald, D. and Plested, A.J.R. and Rost, B.R. and Hegemann, P.
Nature Communications 13 (1): 7844. 21 December 2022

Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host.
Midha, A. and Jarquín-Díaz, V.H. and Ebner, F. and Löber, U. and Hayani, R. and Kundik, A. and Cardilli, A. and Heitlinger, E. and Forslund, S.K. and Hartmann, S.
Microbiome 10 (1): 229. 16 December 2022

Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A. and Sprink, T. and Noel, J.K. and Vázquez-Sarandeses, E. and van Hoorn, C. and Mohd, S. and Loerke, J. and Spahn, C.M.T. and Daumke, O.
Nature Communications 13 (1): 7641. 10 December 2022

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M. and Zywitza, V. and Naitou, Y. and Hamazaki, N. and Goeritz, F. and Hermes, R. and Holtze, S. and Lazzari, G. and Galli, C. and Stejskal, J. and Diecke, S. and Hildebrandt, T.B. and Hayashi, K.
Science Advances 8 (49): eabp9683. 9 December 2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M. and Mücke, M.B. and Pallien, T. and Markó, L. and Sholokh, A. and Schächterle, C. and Aydin, A. and Kidd, A. and Walter, S. and Esmati, Y. and McMurray, B.J. and Lato, D.F. and Sunaga-Franze, D.Y. and Dierks, P.H. and Flores, B.I.M. and Walker-Gray, R. and Gong, M. and Merticariu, C. and Zühlke, K. and Russwurm, M. and Liu, T. and Batolomaeus, T.U.P. and Pautz, S. and Schelenz, S. and Taube, M. and Napieczynska, H. and Heuser, A. and Eichhorst, J. and Lehmann, M. and Miller, D.C. and Diecke, S. and Qadri, F. and Popova, E. and Langanki, R. and Movsesian, M.A. and Herberg, F.W. and Forslund, S.K. and Müller, D.N. and Borodina, T. and Maass, P.G. and Bähring, S. and Hübner, N. and Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments.
Ruscheweyh, H.J. and Milanese, A. and Paoli, L. and Karcher, N. and Clayssen, Q. and Keller, M.I. and Wirbel, J. and Bork, P. and Mende, D.R. and Zeller, G. and Sunagawa, S.
Microbiome 10 (1): 212. 5 December 2022

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Widjaja, A.A. and Viswanathan, S. and Shekeran, S.G. and Adami, E. and Lim, W.W. and Chothani, S. and Tan, J. and Goh, J.W.T. and Chen, H.M. and Lim, S.Y. and Boustany-Kari, C.M. and Hawkins, J. and Petretto, E. and Hübner, N. and Schafer, S. and Coffman, T.M. and Cook, S.A.
Nature Communications 13 (1): 7497. 5 December 2022

Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J. and Jerke, U. and Eulenberg-Gustavus, C. and Kling, L. and Jenne, D.E. and Kirchner, M. and Mertins, P. and Bieringer, M. and Elitok, S. and Eckardt, K.U. and Schreiber, A. and Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132 (23): e160089. 1 December 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K. and Obermayer, B. and Mache, C. and Fathykova, D. and Kessler, M. and Dökel, S. and Wyler, E. and Baumgardt, M. and Löwa, A. and Hoffmann, K. and Graff, P. and Schulze, J. and Mieth, M. and Hellwig, K. and Demir, Z. and Biere, B. and Brunotte, L. and Mecate-Zambrano, A. and Bushe, J. and Dohmen, M. and Hinze, C. and Elezkurtaj, S. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Schmidt-Ott, K.M. and Busch, J. and Klauschen, F. and Horst, D. and Radbruch, H. and Radke, J. and Heppner, F. and Corman, V.M. and Niemeyer, D. and Müller, M.A. and Goffinet, C. and Mothes, R. and Pascual-Reguant, A. and Hauser, A.E. and Beule, D. and Landthaler, M. and Ludwig, S. and Suttorp, N. and Witzenrath, M. and Gruber, A.D. and Drosten, C. and Sander, L.E. and Wolff, T. and Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
Bahry, E. and Breimann, L. and Zouinkhi, M. and Epstein, L. and Kolyvanov, K. and Mamrak, N. and King, B. and Long, Xi and Harrington, K.I.S. and Lionnet, T. and Preibisch, S.
Nature Methods 19 (12): 1563-1567. December 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D. and Ambrozkiewicz, M.C. and Zinnall, U. and Rusanova, A. and Borisova, E. and Drescher, A.N. and Couce-Iglesias, M. and Villamil, G. and Dannenberg, R. and Imami, K. and Münster-Wandowski, A. and Fauler, B. and Mielke, T. and Selbach, M. and Landthaler, M. and Spahn, C.M.T. and Tarabykin, V. and Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J. and Bartolomaeus, H. and Löber, U. and Behrens, F. and Bartolomaeus, T.U.P. and Anandakumar, H. and Wimmer, M. and Vu, D.L. and Kuhring, M. and Brüning, U. and Maifeld, A. and Geisberger, S. and Kempa, S. and Schumacher, F. and Kleuser, B. and Bufler, P. and Querfeld, U. and Kitschke, S. and Engler, D. and Kuhrt, L.D. and Drechsel, O. and Eckardt, K.U. and Forslund, S. and Thürmer, A. and McParland, V. and Kirwan, J. and Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J. and Kim, S.J. and Skopnik, C.M. and Hinze, C. and Boltengagen, A. and Metzke, D. and Grothgar, E. and Prskalo, L. and Wagner, L. and Freund, P. and Görlich, N. and Muench, F. and Schmidt-Ott, K.M. and Mashreghi, M.F. and Kocks, C. and Eckardt, K.U. and Rajewsky, N. and Enghard, P.
Kidney International 102 (6): 1359-1370. December 2022

Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease.
Pichler, R. and Rizzo, L. and Tröndle, K. and Bühler, M. and Brucker, H. and Müller, A.L. and Grand, K. and Farè, S. and Viau, A. and Kaminski, M.M. and Kuehn, E.W. and Koch, F. and Zimmermann, S. and Koltay, P. and Lienkamp, S.S.
Biomaterials 291 : 121910. December 2022

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, S. and Hurdiss, D.L. and Walser, M. and Malvezzi, F. and Mayor, J. and Ryter, S. and Moreno, H. and Liechti, N. and Bosshart, A. and Iss, C. and Calabro, V. and Cornelius, A. and Hospodarsch, T. and Neculcea, A. and Looser, T. and Schlegel, A. and Fontaine, S. and Villemagne, D. and Paladino, M. and Schiegg, D. and Mangold, S. and Reichen, C. and Radom, F. and Kaufmann, Y. and Schaible, D. and Schlegel, I. and Zitt, C. and Sigrist, G. and Straumann, M. and Wolter, J. and Comby, M. and Sacarcelik, F. and Drulyte, I. and Lyoo, H. and Wang, C. and Li, W. and Du, W. and Binz, H.K. and Herrup, R. and Lusvarghi, S. and Neerukonda, S.N. and Vassell, R. and Wang, W. and Adler, J.M. and Eschke, K. and Nascimento, M. and Abdelgawad, A. and Gruber, A.D. and Bushe, J. and Kershaw, O. and Knutson, C.G. and Balavenkatraman, K.K. and Ramanathan, K. and Wyler, E. and Teixeira Alves, L.G. and Lewis, S. and Watson, R. and Haeuptle, M.A. and Zürcher, A. and Dawson, K.M. and Steiner, D. and Weiss, C.D. and Amstutz, P. and van Kuppeveld, F.J.M. and Stumpp, M.T. and Bosch, B.J. and Engler, O. and Trimpert, J.
Nature Biotechnology 40 (12): 1845-1854. December 2022

Cell type diversity in a developing octopus brain.
Styfhals, R. and Zolotarov, G. and Hulselmans, G. and Spanier, K.I. and Poovathingal, S. and Elagoz, A.M. and De Winter, S. and Deryckere, A. and Rajewsky, N. and Ponte, G. and Fiorito, G. and Aerts, S. and Seuntjens, E.
Nature Communications 13 (1): 7392. 30 November 2022

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F. and Bjordahl, R. and Goodridge, J.P. and Mahmood, S. and Gaidarova, S. and Abujarour, R. and Davis, Z.B. and Merino, A. and Tuininga, K. and Wang, H. and Kumar, A. and Groff, B. and Witty, A. and Bonello, G. and Huffman, J. and Dailey, T. and Lee, T.T. and Malmberg, K.J. and Walcheck, B. and Höpken, U. and Rehm, A. and Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

DNA methylation-based classification of sinonasal tumors.
Jurmeister, P. and Glöß, S. and Roller, R. and Leitheiser, M. and Schmid, S. and Mochmann, L.H. and Payá Capilla, E. and Fritz, R. and Dittmayer, C. and Friedrich, C. and Thieme, A. and Keyl, P. and Jarosch, A. and Schallenberg, S. and Bläker, H. and Hoffmann, I. and Vollbrecht, C. and Lehmann, A. and Hummel, M. and Heim, D. and Haji, M. and Harter, P. and Englert, B. and Frank, S. and Hench, J. and Paulus, W. and Hasselblatt, M. and Hartmann, W. and Dohmen, H. and Keber, U. and Jank, P. and Denkert, C. and Stadelmann, C. and Bremmer, F. and Richter, A. and Wefers, A. and Ribbat-Idel, J. and Perner, S. and Idel, C. and Chiariotti, L. and Della Monica, R. and Marinelli, A. and Schüller, U. and Bockmayr, M. and Liu, J. and Lund, V.J. and Forster, M. and Lechner, M. and Lorenzo-Guerra, S.L. and Hermsen, M. and Johann, P.D. and Agaimy, A. and Seegerer, P. and Koch, A. and Heppner, F. and Pfister, S.M. and Jones, D.T.W. and Sill, M. and von Deimling, A. and Snuderl, M. and Müller, K.R. and Forgó, E. and Howitt, B.E. and Mertins, P. and Klauschen, F. and Capper, D.
Nature Communications 13 (1): 7148. 28 November 2022

MicroRNAs are deeply linked to the emergence of the complex octopus brain.
Zolotarov, G. and Fromm, B. and Legnini, I. and Ayoub, S. and Polese, G. and Maselli, V. and Chabot, P.J. and Vinther, J. and Styfhals, R. and Seuntjens, E. and Di Cosmo, A. and Peterson, K.J. and Rajewsky, N.
Science Advances 8 (47): eadd9938. 25 November 2022

Non-redundant functions of group 2 innate lymphoid cells.
Jarick, K.J. and Topczewska, P.M. and Jakob, M.O. and Yano, H. and Arifuzzaman, M. and Gao, X. and Boulekou, S. and Stokic-Trtica, V. and Leclère, P.S. and Preußer, A. and Rompe, Z.A. and Stamm, A. and Tsou, A.M. and Chu, C. and Heinrich, F.R. and Guerra, G.M. and Durek, P. and Ivanov, A. and Beule, D. and Helfrich, S. and Duerr, C.U. and Kühl, A.A. and Stehle, C. and Romagnani, C. and Mashreghi, M.F. and Diefenbach, A. and Artis, D. and Klose, C.S.N.
Nature 611 (7937): 794-800. 24 November 2022

Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M. and Chao, C.C. and Wang, Y.C. and Kenison, J.E. and Li, Z. and Rone, J.M. and Rejano-Gordillo, C.M. and Polonio, C.M. and Gutierrez-Vazquez, C. and Piester, G. and Plasencia, A. and Li, L. and Giovannoni, F. and Lee, H.G. and Faust Akl, C. and Wheeler, M.A. and Mascanfroni, I. and Jaronen, M. and Alsuwailm, M. and Hewson, P. and Yeste, A. and Andersen, B.M. and Franks, D.G. and Huang, C.J. and Ekwudo, M. and Tjon, E.C. and Rothhammer, V. and Takenaka, M. and de Lima, K.A. and Linnerbauer, M. and Guo, L. and Covacu, R. and Queva, H. and Fonseca-Castro, P.H. and Bladi, M.A. and Cox, L.M. and Hodgetts, K.J. and Hahn, M.E. and Mildner, A. and Korzenik, J. and Hauser, R. and Snapper, S.B. and Quintana, F.J.
Nature 611 (7937): 801-809. 24 November 2022

Semi-automated assembly of high-quality diploid human reference genomes.
Jarvis, E.D. and Formenti, G. and Rhie, A. and Guarracino, A. and Yang, C. and Wood, J. and Tracey, A. and Thibaud-Nissen, F. and Vollger, M.R. and Porubsky, D. and Cheng, H. and Asri, M. and Logsdon, G.A. and Carnevali, P. and Chaisson, M.J.P. and Chin, C.S. and Cody, S. and Collins, J. and Ebert, P. and Escalona, M. and Fedrigo, O. and Fulton, R.S. and Fulton, L.L. and Garg, S. and Gerton, J.L. and Ghurye, J. and Granat, A. and Green, R.E. and Harvey, W. and Hasenfeld, P. and Hastie, A. and Haukness, M. and Jaeger, E.B. and Jain, M. and Kirsche, M. and Kolmogorov, M. and Korbel, J.O. and Koren, S. and Korlach, J. and Lee, J. and Li, D. and Lindsay, T. and Lucas, J. and Luo, F. and Marschall, T. and Mitchell, M.W. and McDaniel, J. and Nie, F. and Olsen, H.E. and Olson, N.D. and Pesout, T. and Potapova, T. and Puiu, D. and Regier, A. and Ruan, J. and Salzberg, S.L. and Sanders, A.D. and Schatz, M.C. and Schmitt, A. and Schneider, V.A. and Selvaraj, S. and Shafin, K. and Shumate, A. and Stitziel, N.O. and Stober, C. and Torrance, J. and Wagner, J. and Wang, J. and Wenger, A. and Xiao, C. and Zimin, A.V. and Zhang, G. and Wang, T. and Li, H. and Garrison, E. and Haussler, D. and Hall, I. and Zook, J.M. and Eichler, E.E. and Phillippy, A.M. and Paten, B. and Howe, K. and Miga, K.H.
Nature 611 (7936): 519-531. 17 November 2022

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L. and Petkovic, M. and Watkins, T.B.K. and Colliver, E.C. and Laskina, S. and Thapa, N. and Minussi, D.C. and Navin, N. and Swanton, C. and Van Loo, P. and Haase, K. and Tarabichi, M. and Schwarz, R.F.
Genome Biology 23 (1): 241. 14 November 2022

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.
Boix, O. and Martinez, M. and Vidal, S. and Giménez-Alejandre, M. and Palenzuela, L. and Lorenzo-Sanz, L. and Quevedo, L. and Moscoso, O. and Ruiz-Orera, J. and Ximénez-Embún, P. and Ciriaco, N. and Nuciforo, P. and Stephan-Otto Attolini, C. and Albà, M.M. and Muñoz, J. and Tian, T.V. and Varela, I. and Vivancos, A. and Ramón Y Cajal, S. and Muñoz, P. and Rivas, C. and Abad, M.
Nature Communications 13 (1): 6840. 11 November 2022

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S. and Company, C. and Song, K. and Lowenstein, E.D. and Riedel, L. and Birchmeier, C. and Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Belda, E. and Voland, L. and Tremaroli, V. and Falony, G. and Adriouch, S. and Assmann, K.E. and Prifiti, E. and Aron-Wisnewsky, J. and Debédat, J. and Le Roy, T. and Nielsen, T. and Amouyal, C. and André, S. and Andreelli, F. and Blüher, M. and Chakaroun, R. and Chilloux, J. and Coelho, L.P. and Dao, M.C. and Das, P. and Fellahi, S. and Forslund, S. and Galleron, N. and Hansen, T.H. and Holmes, B. and Ji, B. and Krogh Pedersen, H. and Le, P. and Le Chatelier, E. and Lewinter, C. and Mannerås-Holm, L. and Marquet, F. and Myridakis, A. and Pelloux, V. and Pons, N. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Sokolovska, N. and Søndertoft, N.B. and Touch, S. and Vieira-Silva, S. and Galan, P. and Holst, J. and Gøtze, J.P. and Køber, L. and Vestergaard, H. and Hansen, T. and Hercberg, S. and Oppert, J.M. and Nielsen, J. and Letunic, I. and Dumas, M.E. and Stumvoll, M. and Pedersen, O.B. and Bork, P. and Ehrlich, S.D. and Zucker, J.D. and Bäckhed, F. and Raes, J. and Clément, K.
Gut 71 (12): 2463-2480. 7 November 2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B. and Lazarow, K. and Kolesnichenko, M. and Sporbert, A. and von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A. and Bunse, M. and Joedicke, J.J. and Blanc, E. and Gudipati, V. and Moles, M.W. and Shiku, H. and Beule, D. and Huppa, J.B. and Höpken, U.E. and Rehm, A.
Molecular Therapy 30 (11): 3358-3378. 2 November 2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S. and Müllerke, S. and Arnold, A. and Heuberger, J. and Berger, H. and Lin, M. and Mollenkopf, H.J. and Wizenty, J. and Horst, D. and Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Antibiotic resistance genes in river biofilms: a metagenomic approach toward the identification of sources and candidate hosts.
Kneis, D. and Berendonk, T.U. and Forslund, S.K. and Hess, S.
Environmental Science and Technology 56 (21): 14913-14922. 1 November 2022

Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C. and Lammoglia Cobo, M.F. and Stein, C.A. and Hsu, M.T. and Ben Hamza, A. and Penter, L. and Chen, X. and Buccitelli, C. and Popp, O. and Mertins, P. and Dietze, K. and Bullinger, L. and Moosmann, A. and Blanc, E. and Beule, D. and Gerbitz, A. and Strobel, J. and Hackstein, H. and Rahn, H.P. and Dornmair, K. and Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10 (11): 1407-1419. 1 November 2022

The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K. and Kirchner, M. and Mertins, P. and Zuberbier, T. and Babina, M.
Allergy 77 (11): 3337-3349. November 2022

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L. and Luebeck, J. and Dehkordi, S.R. and Colón, C.I. and Li, R. and Wong, I.T.L. and Coruh, C. and Dharanipragada, P. and Lomeli, S.H. and Weiser, N.E. and Moriceau, G. and Zhang, X. and Bailey, C. and Houlahan, K.E. and Yang, W. and González, R.C. and Swanton, C. and Curtis, C. and Jamal-Hanjani, M. and Henssen, A.G. and Law, J.A. and Greenleaf, W.J. and Lo, R.S. and Mischel, P.S. and Bafna, V. and Chang, H.Y.
Nature Genetics 54 (11): 1746–1754. November 2022

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B. and Marenholz, I. and Jeanrenaud, A.C.S.N. and Meixner, L. and Arnau-Soler, A. and Rosillo-Salazar, O.D. and Ghauri, A. and Cibin, P. and Blümchen, K. and Schlags, R. and Hansen, G. and Seidenberg, J. and Keil, T. and Lau, S. and Niggemann, B. and Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 150 (5): 1125-1134. November 2022

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
Rückert, T. and Lareau, C.A. and Mashreghi, M.F. and Ludwig, L.S. and Romagnani, C.
Nature Immunology 23 (11): 1551-1563. November 2022

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten and Belhaj, S. and Tawalbeh, E. and Nagels, D. and Fröhlich, Y. and Finzer, P. and Ciruela, P. and Sabrià, A. and Herrero, M. and Andrés, C. and Antón, A. and Benmoumene, A. and Asskali, D. and Haidar, H. and von Dahlen, J. and Nicolai, J. and Stiller, M. and Blum, J. and Lange, C. and Adelmann, C. and Schroer, B. and Osmers, U. and Grice, C. and Kirfel, P.P. and Jomaa, H. and Strelow, D. and Hülse, L. and Pigulla, M. and Kreuzer, P. and Tyshaieva, A. and Weber, J. and Wienemann, T. and Kohns Vasconcelos, M. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Scholz, C.J. and Jazmati, N. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Ehlkes, L. and Walker, A. and Dilthey, A.T.
Eurosurveillance 27 (43): 2101089. 27 October 2022

H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L. and Papafotiou, G. and Popp, O. and Mertins, P. and Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10 (10): e005535. 27 October 2022

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E. and Bagley, D.C. and Hernandez, V.L. and Roberts, L.B. and Maguire, T.J.A. and Voss, F. and Mertins, P. and Kirchner, M. and Peset-Martin, I. and Woszczek, G. and Rosenblatt, J. and Gotthardt, M. and Santis, G. and Parsons, M.
Nature Communications 13 (1): 6407. 27 October 2022

