Helmholtz Gemeinschaft


High Impact Publications (Impact Factor > 10)

Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Date | Item Type | Divisions


Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens.
Numberger, D. and Zoccarato, L. and Woodhouse, J. and Ganzert, L. and Sauer, S. and García Márquez, J.R. and Domisch, S. and Grossart, H.P. and Greenwood, A.D.
Science of the Total Environment 845 : 157321. 1 November 2022

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I. and Seeger, T. and Bruyneel, A.A.N. and Termglinchan, V. and Monte, E. and Lim, E.W. and Vadgama, N. and Furihata, T. and Gavidia, A.A. and Arthur Ataam, J. and Bharucha, N. and Martinez-Amador, N. and Ameen, M. and Nair, P. and Serrano, R. and Kaur, B. and Feyen, D.A.M. and Diecke, S. and Snyder, M.P. and Metallo, C.M. and Mercola, M. and Karakikes, I.
European Heart Journal 43 (36): 3477-3489. 21 September 2022

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 15 September 2022 (In Press)

Drivers and determinants of strain dynamics following fecal microbiota transplantation.
Schmidt, T.S.B. and Li, S.S. and Maistrenko, O.M. and Akanni, W. and Coelho, L.P. and Dolai, S. and Fullam, A. and Glazek, A.M. and Hercog, R. and Herrema, H. and Jung, F. and Kandels, S. and Orakov, A. and Thielemann, R. and von Stetten, M. and Van Rossum, T. and Benes, V. and Borody, T.J. and de Vos, W.M. and Ponsioen, C.Y. and Nieuwdorp, M. and Bork, P.
Nature Medicine 15 September 2022 (In Press)

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G. and Vanzo, R. and Amitash, S. and Martín-Doncel, E. and Coscia, F. and Mund, A. and Lerdrup, M. and Benada, J. and Boos, D. and Toledo, L.
Molecular Cell 82 (18): 3350-3365.e7. 15 September 2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S. and Müllerke, S. and Arnold, A. and Heuberger, J. and Berger, H. and Lin, M. and Mollenkopf, H.J. and Wizenty, J. and Horst, D. and Tacke, F. and Sigal, M.
Journal of Clinical Investigation : e151363. 13 September 2022 (In Press)

The role of optical coherence tomography criteria and machine learning in multiple sclerosis and optic neuritis diagnosis.
Kenney, R.C. and Liu, M. and Hasanaj, L. and Joseph, B. and Al-Hassan, A.A. and Balk, L.J. and Behbehani, R. and Brandt, A. and Calabresi, P.A. and Frohman, E. and Frohman, T.C. and Havla, J. and Hemmer, B. and Jiang, H. and Knier, B. and Korn, T. and Leocani, L. and Martinez-Lapiscina, E.H. and Papadopoulou, A. and Paul, F. and Petzold, A. and Pisa, M. and Villoslada, P. and Zimmermann, H. and Thorpe, L.E. and Ishikawa, H. and Schuman, J.S. and Wollstein, G. and Chen, Y. and Saidha, S. and Galetta, S. and Balcer, L.J.
Neurology 99 (11): e1100-e1112. 13 September 2022

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.
Eichinger, A. and Poetschger, U. and Glogova, E. and Bader, P. and Basu, O. and Beier, R. and Burkhardt, B. and Classen, C.F. and Claviez, A. and Corbacioglu, S. and Deubzer, H.E. and Greil, J. and Gruhn, B. and Güngör, T. and Kafa, K. and Kühl, J.S. and Lang, P. and Lange, B.S. and Meisel, R. and Müller, I. and Sauer, M.G. and Schlegel, P.G. and Schulz, A. and Stachel, D. and Strahm, B. and Wawer, A. and Peters, C. and Albert, M.H.
Leukemia 12 September 2022 (In Press)

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
Poetz, F. and Lebedeva, S. and Schott, J. and Lindner, D. and Ohler, U. and Stoecklin, G.
Genome Biology 23 (1): 193. 12 September 2022

