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High Impact Publications (Impact Factor > 10)

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eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Huerta-Cepas, J. and Szklarczyk, D. and Heller, D. and Hernández-Plaza, A. and Forslund, S.K. and Cook, H. and Mende, D.R. and Letunic, I. and Rattei, T. and Jensen, L.J. and von Mering, C. and Bork, P.
Nucleic Acids Research 12 November 2018 (In Press)

Potassium channel-based optogenetic silencing.
Bernal Sierra, Y.A. and Rost, B.R. and Pofahl, M. and Fernandes, A.M. and Kopton, R.A. and Moser, S. and Holtkamp, D. and Masala, N. and Beed, P. and Tukker, J.J. and Oldani, S. and Bönigk, W. and Kohl, P. and Baier, H. and Schneider-Warme, F. and Hegemann, P. and Beck, H. and Seifert, R. and Schmitz, D.
Nature Communications 9 (1): 4611. 5 November 2018

omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data.
Drewe-Boss, P. and Wessels, H.H. and Ohler, U.
Genome Biology 19 : 183. 1 November 2018

Nervous system regionalization entails axial allocation before neural differentiation.
Metzis, V. and Steinhauser, S. and Pakanavicius, E. and Gouti, M. and Stamataki, D. and Ivanovitch, K. and Watson, T. and Rayon, T. and Mousavy Gharavy, S.N. and Lovell-Badge, R. and Luscombe, N.M. and Briscoe, J.
Cell 175 (4): 1105-1118. 1 November 2018

Recovery of gut microbiota of healthy adults following antibiotic exposure.
Palleja, A. and Mikkelsen, K.H. and Forslund, S.K. and Kashani, A. and Allin, K.H. and Nielsen, T. and Hansen, T.H. and Liang, S. and Feng, Q. and Zhang, C. and Pyl, P.T. and Coelho, L.P. and Yang, H. and Wang, J. and Typas, A. and Nielsen, M.F. and Nielsen, H.B. and Bork, P. and Wang, J. and Vilsbøll, T. and Hansen, T. and Knop, F.K. and Arumugam, M. and Pedersen, O.
Nature Microbiology 3 : 1255-1265. November 2018

A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links.
Pedersen, H.K. and Forslund, S.K. and Gudmundsdottir, V. and Petersen, A.Ø. and Hildebrand, F. and Hyötyläinen, T. and Nielsen, T. and Hansen, T. and Bork, P. and Ehrlich, S.D. and Brunak, S. and Oresic, M. and Pedersen, O. and Nielsen, H.B.
Nature Protocols 31 October 2018 (In Press)

Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M. and Karabacak, A. and Glahs, A. and Kolundzic, E. and Hirsekorn, A. and Carda, A. and Tursun, B. and Zinzen, R.P. and Lacadie, S.A. and Ohler, U.
Nature Communications 9 (1): 4472. 26 October 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
Kabrani, E. and Chu, V.T. and Tasouri, E. and Sommermann, T. and Baßler, K. and Ulas, T. and Zenz, T. and Bullinger, L. and Schultze, J. and Rajewsky, K. and Sander, S.
Blood 17 October 2018 (In Press)

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B. and Nagy, G. and Czimmerer, Z. and Horvath, A. and Hammers, D.W. and Cuaranta-Monroy, I. and Poliska, S. and Tzerpos, P. and Kolostyak, Z. and Hays, T.T. and Patsalos, A. and Houtman, R. and Sauer, S. and Francois-Deleuze, J. and Rastinejad, F. and Balint, B.L. and Sweeney, H.L. and Nagy, L.
Immunity 49 (4): 615-626. 16 October 2018

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E. and Loud, M.C. and Daou, I. and Marshall, K.L. and Schwaller, F. and Kühnemund, J. and Francisco, A.G. and Keenan, W.T. and Dubin, A.E. and Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
Delgado-Benito, V. and Rosen, D.B. and Wang, Q. and Gazumyan, A. and Pai, J.A. and Oliveira, T.Y. and Sundaravinayagam, D. and Zhang, W. and Andreani, M. and Keller, L. and Kieffer-Kwon, K.R. and Pękowska, A. and Jung, S. and Driesner, M. and Subbotin, R.I. and Casellas, R. and Chait, B.T. and Nussenzweig, M.C. and Di Virgilio, M.
Molecular Cell 4 October 2018 (In Press)

Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K. and Milek, M. and Bogdanow, B. and Yasuda, T. and Kastelic, N. and Zauber, H. and Ishihama, Y. and Landthaler, M. and Selbach, M.
Molecular Cell 72 (1): 84-98. 4 October 2018

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
Kragesteen, B.K. and Spielmann, M. and Paliou, C. and Heinrich, V. and Schöpflin, R. and Esposito, A. and Annunziatella, C. and Bianco, S. and Chiariello, A.M. and Jerković, I. and Harabula, I. and Guckelberger, P. and Pechstein, M. and Wittler, L. and Chan, Wi.L. and Franke, M. and Lupiáñez, D.G. and Kraft, K. and Timmermann, B. and Vingron, M. and Visel, A. and Nicodemi, M. and Mundlos, S. and Andrey, G.
Nature Genetics 50 (10): 1463-1473. October 2018

Challenges and guidelines toward 4D nucleome data and model standards.
Marti-Renom, M.A. and Almouzni, G. and Bickmore, W.A. and Bystricky, K. and Cavalli, G. and Fraser, P. and Gasser, S.M. and Giorgetti, L. and Heard, E. and Nicodemi, M. and Nollmann, M. and Orozco, M. and Pombo, A. and Torres-Padilla, M.E.
Nature Genetics 50 (10): 1352-1358. October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn, J.D. and Miller, P.G. and Silver, A.J. and Sellar, R.S. and Bhatt, S. and Gibson, C. and McConkey, M. and Adams, D. and Mar, B. and Mertins, P. and Fereshetian, S. and Krug, K. and Zhu, H. and Letai, A. and Carr, S.A. and Doench, J. and Jaiswal, S. and Ebert, B.L.
Blood 132 (11): 1095-1105. 13 September 2018

mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A. and Buntru, A. and Schindler, F. and Hasenkopf, R. and Schulz, A. and Brusendorf, L. and Klockmeier, K. and Grelle, G. and McMahon, B. and Niederlechner, H. and Jansen, I. and Diez, L. and Edel, J. and Boeddrich, A. and Franklin, S.A. and Baldo, B. and Schnoegl, S. and Kunz, S. and Purfürst, B. and Gaertner, A. and Kampinga, H.H. and Morton, A.J. and Petersén, Å. and Kirstein, J. and Bates, G.P. and Wanker, E.E.
Molecular Cell 71 (5): 675-688. 6 September 2018

Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K. and Vogt, L. and Greber, B. and Diecke, S. and Boccaccini, A.R. and Scheibel, T. and Engel, F.B.
Advanced Functional Materials : 1803951. 6 September 2018 (In Press)

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T. and Braud, S. and Jüttner, R. and Voigt, B.C. and Paulick, K. and Sheean, M.E. and Klisch, C. and Gueneykaya, D. and Rathjen, F.G. and Geiger, J.R.P. and Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37 (17): e98858. 3 September 2018

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.
Arends, C.M. and Galan-Sousa, J. and Hoyer, K. and Chan, W. and Jäger, M. and Yoshida, K. and Seemann, R. and Noerenberg, D. and Waldhueter, N. and Fleischer-Notter, H. and Christen, F. and Schmitt, C.A. and Dörken, B. and Pelzer, U. and Sinn, M. and Zemojtel, T. and Ogawa, S. and Märdian, S. and Schreiber, A. and Kunitz, A. and Krüger, U. and Bullinger, L. and Mylonas, E. and Frick, M. and Damm, F.
Leukemia 32 (9): 1908-1919. September 2018

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Schleussner, N. and Merkel, O. and Costanza, M. and Liang, H.C. and Hummel, F. and Romagnani, C. and Durek, P. and Anagnostopoulos, I. and Hummel, M. and Jöhrens, K. and Niedobitek, A. and Griffin, P.R. and Piva, R. and Sczakiel, H.L. and Woessmann, W. and Damm-Welk, C. and Hinze, C. and Stoiber, D. and Gillissen, B. and Turner, S.D. and Kaergel, E. and von Hoff, L. and Grau, M. and Lenz, G. and Dörken, B. and Scheidereit, C. and Kenner, L. and Janz, M. and Mathas, S.
Leukemia 32 (9): 1994-2007. September 2018

Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
Tito, R.Y. and Chaffron, S. and Caenepeel, C. and Lima-Mendez, G. and Wang, J. and Vieira-Silva, S. and Falony, G. and Hildebrand, F. and Darzi, Y. and Rymenans, L. and Verspecht, C. and Bork, P. and Vermeire, S. and Joossens, M. and Raes, J.
Gut 31 August 2018 (In Press)

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D. and Schön, C. and Loddenkemper, C. and Lohneis, P. and Kühl, A.A. and Sommermann, T. and Blankenstein, T. and Willimsky, G.
Blood 132 (9): 924-934. 30 August 2018

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S. and Gohlke, U. and Broeker, N.K. and Roske, Y. and Heinemann, U. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140 (33): 10447-10455. 22 August 2018

Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J. and Noel, J.K. and Low, H.H.
Nature Communications 9 (1): 3345. 21 August 2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A. and Huang, J. and Györfi, A.H. and Matei, A.E. and Trinh-Minh, T. and Xu, X. and Li, Y.N. and Chen, C.W. and Lin, J. and Dees, C. and Beyer, C. and Gelse, K. and Zhang, Z.Y. and Bergmann, C. and Ramming, A. and Birchmeier, W. and Distler, O. and Schett, G. and Distler, J.H.W.
Nature Communications 9 (1): 3259. 14 August 2018

Structure and function of the global topsoil microbiome.
Bahram, M. and Hildebrand, F. and Forslund, S.K. and Anderson, J.L. and Soudzilovskaia, N.A. and Bodegom, P.M. and Bengtsson-Palme, J. and Anslan, S. and Coelho, L.P. and Harend, H. and Huerta-Cepas, J. and Medema, M.H. and Maltz, M.R. and Mundra, S. and Olsson, P.A. and Pent, M. and Põlme, S. and Sunagawa, S. and Ryberg, M. and Tedersoo, L. and Bork, P.
Nature 560 (7717): 233-237. 9 August 2018

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome.
Maass, P.G. and Weise, A. and Rittscher, K. and Lichtenwald, J. and Barutcu, A.R. and Liehr, T. and Aydin, A. and Wefeld-Neuenfeld, Y. and Pölsler, L. and Tinschert, S. and Rinn, J.L. and Luft, F.C. and Bähring, S.
EMBO Journal 37 (15): e96257. 1 August 2018

Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.
Gavvovidis, I. and Leisegang, M. and Willimsky, G. and Miller, N.J. and Nghiem, P. and Blankenstein, T.
Clinical Cancer Research 24 (15): 3644-3655. August 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage, J. and Standl, M. and Curtin, J.A. and Jessen, L.E. and Thorsen, J. and Tian, C. and Schoettler, N. and Flores, C. and Abdellaoui, A. and Ahluwalia, T.S. and Alves, A.C. and Amaral, A.F.S. and Antó, J.M. and Arnold, A. and Barreto-Luis, A. and Baurecht, H. and van Beijsterveldt, C.E.M. and Bleecker, E.R. and Bonàs-Guarch, S. and Boomsma, D.I. and Brix, S. and Bunyavanich, S. and Burchard, E.G. and Chen, Z. and Curjuric, I. and Custovic, A. and den Dekker, H.T. and Dharmage, S.C. and Dmitrieva, J. and Duijts, L. and Ege, M.J. and Gauderman, W.J. and Georges, M. and Gieger, C. and Gilliland, F. and Granell, R. and Gui, H. and Hansen, T. and Heinrich, J. and Henderson, J. and Hernandez-Pacheco, N. and Holt, P. and Imboden, M. and Jaddoe, V.W.V. and Jarvelin, M.R. and Jarvis, D.L. and Jensen, K.K. and Jónsdóttir, I. and Kabesch, M. and Kaprio, J. and Kumar, A. and Lee, Y.A. and Levin, A.M. and Li, X. and Lorenzo-Diaz, F. and Melén, E. and Mercader, J.M. and Meyers, D.A. and Myers, R. and Nicolae, D.L. and Nohr, E.A. and Palviainen, T. and Paternoster, L. and Pennell, C.E. and Pershagen, G. and Pino-Yanes, M. and Probst-Hensch, N.M. and Rüschendorf, F. and Simpson, A. and Stefansson, K. and Sunyer, J. and Sveinbjornsson, G. and Thiering, E. and Thompson, P.J. and Torrent, M. and Torrents, D. and Tung, J.Y. and Wang, C.A. and Weidinger, S. and Weiss, S. and Willemsen, G. and Williams, L.K. and Ober, C. and Hinds, D.A. and Ferreira, M.A. and Bisgaard, H. and Strachan, D.P. and Bønnelykke, K.
Nature Genetics 50 (8): 1072-1080. August 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B. and Hermes, R. and Colleoni, S. and Diecke, S. and Holtze, S. and Renfree, M.B. and Stejskal, J. and Hayashi, K. and Drukker, M. and Loi, P. and Göritz, F. and Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L. and Frainay, C. and Chazalviel, M. and Cabanettes, F. and Gloaguen, Y. and Camenen, E. and Merlet, B. and Heux, S. and Portais, J.C. and Poupin, N. and Vinson, F. and Jourdan, F.
Nucleic Acids Research 46 (W1): W495-W502. 2 July 2018

iPath3.0: interactive pathways explorer v3.
Darzi, Y. and Letunic, I. and Bork, P. and Yamada, T.
Nucleic Acids Research 46 (W1): W510-W513. 2 July 2018

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J. and Luong, T.T. and Tuffaha, R. and Musculus, K. and Auer, T. and Lian, X. and Daniel, C. and Zickler, D. and Boehme, B. and Sacherer, M. and Metzler, B. and Kuhl, D. and Gollasch, M. and Amann, K. and Müller, D.N. and Pieske, B. and Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128 (7): 3024-3040. 2 July 2018

Species-specific activity of antibacterial drug combinations.
Brochado, A.R. and Telzerow, A. and Bobonis, J. and Banzhaf, M. and Mateus, A. and Selkrig, J. and Huth, E. and Bassler, S. and Zamarreño Beas, J. and Zietek, M. and Ng, N. and Foerster, S. and Ezraty, B. and Py, B. and Barras, F. and Savitski, M.M. and Bork, P. and Göttig, S. and Typas, A.
Nature 559 (7713): 259-263. July 2018

Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Nature 559 (7713): 211-216. July 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S. and Zhou, J. and Liu, J.B. and Wu, Z. and Xu, X. and Li, T. and Xu, D. and Schumacher, S.E. and Puschhof, J. and McFarland, J. and Zou, C. and Dulak, A. and Henderson, L. and Xu, P. and O'Day, E. and Rendak, R. and Liao, W.L. and Cecchi, F. and Hembrough, T. and Schwartz, S. and Szeto, C. and Rustgi, A.K. and Wong, K.K. and Diehl, J.A. and Jensen, K. and Graziano, F. and Ruzzo, A. and Fereshetian, S. and Mertins, P. and Carr, S.A. and Beroukhim, R. and Nakamura, K. and Oki, E. and Watanabe, M. and Baba, H. and Imamura, Y. and Catenacci, D. and Bass, A.J.
Nature Medicine 24 (7): 968-977. July 2018

Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M. and Ferreira, D.G. and Batalha, V.L. and Marques-Morgado, I. and Coelho, J.E. and Pereira, P. and Gomes, R. and Pinto, A. and Carvalho, S. and Canas, P.M. and Cuvelier, L. and Buée-Scherrer, V. and Faivre, E. and Baqi, Y. and Müller, C.E. and Pimentel, J. and Schiffmann, S.N. and Buée, L. and Bader, M. and Outeiro, T.F. and Blum, D. and Cunha, R.A. and Marie, H. and Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 27 June 2018 (In Press)

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M. and Swinarski, M. and Meyer, A.M. and Müller, N.V. and Özcan, I. and Donat, S. and Burger, A. and Gilbert, S. and Mosimann, C. and Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

Pervasive protein thermal stability variation during the cell cycle.
Becher, I. and Andrés-Pons, A. and Romanov, N. and Stein, F. and Schramm, M. and Baudin, F. and Helm, D. and Kurzawa, N. and Mateus, A. and Mackmull, M.T. and Typas, A. and Müller, C.W. and Bork, P. and Beck, M. and Savitski, M.M.
Cell 173 (6): 1495-1507. 31 May 2018

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M. and Solana, J. and Wolf, F.A. and Ayoub, S. and Misios, A. and Glažar, P. and Obermayer, B. and Theis, F.J. and Kocks, C. and Rajewsky, N.
Science 360 (6391): eaaq1723. 25 May 2018

Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y. and Sabag, O. and Skversky, Y. and Spiro, A. and Steinberg, B. and Bernstein, D. and Wang, A. and Kieckhaefer, J. and Li, C. and Pikarsky, E. and Levin-Klein, R. and Goren, A. and Rajewsky, K. and Kaestner, K.H. and Cedar, H.
Nature Communications 9 (1): 2040. 23 May 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A. and Prummel, K.D. and Merks, A.M. and Mickoleit, M. and Brombacher, E.C. and Huisken, J. and Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B. and Nagy, G. and Horvath, A. and Czimmerer, Z. and Cuaranta-Monroy, I. and Poliska, S. and Hays, T.T. and Sauer, S. and Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46 (9): 4425-4439. 18 May 2018

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T. and Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9 (1): 1974. 17 May 2018

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M. and Gonzalez, E. and Teixeira da Costa, A.R. and Wask, L. and Gravenstein, I. and Pardo, M. and Pietzke, M. and Gurumurthy, R.K. and Angermann, J. and Laudeley, R. and Glage, S. and Meyer, M. and Chumduri, C. and Kempa, S. and Dinkel, K. and Unger, A. and Klebl, B. and Klos, A. and Meyer, T.F.
Cell Host & Microbe 23 (5): 661-671. 9 May 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L. and Alvarez-Martinez, M. and Luisier, R. and Cox, L.S. and Sodenkamp, J. and Hosking, C. and Pérez-Mazliah, D. and Whicher, C. and Kannan, Y. and Potempa, K. and Wu, X. and Bhaw, L. and Wende, H. and Sieweke, M.H. and Elgar, G. and Wilson, M. and Briscoe, J. and Metzis, V. and Langhorne, J. and Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars.
Spanjaard, B. and Hu, B. and Mitic, N. and Olivares-Chauvet, P. and Janjuha, S. and Ninov, N. and Junker, J.P.
Nature Biotechnology 36 (5): 469-473. May 2018

Eleven loci with new reproducible genetic associations with allergic disease risk.
Ferreira, M.A. and Vonk, J.M. and Baurecht, H. and Marenholz, I. and Tian, C. and Hoffman, J.D. and Helmer, Q. and Tillander, A. and Ullemar, V. and Lu, Y. and Rüschendorf, F. and Hinds, D.A. and Hübner, N. and Weidinger, S. and Magnusson, P.K. and Jorgenson, E. and Lee, Y.A. and Boomsma, D.I. and Karlsson, R. and Almqvist, C. and Koppelman, G.H. and Paternoster, L.
Journal of Allergy and Clinical Immunology 19 April 2018 (In Press)

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.
Turajlic, S. and Xu, H. and Litchfield, K. and Rowan, A. and Horswell, S. and Chambers, T. and O'Brien, T. and Lopez, J.I. and Watkins, T.B.K. and Nicol, D. and Stares, M. and Challacombe, B. and Hazell, S. and Chandra, A. and Mitchell, T.J. and Au, L. and Eichler-Jonsson, C. and Jabbar, F. and Soultati, A. and Chowdhury, S. and Rudman, S. and Lynch, J. and Fernando, A. and Stamp, G. and Nye, E. and Stewart, A. and Xing, W. and Smith, J.C. and Escudero, M. and Huffman, A. and Matthews, N. and Elgar, G. and Phillimore, B. and Costa, M. and Begum, S. and Ward, S. and Salm, M. and Boeing, S. and Fisher, R. and Spain, L. and Navas, C. and Grönroos, E. and Hobor, S. and Sharma, S. and Aurangzeb, I. and Lall, S. and Polson, A. and Varia, M. and Horsfield, C. and Fotiadis, N. and Pickering, L. and Schwarz, R.F. and Silva, B. and Herrero, J. and Luscombe, N.M. and Jamal-Hanjani, M. and Rosenthal, R. and Birkbak, N.J. and Wilson, G.A. and Pipek, O. and Ribli, D. and Krzystanek, M. and Csabai, I. and Szallasi, Z. and Gore, M. and McGranahan, N. and Van Loo, P. and Campbell, P. and Larkin, J. and Swanton, C.
Cell 173 (3): 595-610. 19 April 2018

Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo.
Jouhanneau, J.S. and Kremkow, J. and Poulet, J.F.A.
Nature Communications 9 (1): 1540. 18 April 2018

Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G. and Kim, Y. and de Almeida, P.E. and Termglinchan, V. and Diecke, S. and Shao, N.Y. and Wei, T.T. and Yi, H. and Dey, De. and Nelakanti, R. and Brouwer, T.P. and Paik, D.T. and Sagiv-Barfi, I. and Han, A. and Quax, P.H.A. and Hamming, J.F. and Levy, R. and Davis, M.M. and Wu, J.C.
Cell Stem Cell 22 (4): 501-513. 5 April 2018

Selective maternal seeding and environment shape the human gut microbiome.
Korpela, K. and Costea, P. and Coelho, L.P. and Kandels-Lewis, S. and Willemsen, G. and Boomsma, D.I. and Segata, N. and Bork, P.
Genome Research 28 (4): 561-568. April 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.
Tramontano, M. and Andrejev, S. and Pruteanu, M. and Klünemann, M. and Kuhn, M. and Galardini, M. and Jouhten, P. and Zelezniak, A. and Zeller, G. and Bork, P. and Typas, A. and Patil, K.R.
Nature Microbiology 3 (3): 514-522. April 2018

Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier, L. and Pruteanu, M. and Kuhn, M. and Zeller, G. and Telzerow, A. and Anderson, E.E. and Brochado, A.R. and Fernandez, K.C. and Dose, H. and Mori, H. and Patil, K.R. and Bork, P. and Typas, A.
Nature 555 (7698): 623-628. 29 March 2018

SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K. and Kranz, A. and Fohgrub, J. and Jolly, A. and Bledau, A.S. and Di Virgilio, M. and Lesche, M. and Dahl, A. and Höfer, T. and Stewart, A.F. and Waskow, C.
Blood 131 (12): 1311-1324. 22 March 2018

Transposase-DNA complex structures reveal mechanisms for conjugative transposition of antibiotic resistance.
Rubio-Cosials, A. and Schulz, E.C. and Lambertsen, L. and Smyshlyaev, G. and Rojas-Cordova, C. and Forslund, K. and Karaca, E. and Bebel, A. and Bork, P. and Barabas, O.
Cell 173 (1): 208-220. 22 March 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Voltage gating of mechanosensitive PIEZO channels.
Moroni, M. and Servin-Vences, M.R. and Fleischer, R. and Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9 (1): 1096. 15 March 2018

High-throughput identification of RNA nuclear enrichment sequences.
Shukla, C.J. and McCorkindale, A.L. and Gerhardinger, C. and Korthauer, K.D. and Cabili, M.N. and Shechner, D.M. and Irizarry, R.A. and Maass, P. and Rinn, J.L.
EMBO Journal 37 : e98452. 15 March 2018

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Fernandes-Rosa, F.L. and Daniil, G. and Orozco, I.J. and Göppner, C. and El Zein, R. and Jain, V. and Boulkroun, S. and Jeunemaitre, X. and Amar, L. and Lefebvre, H. and Schwarzmayr, T. and Strom, T.M. and Jentsch, T.J. and Zennaro, M.C.
Nature Genetics 50 (3): 355-361. March 2018

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Scholl, U.I. and Stölting, G. and Schewe, J. and Thiel, A. and Tan, H. and Nelson-Williams, C. and Vichot, A.A. and Jin, S.C. and Loring, E. and Untiet, V. and Yoo, T. and Choi, J. and Xu, S. and Wu, A. and Kirchner, M. and Mertins, P. and Rump, L.C. and Onder, A.M. and Gamble, C. and McKenney, D. and Lash, R.W. and Jones, D.P. and Chune, G. and Gagliardi, P. and Choi, M. and Gordon, R. and Stowasser, M. and Fahlke, C. and Lifton, R.P.
Nature Genetics 50 (3): 349-354. March 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability.
Dawes, J.M. and Weir, G.A. and Middleton, S.J. and Patel, R. and Chisholm, K.I. and Pettingill, P. and Peck, L.J. and Sheridan, J. and Shakir, A. and Jacobson, L. and Gutierrez-Mecinas, M. and Galino, J. and Walcher, J. and Kühnemund, J. and Kuehn, H. and Sanna, M.D. and Lang, B. and Clark, A.J. and Themistocleous, A.C. and Iwagaki, N. and West, S.J. and Werynska, K. and Carroll, L. and Trendafilova, T. and Menassa, D.A. and Giannoccaro, M.P. and Coutinho, E. and Cervellini, I. and Tewari, D. and Buckley, C. and Leite, M.I. and Wildner, H. and Zeilhofer, H.U. and Peles, E. and Todd, A.J. and McMahon, S.B. and Dickenson, A.H. and Lewin, G.R. and Vincent, A. and Bennett, D.L.
Neuron 97 (4): 806-822. 21 February 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y. and Schleich, K. and Yue, B. and Ji, S. and Lohneis, P. and Kemper, K. and Silvis, M.S. and Qutob, N. and van Rooijen, E. and Werner-Klein, M. and Li, L. and Dhawan, D. and Meierjohann, S. and Reimann, M. and Elkahloun, A. and Treitschke, S. and Dörken, B. and Speck, C. and Mallette, F.A. and Zon, L.I. and Holmen, S.L. and Peeper, D.S. and Samuels, Y. and Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Precisely timed nicotinic activation drives SST inhibition in neocortical circuits.
Urban-Ciecko, J. and Jouhanneau, J.S. and Myal, S.E. and Poulet, J.F.A. and Barth, A.L.
Neuron 97 (3): 611-625. 7 February 2018

The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
Althof, N. and Goetzke, C.C. and Kespohl, M. and Voss, K. and Heuser, A. and Pinkert, S. and Kaya, Z. and Klingel, K. and Beling, A.
EMBO Molecular Medicine 10 (2): 200-218. 1 February 2018

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer, E.E. and Stuhlmann, T. and Weinert, S. and Haan, E. and Van Esch, H. and Holvoet, M. and Boyle, J. and Leffler, M. and Raynaud, M. and Moraine, C. and van Bokhoven, H. and Kleefstra, T. and Kahrizi, K. and Najmabadi, H. and Ropers, H.H. and Delgado, M.R. and Sirsi, D. and Golla, S. and Sommer, A. and Pietryga, M.P. and Chung, W.K. and Wynn, J. and Rohena, L. and Bernardo, E. and Hamlin, D. and Faux, B.M. and Grange, D.K. and Manwaring, L. and Tolmie, J. and Joss, S. and Cobben, J.M. and Duijkers, F.A.M. and Goehringer, J.M. and Challman, T.D. and Hennig, F. and Fischer, U. and Grimme, A. and Suckow, V. and Musante, L. and Nicholl, J. and Shaw, M. and Lodh, S.P. and Niu, Z. and Rosenfeld, J.A. and Stankiewicz, P. and Jentsch, T.J. and Gecz, J. and Field, M. and Kalscheuer, V.M.
Molecular Psychiatry 23 (2): 222-230. February 2018

A global ocean atlas of eukaryotic genes.
Carradec, Q. and Pelletier, E. and Da Silva, C. and Alberti, A. and Seeleuthner, Y. and Blanc-Mathieu, R. and Lima-Mendez, G. and Rocha, F. and Tirichine, L. and Labadie, K. and Kirilovsky, A. and Bertrand, A. and Engelen, S. and Madoui, M.A. and Méheust, R. and Poulain, J. and Romac, S. and Richter, D.J. and Yoshikawa, G. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Jaillon, O. and Aury, J.M. and Karsenti, E. and Sullivan, M.B. and Sunagawa, S. and Bork, P. and Not, F. and Hingamp, P. and Raes, J. and Guidi, L. and Ogata, H. and De Vargas, C. and Iudicone, D. and Bowler, C. and Wincker, P.
Nature Communications 9 (1): 373. 25 January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A. and Buntru, A. and Arnsburg, K. and Ast, A. and Iburg, M. and Juenemann, K. and Pigazzini, M.L. and Mlody, B. and Puchkov, D. and Priller, J. and Wanker, E.E. and Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z. and Daniel, B. and Horvath, A. and Rückerl, D. and Nagy, G. and Kiss, M. and Peloquin, M. and Budai, M.M. and Cuaranta-Monroy, I. and Simandi, Z. and Steiner, L. and Nagy, B. and Poliska, S. and Banko, C. and Bacso, Z. and Schulman, I.G. and Sauer, S. and Deleuze, J.F. and Allen, J.E. and Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

MVP: a microbe-phage interaction database.
Gao, N.L. and Zhang, C. and Zhang, Z. and Hu, S. and Lercher, M.J. and Zhao, X.M. and Bork, P. and Liu, Z. and Chen, W.H.
Nucleic Acids Research 46 (D1): D700-D707. 4 January 2018

Genetics of intellectual disability in consanguineous families.
Hu, H. and Kahrizi, K. and Musante, L. and Fattahi, Z. and Herwig, R. and Hosseini, M. and Oppitz, C. and Abedini, S.S. and Suckow, V. and Larti, F. and Beheshtian, M. and Lipkowitz, B. and Akhtarkhavari, T. and Mehvari, S. and Otto, S. and Mohseni, M. and Arzhangi, S. and Jamali, P. and Mojahedi, F. and Taghdiri, M. and Papari, E. and Soltani Banavandi, M.J. and Akbari, S. and Tonekaboni, S.H. and Dehghani, H. and Ebrahimpour, M.R. and Bader, I. and Davarnia, B. and Cohen, M. and Khodaei, H. and Albrecht, B. and Azimi, S. and Zirn, B. and Bastami, M. and Wieczorek, D. and Bahrami, G. and Keleman, K. and Vahid, L.N. and Tzschach, A. and Gärtner, J. and Gillessen-Kaesbach, G. and Varaghchi, J.R. and Timmermann, B. and Pourfatemi, F. and Jankhah, A. and Chen, W. and Nikuei, P. and Kalscheuer, V.M. and Oladnabi, M. and Wienker, T.F. and Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 4 January 2018 (In Press)

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M. and Klinger, B. and Klünemann, M. and Sieber, A. and Uhlitz, F. and Sauer, S. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F. and Margaritte-Jeannin, P. and Barnes, K.C. and Cookson, W.O.C. and Altmueller, J. and Ang, W. and Barr, R.G. and Beaty, T.H. and Becker, A.B. and Beilby, J. and Bisgaard, H. and Bjornsdottir, U.S. and Bleecker, E. and Bonnelykke, K. and Boomsma, D.I. and Bouzigon, E. and Brightling, C.E. and Brossard, M. and Brusselle, G.G. and Burchard, E. and Burkart, K.M. and Bush, A. and Chan-Yeung, M. and Chung, K.F. and Couto Alves, A. and Curtin, J.A. and Custovic, A. and Daley, D. and de Jongste, J.C. and Del-Rio-Navarro, B.E. and Donohue, K.M. and Duijts, L. and Eng, C. and Eriksson, J.G. and Farrall, M. and Fedorova, Y. and Feenstra, B. and Ferreira, M.A. and Freidin, M.B. and Gajdos, Z. and Gauderman, J. and Gehring, U. and Geller, F. and Genuneit, J. and Gharib, S.A and Gilliland, F. and Granell, R. and Graves, P.E. and Gudbjartsson, D.F. and Haahtela, T. and Heckbert, S.R. and Heederik, D. and Heinrich, J. and Helioevaara, M. and Henderson, J. and Himes, B.E. and Hirose, H. and Hirschhorn, J.N. and Hofman, A. and Holt, P. and Hottenga, J. and Hudson, T.J. and Hui, J. and Imboden, M. and Ivanov, V. and Jaddoe, V.W.V. and James, A. and Janson, C. and Jarvelin, M.R. and Jarvis, D. and Jones, G. and Jonsdottir, I. and Jousilahti, P. and Kabesch, M. and Kähönen, M. and Kantor, D.B. and Karunas, A.S. and Khusnutdinova, E. and Koppelman, G.H. and Kozyrskyj, A.L. and Kreiner, E. and Kubo, M. and Kumar, R. and Kumar, A. and Kuokkanen, M. and Lahousse, L. and Laitinen, T. and Laprise, C. and Lathrop, M. and Lau, S. and Lee, Y.A. and Lehtimaeki, T. and Letort, S. and Levin, A.M. and Li, G. and Liang, L. and Loehr, L.R. and London, S.J. and Loth, D.W. and Manichaikul, A. and Marenholz, I. and Martinez, F.J. and Matheson, M.C. and Mathias, R.A. and Matsumoto, K. and Mbarek, H. and McArdle, W.L. and Melbye, M. and Melen, E. and Meyers, D. and Michel, S. and Mohamdi, H. and Musk, A.W. and Myers, R.A. and Nieuwenhuis, M.A.E. and Noguchi, E. and O'Connor, G.T. and Ogorodova, L.M. and Palmer, C.D. and Palotie, A. and Park, J.E. and Pennell, C.E. and Pershagen, G. and Polonikov, A. and Postma, D.S. and Probst-Hensch, N. and Puzyrev, V.P. and Raby, B.A. and Raitakari, O.T. and Ramasamy, A. and Rich, S.S. and Robertson, C.F. and Romieu, I. and Salam, M.T. and Salomaa, V. and Schluenssen, V. and Scott, R. and Selivanova, P.A. and Sigsgaard, T. and Simpson, A. and Siroux, V. and Smith, L.J. and Solodilova, M. and Standl, M. and Stefansson, K. and Strachan, D.P. and Stricker, B.H. and Takahashi, A. and Thompson, P.J. and Thorleifsson, G. and Thorsteinsdottir, U. and Tiesler, C.M.T. and Torgerson, D.G. and Tsunoda, T. and Uitterlinden, A.G. and van der Valk, R.J.P. and Vaysse, A. and Vedantam, S. and von Berg, A. and von Mutius, E. and Vonk, J.M. and Waage, J. and Wareham, N.J. and Weiss, S.T. and White, W.B. and Wickman, M. and Widén, E. and Willemsen, G. and Williams, L.K. and Wouters, I.M. and Yang, J.J. and Zhao, J.H. and Moffatt, M.F. and Ober, C. and Nicolae, D.L.
Nature Genetics 50 (1): 42-53. January 2018

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.
Verduci, L. and Ferraiuolo, M. and Sacconi, A. and Ganci, F. and Vitale, J. and Colombo, T. and Paci, P. and Strano, S. and Macino, G. and Rajewsky, N. and Blandino, G.
Genome Biology 18 (1): 237. 20 December 2017

Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M. and Gallion, J. and Picard, L.P. and Wilkins, A.D. and Le Gouill, C. and Audet, M. and Stallaert, W. and Lohse, M.J. and Kimmel, M. and Lichtarge, O. and Bouvier, M.
Nature Communications 8 (1): 2169. 18 December 2017

IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S. and Viswanathan, S. and Widjaja, A.A. and Lim, W.W. and Moreno-Moral, A. and DeLaughter, D.M. and Ng, B. and Patone, G. and Chow, K. and Khin, E. and Tan, J. and Chothani, S.P. and Ye, L. and Rackham, O.J. and Ko, N.S. and Sahib, N.E. and Pua, C.J. and Zhen, N.T. and Xie, C. and Wang, M. and Maatz, H. and Lim, S. and Saar, K. and Blachut, S. and Petretto, E. and Schmidt, S. and Putoczki, T. and Guimarães-Camboa, N. and Wakimoto, H. and van Heesch, S. and Sigmundsson, K. and Lim, S.L. and Soon, J.L. and Chao, V.T. and Chua, Y.L. and Tan, T.E. and Evans, S.M. and Loh, Y.J. and Jamal, M.H. and Ong, K.K. and Chua, K.C. and Ong, B.H. and Chakaramakkil, M.J. and Seidman, J.G. and Seidman, C.E. and Hubner, N. and Sin, K.Y. and Cook, S.A.
Nature 552 (7683): 110-115. 7 December 2017

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F. and Haas, J. and Zhu, F. and Geier, C. and Kayvanpour, E. and Liss, M. and Lai, A. and Frese, K. and Pribe-Wolferts, R. and Amr, A. and Li, D.T. and Samani, O.S. and Carstensen, A. and Bordalo, D.M. and Müller, M. and Fischer, C. and Shao, J. and Wang, J. and Nie, M. and Yuan, L. and Haßfeld, S. and Schwartz, C. and Zhou, M. and Zhou, Z. and Shu, Y. and Wang, M. and Huang, K. and Zeng, Q. and Cheng, L. and Fehlmann, T. and Ehlermann, P. and Keller, A. and Dieterich, C. and Streckfuß-Bömeke, K. and Liao, Y. and Gotthardt, M. and Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y. and Zhao, Y. and Jiang, L.L. and Li, X. and Liu, Y. and Sun, Y. and Piña-Crespo, J.C. and Zhu, B. and Masliah, E. and Willnow, T.E. and Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214 (12): 3669-3685. 4 December 2017

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A. and Dejanovic, B. and Hetsch, F. and Semtner, M. and Fusca, D. and Arjune, S. and Santamaria-Araujo, J.A. and Winkelmann, A. and Ayton, S. and Bush, A.I. and Kloppenburg, P. and Meier, J.C. and Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127 (12): 4365-4378. 1 December 2017

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Mathivet, T. and Bouleti, C. and Van Woensel, M. and Stanchi, F. and Verschuere, T. and Phng, L.K. and Dejaegher, J. and Balcer, M. and Matsumoto, K. and Georgieva, P.B. and Belmans, J. and Sciot, R. and Stockmann, C. and Mazzone, M. and De Vleeschouwer, S. and Gerhardt, H.
EMBO Molecular Medicine 9 (12): 1629-1645. 1 December 2017

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.
Eichenauer, D.A. and Plütschow, A. and Kreissl, S. and Sökler, M. and Hellmuth, J.C. and Meissner, J. and Mathas, S. and Topp, M.S. and Behringer, K. and Klapper, W. and Kuhnert, G. and Dietlein, M. and Kobe, C. and Fuchs, M. and Diehl, V. and Engert, A. and Borchmann, P.
Lancet Oncology 18 (12): 1680-1687. December 2017

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Nature Communications 8 (1): 1525. 15 November 2017

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Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
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ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
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Towards standards for human fecal sample processing in metagenomic studies.
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Nature Biotechnology 35 (11): 1069-1076. November 2017

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
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Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
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BMJ 359 : j4761. 31 October 2017

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
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Genome Biology 18 (1): 209. 31 October 2017

McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
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Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
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Nature 550 (7677): 543-547. 26 October 2017

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
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Nature Communications 8 (1): 1056. 20 October 2017

The Drosophila embryo at single-cell transcriptome resolution.
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Science 358 (6360): 194-199. 13 October 2017

Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.
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A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
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Nature 550 (7674): 114-118. 5 October 2017

Developmental origin and maintenance of distinct testicular macrophage populations.
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Journal of Experimental Medicine 214 (10): 2829-2841. 2 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
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Science 357 (6357): eaam8526. 22 September 2017

RNA localization is a key determinant of neurite-enriched proteome.
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Nature Communications 8 (1): 583. 19 September 2017

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
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Genome Biology 18 (1): 170. 14 September 2017

A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
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Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S. and Witte, N. and Weber, P. and Goehring, I. and Tolkachov, A. and von Loeffelholz, C. and Döcke, S. and Bauer, M. and Stockmann, M. and Pfeiffer, A.F.H. and Birkenfeld, A.L. and Pietzke, M. and Kempa, S. and Muenzner, M. and Schupp, M.
Nature Communications 8 (1): 384. 30 August 2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
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Nature 548 (7668): 456-460. 24 August 2017

SIRT1 regulates macrophage self-renewal.
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EMBO Journal 36 (16): 2353-2372. 15 August 2017

Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C. and Werner, A. and John, D. and Boeckel, J.-N. and Melissari, M.-T. and Grote, P. and Glaser, S.F. and Demolli, S. and Uchida, S. and Michalik, K.M. and Meder, B. and Katus, H.A. and Haas, J. and Chen, W. and Pullamsetti, S.S. and Seeger, W. and Zeiher, A.M. and Dimmeler, S. and Zehendner, C.M.
Circulation Research 121 (4): 368-375. 4 August 2017

Fast genome-wide functional annotation through orthology assignment by eggNOG-mapper.
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Molecular Biology and Evolution 34 (8): 2115-2122. 1 August 2017

Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies.
Rohr, U.P. and Herrmann, P. and Ilm, K. and Zhang, H. and Lohmann, S. and Reiser, A. and Muranyi, A. and Smith, J. and Burock, S. and Osterland, M. and Leith, K. and Singh, S. and Brunhoeber, P. and Bowermaster, R. and Tie, J. and Christie, M. and Wong, H.L. and Waring, P. and Shanmugam, K. and Gibbs, P. and Stein, U.
Annals of Oncology 28 (8): 1869-1875. 1 August 2017

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
Herce, H.D. and Schumacher, D. and Schneider, A.F.L. and Ludwig, A.K. and Mann, F.A. and Fillies, M. and Kasper, M.-A. and Reinke, S. and Krause, E. and Leonhardt, H. and Cardoso, M.C. and Hackenberger, C.P.R.
Nature Chemistry 9 (8): 762-771. August 2017

DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M. and Imami, K. and Mukherjee, N. and De Bortoli, F. and Zinnall, U. and Hazapis, O. and Trahan, C. and Oeffinger, M. and Heyd, F. and Ohler, U. and Selbach, M. and Landthaler, M.
Genome Research 27 (8): 1344-1359. August 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T. and Yan, X. and Kononenko, N.L. and Ku, M.C. and Song, K. and Ferrarese, L. and Tarallo, V. and Puchkov, D. and Kochlamazashvili, G. and Brachs, S. and Varela, L. and Szigeti-Buck, K. and Yi, C.X. and Schriever, S.C. and Tattikota, S.G. and Carlo, A.S. and Moroni, M. and Siemens, J. and Heuser, A. and van der Weyden, L. and Birkenfeld, A.L. and Niendorf, T. and Poulet, J.F.A. and Horvath, T.L. and Tschöp, M.H. and Heinig, M. and Trajkovski, M. and Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V. and Birdsey, G.M. and Peghaire, C. and Pitulescu, M.E. and Dufton, N.P. and Yang, Y. and Weinberg, I. and Osuna Almagro, L. and Payne, L. and Mason, J.C. and Gerhardt, H. and Adams, R.H. and Randi, A.M.
Nature Communications 8 : 16002. 11 July 2017

The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
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EMBO Journal 36 (13): 1854-1868. 3 July 2017

Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
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Journal of Experimental Medicine 214 (7): 2089-2101. 3 July 2017

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
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Nucleic Acids Research 45 (W1): W560-W566. 3 July 2017

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J. and Novitzky-Basso, I. and Thiriot, A. and Casanova-Acebes, M. and Bianchini, M. and Etheridge, S.L. and Hub, E. and Nitz, K. and Artinger, K. and Eller, K. and Caamano, J. and Ruelicke, T. and Moss, P. and Megens, R.T.A. and von Andrian, U.H. and Hidalgo, A. and Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.
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Leukemia 31 (7): 1547-1554. July 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.
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Nature Communications 8 (1): 36. 26 June 2017