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann, C. and Spallek, R. and Karpiuk, O. and Heider, M. and Schäffer, I. and Zecha, J. and Klaeger, S. and Walzik, M. and Öllinger, R. and Engleitner, T. and Wirth, M. and Keller, U. and Krönke, J. and Rudelius, M. and Kossatz, S. and Rad, R. and Kuster, B. and Bassermann, F.
EMBO Journal 41 (20): e110871. 17 October 2022

Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C. and Maghsudi, S. and Ohler, U.
Nucleic Acids Research 50 (18): e107. 14 October 2022

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Yanchus, C. and Drucker, K.L. and Kollmeyer, T.M. and Tsai, R. and Winick-Ng, W. and Liang, M. and Malik, A. and Pawling, J. and De Lorenzo, S.B. and Ali, A. and Decker, P.A. and Kosel, M.L. and Panda, A. and Al-Zahrani, K.N. and Jiang, L. and Browning, J.W.L. and Lowden, C. and Geuenich, M. and Hernandez, J.J. and Gosio, J.T. and Ahmed, M. and Loganathan, S.K. and Berman, J. and Trcka, D. and Michealraj, K.A. and Fortin, J. and Carson, B. and Hollingsworth, E.W. and Jacinto, S. and Mazrooei, P. and Zhou, L. and Elia, A. and Lupien, M. and He, H.H. and Murphy, D.J. and Wang, L. and Abyzov, A. and Dennis, J.W. and Maass, P.G. and Campbell, K. and Wilson, M.D. and Lachance, D.H. and Wrensch, M. and Wiencke, J. and Mak, T. and Pennacchio, L.A. and Dickel, D.E. and Visel, A. and Wrana, J. and Taylor, M.D. and Zadeh, G. and Dirks, P. and Eckel-Passow, J.E. and Attisano, L. and Pombo, A. and Ida, C.M. and Kvon, E.Z. and Jenkins, R.B. and Schramek, D.
Science 378 (6615): 68-78. 7 October 2022

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana, S. and Kretschmer, S. and Hunger, S. and Yan, X. and Kuster, D. and Traikov, S. and Zillinger, T. and Gentzel, M. and Elangovan, S. and Dasgupta, P. and Chappidi, N. and Lucas, N. and Maser, K.I. and Maatz, H. and Rapp, A. and Marchand, V. and Chang, Y.T. and Motorin, Y. and Hubner, N. and Hartmann, G. and Hyman, A.A. and Alberti, S. and Lee-Kirsch, M.A.
Molecular Cell 82 (19): 3712-3728.e10. 6 October 2022

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto, M. and Kaminski, M.M. and Adrianus, C. and Kim, N. and Greensmith, R. and Dissanayake-Perera, S. and Schubert, A.J. and Tan, X. and Kim, H. and Dighe, A.S. and Collins, J.J. and Stevens, M.M.
Nature Nanotechnology 17 (10): 1120-1126. October 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T. and Rose, J.C. and Chen, C.Y. and Pichugin, Y. and Xie, L. and Tang, J. and Hung, K.L. and Yost, K.E. and Shi, Q. and Erb, M.L. and Rajkumar, U. and Wu, S. and Taschner-Mandl, S. and Bernkopf, M. and Swanton, C. and Liu, Z. and Huang, W. and Chang, H.Y. and Bafna, V. and Henssen, A.G. and Werner, B. and Mischel, P.S.
Nature Genetics 54 (10): 1527-1533. October 2022

Best practice standards for circular RNA research.
Nielsen, A.F. and Bindereif, A. and Bozzoni, I. and Hanan, M. and Hansen, T.B. and Irimia, M. and Kadener, S. and Kristensen, L.S. and Legnini, I. and Morlando, M. and Jarlstad Olesen, M.T. and Pasterkamp, R.J. and Preibisch, S. and Rajewsky, N. and Suenkel, C. and Kjems, J.
Nature Methods 19 (10): 1208-1220. October 2022

Framework and baseline examination of the German National Cohort (NAKO).
Peters, A. and Peters, A. and Greiser, K.H. and Göttlicher, S. and Ahrens, W. and Albrecht, M. and Bamberg, F. and Bärnighausen, T. and Becher, H. and Berger, K. and Beule, A. and Boeing, H. and Bohn, B. and Bohnert, K. and Braun, B. and Brenner, H. and Bülow, R. and Castell, S. and Damms-Machado, A. and Dörr, M. and Ebert, N. and Ecker, M. and Emmel, C. and Fischer, B. and Franzke, C.W. and Gastell, S. and Giani, G. and Günther, M. and Günther, K. and Günther, K.P. and Haerting, J. and Haug, U. and Heid, I.M. and Heier, M. and Heinemeyer, D. and Hendel, T. and Herbolsheimer, F. and Hirsch, J. and Hoffmann, W. and Holleczek, B. and Hölling, H. and Hörlein, A. and Jöckel, K.H. and Kaaks, R. and Karch, A. and Karrasch, S. and Kartschmit, N. and Kauczor, H.U. and Keil, T. and Kemmling, Y. and Klee, B. and Klüppelholz, B. and Kluttig, A. and Kofink, L. and Köttgen, A. and Kraft, D. and Krause, G. and Kretz, L. and Krist, L. and Kühnisch, J. and Kuß, O. and Legath, N. and Lehnich, A.T. and Leitzmann, M. and Lieb, W. and Linseisen, J. and Loeffler, M. and Macdonald, A. and Maier-Hein, K.H. and Mangold, N. and Meinke-Franze, C. and Meisinger, C. and Melzer, J. and Mergarten, B. and Michels, K.B. and Mikolajczyk, R. and Moebus, S. and Mueller, U. and Nauck, M. and Niendorf, T. and Nikolaou, K. and Obi, N. and Ostrzinski, S. and Panreck, L. and Pigeot, I. and Pischon, T. and Pschibul-Thamm, I. and Rathmann, W. and Reineke, A. and Roloff, S. and Rujescu, D. and Rupf, S. and Sander, O. and Schikowski, T. and Schipf, S. and Schirmacher, P. and Schlett, C.L. and Schmidt, B. and Schmidt, G. and Schmidt, M. and Schöne, G. and Schulz, H. and Schulze, M.B. and Schweig, A. and Sedlmeier, A.M. and Selder, S. and Six-Merker, J. and Sowade, R. and Stang, A. and Stegle, O. and Steindorf, K. and Stübs, G. and Swart, E. and Teismann, H. and Thiele, I. and Thierry, S. and Ueffing, M. and Völzke, H. and Waniek, S. and Weber, A. and Werner, N. and Wichmann, H.E. and Willich, S.N. and Wirkner, K. and Wolf, K. and Wolff, R. and Zeeb, H. and Zinkhan, M. and Zschocke, J.
European Journal of Epidemiology 37 (10): 1107-1124. October 2022

A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T.I. and Prigione, A. and Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39 (10): msac175. October 2022

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel, A.R. and Szabo, Q. and Chiariello, A.M. and Chudzik, K. and Schöpflin, R. and Rothe, P. and Mattei, A.L. and Zehnder, To. and Harnett, D. and Laupert, V. and Bianco, S. and Hetzel, S. and Glaser, J. and Phan, M.H.Q. and Schindler, M. and Ibrahim, D.M. and Paliou, C. and Esposito, A. and Prada-Medina, C.A. and Haas, S.A. and Giere, P. and Vingron, M. and Wittler, L. and Meissner, A. and Nicodemi, M. and Cavalli, G. and Bantignies, F. and Mundlos, S. and Robson, M.I.
Cell 185 (20): 3689-3704. 29 September 2022

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I. and Seeger, T. and Bruyneel, A.A.N. and Termglinchan, V. and Monte, E. and Lim, E.W. and Vadgama, N. and Furihata, T. and Gavidia, A.A. and Arthur Ataam, J. and Bharucha, N. and Martinez-Amador, N. and Ameen, M. and Nair, P. and Serrano, R. and Kaur, B. and Feyen, D.A.M. and Diecke, S. and Snyder, M.P. and Metallo, C.M. and Mercola, M. and Karakikes, I.
European Heart Journal 43 (36): 3477-3489. 21 September 2022

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G. and Vanzo, R. and Amitash, S. and Martín-Doncel, E. and Coscia, F. and Mund, A. and Lerdrup, M. and Benada, J. and Boos, D. and Toledo, L.
Molecular Cell 82 (18): 3350-3365. 15 September 2022

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
Poetz, F. and Lebedeva, S. and Schott, J. and Lindner, D. and Ohler, U. and Stoecklin, G.
Genome Biology 23 (1): 193. 12 September 2022

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R. and Rautenstrauch, P. and Ghanbari, M. and James, A.R. and Kirchler, M. and Ohler, U. and Konigorski, S. and Lippert, C.
Nature Communications 13 (1): 5332. 10 September 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. and Kocks, C. and Leiz, J. and Karaiskos, N. and Boltengagen, A. and Cao, S. and Skopnik, C.M. and Klocke, J. and Hardenberg, J.H. and Stockmann, H. and Gotthardt, I. and Obermayer, B. and Haghverdi, L. and Wyler, E. and Landthaler, M. and Bachmann, S. and Hocke, A.C. and Corman, V. and Busch, J. and Schneider, W. and Himmerkus, N. and Bleich, M. and Eckardt, K.U. and Enghard, P. and Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M. and Foglierini, M. and Khorkova, S. and Vázquez García, C. and Ratswohl, C. and Davydov, A.N. and Turchaninova, M.A. and Daubenberger, C. and Chudakov, D.M. and Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T. and Funck, K. and Wollweber, F. and Lisicki, E. and von der Malsburg, K. and von der Malsburg, A. and Laborenz, J. and Noel, J.K. and Hessenberger, M. and Jungbluth, S. and Bernert, C. and Kunz, S. and Riedel, D. and Lilie, H. and Jakobs, S. and van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D. and Borsa, M. and Puleston, D.J. and Zellner, S. and Capera, J. and Sanderson, S. and Schifferer, M. and Hester, S.S. and Ge, X. and Fischer, R. and Jostins, L. and Behrends, C. and Alsaleh, G. and Simon, A.K.
Nature Communications 13 (1): 5174. 2 September 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. and Obermayer, B. and Weiner, J.M. and Zimmermann, K. and Anania, C. and Wagner, L.K. and Lyras, E.M. and Sapozhnikova, V. and Lara-Astiaso, D. and Prósper, F. and Lang, R. and Lupiáñez, D.G. and Beule, D. and Höpken, U.E. and Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J. and Berangi, M. and Yiannakou, C. and Silva, E. and Francischello, R. and Kuehne, A. and Niendorf, T. and Könneker, S. and Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15 : 382-391. September 2022

Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N. and Jahn, E. and Saadati, M. and Bullinger, L. and Larson, R.A. and Ottone, T. and Amadori, S. and Prior, T.W. and Brandwein, J.M. and Appelbaum, F.R. and Medeiros, B.C. and Tallman, M.S. and Ehninger, G. and Heuser, M. and Ganser, A. and Pallaud, C. and Gathmann, I. and Krzykalla, J. and Benner, A. and Bloomfield, C.D. and Thiede, C. and Stone, R.M. and Döhner, H. and Döhner, K.
Leukemia 36 (9): 2218-2227. September 2022

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L. and Braun, J. and Fauchere, F. and Vanshylla, K. and Loyal, L. and Henze, L. and Kruse, B. and Dingeldey, M. and Jürchott, K. and Mangold, M. and Maraj, A. and Braginets, A. and Böttcher, C. and Nitsche, A. and de la Rosa, K. and Ratswohl, C. and Sawitzki, B. and Holenya, P. and Reimer, U. and Sander, L.E. and Klein, F. and Paul, F. and Bellmann-Strobl, J. and Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Drivers and determinants of strain dynamics following fecal microbiota transplantation.
Schmidt, T.S.B. and Li, S.S. and Maistrenko, O.M. and Akanni, W. and Coelho, L.P. and Dolai, S. and Fullam, A. and Glazek, A.M. and Hercog, R. and Herrema, H. and Jung, F. and Kandels, S. and Orakov, A. and Thielemann, R. and von Stetten, M. and Van Rossum, T. and Benes, V. and Borody, T.J. and de Vos, W.M. and Ponsioen, C.Y. and Nieuwdorp, M. and Bork, P.
Nature Medicine 28 (9): 1902-1912. September 2022

Mutations in TAF8 cause a neurodegenerative disorder.
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PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
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ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.
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The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019.
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Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.
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Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.
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Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
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A high-resolution map of human RNA translation.
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Molecular Cell 82 (15): 2885-2899.e8. 4 August 2022

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
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EMBO Molecular Medicine : e15687. 2 August 2022

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
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Haematologica 107 (8): 1758-1772. August 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
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Nature Genetics 54 (8): 1227-1237. August 2022

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
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Haematologica 107 (8): 1773-1785. August 2022

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
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Science Advances 8 (33): eabk2814. August 2022

Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
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Journal of the American Society of Nephrology 33 (8): 1528-1545. August 2022

Deep Visual Proteomics defines single-cell identity and heterogeneity.
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Nature Biotechnology 40 (8): 1231-1240. August 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
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CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
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Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
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The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
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Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
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Nature Communications 13 (1): 4297. 25 July 2022

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
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Nature Communications 13 (1): 4070. 13 July 2022

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja, A. and Wakimoto, H. and DeLaughter, D.M. and Reichart, D. and Gorham, J. and Conner, D.A. and Lun, M. and Probst, C.K. and Sakai, N. and Knipe, R.S. and Montesi, S.B. and Shea, B. and Adam, L.P. and Leinwand, L.A. and Wan, W. and Choi, E.S. and Lindberg, E.L. and Patone, G. and Noseda, M. and Hübner, N. and Seidman, C.E. and Tager, A.M. and Seidman, J.G. and Ho, C.Y.
Proceedings of the National Academy of Sciences of the United States of America 119 (28): e2204174119. 12 July 2022

Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
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Nature Communications 13 (1): 3934. 8 July 2022

Biosynthetic potential of the global ocean microbiome.
Paoli, L. and Ruscheweyh, H.J. and Forneris, C.C. and Hubrich, F. and Kautsar, S. and Bhushan, A. and Lotti, A. and Clayssen, Q. and Salazar, G. and Milanese, A. and Carlström, C.I. and Papadopoulou, C. and Gehrig, D. and Karasikov, M. and Mustafa, H. and Larralde, M. and Carroll, L.M. and Sánchez, P. and Zayed, A.A. and Cronin, D.R. and Acinas, S.G. and Bork, P. and Bowler, C. and Delmont, T.O. and Gasol, J.M. and Gossert, A.D. and Kahles, A. and Sullivan, M.B. and Wincker, P. and Zeller, G. and Robinson, S.L. and Piel, J. and Sunagawa, S.
Nature 607 (7917): 111-118. 7 July 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J. and Müllerke, S. and Kolesnichenko, M. and Heuberger, J. and Lin, M. and Fischer, A.S. and Mollenkopf, H.J. and Berger, H. and Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
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Nature Genetics July 2022

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
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Nature Genetics 54 (7): 1037-1050. July 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.
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Nature Neuroscience 25 (7): 944-955. July 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
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Molecular Cancer 21 (1): 126. 10 June 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
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Science Advances 8 (23): eabl5162. 8 June 2022

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal, E. and Schmidt, T.S.B. and Molina-Montes, E. and Rodríguez-Perales, S. and Wirbel, J. and Maistrenko, O.M. and Akanni, W.A. and Alashkar Alhamwe, B. and Alves, R.J. and Carrato, A. and Erasmus, H.P. and Estudillo, L. and Finkelmeier, F. and Fullam, A. and Glazek, A.M. and Gómez-Rubio, P. and Hercog, R. and Jung, F. and Kandels, S. and Kersting, S. and Langheinrich, M. and Márquez, M. and Molero, X. and Orakov, A. and Van Rossum, T. and Torres-Ruiz, R. and Telzerow, A. and Zych, K. and Benes, V. and Zeller, G. and Trebicka, J. and Real, F.X. and Malats, N. and Bork, P.
Gut 71 (7): 1359-1372. 7 June 2022

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L. and Dempsey, B. and Garancher, A. and Bourane, S. and Ruffault, P.L. and Morin-Surun, M.P. and Rocques, N. and Goulding, M. and Eychène, A. and Pouponnot, C. and Fortin, G. and Champagnat, J.
Nature Communications 13 (1): 3284. 7 June 2022

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
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Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
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Science Advances 8 (22): eabm9106. 3 June 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
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Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
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Nature Communications 13 (1): 3059. 1 June 2022

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
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A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
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Nature Metabolism 4 (6): 672-682. June 2022

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.
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Nature Cancer 3 (6): 696-709. June 2022

Proton-gated anion transport governs macropinosome shrinkage.
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Nature Cell Biology 24 (6): 885-895. June 2022

Identifying tumor cells at the single-cell level using machine learning.
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Genome Biology 23 (1): 123. 30 May 2022

Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma.
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Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
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Science Advances 8 (21): eabl5032. 27 May 2022

Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
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Cell 185 (11): 1986-2005. 26 May 2022

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical tTrial.
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Serotonin limits generation of chromaffin cells during adrenal organ development.
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Nature Communications 13 (1): 2901. 25 May 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
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Nature Communications 13 (1): 2727. 18 May 2022

Brain-wide interactions during hippocampal sharp wave ripples.
Nitzan, N. and Swanson, R. and Schmitz, D. and Buzsáki, G.
Proceedings of the National Academy of Sciences of the United States of America 119 (20): e2200931119. 17 May 2022

The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.
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Journal for ImmunoTherapy of Cancer 10 (5): e004475. 17 May 2022

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
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Journal of Clinical Investigation 132 (10): e148333. 16 May 2022

The genomic and transcriptional landscape of primary central nervous system lymphoma.
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Nature Communications 13 (1): 2558. 10 May 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
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Cell Stem Cell 29 (5): 760-775. 5 May 2022

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
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Molecular Therapy 30 (5): 1952-1965. 4 May 2022

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
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Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation.
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Nature Cell Biology 24 (5): 633-644. May 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
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Nature Cancer 3 (4): 471-485. 28 April 2022

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1.
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Blood 139 (16): 2534-2546. 21 April 2022

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S. and Smyshlyaev, G. and Letunic, I. and Maistrenko, O.M. and Coelho, L.P. and Orakov, A. and Forslund, S.K. and Hildebrand, F. and Luetge, M. and Schmidt, T.S.B. and Barabas, O. and Bork, P.
Nucleic Acids Research 50 (6): 3155-3168. 8 April 2022

Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T. and Himmerkus, N. and Meoli, L. and Fromm, A. and Sewerin, S. and Kriuchkova, N. and Nagel, O. and Ladilov, Y. and Krug, S. and Quintanova, C. and Stumpp, M. and Garbe-Schönberg, D. and Westernströer, U. and Merkel, C. and Brinkhus, M. and Altmüller, J. and Schweiger, M. and Mueller, D. and Mutig, K. and Morawski, M. and Halbritter, J. and Milatz, S. and Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33 (4): 699-717. April 2022

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
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Statistical analysis in the German National Cohort (NAKO) - specific aspects and general recommendations.
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European Journal of Epidemiology 37 (4): 429-436. April 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
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Gastroenterology 162 (4): 1067-1087. April 2022

A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome.
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Journal of the American Society of Nephrology 33 (4): 718-730. April 2022

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
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Cell 185 (7): 1130-1142.e11. 31 March 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
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Nature Communications 13 (1): 1577. 24 March 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G. and Conlon, T.M. and Jeridi, A. and Kim, R. and Ertüz, Z. and Lang, N.J. and Ansari, M. and Novikova, M. and Jiang, D. and Strunz, M. and Gaianova, M. and Hollauer, C. and Gabriel, C. and Angelidis, I. and Doll, S. and Pestoni, J.C. and Edelmann, S.L. and Kohlhepp, M.S. and Guillot, A. and Bassler, K. and Van Eeckhoutte, H.P. and Kayalar, Ö. and Konyalilar, N. and Kanashova, T. and Rodius, S. and Ballester-López, C. and Genes Robles, C.M. and Smirnova, N. and Rehberg, M. and Agarwal, C. and Krikki, I. and Piavaux, B. and Verleden, S.E. and Vanaudenaerde, B. and Königshoff, M. and Dittmar, G. and Bracke, K.R. and Schultze, J.L. and Watz, H. and Eickelberg, O. and Stoeger, T. and Burgstaller, G. and Tacke, F. and Heissmeyer, V. and Rinkevich, Y. and Bayram, H. and Schiller, H.B. and Conrad, M. and Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O. and Halpert, G. and Schimke, L.F. and Ostrinski, Y. and Vojdani, A. and Baiocchi, G.C. and Freire, P.P. and Filgueiras, I.S. and Zyskind, I. and Lattin, M.T. and Tran, F. and Schreiber, S. and Marques, A.H.C. and Plaça, D.R. and Fonseca, D.L.M. and Humrich, J.Y. and Müller, A. and Giil, L.M. and Graßhoff, H. and Schumann, A. and Hackel, A. and Junker, J. and Meyer, C. and Ochs, H.D. and Lavi, Y.B. and Scheibenbogen, C. and Dechend, R. and Jurisica, I. and Schulze-Forster, K. and Silverberg, J.I. and Amital, H. and Zimmerman, J. and Heidecke, H. and Rosenberg, A.Z. and Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13 (1): 1220. 9 March 2022

Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly.
Li, H. and Janssens, J. and De Waegeneer, M. and Kolluru, S.S. and Davie, K. and Gardeux, V. and Saelens, W. and David, F.P.A. and Brbić, M. and Spanier, K. and Leskovec, J. and McLaughlin, C.N. and Xie, Q. and Jones, R.C. and Brueckner, K. and Shim, J. and Tattikota, S.G. and Schnorrer, F. and Rust, K. and Nystul, T.G. and Carvalho-Santos, Zi. and Ribeiro, C. and Pal, S. and Mahadevaraju, S. and Przytycka, T.M. and Allen, A.M. and Goodwin, S.F. and Berry, C.W. and Fuller, M.T. and White-Cooper, H. and Matunis, E.L. and DiNardo, S. and Galenza, A. and O'Brien, L.E. and Dow, J.A.T. and Jasper, H. and Oliver, B. and Perrimon, N. and Deplancke, B. and Quake, S.R. and Luo, L. and Aerts, S.
Science 375 (6584): eabk2432. 4 March 2022

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M. and von Arx, A.S. and Cruz-Ochoa, N. and Dawson, K. and Ivanov, A. and Mueller, F.S. and Lin, H.Y. and Amport, R. and Mildenberger, W. and Mattei, D. and Beule, D. and Földy, C. and Greter, M. and Notter, T. and Meyer, U.
Science Advances 8 (9): eabi6672. 4 March 2022

Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M. and Yu, H. and Yu, X. and Liang, S. and Hu, Y. and Luo, Y. and Izsvák, Z. and Sun, C. and Wang, J.
Cell Stem Cell 29 (3): 400-418.e13. 3 March 2022

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J. and Bamopoulos, S.A. and Köse, H. and Orben, F. and Zang, C. and Pons, M. and den Dekker, A.T. and Brouwer, R.W.W. and Baluapuri, A. and Habringer, S. and Reichert, M. and Illendula, A. and Krämer, O.H. and Schick, M. and Wolf, E. and van IJcken, W.F.J. and Esposito, I. and Keller, U. and Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119 (9): e2105691119. 1 March 2022

Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
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Nature Biotechnology 40 (3): 374-381. March 2022

Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T. and Zhang, Y. and Vadas, O. and Roske, Y. and Gulluni, F. and De Santis, M.C. and Zagar, A.V. and Stephanowitz, H. and Hirsch, E. and Liu, F. and Daumke, O. and Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29 (3): 218-228. March 2022

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić, S. and Prada-Medina, C.A. and Landoulsi, Z. and Ghelfi, J. and Delcambre, S. and Dietrich, C. and Jarazo, J. and Henck, J. and Balachandran, S. and Pachchek, S. and Morris, C.M. and Antony, P. and Timmermann, B. and Sauer, S. and Pereira, S.L. and Schwamborn, J.C. and May, P. and Grünewald, A. and Spielmann, M.
Brain 145 (3): 964-978. March 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S. and Busch, C.J.L. and Molawi, K. and Geirsdottir, L. and Maurizio, J. and Vargas Aguilar, S. and Belahbib, H. and Gimenez, G. and Yuda, R.A.A. and Burkon, M. and Favret, J. and Gholamhosseinian Najjar, S. and de Laval, B. and Kandalla, P.K. and Sarrazin, S. and Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23 (3): 458-468. March 2022

A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.
Shahan, R. and Hsu, C.W. and Nolan, T.M. and Cole, B.J. and Taylor, I.W. and Greenstreet, L. and Zhang, S. and Afanassiev, A. and Vlot, A.H.C. and Schiebinger, G. and Benfey, P.N. and Ohler, U.
Developmental Cell 57 (4): 543-560. 28 February 2022

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.
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Nature Biotechnology 40 (7): 1030-1034. 24 February 2022

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
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Nature Communications 13 (1): 1009. 23 February 2022

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
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Nature Communications 13 (1): 1018. 23 February 2022

Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
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Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
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Clinical and Translational Medicine 12 (2): e726. 20 February 2022

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
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Science 375 (6582): 782-787. 18 February 2022

Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
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New England Journal of Medicine 386 (7): 629-639. 17 February 2022

Microbiome and metabolome features of the cardiometabolic disease spectrum.
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Nature Medicine 28 (2): 303-314. 17 February 2022

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
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Blood 139 (7): 1080-1097. 17 February 2022

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia, A. and Zimmermann, F. and Schumann, P. and Jasina, A. and Roessler, J. and Schmidt, D. and Heinze, P. and Kaisler, J. and Nageswaran, V. and Aigner, A. and Ceglarek, U. and Cineus, R. and Hegazy, A.N. and van der Vorst, E.P.C. and Döring, Y. and Strauch, C.M. and Nemet, I. and Tremaroli, V. and Dwibedi, C. and Kränkel, N. and Leistner, D.M. and Heimesaat, M.M. and Bereswill, S. and Rauch, G. and Seeland, U. and Soehnlein, O. and Müller, D.N. and Gold, R. and Bäckhed, F. and Hazen, S.L. and Haghikia, A. and Landmesser, U.
European Heart Journal 43 (6): ehab644. 7 February 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
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Cell 185 (3): 493-512. 3 February 2022

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
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Cell Stem Cell 29 (2): 265-280. 3 February 2022

Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
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Environmental Health Perspectives 130 (2): 27003. 3 February 2022

Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C. and Polovitskaya, M.M. and Delgado, B.D. and Jentsch, T.J. and Long, S.B.
Science Advances 8 (5): eabm3942. 2 February 2022

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
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Biological Reviews 97 (1): 115-140. February 2022

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W. and Akalin, A. and Ohler, U.
Nature Machine Intelligence 4 (2): 162-168. February 2022

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
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Nature Medicine 28 (2): 295-302. February 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E. and Brückner, L. and Henssen, A.G.
Nature Genetics 54 (2): 107-114. February 2022

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
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Blood 139 (4): 538-553. 27 January 2022

Towards the biogeography of prokaryotic genes.
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Nature 601 (7892): 252-256. 13 January 2022

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Schick, M. and Zhang, L. and Maurer, S. and Maurer, H.C. and Isaakaidis, K. and Schneider, L. and Patra, U. and Schunck, K. and Rohleder, E. and Hofstetter, J. and Baluapuri, A. and Scherger, A.K. and Slotta-Huspenina, J. and Hettler, F. and Weber, J. and Engleitner, T. and Maresch, R. and Slawska, J. and Lewis, R. and Istvanffy, R. and Habringer, S. and Steiger, K. and Baiker, A. and Oostendorp, R.A.J. and Miething, C. and Lenhof, H.P. and Bassermann, F. and Chapuy, B. and Wirth, M. and Wolf, E. and Rad, R. and Müller, S. and Keller, U.
Nature Communications 13 (1): 281. 12 January 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R. and Aronsen, J.M. and Bergan-Dahl, A. and Moutty, M.C. and Lunde, M. and Lunde, P.K. and Jarstadmarken, H. and Wanichawan, P. and Pereira, L. and Kolstad, T.R.S. and Dalhus, B. and Subramanian, H. and Hille, S. and Christensen, G. and Müller, O.J. and Nikolaev, V. and Bers, D.M. and Sjaastad, I. and Shen, X. and Louch, W.E. and Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
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Science Advances 8 (1): eabg9471. 7 January 2022

Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
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Circulation Research 130 (1): 67-79. 7 January 2022

A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.
Patsalos, A. and Halasz, L. and Medina-Serpas, M.A. and Berger, W.K. and Daniel, B. and Tzerpos, P. and Kiss, M. and Nagy, G. and Fischer, C. and Simandi, Z. and Varga, T. and Nagy, L.
Journal of Experimental Medicine 219 (1): e20210420. 3 January 2022

Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
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Leukemia 36 (1): 90-99. January 2022

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
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Cell 184 (26): 6243-6261. 22 December 2021

Extracellular matrix in heart Failure: role of ADAMTS5 in proteoglycan remodeling.
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Circulation 144 (25): 2021-2034. 21 December 2021

Deep tissue scattering compensation with three-photon F-SHARP.
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Optica 8 (12): 1613-1619. 20 December 2021

Combinatorial, additive and dose-dependent drug-microbiome associations.
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Nature 600 : 500-505. 16 December 2021

CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N. and Eckstein, J. and Wallach, I. and Nordmeyer, S. and Kelm, M. and Kirchner, M. and Goubergrits, L. and Schafstedde, M. and Hennemuth, A. and Kraus, M. and Grune, T. and Mertins, P. and Kuehne, T. and Holzhütter, H.G.
Circulation 144 (24): 1926-1939. 14 December 2021

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F. and Corbo, J. and Levdansky, Y. and Spiegelhalter, A. and Lindner, D. and Magg, V. and Lebedeva, S. and Schweiggert, J. and Schott, J. and Valkov, E. and Stoecklin, G.
Nature Communications 12 (1): 7175. 9 December 2021

The SEQC2 epigenomics quality control (EpiQC) study.
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Genome Biology 22 (1): 332. 6 December 2021

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.
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Nucleic Acids Research 49 (21): 12178-12195. 2 December 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
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Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
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Gut 70 (12): 2330-2336. December 2021

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
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Haematologica 106 (12): 3100-3106. December 2021

Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L. and Gohil, S.H. and Lareau, C. and Ludwig, L.S. and Parry, E.M. and Huang, T. and Li, S. and Zhang, W. and Livitz, D. and Leshchiner, I. and Parida, L. and Getz, G. and Rassenti, L.Z. and Kipps, T.J. and Brown, J.R. and Davids, M.S. and Neuberg, D.S. and Livak, K.J. and Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11 (12): 3048-3063. December 2021

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H. and Badillo-Lisakowski, V. and Britto-Borges, T. and Kubli, D.A. and Jüttner, R. and Parakkat, P. and Lopez Carballo, J. and Hüttemeister, J. and Liss, M. and Hansen, A. and Dieterich, C. and Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13 (622): eabe8952. December 2021

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Rosswog, C. and Bartenhagen, C. and Welte, A. and Kahlert, Y. and Hemstedt, N. and Lorenz, W. and Cartolano, M. and Ackermann, S. and Perner, S. and Vogel, W. and Altmüller, J. and Nürnberg, P. and Hertwig, F. and Göhring, G. and Lilienweiss, E. and Stütz, A.M. and Korbel, J.O. and Thomas, R.K. and Peifer, M. and Fischer, M.
Nature Genetics 53 (12): 1673–1685. December 2021

Compendium of 530 metagenome-assembled bacterial and archaeal genomes from the polar Arctic Ocean.
Royo-Llonch, M. and Sánchez, P. and Ruiz-González, C. and Salazar, G. and Pedrós-Alió, C. and Sebastián, M. and Labadie, K. and Paoli, L. and M. Ibarbalz, F. and Zinger, L. and Churcheward, B. and Chaffron, S. and Eveillard, D. and Karsenti, E. and Sunagawa, S. and Wincker, P. and Karp-Boss, L. and Bowler, C. and Acinas, S.G.
Nature Microbiology 6 (12): 1561-1574. December 2021

Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T. and Kedziora, S.M. and Haase, N. and Herse, F. and Alenina, N. and Müller, D.N. and Bader, M. and Schupp, M. and Dechend, R. and Golic, M. and Kräker, K.
Diabetologia 64 (12): 2829-2842. December 2021

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S. and Vonficht, D. and Jopp-Saile, L. and Raffel, S. and Lutz, R. and Leonce, D. and Antes, M. and Hernández-Malmierca, P. and Ordoñez-Rueda, D. and Ramasz, B. and Boch, T. and Jann, J.C. and Nowak, D. and Hofmann, W.K. and Müller-Tidow, C. and Hübschmann, D. and Alexandrov, T. and Benes, V. and Trumpp, A. and Paulsen, M. and Velten, L. and Haas, S.
Nature Immunology 22 (12): 1577-1589. December 2021

Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W. and Kukalev, A. and Harabula, I. and Zea-Redondo, L. and Szabó, D. and Meijer, M. and Serebreni, L. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Irastorza-Azcarate, I. and Thieme, C.J. and Sparks, T.M. and Carvalho, S. and Fiorillo, L. and Musella, F. and Irani, E. and Triglia, E.T. and Kolodziejczyk, A.A. and Abentung, A. and Apostolova, G. and Paul, E.J. and Franke, V. and Kempfer, R. and Akalin, A. and Teichmann, S.A. and Dechant, G. and Ungless, M.A. and Nicodemi, M. and Welch, L. and Castelo-Branco, G. and Pombo, A.
Nature 599 (7886): 684-691. 25 November 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K. and Toedling, J. and Huska, M. and Cwikla, M.C. and Kruetzfeldt, L.M. and Proba, J. and Ambros, P.F. and Ambros, I.M. and Boral, S. and Lodrini, M. and Chen, C.Y. and Burkert, M. and Guergen, D. and Szymansky, A. and Astrahantseff, K. and Kuenkele, A. and Haase, K. and Fischer, M. and Deubzer, H.E. and Hertwig, F. and Hundsdoerfer, P. and Henssen, A.G. and Schwarz, R.F. and Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
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Nature Communications 12 (1): 6618. 16 November 2021

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10 (1): 2151-2168. 16 November 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B. and Knoll, R. and Bonaguro, L. and ToVinh, M. and Raabe, J. and Astaburuaga-García, R. and Schulte-Schrepping, J. and Kaiser, K.M. and Rieke, G.J. and Bischoff, J. and Monin, M.B. and Hoffmeister, C. and Schlabe, S. and De Domenico, E. and Reusch, N. and Händler, K. and Reynolds, G. and Blüthgen, N. and Hack, G. and Finnemann, C. and Nischalke, H.D. and Strassburg, C.P. and Stephenson, E. and Su, Y. and Gardner, L. and Yuan, D. and Chen, D. and Goldman, J. and Rosenstiel, P. and Schmidt, S.V. and Latz, E. and Hrusovsky, K. and Ball, A.J. and Johnson, J.M. and Koenig, P.A. and Schmidt, F.I. and Haniffa, M. and Heath, J.R. and Kümmerer, B.M. and Keitel, V. and Jensen, B. and Stubbemann, P. and Kurth, F. and Sander, L.E. and Sawitzki, B. and Aschenbrenner, A.C. and Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K. and Teranishi, K. and Ambroso, M.R. and Isas, J.M. and Vazquez-Sarandeses, E. and Lee, J.Y. and Melo, A.A. and Pandey, P. and Merken, D. and Berndt, L. and Lammers, M. and Daumke, O. and Chang, K. and Haworth, I.S. and Langen, R.
Nature Communications 12 (1): 6466. 9 November 2021

Unravelling the collateral damage of antibiotics on gut bacteria.
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Nature 599 : 120-124. 4 November 2021

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A. and Gärtner, A. and Cyganek, L. and Tiburcy, M. and Tuleta, I. and Wellers, L. and Folsche, L. and Hobbach, A.J. and von Frieling-Salewsky, M. and Unger, A. and Hucke, A. and Koser, F. and Kassner, A. and Sielemann, K. and Streckfuß-Bömeke, K. and Hasenfuss, G. and Goedel, A. and Laugwitz, K.L. and Moretti, A. and Gummert, J.F. and Dos Remedios, C.G. and Reinecke, H. and Knöll, R. and van Heesch, S. and Hubner, N. and Zimmermann, W.H. and Milting, H. and Linke, W.A.
Science Translational Medicine 13 (618): eabd3079. 3 November 2021

A medullary centre for lapping in mice.
Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
Nature Communications 12 : 6307. 2 November 2021

Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures.
Kreye, J. and Wright, S.K. and van Casteren, A. and Stoeffler, L. and Machule, M.L. and Reincke, S.M. and Nikolaus, M. and van Hoof, S. and Sanchez-Sendin, E. and Homeyer, M.A. and Gómez, C.C. and Kornau, H.C. and Schmitz, D. and Kaindl, A.M. and Boehm-Sturm, P. and Mueller, S. and Wilson, M.A. and Upadhya, M.A. and Dhangar, D.R. and Greenhill, S. and Woodhall, G. and Turko, P. and Vida, I. and Garner, C.C. and Wickel, J. and Geis, C. and Fukata, Y. and Fukata, M. and Prüss, H.
Journal of Experimental Medicine 218 (11): e20210012. 1 November 2021

Reporting guidelines for human microbiome research: the STORMS checklist.
Mirzayi, C. and Renson, A. and Zohra, F. and Elsafoury, S. and Geistlinger, L. and Kasselman, L.J. and Eckenrode, K. and van de Wijgert, J. and Loughman, A. and Marques, F.Z. and MacIntyre, D.A. and Arumugam, M. and Azhar, R. and Beghini, F. and Bergstrom, K. and Bhatt, A. and Bisanz, J.E. and Braun, J. and Bravo, H.C. and Buck, G.A. and Bushman, F. and Casero, D. and Clarke, G. and Collado, M.C. and Cotter, P.D. and Cryan, J.F. and Demmer, R.T. and Devkota, S. and Elinav, E. and Escobar, J.S. and Fettweis, J. and Finn, R.D. and Fodor, A.A. and Forslund, S. and Franke, A. and Furlanello, C. and Gilbert, J. and Grice, E. and Haibe-Kains, B. and Handley, S. and Herd, P. and Holmes, S. and Jacobs, J.P. and Karstens, L. and Knight, R. and Knights, D. and Koren, O. and Kwon, D.S. and Langille, M. and Lindsay, B. and McGovern, D. and McHardy, A.C. and McWeeney, S. and Mueller, N.T. and Nezi, L. and Olm, M. and Palm, N. and Pasolli, E. and Raes, J. and Redinbo, M.R. and Rühlemann, M. and Balfour Sartor, R and Schloss, P.D. and Schriml, L. and Segal, E. and Shardell, M. and Sharpton, T. and Smirnova, E. and Sokol, H. and Sonnenburg, J.L. and Srinivasan, S. and Thingholm, L.B. and Turnbaugh, P.J. and Upadhyay, V. and Walls, R.L. and Wilmes, P. and Yamada, T. and Zeller, G. and Zhang, M. and Zhao, N. and Zhao, L. and Bao, W. and Culhane, A. and Devanarayan, V. and Dopazo, J. and Fan, X. and Fischer, M. and Jones, W. and Kusko, R. and Mason, C.E. and Mercer, T.R. and Sansone, S.A. and Scherer, A. and Shi, L. and Thakkar, S. and Tong, W. and Wolfinger, R. and Hunter, C. and Segata, N. and Huttenhower, C. and Dowd, J.B. and Jones, H.E. and Waldron, L.
Nature Medicine 27 (11): 1885-1892. November 2021

Cannabidiol converts NF(κ)B into a tumor suppressor in glioblastoma with defined antioxidative properties.
Volmar, M.N.M. and Cheng, J. and Alenezi, H. and Richter, S. and Haug, A. and Hassan, Z. and Goldberg, M. and Li, Y. and Hou, M. and Herold-Mende, C. and Maire, C.L. and Lamszus, K. and Flüh, C. and Held-Feindt, J. and Gargiulo, G. and Topping, G.J. and Schilling, F. and Saur, D. and Schneider, G. and Synowitz, M. and Schick, J.A. and Kälin, R.E. and Glass, R.
Neuro-Oncology 23 (11): 1898-1910. November 2021

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M. and Franke, V. and Bruno, M. and Grishkovskaya, I. and Kasiliauskaite, A. and Kaufmann, T. and Schoeberl, U.E. and Puchinger, M.G. and Kostrhon, S. and Ebenwaldner, C. and Sebesta, M. and Beltzung, E. and Mechtler, K. and Lin, G. and Vlasova, A. and Leeb, M. and Pavri, R. and Stark, A. and Akalin, A. and Stefl, R. and Bernecky, C. and Djinovic-Carugo, K. and Slade, D.
Nature Communications 12 (1): 6078. 19 October 2021