Cellular hierarchies predict drug response in acute myeloid leukemia.
Raffel, S. and Velten, L. and Haas, S.
Cancer Cell 40 (9): 917-919. 12 September 2022

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R. and Rautenstrauch, P. and Ghanbari, M. and James, A.R. and Kirchler, M. and Ohler, U. and Konigorski, S. and Lippert, C.
Nature Communications 13 (1): 5332. 10 September 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. and Kocks, C. and Leiz, J. and Karaiskos, N. and Boltengagen, A. and Cao, S. and Skopnik, C.M. and Klocke, J. and Hardenberg, J.H. and Stockmann, H. and Gotthardt, I. and Obermayer, B. and Haghverdi, L. and Wyler, E. and Landthaler, M. and Bachmann, S. and Hocke, A.C. and Corman, V. and Busch, J. and Schneider, W. and Himmerkus, N. and Bleich, M. and Eckardt, K.U. and Enghard, P. and Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M. and Foglierini, M. and Khorkova, S. and Vázquez García, C. and Ratswohl, C. and Davydov, A.N. and Turchaninova, M.A. and Daubenberger, C. and Chudakov, D.M. and Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations.
Malin-Mayor, C. and Hirsch, P. and Guignard, L. and McDole, K. and Wan, Y. and Lemon, W.C. and Kainmueller, D. and Keller, P.J. and Preibisch, S. and Funke, J.
Nature Biotechnology 5 September 2022 (In Press)

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann, C. and Spallek, R. and Karpiuk, O. and Heider, M. and Schäffer, I. and Zecha, J. and Klaeger, S. and Walzik, M. and Öllinger, R. and Engleitner, T. and Wirth, M. and Keller, U. and Krönke, J. and Rudelius, M. and Kossatz, S. and Rad, R. and Kuster, B. and Bassermann, F.
EMBO Journal : e110871. 5 September 2022 (In Press)

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T. and Funck, K. and Wollweber, F. and Lisicki, E. and von der Malsburg, K. and von der Malsburg, A. and Laborenz, J. and Noel, J.K. and Hessenberger, M. and Jungbluth, S. and Bernert, C. and Kunz, S. and Riedel, D. and Lilie, H. and Jakobs, S. and van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D. and Borsa, M. and Puleston, D.J. and Zellner, S. and Capera, J. and Sanderson, S. and Schifferer, M. and Hester, S.S. and Ge, X. and Fischer, R. and Jostins, L. and Behrends, C. and Alsaleh, G. and Simon, A.K.
Nature Communications 13 (1): 5174. 2 September 2022

Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J. and Berangi, M. and Yiannakou, C. and Silva, E. and Francischello, R. and Kuehne, A. and Niendorf, T. and Könneker, S. and Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15 : 382-391. September 2022

Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N. and Jahn, E. and Saadati, M. and Bullinger, L. and Larson, R.A. and Ottone, T. and Amadori, S. and Prior, T.W. and Brandwein, J.M. and Appelbaum, F.R. and Medeiros, B.C. and Tallman, M.S. and Ehninger, G. and Heuser, M. and Ganser, A. and Pallaud, C. and Gathmann, I. and Krzykalla, J. and Benner, A. and Bloomfield, C.D. and Thiede, C. and Stone, R.M. and Döhner, H. and Döhner, K.
Leukemia 36 (9): 2218-2227. September 2022