Identification of the elementary structural units of the DNA damage response.
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Nature Communications 8 : 15760. 12 June 2017

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
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Nature 546 (7657): 302-306. 8 June 2017

RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
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Nucleic Acids Research 45 (10): e91. 2 June 2017

Tracking the evolution of non-small-cell lung cancer.
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New England Journal of Medicine 376 (22): 2109-2121. 1 June 2017

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.
Barbieri, M. and Xie, S.Q. and Torlai Triglia, E. and Chiariello, A.M. and Bianco, S. and de Santiago, I. and Branco, M.R. and Rueda, D. and Nicodemi, M. and Pombo, A.
Nature Structural & Molecular Biology 24 (6): 515-524. June 2017

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Tay, T.L. and Mai, D. and Dautzenberg, J. and Fernández-Klett, F. and Lin, G. and Sagar, D.M. and Datta, M. and Drougard, A. and Stempfl, T. and Ardura-Fabregat, A. and Staszewski, O. and Margineanu, A. and Sporbert, A. and Steinmetz, L.M. and Pospisilik, J.A. and Jung, S. and Priller, J. and Grün, D. and Ronneberger, O. and Prinz, M.
Nature Neuroscience 20 (6): 793-803. June 2017

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M. and Zerbes, R.M. and Rampelt, H. and Kunz, S. and Xavier, A.H. and Purfürst, B. and Lilie, H. and Pfanner, N. and van der Laan, M. and Daumke, O.
Nature Communications 8 : 15258. 31 May 2017

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Nature 545 (7655): 446-451. 25 May 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. and Schönheit, J. and Giladi, A. and David, E. and Lara-Astiaso, D. and Lorenzo-Vivas, E. and Paul, F. and Chappell-Maor, L. and Priller, J. and Leutz, A. and Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I. and Termglinchan, V. and Cepeda, D.A. and Lee, J. and Diecke, S. and Hendel, A. and Itzhaki, I. and Ameen, M. and Shrestha, R. and Wu, H. and Ma, N. and Shao, N.Y. and Seeger, T. and Woo, N.A. and Wilson, K.D. and Matsa, E. and Porteus, M.H. and Sebastiano, V. and Wu, J.C.
Circulation Research 120 (10): 1561-1571. 12 May 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K. and Daub, S. and Zhang, Y. and Klein, J. D. and Nakano, D. and Pedchenko, T. and Lantier, L. and LaRocque, L.M. and Marton, A. and Neubert, P. and Schröder, A. and Rakova, N. and Jantsch, J. and Dikalova, A.E. and Dikalov, S.I. and Harrison, D.G. and Müller, D.N. and Nishiyama, A. and Rauh, M. and Harris, R. C. and Luft, F.C. and Wassermann, D.H. and Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127 (5): 1944-1959. 1 May 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
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Journal of Clinical Investigation 127 (5): 1932-1943. 1 May 2017

Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
Vöpel, T. and Bravo-Rodriguez, K. and Mittal, S. and Vachharajani, S. and Gnutt, D. and Sharma, A. and Steinhof, A. and Fatoba, O. and Ellrichmann, G. and Nshanian, M. and Heid, C. and Loo, J.A. and Klärner, F.-G. and Schrader, T. and Bitan, G. and Wanker, E.E. and Ebbinghaus, S. and Sanchez-Garcia, E.
Journal of the American Chemical Society 139 (16): 5640-5643. 26 April 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S. and Zharkov, D.O. and Stahl, J. and Gopanenko, Al.V. and Tupikin, A.E. and Kabilov, M.R. and Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45 (7): 3833-3843. 20 April 2017

Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.
Legnini, I. and Di Timoteo, G. and Rossi, F. and Morlando, M. and Briganti, F. and Sthandier, O. and Fatica, A. and Santini, T. and Andronache, A. and Wade, M. and Laneve, P. and Rajewsky, N. and Bozzoni, I.
Molecular Cell 66 (1): 22-37.e9. 6 April 2017

Translation of circRNAs.
Pamudurti, NR. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Initiation of acute graft-versus-host disease by angiogenesis.
Riesner, K. and Shi, Y. and Jacobi, A. and Kräter, M. and Kalupa, M. and McGearey, A. and Mertlitz, S. and Cordes, S. and Schrezenmeier, J.F. and Mengwasser, J. and Westphal, S. and Perez-Hernandez, D. and Schmitt, C. and Dittmar, G. and Guck, J. and Penack, O.
Blood 129 (14): 2021-2032. 6 April 2017

Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing, S. and Rudnik, S. and Damme, M. and Luellmann-Rauch, R. and Ichihara, A. and Kornak, U. and Eskelinen, E.L. and Jabs, S. and Heeren, J. and De Brabander, J.K. and Haas, A. and Saftig, P.
Autophagy 13 (4): 670-685. April 2017

Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie, R.A. and Scialdone, A. and Schueler, M. and Kraemer, D.C.A. and Chotalia, M. and Xie, S.Q. and Barbieri, M. and de Santiago, I. and Lavitas, L.M. and Branco, M.R. and Fraser, J. and Dostie, J. and Game, L. and Dillon, N. and Edwards, P.A.W. and Nicodemi, M. and Pombo, A.
Nature 543 (7646): 519-524. 23 March 2017

Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O. and de Jong, T. and Mata-Cabana, A. and Kudron, M. and Zaini, M.A. and Aprile, F.A. and Seinstra, R.I. and Stroo, E. and Prins, R.W. and Martineau, C.N. and Wang, H.H. and Hogewerf, Wytse and Steinhof, A. and Wanker, E.E. and Vendruscolo, M. and Calkhoven, C.F. and Reinke, V. and Guryev, V. and Nollen, E.A.A.
Molecular Cell 65 (6): 1096-1108. 16 March 2017

The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association.
Mancia, G. and Oparil, S. and Whelton, P.K. and McKee, M. and Dominiczak, A. and Luft, F.C. and AlHabib, K. and Lanas, F. and Damasceno, A. and Prabhakaran, D. and La Torre, G. and Weber, M. and O'Donnell, M. and Smith, S.C. and Narula, J.
European Heart Journal 38 (10): 712-719. 7 March 2017

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D. and Hummel, F. and Richter, J. and Giefing, M. and Hartmann, S. and Hansmann, M.L. and Kreher, S. and Köchert, K. and Krappmann, D. and Klapper, W. and Hummel, M. and Wenzel, S.S. and Lenz, G. and Janz, M. and Dörken, B. and Siebert, R. and Mathas, S.
Leukemia 31 (3): 602-613. March 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N. and Naumann, H. and Ruzittu, S. and Mah, N. and Pongrac, I.M. and Cozzitorto, C. and Hommel, A. and Andrade-Navarro, M.A. and Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells.
Velasco, S. and Ibrahim, M.M. and Kakumanu, A. and Garipler, G. and Aydin, B. and Al-Sayegh, M.A. and Hirsekorn, A. and Abdul-Rahman, F. and Satija, R. and Ohler, U. and Mahony, S. and Mazzoni, E.O.
Cell Stem Cell 20 (2): 205-217. 2 February 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C. and Pifferi, S. and Picci, C. and Gök, C. and Hoffmann, D. and Bali, K.K. and Lampe, A. and Lapatsina, L. and Fleischer, R. and Smith, E.S.J. and Bégay, V. and Moroni, M. and Estebanez, L. and Kühnemund, J. and Walcher, J. and Specker, E. and Neuenschwander, M. and von Kries, J.P. and Haucke, V. and Kuner, R. and Poulet, J.F.A. and Schmoranzer, J. and Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S. and Childs, L.H. and Aust, D. and Heim, D. and Melching, F. and Oliveira, C. and Wolf, T. and Durek, P. and Schumacher, D. and Blaeker, H. and von Winterfeld, M. and Gastl, B. and Moehr, K. and Menne, A. and Zeugner, S. and Redmer, T. and Lenze, D. and Tierling, S. and Moebs, M. and Weichert, W. and Folprecht, G. and Blanc, E. and Beule, D. and Schaefer, R. and Morkel, M. and Klauschen, F. and Leser, U. and Sers, C.
Nature Communications 8 : 14093. 25 January 2017

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M. and Kirchner, M. and Aharoni, R. and Ciolli Mattioli, C. and van den Bruck, D. and Gutkovitch, N. and Modepalli, V. and Selbach, M. and Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45 (2): 938-950. 25 January 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 12 January 2017

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Dehghani Amirabad, A. and Behjati Ardakani, F. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
Nucleic Acids Research 45 (1): 54-66. 9 January 2017

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y. and Pryputniewicz-Dobrinska, D. and Nagy, E.E. and Kaufman, C.D. and Singh, M. and Yant, S. and Wang, J. and Dalda, A. and Kay, M.A. and Ivics, Z. and Izsvák, Z.
Nucleic Acids Research 45 (1): 311-326. 9 January 2017

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A. and Gorham, L. and Dhandapani, R. and Prato, V. and Taberner, F.J. and Wende, H. and Gangadharan, V. and Birchmeier, C. and Heppenstall, P.A. and Lechner, S.G.
Neuron 93 (1): 179-193. 4 January 2017

OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines.
Chen, W.H. and Lu, G. and Chen, X. and Zhao, X.M. and Bork, P.
Nucleic Acids Research 45 (D1): D940-D944. 4 January 2017

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
Mende, D.R. and Letunic, I. and Huerta-Cepas, J. and Li, S.S. and Forslund, K. and Sunagawa, S. and Bork, P.
Nucleic Acids Research 45 (D1): D529-D534. 4 January 2017

The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Szklarczyk, D. and Morris, J.H. and Cook, H. and Kuhn, M. and Wyder, S. and Simonovic, M. and Santos, A. and Doncheva, N.T. and Roth, A. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 45 (D1): D362-D368. 4 January 2017

Integrative classification of human coding and noncoding genes through RNA metabolism profiles.
Mukherjee, N. and Calviello, L. and Hirsekorn, A. and de Pretis, S. and Pelizzola, M. and Ohler, U.
Nature Structural & Molecular Biology 24 (1): 86-96. January 2017

Titin-truncating variants affect heart function in disease cohorts and the general population.
Schafer, S. and de Marvao, A. and Adami, E. and Fiedler, L.R. and Ng, B. and Khin, E. and Rackham, O.J.L. and van Heesch, S. and Pua, C.J. and Kui, M. and Walsh, R. and Tayal, U. and Prasad, S.K. and Dawes, T.J.W. and Ko, N.S.J. and Sim, D. and Chan, L.L.H. and Chin, C.W.L. and Mazzarotto, F. and Barton, P.J. and Kreuchwig, F. and de Kleijn, D.P.V. and Totman, T. and Biffi, C. and Tee, N. and Rueckert, D. and Schneider, V. and Faber, A. and Regitz-Zagrosek, V. and Seidman, J.G. and Seidman, C.E. and Linke, W.A. and Kovalik, J.P. and O'Regan, D. and Ware, J.S. and Hubner, N. and Cook, S.A.
Nature Genetics 49 (1): 46-53. January 2017

Scattering compensation by focus scanning holographic aberration probing (F-SHARP).
Papadopoulos, I.N. and Jouhanneau, J.S. and Poulet, J.F.A. and Judkewitz, B.
Nature Photonics 2017 (In Press)

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S. and Bolcho, U. and Molgaard, S. and Bøggild, S. and Vaegter, C.B. and Smith, A.H. and Nieto-Gonzalez, J.L. and Ovesen, P.L. and Pedersen, L.F. and Fjorback, A.N. and Kjolby, M. and Login, H. and Holm, M.M. and Andersen, O.M. and Nyengaard, J.R. and Willnow, T.E. and Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21 (12): 1740-1751. December 2016

DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L. and Nanda, I. and Evangelou, K. and Nikolova, T. and Horn, V. and Sagar, and Erny, D. and Stefanowski, J. and Rogell, L. and Klein, C. and Gharun, K. and Follo, M. and Seidl, M. and Kremer, B. and Münke, N. and Senges, J. and Fliegauf, M. and Aschman, T. and Pfeifer, D. and Sarrazin, S. and Sieweke, M.H. and Wagner, D. and Dierks, C. and Haaf, T. and Ness, T. and Zaiss, M.M. and Voll, R.E. and Deshmukh, S.D. and Prinz, M. and Goldmann, T. and Hölscher, C. and Hauser, A.E. and Lopez-Contreras, A.J. and Grün, D. and Gorgoulis, V. and Diefenbach, A. and Henneke, P. and Triantafyllopoulou, A.
Cell 167 (5): 1264-1280. 17 November 2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P. and Nordström, K. and Gasparoni, G. and Salhab, A. and Kressler, C. and de Almeida, M. and Bassler, K. and Ulas, T. and Schmidt, F. and Xiong, J. and Glažar, P. and Klironomos, F. and Sinha, A. and Kinkley, S. and Yang, X. and Arrigoni, L. and Amirabad, A.. and Ardakani, F.B. and Feuerbach, L. and Gorka, O. and Ebert, P. and Müller, F. and Li, N. and Frischbutter, S. and Schlickeiser, S. and Cendon, C. and Fröhler, S. and Felder, B. and Gasparoni, N. and Imbusch, C.D. and Hutter, B. and Zipprich, G. and Tauchmann, Y. and Reinke, S. and Wassilew, G. and Hoffmann, U. and Richter, A.S. and Sieverling, L. and Chang, H.D. and Syrbe, U. and Kalus, U. and Eils, J. and Brors, B. and Manke, T. and Ruland, J. and Lengauer, T. and Rajewsky, N. and Chen, W. and Dong, J. and Sawitzki, B. and Chung, H.R. and Rosenstiel, P. and Schulz, M.H. and Schultze, J.L. and Radbruch, A. and Walter, J. and Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M. and Saydaminova, K. and Yumul, R. and Krishnan, R. and Liu, J. and Nagy, E.E. and Singh, M. and Izsvák, Z. and Cattaneo, R. and Uckert, W. and Palmer, D. and Ng, P. and Haworth, K.G. and Kiem, H.P. and Ehrhardt, A. and Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch.
Kaplan, O.I. and Berber, B. and Hekim, N. and Doluca, O.
Nucleic Acids Research 44 (19): 9083-9095. 2 November 2016

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
Noel, J.K. and Whitford, P.C.
Nature Communications 7 : 13314. 31 October 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E. and Sin, C. and Zauber, H. and Wells, J.N. and Donnelly, N. and Wang, X. and Hou, J. and Chen, W. and Storchova, Z. and Marsh, J.A. and Valleriani, A. and Selbach, M.
Cell 167 (3): 803-815. 20 October 2016

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
Textor, A. and Schmidt, K. and Kloetzel, P.M. and Weißbrich, B. and Perez, C. and Charo, J. and Anders, K. and Sidney, J. and Sette, A. and Schumacher, T.N.M. and Keller, C. and Busch, D.H. and Seifert, U. and Blankenstein, T.
Journal of Experimental Medicine 213 (11): 2333-2348. 17 October 2016

Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice.
Viola, J.R. and Lemnitzer, P. and Jansen, Y. and Csaba, G. and Winter, C. and Neideck, C. and Silvestre-Roig, C. and Dittmar, G. and Doering, Y. and Drechsler, M. and Weber, C. and Zimmer, R. and Cenac, N. and Soehnlein, O.
Circulation Research 119 (9): 1030-1038. 14 October 2016

Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke, M. and Ibrahim, D.M. and Andrey, G. and Schwarzer, W. and Heinrich, V. and Schoepflin, R. and Kraft, K. and Kempfer, R. and Jerkovic, I. and Chan, W.L. and Spielmann, M. and Timmermann, B. and Wittler, L. and Kurth, I. and Cambiaso, P. and Zuffardi, O. and Houge, G. and Lambie, L. and Brancati, F. and Pombo, A. and Vingron, M. and Spitz, F. and Mundlos, S.
Nature 538 (7624): 265-269. 13 October 2016

Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R. and Fast, E.M. and Solaimani, P. and Knezevic, K. and Eliades, A. and Patel, R. and Thambyrajah, R. and Unnikrishnan, A. and Thoms, J. and Beck, D. and Vink, C.S. and Smith, A. and Wong, J. and Shepherd, M. and Kent, D. and Roychoudhuri, R. and Paul, F. and Klippert, J. and Hammes, A. and Willnow, T. and Göttgens, B. and Dzierzak, E. and Zon, L.I. and Lacaud, G. and Kouskoff, V. and Pimanda, J.E.
Blood 128 (15): 1928-1939. 13 October 2016

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
Ferone, G. and Song, J.Y. and Sutherland, K.D. and Bhaskaran, R. and Monkhorst, K. and Lambooij, J.P. and Proost, N. and Gargiulo, G. and Berns, A.
Cancer Cell 30 (4): 519-532. 10 October 2016

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
Kandalla, P.K. and Sarrazin, S. and Molawi, K. and Berruyer, C. and Redelberger, D. and Favel, A. and Bordi, C. and de Bentzmann, S. and Sieweke, M.H.
Journal of Experimental Medicine 213 (11): 2269-2279. 10 October 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Mueller, R. and Heinemann, U. and Kaupp, M. and Wahl, M. and Risse, T.
Journal of the American Chemical Society 138 (39): 12868-12875. 5 October 2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S. and Kohl, T. and Williams, G.S.B. and Gusev, K. and Wagner, E. and Rog-Zielinska, E.A. and Hebisch, E. and Dura, M. and Didié, M. and Gotthardt, M. and Nikolaev, V.O. and Hasenfuss, G. and Kohl, P. and Ward, C.W. and Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye, J. and Wenke, N.K. and Chayka, M. and Leubner, J. and Murugan, R. and Maier, N. and Jurek, B. and Ly, L.T. and Brandl, D. and Rost, B.R. and Stumpf, A. and Schulz, P. and Radbruch, H. and Hauser, A.E. and Pache, F. and Meisel, A. and Harms, L. and Paul, F. and Dirnagl, U. and Garner, C. and Schmitz, D. and Wardemann, H. and Prüss, H.
Brain 139 (10): 2641-2652. 1 October 2016

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
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Gut 65 (10): 1690-1701. October 2016

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
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Nature Medicine 22 (10): 1140-1150. October 2016

Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
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Nature 537 (7622): 689-693. 29 September 2016

52 genetic loci influencing myocardial mass.
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Journal of the American College of Cardiology 68 (13): 1435-1448. 27 September 2016

Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
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Molecular Cell 63 (5): 827-839. 1 September 2016

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
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Nature Methods 13 (9): 741-748. September 2016

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.
Sarnowski, C. and Laprise, C. and Malerba, G. and Moffatt, M.F. and Dizier, M.H. and Morin, A. and Vincent, Q.B. and Rohde, K. and Esparza-Gordillo, J. and Margaritte-Jeannin, P. and Liang, L. and Lee, Y.A. and Bousquet, J. and Siroux, V. and Pignatti, P.F. and Cookson, W.O. and Lathrop, M. and Pastinen, T. and Demenais, F. and Bouzigon, E.
Journal of Allergy and Clinical Immunology 138 (3): 748-753. September 2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O. and Winter, D.R. and Giladi, A. and Vargas Aguilar, S. and Spinrad, A. and Sarrazin, S. and Ben-Yehuda, H. and David, E. and Zelada González, F. and Perrin, P. and Keren-Shaul, H. and Gury, M. and Lara-Astaiso, D. and Thaiss, C.A. and Cohen, M. and Bahar Halpern, K. and Baruch, K. and Deczkowska, A. and Lorenzo-Vivas, E. and Itzkovitz, S. and Elinav, E. and Sieweke, M.H. and Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
Simandi, Z. and Horvath, A. and Wright, L.C. and Cuaranta-Monroy, I. and De Luca, I. and Karolyi, K. and Sauer, S. and Deleuze, J.F. and Gudas, L.J. and Cowley, S.M. and Nagy, L.
Molecular Cell 63 (4): 647-661. 18 August 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S. and Helmuth, J. and Polansky, J.K. and Dunkel, I. and Gasparoni, G. and Froehler, S. and Chen, W. and Walter, J. and Hamann, A. and Chung, H.R.
Nature Communications 7 : 12514. 17 August 2016

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.
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Nature Cell Biology 18 (8): 864-875. August 2016

Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
Kang, Y. and Gohlke, U. and Engström, O. and Hamark, C. and Scheidt, T. and Kunstmann, S. and Heinemann, U. and Widmalm, G. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 138 (29): 9109-9118. 27 July 2016

Human gut microbes impact host serum metabolome and insulin sensitivity.
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Nature 535 (7612): 376-381. 21 July 2016

Glycolytic regulation of cell rearrangement in angiogenesis.
Cruys, B. and Wong, B.W. and Kuchnio, A. and Verdegem, D. and Cantelmo, A. R. and Conradi, L.C. and Vandekeere, S. and Bouché, A. and Cornelissen, I. and Vinckier, S. and Merks, R.M.H. and Dejana, E. and Gerhardt, H. and Dewerchin, M. and Bentley, K. and Carmeliet, P.
Nature Communications 7 : 12240. 20 July 2016

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Gödde, K. and Gschwend, O. and Puchkov, D. and Pfeffer, C.K. and Carleton, A. and Jentsch, T.J.
Nature Communications 7 : 12043. 8 July 2016

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.
Letunic, I. and Bork, P.
Nucleic Acids Research 44 (W1): W242-W245. 8 July 2016

Wars2 is a determinant of angiogenesis.
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Nature Communications 7 : 12061. 8 July 2016

The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway.
Hasler, D. and Lehmann, G. and Murakawa, Y. and Klironomos, F. and Jakob, L. and Grässer, F.A. and Rajewsky, N. and Landthaler, M. and Meister, G.
Molecular Cell 63 (1): 110-124. 7 July 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
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Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

The mRNA-bound proteome of the early fly embryo.
Wessels, H.H. and Imami, K. and Baltz, A.G. and Kolinksi, M. and Beldovskaya, A. and Selbach, M. and Small, S. and Ohler, U. and Landthaler, M.
Genome Research 26 (7): 1000-1009. July 2016

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
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Nature Communications 7 : 12039. 30 June 2016

CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L. and Haase, N. and Golic, M. and Rugor, J. and Solano, M.E. and Arck, P.C. and Gauster, M. and Huppertz, B. and Emontzpohl, C. and Stoppe, C. and Bernhagen, J. and Leng, L. and Bucala, R. and Schulz, H. and Heuser, A. and Weedon-Fekjær, S. and Johnsen, G.M. and Peetz, D. and Luft, F.C. and Staff, A.C. and Müller, D.N. and Dechend, R. and Herse, F.
Circulation Research 119 (1): 55-68. 24 June 2016

The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation.
von Delbrück, M. and Kniss, A. and Rogov, V.V. and Pluska, L. and Bagola, K. and Löhr, F. and Güntert, P. and Sommer, T. and Dötsch, V.
Molecular Cell 62 (6): 918-928. 16 June 2016

B cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B cell lymphoma in mice.
Knittel, G. and Liedgens, P. and Korovkina, D. and Seeger, J.M. and Al-Baldawi, Y. and Al-Maarri, M. and Fritz, C. and Vlantis, K. and Bezhanova, S. and Scheel, A.H. and Wolz, O.O. and Reimann, M. and Möller, P. and López, C. and Schlesner, M. and Lohneis, P. and Weber, A.N.R. and Trümper, L. and Staudt, L.M. and Ortmann, M. and Pasparakis, M. and Siebert, R. and Schmitt, C.A. and Klatt, A.R. and Wunderlich, F.T. and Schäfer, S.C. and Persigehl, T. and Montesinos-Rongen, M. and Odenthal, M. and Büttner, R. and Frenzel, L.P. and Kashkar, H. and Reinhardt, H.C.
Blood 127 (22): 2732-2741. 2 June 2016

Phase II trial of temsirolimus for relapsed/refractory primary CNS lymphoma.
Korfel, A. and Schlegel, U. and Herrlinger, U. and Dreyling, M. and Schmidt, C. and von Baumgarten, L. and Pezzutto, A. and Grobosch, T. and Kebir, S. and Thiel, E. and Martus, P. and Kiewe, P.
Journal of Clinical Oncology 34 (15): 1757-1763. 20 May 2016

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus.
Stempel, A.V. and Stumpf, A. and Zhang, H.Y. and Özdoğan, T. and Pannasch, U. and Theis, A.K. and Otte, D.M. and Wojtalla, A. and Racz, I. and Ponomarenko, A. and Xi, Z.X. and Zimmer, A. and Schmitz, D.
Neuron 90 (4): 795-809. 18 May 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. and Hilgenberg, E. and Stervbo, U. and Lampropoulou, V. and Shen, P. and Bunse, M. and Jaimes, Y. and Boudinot, P. and Radbruch, A. and Klemm, U. and Kühl, A.A. and Liblau, R. and Hoevelmeyer, N. and Anderton, S.M. and Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

Standardized benchmarking in the quest for orthologs.
Altenhoff, A.M. and Boeckmann, B. and Capella-Gutierrez, S. and Dalquen, D.A. and DeLuca, T. and Forslund, K. and Huerta-Cepas, J. and Linard, B. and Pereira, C. and Pryszcz, L.P. and Schreiber, F. and da Silva, A.S. and Szklarczyk, D. and Train, C.M. and Bork, P. and Lecompte, O. and von Mering, C. and Xenarios, I. and Sjölander, K. and Jensen, L.J. and Martin, M.J. and Muffato, M. and Gabaldón, T. and Lewis, S.E. and Thomas, P.D. and Sonnhammer, E. and Dessimoz, C.
Nature Methods 13 (5): 425-430. May 2016

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
Bartus, K. and Galino, J. and James, N.D. and Hernandez-Miranda, L.R. and Dawes, J.M. and Fricker, F.R. and Garratt, A.N. and McMahon, S.B. and Ramer, M.S. and Birchmeier, C. and Bennett, D.L.H. and Bradbury, E.J.
Brain 139 (Pt 5): 1394-1416. May 2016

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li, S.S. and Zhu, A. and Benes, V. and Costea, P.I. and Hercog, R. and Hildebrand, F. and Huerta-Cepas, J. and Nieuwdorp, M. and Salojaervi, J. and Voigt, A.Y. and Zeller, G. and Sunagawa, S. and de Vos, W.M. and Bork, P.
Science 352 (6285): 586-589. 29 April 2016

Plankton networks driving carbon export in the oligotrophic ocean.
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Nature 532 (7600): 465-470. 28 April 2016

Energy efficiency trade-offs drive nucleotide usage in transcribed regions.
Chen, W.H. and Lu, G. and Bork, P. and Hu, S. and Lercher, M.J.
Nature Communications 7 : 11334. 21 April 2016

4D visualization of replication foci in mammalian cells corresponding to individual replicons.
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Nature Communications 7 : 11231. 7 April 2016

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Gebala, V. and Collins, R. and Geudens, I. and Phng, L.K. and Gerhardt, H.
Nature Cell Biology 18 (4): 443-450. April 2016

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
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Nature Communications 7 : 11126. 30 March 2016

Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton.
Cornejo-Castillo, F.M. and Cabello, A.M. and Salazar, G. and Sanchez-Baracaldo, P. and Lima-Mendez, G. and Hingamp, P. and Alberti, A. and Sunagawa, S. and Bork, P. and de Vargas, C. and Raes, J. and Bowler, C. and Wincker, P. and Zehr, J.P. and Gasol, J.M. and Massana, R. and Acinas, S.G.
Nature Communications 7 : 11071. 22 March 2016

Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori, A. and Iskar, M. and Buczak, K. and Kastritis, P. and Parca, L. and Andres-Pons, A. and Singer, S. and Bork, P. and Beck, M.
Genome Biology 17 (1): 47. 14 March 2016

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I. and Messing, S.A. and Thomas, J. and Cosby, R.L. and Bilic, I. and Miskey, C. and Gogol-Döring, A. and Kapitonov, V. and Diem, T. and Dalda, A. and Jurka, J. and Pritham, E.J. and Dyda, F. and Izsvák, Z. and Ivics, Z.
Nature Communications 7 : 10716. 2 March 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. and Kammertoens, T. and Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

Integration of multi-omics data of a genome-reduced bacterium: prevalence of post-transcriptional regulation and its correlation with protein abundances.
Chen, W.H. and van Noort, V. and Lluch-Senar, M. and Hennrich, M.L. and Wodke, J.A.H. and Yus, E. and Alibes, A. and Roma, G. and Mende, D.R. and Pesavento, C. and Typas, A. and Gavin, A.C. and Serrano, L. and Bork, P.
Nucleic Acids Research 44 (3): 1192-1202. 18 February 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L. and Weng, Z. and Geirsdóttir, L. and Molawi, K. and Maurizio, J. and Fenouil, R. and Mossadegh-Keller, N. and Gimenez, G. and VanHille, L. and Beniazza, M. and Favret, J. and Berruyer, C. and Perrin, P. and Hacohen, N. and Andrau, J.C. and Ferrier, P. and Dubreuil, P. and Sidow, A. and Sieweke, M.H.
Science 351 (6274): aad5510. 12 February 2016

miR-23~27~24 clusters control effector T cell differentiation and function.
Cho, S. and Wu, C.J. and Yasuda, T. and Cruz, L.O. and Khan, A.A. and Lin, L.L. and Nguyen, D.T. and Miller, M. and Lee, H.M. and Kuo, M.L. and Broide, D.H. and Rajewsky, K. and Rudensky, A.Y. and Lu, L.F.
Journal of Experimental Medicine 213 (2): 235-249. 8 February 2016

Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
Grandin, M. and Meier, M. and Delcros, J.G. and Nikodemus, D. and Reuten, R. and Patel, T.R. and Goldschneider, D. and Orriss, G. and Krahn, N. and Boussouar, A. and Abes, R. and Dean, Y. and Neves, D. and Bernet, A. and Depil, S. and Schneiders, F. and Poole, K. and Dante, R. and Koch, M. and Mehlen, P. and Stetefeld, J.
Cancer Cell 29 (2): 173-185. 8 February 2016

Genome-wide polyadenylation maps reveal dynamic mRNA 3'-end formation in the failing human heart.
Creemers, E.E. and Bawazeer, A. and Ugalde, A.P. and van Deutekom, H.W.M. and van der Made, I. and de Groot, N.E. and Adriaens, M.E. and Cook, S.A. and Bezzina, C.R. and Hubner, N. and van der Velden, J. and Elkon, R. and Agami, R. and Pinto, Y.M.
Circulation Research 118 (3): 433-438. 5 February 2016

Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L. and Mukherjee, N. and Wyler, E. and Zauber, H. and Hirsekorn, A. and Selbach, M. and Landthaler, M. and Obermayer, B. and Ohler, U.
Nature Methods 13 (2): 165-170. February 2016

Immunological memory: lessons from the past and a look to the future.
Farber, D.L. and Netea, M.G. and Radbruch, A. and Rajewsky, K. and Zinkernagel, R.M.
Nature Reviews Immunology 16 (2): 124-128. February 2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. and Singh, M. and Sun, C. and Besser, D. and Prigione, A. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature Protocols 11 (2): 327-346. February 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K. and Happel, K. and Eelen, G. and Schoors, S. and Oellerich, M.F. and Lim, R. and Zimmermann, B. and Aspalter, I.M. and Franco, C.A. and Boettger, T. and Braun, T. and Fruttiger, M. and Rajewsky, K. and Keller, C. and Brüning, J.C. and Gerhardt, H. and Carmeliet, P. and Potente, M.
Nature 529 (7585): 216-220. 14 January 2016

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S. and Fuchs, N.V. and Upton, K.R. and Muñoz-Lopez, M. and Shukla, R. and Wang, J. and Garcia-Cañadas, M. and Lopez-Ruiz, C. and Gerhardt, D.J. and Sebe, A. and Grabundzija, I. and Merkert, S. and Gerdes, P. and Pulgarin, J.A. and Bock, A. and Held, U. and Witthuhn, A. and Haase, A. and Sarkadi, B. and Löwer, J. and Wolvetang, E.J. and Martin, U. and Ivics, Z. and Izsvák, Z. and Garcia-Perez, J.L. and Faulkner, G.J. and Schumann, G.G.
Nature Communications 7 : 10286. 8 January 2016

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Huerta-Cepas, J. and Szklarczyk, D. and Forslund, K. and Cook, H. and Heller, D. and Walter, M.C. and Rattei, T. and Mende, D.R. and Sunagawa, S. and Kuhn, M. and Jensen, L.J. and von Mering, C. and Bork, P.
Nucleic Acids Research 44 (D1): D286-D293. 4 January 2016

The SIDER database of drugs and side effects.
Kuhn, M. and Letunic, I. and Jensen, L.J. and Bork, P.
Nucleic Acids Research 44 (D1): D1075-D1079. 4 January 2016

STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.
Szklarczyk, D. and Santos, A. and von Mering, C. and Jensen, L.J. and Bork, P. and Kuhn, M.
Nucleic Acids Research 44 (D1): D380-D384. 4 January 2016

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H. and Haas, S.A. and Chelly, J. and Van Esch, H. and Raynaud, M. and de Brouwer, A.P.M. and Weinert, S. and Froyen, G. and Frints, S.G.M. and Laumonnier, F. and Zemojtel, T. and Love, M.I. and Richard, H. and Emde, A.K. and Bienek, M. and Jensen, C. and Hambrock, M. and Fischer, U. and Langnick, C. and Feldkamp, M. and Wissink-Lindhout, W. and Lebrun, N. and Castelnau, L. and Rucci, J. and Montjean, R. and Dorseuil, O. and Billuart, P. and Stuhlmann, T. and Shaw, M. and Corbett, M.A. and Gardner, A. and Willis-Owen, S. and Tan, C. and Friend, K.L. and Belet, S. and van Roozendaal, K.E.P. and Jimenez-Pocquet, M. and Moizard, M.P. and Ronce, N. and Sun, R. and O'Keeffe, S. and Chenna, R. and van Bömmel, A. and Goeke, J. and Hackett, A. and Field, M. and Christie, L. and Boyle, J. and Haan, E. and Nelson, J. and Turner, G. and Baynam, G. and Gillessen-Kaesbach, G. and Mueller, U. and Steinberger, D. and Budny, B. and Badura-Stronka, M. and Latos-Bieleńska, A. and Ousager, L.B. and Wieacker, P. and Rodríguez Criado, G. and Bondeson, M.L. and Annerén, G. and Dufke, A. and Cohen, M. and Van Maldergem, L. and Vincent-Delorme, C. and Echenne, B. and Simon-Bouy, B. and Kleefstra, T. and Willemsen, M. and Fryns, J.P. and Devriendt, K. and Ullmann, R. and Vingron, M. and Wrogemann, K. and Wienker, T.F. and Tzschach, A. and van Bokhoven, H. and Gecz, J. and Jentsch, T.J. and Chen, W. and Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21 (1): 133-148. January 2016

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
Schmitt, J. and Schwarz, K. and Baurecht, H. and Hotze, M. and Fölster-Holst, R. and Rodríguez, E. and Lee, Y.A.E. and Franke, A. and Degenhardt, F. and Lieb, W. and Gieger, C. and Kabesch, M. and Nöthen, M.M. and Irvine, A.D. and McLean, W.H.I. and Deckert, S. and Stephan, V. and Schwarz, P. and Aringer, M. and Novak, N. and Weidinger, S.
Journal of Allergy and Clinical Immunology 137 (1): 130-136. January 2016

The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
Silva, C.R. and Oliveira, S.M. and Hoffmeister, C. and Funck, V. and Guerra, G.P. and Trevisan, G. and Tonello, R. and Rossato, M.F. and Pesquero, J.B. and Bader, M. and Oliveira, M.S. and McDougall, J.J. and Ferreira, J.
Annals of the Rheumatic Diseases 75 (1): 260-268. January 2016

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.
Fraser, J. and Ferrai, C. and Chiariello, A.M. and Schueler, M. and Rito, T. and Laudanno, G. and Barbieri, M. and Moore, B.L. and Kraemer, D.C.A. and Aitken, S. and Xie, S.Q. and Morris, K.J. and Itoh, M. and Kawaji, H. and Jaeger, I. and Hayashizaki, Y. and Carninci, P. and Forrest, A.R.R. and Semple, C.A. and Dostie, J. and Pombo, A. and Nicodemi, M.
Molecular Systems Biology 11 (12): 852. 23 December 2015

PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S. and Chu, V.T. and Yasuda, T. and Franklin, A. and Graf, R. and Calado, D.P. and Li, S. and Imami, K. and Selbach, M. and Di Virgilio, M. and Bullinger, L. and Rajewsky, K.
Immunity 43 (6): 1075-1086. 15 December 2015

A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer.
von Eyss, B. and Jaenicke, L.A. and Kortlever, R.M. and Royla, N. and Wiese, K.E. and Letschert, S. and McDuffus, L.A. and Sauer, M. and Rosenwald, A. and Evan, G.I. and Kempa, S. and Eilers, M.
Cancer Cell 28 (6): 743-757. 14 December 2015

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K. and Hildebrandt, F. and Nielsen, T. and Falony, G. and Le Chatelier, E. and Sunagawa, S. and Prifti, E. and Vieira-Silva, S. and Gudmundsdottir, V. and Pedersen, H.K. and Arumugam, M. and Kristiansen, K. and Voigt, A.Y. and Vestergaard, H. and Hercog, R. and Costea, P.I. and Kultima, J.R. and Li, J. and Jørgensen, T. and Levenez, F. and Dore, J. and Nielsen, H.B. and Brunak, S. and Raes, J. and Hansen, T. and Wang, J. and Ehrlich, S.D. and Bork, P. and Pedersen, O.
Nature 528 (7581): 262-266. 10 December 2015

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Finkin, S. and Yuan, D. and Stein, I. and Taniguchi, K. and Weber, A. and Unger, K. and Browning, J.L. and Goossens, N. and Nakagawa, S. and Gunasekaran, G. and Schwartz, M.E. and Kobayashi, M. and Kumada, H. and Berger, M. and Pappo, O. and Rajewsky, K. and Hoshida, Y. and Karin, M. and Heikenwalder, M. and Ben-Neriah, Y. and Pikarsky, E.
Nature Immunology 16 (12): 1235-1244. December 2015

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster, L. and Standl, M. and Waage, J. and Baurecht, H. and Hotze, M. and Strachan, D.P. and Curtin, J.A. and Bønnelykke, K. and Tian, C. and Takahashi, A. and Esparza-Gordillo, J. and Alves, A.C. and Thyssen, J.P. and den Dekker, H.T. and Ferreira, M.A. and Altmaier, E. and Sleiman, P.M.A. and Xiao, F.L. and Gonzalez, J.R. and Marenholz, I. and Kalb, B. and Pino-Yanes, M. and Xu, C.J. and Carstensen, L. and Groen-Blokhuis, M.M. and Venturini, C. and Pennell, C.E. and Barton, S.J. and Levin, A.M. and Curjuric, I. and Bustamante, M. and Kreiner-Møller, E. and Lockett, G.A. and Bacelis, J. and Bunyavanich, S. and Myers, R.A. and Matanovic, A. and Kumar, A. and Tung, J.Y. and Hirota, T. and Kubo, M. and McArdle, W.L. and Henderson, A.J. and Kemp, J.P. and Zheng, J. and Smith, G.D. and Rüschendorf, F. and Bauerfeind, A. and Lee-Kirsch, M.A. and Arnold, A. and Homuth, G. and Schmidt, C.O. and Mangold, E. and Cichon, S. and Keil, T. and Rodríguez, E. and Peters, A. and Franke, A. and Lieb, W. and Novak, N. and Fölster-Holst, R. and Horikoshi, M. and Pekkanen, J. and Sebert, S. and Husemoen, L.L. and Grarup, N. and de Jongste, J.C. and Rivadeneira, F. and Hofman, A. and Jaddoe, V.W.V. and Pasmans, S.G.M.A. and Elbert, N.J. and Uitterlinden, A.G. and Marks, G.B. and Thompson, P.J. and Matheson, M.C. and Robertson, C.F. and Ried, J.S. and Li, J. and Zuo, X.B. and Zheng, X.D. and Yin, X.Y. and Sun, L.D. and McAleer, M.A. and O'Regan, G.M. and Fahy, C.M.R. and Campbell, L.E. and Macek, M. and Kurek, M. and Hu, D. and Eng, C. and Postma, D.S. and Feenstra, B. and Geller, F. and Hottenga, J.J. and Middeldorp, C.M. and Hysi, P. and Bataille, V. and Spector, T. and Tiesler, C.M.T. and Thiering, E. and Pahukasahasram, B. and Yang, J.J. and Imboden, M. and Huntsman, S. and Vilor-Tejedor, N. and Relton, C.L. and Myhre, R. and Nystad, W. and Custovic, A. and Weiss, S.T. and Meyers, D.A. and Söderhäll, C. and Melén, E. and Ober, C. and Raby, B.A. and Simpson, A. and Jacobsson, B. and Holloway, J.W. and Bisgaard, H. and Sunyer, J. and Probst-Hensch, N.M. and Williams, L.K. and Godfrey, K.M. and Wang, C.A. and Boomsma, D.I. and Melbye, M. and Koppelman, G.H. and Jarvis, D. and McLean, W.H.I. and Irvine, A.D. and Zhang, X.J. and Hakonarson, H. and Gieger, C. and Burchard, E.G. and Martin, N.G. and Duijts, L. and Linneberg, A. and Jarvelin, M.R. and Noethen, M.M. and Lau, S. and Hübner, N. and Lee, Y.A. and Tamari, M. and Hinds, D.A. and Glass, D. and Brown, S.J. and Heinrich, J. and Evans, D.M. and Weidinger, S.
Nature Genetics 47 (12): 1449-1456. December 2015

Optogenetic acidification of synaptic vesicles and lysosomes.
Rost, B.R. and Schneider, F. and Grauel, M.K. and Wozny, C. and Bentz, C.G. and Blessing, A. and Rosenmund, T. and Jentsch, T.J. and Schmitz, D. and Hegemann, P. and Rosenmund, C.
Nature Neuroscience 18 (12): 1845-1852. December 2015

Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I. and Esparza-Gordillo, J. and Rüschendorf, F. and Bauerfeind, A. and Strachan, D.P. and Spycher, B.D. and Baurecht, H. and Margaritte-Jeannin, P. and Sääf, A. and Kerkhof, M. and Ege, M. and Baltic, S. and Matheson, M.C. and Li, J. and Michel, S. and Ang, W.Q. and McArdle, W. and Arnold, A. and Homuth, G. and Demenais, F. and Bouzigon, E. and Söderhäll, C. and Pershagen, G. and de Jongste, J.C. and Postma, D.S. and Braun-Fahrlaender, C. and Horak, E. and Ogorodova, L.M. and Puzyrev, V.P. and Bragina, E.Y. and Hudson, T.J. and Morin, C. and Duffy, D.L. and Marks, G.B. and Robertson, C.F. and Montgomery, G.W. and Musk, B. and Thompson, P.J. and Martin, N.G. and James, A. and Sleiman, P. and Toskala, E. and Rodriguez, E. and Fölster-Holst, R. and Franke, A. and Lieb, W. and Gieger, C. and Heinzmann, A. and Rietschel, E. and Keil, T. and Cichon, S. and Nöthen, M.M. and Pennell, C.E. and Sly, P.D. and Schmidt, C.O. and Matanovic, A. and Schneider, V. and Heinig, M. and Hübner, N. and Holt, P.G. and Lau, S. and Kabesch, M. and Weidinger, S. and Hakonarson, H. and Ferreira, M.A.R. and Laprise, C. and Freidin, M.B. and Genuneit, J. and Koppelman, G.H. and Melén, E. and Dizier, M.H. and Henderson, A.J. and Lee, Y.A.
Nature Communications 6 : 8804. 6 November 2015