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O. and Nehls, N. and Prexler, C. and von Heyking, K. and Groll, T. and Pardon, K. and Garcia, H.D. and Hensel, T. and Gürgen, D. and Henssen, A.G. and Eggert, A. and Steiger, K. and Burdach, S. and Richter, G.H.S.
Journal of Experimental & Clinical Cancer Research 40 (1): 322. 15 October 2021

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S. and Koch, K. and Schriever, C. and Xu, J. and Steinecker, M. and Leber, J. and Dworatzek, E. and Purfürst, B. and Kunz, S. and Recchia, D. and Canepari, M. and Heuser, A. and Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12 : 1249-1265. 14 October 2021

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Brial, F. and Chilloux, J. and Nielsen, T. and Vieira-Silva, S. and Falony, G. and Andrikopoulos, P. and Olanipekun, M. and Hoyles, L. and Djouadi, F. and Neves, A.L. and Rodriguez-Martinez, A. and Mouawad, G.I. and Pons, N. and Forslund, S. and Le-Chatelier, E. and Le Lay, A. and Nicholson, J. and Hansen, T. and Hyötyläinen, T. and Clément, K. and Oresic, M. and Bork, P. and Ehrlich, S.D. and Raes, J. and Pedersen, O.B. and Gauguier, D. and Dumas, M.E.
Gut 70 (11): 2105-2114. 7 October 2021

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. and Bischoff, P. and Peidli, S. and Sieber, A. and Trinks, A. and Lüthen, M. and Obermayer, B. and Blanc, E. and Ruchiy, Y. and Sell, T. and Mamlouk, S. and Arsie, R. and Wei, T.T. and Klotz-Noack, K. and Schwarz, R.F. and Sawitzki, B. and Kamphues, C. and Beule, D. and Landthaler, M. and Sers, C. and Horst, D. and Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13 (10): e14123. 7 October 2021

Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
Gebert, J. and Gelincik, O. and Oezcan-Wahlbrink, M. and Marshall, J.D. and Hernandez-Sanchez, A. and Urban, K. and Long, M. and Cortes, E. and Tosti, E. and Katzenmaier, E.M. and Song, Y. and Elsaadi, A. and Deng, N. and Vilar, E. and Fuchs, V. and Nelius, N. and Yuan, Y.P. and Ahadova, A. and Sei, S. and Shoemaker, R.H. and Umar, A. and Wei, L. and Liu, S. and Bork, P. and Edelmann, W. and von Knebel Doeberitz, M. and Lipkin, S.M. and Kloor, M.
Gastroenterology 161 (4): 288-1302.e13. October 2021

Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta, S. and Short, S.A.P. and Sise, M.E. and Prosek, J.M. and Madhavan, S.M. and Soler, M.J. and Ostermann, M. and Herrmann, S.M. and Abudayyeh, A. and Anand, S. and Glezerman, I. and Motwani, S.S. and Murakami, N. and Wanchoo, R. and Ortiz-Melo, D.I. and Rashidi, A. and Sprangers, B. and Aggarwal, V. and Malik, A.B. and Loew, S. and Carlos, C.A. and Chang, W.T. and Beckerman, P. and Mithani, Z. and Shah, C.V. and Renaghan, A.D. and Seigneux, S.D. and Campedel, L. and Kitchlu, A. and Shin, D.S. and Rangarajan, S. and Deshpande, P. and Coppock, G. and Eijgelsheim, M. and Seethapathy, H. and Lee, M.D. and Strohbehn, I.A. and Owen, D.H. and Husain, M. and Garcia-Carro, C. and Bermejo, S. and Lumlertgul, N. and Seylanova, N. and Flanders, L. and Isik, B. and Mamlouk, O. and Lin, J.S. and Garcia, P. and Kaghazchi, A. and Khanin, Y. and Kansal, S.K. and Wauters, E. and Chandra, S. and Schmidt-Ott, K.M. and Hsu, R.K. and Tio, M.C. and Sarvode Mothi, S. and Singh, H. and Schrag, D. and Jhaveri, K.D. and Reynolds, K.L. and Cortazar, F.B. and Leaf, D.E.
Journal for ImmunoTherapy of Cancer 9 (10): e003467. October 2021

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K. and Kaljunen, H. and Taavitsainen, S. and Kaarijärvi, R. and Järvelä, E. and Rodriguez Martin, B. and Haase, K. and Woodcock, D.J. and Tubio, J. and Wedge, D.C. and Nykter, M. and Bova, G.S.
Cancer Research 81 (19): 4901-4909. October 2021

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.
Lewis, R. and Maurer, H.C. and Singh, N. and Gonzalez-Menendez, I. and Wirth, M. and Schick, M. and Zhang, L. and Isaakidis, K. and Scherger, A.K. and Schulze, V. and Lu, J. and Zenz, T. and Steiger, K. and Rad, R. and Quintanilla-Martinez, L. and Espeli, M. and Balabanian, K. and Keller, U. and Habringer, S.
Leukemia 35 : 2895-2905. October 2021

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
Mimitou, E.P. and Lareau, C.A. and Chen, K.Y. and Zorzetto-Fernandes, A.L. and Hao, Y. and Takeshima, Y. and Luo, W. and Huang, T.S. and Yeung, B.Z. and Papalexi, E. and Thakore, P.I. and Kibayashi, T. and Wing, J.B. and Hata, M. and Satija, R. and Nazor, K.L. and Sakaguchi, S. and Ludwig, L.S. and Sankaran, V.G. and Regev, A. and Smibert, P.
Nature Biotechnology 39 (10): 1246-1258. October 2021

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.
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Nature Cell Biology 23 (10): 1073-1084. October 2021

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
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Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response.
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Using DNA sequencing data to quantify T cell fraction and therapy response.
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Nature 597 (7877): 555-560. 23 September 2021

Bioaccumulation of therapeutic drugs by human gut bacteria.
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Nature 597 : 533-538. 23 September 2021

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
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Nature Communications 12 (1): 5577. 22 September 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
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Nature Communications 12 (1): 5505. 17 September 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
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Nature Communications 12 (1): 5395. 13 September 2021

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
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Nature Communications 12 (1): 5415. 13 September 2021

Locus specific epigenetic modalities of random allelic expression imbalance.
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Nature Communications 12 (1): 5330. 9 September 2021

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
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EMBO Molecular Medicine 13 (9): e14365. 7 September 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
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Nature 597 (7874): 87-91. 2 September 2021

NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport.
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Nature Protocols 16 (9): 4177-4200. September 2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
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Nature Communications 12 (1): 5056. 20 August 2021

A simple pressure-assisted method for MicroED specimen preparation.
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Nature Communications 12 (1): 5036. 19 August 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
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Nature Communications 12 (1): 4869. 11 August 2021

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
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Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
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Nature Communications 12 (1): 4801. 10 August 2021

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
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American Journal of Human Genetics 108 (8): 1450-1465. 5 August 2021

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
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Cell Stem Cell 28 (8): 1473-1482. 5 August 2021

Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
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Nature Ecology & Evolution 5 : 1135–1144. August 2021

High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
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Journal for ImmunoTherapy of Cancer 9 (7): e002410. 30 July 2021

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P. and Song, T. and Yao, Y. and Fehlner-Peach, H. and Diamond, B. and Gu, H. and Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118 (30): e2100576118. 27 July 2021

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M. and Vancraenenbroeck, R. and Rosenblum, G. and Hofmann, H. and Mikhailov, A.S. and Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2101144118. 13 July 2021

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
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Circulation 144 (2): 144-158. 13 July 2021

Skin sodium is increased in male patients with multiple sclerosis and related animal models.
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Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2102549118. 13 July 2021

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.
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Cell 184 (14): 3660-3673. 8 July 2021

CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
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Nature Genetics 53 (7): 1064-1074. July 2021

Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp.
Joh, H.K. and Lee, D.H. and Hur, J. and Nimptsch, K. and Chang, Y. and Joung, H. and Zhang, X. and Rezende, L.F.M. and Lee, J.E. and Ng, K. and Chen, Y. and Tabung, F.K. and Meyerhardt, J.A. and Chan, A.T. and Pischon, T. and Song, M. and Fuchs, C.S. and Willett, W.C. and Cao, Y. and Ogino, S. and Giovannucci, E. and Wu, K.
Gastroenterology 161 (1): 128-142. July 2021

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
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Genome Biology 22 (1): 191. 28 June 2021

Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J. and Luxán, G. and Abplanalp, W.T. and Glaser, S.F. and Rasper, T. and Fischer, A. and Muhly-Reinholz, M. and Potente, M. and Assmus, B. and John, D. and Zeiher, A.M. and Dimmeler, S.
Nature Communications 12 (1): 3964. 25 June 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
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Nature Communications 12 (1): 3818. 21 June 2021

Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F. and Gossmann, T.I. and Frioux, C. and Özkurt, E. and Myers, P.N. and Ferretti, P. and Kuhn, M. and Bahram, M. and Nielsen, H.B. and Bork, P.
Cell Host & Microbe 29 (7): 1167-1176. 14 June 2021

GUNC: detection of chimerism and contamination in prokaryotic genomes.
Orakov, A. and Fullam, A. and Coelho, L.P. and Khedkar, S. and Szklarczyk, D. and Mende, D.R. and Schmidt, T.S.B. and Bork, P.
Genome Biology 22 (1): 178. 13 June 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C. and Schallenberg, S. and Kirchner, M. and Ziehm, M. and Niquet, S. and Haji, M. and Beier, C. and Neudecker, J. and Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren, A.A. and Snellings, D.A. and Su, Y.S. and Hong, C.C. and Castro, M. and Tang, A.T. and Detter, M.R. and Hobson, N. and Girard, R. and Romanos, S. and Lightle, R. and Moore, T. and Shenkar, R. and Benavides, C. and Beaman, M.M. and Mueller-Fielitz, H. and Chen, M. and Mericko, P. and Yang, J. and Sung, D.C. and Lawton, M.T. and Ruppert, M. and Schwaninger, M. and Körbelin, J. and Potente, M. and Awad, I.A. and Marchuk, D.A. and Kahn, M.L.
Nature 594 (7862): :271-276. 10 June 2021

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S. and Schultze, H. and Shastry, K.L. and Manamohan, S. and Mukherjee, S. and Garg, V. and Sarveswara, R. and Händler, K. and Pickkers, P. and Aziz, N.A. and Ktena, S. and Tran, F. and Bitzer, M. and Ossowski, S. and Casadei, N. and Herr, C. and Petersheim, D. and Behrends, U. and Kern, F. and Fehlmann, T. and Schommers, P. and Lehmann, C. and Augustin, M. and Rybniker, J. and Altmüller, J. and Mishra, N. and Bernardes, J.P. and Krämer, B. and Bonaguro, L. and Schulte-Schrepping, J. and De Domenico, E. and Siever, C. and Kraut, M. and Desai, M. and Monnet, B. and Saridaki, M. and Siegel, C.M. and Drews, A. and Nuesch-Germano, M. and Theis, H. and Heyckendorf, J. and Schreiber, S. and Kim-Hellmuth, S. and Nattermann, J. and Skowasch, D. and Kurth, I. and Keller, A. and Bals, R. and Nürnberg, P. and Rieß, O. and Rosenstiel, P. and Netea, M.G. and Theis, F. and Mukherjee, S. and Backes, M. and Aschenbrenner, A.C. and Ulas, T. and Breteler, M.M.B. and Giamarellos-Bourboulis, E.J. and Kox, M. and Becker, M. and Cheran, S. and Woodacre, M.S. and Goh, E.L. and Schultze, J.L.
Nature 594 (7862): 265-270. 10 June 2021

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M. and Gmach, P. and Boltz, H.H. and Einsiedel, J. and Gotthardt, M. and Hübner, H. and Gmeiner, P. and Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
Cuello, F. and Knaust, A.E. and Saleem, U. and Loos, M. and Raabe, J. and Mosqueira, D. and Laufer, S. and Schweizer, M. and Kraak, P. and Flenner, F. and Ulmer, B.M and Braren, I. and Yin, X. and Theofilatos, K. and Ruiz-Orera, J. and Patone, G. and Klampe, B. and Schulze, T. and Piasecki, A. and Pinto, Y. and Vink, A. and Hübner, N. and Harding, S. and Mayr, M. and Denning, C. and Eschenhagen, T. and Hansen, A.
EMBO Molecular Medicine 13 (6): e13074. 7 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
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Blood 137 (22): 3093-3104. 3 June 2021

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M. and Saraswat, M. and Bessière, C. and Menichelli, C. and Ramilowski, J.A. and Severin, J. and Hayashizaki, Y. and Itoh, M. and Tagami, M. and Murata, M. and Kojima-Ishiyama, M. and Noma, S. and Noguchi, S. and Kasukawa, T. and Hasegawa, A. and Suzuki, H. and Nishiyori-Sueki, H. and Frith, M.C. and Chatelain, C. and Carninci, P. and de Hoon, M.J.L. and Wasserman, W.W. and Bréhélin, L. and Lecellier, C.H.
Nature Communications 12 (1): 3297. 2 June 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort.
Birukov, A. and Andersen, L.B. and Andersen, M.S. and Nielsen, J.H. and Nielsen, F.g and Kyhl, H.B. and Jørgensen, J.S. and Grandjean, P. and Dechend, R. and Jensen, T.K.
Environment International 151 : 106442. June 2021

Sodium and its manifold impact on our immune system.
Jobin, K. and Müller, D.N. and Jantsch, J. and Kurts, C.
Trends in Immunology 42 (6): 469-479. June 2021

PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial.
Kreissl, S. and Goergen, H. and Buehnen, I. and Kobe, C. and Moccia, A. and Greil, R. and Eichenauer, D.A. and Zijlstra, J.M. and Markova, J. and Meissner, J. and Feuring-Buske, M. and Soekler, M. and Beck, H.J. and Willenbacher, W. and Ludwig, W.D. and Pabst, T. and Topp, M.S. and Hitz, F. and Bentz, M. and Keller, U.B. and Kühnhardt, D. and Ostermann, H. and Hertenstein, B. and Aulitzky, W. and Maschmeyer, G. and Vieler, T. and Eich, H. and Baues, C. and Stein, H. and Fuchs, M. and Diehl, V. and Dietlein, M. and Engert, A. and Borchmann, P.
Lancet Haematology 8 (6): e398-e409. June 2021

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A. and Roske, Y. and Yamada, S. and Uehata, T. and Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49 (9): 5369-5381. 21 May 2021

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M. and Schrezenmeier, J.F. and Richter-Pechanska, P. and Dolnik, A. and Hick, T.P. and Schleich, K. and Cai, X. and Fan, D.N.Y. and Lohneis, P. and Masswig, S. and Denker, S. and Busse, A. and Knittel, G. and Flümann, R. and Childs, D. and Childs, L. and Gätjens-Sanchez, A.M. and Bullinger, L. and Rosenwald, A. and Reinhardt, H.C. and Schmitt, C.A.
Blood 137 (20): 2785-2899. 20 May 2021

Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin.
Mahn, M. and Saraf-Sinik, I. and Patil, P. and Pulin, M. and Bitton, E. and Karalis, N. and Bruentgens, F. and Palgi, S. and Gat, A. and Dine, J. and Wietek, J. and Davidi, I. and Levy, R. and Litvin, A. and Zhou, F. and Sauter, K. and Soba, P. and Schmitz, D. and Lüthi, A. and Rost, B.R. and Wiegert, J.S. and Yizhar, O.
Neuron 109 (10): 1621-1635. 19 May 2021

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. and Subramaniam, S. and Chomsky-Hecht, O. and Tsemakhovich, V. and Flockerzi, V. and Klussmann, E. and Hirsch, J.A. and Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I. and Holler, K. and Appelbaum, L. and Eisenberg, E. and Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49 (8): 4325-4337. 7 May 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Wilkins, K. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49 (9): 5336-5350. May 2021

Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin.
Fiorillo, L. and Musella, F. and Conte, M. and Kempfer, R. and Chiariello, A.M. and Bianco, S. and Kukalev, A. and Irastorza-Azcarate, I. and Esposito, A. and Abraham, A. and Prisco, A. and Pombo, A. and Nicodemi, M.
Nature Methods 18 (5): 482-490. May 2021

Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K. and Fogo, M.S. and Pinto, B.G.G. and Alves, A.Y. and Suzuki, A.M. and Morales, A.G. and Ezquina, S. and Sosa, O.J. and Sutton, G.J. and Sunaga-Franze, D.Y. and Bueno, A.P. and Seabra, G. and Sardinha, L. and Costa, S.S. and Rosenberg, C. and Zachi, E.C. and Sertie, A.L. and Martins-de-Souza, D. and Reis, E.M. and Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26 (5): 1589-1605. May 2021

Assessing dysferlinopathy patients over three years with a new motor scale.
Jacobs, M. and James, M.K. and Lowes, L.P. and Alfano, L.N. and Eagle, M. and Lofra, R.M. and Moore, U. and Feng, J. and Rufibach, L.E. and Rose, K. and Duong, T. and Bello, L. and Pedrosa-Hernández, I. and Holsten, S. and Sakamoto, C. and Canal, A. and Práxedes, N.S.A. and Thiele, S. and Siener, C. and Vandevelde, B. and DeWolf, B. and Maron, E. and Guglieri, M. and Hogrel, J.Y. and Blamire, A.M. and Carlier, P.G. and Spuler, S. and Day, J.W. and Jones, K.J. and Bharucha-Goebel, D.X. and Salort-Campana, E. and Pestronk, A. and Walter, M.C. and Paradas, C. and Stojkovic, T. and Mori-Yoshimura, M. and Bravver, E. and Díaz-Manera, J. and Pegoraro, E. and Mendell, J.R. and Mayhew, A.G. and Straub, V.
Annals of Neurology 89 (5): 967-978. May 2021

Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E. and Schewe, J. and Zhang, J. and Dinh, H.A. and Forslund, S.K. and Markó, L. and Hellmig, N. and Peters, J. and Muller, D.N. and Lifton, R.P. and Nottoli, T. and Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118 (17): e2014876118. 27 April 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J. and Shi, C. and Costa, A.S.H. and Choi, J. and Kim, J. and Doddaballapur, A. and Sugino, T. and Ong, Y.T. and Castro, M. and Zimmermann, B. and Kaulich, M. and Guenther, S. and Wilhelm, K. and Kubota, Y. and Braun, T. and Koh, G.Y. and Grosso, A.R. and Frezza, C. and Potente, M.
Nature Cell Biology 23 : 413-423. April 2021

SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C. and Günther, U. and Eddison, M. and Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18 : 374-377. April 2021

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K. and Hablesreiter, R. and Inoue, Y. and Yoshida, K. and Briest, F. and Christen, F. and Kakiuchi, N. and Yoshizato, T. and Shiozawa, Y. and Shiraishi, Y. and Striefler, J.K. and Bischoff, S. and Lohneis, P. and Putter, H. and Blau, O. and Keilholz, U. and Bullinger, L. and Pelzer, U. and Hummel, M. and Riess, H. and Ogawa, S. and Sinn, M. and Damm, F.
EBioMedicine 66 : 103327. April 2021

Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens, B. and Schulze, A. and Wysocki, J. and Lin, M.H. and Ye, M. and Kanwar, Y.S. and Bader, M. and Velez, J.C.Q. and Miner, J.H. and Batlle, D.
Kidney International 99 (4): 900-913. April 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 81 (8): 2116-2127. April 2021

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Chen, C.Y. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.
Wirbel, J. and Zych, K. and Essex, M. and Karcher, N. and Kartal, E. and Salazar, G. and Bork, P. and Sunagawa, S. and Zeller, G.
Genome Biology 22 (1): 93. 30 March 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J. and Kownatzki-Danger, D. and Weninger, G. and Seibertz, F. and Pronto, J.R. and Sutanto, H. and Pacheu Grau, D. and Hindmarsh, R. and Brandenburg, S. and Kohl, T. and Hasenfuβ, G. and Gotthardt, M. and Rog-Zielinska, E.A. and Wollnik, B. and Rehling, P. and Urlaub, H. and Wegener, J.W. and Heijman, J. and Voigt, N. and Cyganek, L. and Lenz, C. and Lehnart, S.E.
Circulation Research 128 (6): e102-e120. 19 March 2021

Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge.
Sieberts, S.K. and Schaff, J. and Duda, M. and Pataki, B.Á. and Sun, M. and Snyder, P. and Daneault, J.F. and Parisi, F. and Costante, G. and Rubin, U. and Banda, P. and Chae, Y. and Chaibub Neto, E. and Dorsey, E.R. and Aydın, Z. and Chen, A. and Elo, L.L. and Espino, C. and Glaab, E. and Goan, E. and Golabchi, F.N. and Görmez, Y. and Jaakkola, M.K. and Jonnagaddala, J. and Klén, R. and Li, D. and McDaniel, C. and Perrin, D. and Perumal, T.M. and Rad, N.M. and Rainaldi, E. and Sapienza, S. and Schwab, P. and Shokhirev, N. and Venäläinen, M.S. and Vergara-Diaz, G. and Zhang, Y. and Wang, Y. and Guan, Y. and Brunner, D. and Bonato, P. and Mangravite, L.M. and Omberg, L.
NPJ Digital Medicine 4 (1): 53. 19 March 2021

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M. and Eichner, R. and Stroh, J. and Morath, V. and Kuisl, A. and Zecha, J. and Lawatscheck, J. and Baek, K. and Garz, A.K. and Rudelius, M. and Deuschle, F.C. and Keller, U. and Lemeer, S. and Verbeek, M. and Götze, K.S. and Skerra, A. and Weber, W.A. and Buchner, J. and Schulman, B.A. and Kuster, B. and Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81 (6): 1170-1186. 18 March 2021

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R. and Hilal, T. and Schmidt, S. and Qin, B. and Schwefel, D. and Vieira-Vieira, C.H. and Mielke, T. and Bürger, J. and Loerke, J. and Amikura, K. and Flügel, T. and Ueda, T. and Selbach, M. and Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81 (6): 1200-1215. 18 March 2021

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G. and Altamirano, F. and Kim, S.Y. and Tong, D. and Ferdous, A. and Piristine, H. and Dasgupta, S. and Wang, X. and French, K.M. and Villalobos, E. and Spurgin, S.B. and Waldman, M. and Jiang, N. and May, H.I. and Hill, T.M. and Luo, Y. and Yoo, H. and Zaha, V.G. and Lavandero, S. and Gillette, T.G. and Hill, J.A.
Nature Communications 12 (1): 1684. 16 March 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L. and Jarosch, E. and Zauber, H. and Kniss, A. and Waltho, A. and Bagola, K. and von Delbrück, M. and Löhr, F. and Schulman, B.A. and Selbach, M. and Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A. and Houwaart, T. and Finzer, P. and Ehlkes, L. and Tyshaieva, A. and Damagnez, M. and Strelow, D. and Duplessis, A. and Nicolai, J. and Wienemann, T. and Tamayo, T. and Kohns Vasconcelos, M. and Hülse, L. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Däumer, M.P. and Thielen, A. and Kolbe-Busch, S. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74 (6): 1039-1046. 15 March 2021

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C. and Luecken, M.D. and Eraslan, G. and Sikkema, L. and Waghray, A. and Heimberg, G. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smillie, C. and Jagadeesh, K.A. and Duong, E.T. and Fiskin, E. and Triglia, E.T. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Callori, S. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Cuomo, A.S.E. and Deprez, M. and Duclos, G. and Fine, D. and Fischer, D.S. and Ghazanfar, S. and Gillich, A. and Giotti, B. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Hu, Y. and Jaiswal, A. and Ji, L. and Jiang, P. and Kapellos, T.S. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Ludwig, L.S. and Lukassen, S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Leroy, S. and Mayr, C.H. and Mbano, I.M. and McAdams, A.M. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J.C. and Shea, C.V. and Shi, X. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N.P. and Sountoulidis, A. and Strunz, M. and Sullivan, T.B. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K.A. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Xu, K. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27 (3): 546-559. 2 March 2021

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P. and Birkner, T. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Mähler, A. and Weber, D. and Kochlik, B. and Balogh, A. and Wilck, N. and Boschmann, M. and Müller, D.N. and Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L. and Story, B.A. and Hernández-Malmierca, P. and Raffel, S. and Leonce, D.R. and Milbank, J. and Paulsen, M. and Demir, A. and Szu-Tu, C. and Frömel, R. and Lutz, C. and Nowak, D. and Jann, J.C. and Pabst, C. and Boch, T. and Hofmann, W.K. and Müller-Tidow, C. and Trumpp, A. and Haas, S. and Steinmetz, L.M.
Nature Communications 12 (1): 1366. 1 March 2021

Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C. and Galea, E. and Lakatos, A. and O'Callaghan, J.P. and Petzold, G.C. and Serrano-Pozo, A. and Steinhäuser, C. and Volterra, A. and Carmignoto, G. and Agarwal, A. and Allen, N.J. and Araque, A. and Barbeito, L. and Barzilai, A. and Bergles, D.E. and Bonvento, G. and Butt, A.M. and Chen, W.T. and Cohen-Salmon, M. and Cunningham, C. and Deneen, B. and De Strooper, B. and Díaz-Castro, B. and Farina, C. and Freeman, M. and Gallo, V. and Goldman, J.E. and Goldman, S.A. and Götz, M. and Gutiérrez, A. and Haydon, P.G. and Heiland, D.H. and Hol, E.M. and Holt, M.G. and Iino, M. and Kastanenka, K.V. and Kettenmann, H. and Khakh, B.S. and Koizumi, S. and Lee, C.J. and Liddelow, S.A. and MacVicar, B.A. and Magistretti, P. and Messing, A. and Mishra, A. and Molofsky, A.V. and Murai, K.K. and Norris, C.M. and Okada, S. and Oliet, S.H.R. and Oliveira, J.F. and Panatier, A. and Parpura, V. and Pekna, M. and Pekny, M. and Pellerin, L. and Perea, G. and Pérez-Nievas, B.G. and Pfrieger, F.W. and Poskanzer, K.E. and Quintana, F.J. and Ransohoff, R.M. and Riquelme-Perez, M. and Robel, S. and Rose, C.R. and Rothstein, J.D. and Rouach, N. and Rowitch, D.H. and Semyanov, A. and Sirko, S. and Sontheimer, H. and Swanson, R.A. and Vitorica, J. and Wanner, I.B. and Wood, L.B. and Wu, J. and Zheng, B. and Zimmer, E.R. and Zorec, R. and Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24 (3): 312-325. March 2021

Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A. and Serfling, R. and Möller, J. and Thomas, R. and De Faveri, C. and Zabel, U. and Scarselli, M. and Beck-Sickinger, A.G. and Bock, A. and Coin, I. and Lohse, M.J. and Annibale, P.
Nature Protocols 16 (3): 1419-1451. March 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I. and Poon, E. and Henssen, A.G. and Dorado Garcia, H. and Gatti, M. and Giansanti, C. and Jamin, Y. and Ade, C.P. and Gallant, P. and Schülein-Völk, C. and Beli, P. and Richards, M. and Rosenfeldt, M. and Altmeyer, M. and Anderson, J. and Eggert, A. and Dobbelstein, M. and Bayliss, R. and Chesler, L. and Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. and Company, C. and Dramaretska, Y. and Barozzi, I. and Göhrig, A. and Kertalli, S. and Großmann, M. and Naumann, H. and Sánchez-Bailón, M.P. and Hulsman, D. and Glass, R. and Squatrito, M. and Serresi, M. and Gargiulo, G.
Cancer Discovery 11 (3): 754-777. March 2021

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang, H. and Hooper, C. and Kelly, M. and Steeples, V. and Simon, J.N. and Beglov, J. and Azad, A.J. and Leinhos, L. and Bennett, P. and Ehler, E. and Kalisch-Smith, J.I. and Sparrow, D.B. and Fischer, R. and Heilig, R. and Isackson, H. and Ehsan, M. and Patone, G. and Huebner, N. and Davies, B. and Watkins, H. and Gehmlich, K.
Basic Research in Cardiology 116 (1): 14. 26 February 2021

The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans.
Kazmierczak, M. and Farré i Díaz, C. and Ofenbauer, A. and Herzog, S. and Tursun, B.
Nucleic Acids Research 49 (4): e22. 26 February 2021

CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo.
Martín, A.L. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 49 (4): e19. 26 February 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y. and Lahmann, I. and Baum, K. and Shimojo, H. and Mourikis, P. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
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Nature Communications 12 (1): 1269. 24 February 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg, L. and Paolantoni, C. and Longhi, S. and Mulorz, M.M. and Lence, T. and Wessels, H.H. and Dassi, E. and Aiello, G. and Sutandy, F.X.R. and Scheibe, M. and Edupuganti, R.R. and Busch, A. and Möckel, M.M. and Vermeulen, M. and Butter, F. and König, J. and Notarangelo, M. and Ohler, U. and Dieterich, C. and Quattrone, A. and Soldano, A. and Roignant, J.Y.
EMBO Journal 40 (4): e104975. 15 February 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.
Goetzke, C.C. and Althof, N. and Neumaier, H.L. and Heuser, A. and Kaya, Z. and Kespohl, M. and Klingel, K. and Beling, A.
Basic Research in Cardiology 116 (1): 7. 1 February 2021

Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C. and Karaiskos, N. and Boltengagen, A. and Walentin, K. and Redo, K. and Himmerkus, N. and Bleich, M. and Potter, S.S. and Potter, A.S. and Eckardt, K.U. and Kocks, C. and Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32 (2): 291-306. February 2021

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J. and Michaelis, E. and Greuel, S. and Heynol, V. and Lehmann, A. and Radbruch, H. and Meinhardt, J. and Miller, F. and Herbst, H. and Corman, V.M. and Westermann, J. and Bullinger, L. and Horst, D. and von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103 : 628-635. February 2021

Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation.
Kubo, N. and Ishii, H. and Xiong, X. and Bianco, S. and Meitinger, F. and Hu, R. and Hocker, J.D. and Conte, M. and Gorkin, D. and Yu, M. and Li, B. and Dixon, J.R. and Hu, M. and Nicodemi, M. and Zhao, H. and Ren, B.
Nature Structural & Molecular Biology 28 (2): 152-161. February 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L. and Kny, M. and Hahn, A. and Schmidt, S. and Wundersitz, S. and Todiras, M. and Lahmann, I. and Bandyopadhyay, A. and Wollersheim, T. and Kaderali, L. and Luft, F.C. and Birchmeier, C. and Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J. and Veviurko, G. and Bennett, N.C. and Hart, D.W. and Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

Uncovering de novo gene birth in yeast using deep transcriptomics.
Blevins, W.R. and Ruiz-Orera, J. and Messeguer, X. and Blasco-Moreno, B. and Villanueva-Cañas, J.L. and Espinar, L. and Díez, J. and Carey, L.B. and Albà, M.M.
Nature Communications 12 (1): 604. 27 January 2021

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Norin, U. and Rintisch, C. and Meng, L. and Forster, F. and Ekman, D. and Tuncel, J. and Klocke, K. and Bäcklund, J. and Yang, M. and Bonner, M.Y and Lahore, G.F. and James, J. and Shchetynsky, K. and Bergquist, M. and Gjertsson, I. and Hubner, N. and Bäckdahl, L. and Holmdahl, R.
Nature Communications 12 (1): 610. 27 January 2021

On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
Schreiber, C. and Amiri, B. and Heyn, J.C.J. and Rädler, J.O. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 118 (4): e2009959118. 26 January 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Harnett, D. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Günnigmann, M. and Zinnall, U. and Vieira-Vieira, C.H. and Schaub, T. and Münster-Wandowski, A. and Bürger, J. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Ohler, U. and Beule, D. and Mielke, T. and Tarabykin, V. and Landthaler, M. and Kramer, G. and Vida, I. and Selbach, M. and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

Arterialization requires the timely suppression of cell growth.
Luo, W. and Garcia-Gonzalez, I. and Fernández-Chacón, M. and Casquero-Garcia, V. and Sanchez-Muñoz, M.S. and Mühleder, S. and Garcia-Ortega, L. and Andrade, J. and Potente, M. and Benedito, R.
Nature 589 (7842): 437-441. 21 January 2021

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum.
Kuijpers, M. and Kochlamazashvili, G. and Stumpf, A. and Puchkov, D. and Swaminathan, A. and Lucht, M.T. and Krause, E. and Maritzen, T. and Schmitz, D. and Haucke, V.
Neuron 109 (2): 299-313. 20 January 2021

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Alcalá-Vida, R. and Seguin, J. and Lotz, C. and Molitor, A.M. and Irastorza-Azcarate, I. and Awada, A. and Karasu, N. and Bombardier, A. and Cosquer, B. and Skarmeta, J.L.G. and Cassel, J.C. and Boutillier, A.L. and Sexton, T. and Merienne, K.
Nature Communications 12 (1): 364. 13 January 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Rodríguez de los Santos, M. and Rivalan, M. and David, F.S. and Stumpf, A. and Pitsch, J. and Tsortouktzidis, D. and Velasquez, L.M. and Voigt, A. and Schilling, K. and Mattei, D. and Long, M. and Vogt, G. and Knaus, A. and Fischer-Zirnsak, B. and Wittler, L. and Timmermann, B. and Robinson, P.N. and Horn, D. and Mundlos, S. and Kornak, U. and Becker, A.J. and Schmitz, D. and Winter, Y. and Krawitz, P.M.
Proceedings of the National Academy of Sciences of the United States of America 118 (2): e2014481118. 12 January 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.
Gurumayum, S. and Jiang, P. and Hao, X. and Campos, T.L. and Young, N.D. and Korhonen, P.K. and Gasser, R.B. and Bork, P. and Zhao, X.M. and He, L.J. and Chen, W.H.
Nucleic Acids Research 49 (D1): D998-D1003. 8 January 2021

SMART: recent updates, new developments and status in 2020.
Letunic, I. and Khedkar, S. and Bork, P.
Nucleic Acids Research 49 (D1): D458-D460. 8 January 2021

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.
Szklarczyk, D. and Gable, A.L. and Nastou, K.C. and Lyon, D. and Kirsch, R. and Pyysalo, S. and Doncheva, N.T. and Legeay, M. and Fang, T. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 49 (D): D605-D612. 8 January 2021

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Prinz, C. and Starke, L. and Millward, J.M. and Fillmer, A. and Delgado, P.R. and Waiczies, H. and Pohlmann, A. and Rothe, M. and Nazaré, M. and Paul, F. and Niendorf, T. and Waiczies, S.
Theranostics 11 (6): 2490-2504. 1 January 2021

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A. and Haage, V. and Yang, S. and Wegner, S. and Ersoy, B. and Ugursu, B. and Rex, A. and Kronenberg, G. and Gertz, K. and Endres, M. and Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91 : 89-104. January 2021

Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection.
Melo, E.M. and Del Sarto, J. and Vago, J.P. and Tavares, L.P. and Rago, F. and Gonçalves, A.P.F. and Machado, M.G. and Aranda-Pardos, I. and Valiate, B.V.S. and Cassali, G.D. and Pinho, V. and Sousa, L.P. and A-Gonzalez, N. and Campagnole-Santos, M.J. and Bader, M. and Santos, R.A.S. and Machado, A.V. and Ludwig, S. and Teixeira, M.M.
Pharmacological Research 163 : 105292. January 2021

USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Schwaller, F. and Bégay, V. and García-García, G. and Taberner, F.J. and Moshourab, R. and McDonald, B. and Docter, T. and Kühnemund, J. and Ojeda-Alonso, J. and Paricio-Montesinos, R. and Lechner, S.G. and Poulet, J.F.A. and Millan, J.M. and Lewin, G.R.
Nature Neuroscience 24 (1): 74-81. January 2021

Early response to first-line anti-PD-1 treatment in Hodgkin lymphoma: a PET-based analysis from the prospective, randomized phase II NIVAHL trial.
Voltin, C.A. and Mettler, J. and van Heek, L. and Goergen, H. and Müller, H. and Baues, C. and Keller, U. and Meissner, J. and Trautmann-Grill, K. and Kerkhoff, A. and Fuchs, M. and Sasse, S. and von Tresckow, B. and Dietlein, M. and Borchmann, P. and Engert, A. and Kobe, C. and Bröckelmann, P.J.
Clinical Cancer Research 27 (2): 402-407. January 2021

Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
Wulf, G.G. and Altmann, B. and Ziepert, M. and D'Amore, F. and Held, G. and Greil, R. and Tournilhac, O. and Relander, T. and Viardot, A. and Wilhelm, M. and Wilhelm, C. and Pezzutto, A. and Zijlstra, J.M. and Van Den Neste, E. and Lugtenburg, P.J. and Doorduijn, J.K. and van Gelder, M. and van Imhoff, G.W. and Zettl, F. and Braulke, F. and Nickelsen, M. and Glass, B. and Rosenwald, A. and Gaulard, P. and Loeffler, M. and Pfreundschuh, M. and Schmitz, N. and Trümper, L.
Leukemia 35 (1): 143-155. January 2021

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
Kapp-Schwoerer, S. and Weber, D. and Corbacioglu, A. and Gaidzik, V.I. and Paschka, P. and Krönke, J. and Theis, F. and Rücker, F.G. and Teleanu, M.V. and Panina, E. and Jahn, N. and Herzig, J. and Kubanek, L. and Schrade, A. and Göhring, G. and Fiedler, W. and Kindler, T and Schroeder, T. and Mayer, K.T. and Lübbert, M. and Wattad, M. and Götze, K.S. and Horst, H.A. and Koller, E. and Wulf, G. and Schleicher, J. and Bentz, M. and Krauter, J. and Bullinger, L. and Krzykalla, J. and Benner, A. and Schlenk, R.F. and Thol, F. and Heuser, M. and Ganser, A. and Döhner, H and Döhner, K.
Blood 136 (26): 3041-3050. 24 December 2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J. and Heuberger, J. and Vidal, R. and Goveas, N. and Kosel, F. and Berenguer-Llergo, A. and Kranz, A. and Wulf-Goldenberg, A. and Behrens, D. and Melcher, B. and Sauer, S. and Vieth, M. and Batlle, E. and Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Cells of the adult human heart.
Litviňuková, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Worth, C.L. and Lindberg, E.L. and Kanda, M. and Polanski, K. and Heinig, M. and Lee, M.l and Nadelmann, E.R. and Roberts, K. and Tuck, L. and Fasouli, E.S. and DeLaughter, D.M. and McDonough, B. and Wakimoto, H. and Gorham, J.M. and Samari, S. and Mahbubani, K.T. and Saeb-Parsy, K. and Patone, G. and Boyle, J.J. and Zhang, H. and Zhang, H. and Viveiros, A. and Oudit, G.Y. and Bayraktar, O. and Seidman, J.G. and Seidman, C.E. and Noseda, M. and Hubner, N. and Teichmann, S.A.
Nature 588 (7838): 466-472. 17 December 2020

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S. and Bröckelmann, P.J. and Iaccarino, I. and Garcia-Marquez, M. and Borchmann, S. and Jochims, F. and Kotrova, M. and Pal, K. and Brüggemann, M. and Hartmann, E. and Sasse, S. and Kobe, C. and Mathas, S. and Soekler, M. and Keller, U. and Bormann, M. and Zimmermann, A. and Richter, J. and Fuchs, M. and von Tresckow, B. and Borchmann, P. and Schlößer, H. and von Bergwelt-Baildon, M. and Rosenwald, A. and Engert, A. and Klapper, W.
Blood 136 (25): 2851-2863. 17 December 2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P. and Mishra, N. and Tran, F. and Bahmer, T. and Best, L. and Blase, J.I. and Bordoni, D. and Franzenburg, J. and Geisen, U. and Josephs-Spaulding, J. and Köhler, P. and Künstner, A. and Rosati, E. and Aschenbrenner, A.C. and Bacher, P. and Baran, N. and Boysen, T. and Brandt, B. and Bruse, N. and Dörr, J. and Dräger, A. and Elke, G. and Ellinghaus, D. and Fischer, J. and Forster, M. and Franke, A. and Franzenburg, S. and Frey, N. and Friedrichs, A. and Fuß, J. and Glück, A. and Hamm, J. and Hinrichsen, F. and Hoeppner, M.P. and Imm, S. and Junker, R. and Kaiser, S. and Kan, Y.H. and Knoll, R. and Lange, C. and Laue, G. and Lier, C. and Lindner, M. and Marinos, G. and Markewitz, R. and Nattermann, J. and Noth, R. and Pickkers, P. and Rabe, K.F. and Renz, A. and Röcken, C. and Rupp, J. and Schaffarzyk, A. and Scheffold, A. and Schulte-Schrepping, J. and Schunk, D. and Skowasch, D. and Ulas, T. and Wandinger, K.P. and Wittig, M. and Zimmermann, J. and Busch, H. and Hoyer, B.F. and Kaleta, C. and Heyckendorf, J. and Kox, M. and Rybniker, J. and Schreiber, S. and Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Lowenstein, E.D. and Schöwel, V. and Spuler, S. and Akalin, A. and Birchmeier, C.
Nature Communications 11 : 6375. 11 December 2020