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L. and Braun, J. and Fauchere, F. and Vanshylla, K. and Loyal, L. and Henze, L. and Kruse, B. and Dingeldey, M. and Jürchott, K. and Mangold, M. and Maraj, A. and Braginets, A. and Böttcher, C. and Nitsche, A. and de la Rosa, K. and Ratswohl, C. and Sawitzki, B. and Holenya, P. and Reimer, U. and Sander, L.E. and Klein, F. and Paul, F. and Bellmann-Strobl, J. and Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Longitudinal retinal changes in MOGAD.
Oertel, F.C. and Sotirchos, E.S. and Zimmermann, H.G. and Motamedi, S. and Specovius, S. and Asseyer, E.S. and Chien, C. and Cook, L. and Vasileiou, E. and Filippatou, A. and Calabresi, P.A. and Saidha, S. and Pandit, L. and D'Cunha, A. and Outteryck, O. and Zéphir, H. and Pittock, S. and Flanagan, E.P. and Bhatti, M.T. and Rommer, P.S. and Bsteh, G. and Zrzavy, T. and Kuempfel, T. and Aktas, O. and Ringelstein, M. and Albrecht, P. and Ayzenberg, I. and Pakeerathan, T. and Knier, B. and Aly, L. and Asgari, N. and Soelberg, K. and Marignier, R. and Tilikete, C.F. and Calvo, A.C. and Villoslada, P. and Sanchez-Dalmau, B. and Martinez-Lapiscina, E.H. and Llufriu, S. and Green, A.J. and Yeaman, M.R. and Smith, T.J. and Brandt, A.U. and Chen, J. and Paul, F. and Havla, J.
Annals of Neurology 92 (3): 476-485. September 2022

Mutations in TAF8 cause a neurodegenerative disorder.
Wong, K.M. and Jepsen, W.M. and Efthymiou, S. and Salpietro, V. and Sanchez-Castillo, M. and Yip, J. and Kriouile, Y. and Diegmann, S. and Dreha-Kulaczewski, S. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Toosi, M.B. and Akhondian, J. and Ghayoor Karimiani, E. and Hummel-Abmeier, H. and Huppke, B. and Houlden, H. and Gärtner, J. and Maroofian, R. and Huppke, P.
Brain 145 (9): 3022-3034. September 2022

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso, I. and Zujo, L. and Wiest, I. and Kodajova, P. and Timelthaler, G. and Edtmayer, S. and Zrimšek, M. and Kollmann, S. and Giordano, C. and Kothmayer, M. and Neubauer, H.A. and Dey, S. and Schlederer, M. and Schmalzbauer, B.S. and Limberger, T. and Probst, C. and Pusch, O. and Högler, S. and Tangermann, S. and Merkel, O. and Schiefer, A.I. and Kornauth, C. and Prutsch, N. and Zimmerman, M. and Abraham, B. and Anagnostopoulos, J. and Quintanilla-Martinez, L. and Mathas, S. and Wolf, P. and Stoiber, D. and Staber, P.B. and Egger, G. and Klapper, W. and Woessmann, W. and Look, T.A. and Gunning, P. and Turner, S.D. and Moriggl, R. and Lagger, S. and Kenner, L.
Molecular Cancer 21 (1): 172. 31 August 2022

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity.
Kedor, C. and Freitag, H. and Meyer-Arndt, L. and Wittke, K. and Hanitsch, L.G. and Zoller, T. and Steinbeis, F. and Haffke, M. and Rudolf, G. and Heidecker, B. and Bobbert, T. and Spranger, J. and Volk, H.D. and Skurk, C. and Konietschke, F. and Paul, F. and Behrends, U. and Bellmann-Strobl, J. and Scheibenbogen, C.
Nature Communications 13 (1): 5104. 30 August 2022

Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J. and Kim, S.J. and Skopnik, C.M. and Hinze, C. and Boltengagen, A. and Metzke, D. and Grothgar, E. and Prskalo, L. and Wagner, L. and Freund, P. and Görlich, N. and Muench, F. and Schmidt-Ott, K.M. and Mashreghi, M.F. and Kocks, C. and Eckardt, K.U. and Rajewsky, N. and Enghard, P.
Kidney International 29 August 2022 (In Press)

ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.
Tsybulskyi, V. and Meyer, I.M.
Nucleic Acids Research 50 (15): e85. 26 August 2022

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Zeppenfeld, K. and Tfelt-Hansen, J. and de Riva, M. and Winkel, B.G. and Behr, E.R. and Blom, N.A. and Charron, P. and Corrado, D. and Dagres, N. and de Chillou, C. and Eckardt, L. and Friede, T. and Haugaa, K.H. and Hocini, M. and Lambiase, P.D. and Marijon, E. and Merino, J.L. and Peichl, P. and Priori, S.G. and Reichlin, T. and Schulz-Menger, J. and Sticherling, C. and Tzeis, S. and Verstrael, A. and Volterrani, M.
European Heart Journal : ehac262. 26 August 2022 (In Press)