Operon structure and cotranslational subunit association direct protein assembly in bacteria.
Shieh, Y.W. and Minguez, P. and Bork, P. and Auburger, J.J. and Guilbride, D.L. and Kramer, G. and Bukau, B.
Science 350 (6261): 678-680. 6 November 2015

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J. and Gebhardt, M. and Heinig, M. and Rintisch, C. and Schroeder, A. and Neuhofer, W. and Hilgers, K. and Manzel, A. and Schwartz, C. and Kleinewietfeld, M. and Voelkl, J. and Schatz, V. and Linker, R.A. and Lang, F. and Voehringer, D. and Wright, M.D. and Hubner, N. and Dechend, R. and Jantsch, J. and Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125 (11): 4223-4238. 2 November 2015

Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N. and Jae, N. and Heumueller, A.W. and Chen, W. and Boon, R.A. and Stellos, K. and Zeiher, A.M. and John, D. and Uchida, S. and Dimmeler, S.
Circulation Research 117 (10): 884-890. 23 October 2015

Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A. and Sozzani, R. and Yardımcı, G.G. and Petricka, J.J. and Vernoux, T. and Blilou, I. and Alonso, J. and Winter, C.M. and Ohler, U. and Scheres, B. and Benfey, P.N.
Science 350 (6259): 426-430. 23 October 2015

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A. and Jörg, S. and Duscha, A. and Berg, J. and Manzel, A. and Waschbisch, A. and Hammer, A. and Lee, D.H. and May, C. and Wilck, N. and Balogh, A. and Ostermann, A.I. and Schebb, N.H. and Akkad, D.A. and Grohme, D.A. and Kleinewietfeld, M. and Kempa, S. and Thöne, J. and Demir, S. and Müller, D.N. and Gold, R. and Linker, R.A.
Immunity 43 (4): 817-829. 20 October 2015

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.
Feutlinske, F. and Browarski, M. and Ku, M.C. and Trnka, P. and Waiczies, S. and Niendorf, T. and Stallcup, W.B. and Glass, R. and Krause, E. and Maritzen, T.
Nature Communications 6 : 8535. 5 October 2015

T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice.
Dargel, C. and Bassani-Sternberg, M. and Hasreiter, J. and Zani, F. and Bockmann, J.H. and Thiele, F. and Bohne, F. and Wisskirchen, K. and Wilde, S. and Sprinzl, M.F. and Schendel, D.J. and Krackhardt, A.M. and Uckert, W. and Wohlleber, D. and Schiemann, M. and Stemmer, K. and Heikenwälder, M. and Busch, D.H. and Richter, G. and Mann, M. and Protzer, U.
Gastroenterology 149 (4): 1042-1052. October 2015

Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years.
Grabenhenrich, L.B. and Keil, T. and Reich, A. and Gough, H. and Beschorner, J. and Hoffmann, U. and Bauer, C.P. and Forster, J. and Schuster, A. and Schramm, D. and Nitsche, O. and Zepp, F. and Lee, Y.A. and Bergmann, R. and Bergmann, K. and Wahn, U. and Lau, S.
Journal of Allergy and Clinical Immunology 136 (4): 932-940. October 2015

Crystal structure of the dynamin tetramer.
Reubold, T.F. and Faelber, K. and Plattner, N. and Posor, Y. and Ketel, K. and Curth, U. and Schlegel, J. and Anand, R. and Manstein, D.J. and Noé, F. and Haucke, V. and Daumke, O. and Eschenburg, S.
Nature 525 (7569): 404-408. 17 September 2015

Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D. and Zauber, H. and Bielow, C. and Thiel, D. and Kutz, K. and Calviello, L. and Mastrobuoni, G. and Rajewsky, N. and Kempa, S. and Selbach, M. and Obermayer, B.
Genome Biology 16 : 179. 14 September 2015

Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in klatskin tumor patients.
Lederer, A. and Herrmann, P. and Seehofer, D. and Dietel, M. and Pratschke, J. and Schlag, P. and Stein, U.
Hepatology 62 (3): 841-850. September 2015

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T. and Chopra, A. and Nafissi, N. and Polacheck, W.J. and Benson, C.C. and Swist, S. and Gorham, J. and Yang, L. and Schafer, S. and Sheng, C.C. and Haghighi, A. and Homsy, J. and Hubner, N. and Church, G. and Cook, S.A. and Linke, W.A. and Chen, C.S. and Seidman, J.G. and Seidman, C.E.
Science 349 (6251): 982-986. 28 August 2015

Extensive allele-specific translational regulation in hybrid mice.
Hou, J. and Wang, X. and McShane, E. and Zauber, H. and Sun, W. and Selbach, M. and Chen, W.
Molecular Systems Biology 11 (8): 825. 7 August 2015

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C. and Rosser, J.M. and Newkirk, S.J. and Yin, J. and Jiang, X. and Xing, Z. and Whitmore, L. and Bashir, S. and Ivics, Z. and Izsvák, Z. and Ye, P. and Yu, Y.E. and An, W.
Genome Research 25 (8): 1135-1146. August 2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H. and Chivite, I. and Angulo-Urarte, A. and Soler, A. and Sutherland, J.D. and Arruabarrena-Aristorena, A. and Ragab, A. and Lim, R. and Malumbres, M. and Fruttiger, M. and Potente, M. and Serrano, M. and Fabra, A. and Vinals, F. and Casanovas, O. and Pandolfi, P.P. and Bigas, A. and Carracedo, A. and Gerhardt, H. and Graupera, M.
Nature Communications 6 : 7935. 31 July 2015

New role for the (pro)renin receptor in T cell development.
Geisberger, S. and Maschke, U. and Gebhardt, M. and Kleinewietfeld, M. and Manzel, A. and Linker, R.A. and Chidgey, A. and Dechend, R. and Nguyen, G. and Daumke, O. and Muller, D.N. and Wright, M.D. and Binger, K.J.
Blood 126 (4): 504-507. 23 July 2015

Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c.
Wiegreffe, C. and Simon, R. and Peschkes, K. and Kling, C. and Strehle, M. and Cheng, J. and Srivatsa, S. and Liu, P. and Jenkins, N.A. and Copeland, N.G. and Tarabykin, V. and Britsch, S.
Neuron 87 (2): 311-325. 15 July 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML-Study IV.
Saussele, S. and Krauss, M.P. and Hehlmann, R. and Lauseker, M. and Proetel, U. and Kalmanti, L. and Hanfstein, B. and Fabarius, A. and Kraemer, D. and Berdel, W.E. and Bentz, M. and Staib, P. and de Wit, M. and Wernli, M. and Zettl, F. and Hebart, H.F. and Hahn, M. and Heymanns, J. and Schmidt-Wolf, I. and Schmitz, N. and Eckart, M.J. and Gassmann, W. and Bartholomaeus, A. and Pezzutto, A. and Oppliger Leibundgut, E. and Heim, D. and Krause, S.W. and Burchert, A. and Hofmann, W.K. and Hasford, J. and Hochhaus, A. and Pfirrmann, M. and Müller, M.C.
Blood 126 (1): 42-49. 2 July 2015

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao, Q. and Sun, W. and Ballegeer, M. and Libert, C. and Chen, W.
Molecular Systems Biology 11 (7): 816. 1 July 2015

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E. and Iwata, A. and Albring, J. and Wu, X. and Tussiwand, R. and Kc, W. and Kretzer, N.M. and Briseno, C.G. and Durai, V. and Bagadia, P. and Haldar, M. and Schoenheit, J. and Rosenbauer, F. and Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes.
Pfeifer, M. and Zheng, B. and Erdmann, T. and Koeppen, H. and McCord, R. and Grau, M. and Staiger, A. and Chai, A. and Sandmann, T. and Madle, H. and Doerken, B. and Chu, Y.W. and Chen, A.I. and Lebovic, D. and Salles, G.A. and Czuczman, M.S. and Palanca-Wessels, M.C. and Press, O.W. and Advani, R. and Morschhauser, F. and Cheson, B.D. and Lenz, P. and Ott, G. and Polson, A.G. and Mundt, K.E. and Lenz, G.
Leukemia 29 (7): 1578-1586. July 2015

Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial.
Pelzer, U. and Opitz, B. and Deutschinoff, G. and Stauch, M. and Reitzig, P.C. and Hahnfeld, S. and Mueller, L. and Grunewald, M. and Stieler, J.M. and Sinn, M. and Denecke, T. and Bischoff, S. and Oettle, H. and Doerken, B. and Riess, H.
Journal of Clinical Oncology 33 (18): 2028-2034. 20 June 2015

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Aspalter, I.M. and Gordon, E. and Dubrac, A. and Ragab, A. and Narloch, J. and Vizán, P. and Geudens, I. and Collins, R.T. and Franco, C.A. and Abrahams, C.L. and Thurston, G. and Fruttiger, M. and Rosewell, I. and Eichmann, A. and Gerhardt, H.
Nature Communications 6 : 7264. 17 June 2015

Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed.
Rybak-Wolf, A. and Stottmeister, C. and Glažar, P. and Jens, M. and Pino, N. and Giusti, S. and Hanan, M. and Behm, M. and Bartok, O. and Ashwal-Fluss, R. and Herzog, M. and Schreyer, L. and Papavasileiou, P. and Ivanov, A. and Öhman, M. and Refojo, D. and Kadener, S. and Rajewsky, N.
Molecular Cell 58 (5): 870-885. 4 June 2015

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
Lim, H.W. and Uhlenhaut, N.H. and Rauch, A. and Weiner, J. and Hübner, S. and Hübner, N. and Won, K.J. and Lazar, M.A. and Tuckermann, J. and Steger, D.J.
Genome Research 25 (6): 836-844. June 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G. and Aydin, A. and Luft, F.C. and Schächterle, C. and Weise, A. and Stricker, S. and Lindschau, C. and Vaegler, M. and Qadri, F. and Toka, H.R. and Schulz, H. and Krawitz, P.M. and Parkhomchuk, D. and Hecht, J. and Hollfinger, I. and Wefeld-Neuenfeld, Y. and Bartels-Klein, E. and Mühl, A. and Kann, M. and Schuster, H. and Chitayat, D. and Bialer, M.G. and Wienker, T.F. and Ott, J. and Rittscher, K. and Liehr, T. and Jordan, J. and Plessis, G. and Tank, J. and Mai, K. and Naraghi, R. and Hodge, R. and Hopp, M. and Hattenbach, L.O. and Busjahn, A. and Rauch, A. and Vandeput, F. and Gong, M. and Rüschendorf, F. and Hübner, N. and Haller, H. and Mundlos, S. and Bilginturan, N. and Movsesian, M.A. and Klussmann, E. and Toka, O. and Bähring, S.
Nature Genetics 47 (6): 647-653. June 2015

A multiplexed NMR-reporter approach to measure cellular kinase and phosphatase activities in real-time.
Thongwichian, R. and Kosten, J. and Benary, U. and Rose, H.M. and Stuiver, M. and Theillet, F.X. and Dose, A. and Koch, B. and Yokoyama, H. and Schwarzer, D. and Wolf, J. and Selenko, P.
Journal of the American Chemical Society 137 (20): 6468-6471. 27 May 2015

Translational regulation shapes the molecular landscape of complex disease phenotypes.
Schafer, S. and Adami, E. and Heinig, M. and Costa Rodrigues, K.E. and Kreuchwig, F. and Silhavy, J. and van Heesch, S. and Simaite, D. and Rajewsky, N. and Cuppen, E. and Pravenec, M. and Vingron, M. and Cook, S.A. and Hubner, N.
Nature Communications 6 : 7200. 26 May 2015

Patterns and ecological drivers of ocean viral communities.
Brum, J.R. and Ignacio-Espinoza, J.C. and Roux, S. and Doulcier, G. and Acinas, S.G. and Alberti, A. and Chaffron, S. and Cruaud, C. and de Vargas, C. and Gasol, J.M. and Gorsky, G. and Gregory, A.C. and Guidi, L. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Poulos, B.T. and Schwenck, S.M. and Speich, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Bork, P. and Bowler, C. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Sullivan, M.B.
Science 348 (6237): 1261498. 22 May 2015

Determinants of community structure in the global plankton interactome.
Lima-Mendez, G. and Faust, K. and Henry, N. and Decelle, J. and Colin, S. and Carcillo, F. and Chaffron, S. and Ignacio-Espinosa, J.C. and Roux, S. and Vincent, F. and Bittner, L. and Darzi, Y. and Wang, J. and Audic, S. and Berline, L. and Bontempi, G. and Cabello, A.M. and Coppola, L. and Cornejo-Castillo, F.M. and d' Ovidio, F. and De Meester, L. and Ferrera, I. and Garet-Delmas, M.J. and Guidi, L. and Lara, E. and Pesant, S. and Royo-Llonch, M. and Salazar, G. and Sanchez, P. and Sebastian, M. and Souffreau, C. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Gorsky, G. and Not, F. and Ogata, H. and Speich, S. and Stemmann, L. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Sunagawa, S. and Bork, P. and Sullivan, M.B. and Karsenti, E. and Bowler, C. and de Vargas, C. and Raes, J.
Science 348 (6237): 1262073. 22 May 2015

Structure and function of the global ocean microbiome.
Sunagawa, S. and Coelho, L.P. and Chaffron, S. and Kultima, J.R. and Labadie, K. and Salazar, G. and Djahanschiri, B. and Zeller, G. and Mende, D.R. and Alberti, A. and Cornejo-Castillo, F.M. and Costea, P.I. and Cruaud, C. and d'Ovidio, F. and Engelen, S. and Ferrera, I. and Gasol, J.M. and Guidi, L. and Hildebrand, F. and Kokoszka, F. and Lepoivre, C. and Lima-Mendez, G. and Poulain, J. and Poulos, B.T. and Royo-Llonch, M. and Sarmento, H. and Vieira-Silva, S. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Bowler, C. and de Vargas, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Jaillon, O. and Not, F. and Ogata, H. and Pesant, S. and Speich, S. and Stemmann, L. and Sullivan, M.B. and Weissenbach, J. and Wincker, P. and Karsenti, E. and Raes, J. and Acinas, S.G. and Bork, P.
Science 348 (6237): 1261359. 22 May 2015

Environmental characteristics of Agulhas rings affect interocean plankton transport.
Villar, E. and Farrant, G.K. and Follows, M. and Garczarek, L. and Speich, S. and Audic, S. and Bittner, L. and Blanke, B. and Brum, J.R. and Brunet, C. and Casotti, R. and Chase, A. and Dolan, J.R. and d'Ortenzio, F. and Gattuso, J.P. and Grima, N. and Guidi, L. and Hill, C.N. and Jahn, O. and Jamet, J.L. and Le Goff, H. and Lepoivre, C. and Malviya, S. and Pelletier, E. and Romagnan, J.B. and Roux, S. and Santini, S. and Scalco, E. and Schwenck, S.M. and Tanaka, A. and Testor, P. and Vannier, T. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Boss, E. and de Vargas, C. and Gorsky, G. and Ogata, H. and Pesant, S. and Sullivan, M.B. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Bowler, C. and Not, F. and Hingamp, P. and Iudicone, D.
Science 348 (6237): 1261447. 22 May 2015

Eukaryotic plankton diversity in the sunlit ocean.
de Vargas, C. and Audic, S. and Henry, N. and Decelle, J. and Mahe, F. and Logares, R. and Lara, E. and Berney, C. and Le Bescot, N. and Probert, I. and Carmichael, M. and Poulain, J. and Romac, S. and Colin, S. and Aury, J.M. and Bittner, L. and Chaffron, S. and Dunthorn, M. and Engelen, S. and Flegontova, O. and Guidi, L. and Horak, A. and Jaillon, O. and Lima-Mendez, G. and Lukes, J. and Malviya, S. and Morard, R. and Mulot, M. and Scalco, E. and Siano, R. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Bowler, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Raes, J. and Sieracki, M.E. and Speich, S. and Stemmann, L. and Sunagawa, S. and Weissenbach, J. and Wincker, P. and Karsenti, E.
Science 348 (6237): 1261605. 22 May 2015

Photoswitchable fatty acids enable optical control of TRPV1.
Frank, J.A. and Moroni, M. and Moshourab, R. and Sumser, M. and Lewin, G.R. and Trauner, D.
Nature Communications 6 : 7118. 21 May 2015

Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.
Mino, T. and Murakawa, Y. and Fukao, A. and Vandenbon, A. and Wessels, H.H. and Ori, D. and Uehata, T. and Tartey, S. and Akira, S. and Suzuki, Y. and Vinuesa, C.G. and Ohler, U. and Standley, D.M. and Landthaler, M. and Fujiwara, T. and Takeuchi, O.
Cell 161 (5): 1058-1073. 21 May 2015

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Hoffmann, C.J. and Harms, U. and Rex, A. and Szulzewsky, F. and Wolf, S.A. and Grittner, U. and Lättig-Tünnemann, G. and Sendtner, M. and Kettenmann, H. and Dirnagl, U. and Endres, M. and Harms, C.
Circulation 131 (20): 1772-1782. 19 May 2015

eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.
Huang, J. and Chen, J. and Esparza, J. and Ding, J. and Elder, J.T. and Abecasis, G.R. and Lee, Y.A. and Lathrop, G.M. and Moffatt, M.F. and Cookson, W.O.C. and Liang, L.
Nature Communications 6 : 6821. 8 May 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. and Weber, T. and Wefers, B. and Wurst, W. and Sander, S. and Rajewsky, K. and Kühn, R.
Nature Biotechnology 33 (5): 543-548. May 2015

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M. and Bounab, Y. and Strempel, N. and Klockmeier, K. and Yigit, S. and Friedrich, R.P. and Chaurasia, G. and Li, S. and Hesse, F. and Riechers, S.P. and Russ, J. and Nicoletti, C. and Boeddrich, A. and Wiglenda, T. and Haenig, C. and Schnoegl, S. and Fournier, D. and Graham, R.K. and Hayden, M.R. and Sigrist, S. and Bates, G.P. and Priller, J. and Andrade-Navarro, M.A. and Futschik, M.E. and Wanker, E.E.
Genome Research 25 (5): 701-713. May 2015

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv, Y. and Shomer, I. and Cohen-Kaplan, V. and Snijder, B. and Superti-Furga, G. and Gonen, H. and Sommer, T. and Ziv, T. and Admon, A. and Naroditsky, I. and Jbara, M. and Brik, A. and Pikarsky, E. and Kwon, Y.T. and Doweck, I. and Ciechanover, A.
Cell 161 (2): 333-347. 9 April 2015

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S. and Bruning, U. and Missiaen, R. and Queiroz, K.C.S. and Borgers, G. and Elia, I. and Zecchin, A. and Cantelmo, A.R. and Christen, S. and Goveia, J. and Heggermont, W. and Goddé, L. and Vinckier, S. and Van Veldhoven, P.P. and Eelen, G. and Schoonjans, L. and Gerhardt, H. and Dewerchin, M. and Baes, M. and De Bock, K. and Ghesquière, B. and Lunt, S.Y. and Fendt, S.M. and Carmeliet, P.
Nature 520 (7546): 192-197. 9 April 2015

Temporal and technical variability of human gut metagenomes.
Voigt, A.Y. and Costea, P.I. and Kultima, J.R. and Li, S.S. and Zeller, G. and Sunagawa, S. and Bork, P.
Genome Biology 16 (1): 73. 8 April 2015

A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
Aleksandrova, K. and Chuang, S.C. and Boeing, H. and Zuo, H. and Tell, G.S. and Pischon, T. and Jenab, M. and Bueno-de-Mesquita, B. and Vollset, S.E. and Midttun, Ø. and Ueland, P.M. and Fedirko, V. and Johansson, M. and Weiderpass, E. and Severi, G. and Racine, A. and Boutron-Ruault, M.C. and Kaaks, R. and Kühn, T. and Tjønneland, A. and Overvad, K. and Quirós, J.R. and Jakszyn, P. and Sánchez, M.J. and Dorronsoro, M. and Chirlaque, M.D. and Ardanaz, E. and Khaw, K.T. and Wareham, N.J. and Travis, R.C. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Palli, D. and Sieri, S. and Tumino, R. and Panico, S. and May, A.M. and Palmqvist, R. and Ljuslinder, I. and Kong, S.Y.J. and Freisling, H. and Gunter, M.J. and Lu, Y. and Cross, A.J. and Riboli, E. and Vineis, P.
Journal of the National Cancer Institute 107 (4): djv010. April 2015

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito, H. and Shiwaku, H. and Yoshida, C. and Homma, H. and Luo, H. and Chen, X. and Fujita, K. and Musante, L. and Fischer, U. and Frints, S.G.M. and Romano, C. and Ikeuchi, Y. and Shimamura, T. and Imoto, S. and Miyano, S. and Muramatsu, S.I. and Kawauchi, T. and Hoshino, M. and Sudol, M. and Arumughan, A. and Wanker, E.E. and Rich, T. and Schwartz, C. and Matsuzaki, F. and Bonni, A. and Kalscheuer, V.M. and Okazawa, H.
Molecular Psychiatry 20 (4): 459-471. April 2015

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M. and Leitão, C. and Leisegang, M. and Chen, X. and Gavvovidis, I. and van der Bruggen, P. and Uckert, W. and Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33 (4): 402-407. April 2015

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
You, X. and Vlatkovic, I. and Babic, A. and Will, T. and Epstein, I. and Tushev, G. and Akbalik, G. and Wang, M. and Glock, C. and Quedenau, C. and Wang, X. and Hou, J. and Liu, H. and Sun, W. and Sambandan, S. and Chen, T. and Schuman, E.M. and Chen, W.
Nature Neuroscience 18 (4): 603-610. April 2015

Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.
Jantsch, J. and Schatz, V. and Friedrich, D. and Schröder, A. and Kopp, C. and Siegert, I. and Maronna, A. and Wendelborn, D. and Linz, P. and Binger, K.J. and Gebhardt, M. and Heinig, M. and Neubert, P. and Fischer, F. and Teufel, S. and David, J.P. and Neufert, C. and Cavallaro, A. and Rakova, N. and Küper, C. and Beck, F.X. and Neuhofer, W. and Muller, D.N. and Schuler, G. and Uder, M. and Bogdan, C. and Luft, F.C. and Titze, J.
Cell Metabolism 21 (3): 493-501. 3 March 2015

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.
Moussaieff, A. and Rouleau, M. and Kitsberg, D. and Cohen, M. and Levy, G. and Barasch, D. and Nemirovski, A. and Shen-Orr, S. and Laevsky, I. and Amit, M. and Bomze, D. and Elena-Herrmann, B. and Scherf, T. and Nissim-Rafinia, M. and Kempa, S. and Itskovitz-Eldor, J. and Meshorer, E. and Aberdam, D. and Nahmias, Y.
Cell Metabolism 21 (3): 392-402. 3 March 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner, E. and Daub, C.O. and Vitting-Seerup, K. and Andersson, R. and Lilje, B. and Drabløs, F. and Lennartsson, A. and Rönnerblad, M. and Hrydziuszko, O. and Vitezic, M. and Freeman, T.C. and Alhendi, A. and Arner, P. and Axton, R. and Baillie, J.K. and Beckhouse, A. and Bodega, B. and Briggs, J. and Brombacher, F. and Davis, M. and Detmar, M. and Ehrlund, A. and Endoh, M. and Eslami, A. and Fagiolini, M. and Fairbairn, L. and Faulkner, G.J. and Ferrai, C. and Fisher, M.E. and Forrester, L. and Goldowitz, D. and Guler, R. and Ha, T. and Hara, M. and Herlyn, M. and Ikawa, T. and Kai, C. and Kawamoto, H. and Khachigian, L. and Klinken, P.S. and Kojima, S. and Koseki, H. and Klein, S. and Mejhert, N. and Miyaguchi, K. and Mizuno, Y. and Morimoto, M. and Morris, K.J. and Mummery, C. and Nakachi, Y. and Ogishima, S. and Okada-Hatakeyama, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D. and Passier, R. and Patrikakis, M. and Pombo, A. and Qin, X.Y. and Roy, S. and Sato, H. and Savvi, S. and Saxena, A. and Schwegmann, A. and Sugiyama, D. and Swoboda, R. and Tanaka, H. and Tomoiu, A. and Winteringham, L.N. and Wolvetang, E. and Yanagi-Mizuochi, C. and Yoneda, M. and Zabierowski, S. and Zhang, P. and Abugessaisa, I. and Bertin, N. and Diehl, A.D. and Fukuda, S. and Furuno, M. and Harshbarger, J. and Hasegawa, A. and Hori, F. and Ishikawa-Kato, S. and Ishizu, Y. and Itoh, M. and Kawashima, T. and Kojima, M. and Kondo, N. and Lizio, M. and Meehan, T.F. and Mungall, C.J. and Murata, M. and Nishiyori-Sueki, H. and Sahin, S. and Sato-Nagao, S. and Severin, J. and de Hoon, M.J. and Kawai, J. and Kasukawa, T. and Lassmann, T. and Suzuki, H. and Kawaji, H. and Summers, K.M. and Wells, C. and Hume, D.A. and Forrest, A.R.R. and Sandelin, A. and Carninci, P. and Hayashizaki, Y.
Science 347 (6225): 1010-1014. 27 February 2015

Human promoters are intrinsically directional.
Duttke, S.H.C. and Lacadie, S.A. and Ibrahim, M.M. and Glass, C.K. and Corcoran, D.L. and Benner, C. and Heinz, S. and Kadonaga, J.T. and Ohler, U.
Molecular Cell 57 (4): 674-684. 19 February 2015

GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C. and Moroni, M. and Lima, W.C. and Wende, H. and Kirchner, M. and Adelfinger, L. and Schrenk-Siemens, K. and Tappe-Theodor, A. and Wetzel, C. and Kuich, P.H. and Gassmann, M. and Roggenkamp, D. and Bettler, B. and Lewin, G.R. and Selbach, M. and Siemens, J.
Cell 160 (4): 759-770. 12 February 2015

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P. and Korotkova, T. and Heidenreich, M. and Maier, N. and Schuetze, S. and Kobler, O. and Zuschratter, W. and Schmitz, D. and Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6 : 6254. 4 February 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T. and Hendrix, S. and Boato, F. and Smirnov, I. and Zheng, J. and Lukens, J.R. and Gadani, S. and Hechler, D. and Gölz, G. and Rosenberger, K. and Kammertöns, T. and Vogt, J. and Vogelaar, C. and Siffrin, V. and Radjavi, A. and Fernandez-Castaneda, A. and Gaultier, A. and Gold, R. and Kanneganti, T.D. and Nitsch, R. and Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.
Lluch-Senar, M. and Delgado, J. and Chen, W.-H. and Llorens-Rico, V. and O'Reilly, F.J. and Wodke, J.A.H. and Unal, E.B. and Yus, E. and Martinez, S. and Nichols, R.J. and Ferrar, T. and Vivancos, A. and Schmeisky, A. and Stuelke, J. and van Noort, V. and Gavin, A.-C. and Bork, P. and Serrano, L.
Molecular Systems Biology 11 (1): 780. 21 January 2015

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M. and Ware, J.S. and Herman, D.S. and Schafer, S. and Baksi, J. and Bick, A.G. and Buchan, R.J. and Walsh, R. and John, S. and Wilkinson, S. and Mazzarotto, F. and Felkin, L.E. and Gong, S. and MacArthur, J.A.L. and Cunningham, F. and Flannick, J. and Gabriel, S.B. and Altshuler, D.M. and Macdonald, P.S. and Heinig, M. and Keogh, A.M. and Hayward, C.S. and Banner, N.R. and Pennell, D.J. and O'Regan, D.P. and San, T.R. and de Marvao, A. and Dawes, T.J.W. and Gulati, A. and Birks, E.J. and Yacoub, M.H. and Radke, M. and Gotthardt, M. and Wilson, J.G. and O'Donnell, C.J. and Prasad, S.K. and Barton, P.J.R. and Fatkin, D. and Hubner, N. and Seidman, J.G. and Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
Baurecht, H. and Hotze, M. and Brand, S. and Büning, C. and Cormican, P. and Corvin, A. and Ellinghaus, D. and Ellinghaus, E. and Esparza-Gordillo, J. and Fölster-Holst, R. and Franke, A. and Gieger, C. and Hubner, N. and Illig, T. and Irvine, A.D. and Kabesch, M. and Lee, Y.A.E. and Lieb, W. and Marenholz, I. and McLean, W.H.I. and Morris, D.W. and Mrowietz, U. and Nair, R. and Nöthen, M.M. and Novak, N. and O'Regan, G.M. and Schreiber, S. and Smith, C. and Strauch, K. and Stuart, P.E. and Trembath, R. and Tsoi, L.C. and Weichenthal, M. and Barker, J. and Elder, J.T. and Weidinger, S. and Cordell, H.J. and Brown, S.J.
American Journal of Human Genetics 96 (1): 104-120. 8 January 2015

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
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Journal of Clinical Investigation 125 (1): 413-424. 2 January 2015

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A. and Grau, M. and Erdmann, T. and Merkel, O. and Sobhiafshar, U. and Anagnostopoulos, I. and Hummel, M. and Siegert, A. and Hayford, C. and Madle, H. and Wollert-Wulf, B. and Fichtner, I. and Dörken, B. and Dirnhofer, S. and Mathas, S. and Janz, M. and Emre, N.C.T. and Rosenwald, A. and Ott, G. and Lenz, P. and Tzankov, A. and Lenz, G.
Blood 125 (1): 124-132. 1 January 2015

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K. and Wende, H. and Prato, V. and Song, K. and Rostock, C. and Loewer, A. and Utikal, J. and Lewin, G.R. and Lechner, S.G. and Siemens, J.
Nature Neuroscience 18 (1): 10-16. January 2015

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A. and Murakawa, Y. and Rosenbaum, E. and Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade, S.S. and Woo, S.H. and Dubin, A.E. and Moshourab, R.A. and Wetzel, C. and Petrus, M. and Mathur, J. and Bégay, V. and Coste, B. and Mainquist, J. and Wilson, A.J. and Francisco, A.G. and Reddy, K. and Qiu, Z. and Wood, J.N. and Lewin, G.R. and Patapoutian, A.
Nature 516 (7529): 121-125. 4 December 2014

Paternal diet defines offspring chromatin state and intergenerational obesity.
Öst, A. and Lempradl, A. and Casas, E. and Weigert, M. and Tiko, T. and Deniz, M. and Pantano, L. and Boenisch, U. and Itskov, P.M. and Stoeckius, M. and Ruf, M. and Rajewsky, N. and Reuter, G. and Iovino, N. and Ribeiro, C. and Alenius, M. and Heyne, S. and Vavouri, T. and Pospisilik, J.A.
Cell 159 (6): 1352-1364. 4 December 2014

Cortical fosGFP expression reveals broad receptive field excitatory neurons targeted by POm.
Jouhanneau, J.S. and Ferrarese, L. and Estebanez, L. and Audette, N.J. and Brecht, M. and Barth, AL. and Poulet, J.F.A.
Neuron 84 (5): 1065-1078. 3 December 2014

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W. and Theillet, F.X. and Katzer, A. and Finzel, A. and Mishall, K.M. and Powell, A.T. and Wu, H. and Manieri, W. and Dieterich, C. and Selenko, P. and Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10 (12): 1000-1002. December 2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K. and Gätjen, M. and Grau, M. and Stache, V. and Anagnostopoulos, I. and Gerlach, K. and Niesner, R.A. and Cseresnyes, Z. and Hauser, A.E. and Lenz, P. and Hehlgans, T. and Brink, R. and Westermann, J. and Dörken, B. and Lipp, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes.
Schubert, J. and Siekierska, A. and Langlois, M. and May, P. and Huneau, C. and Becker, F. and Muhle, H. and Suls, A. and Lemke, J.R. and de Kovel, C.G.F. and Thiele, H. and Konrad, K. and Kawalia, A. and Toliat, M.R. and Sander, T. and Rueschendorf, F. and Caliebe, A. and Nagel, I. and Kohl, B. and Kecskes, A. and Jacmin, M. and Hardies, K. and Weckhuysen, S. and Riesch, E. and Dorn, T. and Brilstra, E.H. and Baulac, S. and Moller, R.S. and Hjalgrim, H. and Koeleman, B.P.C. and Jurkat-Rott, K. and Lehman-Horn, F. and Roach, J.C. and Glusman, G. and Hood, L. and Galas, D.J. and Martin, B. and de Witte, P.A.M. and Biskup, S. and De Jonghe, P. and Helbig, I. and Balling, R. and Nuernberg, P. and Crawford, A.D. and Esguerra, C.V. and Weber, Y.G. and Lerche, H.
Nature Genetics 46 (12): 1327-1332. December 2014

Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller, G. and Tap, J. and Voigt, A.Y. and Sunagawa, S. and Kultima, J.R. and Costea, P.I. and Amiot, A. and Boehm, J. and Brunetti, F. and Habermann, N. and Hercog, R. and Koch, M. and Luciani, A. and Mende, D.R. and Schneider, M.A. and Schrotz-King, P. and Tournigand, C. and Tran Van Nhieu, J. and Yamada, T. and Zimmermann, J. and Benes, V. and Kloor, M. and Ulrich, C.M. and von Knebel Doeberitz, M. and Sobhani, I. and Bork, P.
Molecular Systems Biology 10 (11): 766. 28 November 2014

A variety of dicer substrates in human and C. elegans.
Rybak-Wolf, A. and Jens, M. and Murakawa, Y. and Herzog, M. and Landthaler, M. and Rajewsky, N.
Cell 159 (5): 1153-1167. 20 November 2014

Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E. and Rother, M. and Kerr, M.C. and Al-Zeer, M.A. and Abu-Lubad, M. and Kessler, M. and Brinkmann, V. and Loewer, A. and Meyer, T.F.
Nature Communications 5 : 5201. 13 November 2014

A somatosensory circuit for cooling perception in mice.
Milenkovic, N. and Zhao, W.J. and Walcher, J. and Albert, T. and Siemens, J. and Lewin, G.R. and Poulet, J.F.A.
Nature Neuroscience 17 (11): 1560-1566. November 2014

Progressive replacement of embryo-derived cardiac macrophages with age.
Molawi, K. and Wolf, Y. and Kandalla, P.K. and Favret, J. and Hagemeyer, N. and Frenzel, K. and Pinto, A.R. and Klapproth, K. and Henri, S. and Malissen, B. and Rodewald, H.R. and Rosenthal, N.A. and Bajenoff, M. and Prinz, M. and Jung, S. and Sieweke, M.H.
Journal of Experimental Medicine 211 (11): 2151-2158. 20 October 2014

Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D. and Melick, C.H. and Clements, W.K. and Stachura, D.L. and Distel, M. and Panáková, D. and MacRae, C. and Mork, L.A. and Crump, J.G. and Traver, D.
EMBO Journal 33 (20): 2363-2373. 16 October 2014

Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Loos, M. and Mueller, T. and Gouwenberg, Y. and Wijnands, R. and van der Loo, R.J. and Birchmeier, C. and Smit, A.B. and Spijker, S.
Biological Psychiatry 76 (8): 648-655. 15 October 2014

circRNA biogenesis competes with pre-mRNA splicing.
Ashwal-Fluss, R. and Meyer, M. and Pamudurti, N.R. and Ivanov, A. and Bartok, O. and Hanan, M. and Evantal, N. and Memczak, S. and Rajewsky, N. and Kadener, S.
Molecular Cell 56 (1): 55-66. 2 October 2014

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. and Escobar, H. and Gloy, S. and Kufeld, M. and Zacher, J. and Spuler, A. and Birchmeier, C. and Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A. and Gätjen, M. and Gerlach, K. and Scholz, F. and Mensen, A. and Gloger, M. and Heinig, K. and Lamprecht, B. and Mathas, S. and Bégay, V. and Leutz, A. and Lipp, M. and Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvák, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Nature 513 (7517): 195-201. 11 September 2014

Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.
Zemojtel, T. and Koehler, S. and Mackenroth, L. and Jaeger, M. and Hecht, J. and Krawitz, P. and Graul-Neumann, L. and Doelken, S. and Ehmke, N. and Spielmann, M. and Oien, N.C. and Schweiger, M.R. and Krueger, U. and Frommer, G. and Fischer, B. and Kornak, U. and Floettmann, R. and Ardeshirdavani, A. and Moreau, Y. and Lewis, S.E. and Haendel, M. and Smedley, D. and Horn, D. and Mundlos, S. and Robinson, P.N.
Science Translational Medicine 6 (252): 252ra123. 3 September 2014

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer.
Aleksandrova, K. and Boeing, H. and Nöthlings, U. and Jenab, M. and Fedirko, V. and Kaaks, R. and Lukanova, A. and Trichopoulou, A. and Trichopoulos, D. and Boffetta, P. and Trepo, E. and Westhpal, S. and Duarte-Salles, T. and Stepien, M. and Overvad, K. and Tjønneland, A. and Halkjaer, J. and Boutron-Ruault, M.C. and Dossus, L. and Racine, A. and Lagiou, P. and Bamia, C. and Benetou, V. and Agnoli, C. and Palli, D. and Panico, S. and Tumino, R. and Vineis, P. and Bueno-de-Mesquita, B. and Peeters, P.H. and Gram, I.T. and Lund, E. and Weiderpass, E. and Quirós, J.R. and Agudo, A. and Sánchez, M.J. and Gavrila, D. and Barricarte, A. and Dorronsoro, M. and Ohlsson, B. and Lindkvist, B. and Johansson, A. and Sund, M. and Khaw, K.T. and Wareham, N. and Travis, R.C. and Riboli, E. and Pischon, T.
Hepatology 60 (3): 858-871. September 2014

Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D. and Waterhouse, P.D. and Shelton, D. and Shao, Y.W. and Watling, C.M. and Tang, Q.L. and Harris, I.S. and Dickson, B.C. and Tharmapalan, P. and Sandve, G.K. and Zhang, X. and Bailey, S.D. and Berman, H. and Wunder, J.S. and Izsvák, Z. and Lupien, M. and Mak, T.W. and Khokha, R.
Nature Genetics 46 (9): 964-972. September 2014

Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.
Stoeckius, M. and Grün, D. and Kirchner, M. and Ayoub, S. and Torti, F. and Piano, F. and Herzog, M. and Selbach, M. and Rajewsky, N.
EMBO Journal 33 (16): 1751-1766. 18 August 2014

Paternal RNA contributions in the Caenorhabditis elegans zygote.
Stoeckius, M. and Grün, D. and Rajewsky, N.
EMBO Journal 33 (16): 1740-1750. 18 August 2014

Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial.
Oettle, H. and Riess, H. and Stieler, J.M. and Heil, G. and Schwaner, I. and Seraphin, J. and Goerner, M. and Moelle, M. and Greten, T.F. and Lakner, V. and Bischoff, S. and Sinn, M. and Doerken, B. and Pelzer, U.
Journal of Clinical Oncology 32 (23): 2423-2429. 10 August 2014

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Libri, V. and Yandim, C. and Athanasopoulos, S. and Loyse, N. and Natisvili, T. and Law, P.P. and Chan, P.K. and Mohammad, T. and Mauri, M. and Tam, K.T. and Leiper, J. and Piper, S. and Ramesh, A. and Parkinson, M.H. and Huson, L. and Giunti, P. and Festenstein, R.
Lancet 384 (9942): 504-513. 9 August 2014

Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.
Mensen, A. and Jöhrens, K. and Anagnostopoulos, I. and Demski, S. and Oey, M. and Stroux, A. and Hemmati, P. and Westermann, J. and Blau, O. and Wittenbecher, F. and Movassaghi, K. and Szyska, M. and Thomas, S. and Dörken, B. and Scheibenbogen, C. and Arnold, R. and Na, I.K.
Blood 124 (6): 963-972. 7 August 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal, M. and Zheng, Y. and Hultin, S. and Audebert, S. and van Harn, T. and Johnsson, P. and Lenander, C. and Fritz, N. and Mieth, C. and Corcoran, M. and Lembo, F. and Hallstroem, M. and Hartman, J. and Mazure, N.M. and Weide, T. and Grander, D. and Borg, J.P. and Uhlen, P. and Holmgren, L.
Nature Communications 5 : 4557. 1 August 2014

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G. and Kopplin, K. and Blasig, R. and Stuiver, M. and Koning, N. and Goverse, G. and van der Pol, S.M.A. and van het Hof, B. and Gollasch, M. and Drexhage, J.A.R. and Reijerkerk, A. and Meij, I.C. and Mebius, R. and Willnow, T.E. and Müller, D. and Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128 (2): 267-277. August 2014

An integrated catalog of reference genes in the human gut microbiome.
Li, J. and Jia, H. and Cai, X. and Zhong, H. and Feng, Q. and Sunagawa, S. and Arumugam, M. and Kultima, J.R. and Prifti, E. and Nielsen, T. and Juncker, A.S. and Manichanh, C. and Chen, B. and Zhang, W. and Levenez, F. and Wang, J. and Xu, X. and Xiao, L. and Liang, S. and Zhang, D. and Zhang, Z. and Chen, W. and Zhao, H. and Al-Aama, J.Y. and Edris, S. and Yang, H. and Wang, J. and Hansen, T. and Nielsen, H.B. and Brunak, S. and Kristiansen, K. and Guarner, F. and Pedersen, O. and Dore, J. and Ehrlich, S.D. and Bork, P. and Wang, J.
Nature Biotechnology 32 (8): 834-841. August 2014

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
Nielsen, H.B. and Almeida, M. and Juncker, A.S. and Rasmussen, S. and Li, J. and Sunagawa, S. and Plichta, D.R. and Gautier, L. and Pedersen, A.G. and Le Chatelier, E. and Pelletier, E. and Bonde, I. and Nielsen, T. and Manichanh, C. and Arumugam, M. and Batto, J.M. and Quintanilha Dos Santos, M.B. and Blom, N. and Borruel, N. and Burgdorf, K.S. and Boumezbeur, F. and Casellas, F. and Dore, J. and Dworzynski, P. and Guarner, F. and Hansen, T. and Hildebrand, F. and Kaas, R.S. and Kennedy, S. and Kristiansen, K. and Kultima, J.R. and Leonard, P. and Levenez, F. and Lund, O. and Moumen, B. and Le Paslier, D. and Pons, N. and Pedersen, O. and Prifti, E. and Qin, J. and Raes, J. and Sorensen, S. and Tap, J. and Tims, S. and Ussery, D.W. and Yamada, T. and Renault, P. and Sicheritz-Ponten, T. and Bork, P. and Wang, J. and Brunak, S. and Ehrlich, S.D.
Nature Biotechnology 32 (8): 822-828. August 2014

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
Motamedi, F.J. and Badro, D.A. and Clarkson, M. and Rita Lecca, M. and Bradford, S.T. and Buske, F.A. and Saar, K. and Hübner, N. and Bräendli, A.W. and Schedl, A.
Nature Communications 5 : 4444. 17 July 2014

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly.
Belz, K. and Schoeneberger, H. and Wehner, S. and Weigert, A. and Boenig, H. and Klingebiel, T. and Fichtner, I. and Fulda, S.
Blood 124 (2): 240-250. 10 July 2014

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J. and Kassmann, M. and Szijártó, I.A. and Hercule, H.C. and Tano, J.Y. and Weinert, S. and Heidenreich, M. and Pathan, A.R. and Anistan, Y.M. and Alenina, N. and Rusch, N.J. and Bader, M. and Jentsch, T.J. and Gollasch, M.
Circulation Research 115 (2): 263-272. 7 July 2014

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V. and Furlan, A. and Shahidi, M.K. and Giovenco, M. and Kaukua, N. and Konstantinidou, C. and Pachnis, V. and Memic, F. and Marklund, U. and Müller, T. and Birchmeier, C. and Fried, K. and Ernfors, P. and Adameyko, I.
Science 345 (6192): 82-87. 4 July 2014