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
Veenvliet, J.V. and Bolondi, A. and Kretzmer, H. and Haut, L. and Scholze-Wittler, M. and Schifferl, D. and Koch, F. and Guignard, L. and Kumar, A.S. and Pustet, M. and Heimann, S. and Buschow, R. and Wittler, L. and Timmermann, B. and Meissner, A. and Herrmann, B.G.
Science 370 (6522): eaba4937. 11 December 2020

Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.
Reddington, J.P. and Garfield, D.A. and Sigalova, O.M. and Karabacak Calviello, A. and Marco-Ferreres, R. and Girardot, C. and Viales, R.R. and Degner, J.F. and Ohler, U. and Furlong, E.E.M.
Developmental Cell 55 (5): 648-664. 7 December 2020

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K. and Schnöder, T.M. and Perner, F. and Herzog, C. and Meiler, A. and Krishnamoorthy, G. and Huber, N. and Mohr, J. and Edelmann-Stephan, B. and Austin, R. and Brandt, S. and Palandri, F. and Schröder, N. and Isermann, B. and Edlich, F. and Sinha, A.U. and Ungelenk, M. and Hübner, C.A. and Zeiser, R. and Rahmig, S. and Waskow, C. and Coldham, I. and Ernst, T. and Hochhaus, A. and Jilg, S. and Jost, P.J. and Mullally, A. and Bullinger, L. and Mertens, P.R. and Lane, S.W. and Mann, M. and Heidel, F.H.
Nature 588 (7836): 157-163. 3 December 2020

A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration.
Polovitskaya, M.M. and Barbini, C. and Martinelli, D. and Harms, F.L. and Cole, F.S. and Calligari, P. and Bocchinfuso, G. and Stella, L. and Ciolfi, A. and Niceta, M. and Rizza, T. and Shinawi, M. and Sisco, K. and Johannsen, J. and Denecke, J. and Carrozzo, R. and Wegner, D.J. and Kutsche, K. and Tartaglia, M. and Jentsch, T.J.
American Journal of Human Genetics 107 (6): 1062-1077. 3 December 2020

Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.
Le Poul, Y. and Xin, Y. and Ling, L. and Mühling, B. and Jaenichen, R. and Hörl, D. and Bunk, D. and Harz, H. and Leonhardt, H. and Wang, Y. and Osipova, E. and Museridze, M. and Dharmadhikari, D. and Murphy, E. and Rohs, R. and Preibisch, S. and Prud'homme, B. and Gompel, N.
Science Advances 6 (49): eabe2955. 2 December 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T. and Graf, R. and Wulf-Goldenberg, A. and Stecklum, M. and Strauß, G. and Kühn, R. and Kocks, C. and Rajewsky, K. and Chu, V.T.
Molecular Therapy 28 (12): 2621-2634. 2 December 2020

CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
Herhaus, P. and Lipkova, J. and Lammer, F. and Yakushev, I. and Vag, T. and Slotta-Huspenina, J. and Habringer, S. and Lapa, C. and Pukrop, T. and Hellwig, D. and Wiestler, B. and Buck, A.K. and Deckert, M. and Wester, H.J. and Bassermann, F. and Schwaiger, M. and Weber, W.A. and Menze, B. and Keller, U.
Journal of Nuclear Medicine 61 (12): 1765-1771. 1 December 2020

S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants.
Willers, M. and Ulas, T. and Völlger, L. and Vogl, T. and Heinemann, A.S. and Pirr, S. and Pagel, J. and Fehlhaber, B. and Halle, O. and Schöning, J. and Schreek, S. and Löber, U. and Essex, M. and Hombach, P. and Graspeuntner, S. and Basic, M. and Bleich, A. and Cloppenborg-Schmidt, K. and Künzel, S. and Jonigk, D. and Rupp, J. and Hansen, G. and Förster, R. and Baines, J.F. and Härtel, C. and Schultze, J.L. and Forslund, S.K. and Roth, J. and Viemann, D.
Gastroenterology 159 (6): 2130-2145. December 2020

Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy.
Krug, K. and Jaehnig, E.J. and Satpathy, S. and Blumenberg, L. and Karpova, A. and Anurag, M. and Miles, G. and Mertins, P. and Geffen, Y. and Tang, L.C. and Heiman, D.I. and Cao, S. and Maruvka, Y.E. and Lei, J.T. and Huang, C. and Kothadia, R.B. and Colaprico, A. and Birger, C. and Wang, J. and Dou, Y. and Wen, B. and Shi, Z. and Liao, Y. and Wiznerowicz, M. and Wyczalkowski, M.A. and Chen, X.S. and Kennedy, J.J. and Paulovich, A.G. and Thiagarajan, M. and Kinsinger, C.R. and Hiltke, T. and Boja, E.S. and Mesri, M. and Robles, A.I. and Rodriguez, H. and Westbrook, T.F. and Ding, L. and Getz, G. and Clauser, K.R. and Fenyö, D. and Ruggles, K.V. and Zhang, B. and Mani, D.R and Carr, S.A. and Ellis, M.J. and Gillette, M.A.
Cell 183 (5): 1436-1456. 25 November 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

LifeTime and improving European healthcare through cell-based interceptive medicine.
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Nature 587 (7834): 377-386. 19 November 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Molinaro, A. and Bel Lassen, P. and Henricsson, M. and Wu, H. and Adriouch, S. and Belda, E. and Chakaroun, R. and Nielsen, T. and Bergh, P.O. and Rouault, C. and André, S. and Marquet, F. and Andreelli, F. and Salem, J.E. and Assmann, K. and Bastard, J.P. and Forslund, S. and Le Chatelier, E. and Falony, G. and Pons, N. and Prifti, E. and Quinquis, B. and Roume, H. and Vieira-Silva, S. and Hansen, T.H. and Pedersen, H.K. and Lewinter, C. and Sønderskov, N.B. and Køber, L. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Galan, P. and Dumas, M.E. and Raes, J. and Oppert, J.M. and Letunic, I. and Nielsen, J. and Bork, P. and Ehrlich, S.D. and Stumvoll, M. and Pedersen, O. and Aron-Wisnewsky, J. and Clément, K. and Bäckhed, F.
Nature Communications 11 (1): 5881. 18 November 2020

Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations.
Pandey, S. and Gruenbaum, A. and Kanashova, T. and Mertins, P. and Cluzel, P. and Chevrier, N.
Cell Systems 11 (5): 495-508. 18 November 2020

Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir, A. and Möller, J. and Arimont, M. and Bobkov, V. and Perpiñá-Viciano, C. and Hoffmann, C. and Inoue, A. and Heukers, R. and de Graaf, C. and Smit, M.J. and Annibale, P. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 117 (46): 29144-29154. 17 November 2020

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C. and Ritterhoff, T. and Weber, A. and Janowska, M.K. and Mustroph, M. and Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202 (10): 1445-1457. 15 November 2020

A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Kreye, J. and Reincke, S.M. and Kornau, H.C. and Sánchez-Sendin, E. and Corman, V.M. and Liu, H. and Yuan, M. and Wu, N.C. and Zhu, X. and Lee, C.C.D. and Trimpert, J. and Höltje, M. and Dietert, K. and Stöffler, L. and von Wardenburg, N. and van Hoof, S. and Homeyer, M.A. and Hoffmann, J. and Abdelgawad, A. and Gruber, A.D. and Bertzbach, L.D. and Vladimirova, D. and Li, L.Y. and Barthel, P.C. and Skriner, K. and Hocke, A.C. and Hippenstiel, S. and Witzenrath, M. and Suttorp, N. and Kurth, F. and Franke, C. and Endres, M. and Schmitz, D. and Jeworowski, L.M. and Richter, A. and Schmidt, M.L. and Schwarz, T. and Müller, M.A. and Drosten, C. and Wendisch, D. and Sander, L.E. and Osterrieder, N. and Wilson, I.A. and Prüss, H.
Cell 183 (4): 1058-1069. 12 November 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K. and Lim, E.L. and Petkovic, M. and Elizalde, S. and Birkbak, N.J. and Wilson, G.A. and Moore, D.A. and Grönroos, E. and Rowan, A. and Dewhurst, S.M. and Demeulemeester, J. and Dentro, S.C. and Horswell, S. and Au, L. and Haase, K. and Escudero, M. and Rosenthal, R. and Bakir, M.A. and Xu, H. and Litchfield, K. and Lu, W.T. and Mourikis, T.P. and Dietzen, M. and Spain, L. and Cresswell, G.D. and Biswas, D. and Lamy, P. and Nordentoft, I. and Harbst, K. and Castro-Giner, F. and Yates, L.R. and Caramia, F. and Jaulin, F. and Vicier, C. and Tomlinson, I.P.M. and Brastianos, P.K. and Cho, R.J. and Bastian, B.C. and Dyrskjøt, L. and Jönsson, G.B. and Savas, P. and Loi, S. and Campbell, P.J. and Andre, F. and Luscombe, N.M. and Steeghs, N. and Tjan-Heijnen, V.C.G. and Szallasi, Z. and Turajlic, S. and Jamal-Hanjani, M. and Van Loo, P. and Bakhoum, S.F. and Schwarz, R.F. and McGranahan, N. and Swanton, C.
Nature 587 (7832): 126-132. 5 November 2020

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S. and Hopf, L.V.M. and Bock-Bierbaum, T. and Lally, C.C.M. and Spahn, C.M.T. and Daumke, O.
Nature Communications 11 (1): 5506. 2 November 2020

The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel, B. and Czimmerer, Z. and Halasz, L. and Boto, P. and Kolostyak, Z. and Poliska, S. and Berger, W.K. and Tzerpos, P. and Nagy, G. and Horvath, A. and Hajas, G. and Cseh, T. and Nagy, A. and Sauer, S. and Francois-Deleuze, J. and Szatmari, I. and Bacsi, A. and Nagy, L.
Genes & Development 34 (21-22): 1474-1492. 1 November 2020

The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D. and Formichetti, S. and Junker, J.P. and Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16 (11): e9946. 1 November 2020

Monogenic variants in dystonia: an exome-wide sequencing study.
Zech, M. and Jech, R. and Boesch, S. and Škorvánek, M. and Weber, S. and Wagner, M. and Zhao, C. and Jochim, A. and Necpál, J. and Dincer, Y. and Vill, K. and Distelmaier, F. and Stoklosa, M. and Krenn, M. and Grunwald, S. and Bock-Bierbaum, T. and Fečíková, A. and Havránková, P. and Roth, J. and Příhodová, I. and Adamovičová, M. and Ulmanová, O. and Bechyně, K. and Danhofer, P. and Veselý, B. and Haň, V. and Pavelekova, P. and Gdovinová, Z. and Mantel, T. and Meindl, T. and Sitzberger, A. and Schröder, S. and Blaschek, A. and Roser, T. and Bonfert, M.V. and Haberlandt, E. and Plecko, B. and Leineweber, B. and Berweck, S. and Herberhold, T. and Langguth, B. and Švantnerová, J. and Minár, M. and Ramos-Rivera, G.A. and Wojcik, M.H. and Pajusalu, S. and Õunap, K. and Schatz, U.A. and Pölsler, L. and Milenkovic, I. and Laccone, F. and Pilshofer, V. and Colombo, R. and Patzer, S. and Iuso, A. and Vera, J. and Troncoso, M. and Fang, F. and Prokisch, H. and Wilbert, F. and Eckenweiler, M. and Graf, E. and Westphal, D.S. and Riedhammer, K.M. and Brunet, T. and Alhaddad, B. and Berutti, R. and Strom, T.M. and Hecht, M. and Baumann, M. and Wolf, M. and Telegrafi, A. and Person, R.E. and Zamora, F.M. and Henderson, L.B. and Weise, D. and Musacchio, T. and Volkmann, J. and Szuto, A. and Becker, J. and Cremer, K. and Sycha, T. and Zimprich, F. and Kraus, V. and Makowski, C. and Gonzalez-Alegre, P. and Bardakjian, T.M. and Ozelius, L.J. and Vetro, A. and Guerrini, R. and Maier, E. and Borggraefe, I. and Kuster, A. and Wortmann, S.B. and Hackenberg, A. and Steinfeld, R. and Assmann, B. and Staufner, C. and Opladen, T. and Růžička, E. and Cohn, R.D. and Dyment, D. and Chung, W.K. and Engels, H. and Ceballos-Baumann, A. and Ploski, R. and Daumke, O. and Haslinger, B. and Mall, V. and Oexle, K. and Winkelmann, J.
Lancet Neurology 19 (11): 908-918. November 2020

Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y. and Gilboa, T. and van Kooten, X.F. and Kobelt, D. and Huttner, D. and Stein, U. and Meller, A.
ACS Nano 14 (10): 13964-13974. 27 October 2020

A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C. and Mueller, L. and Ruzittu, S. and Mah, N. and Willnow, D. and Darrigrand, J.F. and Wilson, H. and Khosravinia, D. and Mahmoud, A.A. and Risolino, M. and Selleri, L. and Spagnoli, F.M.
Developmental Cell 55 (2): 150-162. 26 October 2020

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A. and van Rijssel, J. and Ramms, A.S. and Wild, R. and Hammer, J. and Merkel, M. and Derenbach, L. and Préau, L. and Hinkel, R. and Suarez-Martinez, I. and Schulte-Merker, S. and Vidal, R. and Sauer, S. and Kivelä, R. and Alitalo, K. and Kupatt, C. and van Buul, J.D. and le Noble, F.
Nature Communications 11 (1): 5319. 21 October 2020

Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.
Leistner, D.M. and Kränkel, N. and Meteva, D. and Abdelwahed, Y.S. and Seppelt, C. and Stähli, B.E. and Rai, H. and Skurk, C. and Lauten, A. and Mochmann, H.C. and Fröhlich, G. and Rauch-Kröhnert, U. and Flores, E. and Riedel, M. and Sieronski, L. and Kia, S. and Strässler, E. and Haghikia, A. and Dirks, F. and Steiner, J. K. and Mueller, D.N. and Volk, H.D. and Klotsche, J. and Joner, M. and Libby, P. and Landmesser, U.
European Heart Journal 41 (37): 3549-3560. 20 October 2020

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Microscopy with undetected photons in the mid-infrared.
Kviatkovsky, I. and Chrzanowski, H.M. and Avery, E.G. and Bartolomaeus, H. and Ramelow, S.
Science Advances 6 (42): eabd0264. 14 October 2020

Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan, H. and Glažar, P. and Latini, C. and Heizler, K. and Haase, J. and Hett, R. and Anders, M. and Weichmann, F. and Bruckmann, A. and Van den Berg, D. and Hüttelmaier, S. and Rajewsky, N. and Hackl, C. and Meister, G.
Nucleic Acids Research 48 (18): 10368-10382. 9 October 2020

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M. and Haas, S.A. and Franchini, P. and Xiong, P. and Simakov, O. and Kuhl, H. and Schöpflin, R. and Heller, D. and Moeinzadeh, M.H. and Heinrich, V. and Krannich, T. and Bressin, A. and Hartmann, M.F. and Wudy, S.A. and Dechmann, D.K.N. and Hurtado, A. and Barrionuevo, F.J. and Schindler, M. and Harabula, I. and Osterwalder, M. and Hiller, M. and Wittler, L. and Visel, A. and Timmermann, B. and Meyer, A. and Vingron, M. and Jiménez, R. and Mundlos, S. and Lupiáñez, D.G.
Science 370 (6513): 208-214. 9 October 2020

R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48 (18): e105. 9 October 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G. and Custodio, J. and Kallas, T. and Agostini, F. and Wernersson, E. and Spanjaard, B. and Mota, A. and Kolbeinsdottir, S. and Gelali, E. and Crosetto, N. and Bienko, M.
Nature Biotechnology 38 (10): 1184-1193. October 2020

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Poh, J. and Ponsford, A.H. and Boyd, J. and Woodsmith, J. and Stelzl, U. and Wanker, E. and Harper, N. and MacEwan, D. and Sanderson, C.M.
Redox Biology 37 : 101686. October 2020

Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D. and Ameen, M. and Guo, H. and Abilez, O.J. and Tian, L. and Mumbach, M.R. and Diecke, S. and Qin, X. and Liu, Y. and Yang, H. and Ma, N. and Gaddam, S. and Cunningham, N.J. and Gu, M. and Neofytou, E. and Prado, M. and Hildebrandt, T.B. and Karakikes, I. and Chang, H.Y. and Wu, J.C.
Developmental Cell 54 (6): 694-709. 28 September 2020

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B. and Schmidt, M. and Weisbach, H. and Gruska, I. and Vetter, B. and Imami, K. and Ostermann, E. and Brune, W. and Selbach, M. and Hagemeier, C. and Wiebusch, L.
Nature Communications 11 (1): 4845. 24 September 2020

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S. and Klimmeck, D. and Falcone, M. and Demir, A. and Pouya, A. and Zeisberger, P. and Lutz, C. and Tinelli, M. and Bischel, O. and Bullinger, L. and Thiede, C. and Flörcken, A. and Westermann, J. and Ehninger, G. and Ho, A.D. and Müller-Tidow, C. and Gu, Z. and Herrmann, C. and Krijgsveld, J. and Trumpp, A. and Hansson, J.
Blood 136 (13): 1507-1519. 24 September 2020

SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N. and Taberner, F.J. and Rangel Rojas, D. and Moroni, M. and Omberbasic, D. and Njoo, C. and Andrieux, A. and Gupta, P. and Bali, K.K. and Herpel, E. and Faghihi, F. and Fleming, T. and Dejean, A. and Lechner, S.G. and Nawroth, P.P. and Lewin, G.R. and Kuner, R.
Neuron 107 (6): 1141-1159. 23 September 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H. and Meyerson, W.U. and Dursi, L.J. and Wang, L.B. and Dong, G. and Liang, W.W. and Weerasinghe, A. and Li, S. and Li, Y. and Kelso, S. and Saksena, G. and Ellrott, K. and Wendl, M.C. and Wheeler, D.A. and Getz, G. and Simpson, J.T. and Gerstein, M.B. and Ding, Li
Nature Communications 11 (1): 4748. 21 September 2020

Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B. and Alonso, G. and Georgana, I. and El-Jesr, M. and Martín, R. and Shair, K.H.Y. and Fischer, C. and Sauer, S. and Maluquer de Motes, C. and Alcamí, A.
Science Advances 6 (38): eabb4565. 18 September 2020

Optical mapping of cAMP signaling at the nanometer scale.
Bock, A. and Annibale, P. and Konrad, C. and Hannawacker, A. and Anton, S.E. and Maiellaro, I. and Zabel, U. and Sivaramakrishnan, S. and Falcke, M. and Lohse, M.J.
Cell 182 (6): 1519-1530. 17 September 2020

Oxidative metabolism drives immortalization of neural stem cells during tumorigenesis.
Bonnay, F. and Veloso, A. and Steinmann, V. and Köcher, T. and Abdusselamoglu, M.D. and Bajaj, S. and Rivelles, E. and Landskron, L. and Esterbauer, H. and Zinzen, R.P. and Knoblich, J.A.
Cell 182 (6): 1490-1507. 17 September 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling.
Zhang, J.Z. and Lu, T.W. and Stolerman, L.M. and Tenner, B. and Yang, J.R. and Zhang, J.F. and Falcke, M. and Rangamani, P. and Taylor, S.S. and Mehta, S. and Zhang, J.
Cell 182 (6): 1531-1544. 17 September 2020

Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U. and Kleinsorge, M. and Roos, L. and Yigit, G. and Li, Y. and Barbarics, B. and El-Battrawy, I. and Lan, H. and Tiburcy, M. and Hindmarsh, R. and Lenz, C. and Salinas, G. and Diecke, S. and Müller, C. and Adham, I. and Altmüller, J. and Nürnberg, P. and Paul, T. and Zimmermann, W.H. and Hasenfuss, G. and Wollnik, B. and Cyganek, L.
Circulation 142 (11): 1059-1076. 15 September 2020

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf, R.Z. and Saez, B. and Sharda, A. and van Gastel, N. and Yu, V.W.C. and Baryawno, N. and Scadden, E.W. and Acharya, S. and Chattophadhyay, S. and Huang, C. and Viswanathan, V. and S'aulis, D. and Cobert, J. and Sykes, D.B. and Keibler, M.A. and Das, S. and Hutchinson, J.N. and Churchill, M. and Mukherjee, S. and Lee, D. and Mercier, F. and Doench, J. and Bullinger, L. and Logan, D.J. and Schreiber, S. and Stephanopoulos, G. and Rizzo, W.B. and Scadden, D.T.
Blood 136 (11): 1303-1316. 10 September 2020

Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W. and Shang, F. and Wang, X. and Fanti, A.K. and Greco, A. and Busch, K. and Klapproth, K. and Zhang, Q. and Quedenau, C. and Sauer, S. and Feyerabend, T.B. and Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27 (3): 383-395. 3 September 2020

Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C. and Buracchi, C. and Arcangeli, S. and Galimberti, S. and Valsecchi, M.G. and Perriello, V.M. and Rasko, T. and Alberti, G. and Magnani, C.F. and Cappuzzello, C. and Lundberg, F. and Pande, A. and Dastoli, G. and Introna, M. and Serafini, M. and Biagi, E. and Izsvák, Z. and Biondi, A. and Tettamanti, S.
Molecular Therapy 28 (9): 1974-1986. 2 September 2020

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A. and Carlo-Spiewok, A.S. and Malik, A.R. and Rothe, M. and Schipke, C.G. and Peters, O. and Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 16 (9): 1248-1258. September 2020

Blood pressure and angiogenic markers in pregnancy: contributors to pregnancy-induced hypertension and offspring cardiovascular risk.
Birukov, A.. and Herse, F. and Nielsen, J.H. and Kyhl, H.B. and Golic, M. and Kräker, K. and Haase, N. and Busjahn, A. and Bruun, S. and Jensen, B.L. and Müller, D.N. and Jensen, T.K. and Christesen, H.T. and Andersen, M.S. and Jørgensen, J.S. and Dechend, R. and Andersen, L.B.
Hypertension 76 (3): 901-909. September 2020

Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. and Isbilir, A. and Sungkaworn, T. and Osberg, B. and Karathanasis, C. and Sunkara, V. and Grushevskyi, E.O. and Bock, A. and Annibale, P. and Heilemann, M. and Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16 (9): 946-954. September 2020

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M. and Alpaugh, M. and Sciacca, G. and Saint-Pierre, M. and Masnata, M. and Denis, H.L. and Lévesque, S.A. and Herrmann, F. and Bazenet, C. and Garneau, A.P. and Isenring, P. and Truant, R. and Oueslati, A. and Gould, P.V. and Ast, A. and Wanker, E.E. and Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 26 (9): 5441–5463. September 2020

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I. and Beaton, N. and Bruderer, R. and Knobloch, T. and Barbisan, C. and Chandat, L. and Sudau, A. and Siepe, I. and Rinner, O. and de Souza, N. and Picotti, P. and Reiter, L.
Nature Communications 11 (1): 4200. 21 August 2020

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
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Science 369 (6505): 842-846. 14 August 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L. and Klaus, A. and Maas, J. and Morin-Poulard, I. and Weijts, B. and Schulte-Merker, S. and Berezikov, E. and Junker, J.P. and Robin, C.
Blood 136 (7): 831-844. 13 August 2020

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
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Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L. and Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27 (8): 717-725. August 2020

High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Hehlmann, R. and Voskanyan, A. and Lauseker, M. and Pfirrmann, M. and Kalmanti, L. and Rinaldetti, S. and Kohlbrenner, K. and Haferlach, C. and Schlegelberger, B. and Fabarius, A. and Seifarth, W. and Spieß, B. and Wuchter, P. and Krause, S. and Kolb, H.J. and Neubauer, A. and Hossfeld, D.K. and Nerl, C. and Gratwohl, A. and Baerlocher, G.M. and Burchert, A. and Brümmendorf, T.H. and Hasford, J. and Hochhaus, A. and Saußele, S. and Baccarani, M.
Leukemia 34 (8): 2074-2086. August 2020

Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M. and Ferreira, D.G. and Batalha, V.L. and Marques-Morgado, I. and Coelho, J.E. and Pereira, P. and Gomes, R. and Pinto, A. and Carvalho, S. and Canas, P.M. and Cuvelier, L. and Buée-Scherrer, V. and Faivre, E. and Baqi, Y. and Müller, C.E. and Pimentel, J. and Schiffmann, S.N. and Buée, L. and Bader, M. and Outeiro, T.F. and Blum, D. and Cunha, R.A. and Marie, H. and Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25 (8): 1876-1900. August 2020

Norman M. Kaplan: January 2, 1931-April 5, 2020.
Townsend, R.R. and DiPette, D.J. and Luft, F.C. and Weinberger, M.H. and Ram, V.
Hypertension 76 (2): 291-293. August 2020

Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
Preussner, M. and Gao, Q. and Morrison, E. and Herdt, O. and Finkernagel, F. and Schumann, M. and Krause, E. and Freund, C. and Chen, W. and Heyd, F.
Genome Biology 21 (1): 186. 29 July 2020

Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H. and Franz, A. and Jung, M. and Weickmann, S. and Ralla, B. and Kilic, E. and Stephan, C. and Fendler, A. and Jung, K.
Theranostics 10 (20): 9268-9279. 23 July 2020

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K. and Kase, J. and Dörr, J.R. and Trescher, S. and Bhattacharya, A. and Yu, Y. and Wailes, E.M. and Fan, D.N.Y. and Lohneis, P. and Milanovic, M. and Lau, A. and Lenze, D. and Hummel, M. and Chapuy, B. and Leser, U. and Reimann, M. and Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M. and Markó, L. and Schächterle, C. and Tsvetkov, D. and Cui, Y. and Maghsodi, S. and Bartolomaeus, T.U.P. and Maass, P.G. and Zühlke, K. and Gregersen, N. and Hübner, N. and Hodge, R. and Mühl, A. and Pohl, B. and Molé-Illas, R. and Geelhaar, A. and Walter, S. and Napieczynska, H. and Schelenz, S. and Taube, M. and Heuser, A. and Anistan, Y.M. and Qadri, F. and Todiras, M. and Plehm, R. and Popova, E. and Langanki, R. and Eichhorst, J. and Lehmann, M. and Wiesner, B. and Russwurm, M. and Forslund, S.K. and Kamer, I. and Müller, D.N. and Gollasch, M. and Aydin, A. and Bähring, S. and Bader, M. and Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
Toboso-Navasa, A. and Gunawan, A. and Morlino, G. and Nakagawa, R. and Taddei, A. and Damry, D. and Patel, Y. and Chakravarty, P. and Janz, M. and Kassiotis, G. and Brink, R. and Eilers, M. and Calado, D.P.
Journal of Experimental Medicine 217 (7): e20191933. 6 July 2020

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
Conte, M. and Fiorillo, L. and Bianco, S. and Chiariello, A.M. and Esposito, A. and Nicodemi, M.
Nature Communications 11 (1): 3289. 3 July 2020

VarFish: comprehensive DNA variant analysis for diagnostics and research.
Holtgrewe, M. and Stolpe, O. and Nieminen, M. and Mundlos, S. and Knaus, A. and Kornak, U. and Seelow, D. and Segebrecht, L. and Spielmann, M. and Fischer-Zirnsak, B. and Boschann, F. and Scholl, U. and Ehmke, N. and Beule, D.
Nucleic Acids Research 48 (W1): W162-W169. 2 July 2020

Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J. and Marczenke, M. and Rudolph, I.M. and Nielsen, R. and Storm, T. and Ilsoe Christensen, E. and Diecke, S. and Emma, F. and Willnow, T.E.
Kidney International 98 (1): 159-167. July 2020

AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I. and Roux, P.F. and de Freitas, J.A.N.L.F. and Robinson, L. and Doré, G. and Sun, B. and Belenki, D. and Milanovic, M. and Herbig, U. and Schmitt, C.A. and Gil, J. and Bischof, O.
Nature Cell Biology 22 (7): 842-855. July 2020

Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas.
Ruzittu, S. and Willnow, D. and Spagnoli, F.M.
Cold Spring Harbor Perspectives in Biology 12 (7): a035626. July 2020

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A. and Rousselle, A. and Klocke, J. and Bachmann, S. and Popovic, S. and Bontscho, J. and Schmidt-Ott, K.M. and Siffrin, V. and Jerke, U. and Ashraf, M.I. and Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Dynamic conjugate F-SHARP microscopy.
Papadopoulos, I.N. and Jouhanneau, J.S. and Takahashi, N. and Kaplan, D. and Larkum, M. and Poulet, J. and Judkewitz, B.
Light: Science & Applications 9 (1): 110. 30 June 2020

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T. and Yasuda, T. and Ronen, J. and Wirtz, T. and Weber, T. and Sack, U. and Caeser, R. and Zhang, J. and Li, X. and Chu, V.T. and Jauch, A. and Unger, K. and Hodson, D.J. and Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117 (25): 14421-14432. 23 June 2020

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F. and Fink, C. and Hüttemeister, J. and Kirchner, M. and Radke, M.H. and Lopez Carballo, J. and Wagner, E. and Kohl, T. and Lehnart, S.E. and Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M. and Fischer, A. and Goetzke, C.C. and Neumaier, H.L. and Sauter, M. and Kespohl, M. and Müller, A.M. and Meckes, C. and Salbach, C. and Schenk, M. and Heuser, A. and Landmesser, U. and Weiner, J. and Meder, B. and Lehmann, L. and Kratzer, A. and Klingel, K. and Katus, H.A. and Kaya, Z. and Beling, A.
Circulation 141 (23): 1885-1902. 9 June 2020

The sensory coding of warm perception.
Paricio-Montesinos, R. and Schwaller, F. and Udhayachandran, A. and Rau, F. and Walcher, J. and Evangelista, R. and Vriens, J. and Voets, T. and Poulet, J.F.A. and Lewin, G.R.
Neuron 106 (5): 830-841. 3 June 2020

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N. and Foster, D.J. and Cunningham, M.W. and Bercher, J. and Nguyen, T. and Shulga-Morskaya, S. and Milstein, S. and Shaikh, S. and Rollins, J. and Golic, M. and Herse, F. and Kräker, K. and Bendix, I. and Serdar, M. and Napieczynska, H. and Heuser, A. and Gellhaus, A. and Thiele, K. and Wallukat, G. and Müller, D.N. and LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130 (6): 2928-2942. 1 June 2020

Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J. and Goergen, H. and Keller, U. and Meissner, J. and Ordemann, R. and Halbsguth, T.V. and Sasse, S. and Sökler, M. and Kerkhoff, A. and Mathas, S. and Hüttmann, A. and Bormann, M. and Zimmermann, A. and Mettler, J. and Fuchs, M. and von Tresckow, B. and Baues, C. and Rosenwald, A. and Klapper, W. and Kobe, C. and Borchmann, P. and Engert, A.
JAMA Oncology 6 (6): 872-880. June 2020

A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
Kaminski, M.M. and Alcantar, M.A. and Lape, I.T. and Greensmith, R. and Huske, A.C. and Valeri, J.A. and Marty, F.M. and Klämbt, V. and Azzi, J. and Akalin, E. and Riella, L.V. and Collins, J.J.
Nature Biomedical Engineering 4 (6): 601-609. June 2020

Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes.
Lekva, T. and Sugulle, M. and Moe, K. and Redman, C. and Dechend, R. and Staff, A.C.
Hypertension 75 (6): 1513-1522. June 2020

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E. and Lafzi, A. and Moutinho, C. and Ziegenhain, C. and McCarthy, D.J. and Álvarez-Varela, A. and Batlle, E. and Sagar, and Grün, D. and Lau, J.K. and Boutet, S.C. and Sanada, C. and Ooi, A. and Jones, R.C. and Kaihara, K. and Brampton, C. and Talaga, Y. and Sasagawa, Y. and Tanaka, K. and Hayashi, T. and Braeuning, C. and Fischer, C. and Sauer, S. and Trefzer, T. and Conrad, C. and Adiconis, X. and Nguyen, L.T. and Regev, A. and Levin, J.Z. and Parekh, S. and Janjic, A. and Wange, L.E. and Bagnoli, J.W. and Enard, W. and Gut, M. and Sandberg, R. and Nikaido, I. and Gut, I. and Stegle, O. and Heyn, H.
Nature Biotechnology 38 (6): 747-755. June 2020

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Uroda, T. and Chillón, I. and Annibale, P. and Teulon, J.M. and Pessey, O. and Karuppasamy, M. and Pellequer, J.L. and Marcia, M.
Nature Protocols 15 (6): 2107-2139. June 2020

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Vieira-Silva, S. and Falony, G. and Belda, E. and Nielsen, T. and Aron-Wisnewsky, J. and Chakaroun, R. and Forslund, S.K. and Assmann, K. and Valles-Colomer, M. and Nguyen, T..D. and Proost, S. and Prifti, E. and Tremaroli, V. and Pons, N. and Le Chatelier, E. and Andreelli, F. and Bastard, J.P. and Coelho, L.P. and Galleron, N. and Hansen, T.H. and Hulot, J.S. and Lewinter, C. and Pedersen, H.K. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Søndertoft, N.B. and Touch, S. and Dumas, M.E. and Ehrlich, S.D. and Galan, P. and Gøtze, J.P. and Hansen, T. and Holst, J.J. and Køber, L. and Letunic, I. and Nielsen, J. and Oppert, J.M. and Stumvoll, M. and Vestergaard, H. and Zucker, J.D. and Bork, P. and Pedersen, O. and Bäckhed, F. and Clément, K. and Raes, J.
Nature 581 (7808): 310-315. 21 May 2020

Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C. and Chen, X. and Planells-Cases, R. and Chu, J. and Wang, L. and Cao, L. and Li, Z. and López-Cayuqueo, K.I. and Xie, Y. and Ye, S. and Wang, X. and Ullrich, F. and Ma, S. and Fang, Y. and Zhang, X. and Qian, Z. and Liang, X. and Cai, S.Q. and Jiang, Z. and Zhou, D. and Leng, Q. and Xiao, T.S. and Lan, K. and Yang, Ji. and Li, H. and Peng, C. and Qiu, Z. and Jentsch, T.J. and Xiao, H.
Immunity 52 (5): 767-781. 19 May 2020

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S. and Gimber, N. and Deuschel, D. and Stuhlmann, T. and Puchkov, D. and Farsi, Z. and Ludwig, C.F. and Novarino, G. and López-Cayuqueo, K.I. and Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39 (9): e103358. 4 May 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. and Wagner, L.K. and Li, H. and Dörr, D. and Medaglia, C. and Paul, F. and Shemer, A. and Jung, S. and Yona, S. and Mack, M. and Leutz, A. and Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S. and Alanis-Lobato, G. and Pribyl, J. and Raskó, T. and Tichy, B. and Mikulasek, K. and Tsagiopoulou, M. and Oppelt, J. and Kastrinaki, G. and Lefaki, M. and Singh, M. and Zink, A. and Chondrogianni, N. and Psomopoulos, F. and Prigione, A. and Ivics, Z. and Pospisilova, S. and Skladal, P. and Izsvák, Z. and Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32 : 101458. May 2020

Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.
Maistrenko, O.M. and Mende, D.R. and Luetge, M. and Hildebrand, F. and Schmidt, T.S.B. and Li, S.S. and Rodrigues, J.F.M. and von Mering, C. and Pedro Coelho, L. and Huerta-Cepas, J. and Sunagawa, S. and Bork, P.
ISME Journal 14 (5): 1247-1259. May 2020

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Sungnak, W. and Huang, N. and Bécavin, C. and Berg, M. and Queen, R. and Litvinukova, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Sampaziotis, F. and Worlock, K.B. and Yoshida, M. and Barnes, J.L.
Nature Medicine 26 (5): 681-687. May 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A. and Kang, M.C. and Yang, W.M. and Hwang, W.M. and Kim, S.S. and Hong, S.H. and Heo, J.I. and Vijyakumar, A. and Pereira de Moura, L. and Uner, A. and Huang, H. and Lee, S.H. and Lima, I.S. and Park, K.S. and Kim, M.S. and Dagon, Y. and Willnow, T.E. and Aroda, V. and Ciaraldi, T.P. and Henry, R.R. and Kim, Y.B.
Nature Communications 11 (1): 2024. 24 April 2020

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N. and McKenzie, S. and Beed, P. and English, D.F. and Oldani, S. and Tukker, J.J. and Buzsáki, G. and Schmitz, D.
Nature Communications 11 (1): 1947. 23 April 2020

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M. and Ruiz-Orera, J. and Albà, M.M. and Eyras, E.
Nature Communications 11 (1): 1768. 14 April 2020

B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L. and Park, J.K. and Henke, N. and Rong, S. and Balogh, A. and Klamer, S. and Bartolomaeus, H. and Wilck, N. and Ruland, J. and Forslund, S.K. and Luft, F.C. and Dechend, R. and Müller, D.N.
Cardiovascular Research 116 (5): 1059-1070. 1 April 2020

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha, S. and Baurecht, H. and Novak, N. and Rodríguez, E. and Bej, S. and Mayr, G. and Emmert, H. and Stölzl, D. and Gerdes, S. and Degenhardt, F. and Hübenthal, M. and Ellinghaus, E. and Jung, E.S. and Kässens, J.C. and Wienbrandt, L. and Lieb, W. and Müller-Nurasyid, M. and Hotze, M. and Dand, N. and Grosche, S. and Marenholz, I. and Arnold, A. and Homuth, G. and Schmidt, C.O. and Wehkamp, U. and Nöthen, M.M. and Hoffmann, P. and Paternoster, L. and Standl, M. and Bønnelykke, K. and Ahluwalia, T.S. and Bisgaard, H. and Peters, A. and Gieger, C. and Waldenberger, M. and Schulz, H. and Strauch, K. and Werfel, T. and Lee, Y.A. and Wolfien, M. and Rosenstiel, P. and Wolkenhauer, O. and Schreiber, St. and Franke, A. and Weidinger, S. and Ellinghaus, D.
Journal of Allergy and Clinical Immunology 145 (4): 1208-1218. April 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G. and Roeschert, I. and Prinz, F. and Baluapuri, A. and Silveira Vidal, R. and Schülein-Völk, C. and Chang, Y.C. and Ade, C.P. and Mastrobuoni, G. and Girard, C. and Kumar, A. and Wortmann, L. and Walz, S. and Lührmann, R. and Kempa, S. and Kuster, B. and Wolf, E. and Mumberg, D. and Eilers, M.
Molecular Cell 77 (6): 1322-1339. 19 March 2020

Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A. and Gisevius, B. and Hirschberg, S. and Yissachar, N. and Stangl, G.I. and Eilers, E. and Bader, V. and Haase, S. and Kaisler, J. and David, C. and Schneider, R. and Troisi, R. and Zent, D. and Hegelmaier, T. and Dokalis, N. and Gerstein, S. and Del Mare-Roumani, S. and Amidror, S. and Staszewski, O. and Poschmann, G. and Stühler, K. and Hirche, F. and Balogh, A. and Kempa, S. and Träger, P. and Zaiss, M.M. and Holm, J.B. and Massa, M.G. and Nielsen, H.B. and Faissner, A. and Lukas, C. and Gatermann, S.G. and Scholz, M. and Przuntek, H. and Prinz, M. and Forslund, S.K. and Winklhofer, K.F. and Müller, D.N. and Linker, R.A. and Gold, R. and Haghikia, A.
Cell 180 (6): 1067-1080. 19 March 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C. and Müller, M. and Pak, H.S. and Harnett, D. and Huber, F. and Grun, D. and Leleu, M. and Auger, A. and Arnaud, M. and Stevenson, B.J. and Michaux, J. and Bilic, I. and Hirsekorn, A. and Calviello, L. and Simó-Riudalbas, L. and Planet, E. and Lubiński, J. and Bryśkiewicz, M. and Wiznerowicz, M. and Xenarios, I. and Zhang, L. and Trono, D. and Harari, A. and Ohler, U. and Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11 (1): 1293. 10 March 2020

CRISPLD1: a novel conserved target in the transition to human heart failure.
Khadjeh, S. and Hindmarsh, V. and Weber, F. and Cyganek, L. and Vidal, R.O. and Torkieh, S. and Streckfuss-Bömeke, K. and Lbik, D. and Tiburcy, M. and Mohamed, B.A. and Bonn, S. and Toischer, K. and Hasenfuss, G.
Basic Research in Cardiology 115 (3): 27. 7 March 2020

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K. and Jung, M. and Foinquinos, A. and San José, G. and Beaumont, J. and Bock, K. and Grote-Levi, L. and Xiao, K. and Bär, C. and Pfanne, A. and Just, A. and Zimmer, K. and Ngoy, S. and López, B. and Ravassa, S. and Samolovac, S. and Janssen-Peters, H. and Remke, J. and Scherf, K. and Dangwal, S. and Piccoli, M.T. and Kleemiss, F. and Kreutzer, F.P. and Kenneweg, F. and Leonardy, J. and Hobuß, L. and Santer, L. and Do, Q.T. and Geffers, R. and Braesen, J.H. and Schmitz, J. and Brandenberger, C. and Müller, D.N. and Wilck, N. and Kaever, V. and Bähre, H. and Batkai, S. and Fiedler, J. and Alexander, K.M. and Wertheim, B.M. and Fisch, S. and Liao, R. and Diez, J. and González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort.
Aglago, E.K. and Huybrechts, I. and Murphy, N. and Casagrande, C. and Nicolas, G. and Pischon, T. and Fedirko, V. and Severi, G. and Boutron-Ruault, M.C. and Fournier, A. and Katzke, V. and Kühn, T. and Olsen, A. and Tjønneland, A. and Dahm, C.C. and Overvad, K. and Lasheras, C. and Agudo, A. and Sánchez, M.J. and Amiano, P. and Huerta, J.M. and Ardanaz, E. and Perez-Cornago, A. and Trichopoulou, A. and Karakatsani, A. and Martimianaki, G. and Palli, D. and Pala, V. and Tumino, R. and Naccarati, A. and Panico, S. and Bueno-de-Mesquita, B. and May, A. and Derksen, J.W.G. and Hellstrand, S. and Ohlsson, B. and Wennberg, M. and Van Guelpen, B. and Skeie, G. and Brustad, M. and Weiderpass, E. and Cross, A.J. and Ward, H. and Riboli, E. and Norat, T. and Chajes, V. and Gunter, M.J.
Clinical Gastroenterology and Hepatology 18 (3): 654-666. March 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M. and Menzel, L. and Grau, M. and Vion, A.C. and Anagnostopoulos, I. and Zapukhlyak, M. and Gerlach, K. and Kammertöns, T. and Hehlgans, T. and Zschummel, M. and Lenz, G. and Gerhardt, H. and Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability.
Kornau, H.C. and Kreye, J. and Stumpf, A. and Fukata, Y. and Parthier, D. and Sammons, R.P. and Imbrosci, B. and Kurpjuweit, S. and Kowski, A.B. and Fukata, M. and Prüss, H. and Schmitz, D.
Annals of Neurology 87 (3): 405-418. March 2020

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S. and Lim, E.L. and Horswell, S. and Haase, K. and Huebner, A. and Dietzen, M. and Mourikis, T.P. and Watkins, T.B.K. and Rowan, A. and Dewhurst, S.M. and Birkbak, N.J. and Wilson, G.A. and Van Loo, P. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature Genetics 52 (3): 283-293. March 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

Pan-cancer analysis of whole genomes.