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M. and Agarwal, N. and Stösser, S. and Bali, K.K. and Karaulanov, E. and Kamble, R. and Pospisilova, B. and Kurejova, M. and Birchmeier, W. and Niehrs, C. and Heppenstall, P. and Kuner, R.
Neuron 83 (1): 104-121. 2 July 2014

α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N. and Kulkarni, R. and Werth, M. and Schmidt-Ott, K.M. and Forster, C. and Deng, R. and Zhang, Q. and Singer, E. and Klose, A.D. and Shen, T.H. and Francis, K.P. and Ray, S. and Vijayakumar, S. and Seward, S. and Bovino, M.E. and Xu, K. and Takabe, Y. and Amaral, F.E. and Mohan, S. and Wax, R. and Corbin, K. and Sanna-Cherchi, S. and Mori, K. and Johnson, L. and Nickolas, T. and D’Agati, V. and Lin, C.S. and Qiu, A. and Al-Awqati, Q. and Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124 (7): 2963-2976. 1 July 2014

Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.
Grosswendt, S. and Filipchyk, A. and Manzano, M. and Klironomos, F. and Schilling, M. and Herzog, M. and Gottwein, E. and Rajewsky, N.
Molecular Cell 54 (6): 1042-1054. 19 June 2014

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel, R. and Trenkwalder, T. and Petersen, B. and Husada, W. and Gesenhues, F. and Lee, S. and Hannappel, E. and Bock-Marquette, I. and Theisen, D. and Leitner, L. and Boekstegers, P. and Cierniewski, C. and Mueller, O.J. and Le Noble, F. and Adams, R.H. and Weinl, C. and Nordheim, A. and Reichart, B. and Weber, C. and Olson, E. and Posern, G. and Deindl, E. and Niemann, H. and Kupatt, C.
Nature Communications 5 : 3970. 9 June 2014

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.
Glerup, S. and Olsen, D. and Vaegter, C.B. and Gustafsen, C. and Sjoegaard, S.S. and Hermey, G. and Kjolby, M. and Molgaard, S. and Ulrichsen, M. and Boggild, S. and Skeldal, S. and Fjorback, A.N. and Nyengaard, J.R. and Jacobsen, J. and Bender, D. and Bjarkam, C.R. and Sørensen, E.S. and Füchtbauer, E.M. and Eichele, G. and Madsen, P. and Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Neuron 82 (5): 1074-87. 4 June 2014

Natural variation of histone modification and its impact on gene expression in the rat genome.
Rintisch, C. and Heinig, M. and Bauerfeind, A. and Schafer, S. and Mieth, C. and Patone, G. and Hummel, O. and Chen, W. and Cook, S. and Cuppen, E. and Colomé-Tatché, M. and Johannes, F. and Jansen, R.C. and Neil, H. and Werner, M. and Pravenec, M. and Vingron, M. and Hubner, N.
Genome Research 24 (6): 942-953. June 2014

MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H. and Schueler, M. and Munschauer, M. and Mastrobuoni, G. and Chen, W. and Kempa, S. and Dieterich, C. and Landthaler, M.
Molecular Cell 54 (4): 573-585. 22 May 2014

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K. and Ullrich, F. and Muench, J. and Lazarow, K. and Lutter, D. and Mah, N. and Andrade-Navarro, M.A. and von Kries, J.P. and Stauber, T. and Jentsch, T.J.
Science 344 (6184): 634-638. 9 May 2014

Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.
Bazzini, A.A. and Johnstone, T.G. and Christiano, R. and Mackowiak, S.D. and Obermayer, B. and Fleming, E.S. and Vejnar, C.E. and Lee, M.T. and Rajewsky, N. and Walther, T.C. and Giraldez, A.J.
EMBO Journal 33 (9): 981-993. 2 May 2014

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Aksoy, I. and Giudice, V. and Delahaye, E. and Wianny, F. and Aubry, M. and Mure, M. and Chen, J. and Jauch, R. and Bogu, G.K. and Nolden, T. and Himmelbauer, H. and Doss, M.X. and Sachinidis, A. and Schulz, H. and Hummel, O. and Martinelli, P. and Hübner, N. and Stanton, L.W. and Real, F.X. and Bourillot, P.Y. and Savatier, P.
Nature Communications 5 : 3719. 28 April 2014

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
Michalik, K.M. and You, X. and Manavski, Y. and Doddaballapur, A. and Zoernig, M. and Braun, T. and John, D. and Ponomareva, Y. and Chen, W. and Uchida, S. and Boon, R.A. and Dimmeler, S.
Circulation Research 114 (9): 1389-1397. 25 April 2014

Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole, K. and Herget, R. and Lapatsina, L. and Ngo, H.D. and Lewin, G.R.
Nature Communications 5 : 3520. 24 March 2014

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Hoegg-Beiler, M.B. and Sirisi, S. and Orozco, I.J. and Ferrer, I. and Hohensee, S. and Auberson, M. and Goedde, K. and Vilches, C. and de Heredia, M.L. and Nunes, V. and Estévez, R. and Jentsch, T.J.
Nature Communications 5 : 3475. 19 March 2014

Hexosamine pathway metabolites enhance protein quality control and prolong life.
Denzel, M.S. and Storm, N.J. and Gutschmidt, A. and Baddi, R. and Hinze, Y. and Jarosch, E. and Sommer, T. and Hoppe, T. and Antebi, A.
Cell 156 (6): 1167-1178. 13 March 2014

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
Vaeth, M. and Mueller, G. and Stauss, D. and Dietz, L. and Klein-Hessling, S. and Serfling, E. and Lipp, M. and Berberich, I. and Berberich-Siebelt, F.
Journal of Experimental Medicine 211 (3): 545-561. 10 March 2014

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D. and Rocca, E. and Oonk, A.M.M. and Schulz, H. and Rohde, E. and Bednarsch, J. and Feenstra, I. and Pennings, R.J.E. and Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124 (3): 1214-1227. 3 March 2014

Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J. and Bezzina, C.R. and Freiberg, F. and Verkerk, A.O. and Adriaens, M.E. and Podliesna, S. and Chen, C. and Purfürst, B. and Spallek, B. and Koopmann, T.T. and Baczko, I. and Dos Remedios, C.G. and George, A.L. and Bishopric, N.H. and Lodder, E.M. and de Bakker, J.M.T. and Fischer, R. and Coronel, R. and Wilde, A.A.M. and Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63 (6): 549-559. 18 February 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S. and Takagi-Niidome, S. and Liao, F. and Carlo, A.S. and Schmidt, V. and Burgert, T. and Kitago, Y. and Füchtbauer, E.M. and Füchtbauer, A. and Holtzman, D.M. and Takagi, J. and Willnow, T.E.
Science Translational Medicine 6 (223): 223ra20. 12 February 2014

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C. and Seniuk, A. and Sokolov, M.V. and Huebner, A.K. and Klementowicz, A.E. and Szijártó, I.A. and Schleifenbaum, J. and Vitzthum, H. and Gollasch, M. and Ehmke, H. and Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124 (2): 675-686. 3 February 2014

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A. and Maggio, N. and Eller, J. and Caliskan, G. and Semtner, M. and Häussler, U. and Jüttner, R. and Dugladze, T. and Smolinsky, B. and Kowalczyk, S. and Chronowska, E. and Schwarz, G. and Rathjen, F.G. and Rechavi, G. and Haas, C.A. and Kulik, A. and Gloveli, T. and Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. and McShane, E. and Cheret, C. and Walcher, J. and Müller, T. and Wulf-Goldenberg, A. and Hoelper, S. and Garratt, A.N. and Krüger, M. and Rajewsky, K. and Meijer, D. and Birchmeier, W. and Lewin, G.R. and Selbach, M. and Birchmeier, C.
Genes & Development 28 (3): 290-303. 1 February 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M. and Munschauer, M. and Gregersen, L.H. and Finzel, A. and Loewer, A. and Chen, W. and Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

Global target mRNA specification and regulation by the RNA-binding protein ZFP36.
Mukherjee, N. and Jacobs, N.C. and Hafner, M. and Kennington, E.A. and Nusbaum, J.D. and Tuschl, T. and Blackshear, P.J. and Ohler, U.
Genome Biology 15 (1): R12. 8 January 2014

Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Tattikota, S.G. and Rathjen, T. and McAnulty, S.J. and Wessels, H.H. and Akerman, I. and van de Bunt, M. and Hausser, J. and Esguerra, J.L.S. and Musahl, A. and Pandey, A.K. and You, X. and Chen, W. and Herrera, P.L. and Johnson, P.R. and O'Carroll, D. and Eliasson, L. and Zavolan, M. and Gloyn, A.L. and Ferrer, J. and Shalom-Feuerstein, R. and Aberdam, D. and Poy, M.N.
Cell Metabolism 19 (1): 122-134. 7 January 2014

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.
Cochella, L. and Tursun, B. and Hsieh, Y.W. and Galindo, S. and Johnston, R.J. and Chuang, C.F. and Hobert, O.
Genes & Development 28 (1): 34-43. 1 January 2014

Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.
Kyrø, C and Olsen, A and Landberg, R and Skeie, G and Loft, S and Åman, P and Leenders, M and Dik, VK and Siersema, PD and Pischon, T. and Christensen, J and Overvad, K and Boutron-Ruault, MC and Fagherazzi, G and Cottet, V and Kühn, T and Chang-Claude, J and Boeing, H and Trichopoulou, A and Bamia, C and Trichopoulos, D and Palli, D and Krogh, V and Tumino, R and Vineis, P and Panico, S and Peeters, PH and Weiderpass, E and Bakken, T and Åsli, LA and Argüelles, M and Jakszyn, P and Sánchez, MJ and Amiano, P and Huerta, JM and Barricarte, A and Ljuslinder, I and Palmqvist, R and Khaw, KT and Wareham, N and Key, TJ and Travis, RC and Ferrari, P and Freisling, H and Jenab, M and Gunter, MJ and Murphy, N and Riboli, E and Tjønneland, A and Bueno-de-Mesquita, HB
Journal of the National Cancer Institute 106 (1): djt352. 1 January 2014

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α.
Brooke, M.A. and Longhurst, H.J. and Plagnol, V. and Kirkby, N.S. and Mitchell, J.A. and Rüschendorf, F. and Warner, T.D. and Kelsell, D.P. and MacDonald, T.T.
Gut 63 (1): 96-104. January 2014

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.
Mehnert, M. and Sommer, T. and Jarosch, E.
Nature Cell Biology 16 (1): 77-86. January 2014

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R. and Frick, M. and Romero, R. and Korn, J.M. and Kridel, R. and Chun Chan, F. and Meissner, B. and Bhang, H.E. and Ruddy, D. and Kauffmann, A. and Farsidjani, A. and Derti, A. and Rakiec, D. and Naylor, T. and Pfister, E. and Kovats, S. and Kim, S. and Dietze, K. and Doerken, B. and Steidl, C. and Tzankov, A. and Hummel, M. and Monahan, J. and Morrissey, M.P. and Fritsch, C. and Sellers, W.R. and Cooke, V.G. and Gascoyne, R.D. and Lenz, G. and Stegmeier, F.
Nature Medicine 20 (1): 87-92. January 2014

Metagenomic species profiling using universal phylogenetic marker genes.
Sunagawa, S. and Mende, D.R. and Zeller, G. and Izquierdo-Carrasco, F. and Berger, S.A. and Kultima, J.R. and Coelho, L.P. and Arumugam, M. and Tap, J. and Nielsen, H.B. and Rasmussen, S. and Brunak, S. and Pedersen, O. and Guarner, F. and de Vos, W.M. and Wang, J. and Li, J. and Dore, J. and Ehrlich, S.D. and Stamatakis, A. and Bork, P.
Nature Methods 10 (12): 1196-1199. December 2013

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G. and Milić, J and Eldahshan, A and Götz, F. and Zühlke, K. and Schillinger, C. and Kreuchwig, A. and Elkins, J.M. and Abdul Azeez, K.R.A. and Oder, A. and Moutty, M.C. and Masada, N. and Beerbaum, M. and Schlegel, B. and Niquet, S. and Schmieder, P. and Krause, G. and von Kries, J.P. and Cooper, D.M.F. and Knapp, S. and Rademann, J. and Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C. and Heemskerk, B. and Kvistborg, P. and Kluin, R.J.C. and Bolotin, D.A. and Chen, X. and Bresser, K. and Nieuwland, M. and Schotte, R. and Michels, S. and Gomez-Eerland, R. and Jahn, L. and Hombrink, P. and Legrand, N. and Shu, C.J. and Mamedov, I.Z. and Velds, A. and Blank, C.U. and Haanen, J.B.A.G. and Turchaninova, M.A. and Kerkhoven, R.M. and Spits, H. and Hadrup, S.R. and Heemskerk, M.H.M. and Blankenstein, T. and Chudakov, D.M. and Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19 (11): 1534-1541. November 2013

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M. and Landles, C. and Weiss, A. and Bradaia, A. and Seredenina, T. and Inuabasi, L. and Osborne, G.F. and Wadel, K. and Touller, C. and Butler, R. and Robertson, J. and Franklin, S.A. and Smith, D.L. and Park, L. and Marks, P.A. and Wanker, E.E. and Olson, E.N. and Luthi-Carter, R. and van der Putten, H. and Beaumont, V. and Bates, G.P.
PLoS Biology 11 (11): e1001717. November 2013

Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.
Nordlinger, B. and Sorbye, H. and Glimelius, B. and Poston, G.J. and Schlag, P.M. and Rougier, P. and Bechstein, W.O. and Primrose, J.N. and Walpole, E.T. and Finch-Jones, M. and Jaeck, D. and Mirza, D. and Parks, R.W. and Mauer, M. and Tanis, E. and Van Cutsem, E. and Scheithauer, W. and Gruenberger, T.
Lancet Oncology 14 (12): 1208-1215. November 2013

BMP signaling controls muscle mass.
Sartori, R. and Schirwis, E. and Blaauw, B. and Bortolanza, S. and Zhao, J. and Enzo, E. and Stantzou, A. and Mouisel, E. and Toniolo, L. and Ferry, A. and Stricker, S. and Goldberg, A.L. and Dupont, S. and Piccolo, S. and Amthor, H. and Sandri, M.
Nature Genetics 45 (11): 1309-1318. November 2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Saunders, S.P. and Goh, C.S.M. and Brown, S.J. and Palmer, C.N.A. and Porter, R.M. and Cole, C. and Campbell, L.E. and Gierlinski, M. and Barton, G.J. and Schneider, G. and Balmain, A. and Prescott, A.R. and Weidinger, S. and Baurecht, H. and Kabesch, M. and Gieger, C. and Lee, Y.A. and Tavendale, R. and Mukhopadhyay, S. and Turner, S.W. and Madhok, V.B. and Sullivan, F.M. and Relton, C. and Burn, J. and Meggitt, S. and Smith, C.H. and Allen, M.A. and Barker, J.N.W.N. and Reynolds, N.J. and Cordell, H.J. and Irvine, A.D. and McLean, W.H.I. and Sandilands, A. and Fallon, P.G.
Journal of Allergy and Clinical Immunology 132 (5): 1121-1129. November 2013

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Scheller, M. and Schönheit, J. and Zimmermann, K. and Leser, U. and Rosenbauer, F. and Leutz, A.
Journal of Experimental Medicine 210 (11): 2239-2256. 21 October 2013

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. and Yu, Y. and Milanovic, M. and Beuster, G. and Zasada, C. and Däbritz, J.H.M. and Lisec, J. and Lenze, D. and Gerhardt, A. and Schleicher, K. and Kratzat, S. and Purfürst, B. and Walenta, S. and Mueller-Klieser, W. and Gräler, M. and Hummel, M. and Keller, U. and Buck, A.K. and Dörken, B. and Willmitzer, L. and Reimann, M. and Kempa, S. and Lee, S. and Schmitt, C.A.
Nature 501 (7467): 421-425. 19 September 2013

Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.
Beed, P. and Gundlfinger, A. and Schneiderbauer, S. and Song, J. and Boehm, C. and Burgalossi, A. and Brecht, M. and Vida, I. and Schmitz, D.
Neuron 79 (6): 1197-1207. 18 September 2013

Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.
Kintscher, M. and Wozny, C. and Johenning, F.W. and Schmitz, D. and Breustedt, J.
Nature Communications 4 : 2392. 3 September 2013

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E. and Mah, N. and Naumann, H. and Pongrac, I.M. and Cerdá-Esteban, N. and Fontaine, J.F. and Wang, Y. and Chen, W. and Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27 (17): 1932-1946. 1 September 2013

Accurate and universal delineation of prokaryotic species.
Mende, D.R. and Sunagawa, S. and Zeller, G. and Bork, P.
Nature Methods 10 (9): 881-884. September 2013

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I. and Gross, J. and Baumann, D. and Korn, C. and Kerr, G. and Grigoryan, T. and Mauch, C. and Birchmeier, W. and Boutros, M.
Journal of Experimental Medicine 210 (9): 1761-1777. 26 August 2013

Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits.
Megraw, M. and Mukherjee, S. and Ohler, U.
Genome Biology 14 (8): R85. 23 August 2013

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur, S.S. and Diaz, A.G. and Maratou, K. and Sarkis, A. and Rotival, M. and Game, L. and Tschannen, M.R. and Kaisaki, P.J. and Otto, G.W. and John Ma, M.C. and Keane, T.M. and Hummel, O. and Saar, K. and Chen, W. and Guryev, V. and Gopalakrishnan, K. and Garrett, M.R. and Joe, B. and Citterio, L. and Bianchi, G. and McBride, M. and Dominiczak, A. and Adams, D.J. and Serikawa, T. and Flicek, P. and Cuppen, E. and Hubner, N. and Petretto, E. and Gauguier, D. and Kwitek, A. and Jacob, H. and Aitman, T.J.
Cell 154 (3): 691-703. 1 August 2013

Orchestrated intron retention regulates normal granulocyte differentiation.
Wong, J.J.L. and Ritchie, W. and Ebner, O.A. and Selbach, M. and Wong, J.W.H. and Huang, Y. and Gao, D. and Pinello, N. and Gonzalez, M. and Baidya, K. and Thoeng, A. and Khoo, T.L. and Bailey, C.G. and Holst, J. and Rasko, J.E.J.
Cell 154 (3): 583-595. 1 August 2013

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo, J. and Schaarschmidt, H. and Liang, L. and Cookson, W. and Bauerfeind, A. and Lee-Kirsch, M.A. and Nemat, K. and Henderson, J. and Paternoster, L. and Harper, J.L. and Mangold, E. and Nothen, M.M. and Rüschendorf, F. and Kerscher, T. and Marenholz, I. and Matanovic, A. and Lau, S. and Keil, T. and Bauer, C.P. and Kurek, M. and Ciechanowicz, A. and Macek, M. and Franke, A. and Kabesch, M. and Hubner, N. and Abecasis, G. and Weidinger, S. and Moffatt, M. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 132 (2): 371-377. August 2013

Bio++: efficient extensible libraries and tools for computational molecular evolution.
Gueguen, L. and Gaillard, S. and Boussau, B. and Gouy, M. and Groussin, M. and Rochette, N.C. and Bigot, T. and Fournier, D. and Pouyet, F. and Cahais, V. and Bernard, A. and Scornavacca, C. and Nabholz, B. and Haudry, A. and Dachary, L. and Galtier, N. and Belkhir, K. and Dutheil, J.Y.
Molecular Biology and Evolution 30 (8): 1745-1750. August 2013

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice.
Krebs, K. and Böttinger, N. and Huang, L.R. and Chmielewski, M. and Arzberger, S. and Gasteiger, G. and Jäger, C. and Schmitt, E. and Bohne, F. and Aichler, M. and Uckert, W. and Abken, H. and Heikenwalder, M. and Knolle, P. and Protzer, U.
Gastroenterology 145 (2): 456-465. August 2013

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C. and Willem, M. and Fricker, F.R. and Wende, H. and Wulf-Goldenberg, A. and Tahirovic, S. and Nave, K.A. and Saftig, P. and Haass, C. and Garratt, A.N. and Bennett, D.L. and Birchmeier, C.
EMBO Journal 32 (14): 2015-2028. 17 July 2013

Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun, W. and You, X. and Gogol-Doering, A. and He, H. and Kise, Y. and Sohn, M. and Chen, T. and Klebes, A. and Schmucker, D. and Chen, W.
EMBO Journal 32 (14): 2029-2038. 17 July 2013

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P. and Fang, L. and Zhu, Q. and Schipper, J.H. and Loddenkemper, C. and Kosel, F. and Brinkmann, V. and Eckert, K. and Hindersin, S. and Holland, J.D. and Lehr, S. and Kahn, M. and Ziebold, U. and Birchmeier, W.
EMBO Journal 32 (14): 1977-1989. 17 July 2013

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
Meder, B. and Rühle, F. and Weis, T. and Homuth, G. and Keller, A. and Franke, J. and Peil, B. and Bermejo, J.L. and Frese, K. and Huge, A. and Witten, A. and Vogel, B. and Haas, J. and Völker, U. and Ernst, F. and Teumer, A. and Ehlermann, P. and Zugck, C. and Friedrichs, F. and Kroemer, H. and Dörr, M. and Hoffmann, W. and Maisch, B. and Pankuweit, S. and Ruppert, V. and Scheffold, T. and Kühl, U. and Schultheiss, H.P. and Kreutz, R. and Ertl, G. and Angermann, C. and Charron, P. and Villard, E. and Gary, F. and Isnard, R. and Komajda, M. and Lutz, M. and Meitinger, T. and Sinner, M.F. and Wichmann, H.E. and Krawczak, M. and Ivandic, B. and Weichenhan, D. and Gelbrich, G. and El-Mokhtari, N.E. and Schreiber, S. and Felix, S.B. and Hasenfuß, G. and Pfeufer, A. and Hübner, N. and Kääb, S. and Arbustini, E. and Rottbauer, W. and Frey, N. and Stoll, M. and Katus, H.A.
European Heart Journal 35 (16): 1069-1077. 12 July 2013

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Arndt, A.K. and Schaefer, S. and Drenckhahn, J.D. and Sabeh, M.K. and Plovie, E.R. and Caliebe, A. and Klopocki, E. and Musso, G. and Werdich, A.A. and Kalwa, H. and Heinig, M. and Padera, R.F. and Wassilew, K. and Bluhm, J. and Harnack, C. and Martitz, J. and Barton, P.J. and Greutmann, M. and Berger, F. and Huebner, N. and Siebert, R. and Kramer, H.H. and Cook, S.A. and Macrae, C.A. and Klaassen, S.
American Journal of Human Genetics 93 (1): 67-77. 11 July 2013

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M. and Weissbrich, B. and Knall, R. and Franz, T. and Dössinger, G. and Bet, J. and Paszkiewicz, P.J. and Pfeifer, L. and Bunse, M. and Uckert, W. and Holtappels, R. and Gillert-Marien, D. and Neuenhahn, M. and Krackhardt, A. and Reddehase, M.J. and Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H and Schröder, A and Neuhofer, W and Jantsch, J and Kopp, C and Karlsen, T.V. and Boschmann, M and Goss, J and Bry, M and Rakova, N and Dahlmann, A and Brenner, S and Tenstad, O and Nurmi, H and Mervaala, E and Wagner, H and Beck, FX and Müller, D.N. and Kerjaschki, D and Luft, F.C. and Harrison, D.G. and Alitalo, K and Titze, J
Journal of Clinical Investigation 123 (7): 2803-2815. 1 July 2013

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud, A. and Hermsen, R. and Guryev, V. and Stridh, P. and Graham, D. and McBride, M.W. and Foroud, T. and Calderari, S. and Diez, M. and Ockinger, J. and Beyeen, A.D. and Gillett, A. and Abdelmagid, N. and Guerreiro-Cacais, A.O. and Jagodic, M. and Tuncel, J. and Norin, U. and Beattie, E. and Huynh, N. and Miller, W.H. and Koller, D.L. and Alam, I. and Falak, S. and Osborne-Pellegrin, M. and Martinez-Membrives, E. and Canete, T. and Blazquez, G. and Vicens-Costa, E. and Mont-Cardona, C. and Diaz-Moran, S. and Tobena, A. and Hummel, O. and Zelenika, D. and Saar, K. and Patone, G. and Bauerfeind, A. and Bihoreau, M.T. and Heinig, M. and Lee, Y.A. and Rintisch, C. and Schulz, H. and Wheeler, D.A. and Worley, K.C. and Muzny, D.M. and Gibbs, R.A. and Lathrop, M. and Lansu, N. and Toonen, P. and Ruzius, F.P. and de Bruijn, E. and Hauser, H. and Adams, D.J. and Keane, T. and Atanur, S.S. and Aitman, T.J. and Flicek, P. and Malinauskas, T. and Jones, E.Y. and Ekman, D. and Lopez-Aumatell, R. and Dominiczak, A.F. and Johannesson, M. and Holmdahl, R. and Olsson, T. and Gauguier, D. and Hubner, N. and Fernandez-Teruel, A. and Cuppen, E. and Mott, R. and Flint, J.
Nature Genetics 45 (7): 767-775. July 2013

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Ellinghaus, D. and Baurecht, H. and Esparza-Gordillo, J. and Rodríguez, E. and Matanovic, A. and Marenholz, I. and Hübner, N. and Schaarschmidt, H. and Novak, N. and Michel, S. and Maintz, L. and Werfel, T. and Meyer-Hoffert, U. and Hotze, M. and Prokisch, H. and Heim, K. and Herder, C. and Hirota, T. and Tamari, M. and Kubo, M. and Takahashi, A. and Nakamura, Y. and Tsoi, L.C. and Stuart, P. and Elder, J.T. and Sun, L. and Zuo, X. and Yang, S. and Zhang, X. and Hoffmann, P. and Nöthen, M.M. and Fölster-Holst, R. and Winkelmann, J. and Illig, T. and Boehm, B.O. and Duerr, R.H. and Büning, C. and Brandt, S. and Glas, J. and McAleer, M.A. and Fahy, C.M. and Kabesch, M. and Brown, S. and McLean, W.H.I. and Irvine, A.D. and Schreiber, S. and Lee, Y.A. and Franke, A. and Weidinger, S.
Nature Genetics 45 (7): 808-812. July 2013

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.
Fricker, F.R. and Antunes-Martins, A. and Galino, J. and Paramsothy, R. and La Russa, F. and Perkins, J. and Goldberg, R. and Brelstaff, J. and Zhu, N. and McMahon, S.B. and Orengo, C. and Garratt, A.N. and Birchmeier, C. and Bennett, D.L.
Brain 136 (Pt 7): 2279-2297. July 2013

MicroRNA target site identification by integrating sequence and binding information.
Majoros, W.H. and Lekprasert, P. and Mukherjee, N. and Skalsky, R.L. and Corcoran, D.L. and Cullen, B.R. and Ohler, U.
Nature Methods 10 (7): 630-633. July 2013

The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
Cecere, G. and Hoersch, S. and Jensen, M.B. and Dixit, S. and Grishok, A.
Molecular Cell 50 (6): 894-907. 27 June 2013

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Bagola, K. and von Delbrück, M. and Dittmar, G. and Scheffner, M. and Ziv, I. and Glickman, M.H. and Ciechanover, A. and Sommer, T.
Molecular Cell 50 (4): 528-539. 23 May 2013

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N. and Sarrazin, S. and Kandalla, P.K. and Espinosa, L. and Stanley, E.R. and Nutt, S.L. and Moore, J. and Sieweke, M.H.
Nature 497 (7448): 239-243. 9 May 2013

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C. and Grabiger, S. and Schwefel, D. and Faelber, K. and Rosenbaum, E. and Mears, J. and Rocks, O. and Daumke, O.
EMBO Journal 32 (9): 1280-1292. 2 May 2013

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld, M. and Manzel, A. and Titze, J. and Kvakan, H. and Yosef, N. and Linker, R.A. and Muller, D.N. and Hafler, D.A.
Nature 496 (7446): 518-522. 25 April 2013

Discovery and characterization of alamandine, a novel component of the renin-angiotensin system.
Lautner, R.Q. and Villela, D.C. and Fraga-Silva, R.A. and Silva, N.C. and Verano-Braga, T. and Costa-Fraga, F. and Jankowski, J. and Jankowski, V. and De Sousa, F.B. and Alzamora, A.C. and Soares, E.R. and Barbosa, C.M. and Kjeldsen, F. and Oliveira, A.C. and Braga, J.F. and Savergnini, S.Q. and Etelvino, G.M. and Bastos Peluso, A.A. and Passos-Silva, D.G. and Ferreira, A.J. and Alves, F. and Martins, A.S. and Raizada, M.K. and Paula, R.D. and Motta-Santos, D. and Klempin, F. and Pimenta, A.M.C. and Alenina, N. and Sinisterra, R.D.M. and Bader, M. and Campagnole-Santos, M.J. and Santos, R.A.S.
Circulation Research 112 (8): 1104-1111. 12 April 2013

A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M. and Grossmann, A. and Woodsmith, J. and Özkan, Z. and Birth, P. and Meierhofer, D. and Benlasfer, N. and Valovka, T. and Timmermann, B. and Wanker, E.E. and Sauer, S. and Stelzl, U.
Nature Methods 10 (4): 339-342. April 2013

Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry.
Veerkamp, J. and Rudolph, F. and Cseresnyes, Z. and Priller, F. and Otten, C. and Renz, M. and Schaefer, L. and Abdelilah-Seyfried, S.
Developmental Cell 24 (6): 660-667. 25 March 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Mueller-Rischart, A.K. and Pilsl, A. and Beaudette, P. and Patra, M. and Hadian, K. and Funke, M. and Peis, R. and Deinlein, A. and Schweimer, C. and Kuhn, P.H. and Lichtenthaler, S.F. and Motori, E. and Hrelia, S. and Wurst, W and Truembach, D. and Langer, T. and Krappmann, D. and Dittmar, G. and Tatzelt, J. and Winklhofer, K.F.
Molecular Cell 49 (5): 908-921. 7 March 2013

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Staber, P.B. and Zhang, P. and Ye, M. and Welner, R.S. and Nombela-Arrieta, C. and Bach, C. and Kerenyi, M. and Bartholdy, B.A. and Zhang, H. and Alberich-Jorda, M. and Lee, S. and Yang, H. and Ng, F. and Zhang, J. and Leddin, M. and Silberstein, L.E. and Hoefler, G. and Orkin, S.H. and Goettgens, B. and Rosenbauer, F. and Huang, G. and Tenen, D.G.
Molecular Cell 49 (5): 934-946. 7 March 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A. and Qadri, F. and Leukel, L. and Yilmaz, R. and Fontaine, J.F. and Sihn, G. and Bader, M. and Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123 (3): 1343-1347. 1 March 2013

Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G. and Schmidt, K. and Loddenkemper, C. and Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123 (3): 1032-1043. 1 March 2013

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Kierdorf, K. and Erny, D. and Goldmann, T. and Sander, V. and Schulz, C. and Perdiguero, E.G. and Wieghofer, P. and Heinrich, A. and Riemke, P. and Hoelscher, C. and Müller, D.N. and Luckow, B. and Brocker, T. and Debowski, K. and Fritz, G. and Opdenakker, G. and Diefenbach, A. and Biber, K. and Heikenwalder, M. and Geissmann, F. and Rosenbauer, F. and Prinz, M.
Nature Neuroscience 16 (3): 273-280. March 2013

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S. and Griesche, N. and Jastrzebska, E. and Chen, C. and Rutschow, D. and Achmüller, C. and Dorn, S. and Boesch, S.M. and Lalowski, M. and Wanker, E. and Schneider, R. and Schweiger, S.
Nature Communications 4 : 1511. 26 February 2013

Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S. and Schneider, J. and Wollersheim, T. and Assmann, A. and Bierbrauer, J. and Marg, A. and Al Hasani, H. and Chadt, A. and Wenzel, K. and Koch, S. and Fielitz, J. and Kleber, C. and Faust, K. and Mai, K. and Spies, C.D. and Luft, F.C. and Boschmann, M. and Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396. 15 February 2013

Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.
Anton, F. and Dittmar, G. and Langer, T. and Escobar-Henriques, M.
Molecular Cell 49 (3): 487-498. 7 February 2013

Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease.
Kränkel, N. and Kuschnerus, K. and Müller, M. and Speer, T. and Mocharla, P. and Madeddu, P. and Bader, M. and Lüscher, T.F. and Landmesser, U.
Circulation 127 (5): 594-603. 5 February 2013

ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
An, J. and Mehrhof, F. and Harms, C. and Laettig-Tuennemann, G. and Lee, S.L.L. and Endres, M. and Li, M. and Sellge, G. and Mandic, A.D. and Trautwein, C. and Donath, S.
Journal of Hepatology 58 (2): 297-305. February 2013

(90)Yttrium-ibritumomab-tiuxetan as first-line treatment for follicular lymphoma: 30 months of follow-up data from an international multicenter phase II clinical trial.
Scholz, C.W. and Pinto, A. and Linkesch, W. and Lindén, O. and Viardot, A. and Keller, U. and Hess, G. and Lastoria, S. and Lerch, K. and Frigeri, F. and Arcamone, M. and Stroux, A. and Frericks, B. and Pott, C. and Pezzutto, A.
Journal of Clinical Oncology 31 (3): 308-313. 20 January 2013

Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes.
Uhlenhaut, N.H. and Barish, G.D. and Yu, R.T. and Downes, M. and Karunasiri, M. and Liddle, C. and Schwalie, P. and Hübner, N. and Evans, R.M.
Molecular Cell 49 (1): 158-171. 10 January 2013

Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Rakova, N. and Jüttner, K. and Dahlmann, A. and Schröder, A. and Linz, P. and Kopp, C. and Rauh, M. and Goller, U. and Beck, L. and Agureev, A. and Vassilieva, G. and Lenkova, L. and Johannes, B. and Wabel, P. and Moissl, U. and Vienken, J. and Gerzer, R. and Eckardt, K.U. and Müller, D.N. and Kirsch, K. and Morukov, B. and Luft, F.C. and Titze, J.
Cell Metabolism 17 (1): 125-131. 8 January 2013

Genomic variation landscape of the human gut microbiome.
Schloissnig, S. and Arumugam, M. and Sunagawa, S. and Mitreva, M. and Tap, J. and Zhu, A. and Waller, A. and Mende, D.R. and Kultima, J.R. and Martin, J. and Kota, K. and Sunyaev, S.R. and Weinstock, G.M. and Bork, P.
Nature 493 (7430): 45-50. 3 January 2013

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
Kravtsova-Ivantsiv, Y. and Sommer, T. and Ciechanover, A.
Angewandte Chemie International Edition 52 (1): 192-198. 2 January 2013

A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice.
Baddack, U. and Hartmann, S. and Bang, H. and Grobe, J. and Loddenkemper, C. and Lipp, M. and Mueller, G.
Nature Communications 4 : 1644. 2013

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K. and Nakamura, Y. and Oka, T. and Ito, H. and Tamura, T. and Tagawa, K. and Sasabe, T. and Katsuta, A. and Motoki, K. and Shiwaku, H. and Sone, M. and Yoshida, C. and Katsuno, M. and Eishi, Y. and Murata, M. and Taylor, J.P. and Wanker, E.E. and Kono, K. and Tashiro, S. and Sobue, G. and La Spada, A.R. and Okazawa, H.
Nature Communications 4 : 1816. 2013

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.
Iskar, M. and Zeller, G. and Blattmann, P. and Campillos, M. and Kuhn, M. and Kaminska, K.H. and Runz, H. and Gavin, A.C. and Pepperkok, R. and van Noort, V. and Bork, P.
Molecular Systems Biology 9 : 662. 2013

Systematic identification of proteins that elicit drug side effects.
Kuhn, M. and Al Banchaabouchi, M. and Campillos, M. and Jensen, L.J. and Gross, C. and Gavin, A.C. and Bork, P.
Molecular Systems Biology 9 : 663. 2013

Widespread splicing changes in human brain development and aging.
Mazin, P. and Xiong, J. and Liu, X. and Yan, Z. and Zhang, X. and Li, M. and He, L. and Somel, M. and Yuan, Y. and Chen, Y.P.P. and Li, N. and Hu, Y. and Fu, N. and Ning, Z. and Zeng, R. and Yang, H. and Chen, W. and Gelfand, M. and Khaitovich, P.
Molecular Systems Biology 9 : 633. 2013

Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Herse, F. and LaMarca, B. and Hubel, C.A. and Kaartokallio, T. and Lokki, A.I. and Ekholm, E. and Laivuori, H. and Gauster, M. and Huppertz, B. and Sugulle, M. and Ryan, M.J. and Novotny, S. and Brewer, J. and Park, J.K. and Kacik, M. and Hoyer, J. and Verlohren, S. and Wallukat, G. and Rothe, M. and Luft, F.C. and Muller, D.N. and Schunck, W.H. and Staff, A.C. and Dechend, R.
Circulation 126 (25): 2990-2999. 18 December 2012

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Nagel, D. and Spranger, S. and Vincendeau, M. and Grau, M. and Raffegerst, S. and Kloo, B. and Hlahla, D. and Neuenschwander, M. and von Kries, J.P. and Hadian, K. and Doerken, B. and Lenz, P. and Lenz, G. and Schendel, D.J. and Krappmann, D.
Cancer Cell 22 (6): 825-837. 11 December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S. and Raczkowski, F. and Mittruecker, H.W. and Willimsky, G. and Gerlach, K. and Kuehl, A.A. and Breiderhoff, T. and Willnow, T.E. and Doerken, B. and Hoepken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G. and Rump, A. and Schulz, H. and Stricker, S. and Schulze, L. and Platzer, K. and Aydin, A. and Tinschert, S. and Goldring, M.B. and Luft, F.C. and Baehring, S.
Journal of Clinical Investigation 122 (11): 3990-4002. 1 November 2012

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P. and Sasaki, Y. and Godinho, S.A. and Pellerin, A. and Koechert, K. and Sleckman, B.P. and de Alboran, I.M. and Janz, M. and Rodig, S. and Rajewsky, K.
Nature Immunology 13 (11): 1092-1100. November 2012

Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat, S. and Schmidt, A. and Codlin, S. and Chen, W. and Aebersold, R. and Baehler, J.
Cell 151 (3): 671-683. 26 October 2012

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
Kaji, T. and Ishige, A. and Hikida, M. and Taka, J. and Hijikata, A. and Kubo, M. and Nagashima, T. and Takahashi, Y. and Kurosaki, T. and Okada, M. and Ohara, O. and Rajewsky, K. and Takemori, T.
Journal of Experimental Medicine 209 (11): 2079-2097. 22 October 2012

A validated regulatory network for Th17 cell specification.
Ciofani, M. and Madar, A. and Galan, C. and Sellars, M. and Mace, K. and Pauli, F. and Agarwal, A. and Huang, W. and Parkurst, C.N. and Muratet, M. and Newberry, K.M. and Meadows, S. and Greenfield, A. and Yang, Y. and Jain, P. and Kirigin, F.K. and Birchmeier, C. and Wagner, E.F. and Murphy, K.M. and Myers, R.M. and Bonneau, R. and Littman, D.R.
Cell 151 (2): 289-303. 12 October 2012

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.
Shabek, N. and Herman-Bachinsky, Y. and Buchsbaum, S. and Lewinson, O. and Haj-Yahya, M. and Hejjaoui, M. and Lashuel, H.A. and Sommer, T. and Brik, A. and Ciechanover, A.
Molecular Cell 48 (1): 87-97. 12 October 2012

Novel biomarkers for pre-diabetes identified by metabolomics.
Wang-Sattler, R. and Yu, Z. and Herder, C. and Messias, A.C. and Floegel, A. and He, Y. and Heim, K. and Campillos, M. and Holzapfel, C. and Thorand, B. and Grallert, H. and Xu, T. and Bader, E. and Huth, C. and Mittelstrass, K. and Doering, A. and Meisinger, C. and Gieger, C. and Prehn, C. and Roemisch-Margl, W. and Carstensen, M. and Xie, L. and Yamanaka-Okumura, H. and Xing, G. and Ceglarek, U. and Thiery, J. and Giani, G. and Lickert, H. and Lin, X. and Li, Y. and Boeing, H. and Joost, H.G. and de Angelis, M.H. and Rathmann, W. and Suhre, K. and Prokisch, H. and Peters, A. and Meitinger, T. and Roden, M. and Wichmann, H.E. and Pischon, T. and Adamski, J. and Illig, T.
Molecular Systems Biology 8 : 615. 25 September 2012

Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D. and Vasyutina, E. and Czajkowski, M.T. and Griger, J. and Rassek, C. and Rahn, H.P. and Purfuerst, B. and Wende, H. and Birchmeier, C.
Developmental Cell 23 (3): 469-481. 11 September 2012

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51 (37): 9441-9447. 10 September 2012

Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Sander, S. and Calado, D.P. and Srinivasan, L. and Koechert, K. and Zhang, B. and Rosolowski, M. and Rodig, S.J. and Holzmann, K. and Stilgenbauer, S. and Siebert, R. and Bullinger, L. and Rajewsky, K.
Cancer Cell 22 (2): 167-179. 14 August 2012

Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M. and Schuster, S. and Juettner, R. and Parthasarathy, S. and Tarabykin, V. and Birchmeier, W.
Genes & Development 26 (15): 1743-1757. 1 August 2012

TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure.
An, J. and Harms, C. and Laettig-Tuennemann, G. and Sellge, G. and Mandic, A.D. and Malato, Y. and Heuser, A. and Endres, M. and Trautwein, C. and Donath, S.
Hepatology 56 (2): 715-726. August 2012

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K. and Kumar, J. and Synowitz, M. and Petrosino, S. and Imperatore, R. and Smith, E.S.J. and Wend, P. and Purfuerst, B. and Nuber, U.A. and Gurok, U. and Matyash, V. and Waelzlein, J.H. and Chirasani, S.R. and Dittmar, G. and Cravatt, B.F. and Momma, S. and Lewin, G.R. and Ligresti, A. and De Petrocellis, L. and Cristino, L. and Di Marzo, V. and Kettenmann, H. and Glass, R.
Nature Medicine 18 (8): 1232-1238. August 2012

Deciphering a global network of functionally associated post-translational modifications.
Minguez, P. and Parca, L. and Diella, F. and Mende, D.R. and Kumar, R. and Helmer-Citterich, M. and Gavin, A.C. and van Noort, V. and Bork, P.
Molecular Systems Biology 8 : 599. 17 July 2012

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Bywater, M.J. and Poortinga, G. and Sanij, E. and Hein, N. and Peck, A. and Cullinane, C. and Wall, M. and Cluse, L. and Drygin, D. and Anderes, K. and Huser, N. and Proffitt, C. and Bliesath, J. and Haddach, M. and Schwaebe, M.K. and Ryckman, D.M. and Rice, W.G. and Schmitt, C. and Lowe, S.W. and Johnstone, R.W. and Pearson, R.B. and McArthur, G.A. and Hannan, R.D.
Cancer Cell 22 (1): 51-65. 10 July 2012

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G. and Munschauer, M. and Schwanhaeusser, B. and Vasile, A. and Murakawa, Y. and Schueler, M. and Youngs, N. and Penfold-Brown, D. and Drew, K. and Milek, M. and Wyler, E. and Bonneau, R. and Selbach, M. and Dieterich, C. and Landthaler, M.
Molecular Cell 46 (5): 674-690. 8 June 2012

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.
Dizier, M.H. and Margaritte-Jeannin, P. and Madore, A.M. and Esparza-Gordillo, J. and Moffatt, M.F. and Corda, E. and Monier, F. and Guilloud-Bataille, M. and Franke, A. and Weidinger, S. and Annesi-Maesano, I. and Just, J. and Pin, I. and Kauffmann, F. and Cookson, W. and Lee, Y.A. and Laprise, C. and Lathrop, M. and Bouzigon, E. and Demenais, F.
Journal of Allergy and Clinical Immunology 129 (6): 1547-1553. June 2012

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann, S.M. and Krueger, C. and Park, B. and Derkow, K. and Rosenberger, K. and Baumgart, J. and Trimbuch, T. and Eom, G. and Hinz, M. and Kaul, D. and Habbel, P. and Kaelin, R. and Franzoni, E. and Rybak, A. and Nguyen, D. and Veh, R. and Ninnemann, O. and Peters, O. and Nitsch, R. and Heppner, F.L. and Golenbock, D. and Schott, E. and Ploegh, H.L. and Wulczyn, F.G. and Lehnardt, S.
Nature Neuroscience 15 (6): 827-835. June 2012

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
Engert, A. and Haverkamp, H. and Kobe, C. and Markova, J. and Renner, C. and Ho, A. and Zijlstra, J. and Kral, Z. and Fuchs, M. and Hallek, M. and Kanz, L. and Doehner, H. and Doerken, B. and Engel, N. and Topp, M. and Klutmann, S. and Amthauer, H. and Bockisch, A. and Kluge, R. and Kratochwil, C. and Schober, O. and Greil, R. and Andreesen, R. and Kneba, M. and Pfreundschuh, M. and Stein, H. and Eich, H.T. and Mueller, R.P. and Dietlein, M. and Borchmann, P. and Diehl, V.
Lancet 379 (9828): 1791-1799. 12 May 2012

Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours.
Yamada, T. and Waller, A.S. and Raes, J. and Zelezniak, A. and Perchat, N. and Perret, A. and Salanoubat, M. and Patil, K.R. and Weissenbach, J. and Bork, P.
Molecular Systems Biology 8 : 581. 8 May 2012

A role for GPx3 in activity of normal and leukemia stem cells.
Herault, O. and Hope, K.J. and Deneault, E. and Mayotte, N. and Chagraoui, J. and Wilhelm, B.T. and Cellot, S. and Sauvageau, M. and Andrade-Navarro, M.A. and Hebert, J. and Sauvageau, G.
Journal of Experimental Medicine 209 (5): 895-901. 7 May 2012

A genetic basis for mechanosensory traits in humans.
Frenzel, H. and Bohlender, J. and Pinsker, K. and Wohlleben, B. and Tank, J. and Lechner, S.G. and Schiska, D. and Jaijo, T. and Rueschendorf, F. and Saar, K. and Jordan, J. and Millan, J.M. and Gross, M. and Lewin, G.R.
PLoS Biology 10 (5): e1001318. 1 May 2012

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
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Nature Medicine 18 (5): 766-773. May 2012

The determinants of tumour immunogenicity.
Blankenstein, T. and Coulie, P.G. and Gilboa, E. and Jaffee, E.M.
Nature Reviews Cancer 12 (4): 307-313. April 2012

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu, X. and Somel, M. and Tang, L. and Yan, Z. and Jiang, X. and Guo, S. and Yuan, Y.P. and He, L. and Oleksiak, A. and Zhang, Y. and Li, N. and Hu, Y. and Chen, W. and Qiu, Z. and Paeaebo, S. and Khaitovich, P.
Genome Research 22 (4): 611-622. April 2012

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
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Leukemia 26 (4): 806-813. April 2012

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
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Nature 483 (7391): 608-612. 29 March 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H. and Lechner, S.G. and Cheret, C. and Bourane, S. and Kolanczyk, M.E. and Pattyn, A. and Reuter, K. and Munier, F.L. and Carroll, P. and Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo, C. and Gangadharan, V. and Bali, K.K. and Xie, R.G. and Agarwal, N. and Kurejova, M. and Tappe-Theodor, A. and Tegeder, I. and Feil, S. and Lewin, G. and Polgar, E. and Todd, A.J. and Schlossmann, J. and Hofmann, F. and Liu, D.L. and Hu, S.J. and Feil, R. and Kuner, T. and Kuner, R.
PLoS Biology 10 (3): e1001283. 13 March 2012

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Jeworutzki, E. and Lopez-Hernandez, T. and Capdevila-Nortes, X. and Sirisi, S. and Bengtsson, L. and Montolio, M. and Zifarelli, G. and Arnedo, T. and Mueller, C.S. and Schulte, U. and Nunes, V. and Martinez, A. and Jentsch, T.J. and Gasull, X. and Pusch, M. and Estevez, R.
Neuron 73 (5): 951-961. 8 March 2012

Extrinsic notch ligand delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Napp, L.C. and Augustynik, M. and Paesler, F. and Krishnasamy, K. and Woiterski, J. and Limbourg, A. and Bauersachs, J. and Drexler, H. and Le Noble, F. and Limbourg, F.P.
Circulation Research 110 (4): 530-550. 17 February 2012

Bmp signaling exerts opposite effects on cardiac differentiation.
de Pater, E. and Ciampricotti, M. and Priller, F. and Veerkamp, J. and Strate, I. and Smith, K. and Lagendijk, A.K. and Schilling, T.F. and Herzog, W. and Abdelilah-Seyfried, S. and Hammerschmidt, M. and Bakkers, J.
Circulation Research 110 (4): 578-587. 17 February 2012

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A. and Christa, A. and Kur, E. and Lioubinski, O. and Bachmann, S. and Willnow, T.E. and Hammes, A.
Developmental Cell 22 (2): 268-278. 14 February 2012

Combined RNAi and localization for functionally dissecting long noncoding RNAs.
Chakraborty, D. and Kappei, D. and Theis, M. and Nitzsche, A. and Ding, L. and Paszkowski-Rogacz, M. and Surendranath, V. and Berger, N. and Schulz, H. and Saar, K. and Hubner, N. and Buchholz, F.
Nature Methods 9 (4): 360-362. 12 February 2012

Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss.
Baumann, M. and Giunta, C. and Krabichler, B. and Rueschendorf, F. and Zoppi, N. and Colombi, M. and Bittner, R.E. and Quijano-Roy, S. and Muntoni, F. and Cirak, S. and Schreiber, G. and Zou, Y. and Hu, Y. and Romero, N.B. and Carlier, R.Y. and Amberger, A. and Deutschmann, A. and Straub, V. and Rohrbach, M. and Steinmann, B. and Rostasy, K. and Karall, D. and Boennemann, C.G. and Zschocke, J. and Fauth, C.
American Journal of Human Genetics 90 (2): 201-216. 10 February 2012

CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
Nakamoto, N. and Ebinuma, H. and Kanai, T. and Chu, P.S. and Ono, Y. and Mikami, Y. and Ojiro, K. and Lipp, M. and Love, P.E. and Saito, H. and Hibi, T.
Gastroenterology 142 (2): 366-376. February 2012

Thalamic control of cortical states.
Poulet, J.F.A. and Fernandez, L.M.J. and Crochet, S. and Petersen, C.C.H.
Nature Neuroscience 15 (3): 370-372. 22 January 2012

Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
Nickolas, T.L. and Schmidt-Ott, K.M. and Canetta, P. and Forster, C. and Singer, E. and Sise, M. and Elger, A. and Maarouf, O. and Sola-Del Valle, D.A. and O'Rourke, M. and Sherman, E. and Lee, P. and Geara, A. and Imus, P. and Guddati, A. and Polland, A. and Rahman, W. and Elitok, S. and Malik, N. and Giglio, J. and El-Sayegh, S. and Devarajan, P. and Hebbar, S. and Saggi, S.J. and Hahn, B. and Kettritz, R. and Luft, F.C. and Barasch, J.
Journal of the American College of Cardiology 59 (3): 246-255. 17 January 2012

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
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Nature Chemical Biology 8 (1): 93-101. January 2012

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Heidenreich, M. and Lechner, S.G. and Vardanyan, V. and Wetzel, C. and Cremers, C.W. and De Leenheer, E.M. and Aranguez, G. and Moreno-Pelayo, M.A. and Jentsch, T.J. and Lewin, G.R.
Nature Neuroscience 15 (1): 138-145. 2012

The molecular basis of acid insensitivity in the African naked mole-rat.
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Science 334 (6062): 1557-1560. 16 December 2011

Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders, K. and Buschow, C. and Herrmann, A. and Milojkovic, A. and Loddenkemper, C. and Kammertoens, T. and Daniel, P. and Yu, H. and Charo, J. and Blankenstein, T.
Cancer Cell 20 (6): 755-767. 13 December 2011

In vivo and transcriptome-wide identification of RNA binding protein target sites.
Jungkamp, A.C. and Stoeckius, M. and Mecenas, D. and Gruen, D. and Mastrobuoni, G. and Kempa, S. and Rajewsky, N.
Molecular Cell 44 (5): 828-840. 9 December 2011

Luminal CD4 + T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
Nemoto, Y. and Kanai, T. and Shinohara, T. and Ito, T. and Nakamura, T. and Okamoto, R. and Tsuchiya, K. and Lipp, M. and Eishi, Y. and Watanabe, M.
Gastroenterology 141 (6): 2130-2139.e11. December 2011

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
Somel, M. and Liu, X. and Tang, L. and Yan, Z. and Hu, H. and Guo, S. and Jiang, X. and Zhang, X. and Xu, G. and Xie, G. and Li, N. and Hu, Y. and Chen, W. and Paeaebo, S. and Khaitovich, P.
PLoS Biology 9 (12): e1001214. December 2011

Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study.
Trichopoulos, D. and Bamia, C. and Lagiou, P. and Fedirko, V. and Trepo, E. and Jenab, M. and Pischon, T. and Noethlings, U. and Overved, K. and Tjonneland, A. and Outzen, M. and Clavel-Chapelon, F. and Kaaks, R. and Lukanova, A. and Boeing, H. and Aleksandrova, K. and Benetou, V. and Zylis, D. and Palli, D. and Pala, V. and Panico, S. and Tumino, R. and Sacerdote, C. and Bueno-De-Mesquita, H.B. and Van Kranen, H.J. and Peeters, P.H. and Lund, E. and Quiros, J.R. and Gonzalez, C.A. and Sanchez Perez, M.J. and Navarro, C. and Dorronsoro, M. and Barricarte, A. and Lindkvist, B. and Regner, S. and Werner, M. and Hallmans, G. and Khaw, K.T. and Wareham, N. and Key, T. and Romieu, I. and Chuang, S.C. and Murphy, N. and Boffetta, P. and Trichopoulou, A. and Riboli, E.
Journal of the National Cancer Institute 103 (22): 1686-1695. 16 November 2011

Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group.
Borchmann, P. and Haverkamp, H. and Diehl, V. and Cerny, T. and Markova, J. and Ho, A.D. and Eich, H.T. and Mueller-Hermelink, H.K. and Kanz, L. and Greil, R. and Rank, A. and Paulus, U. and Smardova, L. and Huber, C. and Doerken, B. and Nerl, C. and Krause, S.W. and Mueller, R.P. and Fuchs, M. and Engert, A.
Journal of Clinical Oncology 29 (32): 4234-4342. 10 November 2011

PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactose.
Mueller, J.J. and Weiss, M.S. and Heinemann, U.
Acta Crystallographica Section D 67 (Pt 11): 936-944. November 2011

Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function.
Gao, S. and von der Malsburg, A. and Dick, A. and Faelber, K. and Schroeder, G.F. and Haller, O. and Kochs, G. and Daumke, O.
Immunity 35 (4): 514-525. 28 October 2011

Inflammatory skin and bowel disease linked to ADAM17 deletion.
Blaydon, D.C. and Biancheri, P. and Di, W.L. and Plagnol, V. and Cabral, R.M. and Brooke, M.A. and van Heel, D.A. and Ruschendorf, F. and Toynbee, M. and Walne, A. and O'Toole, E.A. and Martin, J.E. and Lindley, K. and Vulliamy, T. and Abrams, D.J. and MacDonald, T.T. and Harper, J.I. and Kelsell, D.P.
New England Journal of Medicine 365 (16): 1502-1508. 20 October 2011

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H. and Kase, J. and Doerr, J.R. and Milanovic, M. and Lenze, D. and Grau, M. and Beuster, G. and Ji, S. and Reimann, M. and Lenz, P. and Hummel, M. and Doerken, B. and Lenz, G. and Scheidereit, C. and Schmitt, C.A. and Lee, S.
Genes & Development 25 (20): 2137-2146. 15 October 2011

Coherent phasic excitation during hippocampal ripples.
Maier, N. and Tejero-Cantero, A. and Dorrn, A.L. and Winterer, J. and Beed, P.S. and Morris, G. and Kempter, R. and Poulet, J.F.A. and Leibold, C. and Schmitz, D.
Neuron 72 (1): 137-152. 6 October 2011

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe, C. and Ye, J. and Ahmed, R. and Sun, X.M. and Serafin, A. and Ware, J. and Bottolo, L. and Muckett, P. and Canas, X. and Zhang, J. and Rowe, G.C. and Buchan, R. and Lu, H. and Braithwaite, A. and Mancini, M. and Hauton, D. and Marti, R. and Garcia-Arumi, E. and Hubner, N. and Jacob, H. and Serikawa, T. and Zidek, V. and Papousek, F. and Kolar, F. and Cardona, M. and Ruiz-Meana, M. and Garcia-Dorado, D. and Comella, J.X. and Felkin, L.E. and Barton, P.J. and Arany, Z. and Pravenec, M. and Petretto, E. and Sanchis, D. and Cook, S.A.
Nature 478 (7367): 114-118. 6 October 2011

Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Najmabadi, H. and Hu, H. and Garshasbi, M. and Zemojtel, T. and Abedini, S.S. and Chen, W. and Hosseini, M. and Behjati, F. and Haas, S. and Jamali, P. and Zecha, A. and Mohseni, M. and Puettmann, L. and Vahid, L.N. and Jensen, C. and Moheb, L.A. and Bienek, M. and Larti, F. and Mueller, I. and Weissmann, R. and Darvish, H. and Wrogemann, K. and Hadavi, V. and Lipkowitz, B. and Esmaeeli-Nieh, S. and Wieczorek, D. and Kariminejad, R. and Firouzabadi, S.G. and Cohen, M. and Fattahi, Z. and Rost, I. and Mojahedi, F. and Hertzberg, C. and Dehghan, A. and Rajab, A. and Banavandi, M.J.S. and Hoffer, J. and Falah, M. and Musante, L. and Kalscheuer, V. and Ullmann, R. and Kuss, A.W. and Tzschach, A. and Kahrizi, K. and Ropers, H.H.
Nature 478 (7367): 57-63. 6 October 2011

BCL9-2 promotes early stages of intestinal tumor progression.
Brembeck, F.H. and Wiese, M. and Zatula, N. and Grigoryan, T. and Dai, Y. and Fritzmann, J. and Birchmeier, W.
Gastroenterology 141 (4): 1359-1370. October 2011

Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Ivics, Z. and Izsvak, Z. and Medrano, G. and Chapman, K.M. and Hamra, F.K.
Nature Protocols 6 (10): 1521-1535. October 2011

Crystal structure of nucleotide-free dynamin.
Faelber, K. and Posor, Y. and Gao, S. and Held, M. and Roske, Y. and Schulze, D. and Haucke, V. and Noe, F. and Daumke, O.
Nature 477 (7366): 556-560. 29 September 2011

Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling.
Van Ho, A.T. and Hayashi, S. and Broehl, D. and Aurade, F. and Rattenbach, R. and Relaix, F.
Developmental Cell 21 (2): 273-287. 16 August 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Sawcer, S. and Hellenthal, G. and Pirinen, M. and Spencer, C.C. and Patsopoulos, N.A. and Moutsianas, L. and Dilthey, A. and Su, Z. and Freeman, C. and Hunt, S.E. and Edkins, S. and Gray, E. and Booth, D.R. and Potter, S.C. and Goris, A. and Band, G. and Oturai, A.B. and Strange, A. and Saarela, J. and Bellenguez, C. and Fontaine, B. and Gillman, M. and Hemmer, B. and Gwilliam, R. and Zipp, F. and Jayakumar, A. and Martin, R. and Leslie, S. and Hawkins, S. and Giannoulatou, E. and D'alfonso, S. and Blackburn, H. and Boneschi, F.M. and Liddle, J. and Harbo, H.F. and Perez, M.L. and Spurkland, A. and Waller, M.J. and Mycko, M.P. and Ricketts, M. and Comabella, M. and Hammond, N. and Kockum, I. and McCann, O.T. and Ban, M. and Whittaker, P. and Kemppinen, A. and Weston, P. and Hawkins, C. and Widaa, S. and Zajicek, J. and Dronov, S. and Robertson, N. and Bumpstead, S.J. and Barcellos, L.F. and Ravindrarajah, R. and Abraham, R. and Alfredsson, L. and Ardlie, K. and Aubin, C. and Baker, A. and Baker, K. and Baranzini, S.E. and Bergamaschi, L. and Bergamaschi, R. and Bernstein, A. and Berthele, A. and Boggild, M. and Bradfield, J.P. and Brassat, D. and Broadley, S.A. and Buck, D. and Butzkueven, H. and Capra, R. and Carroll, W.M. and Cavalla, P. and Celius, E.G. and Cepok, S. and Chiavacci, R. and Clerget-Darpoux, F. and Clysters, K. and Comi, G. and Cossburn, M. and Cournu-Rebeix, I. and Cox, M.B. and Cozen, W. and Cree, B.A. and Cross, A.H. and Cusi, D. and Daly, M.J. and Davis, E. and de Bakker, P.I. and Debouverie, M. and D'hooghe, M.B. and Dixon, K. and Dobosi, R. and Dubois, B. and Ellinghaus, D. and Elovaara, I. and Esposito, F. and Fontenille, C. and Foote, S. and Franke, A. and Galimberti, D. and Ghezzi, A. and Glessner, J. and Gomez, R. and Gout, O. and Graham, C. and Grant, S.F. and Guerini, F.R. and Hakonarson, H. and Hall, P. and Hamsten, A. and Hartung, H.P. and Heard, R.N. and Heath, S. and Hobart, J. and Hoshi, M. and Infante-Duarte, C. and Ingram, G. and Ingram, W. and Islam, T. and Jagodic, M. and Kabesch, M. and Kermode, A.G. and Kilpatrick, T.J. and Kim, C. and Klopp, N. and Koivisto, K. and Larsson, M. and Lathrop, M. and Lechner-Scott, J.S. and Leone, M.A. and Leppa, V. and Liljedahl, U. and Bomfim, I.L. and Lincoln, R.R. and Link, J. and Liu, J. and Lorentzen, A.R. and Lupoli, S. and Macciardi, F. and Mack, T. and Marriott, M. and Martinelli, V. and Mason, D. and McCauley, J.L. and Mentch, F. and Mero, I.L. and Mihalova, T. and Montalban, X. and Mottershead, J. and Myhr, K.M. and Naldi, P. and Ollier, W. and Page, A. and Palotie, A. and Pelletier, J. and Piccio, L. and Pickersgill, T. and Piehl, F. and Pobywajlo, S. and Quach, H.L. and Ramsay, P.P. and Reunanen, M. and Reynolds, R. and Rioux, J.D. and Rodegher, M. and Roesner, S. and Rubio, J.P. and Ruckert, I.M. and Salvetti, M. and Salvi, E. and Santaniello, A. and Schaefer, C.A. and Schreiber, S. and Schulze, C. and Scott, R.J. and Sellebjerg, F. and Selmaj, K.W. and Sexton, D. and Shen, L. and Simms-Acuna, B. and Skidmore, S. and Sleiman, P.M. and Smestad, C. and Sorensen, P.S. and Sondergaard, H.B. and Stankovich, J. and Strange, R.C. and Sulonen, A.M. and Sundqvist, E. and Syvanen, A.C. and Taddeo, F. and Taylor, B. and Blackwell, J.M. and Tienari, P. and Bramon, E. and Tourbah, A. and Brown, M.A. and Tronczynska, E. and Casas, J.P. and Tubridy, N. and Corvin, A. and Vickery, J. and Jankowski, J. and Villoslada, P. and Markus, H.S. and Wang, K. and Mathew, C.G. and Wason, J. and Palmer, C.N. and Wichmann, H.E. and Plomin, R. and Willoughby, E. and Rautanen, A. and Winkelmann, J. and Wittig, M. and Trembath, R.C. and Yaouanq, J. and Viswanathan, A.C. and Zhang, H. and Wood, N.W. and Zuvich, R. and Deloukas, P. and Langford, C. and Duncanson, A. and Oksenberg, J.R. and Pericak-Vance, M.A. and Haines, J.L. and Olsson, T. and Hillert, J. and Ivinson, A.J. and De Jager, P.L. and Peltonen, L. and Stewart, G.J. and Hafler, D.A. and Hauser, S.L. and McVean, G. and Donnelly, P. and Compston, A.
Nature 476 (7359): 214-219. 10 August 2011

Photocontrol of contracting muscle fibers.
Hoppmann, C. and Schmieder, P. and Domaing, P. and Vogelreiter, G. and Eichhorst, J. and Wiesner, B. and Morano, I. and Rueck-Braun, K. and Beyermann, M.
Angewandte Chemie International Edition 50 (33): 7699-7702. 8 August 2011

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Lebedeva, S. and Jens, M. and Theil, K. and Schwanhaeusser, B. and Selbach, M. and Landthaler, M. and Rajewsky, N.
Molecular Cell 43 (3): 340-352. 5 August 2011

Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger, A. and Moebs, M. and Ullmann, R. and Koechert, K. and Kreher, S. and Lamprecht, B. and Anagnostopoulos, I. and Hummel, M. and Richter, J. and Beyer, M. and Janz, M. and Klemke, C.D. and Stein, H. and Doerken, B. and Sterry, W. and Schrock, E. and Mathas, S. and Assaf, C.
Journal of Experimental Medicine 208 (8): 1585-1593. 1 August 2011

Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U. and Walther, W. and Scudiero, D. and Selby, M. and Kobelt, D. and Lemm, M. and Fichtner, I. and Schlag, P.M. and Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103 (13): 1018-1036. 6 July 2011

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Chiang, L.Y. and Poole, K. and Oliveira, B.E. and Duarte, N. and Bernal Sierra, Y.A. and Bruckner-Tuderman, L. and Koch, M. and Hu, J. and Lewin, G.R.
Nature Neuroscience 14 (8): 993-1000. 3 July 2011

De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C. and Wang, Y. and Gruen, D. and Mastrobuoni, G. and You, X. and Tolle, D. and Dodt, M. and Mackowiak, S.D. and Gogol-Doering, A. and Oenal, P. and Rybak, A. and Ross, E. and Alvarado, A.S. and Kempa, S. and Dieterich, C. and Rajewsky, N. and Chen, W.
Genome Research 21 (7): 1193-1200. July 2011

Ca(2+)-activated Cl(-) currents are dispensable for olfaction.
Billig, G.M. and Pal, B. and Fidzinski, P. and Jentsch, T.J.
Nature Neuroscience 14 (6): 763-769. June 2011

Lrp5 functions in bone to regulate bone mass.
Cui, Y. and Niziolek, P.J. and Macdonald, B.T. and Zylstra, C.R. and Alenina, N. and Robinson, D.R. and Zhong, Z. and Matthes, S. and Jacobsen, C.M. and Conlon, R.A. and Brommage, R. and Liu, Q. and Mseeh, F. and Powell, D.R. and Yang, Q.M. and Zambrowicz, B. and Gerrits, H. and Gossen, J.A. and He, X. and Bader, M. and Williams, B.O. and Warman, M.L. and Robling, A.G.
Nature Medicine 17 (6): 684-691. June 2011

Global quantification of mammalian gene expression control.
Schwanhaeusser, B. and Busse, D. and Li, N. and Dittmar, G. and Schuchhardt, J. and Wolf, J. and Chen, W. and Selbach, M.
Nature 473 (7347): 337-342. 19 May 2011

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K. and Pietas, A. and Radke, M.H. and Gotthardt, M.
Journal of Cell Biology 193 (4): 785-798. 16 May 2011

Enterotypes of the human gut microbiome.
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Nature 473 (7346): 174-180. 12 May 2011

Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula.
Frahm, S. and Slimak, M.A. and Ferrarese, L. and Santos-Torres, J. and Antolin-Fontes, B. and Auer, S. and Filkin, S. and Pons, S. and Fontaine, J.F. and Tsetlin, V. and Maskos, U. and Ibanez-Tallon, I.
Neuron 70 (3): 522-535. 12 May 2011

Platelet-derived serotonin links vascular disease and tissue fibrosis.
Dees, C. and Akhmetshina, A. and Zerr, P. and Reich, N. and Palumbo, K. and Horn, A. and Juengel, A. and Beyer, C. and Kroenke, G. and Zwerina, J. and Reiter, R. and Alenina, N. and Maroteaux, L. and Gay, S. and Schett, G. and Distler, O. and Distler, J.H.
Journal of Experimental Medicine 208 (5): 961-972. 9 May 2011

Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
Haufe, S. and Engeli, S. and Kast, P. and Boehnke, J. and Utz, W. and Haas, V. and Hermsdorf, M. and Maehler, A. and Wiesner, S. and Birkenfeld, A.L. and Sell, H. and Otto, C. and Mehling, H. and Luft, F.C. and Eckel, J. and Schulz-Menger, J. and Boschmann, M. and Jordan, J.
Hepatology 53 (5): 1504-1514. May 2011

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
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Journal of Clinical Investigation 121 (4): 1608-1623. 1 April 2011

Synaptic mechanisms underlying sparse coding of active touch.
Crochet, S. and Poulet, J.F.A. and Kremer, Y. and Petersen, C.C.H.
Neuron 69 (6): 1160-1175. 24 March 2011

CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia.
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American Journal of Human Genetics 88 (3): 333-343. 11 March 2011

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton, M. and Levin, A. and Slyper, M. and Alkalay, I. and Horwitz, E. and Mor, H. and Kredo-Russo, S. and Avnit-Sagi, T. and Cojocaru, G. and Zreik, F. and Bentwich, Z. and Poy, M.N. and Artis, D. and Walker, M.D. and Hornstein, E. and Pikarsky, E. and Ben-Neriah, Y.
Nature Immunology 12 (3): 239-246. March 2011

The Ngal reporter mouse detects the response of the kidney to injury in real time.
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Nature Medicine 17 (2): 216-222. February 2011

A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
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Nature Protocols 6 (3): 359-364. February 2011

The molecular and cellular identity of peripheral osmoreceptors.
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Neuron 69 (2): 332-344. 27 January 2011

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
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Nature Neuroscience 14 (1): 54-61. January 2011

Integrative analysis of the caenorhabditis elegans genome by the modENCODE project.
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Science 330 (6012): 1775-1787. 24 December 2010

An embedded subnetwork of highly active neurons in the neocortex.
Yassin, L. and Benedetti, B.L. and Jouhanneau, J.S. and Wen, J.A. and Poulet, J.F.A. and Barth, A.L.
Neuron 68 (6): 1043-1050. 22 December 2010

Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer Randomized Trial 40954.
Schuhmacher, C. and Gretschel, S. and Lordick, F. and Reichardt, P. and Hohenberger, W. and Eisenberger, C.F. and Haag, C. and Mauer, M.E. and Hasan, B. and Welch, J. and Ott, K. and Hoelscher, A. and Schneider, P.M. and Bechstein, W. and Wilke, H. and Lutz, M.P. and Nordlinger, B. and Van Cutsem, E. and Siewert, J.R. and Schlag, P.M.
Journal of Clinical Oncology 28 (35): 5210-5218. 10 December 2010

Structure of a classical MHC class I molecule that binds "non-classical" ligands.
Hee, C.S. and Gao, S. and Loll, B. and Miller, M.M. and Uchanska-Ziegler, B. and Daumke, O. and Ziegler, A.
PLoS Biology 8 (12): e1000557. 7 December 2010

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M. and Wilde, S. and Spranger, S. and Milosevic, S. and Frankenberger, B. and Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
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Nature Immunology 11 (11): 1057-1062. November 2010

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N. and Fujimoto, M. and Tan, K. and Prakasam, R. and Shinkawa, T. and Li, L. and Ichikawa, H. and Takii, R. and Nakai, A.
EMBO Journal 29 (20): 3459-3469. 20 October 2010

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Orinska, Z. and Foeger, N. and Huber, M. and Marschall, J. and Mirghomizadeh, F. and Du, X. and Scheller, M. and Rosenstiel, P. and Goldmann, T. and Bollinger, A. and Beutler, B.A. and Bulfone-Paus, S.
Blood 116 (15): 2665-2675. 14 October 2010

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz, M. and Stilmann, M. and Coel Arslan, S. and Khanna, K.K. and Dittmar, G. and Scheidereit, C.
Molecular Cell 40 (1): 63-74. 8 October 2010

Novel baroreflex activation therapy in resistant hypertension results of a European multi-center feasibility study.
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Journal of the American College of Cardiology 56 (15): 1254-1258. 5 October 2010

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V. and Radbruch, H. and Glumm, R. and Niesner, R. and Paterka, M. and Herz, J. and Leuenberger, T. and Lehmann, S.M. and Luenstedt, S. and Rinnenthal, J.L. and Laube, G. and Luche, H. and Lehnardt, S. and Fehling, H.J. and Griesbeck, O. and Zipp, F.
Immunity 33 (3): 424-436. 24 September 2010

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M. and Petretto, E. and Wallace, C. and Bottolo, L. and Rotival, M. and Lu, H. and Li, Y. and Sarwar, R. and Langley, S.R. and Bauerfeind, A. and Hummel, O. and Lee, Y.A. and Paskas, S. and Rintisch, C. and Saar, K. and Cooper, J. and Buchan, R. and Gray, E.E. and Cyster, J.G. and Braund, P. and Gracey, J. and Krishnan, U. and Moore, J.S. and Nelson, C.P. and Pollard, H. and Attwood, T. and Crisp-Hihn, A. and Foad, N. and Jolley, J. and Lloyd-Jones, H. and Muir, D. and Murray, E. and O'Leary, K. and Rankin, A. and Sambrook, J. and Godfroy, T. and Brocheton, J. and Proust, C. and Schmitz, G. and Heimerl, S. and Lugauer, I. and Belz, S. and Gulde, S. and Linsel-Nitschke, P. and Sager, H. and Schroeder, L. and Lundmark, P. and Syvannen, A.C. and Neudert, J. and Scholz, M. and Deloukas, P. and Gray, E. and Gwilliams, R. and Niblett, D. and Erdmann, J. and Hengstenberg, C. and Maouche, S. and Ouwehand, W.H. and Rice, C.M. and Samani, N.J. and Schunkert, H. and Goodall, A.H. and Schulz, H. and Roider, H.G. and Vingron, M. and Blankenberg, S. and Muenzel, T. and Zeller, T. and Szymczak, S. and Ziegler, A. and Tiret, L. and Smyth, D.J. and Pravenec, M. and Aitman, T.J. and Cambien, F. and Clayton, D. and Todd, J.A. and Huebner, N. and Cook, S.A.
Nature 467 (7314): 460-464. 23 September 2010

Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Eich, H.T. and Diehl, V. and Goergens, H. and Pabst, T. and Markova, J. and Debus, J. and Ho, A. and Doerken, B. and Rank, A. and Grosu, A.L. and Wiegel, T. and Karstens, J.H. and Greil, R. and Willich, N. and Schmidberger, H. and Doehner, H. and Borchmann, P. and Mueller-Hermelink, H.K. and Mueller, R.P. and Engert, A.
Journal of Clinical Oncology 28 (27): 4199-4206. 20 September 2010

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby, M. and Andersen, O.M. and Breiderhoff, T. and Fjorback, A.W. and Pedersen, K.M. and Madsen, P. and Jansen, P. and Heeren, J. and Willnow, T.E. and Nykjaer, A.
Cell Metabolism 12 (3): 213-223. 8 September 2010

Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P. and Lampert, J.C. and Chen, X. and Leitao, C. and Popovic, J. and Mueller, W. and Blankenstein, T.
Nature Medicine 16 (9): 1029-1034. September 2010

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
Somel, M. and Guo, S. and Fu, N. and Yan, Z. and Hu, H.Y. and Xu, Y. and Yuan, Y. and Ning, Z. and Hu, Y. and Menzel, C. and Hu, H. and Lachmann, M. and Zeng, R. and Chen, W. and Khaitovich, P.
Genome Research 20 (9): 1207-1218. September 2010

Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert, A. and Pluetschow, A. and Eich, H.T. and Lohri, A. and Doerken, B. and Borchmann, P. and Berger, B. and Greil, R. and Willborn, K.C. and Wilhelm, M. and Debus, J. and Eble, M.J. and Soekler, M. and Ho, A. and Rank, A. and Ganser, A. and Truemper, L. and Bokemeyer, C. and Kirchner, H. and Schubert, J. and Kral, Z. and Fuchs, M. and Mueller-Hermelink, H.K. and Mueller, R.P. and Diehl, V.
New England Journal of Medicine 363 (7): 640-652. 12 August 2010

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao, G. and Clifton, M. and Hoette, T.M. and Mori, K. and Deng, S.X. and Qiu, A. and Viltard, M. and Williams, D. and Paragas, N. and Leete, T. and Kulkarni, R. and Li, X. and Lee, B. and Kalandadze, A. and Ratner, A.J. and Pizarro, J.C. and Schmidt-Ott, K.M. and Landry, D.W. and Raymond, K.N. and Strong, R.K. and Barasch, J.
Nature Chemical Biology 6 (8): 602-609. August 2010

The Landscape of C. elegans 3'UTRs.
Mangone, M. and Manoharan, A.P. and Thierry-Mieg, D. and Thierry-Mieg, J. and Han, T. and Mackowiak, S. and Mis, E. and Zegar, C. and Gutwein, M.R. and Khivansara, V. and Attie, O. and Chen, K. and Salehi-Ashtiani, K. and Vidal, M. and Harkins, T.T. and Bouffard, P. and Suzuki, Y. and Sugano, S. and Kohara, Y. and Rajewsky, N. and Piano, F. and Gunsalus, K.C. and Kim, J.K.
Science 329 (5990): 432-435. 23 July 2010

Loss of fish actinotrichia proteins and the fin-to-limb transition.
Zhang, J. and Wagh, P. and Guay, D. and Sanchez-Pulido, L. and Padhi, B.K. and Korzh, V. and Andrade-Navarro, M.A. and Akimenko, M.A.
Nature 466 (7303): 234-237. 8 July 2010

Developmental sensory experience balances cortical excitation and inhibition.
Dorrn, A.L. and Yuan, K. and Barker, A.J. and Schreiner, C.E. and Froemke, R.C.
Nature 465 (7300): 932-936. 17 June 2010

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G. and Weinert, S. and Rickheit, G. and Jentsch, T.J.
Science 328 (5984): 1398-1401. 11 June 2010

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S. and Jabs, S. and Supanchart, C. and Schweizer, M. and Gimber, N. and Richter, M. and Rademann, J. and Stauber, T. and Kornak, U. and Jentsch, T.J.
Science 328 (5984): 1401-1403. 11 June 2010

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch, A. and Seitz, S. and Baschant, U. and Schilling, A.F. and Illing, A. and Stride, B. and Kirilov, M. and Mandic, V. and Takacz, A. and Schmidt-Ullrich, R. and Ostermay, S. and Schinke, T. and Spanbroek, R. and Zaiss, M.M. and Angel, P.E. and Lerner, U.H. and David, J.P. and Reichardt, H.M. and Amling, M. and Schuetz, G. and Tuckermann, J.P.
Cell Metabolism 11 (6): 517-531. 9 June 2010

Fetal growth restriction results in remodeled and less efficient hearts in children.
Crispi, F. and Bijnens, B. and Figueras, F. and Bartrons, J. and Eixarch, E. and Le Noble, F. and Ahmed, A. and Gratacos, E.
Circulation 121 (22): 2427-2436. 8 June 2010

The genome sequence of the spontaneously hypertensive rat: analysis and functional significance.
Atanur, S.S. and Birol, I. and Guryev, V. and Hirst, M. and Hummel, O. and Morrissey, C. and Behmoaras, J. and Fernandez-Suarez, X.M. and Johnson, M.D. and McLaren, W.M. and Patone, G. and Petretto, E. and Plessy, C. and Rockland, K.S. and Rockland, C. and Saar, K. and Zhao, Y. and Carninci, P. and Flicek, P. and Kurtz, T. and Cuppen, E. and Pravenec, M. and Huebner, N. and Jones, S.J. and Birney, E. and Aitman, T.J.
Genome Research 20 (6): 791-803. June 2010

Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models.
Borchert, N. and Dieterich, C. and Krug, K. and Schuetz, W. and Jung, S. and Nordheim, A. and Sommer, R.J. and Macek, B.
Genome Research 20 (6): 837-486. June 2010

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z. and Froehlich, J. and Grabundzija, I. and Shirley, J.R. and Powell, H.M. and Chapman, K.M. and Ivics, Z. and Hamra, F.K.
Nature Methods 7 (6): 443-445. June 2010

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.
Zaltsman, Y. and Shachnai, L. and Yivgi-Ohana, N. and Schwarz, M. and Maryanovich, M. and Houtkooper, R.H. and Vaz, F.M. and De Leonardis, F. and Fiermonte, G. and Palmieri, F. and Gillissen, B. and Daniel, P.T. and Jimenez, E. and Walsh, S. and Koehler, C.M. and Roy, S.S. and Walter, L. and Hajnoczky, G. and Gross, A.
Nature Cell Biology 12 (6): 553-562. June 2010

Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Gao, S. and von der Malsburg, A. and Paeschke, S. and Behlke, J. and Haller, O. and Kochs, G. and Daumke, O.
Nature 465 (7297): 502-506. 27 May 2010

Ontologies in quantitative biology: a basis for comparison, integration, and discovery.
Jensen, L.J. and Bork, P.
PLoS Biology 8 (5): e1000374. 25 May 2010

Altered histone acetylation is associated with age-dependent memory impairment in mice.
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Science 328 (5979): 753-756. 7 May 2010

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M. and Linnemann, C. and Hooijkaas, A.I. and Bies, L. and de Witte, M.A. and Jorritsma, A. and Kaiser, A.D.M. and Pouw, N. and Debets, R. and Kieback, E. and Uckert, W. and Song, J.Y. and Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16 (5): 565-570, 1p following 570. May 2010

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B. and Walter, K. and Kreher, S. and Kumar, R. and Hummel, M. and Lenze, D. and Koechert, K. and Bouhlel, M.A. and Richter, J. and Soler, E. and Stadhouders, R. and Joehrens, K. and Wurster, K.D. and Callen, D.F. and Harte, M.F. and Giefing, M. and Barlow, R. and Stein, H. and Anagnostopoulos, I. and Janz, M. and Cockerill, P.N. and Siebert, R. and Doerken, B. and Bonifer, C. and Mathas, S.
Nature Medicine 16 (5): 571-579, 1p following 579. May 2010

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Stolz, A. and Ertych, N. and Kienitz, A. and Vogel, C. and Schneider, V. and Fritz, B. and Jacob, R. and Dittmar, G. and Weichert, W. and Petersen, I. and Bastians, H.
Nature Cell Biology 12 (5): 492-499. May 2010

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E. and Pless, O. and Dittmar, G. and Knoblich, M. and Leutz, A.
EMBO Journal 29 (6): 1105-1115. 17 March 2010

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M. and Lee, S. and Loddenkemper, C. and Doerr, J.R. and Tabor, V. and Aichele, P. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17 (3): 262-272. 16 March 2010

Silencing neurotransmission with membrane-tethered toxins.
Auer, S. and Stuerzebecher, A.S. and Juettner, R. and Santos-Torres, J. and Hanack, C. and Frahm, S. and Liehl, B. and Ibanez-Tallon, I.
Nature Methods 7 (3): 229-236. March 2010

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Luber, C.A. and Cox, J. and Lauterbach, H. and Fancke, B. and Selbach, M. and Tschopp, J. and Akira, S. and Wiegand, M. and Hochrein, H. and O'Keeffe, M. and Mann, M.
Immunity 32 (2): 279-289. 26 February 2010

Evidence for a protein tether involved in somatic touch.
Hu, J. and Chiang, L.Y. and Koch, M. and Lewin, G.R.
EMBO Journal 29 (4): 855-867. 17 February 2010

Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon their potential impact for early risk assessment in asymptomatic Chagas' patients.
Wallukat, G. and Munoz Saravia, S.G. and Haberland, A. and Bartel, S. and Araujo, R. and Valda, G. and Duchen, D. and Diaz Ramirez, I. and Borges, A.C. and Schimke, I.
Journal of the American College of Cardiology 55 (5): 463-468. 2 February 2010

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A. and Monet-Lepretre, M. and Gosele, C. and Baron-Menguy, C. and Hammes, A. and Schmidt, S. and Lemaire-Carrette, B. and Domenga, V. and Schedl, A. and Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120 (2): 433-445. 1 February 2010

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K. and Begay, V. and Smink, J.J. and Zaragoza, K. and Wiesenthal, V. and Doerken, B. and Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y. and Liska, F. and Gosele, C. and Sedova, L. and Kren, V. and Krenova, D. and Ivics, Z. and Huebner, N. and Izsvak, Z.
Genome Research 20 (1): 19-27. January 2010

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C. and Hanna, J. and Hirsch, C. and Volkwein, C. and Schütz, A. and Heinemann, U. and Sommer, T. and Jarosch, E.
Molecular Cell 36 (5): 782-793. 11 December 2009

Quantitative proteomics: a tool to assess cell differentiation.
Vermeulen, M. and Selbach, M.
Current Opinion in Cell Biology 21 (6): 761-766. December 2009

Central control of fever and female body temperature by RANKL/RANK.
Hanada, R. and Leibbrandt, A. and Hanada, T. and Kitaoka, S. and Furuyashiki, T. and Fujihara, H. and Trichereau, J. and Paolino, M. and Qadri, F. and Plehm, R. and Klaere, S. and Komnenovic, V. and Mimata, H. and Yoshimatsu, H. and Takahashi, N. and von Haeseler, A. and Bader, M. and Kilic, S.S. and Ueta, Y. and Pifl, C. and Narumiya, S. and Penninger, J.M.
Nature 462 (7272): 505-509. 26 November 2009

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M. and Hinz, M. and Coel Arslan, S. and Zimmer, A. and Schreiber, V. and Scheidereit, C.
Molecular Cell 36 (3): 365-378. 13 November 2009

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M. and Vockentanz, L. and Kharazi, S. and Huska, M.R. and Mancini, E. and Scheller, M. and Kuhl, C. and Enns, A. and Prinz, M. and Jaenisch, R. and Nerlov, C. and Leutz, A. and Andrade-Navarro, M.A. and Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41 (11): 1207-1215. November 2009

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A. and Olivier, B.J. and Goverse, G. and Vondenhoff, M.F. and Greuter, M. and Beke, P. and Kusser, K. and Hoepken, U.E. and Lipp, M. and Niederreither, K. and Blomhoff, R. and Sitnik, K. and Agace, W.W. and Randall, T.D. and de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10 (11): 1193-1199. November 2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R. and Janz, M. and Galson, D.L. and Gries, M. and Li, S. and Johrens, K. and Anagnostopoulos, I. and Doerken, B. and Mapara, M.Y. and Borghesi, L. and Kardava, L. and Roodman, G.D. and Milcarek, C. and Lentzsch, S.
Blood 114 (18): 3890-3898. 29 October 2009

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Paulmann, N. and Grohmann, M. and Voigt, J.P. and Bert, B. and Vowinckel, J. and Bader, M. and Skelin, M. and Jevsek, M. and Fink, H. and Rupnik, M. and Walther, D.J.
PLoS Biology 7 (10): e1000229. 27 October 2009

Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
Adameyko, I. and Lallemend, F. and Aquino, J.B. and Pereira, J.A. and Topilko, P. and Mueller, T. and Fritz, N. and Beljajeva, A. and Mochii, M. and Liste, I. and Usoskin, D. and Suter, U. and Birchmeier, C. and Ernfors, P.
Cell 139 (2): 366-379. 16 October 2009

Ageing-related chromatin defects through loss of the NURD complex.
Pegoraro, G. and Kubben, N. and Wickert, U. and Goehler, H. and Hoffmann, K. and Misteli, T.
Nature Cell Biology 11 (10): 1261-1267. October 2009

Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius, M. and Maaskola, J. and Colombo, T. and Rahn, H.P. and Friedlaender, M.R. and Li, N. and Chen, W. and Piano, F. and Rajewsky, N.
Nature Methods 6 (10): 745-751. October 2009

Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Engert, A. and Diehl, V. and Franklin, J. and Lohri, A. and Doerken, B. and Ludwig, W.D. and Koch, P. and Haenel, M. and Pfreundschuh, M. and Wilhelm, M. and Truemper, L. and Aulitzky, W.E. and Bentz, M. and Rummel, M. and Sezer, O. and Mueller-Hermelink, H.K. and Hasenclever, D. and Loeffler, M.
Journal of Clinical Oncology 27 (27): 4548-4554. 20 September 2009

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T. and Beed, P. and Vogt, J. and Schuchmann, S. and Maier, N. and Kintscher, M. and Breustedt, J. and Schuelke, M. and Streu, N. and Kieselmann, O. and Brunk, I. and Laube, G. and Strauss, U. and Battefeld, A. and Wende, H. and Birchmeier, C. and Wiese, S. and Sendtner, M. and Kawabe, H. and Kishimoto-Suga, M. and Brose, N. and Baumgart, J. and Geist, B. and Aoki, J. and Savaskan, N.E. and Braeuer, A.U. and Chun, J. and Ninnemann, O. and Schmitz, D. and Nitsch, R.
Cell 138 (6): 1222-12235. 18 September 2009

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.
Wilde, S. and Sommermeyer, D. and Frankenberger, B. and Schiemann, M. and Milosevic, S. and Spranger, S. and Pohla, H. and Uckert, W. and Busch, D.H. and Schendel, D.J.
Blood 114 (10): 2131-2139. 3 September 2009

Ribosomal protein S7 is both a regulator and a substrate of MDM2.
Zhu, Y. and Poyurovsky, M.V. and Li, Y. and Biderman, L. and Stahl, J. and Jacq, X. and Prives, C.
Molecular Cell 35 (3): 316-326. 14 August 2009

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X. and Huang, X. and Nodland, S.E. and Mates, L. and Ma, L. and Izsvak, Z. and Ivics, Z. and Lebien, T.W. and McIvor, R.S. and Wagner, J.E. and Zhou, X.
Blood 114 (7): 1319-1330. 13 August 2009

PET imaging of leptin biodistribution and metabolism in rodents and primates.
Ceccarini, G. and Flavell, R.R. and Butelman, E.R. and Synan, M. and Willnow, T.E. and Bar-Dagan, M. and Goldsmith, S.J. and Kreek, M.J. and Kothari, P. and Vallabhajosula, S. and Muir, T.W. and Friedman, J.M.
Cell Metabolism 10 (2): 148-159. 6 August 2009

Mitochondrial vesicles: an ancient process providing new links to peroxisomes.
Andrade-Navarro, M.A. and Sanchez-Pulido, L. and McBride, H.M.
Current Opinion in Cell Biology 21 (4): 560-567. August 2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Hoepken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Doerken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y. and Tomann, P. and Andl, T. and Gallant, N.M. and Huelsken, J. and Jerchow, B. and Birchmeier, W. and Paus, R. and Piccolo, S. and Mikkola, M.L. and Morrisey, E.E. and Overbeek, P.A. and Scheidereit, C. and Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17 (1): 49-61. 21 July 2009

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J. and Morkel, M. and Besser, D. and Budczies, J. and Kosel, F. and Brembeck, F.H. and Stein, U. and Fichtner, I. and Schlag, P.M. and Birchmeier, W.
Gastroenterology 137 (11): 165-175. July 2009

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice.
Giebeler, A. and Boekschoten, M.V. and Klein, C. and Borowiak, M. and Birchmeier, C. and Gassler, N. and Wasmuth, H.E. and Mueller, M. and Trautwein, C. and Streetz, K.L.
Gastroenterology 137 (1): 297-308. July 2009

RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Henneke, M. and Diekmann, S. and Ohlenbusch, A. and Kaiser, J. and Engelbrecht, V. and Kohlschuetter, A. and Kraetzner, R. and Madruga-Garrido, M. and Mayer, M. and Opitz, L. and Rodriguez, D. and Rueschendorf, F. and Schumacher, J. and Thiele, H. and Thoms, S. and Steinfeld, R. and Nuernberg, P. and Gaertner, J.
Nature Genetics 41 (7): 773-775. July 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U. and Prat, A. and Prozorovski, T. and Siffrin, V. and Paterka, M. and Herz, J. and Bendix, I. and Ifergan, I. and Schadock, I. and Mori, M.A. and Van Horssen, J. and Schroeter, F. and Smorodchenko, A. and Han, M.H. and Bader, M. and Steinman, L. and Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Buonamici, S. and Trimarchi, T. and Ruocco, M.G. and Reavie, L. and Cathelin, S. and Mar, B.G. and Klinakis, A. and Lukyanov, Y. and Tseng, J.C. and Sen, F. and Gehrie, E. and Li, M. and Newcomb, E. and Zavadil, J. and Meruelo, D. and Lipp, M. and Ibrahim, S. and Efstratiadis, A. and Zagzag, D. and Bromberg, J.S. and Dustin, M.L. and Aifantis, I.
Nature 459 (7249): 1000-1004. 18 June 2009

Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H. and Kleinewietfeld, M. and Qadri, F. and Park, J.K. and Fischer, R. and Schwarz, I. and Rahn, H.P. and Plehm, R. and Wellner, M. and Elitok, S. and Gratze, P. and Dechend, R. and Luft, F.C. and Mueller, D.N.
Circulation 119 (22): 2904-2912. 9 June 2009

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L. and Chuah, M.K. and Belay, E. and Jerchow, B. and Manoj, N. and Acosta-Sanchez, A. and Grzela, D.P. and Schmitt, A. and Becker, K. and Matrai, J. and Ma, L. and Samara-Kuko, E. and Gysemans, C. and Pryputniewicz, D. and Miskey, C. and Fletcher, B. and Vandendriessche, T. and Ivics, Z. and Izsvak, Z.
Nature Genetics 41 (6): 753-761. June 2009

A xenon-129 biosensor for monitoring MHC-peptide interactions.
Schlundt, A. and Kilian, W. and Beyermann, M. and Sticht, J. and Guenther, S. and Hoepner, S. and Falk, K. and Roetzschke, O. and Mitschang, L. and Freund, C.
Angewandte Chemie International Edition in English 48 (23): 4142-4145. 25 May 2009

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Ding, L. and Paszkowski-Rogacz, M. and Nitzsche, A. and Slabicki, M.M. and Heninger, A.K. and Vries, I.D. and Kittler, R. and Junqueira, M. and Shevchenko, A. and Schulz, H. and Huebner, N. and Doss, M.X. and Sachinidis, A. and Hescheler, J. and Iacone, R. and Anastassiadis, K. and Stewart, A.F. and Pisabarro, M.T. and Caldarelli, A. and Poser, I. and Theis, M. and Buchholz, F.
Cell Stem Cell 4 (5): 403-415. 8 May 2009

A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo, J. and Weidinger, S. and Foelster-Holst, R. and Bauerfeind, A. and Rueschendorf, F. and Patone, G. and Rohde, K. and Marenholz, I. and Schulz, F. and Kerscher, T. and Huebner, N. and Wahn, U. and Schreiber, S. and Franke, A. and Vogler, R. and Heath, S. and Baurecht, H. and Novak, N. and Rodriguez, E. and Illig, T. and Lee-Kirsch, M.A. and Ciechanowicz, A. and Kurek, M. and Piskackova, T. and Macek, M. and Lee, Y.A. and Ruether, A.
Nature Genetics 41 (5): 596-601. May 2009

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.
Huck, K. and Feyen, O. and Niehues, T. and Rueschendorf, F. and Huebner, N. and Laws, H.J. and Telieps, T. and Knapp, S. and Wacker, H.H. and Meindl, A. and Jumaa, H. and Borkhardt, A.
Journal of Clinical Investigation 119 (5): 1350-1358. May 2009

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik, A. and Neuhofer, W. and Jantsch, J. and Dahlmann, A. and Tammela, T. and Machura, K. and Park, J.K. and Beck, F.X. and Mueller, D.N. and Derer, W. and Goss, J. and Ziomber, A. and Dietsch, P. and Wagner, H. and van Rooijen, N. and Kurtz, A. and Hilgers, K.F. and Alitalo, K. and Eckardt, K.U. and Luft, F.C. and Kerjaschki, D. and Titze, J.
Nature Medicine 15 (5): 545-552. May 2009

Host cell interactome of tyrosine-phosphorylated bacterial proteins.
Selbach, M. and Paul, F.E. and Brandt, S. and Guye, P. and Daumke, O. and Backert, S. and Dehio, C. and Mann, M.
Cell Host & Microbe 5 (4): 397-403. 23 April 2009

Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y. and Chen, C. and Lisewski, U. and Wrackmeyer, U. and Radke, M. and Westermann, D. and Sauter, M. and Tschoepe, C. and Poller, W. and Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53 (14): 1219-1226. 7 April 2009

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Taufiq-Ur-Rahman, and Skupin, A. and Falcke, M. and Taylor, C.W.
Nature 458 (7238): 655-659. 2 April 2009

Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
Heinz-Erian, P. and Mueller, T. and Krabichler, B. and Schranz, M. and Becker, C. and Rueschendorf, F. and Nuernberg, P. and Rossier, B. and Vujic, M. and Booth, I.W. and Holmberg, C. and Wijmenga, C. and Grigelioniene, G. and Kneepkens, C.M. and Rosipal, S. and Mistrik, M. and Kappler, M. and Michaud, L. and Doczy, L.C. and Siu, V.M. and Krantz, M. and Zoller, H. and Utermann, G. and Janecke, A.R.
American Journal of Human Genetics 84 (2): 188-196. 13 February 2009

BK channels in innate immune functions of neutrophils and macrophages.
Essin, K. and Gollasch, M. and Rolle, S. and Weissgerber, P. and Sausbier, M. and Bohn, E. and Autenrieth, I.B. and Ruth, P. and Luft, F.C. and Nauseef, W.M. and Kettritz, R.
Blood 113 (6): 1326-1331. 5 February 2009

15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig, I. and Mefford, H.C. and Sharp, A.J. and Guipponi, M. and Fichera, M. and Franke, A. and Muhle, H. and de Kovel, C. and Baker, C. and von Spiczak, S. and Kron, K.L. and Steinich, I. and Kleefuss-Lie, A.A. and Leu, C. and Gaus, V. and Schmitz, B. and Klein, K.M. and Reif, P.S. and Rosenow, F. and Weber, Y. and Lerche, H. and Zimprich, F. and Urak, L. and Fuchs, K. and Feucht, M. and Genton, P. and Thomas, P. and Visscher, F. and de Haan, G.J. and Moller, R.S. and Hjalgrim, H. and Luciano, D. and Wittig, M. and Nothnagel, M. and Elger, C.E. and Nuernberg, P. and Romano, C. and Malafosse, A. and Koeleman, B.P.C. and Lindhout, D. and Stephani, U. and Schreiber, S. and Eichler, E.E. and Sander, T.
Nature Genetics 41 (2): 160-162. February 2009

CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells.
Kleinewietfeld, M. and Starke, M. and Mitri, D.D. and Borsellino, G. and Battistini, L. and Roetzschke, O. and Falk, K.
Blood 113 (4): 827-836. 22 January 2009

Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Li, J.Y. and Paragas, N. and Ned, R.M. and Qiu, A. and Viltard, M. and Leete, T. and Drexler, I.R. and Chen, X. and Sanna-Cherchi, S. and Mohammed, F. and Williams, D. and Lin, C.S. and Schmidt-Ott, K.M. and Andrews, N.C. and Barasch, J.
Developmental Cell 16 (1): 35-46. 20 January 2009

Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling.
Rudolph, A. and Abdel-Aty, H. and Bohl, S. and Boye, P. and Zagrosek, A. and Dietz, R. and Schulz-Menger, J.
Journal of the American College of Cardiology 53 (3): 284-291. 20 January 2009

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. and Walther, W. and Arlt, F. and Schwabe, H. and Smith, J. and Fichtner, I. and Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

An empirical framework for binary interactome mapping.
Venkatesan, K. and Rual, J.F. and Vazquez, A. and Stelzl, U. and Lemmens, I. and Hirozane-Kishikawa, T. and Hao, T. and Zenkner, M. and Xin, X. and Goh, K.I. and Yildirim, M.A. and Simonis, N. and Heinzmann, K. and Gebreab, F. and Sahalie, J.M. and Cevik, S. and Simon, C. and de Smet, A.S. and Dann, E. and Smolyar, A. and Vinayagam, A. and Yu, H. and Szeto, D. and Borick, H. and Dricot, A. and Klitgord, N. and Murray, R.R. and Lin, C. and Lalowski, M. and Timm, J. and Rau, K. and Boone, C. and Braun, P. and Cusick, M.E. and Roth, F.P. and Hill, D.E. and Tavernier, J. and Wanker, E.E. and Barabasi, A.L. and Vidal, M.
Nature Methods 6 (1): 83-90. January 2009

PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.
Decker, E. and Stellzig-Eisenhauer, A. and Fiebig, B.S. and Rau, C. and Kress, W. and Saar, K. and Rueschendorf, F. and Huebner, N. and Grimm, T. and Weber, B.H.
American Journal of Human Genetics 83 (6): 781-786. 12 December 2008

A human snoRNA with microRNA-like functions.
Ender, C. and Krek, A. and Friedlaender, M.R. and Beitzinger, M. and Weinmann, L. and Chen, W. and Pfeffer, S. and Rajewsky, N. and Meister, G.
Molecular Cell 32 (4): 519-528. 21 November 2008

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B. and Kreher, S. and Anagnostopoulos, I. and Joehrens, K. and Monteleone, G. and Jundt, F. and Stein, H. and Janz, M. and Doerken, B. and Mathas, S.
Blood 112 (8): 3339-3347. 15 October 2008

Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
Drenckhahn, J.D. and Schwarz, Q.P. and Gray, S. and Laskowski, A. and Kiriazis, H. and Ming, Z. and Harvey, R.P. and Du, X.J. and Thorburn, D.R. and Cox, T.C.
Developmental Cell 15 (4): 521-533. 14 October 2008

Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex.
Farkas, L.M. and Haffner, C. and Giger, T. and Khaitovich, P. and Nowick, K. and Birchmeier, C. and Paeaebo, S. and Huttner, W.B.
Neuron 60 (1): 40-55. 9 October 2008

A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults.
Gotthardt, D. and Runz, H. and Keitel, V. and Fischer, C. and Flechtenmacher, C. and Wirtenberger, M. and Weiss, K.H. and Imparato, S. and Braun, A. and Hemminki, K. and Stremmel, W. and Rueschendorf, F. and Stiehl, A. and Kubitz, R. and Burwinkel, B. and Schirmacher, P. and Knisely, A.S. and Zschocke, J. and Sauer, P.
Hepatology 48 (4): 1157-1166. October 2008

Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Xi, L. and Das, A. and Zhao, Z.Q. and Merino, V.F. and Bader, M. and Kukreja, R.C.
Circulation 118 (14 Suppl): S32-S37. 30 September 2008

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U. and Shi, Y. and Wrackmeyer, U. and Fischer, R. and Chen, C. and Schirdewan, A. and Juettner, R. and Rathjen, F.G. and Poller, W. and Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205 (10): 2369-2379. 29 September 2008

Widespread changes in protein synthesis induced by microRNAs.
Selbach, M. and Schwanhaeusser, B. and Thierfelder, N. and Fang, Z. and Khanin, R. and Rajewsky, N.
Nature 455 (7209): 58-63. 4 September 2008

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Lange, M. and Kaynak, B. and Foerster, U.B. and Toenjes, M. and Fischer, J.J. and Grimm, C. and Schlesinger, J. and Just, S. and Dunkel, I. and Krueger, T. and Mebus, S. and Lehrach, H. and Lurz, R. and Gobom, J. and Rottbauer, W. and Abdelilah-Seyfried, S. and Sperling, S.
Genes & Development 22 (17): 2370-2384. 1 September 2008

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brinkmann, B.G. and Agarwal, A. and Sereda, M.W. and Garratt, A.N. and Mueller, T. and Wende, H. and Stassart, R.M. and Nawaz, S. and Humml, C. and Velanac, V. and Radyushkin, K. and Goebbels, S. and Fischer, T.M. and Franklin, R.J. and Lai, C. and Ehrenreich, H. and Birchmeier, C. and Schwab, M.H. and Nave, K.A.
Neuron 59 (4): 581-595. 28 August 2008

Autoregulation of Th1-mediated inflammation by twist1.
Niesner, U. and Albrecht, I. and Janke, M. and Doebis, C. and Loddenkemper, C. and Lexberg, M.H. and Eulenburg, K. and Kreher, S. and Koeck, J. and Baumgrass, R. and Bonhagen, K. and Kamradt, T. and Enghard, P. and Humrich, J.Y. and Rutz, S. and Schulze-Topphoff, U. and Aktas, O. and Bartfeld, S. and Radbruch, H. and Hegazy, A.N. and Lohning, M. and Baumgart, D.C. and Duchmann, R. and Rudwaleit, M. and Haupl, T. and Gitelman, I. and Krenn, V. and Gruen, J. and Sieper, J. and Zeitz, M. and Wiedenmann, B. and Zipp, F. and Hamann, A. and Janitz, M. and Scheffold, A. and Burmester, G.R. and Chang, H.D. and Radbruch, A.
Journal of Experimental Medicine 205 (8): 1889-1901. 4 August 2008

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Ebralidze, A.K. and Guibal, F.C. and Steidl, U. and Zhang, P. and Lee, S. and Bartholdy, B. and Jorda, M.A. and Petkova, V. and Rosenbauer, F. and Huang, G. and Dayaram, T. and Klupp, J. and O'Brien, K.B. and Will, B. and Hoogenkamp, M. and Borden, K.L. and Bonifer, C. and Tenen, D.G.
Genes & Development 22 (15): 2085-2092. 1 August 2008

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
Pravenec, M. and Churchill, P.C. and Churchill, M.C. and Viklicky, O. and Kazdova, L. and Aitman, T.J. and Petretto, E. and Huebner, N. and Wallace, C.A. and Zimdahl, H. and Zidek, V. and Landa, V. and Dunbar, J. and Bidani, A. and Griffin, K. and Qi, N. and Maxova, M. and Kren, V. and Mlejnek, P. and Wang, J. and Kurtz, T.W.
Nature Genetics 40 (8): 952-954. August 2008

Drug target identification using side-effect similarity.
Campillos, M. and Kuhn, M. and Gavin, A.C. and Jensen, L.J. and Bork, P.
Science 321 (5886): 263-266. 11 July 2008

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky, G. and Czeh, M. and Loddenkemper, C. and Gellermann, J. and Schmidt, K. and Wust, P. and Stein, H. and Blankenstein, T.
Journal of Experimental Medicine 205 (7): 1687-1700. 7 July 2008

Aggravation of viral hepatitis by platelet-derived serotonin.
Lang, P.A. and Contaldo, C. and Georgiev, P. and El-Badry, A.M. and Recher, M. and Kurrer, M. and Cervantes-Barragan, L. and Ludewig, B. and Calzascia, T. and Bolinger, B. and Merkler, D. and Odermatt, B. and Bader, M. and Graf, R. and Clavien, P.A. and Hegazy, A.N. and Loehning, M. and Harris, N.L. and Ohashi, P.S. and Hengartner, H. and Zinkernagel, R.M. and Lang, K.S.
Nature Medicine 14 (7): 756-761. July 2008

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L. and Carlton, P.M. and Haase, S. and Shao, L. and Winoto, L. and Kner, P. and Burke, B. and Cardoso, M.C. and Agard, D.A. and Gustafsson, M.G. and Leonhardt, H. and Sedat, J.W.
Science 320 (5881): 1332-1336. 6 June 2008

Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
Dempsie, Y. and Morecroft, I. and Welsh, D.J. and Macritchie, N.A. and Herold, N. and Loughlin, L. and Nilsen, M. and Peacock, A.J. and Harmar, A. and Bader, M. and Maclean, M.R.
Circulation 2008 (117): 2928-2937. 3 June 2008

Mutations in sarcomere protein genes in left ventricular noncompaction.
Klaassen, S. and Probst, S. and Oechslin, E. and Gerull, B. and Krings, G. and Schuler, P. and Greutmann, M. and Huerlimann, D. and Yegitbasi, M. and Pons, L. and Gramlich, M. and Drenckhahn, J.D. and Heuser, A. and Berger, F. and Jenni, R. and Thierfelder, L.
Circulation 117 (22): 2893-2901. 3 June 2008

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer, D.E. and Bieschke, J. and Boeddrich, A. and Herbst, M. and Masino, L. and Lurz, R. and Engemann, S. and Pastore, A. and Wanker, E.E.
Nature Structural & Molecular Biology 15 (6): 558-566. June 2008

Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
Gratze, P. and Dechend, R. and Stocker, C. and Park, J.K. and Feldt, S. and Shagdarsuren, E. and Wellner, M. and Gueler, F. and Rong, S. and Gross, V. and Obst, M. and Plehm, R. and Alenina, N. and Zenclussen, A. and Titze, J. and Small, K. and Yokota, Y. and Zenke, M. and Luft, F.C. and Mueller, D.N.
Circulation 117 (20): 2645-2656. 20 May 2008

Progress and prospects in rat genetics: a community view.
Aitman, T.J. and Critser, J.K. and Cuppen, E. and Dominiczak, A. and Fernandez-Suarez, X.M. and Flint, J. and Gauguier, D. and Geurts, A.M. and Gould, M. and Harris, P.C. and Holmdahl, R. and Huebner, N. and Izsvak, Z. and Jacob, H.J. and Kuramoto, T. and Kwitek, A.E. and Marrone, A. and Mashimo, T. and Moreno, C. and Mullins, J. and Mullins, L. and Olsson, T. and Pravenec, M. and Riley, L. and Saar, K. and Serikawa, T. and Shull, J.D. and Szpirer, C. and Twigger, S.N. and Voigt, B. and Worley, K.C.
Nature Genetics 40 (5): 516-22. May 2008

Distribution and functional impact of DNA copy number variation in the rat.
Guryev, V. and Saar, K. and Adamovic, T. and Verheul, M. and van Heesch, S. and Cook, S. and Pravenec, M. and Aitman, T. and Jacob, H. and Shull, J.D. and Huebner, N. and Cuppen, E.
Nature Genetics 40 (5): 538-545. May 2008

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J. and Fischer, J. and Paskas, S. and Heinig, M. and Schulz, H. and Goesele, C. and Heuser, A. and Fischer, R. and Schmidt, C. and Schirdewan, A. and Gross, V. and Hummel, O. and Maatz, H. and Patone, G. and Saar, K. and Vingron, M. and Weldon, S.M. and Lindpaintner, K. and Hammock, B.D. and Rohde, K. and Dietz, R. and Cook, S.A. and Schunck, W.H. and Luft, F.C. and Huebner, N.
Nature Genetics 40 (5): 529-537. May 2008

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
Petretto, E. and Sarwar, R. and Grieve, I. and Lu, H. and Kumaran, M.K. and Muckett, P.J. and Mangion, J. and Schroen, B. and Benson, M. and Punjabi, P.P. and Prasad, S.K. and Pennell, D.J. and Kiesewetter, C. and Tasheva, E.S. and Corpuz, L.M. and Webb, M.D. and Conrad, G.W. and Kurtz, T.W. and Kren, V. and Fischer, J. and Huebner, N. and Pinto, Y.M. and Pravenec, M. and Aitman, T.J. and Cook, S.A.
Nature Genetics 40 (5): 546-552. May 2008

SNP and haplotype mapping for genetic analysis in the rat.
Saar, K. and Beck, A. and Bihoreau, M.T. and Birney, E. and Brocklebank, D. and Chen, Y. and Cuppen, E. and Demonchy, S. and Dopazo, J. and Flicek, P. and Foglio, M. and Fujiyama, A. and Gut, I.G. and Gauguier, D. and Guigo, R. and Guryev, V. and Heinig, M. and Hummel, O. and Jahn, N. and Klages, S. and Kren, V. and Kube, M. and Kuhl, H. and Kuramoto, T. and Kuroki, Y. and Lechner, D. and Lee, Y.A. and Lopez-Bigas, N. and Lathrop, G.M. and Mashimo, T. and Medina, I. and Mott, R. and Patone, G. and Perrier-Cornet, J.A. and Platzer, M. and Pravenec, M. and Reinhardt, R. and Sakaki, Y. and Schilhabel, M. and Schulz, H. and Serikawa, T. and Shikhagaie, M. and Tatsumoto, S. and Taudien, S. and Toyoda, A. and Voigt, B. and Zelenika, D. and Zimdahl, H. and Huebner, N.
Nature Genetics 40 (5): 560-566. May 2008

The genome of the model beetle and pest tribolium castaneum.

Nature 452 (7190): 949-955. 24 April 2008

The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance.
Friedrich, M.G. and Abdel-Aty, H. and Taylor, A.J. and Schulz-Menger, J. and Messroghli, D. and Dietz, R.
Journal of the American College of Cardiology 51 (16): 1581-1587. 22 April 2008

Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene.
Merner, N.D. and Hodgkinson, K.A. and Haywood, A.F. and Connors, S. and French, V.M. and Drenckhahn, J.D. and Kupprion, C. and Ramadanova, K. and Thierfelder, L. and McKenna, W. and Gallagher, B. and Morris-Larkin, L. and Bassett, A.S. and Parfrey, P.S. and Young, T.L.
American Journal of Human Genetics 82 (4): 809-821. 11 April 2008

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I. and Peinado, H. and Kassen, D. and Hussenet, T. and Metzger, D. and Chambon, P. and Huber, M. and Hohl, D. and Cano, A. and Birchmeier, W. and Huelsken, J.
Nature 452 (7187): 650-653. 3 April 2008

Treatment-resistant chronic headaches and focal pachymeningitis in a 46-year-old man: a rare presentation of Wegener's granulomatosis.
Doerr, J. and Elitok, S. and Dieste, F.J. and Vogel, H.P. and Schneider, W. and Wuerfel, J. and Zipp, F. and Paul, F.
Lancet Neurology 7 (4): 368-372. April 2008

Discovering microRNAs from deep sequencing data using miRDeep.
Friedlaender, M.R. and Chen, W. and Adamidi, C. and Maaskola, J. and Einspanier, R. and Knespel, S. and Rajewsky, N.
Nature Biotechnology 26 (4): 407-415. April 2008

Sirt1 contributes critically to the redox-dependent fate of neural progenitors.
Prozorovski, T. and Schulze-Topphoff, U. and Glumm, R. and Baumgart, J. and Schroeter, F. and Ninnemann, O. and Siegert, E. and Bendix, I. and Bruestle, O. and Nitsch, R. and Zipp, F. and Aktas, O.
Nature Cell Biology 10 (4): 385-394. April 2008

Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.
Nordlinger, B. and Sorbye, H. and Glimelius, B. and Poston, G.J. and Schlag, P.M. and Rougier, P. and Bechstein, W.O. and Primrose, J.N. and Walpole, E.T. and Finch-Jones, M. and Jaeck, D. and Mirza, D. and Parks, R.W. and Collette, L. and Praet, M. and Bethe, U. and Van Cutsem, E. and Scheithauer, W. and Gruenberger, T.
Lancet 371 (9617): 1007-1016. 22 March 2008

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Koralov, S.B. and Muljo, S.A. and Galler, G.R. and Krek, A. and Chakraborty, T. and Kanellopoulou, C. and Jensen, K. and Cobb, B.S. and Merkenschlager, M. and Rajewsky, N. and Rajewsky, K.
Cell 132 (5): 860-874. 7 March 2008

Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Hauck, L. and Harms, C. and An, J. and Rohne, J. and Gertz, K. and Endres, M. and Dietz, R. and von Harsdorf, R.
Nature Medicine 14 (3): 315-324. March 2008

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Pasternack, S.M. and von Kuegelgen, I. and Aboud, K.A. and Lee, Y.A. and Rueschendorf, F. and Voss, K. and Hillmer, A.M. and Molderings, G.J. and Franz, T. and Ramirez, A. and Nuernberg, P. and Noethen, M.M. and Betz, R.C.
Nature Genetics 40 (3): 329-334. March 2008

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J. and Lu, Y. and Juettner, R. and Smith, E.S.J. and Hu, J. and Brand, A. and Wetzel, C. and Milenkovic, N. and Erdmann, B. and Heppenstall, P.A. and Laurito, C.E. and Wilson, S.P. and Lewin, G.R.
PLoS Biology 6 (1): e13. 29 January 2008

Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.
Neuspiel, M. and Schauss, A.C. and Braschi, E. and Zunino, R. and Rippstein, P. and Rachubinski, R.A. and Andrade-Navarro, M.A. and McBride, H.M.
Current Biology 18 (2): 102-108. 22 January 2008

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori, K. and Cholewa-Waclaw, J. and Nakada, Y. and Glasgow, S.M. and Masui, T. and Henke, R.M. and Wildner, H. and Martarelli, B. and Beres, T.M. and Epstein, J.A. and Magnuson, M.A. and Macdonald, R.J. and Birchmeier, C. and Johnson, J.E.
Genes & Development 22 (2): 166-178. 15 January 2008

Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians.
Kayser, M. and Lao, O. and Saar, K. and Brauer, S. and Wang, X. and Nuernberg, P. and Trent, R.J. and Stoneking, M.
American Journal of Human Genetics 82 (1): 194-198. 10 January 2008

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G. and Scheller, M. and Scarpellino, L. and Duboux, S. and Gardiol, N. and Back, J. and Kuttler, F. and Malanchi, I. and Birchmeier, W. and Leutz, A. and Huelsken, J. and Held, W.
Blood 111 (1): 142-149. 1 January 2008

Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis.
Matus, S. and Burgos, P.V. and Bravo-Zehnder, M. and Kraft, R. and Porras, O.H. and Farias, P. and Barros, L.F. and Torrealba, F. and Massardo, L. and Jacobelli, S. and Gonzalez, A.
Journal of Experimental Medicine 204 (13): 3221-3234. 24 December 2007

Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N. and Frahm, C. and Gassmann, M. and Griffel, C. and Erdmann, B. and Birchmeier, C. and Lewin, G.R. and Garratt, A.N.
Neuron 56 (5): 893-906. 6 December 2007

Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
Rose, C. and Ytrebo, L.M. and Davies, N.A. and Sen, S. and Nedredal, G.I. and Belanger, M. and Revhaug, A. and Jalan, R.
Hepatology 46 (6): 1883-1892. December 2007

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Bouchard, C. and Lee, S. and Paulus-Hock, V. and Loddenkemper, C. and Eilers, M. and Schmitt, C.A.
Genes & Development 21 (21): 2775-2787. 1 November 2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P. and Giehl, K. and Nyengaard, J.R. and Teng, K. and Lioubinski, O. and Sjoegaard, S.S. and Breiderhoff, T. and Gotthardt, M. and Lin, F. and Eilers, A. and Petersen, C.M. and Lewin, G.R. and Hempstead, B.L. and Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

Helicobacter exploits integrin for type IV secretion and kinase activation.
Kwok, T. and Zabler, D. and Urman, S. and Rohde, M. and Hartig, R. and Wessler, S. and Misselwitz, R. and Berger, J.M. and Sewald, N. and Koenig, W. and Backert, S.
Nature 449 (7164): 862-866. 18 October 2007

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann, M. and Loddenkemper, C. and Rudolph, C. and Schildhauer, I. and Teichmann, B. and Stein, H. and Schlegelberger, B. and Doerken, B. and Schmitt, C.A.
Blood 110 (8): 2996-3004. 15 October 2007

Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
Daumke, O. and Lundmark, R. and Vallis, Y. and Martens, S. and Butler, P.J.G. and McMahon, H.T.
Nature 449 (7164): 923-927. 3 October 2007

Association and linkage of allelic variants of the dopamine transporter gene in ADHD.
Friedel, S. and Saar, K. and Sauer, S. and Dempfle, A. and Walitza, S. and Renner, T. and Romanos, M. and Freitag, C. and Seitz, C. and Palmason, H. and Scherag, A. and Windemuth-Kieselbach, C. and Schimmelmann, B.G. and Wewetzer, C. and Meyer, J. and Warnke, A. and Lesch, K.P. and Reinhardt, R. and Herpertz-Dahlmann, B. and Linder, M. and Hinney, A. and Remschmidt, H. and Schaefer, H. and Konrad, K. and Huebner, N. and Hebebrand, J.
Molecular Psychiatry 12 (10): 923-933. October 2007

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl, U. and Steidl, C. and Ebralidze, A. and Chapuy, B. and Han, H.J. and Will, B. and Rosenbauer, F. and Becker, A. and Wagner, K. and Koschmieder, S. and Kobayashi, S. and Costa, D.B. and Schulz, T. and OBrien, K.B. and Verhaak, R.G.W. and Delwel, R. and Haase, D. and Truemper, L. and Krauter, J. and Kohwi-Shigematsu, T. and Griesinger, F. and Tenen, D.G.
Journal of Clinical Investigation 117 (9): 2611-2620. 4 September 2007

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch, M.A. and Gong, M. and Chowdhury, D. and Senenko, L. and Engel, K. and Lee, Y.A. and de Silva, U. and Bailey, S.L. and Witte, T. and Vyse, T.J. and Kere, J. and Pfeiffer, C. and Harvey, S. and Wong, A. and Koskenmies, S. and Hummel, O. and Rohde, K. and Schmidt, R.E. and Dominiczak, A.F. and Gahr, M. and Hollis, T. and Perrino, F.W. and Lieberman, J. and Huebner, N.
Nature Genetics 39 (9): 1065-1067. September 2007

Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C. and Marenholz, I. and Kerscher, T. and Rueschendorf, F. and Esparza-Gordillo, J. and Worm, M. and Gruber, C. and Mayr, G. and Albrecht, M. and Rohde, K. and Schulz, H. and Wahn, U. and Huebner, N. and Lee, Y.A.
PLoS Biology 5 (9): e242. September 2007

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.
Borsellino, G. and Kleinewietfeld, M. and Di Mitri, D. and Sternjak, A. and Diamantini, A. and Giometto, R. and Hoepner, S. and Centonze, D. and Bernardi, G. and Dell'Acqua, M.L. and Rossini, P.M. and Battistini, L. and Roetzschke, O. and Falk, K.
Blood 110 (4): 1225-1232. 15 August 2007

Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Nocito, A. and Dahm, F. and Jochum, W. and Jang, J.H. and Georgiev, P. and Bader, M. and Renner, E.L. and Clavien, P.A.
Gastroenterology 133 (2): 608-618. August 2007

TRAIL limits excessive host immune responses in bacterial meningitis.
Hoffmann, O. and Priller, J. and Prozorovski, T. and Schulze-Topphoff, U. and Baeva, N. and Lunemann, J.D. and Aktas, O. and Mahrhofer, C. and Stricker, S. and Zipp, F. and Weber, J.R.
Journal of Clinical Investigation 117 (7): 2004-2013. 2 July 2007

Systematic discovery of in vivo phosphorylation networks.
Linding, R. and Jensen, L.J. and Ostheimer, G.J. and van Vugt, M.A. and Jorgensen, C. and Miron, I.M. and Diella, F. and Colwill, K. and Taylor, L. and Elder, K. and Metalnikov, P. and Nguyen, V. and Pasculescu, A. and Jin, J. and Park, J.G. and Samson, L.D. and Woodgett, J.R. and Russell, R.B. and Bork, P. and Yaffe, M.B. and Pawson, T.
Cell 129 (7): 1415-1426. 29 June 2007

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rust, M.B. and Alper, S.L. and Rudhard, Y. and Shmukler, B.E. and Vicente, R. and Brugnara, C. and Trudel, M. and Jentsch, T.J. and Huebner, C.A.
Journal of Clinical Investigation 117 (6): 1708-1717. 1 June 2007

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
von Vietinghoff, S. and Tuennemann, G. and Eulenberg, C. and Wellner, M. and Cardoso, M.C. and Luft, F.C. and Kettritz, R.
Blood 109 (10): 4487-4493. 15 May 2007

Regulation of the germinal center response by microRNA-155.
Thai, T.H. and Calado, D.P. and Casola, S. and Ansel, K.M. and Xiao, C. and Xue, Y. and Murphy, A. and Frendewey, D. and Valenzuela, D. and Kutok, J.L. and Schmidt-Supprian, M. and Rajewsky, N. and Yancopoulos, G. and Rao, A. and Rajewsky, K.
Science 316 (5824): 604-608. 27 April 2007

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.
Schneider, M.A. and Meingassner, J.G. and Lipp, M. and Moore, H.D. and Rot, A.
Journal of Experimental Medicine 204 (4): 735-745. 16 April 2007

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
Leach, N.T. and Sun, Y. and Michaud, S. and Zheng, Y. and Ligon, K.L. and Ligon, A.H. and Sander, T. and Korf, B.R. and Lu, W. and Harris, D.J. and Gusella, J.F. and Maas, R.L. and Quade, B.J. and Cole, A.J. and Kelz, M.B. and Morton, C.C.
American Journal of Human Genetics 80 (4): 792-799. April 2007

Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
Paul, F. and Jarius, S. and Aktas, O. and Bluthner, M. and Bauer, O. and Appelhans, H. and Franciotta, D. and Bergamaschi, R. and Littleton, E. and Palace, J. and Seelig, H.P. and Hohlfeld, R. and Vincent, A. and Zipp, F.
PLoS Medicine 4 (4): e133. April 2007

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Qi, M.L. and Tagawa, K. and Enokido, Y. and Yoshimura, N. and Wada, Y.I. and Watase, K. and Ishiura, S.I. and Kanazawa, I. and Botas, J. and Saitoe, M. and Wanker, E.E. and Okazawa, H.
Nature Cell Biology 9 (4): 402-414. April 2007

Notch signaling is essential for ventricular chamber development.
Grego-Bessa, J. and Luna-Zurita, L. and del Monte, G. and Bolos, V. and Melgar, P. and Arandilla, A. and Garratt, A.N. and Zang, H. and Mukouyama, Y.S. and Chen, H. and Shou, W. and Ballestar, E. and Esteller, M. and Rojas, A. and Perez-Pomares, J.M. and de la Pompa, J.L.
Developmental Cell 12 (3): 415-429. March 2007

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J. and Raddatz, K. and Molkentin, J.D. and Wu, Y. and Labeit, S. and Granzier, H. and Gotthardt, M.
Circulation 115 (6): 743-751. 13 February 2007

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Hoepken, U.E. and Wengner, A.M. and Loddenkemper, C. and Stein, H. and Heimesaat, M.M. and Rehm, A. and Lipp, M.
Blood 109 (3): 886-895. 1 February 2007

Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice.
Nocito, A. and Georgiev, P. and Dahm, F. and Jochum, W. and Bader, M. and Graf, R. and Clavien, P.A.
Hepatology 45 (2): 369-376. February 2007

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
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Nature Genetics 39 (2): 168-177. February 2007

Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease.
Walther, T. and Tschoepe, C. and Sterner-Kock, A. and Westermann, D. and Heringer-Walther, S. and Riad, A. and Nikolic, A. and Wang, Y. and Ebermann, L. and Siems, W.E. and Bader, M. and Shakibaei, M. and Schultheiss, H.P. and Doerner, A.
Circulation 115 (3): 333-344. 23 January 2007

Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
Oettle, H. and Post, S. and Neuhaus, P. and Gellert, K. and Langrehr, J. and Ridwelski, K. and Schramm, H. and Fahlke, J. and Zuelke, C. and Burkart, C. and Gutberlet, K. and Kettner, E. and Schmalenberg, H. and Weigang-Koehler, K. and Bechstein, W.O. and Niedergethmann, M. and Schmidt-Wolf, I. and Roll, L. and Doerken, B. and Riess, H.
JAMA: Journal of the American Medical Association 297 (3): 267-277. 17 January 2007

STAT3 and MAPK signaling maintains overexpression of the heat shock proteins 90a and b in multiple myeloma cells, which critically contribute to tumor cell survival.
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Blood 109 (2): 720-728. 15 January 2007

Active MAC-1 (CD11b/CD18) on DC is inhibitory for full T cell activation.
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Blood 109 (2): 661-669. 15 January 2007

Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.
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A stomatin-domain protein essential for touch sensation in the mouse.
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Nature 445 (7124): 206-209. 11 January 2007

Natural selection on human microRNA binding sites inferred from SNP data.
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Nature Genetics 38 (12): 1452-1456. 1 December 2006

Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia.
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American Journal of Human Genetics 79 (6): 1110-1118. December 2006

Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.
Heuser, A. and Plovie, E.R. and Ellinor, P.T. and Grossmann, K.S. and Shin, J.T. and Wichter, T. and Basson, C.T. and Lerman, B.B. and Sasse-Klaassen, S. and Thierfelder, L. and MacRae, C.A. and Gerull, B.
American Journal of Human Genetics 79 (6): 1081-1088. December 2006

Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Visekruna, A. and Joeris, T. and Seidel, D. and Kroesen, A. and Loddenkemper, C. and Zeitz, M. and Kaufmann, S.H.E. and Schmidt-Ullrich, R. and Steinhoff, U.
Journal of Clinical Investigation 116 (12): 3195-3203. December 2006

Analysis of translation initiation using a translation control reporter system.
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Nature Protocols 1 (3): 1531-1537. 9 November 2006

The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Blaydon, D.C. and Ishii, Y. and O'Toole, E.A. and Unsworth, H.C. and Teh, M.T. and Rueschendorf, F. and Sinclair, C. and Hopsu-Havu, V.K. and Tidman, N. and Moss, C. and Watson, R. and de Berker, D. and Wajid, M. and Christiano, A.M. and Kelsell, D.P.
Nature Genetics 38 (11): 1245-1247. November 2006

Targeting and tracing antigens in live cells with fluorescent nanobodies.
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Nature Methods 3 (11): 887-889. November 2006

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
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Nature Genetics 38 (11): 1269-1277. November 2006

The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
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Gastroenterology 131 (5): 1486-1500. November 2006

Control of peripheral nerve myelination by the β-secretase BACE1.
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Science 314 (5799): 664-666. 27 October 2006

Dynamic subcompartmentalization of the mitochondrial inner membrane.
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Coordination between CCR7- and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.
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Blood 108 (8): 2531-2539. 15 October 2006

Co-evolution of transcriptional and post-translational cell-cycle regulation.
Jensen, L.J. and Jensen, T.S. and de Lichtenberg, U. and Brunak, S. and Bork, P.
Nature 443 (7111): 594-597. 4 October 2006

Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.
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American Journal of Human Genetics 79 (4): 731-737. October 2006

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
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Nature Immunology 7 (10): 1037-1047. October 2006

The rototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo.
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Neuron 51 (5): 587-600. 7 September 2006

The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
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Genes & Development 20 (17): 2465-2478. 1 September 2006

Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis.
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Gastroenterology 131 (3): 765-780. September 2006