Nature 578 (7793): 82-93. 6 February 2020

Genomic basis for RNA alterations in cancer.
Calabrese, C. and Davidson, N.R. and Demircioğlu, D. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, Q. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Huska, M.R. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
Nature 578 (7793): 129-136. 6 February 2020

Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M. and Fischer, C. and Urzi, A. and Vidal, R. and Kunz, S. and Ruffault, P.L. and Kabuss, L. and Hube, I. and Gazzerro, E. and Birchmeier, C. and Spuler, S. and Sauer, S. and Gouti, M.
Cell Stem Cell 26 (2): 172-186. 6 February 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y. and Chen, F. and Fonseca, N.A. and He, Y. and Fujita, M. and Nakagawa, H. and Zhang, Z. and Brazma, A. and Creighton, C.J.
Nature Communications 11 (1): 736. 5 February 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A. and Kny, M. and Pablo-Tortola, C. and Todiras, M. and Willenbrock, M. and Schmidt, S. and Schmoeckel, K. and Jorde, I. and Nowak, M. and Jarosch, E. and Sommer, T. and Bröker, B.M. and Felix, S.B. and Scheidereit, C. and Weber-Carstens, S. and Butter, C. and Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel, J. and Hansen, C.E. and Bettoni, C. and Vogt, M.A. and Lembrich, B. and Natsagdorj, R. and Huber, G. and Brands, J. and Schmidt, K. and Assmann, J.C. and Stölting, I. and Saar, K. and Sedlacik, J. and Fiehler, J. and Ludewig, P. and Wegmann, M. and Feller, N. and Richter, M. and Müller-Fielitz, H. and Walther, T. and König, G.M. and Kostenis, E. and Raasch, W. and Hübner, N. and Gass, P. and Offermanns, S. and de Wit, C. and Wagner, C.A. and Schwaninger, M.
Proceedings of the National Academy of Sciences of the United States of America 117 (3): 1753-1761. 21 January 2020

Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D. and Mani, D.C. and Satpathy, S. and Fereshetian, S. and Gasser, J.A. and Svinkina, T. and Olive, M.E. and Ebert, B.L. and Mertins, P. and Carr, S.A.
Nature Communications 11 (1): 359. 17 January 2020

A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
Galupa, R. and Nora, E.P. and Worsley-Hunt, R. and Picard, C. and Gard, C. and van Bemmel, J.G. and Servant, N. and Zhan, Y. and El Marjou, F. and Johanneau, C. and Diabangouaya, P. and Le Saux, A. and Lameiras, S. and Pipoli da Fonseca, J. and Loos, F. and Gribnau, J. and Baulande, S. and Ohler, U. and Giorgetti, L. and Heard, E.
Molecular Cell 77 (2): 352-367. 16 January 2020

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J. and Mahnke, N.A. and Hofman, Z.L.M. and Maat, S.d. and Wu, J. and Bonnekoh, H. and Pengelly, R.J. and Ennis, S. and Holloway, J.W. and Kirchner, M. and Mertins, P. and Church, M.K. and Maurer, M. and Maas, C. and Krause, K.
Nature Communications 11 (1): 179. 10 January 2020

proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Mende, D.R. and Letunic, I. and Maistrenko, O.M. and Schmidt, T.S.B. and Milanese, A. and Paoli, L. and Hernández-Plaza, A. and Orakov, A.N. and Forslund, S.K. and Sunagawa, S. and Zeller, G. and Huerta-Cepas, J. and Coelho, L.P. and Bork, P.
Nucleic Acids Research 48 (D1): D621-D625. 8 January 2020

A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L. and Miskey, C. and Zuliani, C. and Querques, I. and Kapitonov, V. and Laukó, A. and Fehér, A. and Palazzo, A. and Diem, T. and Lustig, J. and Sebe, A. and Wang, Y. and Dinnyés, A. and Izsvák, Z. and Barabas, O. and Ivics, Z.
Nucleic Acids Research 48 (1): 316-331. 1 January 2020

Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Dusek, P. and Mekle, R. and Skowronska, M. and Acosta-Cabronero, J. and Huelnhagen, T. and Robinson, S.D. and Schubert, F. and Deschauer, M. and Els, A. and Ittermann, B. and Schottmann, G. and Madai, V.I. and Paul, F. and Klopstock, T. and Kmiec, T. and Niendorf, T. and Wuerfel, J. and Schneider, S.A.
Movement Disorders 35 (1): 142-150. January 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

Statins reverse postpartum cardiovascular dysfunction in a rat model of preeclampsia.
Kräker, K. and O'Driscoll, J.M. and Schütte, T. and Herse, F. and Patey, O. and Golic, M. and Geisberger, S. and Verlohren, S. and Birukov, A. and Heuser, A. and Mueller, D.N. and Thilaganathan, B. and Dechend, R. and Haase, N.
Hypertension 75 (1): 202-210. January 2020

Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
Pivovarova-Ramich, O. and Markova, M. and Weber, D. and Sucher, S. and Hornemann, S. and Rudovich, N. and Raila, J. and Sunaga-Franze, D. and Sauer, S. and Rohn, S. and Pfeiffer, A.F.H. and Grune, T.
Redox Biology 29 (2): 101397. January 2020

Phosphorylation of RAB7 by TBK1/IKKε regulates innate immune signaling in triple negative breast cancer.
Ritter, J.L. and Zhu, Z. and Thai, T.C. and Mahadevan, N.R. and Mertins, P. and Knelson, E.H. and Piel, B.P. and Han, S. and Jaffe, J.D. and Carr, S.A. and Barbie, D.A. and Barbie, T.U.
Cancer Research 80 (1): 44-56. January 2020

Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent.
Serfozo, P. and Wysocki, J. and Gulua, G. and Schulze, A. and Ye, M. and Liu, P. and Jin, J. and Bader, M. and Myöhänen, T. and García-Horsman, J.A. and Batlle, D.
Hypertension 75 (1): 173-182. January 2020

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A. and Escobar Fernandez, H. and Karaiskos, N. and Grunwald, S.A. and Metzler, E. and Kieshauer, J. and Sauer, S. and Pasemann, D. and Malfatti, E. and Mompoint, D. and Quijano-Roy, S. and Boltengagen, A. and Schneider, J. and Schülke, M. and Kunz, S. and Carlier, R. and Birchmeier, C. and Amthor, H. and Spuler, A. and Kocks, C. and Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

Gene expression cartography.
Nitzan, M. and Karaiskos, N. and Friedman, N. and Rajewsky, N.
Nature 576 (7785): 132-137. 5 December 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Wang, X. and Eichelbaum, K. and Sadewasser, A. and Husic, I. and Paki, K. and Budt, M. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

Long-term effects of Na(+)/Ca(2+) exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Primessnig, U. and Bracic, T. and Levijoki, J. and Otsomaa, L. and Pollesello, P. and Falcke, M. and Pieske, B. and Heinzel, F.R.
European Journal of Heart Failure 21 (12): 1543-1552. December 2019

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Csaba, Z. and Verdonk, F. and Montané, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Baud, O. and Rowitch, D. and Miron, V. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
Brain 142 (12): 3806-3833. December 2019

Gene expression changes and community turnover differentially shape the global ocean metatranscriptome.
Salazar, G. and Paoli, L. and Alberti, A. and Huerta-Cepas, J. and Ruscheweyh, H.J. and Cuenca, M. and Field, C.M. and Coelho, L.P. and Cruaud, C. and Engelen, S. and Gregory, A.C. and Labadie, K. and Marec, C. and Pelletier, E. and Royo-Llonch, M. and Roux, S. and Sánchez, P. and Uehara, H. and Zayed, A.A. and Zeller, G. and Carmichael, M. and Dimier, C. and Ferland, J. and Kandels, S. and Picheral, M. and Pisarev, S. and Poulain, J. and Acinas, S.G. and Babin, M. and Bork, P. and Bowler, C. and de Vargas, C. and Guidi, L. and Hingamp, P. and Iudicone, D. and Karp-Boss, L. and Karsenti, E. and Ogata, H. and Pesant, S. and Speich, S. and Sullivan, M.B. and Wincker, P. and Sunagawa, S.
Cell 179 (5): 1068-1083. 14 November 2019

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Schewe, J. and Seidel, E. and Forslund, S. and Marko, L. and Peters, J. and Muller, D.N. and Fahlke, C. and Stölting, G. and Scholl, U.
Nature Communications 10 (1): 5155. 14 November 2019

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X. and You, X. and Langer, J.D. and Hou, J. and Rupprecht, F. and Vlatkovic, I. and Quedenau, C. and Tushev, G. and Epstein, I. and Schaefke, B. and Sun, W. and Fang, L. and Li, G. and Hu, Y. and Schuman, E.M. and Chen, W.
Nature Communications 10 (1): 5009. 1 November 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Bosse, J. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J. and Weithauser, A. and Witkowski, M. and Rauch, B.H. and Savvatis, K. and Dörner, A. and Tabaraie, T. and Kasner, M. and Moos, V. and Bösel, D. and Gotthardt, M. and Radke, M.H. and Wegner, M. and Bobbert, P. and Lassner, D. and Tschöpe, C. and Schutheiss, H.P. and Felix, S.B. and Landmesser, U. and Rauch, U.
European Heart Journal 40 (40): 3318-3332. 21 October 2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B. and Hewitt, S.L. and Heltemes-Harris, L.M. and Mandal, M. and Johnson, K. and Rajewsky, K. and Koralov, S.B. and Clark, M.R. and Farrar, M.A. and Skok, J.A.
Nature Communications 10 (1): 4768. 18 October 2019

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C. and Orozco, I.J. and Hoegg-Beiler, M.B. and Soria, A.H. and Hübner, C.A. and Fernandes-Rosa, F.L. and Boulkroun, S. and Zennaro, M.C. and Jentsch, T.J.
Nature Communications 10 (1): 4678. 15 October 2019

A clonal expression biomarker associates with lung cancer mortality.
Biswas, D. and Birkbak, N.J. and Rosenthal, R. and Hiley, C.T. and Lim, E.L. and Papp, K. and Boeing, S. and Krzystanek, M. and Djureinovic, D. and La Fleur, L. and Greco, M. and Döme, B. and Fillinger, J. and Brunnström, H. and Wu, Y. and Moore, D.A. and Skrzypski, M. and Abbosh, C. and Litchfield, K. and Al Bakir, M. and Watkins, T.B.K. and Veeriah, S. and Wilson, G.A. and Jamal-Hanjani, M. and Moldvay, J. and Botling, J. and Chinnaiyan, A.M. and Micke, P. and Hackshaw, A. and Bartek, J. and Csabai, I. and Szallasi, Z. and Herrero, J. and McGranahan, N. and Swanton, C.
Nature Medicine 25 (10): 1540-1548. October 2019

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
Chemi, F. and Rothwell, D.G. and McGranahan, N. and Gulati, S. and Abbosh, C. and Pearce, S.P. and Zhou, C. and Wilson, G.A. and Jamal-Hanjani, M. and Birkbak, N. and Pierce, J. and Kim, C.S. and Ferdous, S. and Burt, D.J. and Slane-Tan, D. and Gomes, F. and Moore, D. and Shah, R. and Al Bakir, M. and Hiley, C. and Veeriah, S. and Summers, Y. and Crosbie, P. and Ward, S. and Mesquita, B. and Dynowski, M. and Biswas, D. and Tugwood, J. and Blackhall, F. and Miller, C. and Hackshaw, A. and Brady, G. and Swanton, C. and Dive, C.
Nature Medicine 25 (10): 1534-1539. October 2019

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Joshi, K. and de Massy, M.R. and Ismail, M. and Reading, J.L. and Uddin, I. and Woolston, A. and Hatipoglu, E. and Oakes, T. and Rosenthal, R. and Peacock, T. and Ronel, T. and Noursadeghi, M. and Turati, V. and Furness, A.J.S. and Georgiou, A. and Wong, Y.N.S. and Ben Aissa, A. and Sunderland, M.W. and Jamal-Hanjani, M. and Veeriah, S. and Birkbak, N.J. and Wilson, G.A. and Hiley, C.T. and Ghorani, E. and Guerra-Assunção, J.A. and Herrero, J. and Enver, T. and Hadrup, S.R. and Hackshaw, A. and Peggs, K.S. and McGranahan, N. and Swanton, C. and Quezada, S.A. and Chain, B.
Nature Medicine 25 (10): 1549-1559. October 2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C. and Berger, H. and Antanaviciute, A. and Vidal, R. and Sauer, S. and Simmons, A. and Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T. and Zhou, X. and Kosla, J. and Adili, A. and Garcia Beccaria, M. and Kotsiliti, E. and Pfister, D. and Johlke, A.L. and Sinha, A. and Sankowski, R. and Schick, M. and Lewis, R. and Dokalis, N. and Seubert, B. and Höchst, B. and Inverso, D. and Heide, D. and Zhang, W. and Weihrich, P. and Manske, K. and Wohlleber, D. and Anton, M. and Hoellein, A. and Seleznik, G. and Bremer, J. and Bleul, S. and Augustin, H.G. and Scherer, F. and Koedel, U. and Weber, A. and Protzer, U. and Förster, R. and Wirth, T. and Aguzzi, A. and Meissner, F. and Prinz, M. and Baumann, B. and Höpken, U.E. and Knolle, P.A. and von Baumgarten, L. and Keller, U. and Heikenwalder, M.
Cancer Cell 36 (3): 250-267. 16 September 2019

Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K. and Imami, K. and Rajewsky, N.
Nature Communications 10 (1): 4205. 16 September 2019

Widespread translational control of fibrosis in the human heart by RNA-binding proteins.
Chothani, S. and Schäfer, S. and Adami, E. and Viswanathan, S. and Widjaja, A.A. and Langley, S.R. and Tan, J. and Wang, M. and Quaife, N.M. and Pua, C.J. and D'Agostino, G. and Shekeran, S.G. and George, B.L. and Lim, S. and Cao, E.Y. and van Heesch, S. and Witte, F. and Felkin, L.E. and Christodoulou, E.G. and Dong, J. and Blachut, S. and Patone, G. and Barton, P.J.R. and Hubner, N. and Cook, S.A. and Rackham, O.J.L.
Circulation 140 (11): 937-951. 10 September 2019

Antibiotics-induced monodominance of a novel gut bacterial order.
Hildebrand, F. and Moitinho-Silva, L. and Blasche, S. and Jahn, M.T.T. and Gossmann, T.I. and Heuerta Cepas, J. and Hercog, R. and Luetge, M. and Bahram, M. and Pryszlak, A. and Alves, R.J. and Waszak, S.M. and Zhu, A. and Ye, L. and Costea, P.I. and Aalvink, S. and Belzer, C. and Forslund, S.K. and Sunagawa, S. and Hentschel, U. and Merten, C. and Patil, K.R. and Benes, V. and Bork, P.
Gut 68 (10): 1781-1790. 9 September 2019

Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
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BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
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FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
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Maximizing binary interactome mapping with a minimal number of assays.
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Postnatal Tshz3 deletion drives altered corticostriatal function and autism spectrum disorder-like behavior.
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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
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Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
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Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
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Nature 571 (7765): 429-433. 18 July 2019

Genetics of intellectual disability in consanguineous families.
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R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
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The translational landscape of the human heart.
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HOT or not: examining the basis of high-occupancy target regions.
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Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
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Blood 133 (24): 2597-2609. 13 June 2019

Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
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Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints.
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NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language.
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Microbiome 7 (1): 84. 3 June 2019

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
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Nature Genetics 51 (6): 1011-1023. June 2019

Rapid molecular evolution of pain insensitivity in multiple African rodents.
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Science 364 (6443): 852-859. 31 May 2019

Disentangling genetic and environmental effects on the proteotypes of individuals.
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Cell 177 (5): 1308-1318. 16 May 2019

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities.
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Cell 177 (4): 1035-1049. 2 May 2019

Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
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Association between physical activity and risk of hepatobiliary cancers: a multinational cohort study.
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Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
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Nature Immunology 20 (5): 546-558. May 2019

FIP200 claw domain binding to p62 promotes autophagosome formation at ubiquitin condensates.
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Molecular Cell 74 (2): 330-346. 18 April 2019

SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes.
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Circulation Research 124 (8): 1172-1183. 12 April 2019

Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
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Circulation 139 (15): 1813-1827. 9 April 2019

Global identification of functional microRNA-mRNA interactions in Drosophila.
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Nature Communications 10 (1): 1626. 9 April 2019

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
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Nature Medicine 25 (4): 667-678. April 2019

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
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Nature Medicine 25 (4): 679-689. April 2019

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
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Nature Communications 10 (1): 1444. 29 March 2019

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
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Nature 567 (7749): 535-539. 28 March 2019

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
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Blood 133 (13): 1489-1494. 28 March 2019

PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.
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Genome Biology 20 (1): 59. 19 March 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
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Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
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R-loops enhance polycomb repression at a subset of developmental regulator genes.
Skourti-Stathaki, K. and Torlai Triglia, E. and Warburton, M. and Voigt, P. and Bird, A. and Pombo, A.
Molecular Cell 73 (5): 930-945. 7 March 2019

Microbial abundance, activity and population genomic profiling with mOTUs2.
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Nature Communications 10 (1): 1014. 4 March 2019

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
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Nature Communications 10 (1): 990. 1 March 2019

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
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Genome Biology 20 (1): 42. 21 February 2019

BCR-dependent lineage plasticity in mature B cells.
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Science 363 (6428): 748-753. 15 February 2019

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A. and Alt, S. and Ferreira, R.M.M. and Gribben, C. and Wang, V.M.Y. and Cotoi, C.G. and Salbreux, G. and Behrens, A.
Nature 566 (7742): 126-130. 7 February 2019

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H. and Georgakopoulou, A. and Psatha, N. and Li, C. and Capsali, C. and Samal, H.B. and Anagnostopoulos, A. and Ehrhardt, A. and Izsvák, Z. and Papayannopoulou, T. and Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129 (2): 598-615. 1 February 2019

Eleven loci with new reproducible genetic associations with allergic disease risk.
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Deciphering human ribonucleoprotein regulatory networks.
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Nucleic Acids Research 47 (2): 570-581. 25 January 2019