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
Gauss, R. and Jarosch, E. and Sommer, T. and Hirsch, C.
Nature Cell Biology 8 (8): 849-854. August 2006

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
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Molecular Cell 23 (1): 13-23. 7 July 2006

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
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Nature Genetics 38 (6): 668-673. June 2006

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S. and Bergmann, N. and Luo, X. and Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173 (4): 559-570. 22 May 2006

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.
Gauss, R. and Sommer, T. and Jarosch, E.
EMBO Journal 25 (9): 1827-1835. 3 May 2006

Platelet-derived serotonin mediates liver regeneration.
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Science 312 (5770): 104-107. 7 April 2006

Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lopez-Bendito, G. and Cautinat, A. and Sanchez, J.A. and Bielle, F. and Flames, N. and Garratt, A.N. and Talmage, D.A. and Role, L.W. and Charnay, P. and Marin, O. and Garel, S.
Cell 125 (1): 127-142. 7 April 2006

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich, A. and Gaumer, S. and Haacke, A. and Tzvetkov, N. and Albrecht, M. and Evert, B.O. and Mueller, E.C. and Lurz, R. and Breuer, P. and Schugardt, N. and Plassmann, S. and Xu, K. and Warrick, J.M. and Suopanki, J. and Wuellner, U. and Frank, R. and Hartl, U.F. and Bonini, N.M. and Wanker, E.E.
EMBO Journal 25 (7): 1547-1558. 5 April 2006

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I. and Koesters, C. and Unger, B. and Sekimata, M. and Hertweck, A. and Maschek, R. and Wilson, C.B. and Ellmeier, W.
Nature Immunology 7 (4): 392-400. April 2006

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells.
Janz, M. and Hummel, M. and Truss, M. and Wollert-Wulf, B. and Mathas, S. and Joehrens, K. and Hagemeier, C. and Bommert, K. and Stein, H. and Doerken, B. and Bargou, R.C.
Blood 107 (6): 2536-2539. 15 March 2006

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
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Circulation 113 (9): 1203-1212. 7 March 2006

Toward automatic reconstruction of a highly resolved tree of life.
Ciccarelli, F.D. and Doerks, T. and von Mehring, C. and Creevey, C.J. and Snel, B. and Bork, P.
Science 311 (5765): 1283-1287. 3 March 2006

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Hoshino, M. and Qi, M.L. and Yoshimura, N. and Miyashita, T. and Tagawa, K. and Wada, Y.I. and Enokido, Y. and Marubuchi, S. and Arai, P. and Arai, N. and Oyanagi, K. and Blandino, G. and Sudol, M. and Rich, T. and Kanazawa, I. and Wanker, E.E. and Saitoe, M. and Okazawa, H.
Journal of Cell Biology 172 (4): 589-604. 13 February 2006

A genome-wide scan for attention-deficit/hyperactivity disorder in 155 german sib-pairs.
Hebebrand, J. and Dempfle, A. and Saar, K. and Thiele, H. and Herpertz-Dahlmann, B. and Linder, M. and Kiefl, H. and Remschmidt, H. and Hemminger, U. and Warnke, A. and Knoelker, U. and Heiser, P. and Friedel, S. and Hinney, A. and Schaefer, H. and Nuernberg, P. and Konrad, K.
Molecular Psychiatry 11 (2): 196-205. February 2006

CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Kurobe, H. and Liu, C. and Ueno, T. and Saito, F. and Ohigashi, I. and Seach, N. and Arakaki, R. and Hayashi, Y. and Kitagawa, T. and Lipp, M. and Boyd, R.L. and Takahama, Y.
Immunity 24 (2): 165-177. February 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S. and Janz, M. and Hummel, F. and Hummel, M. and Wollert-Wulf, B. and Lusatis, S. and Anagnostopoulos, I. and Lietz, A. and Sigvardsson, M. and Jundt, F. and Joehrens, K. and Bommert, K. and Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma.
Juettner, S. and Wissmann, C. and Joens, T. and Vieth, M. and Hertel, J. and Gretschel, S. and Schlag, P.M. and Kemmner, W. and Hoecker, M.
Journal of Clinical Oncology 24 (2): 228-240. 10 January 2006

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
Eljaschewitsch, E. and Witting, A. and Mawrin, C. and Lee, T. and Schmidt, P.M. and Wolf, S. and Hoertnagl, H. and Raine, C.S. and Schneider-Stock, R. and Nitsch, R. and Ullrich, O.
Neuron 49 (1): 67-79. 5 January 2006

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F. and Owens, B.M. and Yu, L. and Tumang, J.R. and Steidl, U. and Kutok, J.L. and Clayton, L.K. and Wagner, K. and Scheller, M. and Iwasaki, H. and Liu, C. and Hackanson, B. and Akashi, K. and Leutz, A. and Rothstein, T.L. and Plass, C. and Tenen, D.G.
Nature Genetics 38 (1): 27-37. January 2006

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.
Wojnowski, L. and Kulle, B. and Schirmer, M. and Schlueter, G. and Schmidt, A. and Rosenberger, A. and Vonhof, S. and Bickeboeller, H. and Toliat, M.R. and Suk, E.K. and Tzvetkov, M. and Kruger, A. and Seifert, S. and Kloess, M. and Hahn, H. and Loeffler, M. and Nuernberg, P. and Pfreundschuh, M. and Truemper, L. and Brockmoeller, J. and Hasenfuss, G.
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The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates.
Nothnagel, M. and Rohde, K.
American Journal of Human Genetics 77 (6): 988-998. 1 December 2005

Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
Schumacher, J. and Kaneva, R. and Jamra, R.A. and Diaz, G.O. and Ohlraun, S. and Milanova, V. and Lee, Y.A. and Rivas, F. and Mayoral, F. and Fuerst, R. and Flaquer, A. and Windemuth, C. and Gay, E. and Sanz, S. and Gonzalez, M.J. and Gil, S. and Cabaleiro, F. and del Rio, F. and Perez, F. and Haro, J. and Kostov, C. and Chorbov, V. and Nikolova-Hill, A. and Stoyanova, V. and Onchev, G. and Kremensky, I. and Strauch, K. and Schulze, T.G. and Nuernberg, P. and Gaebel, W. and Klimke, A. and Auburger, G. and Wienker, T.F. and Kalaydjieva, L. and Propping, P. and Cichon, S. and Jablensky, A. and Rietschel, M. and Noethen, M.M.
American Journal of Human Genetics 77 (6): 1102-1111. 1 December 2005

Pseudo-pseudo Meigs' syndrome.
Schmitt, R. and Weichert, W. and Schneider, W. and Luft, F.C. and Kettritz, R.
Lancet 366 : 1672. 5 November 2005

Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator.
Thiel, C.T. and Horn, D. and Zabel, B. and Ekici, A.B. and Salinas, K. and Gebhart, E. and Rueschendorf, F. and Sticht, H. and Spranger, J. and Mueller, D. and Zweier, C. and Schmitt, M.E. and Reis, A. and Rauch, A.
American Journal of Human Genetics 77 (5): 795-806. 1 November 2005

Plasma exchange for primary autoimmune autonomic failure.
Schroeder, C. and Vernino, S. and Birkenfeld, A.L. and Tank, J. and Heusser, K. and Lipp, A. and Benter, T. and Lindschau, C. and Kettritz, R. and Luft, F.C. and Jordan, J.
New England Journal of Medicine 353 (15): 1585-1590. 13 October 2005

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain.
Mo, X. and Kowenz-Leutz, E. and Laumonnier, Y. and Xu, H. and Leutz, A.
Genes & Development 19 (20): 2447-2457. 29 September 2005

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U. and Worm, U. and Lalowski, M. and Haenig, C. and Brembeck, F.H. and Goehler, H. and Stroedicke, M. and Zenkner, M. and Schoenherr, A. and Koeppen, S. and Timm, J. and Mintzlaff, S. and Abraham, C. and Bock, N. and Kietzmann, S. and Goedde, A. and Toksoez, E. and Droege, A. and Krobitsch, S. and Korn, B. and Birchmeier, W. and Lehrach, H. and Wanker, E.E.
Cell 122 (6): 957-968. 23 September 2005

Ubx2 links the Cdc48 complex to ER-associated protein degradation.
Neuber, O. and Jarosch, E. and Volkwein, C. and Walter, J. and Sommer, T.
Nature Cell Biology 7 (10): 993-998. 18 September 2005

CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Vasyutina, E. and Stebler, J. and Brand-Saberi, B. and Schulz, S. and Raz, E. and Birchmeier, C.
Genes & Development 19 (18): 2187-2198. 15 September 2005

Role of endocytosis in cellular uptake of sex steroids.
Hammes, A. and Andreassen, T.K. and Spoelgen, R. and Raila, J. and Huebner, N. and Schulz, H. and Metzger, J. and Schweigert, F.J. and Luppa, P.B. and Nykjaer, A. and Willnow, T.E.
Cell 122 (5): 751-762. 9 September 2005

Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Unterstab, G. and Ludwig, S. and Anton, A. and Planz, O. and Dauber, B. and Krappmann, D. and Heins, G. and Ehrhardt, C. and Wolff, T.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13640-13645. 9 September 2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C.A.F. and Breiderhoff, T. and Jansen, P. and Wu, X. and Bales, K.R. and Cappai, R. and Masters, C.L. and Gliemann, J. and Mufson, E.J. and Hyman, B.T. and Paul, S.M. and Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. and Blankenstein, T.
Nature 437 (7055): 141-146. 1 September 2005

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S. and Joehrens, K. and Joos, S. and Lietz, A. and Hummel, F. and Janz, M. and Jundt, F. and Anagnostopoulos, I. and Bommert, K. and Lichter, P. and Stein, H. and Scheidereit, C. and Doerken, B.
Blood 106 (13): 4287-4293. 25 August 2005

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Debes, G.F. and Arnold, C.N. and Young, A.J. and Krautwald, S. and Lipp, M. and Hay, J.B. and Butcher, E.C.
Nature Immunology 6 (9): 889-894. 14 August 2005

Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment.
Vidal, V.P. and Chaboissier, M.C. and Luetzkendorf, S. and Cotsarelis, G. and Mill, P. and Hui, C.C. and Ortonne, N. and Ortonne, J.P. and Schedl, A.
Current Biology 15 (15): 1340-1351. 9 August 2005

Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M. and Lee, S. and Loddenkemper, C. and Rudolph, C. and Peters, A.H. and Schlegelberger, B. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Nature 436 (7051): 660-665. 4 August 2005

Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T. and Chatterjee, M. and Hildebrandt, M. and Herrmann, P. and Gollasch, H. and Gerecke, C. and Theurich, S. and Cigliano, L. and Manz, R.A. and Daniel, P.T. and Bommert, K. and Vassilev, L.T. and Bargou, R.C.
Blood 106 : 3609-3617. 4 August 2005

The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.
Otto, H. and Conz, C. and Maier, P. and Woelfle, T. and Suzuki, C.K. and Jenoe, P. and Ruecknagel, P. and Stahl, J. and Rospert, S.
Proceedings of the National Academy of Sciences of the United States of America 102 (29): 10064-10069. 19 July 2005

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells.
Xue, S.A. and Gao, L. and Hart, D. and Gillmore, R. and Qasim, W. and Thrasher, A. and Apperley, J. and Engels, B. and Uckert, W. and Morris, E. and Stauss, H.J.
Blood 106 : 3062-3067. 14 July 2005

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.
Sausbier, M. and Arntz, C. and Bucurenciu, I. and Zhao, H. and Zhou, X.B. and Sausbier, U. and Feil, S. and Kamm, S. and Essin, K. and Sailer, C.A. and Abdullah, U. and Krippeit-Drews, P. and Feil, R. and Hofmann, F. and Knaus, H.G. and Kenyon, C. and Shipston, M.J. and Storm, J.F. and Neuhuber, W. and Korth, M. and Schubert, R. and Gollasch, M. and Ruth, P.
Circulation 112 : 60-68. 5 July 2005

Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.
Hillmer, A.M. and Hanneken, S. and Ritzmann, S. and Becker, T. and Freudenberg, J. and Brockschmidt, F.F. and Flaquer, A. and Freudenberg-Hua, Y. and Jamra, R.A. and Metzen, C. and Heyn, U. and Schweiger, N. and Betz, R.C. and Blaumeiser, B. and Hampe, J. and Schreiber, S. and Schulze, T.G. and Hennies, H.C. and Schumacher, J. and Propping, P. and Ruzicka, T. and Cichon, S. and Wienker, T.F. and Kruse, R. and Noethen, M.M.
American Journal of Human Genetics 77 (1): 140-148. July 2005

Recruitment of DNA methyltransferase I to DNA repair sites.
Mortusewicz, O. and Schermelleh, L. and Walter, J. and Cardoso, M.C. and Leonhardt, H.
Proceedings of the National Academy of Sciences of the United States of America 102 (25): 8905-8909. 21 June 2005

Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation.
Brero, A. and Easwaran, H.P. and Nowak, D. and Grunewald, I. and Cremer, T. and Leonhardt, H. and Cardoso, M.C.
Journal of Cell Biology 169 (5): 733-743. 6 June 2005

Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Juettner, R. and More, M.I. and Das, D. and Babich, A. and Meier, J. and Henning, M. and Erdmann, B. and Mueller, E.C. and Otto, A. and Grantyn, R. and Rathjen, F.G.
Neuron 46 (2): 233-245. 21 May 2005

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
Kiyan, J. and Kiyan, R. and Haller, H. and Dumler, I.
EMBO Journal 24 (10): 1787-1797. 18 May 2005

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M. and Hoepken, U.E. and Koch, M. and Koehler, A. and Lipp, M. and Kaufmann, S.H. and Mittruecker, H.W.
Journal of Experimental Medicine 201 (9): 1447-1457. 2 May 2005

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Hill, T.P. and Spaeter, D. and Taketo, M.M. and Birchmeier, W. and Hartmann, C.
Developmental Cell 8 (5): 727-738. 1 May 2005

Systematic association of genes to phenotypes by genome and literature mining.
Korbel, J.O. and Doerks, T. and Jensen, L.J. and Perez-Iratxeta, C. and Kaczanowski, S. and Hooper, S.D. and Andrade, M.A. and Bork, P.
PLoS Biology 3 (5): e134. 5 April 2005

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
Huebner, N. and Wallace, C.A. and Zimdahl, H. and Petretto, E. and Schulz, H. and Maciver, F. and Mueller, M. and Hummel, O. and Monti, J. and Zidek, V. and Musilova, A. and Kren, V. and Causton, H. and Game, L. and Born, G. and Schmidt, S. and Mueller, A. and Cook, S.A. and Kurtz, T.W. and Whittaker, J. and Pravenec, M. and Aitman, T.J.
Nature Genetics 37 (3): 243-253. 1 March 2005

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis.
Berliocchi, L. and Fava, E. and Leist, M. and Horvat, V. and Dinsdale, D. and Read, D. and Nicotera, P.
Journal of Cell Biology 168 (4): 607-618. 14 February 2005

Dynamic complex formation during the yeast cell cycle.
de Lichtenberg, U. and Jensen, L.J. and Brunak, S. and Bork, P.
Science 307 (5710): 724-727. 4 February 2005

Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.
Christou, D.D. and Jones, P.P. and Jordan, J. and Diedrich, A. and Robertson, D. and Seals, D.R.
Circulation 111 : 494-498. 1 February 2005

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang, X. and Smith, D.L. and Meriin, A.B. and Engemann, S. and Russel, D.E. and Roark, M. and Washington, S.L. and Maxwell, M.M. and Marsh, J.L. and Thompson, L.M. and Wanker, E.E. and Young, A.B. and Housman, D.E. and Bates, G.P. and Sherman, M.Y. and Kazantsev, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102 (3): 892-897. 18 January 2005

Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.
Dimmer, K.S. and Jakobs, S. and Vogel, F. and Altmann, K. and Westermann, B.
Journal of Cell Biology 168 (1): 103-115. 3 January 2005

Complex genomic rearrangements lead to novel primate gene function.
Ciccarelli, F.D. and von Mering, C. and Suyama, M. and Harrington, E.D. and Izaurralde, E. and Bork, P.
Genome Research 15 (3): 343-351. 1 January 2005

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Ding, Q. and Xia, W. and Liu, J.C. and Yang, J.Y. and Lee, D.F. and Xia, J. and Bartholomeusz, G. and Li, Y. and Pan, Y. and Li, Z. and Bargou, R.C. and Qin, J. and Lai, C.C. and Tsai, F.J. and Tsai, C.H. and Hung, M.C.
Molecular Cell 19 : 159-170. 1 January 2005

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection (authors reply inN Engl J Med. 2005 May 12;352(19):2027-8).
Dragun, D. and Mueller, D.N. and Braesen, J.H. and Fritsche, L. and Nieminen-Kelhae, M. and Dechend, R. and Kintscher, U. and Rudolph, B. and Hoebeke, J. and Eckert, D. and Mazak, I. and Plehm, R. and Schoenemann, C. and Unger, T. and Budde, K. and Neumayer, H.H. and Luft, F.C. and Wallukat, G.
New England Journal of Medicine 352 (6): 558-569. 1 January 2005

Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Fiebeler, A. and Nussberger, J. and Shagdarsuren, E. and Rong, S. and Hilfenhaus, G. and Al-Saadi, N. and Dechend, R. and Wellner, M. and Meiners, S. and Maser-Gluth, C. and Jeng, A.Y. and Webb, R.L. and Luft, F.C. and Mueller, D.N.
Circulation 111 (23): 3087-3094. 1 January 2005

Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Freund, C. and Schmidt-Ullrich, R. and Baurand, A. and Dunger, S. and Schneider, W. and Loser, P. and El-Jamali, A. and Dietz, R. and Scheidereit, C. and Bergmann, M.W.
Circulation 111 (18): 2319-2325. 1 January 2005

A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21 (1): 8-11. 1 January 2005

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F. and Raetzel, N. and Mueller, C. and Calkhoven, C.F. and Kley, K. and Mathas, S. and Lietz, A. and Leutz, A. and Doerken, B.
Blood 106 : 1801-1807. 1 January 2005

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset.
Kleinewietfeld, M. and Puentes, F. and Borsellino, G. and Battistini, L. and Roetzschke, O. and Falk, K.
Blood 105 (7): 2877-2886. 1 January 2005

Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R. and Janz, M. and Mapara, M.Y. and Lemke, B. and Stirling, D. and Doerken, B. and Zenke, M. and Lentzsch, S.
Blood 105 (10): 3833-3840. 1 January 2005

Role of CCL21 in recruitment of T precursor cells to fetal thymus.
Liu, C. and Ueno, T. and Kuse, S. and Saito, F. and Nitta, T. and Piali, L. and Nakano, H. and Kakiuchi, T. and Lipp, M. and Hollander, G.A. and Takahama, Y.
Blood 105 (1): 31-39. 1 January 2005

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.
Metherell, L.A. and Chapple, J.P. and Cooray, S. and David, A. and Becker, C. and Rueschendorf, F. and Naville, D. and Begeot, M. and Khoo, B. and Nuernberg, P. and Huebner, A. and Cheetham, M.E. and Clark, A.J.L.
Nature Genetics 37 (2): 166-170. 1 January 2005

The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T. and Anlag, K. and Wildner, H. and Britsch, S. and Treier, M. and Birchmeier, C.
Genes & Development 19 (6): 733-743. 1 January 2005

A role for E2F6 in the restriction of male-germ-cell-specific gene expression.
Pohlers, M. and Truss, M. and Frede, U. and Scholz, A. and Strehle, M. and Kuban, R.J. and Hoffmann, B. and Morkel, M. and Birchmeier, C. and Hagemeier, C.
Current Biology 15 (11): 1051-1057. 1 January 2005

Stroma-mediated dysregulation of myelopoiesis in mice lacking IkappaBalpha.
Rupec, R.A. and Jundt, F. and Rebholz, B. and Eckelt, B. and Weindl, G.N. and Herzinger, T. and Flaig, M.J. and Moosmann, S. and Plewig, G. and Doerken, B. and Foerster, I. and Huss, R. and Pfeffer, K.
Immunity 22 : 479-491. 1 January 2005

Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study.
Thuss-Patience, P.C. and Kretzschmar, A. and Repp, M. and Kingreen, D. and Hennesser, D. and Micheel, S. and Pink, D. and Scholz, C. and Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 23 : 494-501. 1 January 2005

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P. and Kuemmel, D. and Prinz, B. and Holz, C. and Schultchen, J. and Lang, C. and Niesen, F.H. and Hofmann, K.P. and Delbrueck, H. and Behlke, J. and Mueller, E.C. and Jarosch, E. and Sommer, T. and Heinemann, U.
EMBO Journal 24 (5): 875-884. 1 January 2005

Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.
Wilkinson, C.R. and Dittmar, G.A. and Ohi, M.D. and Uetz, P. and Jones, N. and Finley, D.
Current Biology 14 : 2283-2288. 29 December 2004

Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Graveel, C. and Su, Y. and Koeman, J. and Wang, L.M. and Tessarollo, L. and Fiscella, M. and Birchmeier, C. and Swiatek, P. and Bronson, R. and Vande Woude, G.F.
Proceedings of the National Academy of Sciences of the United States of America 101 (49): 17198-17203. 7 December 2004

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz, G. and Rosario, M. and Grimm, J. and Boeckers, T.M. and Gundelfinger, E.D. and Birchmeier, W.
Journal of Cell Biology 167 (5): 945-952. 6 December 2004

The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain.
Hartmann, B. and Ahmadi, S. and Heppenstall, P.A. and Lewin, G.R. and Schott, C. and Borchardt, T. and Seeburg, P.H. and Zeilhofer, H.U. and Sprengel, R. and Kuner, R.
Neuron 44 (4): 637-650. 18 November 2004

Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B. and Heuser, A. and Wichter, T. and Paul, M. and Basson, C.T. and McDermott, D.A. and Lerman, B.B. and Markowitz, S.M. and Ellinor, P.T. and MacRae, C.A. and Peters, S. and Grossmann, K.S. and Drenckhahn, J. and Michely, B. and Sasse-Klaassen, S. and Birchmeier, W. and Dietz, R. and Breithardt, G. and Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36 (11): 1162-1164. November 2004

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Flames, N. and Long, J.E. and Garratt, A.N. and Fischer, T.M. and Gassmann, M. and Birchmeier, C. and Lai, C. and Rubenstein, J.L. and Marin, O.
Neuron 44 (2): 251-261. 14 October 2004

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S. and Grund, C. and Huelsken, J. and Behrend, M. and Erdmann, B. and Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 167 (1): 149-160. 11 October 2004

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler, H. and Lalowski, M. and Stelzl, U. and Waelter, S. and Stroedicke, M. and Worm, U. and Droege, A. and Lindenberg, K.S. and Knoblich, M. and Haenig, C. and Herbst, M. and Suopanki, J. and Scherzinger, E. and Abraham, C. and Bauer, B. and Hasenbank, R. and Fritzsche, A. and Ludewig, A.H. and Buessow, K. and Coleman, S.H. and Gutekunst, C.A. and Landwehrmeyer, B.G. and Lehrach, H. and Wanker, E.E.
Molecular Cell 15 (6): 853-865. 24 September 2004

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck, F.H. and Schwarz-Romond, T. and Bakkers, J. and Wilhelm, S. and Hammerschmidt, M. and Birchmeier, W.
Genes & Development 18 (18): 2225-2230. 15 September 2004

Dynamic targeting of the replication machinery to sites of DNA damage.
Solomon, D.A. and Cardoso, M.C. and Knudsen, E.S.
Journal of Cell Biology 166 (4): 455-463. 16 August 2004

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.
Ueno, T. and Saito, F. and Gray, D.H.D. and Kuse, S. and Hieshima, K. and Nakano, H. and Kakiuchi, T. and Lipp, M. and Boyd, R.L. and Takahama, Y.
Journal of Experimental Medicine 200 (4): 493-505. 16 August 2004

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl, L. and Mohaupt, M. and Czeloth, N. and Hintzen, G. and Kiafard, Z. and Zwirner, J. and Blankenstein, T. and Henning, G. and Foerster, R.
Immunity 21 (2): 279-288. 1 August 2004

Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.
Uhlenberg, B. and Schuelke, M. and Rueschendorf, F. and Ruf, N. and Kaindl, A.M. and Henneke, M. and Thiele, H. and Stoltenburg-Didinger, G. and Aksu, F. and Topaloglu, H. and Nuernberg, P. and Huebner, C. and Weschke, B. and Gaertner, J.
American Journal of Human Genetics 75 (2): 251-260. August 2004

Analysis of genomic context: prediction of functional associations from conserved bidirectionally transcribed gene pairs.
Korbel, J.O. and Jensen, L.J. and von Mering, C. and Bork, P.
Nature Biotechnology 22 (7): 911-917. 1 July 2004

Allelic heterogeneity in the COH1 gene explains clinical variability in Cohen syndrome.
Hennies, H.C. and Rauch, A. and Seifert, W. and Schumi, C. and Moser, E. and Al-Taji, E. and Tariverdian, G. and Chrzanowska, K.H. and Krajewska-Walasek, M. and Rajab, A. and Giugliani, R. and Neumann, T.E. and Eckl, K.M. and Karbasiyan, M. and Reis, A. and Horn, D.
American Journal of Human Genetics 75 (1): 138-145. July 2004

Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement.
Thiele, H. and Sakano, M. and Kitagawa, H. and Sugahara, K. and Rajab, A. and Hoehne, W. and Ritter, H. and Leschik, G. and Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 101 (27): 10155-10160. 23 June 2004

Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells.
Mazak, I. and Fiebeler, A. and Muller, D.N. and Park, J.K. and Shagdarsuren, E. and Lindschau, C. and Dechend, R. and Viedt, C. and Pilz, B. and Haller, H. and Luft, F.C.
Circulation 109 (22): 2792-2800. 8 June 2004

Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S. and Probst, S. and Gerull, B. and Oechslin, E. and Nuernberg, P. and Heuser, A. and Jenni, R. and Hennies, H.C. and Thierfelder, L.
Circulation 109 (22): 2720-2723. 8 June 2004

Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction.
Abdel-Aty, H. and Zagrosek, A. and Schulz-Menger, J. and Taylor, A.J. and Messroghli, D. and Kumar, A. and Gross, M. and Dietz, R. and Friedrich, M.G.
Circulation 109 (20): 2411-2416. 25 May 2004

Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V. and Sereda, M.W. and Brinkmann, B.G. and Fischer, T.M. and Haug, B. and Birchmeier, C. and Role, L. and Lai, C. and Schwab, M.H. and Nave, K.A.
Science 304 (5671): 700-703. 30 April 2004

Water potentiates the pressor effect of ephedra alkaloids.
Jordan, J. and Shannon, J.R. and Diedrich, A. and Black, B. and Robertson, D. and Biaggioni, I.
Circulation 109 (15): 1823-1825. 20 April 2004

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.
Mathas, S. and Lietz, A. and Anagnostopoulos, I. and Hummel, F. and Wiesner, B. and Janz, M. and Jundt, F. and Hirsch, B. and Joehrens-Leder, K. and Vornlocher, H.P. and Bommert, K. and Stein, H. and Doerken, B.
Journal of Experimental Medicine 199 (8): 1041-1052. 19 April 2004

Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4).
Donaudy, F. and Snoeckx, R. and Pfister, M. and Zenner, H.P. and Blin, N. and Di Stazio, M. and Ferrara, A. and Lanzara, C. and Ficarella, R. and Declau, F. and Pusch, C.M. and Nuernberg, P. and Melchionda, S. and Zelante, L. and Ballana, E. and Estivill, X. and Van Camp, G. and Gasparini, P. and Savoia, A.
American Journal of Human Genetics 74 (4): 770-776. April 2004

Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome.
Krzywinski, M. and Wallis, J. and Goesele, C. and Bosdet, I. and Chiu, R. and Graves, T. and Hummel, O. and Layman, D. and Mathewson, C. and Wye, N. and Zhu, B. and Albracht, D. and Asano, J. and Barber, S. and Brown-John, M. and Chan, S. and Chand, S. and Cloutier, A. and Davito, J. and Fjell, C. and Gaige, T. and Ganten, D. and Girn, N. and Guggenheimer, K. and Himmelbauer, H. and Kreitler, T. and Leach, S. and Lee, D. and Lehrach, H. and Mayo, M. and Mead, K. and Olson, T. and Pandoh, P. and Prabhu, A.L. and Shin, H. and Taenzer, S. and Thompson, J. and Tsai, M. and Walker, J. and Yang, G. and Sekhon, M. and Hillier, L. and Zimdahl, H. and Marziali, A. and Osoegawa, K. and Zhao, S. and Siddiqui, A. and de Jong, P.J. and Warren, W. and Mardis, E. and McPherson, J.D. and Wilson, R. and Huebner, N. and Jones, S. and Marra, M. and Schein, J.
Genome Research 14 (4): 766-779. April 2004

Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A. and Lee, R. and Teng, K.K. and Jansen, P. and Madsen, P. and Nielsen, M.S. and Jacobsen, C. and Kliemannel, M. and Schwarz, E. and Willnow, T.E. and Hempstead, B.L. and Petersen, C.M.
Nature 427 (6977): 843-848. 26 February 2004

Ras induces mediator complex exchange on C/EBPβ.
Mo, X.M. and Kowenz-Leutz, E. and Xu, H. and Leutz, A.
Molecular Cell 13 (2): 241-250. 30 January 2004

Met provides essential signals for liver regeneration.
Borowiak, M. and Garratt, A.N. and Wuestefeld, T. and Strehle, M. and Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101 (29): 10608-10613. 1 January 2004

A molecular genetic and statistical approach for the diagnosis of dual-site cancers.
Brinkmann, D. and Ryan, A. and Ayhan, A. and McCluggage, W.G. and Feakins, R. and Santibanez-Koref, M.F. and Mein, C.A. and Gayther, S.A. and Jacobs, I.J.
Journal of the National Cancer Institute 96 (19): 1441-1446. 1 January 2004

The Collaborative Cross, a community resource for the genetic analysis of complex traits.
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Nature Genetics 36 : 1133-1137. 1 January 2004

Global analysis of bacterial transcription factors to predict cellular target processes.
Doerks, T. and Andrade, M.A. and Lathe, W. and von Mering, C. and Bork, P.
Trends in Genetics 20 (3): 126-131. 1 January 2004

The HUPO PSI's Molecular Interaction format - a community standard for the representation of protein interaction data.
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Nature Biotechnology 22 (2): 177-183. 1 January 2004

Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z. and Stuewe, E.E. and Fiedler, D. and Katzer, A. and Jeggo, P.A. and Ivics, Z.
Molecular Cell 13 (2): 279-290. 1 January 2004

Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy.
Janecke, A.R. and Thompson, D.A. and Utermann, G. and Becker, C. and Huebner, C.A. and Schmid, E. and McHenry, C.L. and Nair, A.R. and Rueschendorf, F. and Heckenlively, J. and Wissinger, B. and Nuernberg, P. and Gal, A.
Nature Genetics 36 (8): 850-854. 1 January 2004

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for TH1 priming.
Martin-Fontecha, A. and Thomsen, L.L. and Brett, S. and Gerard, C. and Lipp, M. and Lanzavecchia, A. and Sallusto, F.
Nature Immunology 5 (12): 1260-1265. 1 January 2004

Serotonin regulates mammary gland development via an autocrine-paracrine loop.
Matsuda, M. and Imaoka, T. and Vomachka, A.J. and Gudelsky, G.A. and Hou, Z.Y. and Mistry, M. and Bailey, J.P. and Nieport, K.M. and Walther, D.J. and Bader, M. and Horseman, N.D.
Developmental Cell 6 (2): 193-203. 1 January 2004

Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation.
Meusser, B. and Sommer, T.
Molecular Cell 14 (2): 247-258. 1 January 2004

A dual role for lkkalpha in tooth development.
Ohazama, A. and Hu, Y.L. and Schmidt-Ullrich, R. and Cao, Y.X. and Scheidereit, C. and Karin, M. and Sharpe, P.T.
Developmental Cell 6 (2): 219-227. 1 January 2004

The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function.
Page, A.J. and Brierley, S.M. and Martin, C.M. and Martinez-Salgado, C. and Wemmie, J.A. and Brennan, T.J. and Symonds, E. and Omari, T. and Lewin, G.R. and Welsh, M.J. and Blackshaw, L.A.
Gastroenterology 127 (6): 1739-1747. 1 January 2004

Mortality and morbidity reduction with candesartan in patients with chronic heart failure and left ventricular systolic dysfunction. Results of the CHARM low-left ventricular ejection fraction trials.
Young, J.B. and Dunlap, M.E. and Pfeffer, M.A. and Probstfield, J.L. and Cohen-Solal, A. and Dietz, R. and Granger, C.B. and Hradec, J. and Kuch, J. and McKelvie, R.S. and McMurray, J.J.V. and Michelson, E.L. and Olofsson, B. and Ostergren, J. and Held, P. and Solomon, S.D. and Yusuf, S. and Swedberg, K.
Circulation 110 (17): 2618-2626. 1 January 2004

A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H. and Nyakatura, G. and Brandt, P. and Schulz, H. and Hummel, O. and Fartmann, B. and Brett, D. and Droege, M. and Monti, J. and Lee, Y.A. and Sun, Y.Y. and Zhao, S.Y. and Winter, E.E. and Ponting, C.P. and Chen, Y. and Kasprzyk, A. and Birney, E. and Ganten, D. and Huebner, N.
Science 303 (5659): 807-807. 1 January 2004

Cellular senescence in cancer treatment: friend or foe?
Kahlem, P. and Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113 (2): 169-174. January 2004

Axoplasmic importins enable retrograde injury signaling in lesioned nerve.
Hanz, S. and Perlson, E. and Willis, D. and Zheng, J.Q. and Massarwa, R. and Huerta, J.J. and Koltzenburg, M. and Koehler, M. and van Minnen, J. and Twiss, J.L. and Fainzilber, M.
Neuron 40 (6): 1095-1104. 18 December 2003

Monocyte-expressed urokinase inhibits vascular smooth muscle cell growth by activating Stat1.
Kunigal, S. and Kusch, A. and Tkachuk, N. and Tkachuk, S. and Jerke, U. and Haller, H. and Dumler, I.
Blood 102 (13): 4377-4383. 15 December 2003

Water ingestion as prophylaxis against syncope.
Lu, C.C. and Diedrich, A. and Tung, C.S. and Paranjape, S.Y. and Harris, P.A. and Byrne, D.W. and Jordan, J. and Robertson, D.
Circulation 108 (21): 2660-2665. 25 November 2003

Tumor rejection by modulation of tumor stromal fibroblasts.
Schueler, T. and Koernig, S. and Blankenstein, T.
Journal of Experimental Medicine 198 (10): 1487-1493. 17 November 2003

Role of β-catenin in synaptic vesicle localization and presynaptic assembly.
Bamji, S.X. and Shimazu, K. and Kimes, N. and Huelsken, J. and Birchmeier, W. and Lu, B. and Reichardt, L.F.
Neuron 40 (4): 719-731. November 2003

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Prinz, M. and Heikenwalder, M. and Junt, T. and Schwarz, P. and Glatzel, M. and Heppner, F.L. and Fu, Y.X. and Lipp, M. and Aguzzi, A.
Nature 425 (6961): 957-962. 30 October 2003

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
Lehmann, K. and Seemann, P. and Stricker, S. and Sammar, M. and Meyer, B. and Suering, K. and Majewski, F. and Tinschert, S. and Grzeschik, K.H. and Mueller, D. and Knaus, P. and Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12277-12282. 14 October 2003

Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M. and Rolle, S. and Wellner, M. and Cardoso, M.C. and Scheidereit, C. and Luft, F.C. and Kettritz, R.
Blood 102 (6): 2259-2267. 15 September 2003

Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B. and Sturm, I. and Lage, H. and Berger, S. and Schneider, U. and Haupfmann, S. and Wust, P. and Riess, H. and Schlag, P.M. and Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21 (18): 3391-3401. 15 September 2003

Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A. and Sebastiani, S. and Hoepken, U.E. and Uguccioni, M. and Lipp, M. and Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198 (4): 615-621. 18 August 2003

Differentiation of effector/memory V ae 2 T cells and migratory routes in lymph nodes or inflammatory sites.
Dieli, F. and Poccia, F. and Lipp, M. and Sireci, G. and Caccamo, N. and Di Sano, C. and Salerno, A.
Journal of Experimental Medicine 198 (3): 391-397. 4 August 2003

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S. and Lietz, A. and Janz, M. and Hinz, M. and Jundt, F. and Scheidereit, C. and Bommert, K. and Doerken, B.
Blood 102 (3): 1028-1034. 1 August 2003

Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation.
Dechend, R. and Gieffers, J. and Dietz, R. and Joerres, A. and Rupp, J. and Luft, F.C. and Maass, M.
Circulation 108 (3): 261-265. 22 July 2003

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B. and Essmann, F. and Graupner, V. and Staerck, L. and Radetzki, S. and Doerken, B. and Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22 (14): 3580-3590. 15 July 2003

The renal arterial resistance index and renal allograft survival.
Radermacher, J. and Mengel, M. and Ellis, S. and Stuht, S. and Hiss, M. and Schwarz, A. and Eisenberger, U. and Burg, M. and Luft, F.C. and Gwinner, W. and Haller, H.
New England Journal of Medicine 349 (2): 115-124. 10 July 2003

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Santos, R.A.S. and e Silva, A.C.S. and Maric, C. and Silva, D.M.R. and Machado, R.P. and de Buhr, I. and Heringer-Walther, S. and Pinheiro, S.V.B. and Lopes, M.T. and Bader, M. and Mendes, E.P. and Lemos, V.S. and Campagnole-Santos, M.J. and Schultheiss, H.P. and Speth, R. and Walther, T.
Proceedings of the National Academy of Sciences of the United States of America 100 (14): 8258-8263. 8 July 2003

The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold.
Ciccarelli, F.D. and Bork, P. and Kerkhoff, E.
Trends in Biochemical Sciences 28 (7): 349-352. 7 July 2003

Systematic discovery of analogous enzymes in thiamin biosynthesis.
Morett, E. and Korbel, J. and Rajan, E. and Saab-Rincon, G. and Olvera, L. and Olvera, M. and Steffen, S. and Snel, B. and Bork, P.
Nature Biotechnology 21 (7): 790-795. July 2003

A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Shin, J.B. and Martinez-Salgado, C. and Heppenstall, P.A. and Lewin, G.R.
Nature Neuroscience 6 (7): 724-730. July 2003

Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition.
Tank, J. and Schroeder, C. and Diedrich, A. and Szczech, E. and Haertter, S. and Sharma, A.M. and Luft, F.C. and Jordan, J.
Circulation 107 (23): 2949-2954. 17 June 2003

Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkins disease.
Diehl, V. and Franklin, J. and Pfreundschuh, M. and Lathan, B. and Paulus, U. and Hasenclever, D. and Tesch, H. and Herrmann, R. and Doerken, B. and Mueller-Hermelink, H.K. and Duehmke, E. and Loeffler, M.
New England Journal of Medicine 348 (24): 2386-2395. 12 June 2003

Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs.
Ohl, L. and Henning, G. and Krautwald, S. and Lipp, M. and Hardtke, S. and Bernhardt, G. and Pabst, O. and Foerster, R.
Journal of Experimental Medicine 197 (9): 1199-1204. 5 May 2003

Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S. and Gries, M. and Janz, M. and Bargou, R. and Doerken, B. and Mapara, M.Y.
Blood 101 (9): 3568-3573. 1 May 2003

Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin, Y. and Al Ghoul, L. and Kepp, O. and Meyer, T.E. and Birchmeier, W. and Naumann, M.
Journal of Cell Biology 161 (2): 249-255. 28 April 2003

Chromosomal instability and tumors promoted by DNA hypomethylation.
Eden, A. and Gaudet, F. and Waghmare, A. and Jaenisch, R.
Science 300 (5618): 455-455. 18 April 2003

Induction of tumors in mice by genomic hypomethylation.
Gaudet, F. and Hodgson, J.G. and Eden, A. and Jackson-Grusby, L. and Dausman, J. and Gray, J.W. and Leonhardt, H. and Jaenisch, R.
Science 300 (5618): 489-492. 18 April 2003

Translational control of SCL-isoform expression in hematopoietic lineage choice.
Calkhoven, C.F. and Mueller, C. and Martin, R. and Krosl, G. and Hoang, T. and Leutz, A.
Genes & Development 17 (8): 959-964. 15 April 2003

Baroreflex buffering is reduced with age in healthy men.
Jones, P.P. and Christou, D.D. and Jordan, J. and Seals, D.R.
Circulation 107 (13): 1770-1774. 8 April 2003

AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase.
Dechend, R. and Viedt, C. and Mueller, D.N. and Ugele, B. and Brandes, R.P. and Wallukat, G. and Park, J.K. and Janke, J. and Barta, P. and Theuer, J. and Fiebeler, A. and Homuth, V. and Dietz, R. and Haller, H. and Kreuzer, J. and Luft, F.C.
Circulation 107 (12): 1632-1639. 1 April 2003

Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker, C. and Kirsch, R.D. and Ju, X.S. and Hieronymus, T. and Gust, T.C. and Kuhl, C. and Jorgas, T. and Kurz, S.M. and Rose-John, S. and Yokota, Y. and Zenke, M.
Nature Immunology 4 (4): 380-386. April 2003

Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
Geier, C. and Perrot, A. and Ozcelik, C. and Binner, P. and Counsell, D. and Hoffmann, K. and Pilz, B. and Martiniak, Y. and Gehmlich, K.A. and van der Ven, P.F.M. and Furst, D.O. and Vornwald, A. and von Hodenberg, E. and Nuernberg, P. and Scheffold, T. and Dietz, R. and Osterziel, K.J.
Circulation 107 (10): 1390-1395. 18 March 2003

Neuronal or glial progeny: Regional differences in radial glia fate.
Malatesta, P. and Hack, M.A. and Hartfuss, E. and Kettenmann, H. and Klinkert, W. and Kirchhoff, F. and Goetz, M.
Neuron 37 (5): 751-764. 6 March 2003

Increase of functional diversity by alternative splicing.
Kriventseva, E.V. and Koch, I. and Apweiler, R. and Vingron, M. and Bork, P. and Gelfand, M.S. and Sunyaev, S.
Trends in Genetics 19 (3): 124-128. March 2003

The inner membrane protein Mdm33 controls mitochondrial morphology in yeast.
Messerschmitt, M. and Jakobs, S. and Vogel, F. and Fritz, S. and Dimmer, K.S. and Neupert, W. and Westermann, B.
Journal of Cell Biology 160 (4): 553-564. 18 February 2003

Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions.
Aicher, A. and Heeschen, C. and Mohaupt, M. and Cooke, J.P. and Zeiher, A.M. and Dimmeler, S.
Circulation 107 (4): 604-611. 4 February 2003

Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial.
Kerr, D.J. and McArdle, C.S. and Ledermann, J. and Taylor, I. and Sherlock, D.J. and Schlag, P.M. and Buckels, J. and Mayer, D. and Cain, D. and Stephens, R.J.
Lancet 361 (1): 368-373. 1 February 2003

Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma.
Smith, J.R. and Braziel, R.M. and Paoletti, S. and Lipp, M. and Uguccioni, M. and Rosenbaum, J.T.
Blood 101 (3): 815-821. 1 February 2003

Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Walther, D.J. and Peter, J.U. and Bashammakh, S. and Hoertnagl, H. and Voits, M. and Fink, H. and Bader, M.
Science 299 (5603): 76-76. 3 January 2003

Blood oxygen level-dependent magnetic resonance imaging in patients with stress-induced angina.
Friedrich, M.G. and Niendorf, T. and Schulz-Menger, J. and Gross, C.M. and Dietz, R.
Circulation 108 (18): 2219-2223. 1 January 2003

Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release.
Lisi, S. and Pinchera, A. and McCluskey, R.T. and Willnow, T.E. and Refetoff, S. and Marcocci, C. and Vitti, P. and Menconi, F. and Grasso, L. and Luchetti, F. and Collins, A.B. and Marino, M.
Proceedings of the National Academy of Sciences of the United States of America 100 (25): 14858-14863. 1 January 2003

Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.
Rutsch, F. and Ruf, N. and Vaingankar, S. and Toliat, M.R. and Suk, A. and Hoehne, W. and Schauer, G. and Lehmann, M. and Roscioli, T. and Schnabel, D. and Epplen, J.T. and Knisely, A. and Superti-Furga, A. and McGill, J. and Filippone, M. and Sinaiko, A.R. and Vallance, H. and Hinrichs, B. and Smith, W. and Ferre, M. and Terkeltaub, R. and Nuernberg, P.
Nature Genetics 34 (4): 379-381. 1 January 2003

Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Soshnikova, N. and Zechner, D. and Huelsken, J. and Mishina, Y. and Behringer, R.R. and Taketo, M.M. and Crenshaw, E.B. and Birchmeier, W.
Genes & Development 17 (16): 1963-1968. 1 January 2003

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release.
Walther, D.J. and Peter, J.U. and Winter, S. and Hoeltje, M. and Paulmann, N. and Grohmann, M. and Vowinckel, J. and Alamo-Bethencourt, V. and Wilhelm, C.S. and Ahnert-Hilger, G. and Bader, M.
Cell 115 (7): 851-862. 1 January 2003

Deletion of beta-catenin impairs T cell development.
Xu, Y. and Banerjee, D. and Huelsken, J. and Birchmeier, W. and Sen, J.M.
Nature Immunology 4 (12): 1177-1182. 1 January 2003

Genome evolution reveals biochemical networks and functional modules.
von Mering, C. and Zdobnov, E.M. and Tsoka, S. and Ciccarelli, F.D. and Pereira-Leal, J.B. and Ouzounis, C.A. and Bork, P.
Proceedings of the National Academy of Sciences of the United States of America 100 (26): 15428-15433. 1 January 2003

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Roetzschke, O. and Lau, J.M. and Hofstaetter, M. and Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16946-16950. 24 December 2002

A role for Neuregulin1 signaling in muscle spindle differentiation.
Hippenmeyer, S. and Shneider, N.A. and Birchmeier, C. and Burden, S.J. and Jessell, T.M. and Arber, S.
Neuron 36 (6): 1035-1049. 19 December 2002

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser, V. and Engemann, S. and Broecker, W. and Dunkel, I. and Boeddrich, A. and Waelter, S. and Nordhoff, E. and Lurz, R. and Schugardt, N. and Rautenberg, S. and Herhaus, C. and Barnickel, G. and Boettcher, H. and Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 99 (Suppl 4): 16400-16406. 10 December 2002

DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.
Sporbert, A. and Gahl, A. and Ankerhold, R. and Leonhardt, H. and Cardoso, M.C.
Molecular Cell 10 (6): 1355-1365. December 2002

Water drinking acutely improves orthostatic tolerance in healthy subjects.
Schroeder, C. and Bush, V.E. and Norcliffe, L.J. and Luft, F.C. and Tank, J. and Jordan, J. and Hainsworth, R.
Circulation 106 (22): 2806-2811. 26 November 2002

Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey.
Cleland, J.G.F. and Cohen-Solal, A. and Aguilar, J.C. and Dietz, R. and Eastaugh, J. and Follath, F. and Freemantle, N. and Gavazzi, A. and van Gilst, W.H. and Hobbs, F.D.R. and Korewicki, J. and Madeira, H.C. and Preda, I. and Swedberg, K. and Widimsky, J.
Lancet 360 (9346): 1631-1639. 23 November 2002

Hemodynamic and neurohumoral effects of selective endothelin A (ET(A))receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade trial (HEAT).
Luescher, T.F. and Enseleit, F. and Pacher, R. and Mitrovic, V. and Schulze, M.R. and Willenbrock, R. and Dietz, R. and Rousson, V. and Huerlimann, D. and Philipp, S. and Notter, T. and Noll, G. and Ruschitzka, F.
Circulation 106 (21): 2666-2672. 19 November 2002

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
Calado, A. and Treichel, N. and Mueller, E.C. and Otto, A. and Kutay, U.
EMBO Journal 21 (22): 6216-6224. 15 November 2002

Metabolic network structure determines key aspects of functionality and regulation.
Stelling, J. and Klamt, S. and Bettenbrock, K. and Schuster, S. and Gilles, E.D.
Nature 420 (6912): 190-193. 14 November 2002

cGMP-mediated signaling via cGKIαs required for the guidance and connectivity of sensory axons.
Schmidt, H. and Werner, M. and Heppenstall, P.A. and Henning, M. and More, M.I. and Kuehbandner, S. and Lewin, G.R. and Hofmann, F. and Feil, R. and Rathjen, F.G.
Journal of Cell Biology 159 (3): 489-498. 11 November 2002

Paradoxical effect of sibutramine on autonomic cardiovascular regulation.
Birkenfeld, A.L. and Schroeder, C. and Boschmann, M. and Tank, J. and Franke, G. and Luft, F.C. and Biaggioni, I. and Sharma, A.M. and Jordan, J.
Circulation 106 (19): 2459-2465. 5 November 2002

Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients with dilated cardiomyopathy.
Staudt, A. and Boehm, M. and Knebel, F. and Grosse, Y. and Bischoff, C. and Hummel, A. and Dahm, J.B. and Borges, A. and Jochmann, N. and Wernecke, K.D. and Wallukat, G. and Baumann, G. and Felix, S.B.
Circulation 106 (19): 2448-2453. 5 November 2002

A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution.
Otto, E. and Hoefele, J. and Ruf, R. and Mueller, A.M. and Hiller, K.S. and Wolf, M.T.F. and Schuermann, M.J. and Becker, A. and Birkenhaeger, R. and Sudbrak, R. and Hennies, H.C. and Nuernberg, P. and Hildebrandt, F.
American Journal of Human Genetics 71 (5): 1161-1167. November 2002

Modulation of QT interval during autonomic nervous system blockade in humans.
Diedrich, A. and Jordan, J. and Shannon, J.R. and Robertson, D. and Biaggioni, I.
Circulation 106 (17): 2238-2243. 22 October 2002

Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer.
Grinstein, E. and Wernet, P. and Snijders, P.J.F. and Rosl, F. and Weinert, I. and Jia, W.T. and Kraft, R. and Schewe, C. and Schwabe, M. and Hauptmann, S. and Dietel, M. and Meijer, C.J.L.M. and Royer, H.D.
Journal of Experimental Medicine 196 (8): 1067-1078. 21 October 2002

EcoRII: a restriction enzyme evolving recombination functions.
Muecke, M. and Grelle, G. and Behlke, J. and Kraft, R. and Krueger, D.H. and Reuter, M.
EMBO Journal 21 (19): 5262-5268. 1 October 2002

Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M. and Lemke, P. and Anagnostopoulos, I. and Hacker, C. and Krappmann, D. and Mathas, S. and Doerken, B. and Zenke, M. and Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196 (5): 605-617. 2 September 2002

CD4+CD3- cells induce Peyer's patch development: role of α4 β1 integrin activation by CXCR5.
Finke, D. and Acha-Orbea, H. and Mattis, A. and Lipp, M. and Kraehenbuhl, J.P.
Immunity 17 (3): 363-373. September 2002

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond, T. and Asbrand, C. and Bakkers, J. and Kuehl, M. and Schaeffer, H.J. and Huelsken, J. and Behrens, J. and Hammerschmidt, M. and Birchmeier, W.
Genes & Development 16 (16): 2073-2084. 15 August 2002

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S. and Hinz, M. and Anagnostopoulos, L. and Krappmann, D. and Lietz, A. and Jundt, F. and Bommert, K. and Mechta-Grigoriou, F. and Stein, H. and Doerken, B. and Scheidereit, C.
EMBO Journal 21 (15): 4104-4113. 1 August 2002

In vivo bradykinin B2 receptor activation reduces renal fibrosis.
Schanstra, J.P. and Neau, E. and Drogoz, P. and Gomez, M.A.A. and Novoa, J.M.L. and Calise, D. and Pecher, C. and Bader, M. and Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 110 (3): 371-379. 1 August 2002

Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly).
Hoffmann, K. and Dreger, C.K. and Olins, A.L. and Olins, D.E. and Shultz, L.D. and Lucke, B. and Karl, H. and Kaps, R. and Mueller, D. and Vaya, A. and Aznar, J. and Ware, R.E. and Cruz, N.S. and Lindner, T.H. and Herrmann, H. and Reis, A. and Sperling, K.
Nature Genetics 31 (4): 410-414. August 2002

Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC.
Li, P.F. and Li, J.C. and Mueller, E.C. and Otto, A. and Dietz, R. and von Harsdorf, R.
Molecular Cell 10 (2): 247-258. August 2002

Catechol-O-methyltransferase and blood pressure in humans.
Jordan, J. and Lipp, A. and Tank, J. and Schroeder, C. and Stoffels, M. and Franke, G. and Diedrich, A. and Arnold, G. and Goldstein, D.S. and Sharma, A.M. and Luft, F.C.
Circulation 106 (4): 460-465. 23 July 2002

Chemokine requirements for B cell entry to lymph nodes and Peyers patches.
Okada, T. and Ngo, V.N. and Ekland, E.H. and Foerster, R. and Lipp, M. and Littman, D.R. and Cyster, J.G.
Journal of Experimental Medicine 196 (1): 65-75. 1 July 2002

Association of genes to genetically inherited diseases using data mining.
Perez-Iratxeta, C. and Bork, P. and Andrade, M.A.
Nature Genetics 31 (3): 316-319. July 2002

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Oezcelik, C. and Erdmann, B. and Pilz, B. and Wettschureck, N. and Britsch, S. and Huebner, N. and Chien, K.R. and Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99 (13): 8880-8885. 25 June 2002

Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
Mukouyama, Y. and Shin, D. and Britsch, S. and Taniguchi, M. and Anderson, D.J.
Cell 109 (6): 693-705. 14 June 2002

Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure - Results from 2 placebo-controlled studies.
Doehner, W. and Schoene, N. and Rauchhaus, M. and Leyva-Leon, F. and Pavitt, D.V. and Reaveley, D.A. and Schuler, G. and Coats, A.J.S. and Anker, S.D. and Hambrecht, R.
Circulation 105 (22): 2619-2624. 4 June 2002

Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction.
Qin, Z. and Kim, H.J. and Hemme, J. and Blankenstein, T.
Journal of Experimental Medicine 195 (11): 1479-1490. 3 June 2002

The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Mueller, T. and Brohmann, H. and Pierani, A. and Heppenstall, P.A. and Lewin, G.R. and Jessell, T.M. and Birchmeier, C.
Neuron 34 (4): 551-562. 16 May 2002

Calcineurin in human heart hypertrophy.
Ritter, O. and Hack, S. and Schuh, K. and Roethlein, N. and Perrot, A. and Osterziel, K.J. and Schulte, H.D. and Neyses, L.
Circulation 105 (19): 2265-2269. 14 May 2002

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt, C.A. and Fridman, J.S. and Yang, M. and Lee, S. and Baranov, E. and Hoffman, R.M. and Lowe, S.W.
Cell 109 (3): 335-346. 3 May 2002

Mapping of gene loci for nephronophthisis type 4 and Senior-Loken syndrome, to chromosome 1p36.
Schuermann, M.J. and Otto, E. and Becker, A. and Saar, K. and Rueschendorf, F. and Polak, B.C. and Ala-Mello, S. and Hoefele, J. and Wiedensohler, A. and Haller, M. and Omran, H. and Nuernberg, P. and Hildebrandt, F.
American Journal of Human Genetics 70 (5): 1240-1246. May 2002

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques.
Perutz, M.F. and Pope, B.J. and Owen, D. and Wanker, E.E. and Scherzinger, E.
Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5596-5600. 16 April 2002

VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways.
Mueller, A. and Rassow, J. and Grimm, J. and Machuy, N. and Meyer, T.F. and Rudel, T.
EMBO Journal 21 (8): 1916-1929. 15 April 2002

BSD: a novel domain in transcription factors and synapse-associated proteins.
Doerks, T. and Huber, S. and Buchner, E. and Bork, P.
Trends in Biochemical Sciences 27 (4): 168-170. 1 April 2002

Baroreflex buffering and susceptibility to vasoactive drugs.
Jordan, J. and Tank, J. and Shannon, J.R. and Diedrich, A. and Lipp, A. and Schroeder, C. and Arnold, G. and Sharma, A.M. and Biaggioni, I. and Robertson, D. and Luft, F.C.
Circulation 105 (12): 1459-1464. 26 March 2002

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y. and Krause, G. and Scheffner, M. and Zechner, D. and Leddy, H.E.M. and Behrens, J. and Sommer, T. and Birchmeier, W.
Nature Cell Biology 4 (3): 222-231. 1 March 2002

Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms (Reprinted from Current Opinion in Structural Biology, vol 11, pg 125-130, 2001).
Sunyaev, S.R. and Lathe, W. and Bork, P.
Trends in Genetics (Suppl. March): S19-S24. March 2002

Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning.
Faendrich, F. and Lin, X. and Chai, G.X. and Schulze, M. and Ganten, D. and Bader, M. and Holle, J. and Huang, D.S. and Parwaresch, R. and Zavazava, N. and Binas, B.
Nature Medicine 8 : 171-178. 1 February 2002

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
Jarosch, E. and Taxis, C. and Volkwein, C. and Bordallo, J. and Finley, D. and Wolf, D.H. and Sommer, T.
Nature Cell Biology 4 (2): 134-139. 1 February 2002

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Gerull, B. and Gramlich, M. and Atherton, J. and McNabb, M. and Trombitas, K. and Sasse-Klaassen, S. and Seidman, J.G. and Seidman, C. and Granzier, H. and Labeit, S. and Frenneaux, M. and Thierfelder, L.
Nature Genetics 30 (2): 201-204. February 2002

Targeting kinin B1 receptor for therapeutic neovascularization.
Emanueli, C. and Salis, M.B. and Stacca, T. and Pintus, G. and Kirchmair, R. and Isner, J.M. and Pinna, A. and Gaspa, L. and Regoli, D. and Cayla, C. and Pesquero, J.B. and Bader, M. and Madeddu, P.
Circulation 105 : 360-366. 22 January 2002

Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance.
Schroeder, C. and Tank, J. and Boschmann, M. and Diedrich, A. and Sharma, A.M. and Biaggioni, I. and Luft, F.C. and Jordan, J.
Circulation 105 (3): 347-353. 22 January 2002

Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
Hampe, J. and Frenzel, H. and Mirza, M.M. and Croucher, P.J. and Cuthbert, A. and Mascheretti, S. and Huse, K. and Platzer, M. and Bridger, S. and Meyer, B. and Nuernberg, P. and Stokkers, P. and Krawczak, M. and Mathew, C.G. and Curran, M. and Schreiber, S.
Proceedings of the National Academy of Sciences of the United States of America 99 (1): 321-326. 8 January 2002

Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease.
Bolger, A.P. and Sharma, R. and Li, W. and Leenarts, M. and Kalra, P.R. and Kemp, M. and Coats, A.J.S. and Anker, S.D. and Gatzoulis, M.A.
Circulation 106 : 92-99. 1 January 2002

Alternative splicing and genome complexity.
Brett, D. and Pospisil, H. and Valcarel, J. and Reich, J. and Bork, P.
Nature Genetics 30 (1): 29-30. 1 January 2002

A comprehensive linkage analysis for myocardial infarction and its related risk factors.
Broeckel, U. and Hengstenberg, C. and Mayer, B. and Holmer, S. and Martin, L.J. and Comuzzie, A.G. and Blangero, J. and Nuernberg, P. and Reis, A. and Riegger, G.A.J. and Jacob, H.J. and Schunkert, H.
Nature Genetics 30 : 210-214. 1 January 2002

CASH - a beta-helix domain widespread among carbohydrate-binding proteins.
Ciccarelli, F.D. and Copley, R.R. and Doerks, T. and Russell, R.B. and Bork, P.
Trends in Biochemical Sciences 27 (2): 59-62. 1 January 2002

AMOP, a protein module aternativelly spliced in cancer cells.
Ciccarelli, F.D. and Doerks, T. and Bork, P.
Trends in Biochemical Sciences 27 : 113-115. 1 January 2002

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.
Postigo, A. and Calella, A.M. and Fritzsch, B. and Knipper, M. and Katz, D. and Eilers, A. and Schimmang, T. and Lewin, G.R. and Klein, R. and Minichiello, L.
Genes & Development 16 (5): 633-645. 1 January 2002

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Reif, K. and Ekland, E.H. and Ohl, L. and Nakano, H. and Lipp, M. and Foerster, R. and Cyster, J.G.
Nature 416 : 94-99. 1 January 2002

Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T. and Hara, K. and Willis, M.S. and Malin, M.A. and Hoepken, U.E. and Gray, D.H.D. and Matsushima, K. and Lipp, M. and Springer, T.A. and Boyd, R.L. and Yoshie, O. and Takahama, Y.
Immunity 16 (2): 205-218. 1 January 2002

The Wilms' tumor gene Wt1 is required for normal development of the retina.
Wagner, K.D. and Wagner, N. and Vidal, V.P.I. and Schley, G. and Wilhelm, D. and Schedl, A. and Englert, C. and Scholz, H.
EMBO Journal 21 : 1398-1405. 1 January 2002

Assessment of survival in patients with primary pulmonary hypertension importance of cardiopulmonary exercise testing.
Wensel, R. and Opitz, C.F. and Anker, S.D. and Winkler, J. and Hoffken, G. and Kleber, F.X. and Sharma, R. and Hummel, M. and Hetzer, R. and Ewert, R.
Circulation 106 (3): 319-324. 1 January 2002

The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice.
Price, M.P. and McIlwrath, S.L. and Xie, J.H. and Cheng, C. and Qiao, J. and Tarr, D.E. and Sluka, K.A. and Brennan, T.J. and Lewin, G.R. and Welsh, M.J.
Neuron 32 (6): 1071-1083. 20 December 2001

CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: Modulation by FTY720.
Henning, G. and Ohl, H. and Junt, T. and Reiterer, P. and Brinkmann, V. and Nakano, H. and Hohenberger, W. and Lipp, M. and Foerster, R.
Journal of Experimental Medicine 194 (12): 1875-1881. 17 December 2001

Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T. and Kammertoens, T. and Preiss, S. and Debs, P. and Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194 (12): 1767-1775. 17 December 2001

Tumor rejection by disturbing tumor stroma cell interactions.
Ibe, S. and Qin, Z.H. and Schueler, T. and Preiss, S. and Blankenstein, T.
Journal of Experimental Medicine 194 (11): 1549-1559. 3 December 2001

Genomics boosts mouse molecular genetics.
Birchmeier, C. and Treier, M.
Trends in Genetics 17 (12): 691-692. 1 December 2001

Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment.
Priller, J. and Fluegel, A. and Wehner, T. and Boentert, M. and Haas, C.A. and Prinz, M. and Fernandez-Klett, F. and Prass, K. and Bechmann, I. and de Boer, B.A. and Frotscher, M. and Kreutzberg, G.W. and Persons, D.A. and Dirnagl, U.
Nature Medicine 7 (12): 1356-1361. 1 December 2001

Exciting you: signals from another kingdom.
Schipke, C.G. and Spier, A.D.
Trends in Neurosciences 24 (12): 692. 1 December 2001

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
Holst, P.J. and Rosenkilde, M.M. and Manfra, D. and Chen, S.C. and Wiekowski, M.T. and Holst, B. and Cifire, F. and Lipp, M. and Schwartz, T.W. and Lira, S.A.
Journal of Clinical Investigation 108 (12): 1789-1796. December 2001

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.
Priller, J. and Persons, D.A. and Klett, F.F. and Kempermann, G. and Kreutzberg, G.W. and Dirnagl, U.
Journal of Cell Biology 155 (5): 733-738. 26 November 2001

CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H. and Naegler, K. and Schumacher, S. and Goeritz, C. and Mueller, E.C. and Otto, A. and Pfrieger, F.W.
Science 294 (5545): 1354-1357. 9 November 2001

Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope.
Stienekemeier, M. and Falk, K. and Roetzschke, O. and Weishaupt, A. and Schneider, C. and Toyka, K.V. and Gold, R. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13872-13877. 1 November 2001

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice.
Drab, M. and Verkade, P. and Elger, M. and Kasper, M. and Lohn, M. and Lauterbach, B. and Menne, J. and Lindschau, C. and Mende, F. and Luft, F.C. and Schedl, A. and Haller, H. and Kurzchalia, T.V.
Science 293 (5539): 2449-2452. 28 September 2001

Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.
Hammes, A. and Guo, J.K. and Lutsch, G. and Leheste, J.R. and Landrock, D. and Ziegler, U. and Gubler, M.C. and Schedl, A.
Cell 106 (3): 319-329. 10 August 2001

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm, J. and Sachs, M. and Britsch, S. and Di Cesare, S. and Schwarz-Romond, T. and Birchmeier, W.
Journal of Cell Biology 154 (2): 345-354. 23 July 2001

Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation.
More, M.I. and Kirsch, F.P. and Rathjen, F.G.
Journal of Cell Biology 154 (1): 187-196. 9 July 2001

BDNF but not NT-4 is required for normal flexion reflex plasticity and function.
Heppenstall, P.A. and Lewin, G.R.
Proceedings of the National Academy of Sciences of the United States of America 98 (14): 8107-8112. 3 July 2001

Sox9 induces testis development in XX transgenic mice.
Vidal, V.P.I. and Chaboissier, M.C. and de Rooij, D.G. and Schedl, A.
Nature Genetics 28 (3): 216-217. 1 July 2001

Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C. and Schoser, B.G.H. and Kasper, D. and Ricker, K. and Ramirez, A. and Stein, V. and Torbergsen, T. and Lee, Y.A. and Nothen, M.M. and Wienker, T.F. and Malin, J.P. and Propping, P. and Reis, A. and Mortier, W. and Jentsch, T.J. and Vorgerd, M. and Kubisch, C.
Nature Genetics 28 (3): 218-219. July 2001

Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC.
Ishikawa, S. and Sato, T. and Abe, M. and Nagai, S. and Onai, N. and Yoneyama, H. and Zhang, Y.Y. and Suzuki, T. and Hashimoto, S. and Shirai, T. and Lipp, M. and Matsushima, K.
Journal of Experimental Medicine 193 (12): 1393-1402. 18 June 2001

Inversions and the dynamics of eukaryotic gene order.
Huynen, M.A. and Snel, B. and Bork, P.
Trends in Genetics 17 (6): 304-306. 1 June 2001

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Huelsken, J. and Vogel, R. and Erdmann, B. and Cotsarelis, G. and Birchmeier, W.
Cell 105 (4): 533-545. 18 May 2001

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
Rehm, A. and Stern, P. and Ploegh, H.L. and Tortorella, D.
EMBO Journal 20 (7): 1573-1582. 2 April 2001

Skewed maturation of memory HIV-specific CD8 T lymphocytes.
Champagne, P. and Ogg, G.S. and King, A.S. and Knabenhans, C. and Ellefsen, K. and Nobile, M. and Appay, V. and Rizzardi, G.P. and Fleury, S. and Lipp, M. and Foerster, R. and Rowland-Jones, S. and Sekaly, R.P. and McMichael, A.J. and Pantaleo, G.
Nature 410 (6824): 106-111. 1 March 2001

A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22.
Vanita, A. and Singh, J.R. and Sarhadi, V.K. and Singh, D. and Reis, A. and Rueschendorf, F. and Becker-Follmann, J. and Jung, M. and Sperling, K.
American Journal of Human Genetics 68 (2): 509-514. February 2001

Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H. and Mueller, M. and Boehmer, S.A. and Frank, C. and Weidner, K.M. and Birchmeier, W. and Ligensa, T. and Berndt, A. and Kosmehl, H. and Gunther, B. and Mueller, T. and Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152 (2): 325-334. 22 January 2001

Activation of the Notch-regulated transcription factor CBF1/RBP-J kappa through the 13SE1A oncoprotein.
Ansieau, S. and Strobl, L.J. and Leutz, A.
Genes & Development 15 (4): 380-385. 1 January 2001

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Bech-Otschir, D. and Kraft, R. and Huang, X.H. and Henklein, P. and Kapelari, B. and Pollmann, C. and Dubiel, W.
EMBO Journal 20 (7): 1630-1639. 1 January 2001

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.
Becker, C. and Pohla, H. and Frankenberger, B. and Schueler, T. and Assenmacher, M. and Schendel, D.J. and Blankenstein, T.
Nature Medicine 7 (10): 1159-1162. 1 January 2001

The transcription factor Sox10 is a key regulator of peripheral glial development.
Britsch, S. and Goerich, D.E. and Riethmacher, D. and Peirano, R.I. and Rossner, M. and Nave, K.A. and Birchmeier, C. and Wegner, M.
Genes & Development 15 (1): 66-78. 1 January 2001

Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Dechend, R. and Fiebeler, A. and Park, J.K. and Muller, D.N. and Theuer, J. and Mervaala, E. and Bieringer, M. and Gulba, D. and Dietz, R. and Luft, F.C. and Haller, H.
Circulation 104 : 576-581. 1 January 2001

DDT - a novel domain in different transcription and chromosome remodeling factors.
Doerks, T. and Copley, R. and Bork, P.
Trends in Biochemical Sciences 26 : 145-146. 1 January 2001

Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1.
Grohmann, K. and Schuelke, M. and Diers, A. and Hoffmann, K. and Lucke, B. and Adams, C. and Bertini, E. and Leonhardt-Horti, H. and Muntoni, F. and Ouvrier, R. and Pfeufer, A. and Rossi, R. and Van Maldergem, L. and Wilmshurst, J.M. and Wienker, T.R. and Sendtner, M. and Rudnik-Schoeneborn, S. and Zerres, K. and Huebner, C.
Nature Genetics 29 (1): 75-77. 1 January 2001

Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Jacobs, A. and Voges, J. and Reszka, R. and Lercher, M. and Gossmann, A. and Kracht, L. and Kaestle, C. and Wagner, R. and Wienhard, K. and Heiss, W.D.
Lancet 358 (9283): 727-729. 1 January 2001

Altered autonomic support of arterial blood pressure with age in healthy men.
Jones, P.P. and Shapiro, L.F. and Keisling, G.A. and Jordan, J. and Shannon, J.R. and Quaife, R.A. and Seals, D.R.
Circulation 104 : 2424-2429. 1 January 2001

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki, R. and Fyfe, J. and Verroust, P.J. and Jacobsen, C. and Dautry-Varsat, A. and Gburek, J. and Willnow, T.E. and Christensen, E.I. and Moestrup, S.K.
Proceedings of the National Academy of Sciences of the United States of America 98 (22): 12491-12496. 1 January 2001

Identification, by homozygosity mapping, of a novel locus for autosomal recessive congenital ichthyosis on chromosome 17p, and evidence for further genetic heterogeneity.
Krebsova, A. and Kuester, W. and Lestringant, G.G. and Schulze, B. and Hinz, B. and Frossard, P.M. and Reis, A. and Hennies, H.C.
American Journal of Human Genetics 69 (1): 216-222. 1 January 2001

A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3.
Leal, A. and Morera, B. and del Valle, G. and Heuss, D. and Kayser, C. and Berghoff, M. and Villegas, R. and Hernandez, E. and Mendez, M. and Hennies, H.C. and Neundoerfer, B. and Barrantes, R. and Reis, A. and Rautenstrauss, B.
American Journal of Human Genetics 68 : 269-274. 1 January 2001

In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Mehrhof, F.B. and Mueller, F.U. and Bergmann, M.W. and Li, P.F. and Wang, Y.B. and Schmitz, W. and Dietz, R. and von Harsdorf, R.
Circulation 104 : 2088-2094. 1 January 2001

Importin 13: a novel mediator of nuclear import and export.
Mingot, J.M. and Kostka, S. and Kraft, R. and Hartmann, E. and Goerlich, D.
EMBO Journal 20 : 3685-3694. 1 January 2001

S100A1: A regulator of myocardial contractility.
Most, P. and Bernotat, J. and Ehlermann, P. and Pleger, S.T. and Reppel, M. and Boerries, M. and Niroomand, F. and Pieske, B. and Janssen, P.M.L. and Eschenhagen, T. and Karczewski, P. and Smith, G.L. and Koch, W.J.K. and Katus, H.A. and Remppis, A.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13889-13894. 1 January 2001

Sequence interpretation - Functional annotation of mouse genome sequences.
Nadeau, J.H. and Balling, R. and Barsh, G. and Beier, D. and Brown, S.D.M. and Bucan, M. and Camper, S. and Carlson, G. and Copeland, N. and Eppig, J. and Fletcher, C. and Frankel, W.N. and Ganten, D. and Goldowitz, D. and Goodnow, C. and Guenet, J.L. and Hicks, G. and de Angelis, M.H. and Jackson, I. and Jacob, H.J. and Jenkins, N. and Johnson, D. and Justice, M. and Kay, S. and Kingsley, D. and Lehrach, H. and Magnuson, T. and Meisler, M. and Poustka, A.M. and Rinchik, E.M. and Rossant, J. and Russell, L.B. and Schimenti, J. and Shiroishi, T. and Skarnes, W.C. and Soriano, P. and Stanford, W. and Takahashi, J.S. and Wurst, W. and Zimmer, A.
Science 291 : 1251-1255. 1 January 2001

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.
Nuernberg, P. and Thiele, H. and Chandler, D. and Hoehne, W. and Cunningham, M.L. and Ritter, H. and Leschik, G. and Uhlmann, K. and Mischung, C. and Harrop, K. and Goldblatt, J. and Borochowitz, Z.U. and Kotzot, D. and Westermann, F. and Mundlos, S. and Braun, H.S. and Laing, N. and Tinschert, S.
Nature Genetics 28 (1): 37-41. 1 January 2001

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3.
Nykjaer, A. and Fyfe, J.C. and Kozyraki, R. and Leheste, J.R. and Jacobsen, C. and Nielsen, M.S. and Verroust, P.J. and Aminoff, M. and de la Chapelle, A. and Moestrup, S.K. and Ray, R. and Gliemann, J. and Willnow, T.E. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13895-13900. 1 January 2001

Cooperation between C/EBP alphaTBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Pedersen, T.A. and Kowenz-Leutz, E. and Leutz, A. and Nerlov, C.
Genes & Development 15 (21): 3208-3216. 1 January 2001

Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick.
Perrin, F.E. and Rathjen, F.G. and Stoeckli, E.T.
Neuron 30 (3): 707-723. 1 January 2001

Cooperation and competition in the evolution of ATP-producing pathways.
Pfeiffer, T. and Schuster, S. and Bonhoeffer, S.
Science 292 : 504-507. 1 January 2001

Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance - Marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis.
Ponikowski, P. and Francis, D.P. and Piepoli, M.F. and Davies, L.C. and Chua, T.P. and Davos, C.H. and Florea, V. and Banasiak, W. and Poole-Wilson, P.A. and Coats, A.J.S. and Anker, S.D.
Circulation 103 : 967-972. 1 January 2001

Peripheral chemoreceptor hypersensitivity - An ominous sign in patients with chronic heart failure.
Ponikowski, P. and Chua, T.P. and Anker, S.D. and Francis, D.P. and Doehner, W. and Banasiak, W. and Poole-Wilson, P.A. and Piepoli, M.F. and Coats, A.J.S.
Circulation 104 (5): 544-549. 1 January 2001

LG/LNS domains: multiple functions - one business end?
Rudenko, G. and Hohenester, E. and Muller, Y.A.
Trends in Biochemical Sciences 26 (6): 363-368. 1 January 2001

Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Schwartz, T. and Behlke, J. and Lowenhaupt, K. and Heineman, U. and Rich, A.
Nature Structural Biology 8 (9): 761-765. 1 January 2001

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
Slaugenhaupt, S.A. and Blumenfeld, A. and Gill, S.P. and Leyne, M. and Mull, J. and Cuajungco, M.P. and Liebert, C.B. and Chadwick, B. and Idelson, M. and Reznik, L. and Robbins, C.M. and Makalowska, I. and Brownstein, M.J. and Krappmann, D. and Scheidereit, C. and Maayan, C. and Axelrod, F.B. and Gusella, J.F.
American Journal of Human Genetics 68 : 598-605. 1 January 2001

Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution.
Staudt, A. and Schaeper, F. and Stangl, V. and Plagemann, A. and Bohm, M. and Merkel, K. and Wallukat, G. and Wernecke, K.D. and Stangl, K. and Baumann, G. and Felix, S.B.
Circulation 103 (22): 2681-2686. 1 January 2001

Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms.
Sunyaev, S.R. and Lathe, W. and Bork, P.
Current Opinion in Structural Biology 11 (1): 125-130. 1 January 2001

Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.
Ugolini, S. and Arpin, C. and Anfossi, N. and Walzer, T. and Cambiaggi, A. and Foerster, R. and Lipp, M. and Toes, R.E.M. and Melief, C.J. and Marvel, J. and Vivier, E.
Nature Immunology 2 (5): 430-435. 1 January 2001

Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
Urlaub, H. and Raker, V.A. and Kostka, S. and Luehrmann, R.
EMBO Journal 20 (1-2): 187-196. 1 January 2001

Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.
Walter, J. and Urban, J. and Volkwein, C. and Sommer, T.
EMBO Journal 20 (12): 3124-3131. 1 January 2001

Paternal relatedness and age proximity regulate social relationships among adult female rhesus macaques.
Widdig, A. and Nuernberg, P. and Krawczak, M. and Streich, W.J. and Bercovitch, F.B.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13769-13773. 1 January 2001

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.
Yang, X. and Arber, S. and William, C. and Li, L. and Tanabe, Y. and Jessell, T.M. and Birchmeier, C. and Burden, S.J.
Neuron 30 (2): 399-410. 1 January 2001

Plasma Cytokine Parameters and Mortality in Patients with Chronic Heart Failure.
Rauchhaus, M. and Doehner, W. and Francis, D.P. and Davos, C. and Kemp, M. and Liebenthal, C. and Niebauer, J. and Hooper, J. and Volk, H.D. and Coats, A.J.S. and Anker, S.D.
Circulation 102 (25): 3060-3067. 19 December 2000

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production.
Breitfeld, D. and Ohl, L. and Kremmer, E. and Ellwart, J. and Sallusto, F. and Lipp, M. and Foerster, R.
Journal of Experimental Medicine 192 (11): 1545-1551. 4 December 2000

CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.
Schaerli, P. and Willimann, K. and Lang, A.B. and Lipp, M. and Loetscher, P. and Moser, B.
Journal of Experimental Medicine 192 (11): 1553-1562. 4 December 2000

Genes that control the development of migrating muscle precursor cells.
Birchmeier, C. and Brohmann, H.
Current Opinion in Cell Biology 12 (6): 725-730. 1 December 2000

A region on chromosome 3 is linked to dizygotic twinning.
Busjahn, A. and Knoblauch, H. and Faulhaber, H.D. and Aydin, A. and Uhlmann, R. and Tuomilehto, J. and Kaprio, J. and Jedrusik, P. and Januszewicz, A. and Strelau, J. and Schuster, H. and Luft, F.C. and Mueller-Myhsok, B.
Nature Genetics 26 (4): 398-399. 1 December 2000

A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee, Y.A. and Wahn, U. and Kehrt, R. and Tarani, L. and Businco, L. and Gustafsson, D. and Andersson, F. and Oranje, A.P. and Wolkertstorfer, A. and von Berg, A. and Hoffmann, U. and Kuester, W. and Wienker, T.F. and Rueschendorf, F. and Reis, A.
Nature Genetics 26 : 470-473. 1 December 2000

Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact.
Jordan, J. and Toka, H.R. and Heusser, K. and Toka, O. and Shannon, J.R. and Tank, J. and Diedrich, A. and Stabroth, C. and Stoffels, M. and Naraghi, R. and Oelkers, W. and Schuster, H. and Schobel, H.P. and Haller, H. and Luft, F.C.
Circulation 102 : 2611-2618. 21 November 2000

Structural genomics in Europe: slow start, strong finish?
Heinemann, U.
Nature Structural Biology 7 (Suppl): 940-942. 1 November 2000

Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15.
Stoeber, G. and Saar, K. and Rueschendorf, F. and Meyer, J. and Nuernberg, G. and Jatzke, S. and Franzek, E. and Reis, A. and Lesch, K.P. and Wienker, T.F. and Beckmann, H.
American Journal of Human Genetics 67 : 1201-1207. 1 November 2000

The mammalian sodium channel BNC1 is required for normal touch sensation.
Price, M.P. and Lewin, G.R. and McIlwrath, S.L. and Cheng, C. and Xie, J.H. and Heppenstall, P.A. and Stucky, C.L. and Mannsfeldt, A.G. and Brennan, T.J. and Drummond, H.A. and Qiao, J. and Benson, C.J. and Tarr, D.E. and Hrstka, R.F. and Yang, B.L. and Williamson, R.A. and Welsh, M.J.
Nature 407 (6807): 1007-1011. 26 October 2000

Severe mitral regurgitation after valve replacement as cause of pulmonary venous aneurysm.
Christow, S.P. and Dietz, R.
Circulation 102 (17): 2159-2160. 24 October 2000

Both beta2- and beta1-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling ofbeta2-adrenergic receptors to G(s)-protein.
Molenaar, P. and Bartel, S. and Cochrane, A. and Vetter, D. and Jalali, H. and Pohlner, P. and Burrell, K. and Karczewski, P. and Krause, E.G. and Kaumann, A.
Circulation 102 (15): 1814-1821. 10 October 2000

Gene context conservation of a higher order than operons.
Lathe, W.C. and Snel, B. and Bork, P.
Trends in Biochemical Sciences 25 (10): 474-479. 1 October 2000

Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Lee, Y.A. and Rueschendorf, F. and Windemuth, C. and Schmitt-Egenolf, M. and Stadelmann, A. and Nuernberg, G. and Staender, M. and Wienker, T.F. and Reis, A. and Traupe, H.
American Journal of Human Genetics 67 (4): 1020-1024. 1 October 2000

Cross-talk in kidney development.
Schedl, A. and Hastie, N.D.
Current Opinion in Genetics & Development 10 (5): 543-549. 1 October 2000

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R. and Ruiz, P. and Diaz-Cano, S. and Luz, A. and Jagmohan-Changur, S. and Breukel, C. and Birchmeier, C. and Birchmeier, W. and Fodde, R.
Gastroenterology 119 (4): 1045-1053. 1 October 2000

Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M. and Brohmann, H. and Zechner, D. and Mueller, T. and Huelsken, J. and Walther, I. and Schaeper, U. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150 (6): 1375-1384. 18 September 2000

The endotoxin-lipoprotein hypothesis.
Rauchhaus, M. and Coats, A.J.S. and Anker, S.D.
Lancet 356 (9233): 930-933. 9 September 2000

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Lipowsky, G. and Bischoff, F.R. and Schwarzmaier, P. and Kraft, R. and Kostka, S. and Hartmann, E. and Kutay, U. and Goerlich, D.
EMBO Journal 19 : 4362-4371. 15 August 2000

Localization of a gene for syndactyly type 1 to chromosome 2q34-q36.
Bosse, K. and Betz, R.C. and Lee, Y.A. and Wienker, T.F. and Reis, A. and Kleen, H. and Propping, P. and Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 67 : 492-497. 1 August 2000

SNP frequencies in human genes - an excess of rare alleles and differing modes of selection.
Sunyaev, S.R. and Lathe, W.C. and Ramensky, V.E. and Bork, P.
Trends in Genetics 16 (8): 335-337. 1 August 2000

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
de Angelis, M.H. and Flaswinkel, H. and Fuchs, H. and Rathkolb, B. and Soewarto, D. and Marschall, S. and Heffner, S. and Pargent, W. and Wuensch, K. and Jung, M. and Reis, A. and Richter, T. and Alessandrini, F. and Jakob, T. and Fuchs, E. and Kolb, H. and Kremmer, E. and Schaeble, K. and Rollinski, B. and Roscher, A. and Peters, C. and Meitinger, T. and Strom, T. and Steckler, T. and Holsboer, F. and Klopstock, T. and Gekeler, F. and Schindewolf, C. and Jung, T. and Avraham, K. and Behrendt, H. and Ring, J. and Zimmer, A. and Schughart, K. and Pfeffer, K. and Wolf, E. and Balling, R.
Nature Genetics 25 : 444-447. 1 August 2000

A chemokine-driven positive feedback loop organizes lymphoid follicles.
Ansel, K.M. and Ngo, V.N. and Hyman, P.L. and Luther, S.A. and Foerster, R. and Sedgwick, J.D. and Browning, J.L. and Lipp, M. and Cyster, J.G.
Nature 406 (6793): 309-314. 20 July 2000

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Nylandsted, J. and Rohde, M. and Brand, K. and Bastholm, L. and Elling, F. and Jaattela, M.
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 7871-7876. 5 July 2000

Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.
Pesquero, J.B. and Araujo, R.C. and Heppenstall, P.A. and Stucky, C.L. and Silva, J.A. and Walther, T. and Oliveira, S.M. and Pesquero, J.L. and Paiva, A.C.M. and Calixto, J.B. and Lewin, G.R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 8140-8145. 5 July 2000

L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7.
Doerks, T. and Bork, P. and Kamberov, E. and Makarova, O. and Muecke, S. and Margolis, B.
Trends in Biochemical Sciences 25 : 317-318. 1 July 2000

Automated annotation of GPI anchor sites: case study C-elegans.
Eisenhaber, B. and Bork, P. and Yuan, Y.P. and Loeffler, G. and Eisenhaber, F.
Trends in Biochemical Sciences 25 (7): 340-341. 1 July 2000

A regulatory link between ER-associated protein degradation and the unfolded-protein response.
Friedlander, R. and Jarosch, E. and Urban, J. and Volkwein, C. and Sommer, T.
Nature Cell Biology 2 (7): 379-384. 1 July 2000

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper, U. and Gehring, N.H. and Fuchs, K.P. and Sachs, M. and Kempkes, B. and Birchmeier, W.
Journal of Cell Biology 149 (7): 1419-1432. 26 June 2000

A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
Betz, R.C. and Lee, Y.A. and Bygum, A. and Brandrup, F. and Bernal, A.I. and Toribio, J. and Alvarez, J.I. and Kukuk, G.M. and Ibsen, H.H.W. and Rasmussen, H.B. and Wienker, T.F. and Reis, A. and Propping, P. and Kruse, R. and Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 66 : 1979-1983. 1 June 2000

Exploitation of gene context.
Huynen, M.A. and Snel, B. and Lathe, W. and Bork, P.
Current Opinion in Structural Biology 10 (3): 366-370. 1 June 2000

Smooth-muscle contraction without smooth-muscle myosin.
Morano, I. and Chai, G.X. and Baltas, L.G. and Lamounier-Zepter, V. and Lutsch, G. and Kott, M. and Haase, H. and Bader, M.
Nature Cell Biology 2 (6): 371-375. 1 June 2000

CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNgamma receptor expression by nonhematopoietic cells.
Qin, Z.H. and Blankenstein, T.
Immunity 12 (6): 677-686. 1 June 2000

More than 1,000 putative new human signalling proteins revealed by EST data mining.
Schultz, J. and Doerks, T. and Ponting, C.P. and Copley, R.R. and Bork, P.
Nature Genetics 25 (2): 201-204. 1 June 2000

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis.<