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019.
Tran, K.B. and Lang, J.J. and Compton, K. and Xu, R. and Acheson, A.R. and Henrikson, H.J. and Kocarnik, J.M. and Penberthy, L. and Aali, A. and Abbas, Q. and Abbasi, B. and Abbasi-Kangevari, M. and Abbasi-Kangevari, Z. and Abbastabar, H. and Abdelmasseh, M. and Abd-Elsalam, S. and Abdelwahab, A.A. and Abdoli, G. and Abdulkadir, H.A. and Abedi, A. and Abegaz, K.H. and Abidi, H. and Aboagye, R.G. and Abolhassani, H. and Absalan, A. and Abtew, Yo.D. and Abubaker Ali, H. and Abu-Gharbieh, E. and Achappa, B. and Acuna, J.M. and Addison, D. and Addo, I.Y. and Adegboye, O.A. and Adesina, M.A. and Adnan, M. and Adnani, Q.E.S. and Advani, S.M. and Afrin, S. and Afzal, M.S. and Aggarwal, M. and Ahinkorah, B.O. and Ahmad, A.R. and Ahmad, R. and Ahmad, S. and Ahmad, S. and Ahmadi, S. and Ahmed, H. and Ahmed, L.A. and Ahmed, M.B. and Ahmed Rashid, T. and Aiman, W. and Ajami, M. and Akalu, G.T. and Akbarzadeh-Khiavi, M. and Aklilu, A. and Akonde, M. and Akunna, C.J. and Al Hamad, H. and Alahdab, F. and Alanezi, F.M. and Alanzi, T.M. and Alessy, S.A. and Algammal, A.M. and Al-Hanawi, M.K. and Alhassan, R.K. and Ali, B.A. and Ali, L. and Ali, S.S. and Alimohamadi, Y. and Alipour, V. and Aljunid, S.M. and Alkhayyat, M. and Al-Maweri, S.A.A. and Almustanyir, S. and Alonso, N. and Alqalyoobi, S. and Al-Raddadi, R.M. and Al-Rifai, R.H.H. and Al-Sabah, S.K. and Al-Tammemi, A.B. and Altawalah, H. and Alvis-Guzman, N. and Amare, F. and Ameyaw, E.K. and Aminian Dehkordi, J.J. and Amirzade-Iranaq, M.H. and Amu, H. and Amusa, G.A. and Ancuceanu, R. and Anderson, J.A. and Animut, Y.A. and Anoushiravani, A. and Anoushirvani, A.A. and Ansari-Moghaddam, A. and Ansha, M.G. and Antony, B. and Antwi, M.H. and Anwar, S.L. and Anwer, R. and Anyasodor, A.E. and Arabloo, J. and Arab-Zozani, M. and Aremu, O. and Argaw, A.M. and Ariffin, H. and Aripov, T. and Arshad, M. and Artaman, A. and Arulappan, J. and Aruleba, R.T. and Aryannejad, A. and Asaad, M. and Asemahagn, M.A. and Asemi, Z. and Asghari-Jafarabadi, M. and Ashraf, T. and Assadi, R. and Athar, M. and Athari, S.S. and Atout, M.M.W. and Attia, S. and Aujayeb, A. and Ausloos, M. and Avila-Burgos, L. and Awedew, A.F. and Awoke, M.A. and Awoke, T. and Ayala Quintanilla, B.P. and Ayana, T.M. and Ayen, S.S. and Azadi, D. and Azadnajafabad, S. and Azami-Aghdash, S. and Azanaw, M.M. and Azangou-Khyavy, M. and Azari Jafari, A. and Azizi, H. and Azzam, A.Y.Y. and Babajani, A. and Badar, M. and Badiye, A.D. and Baghcheghi, N. and Bagheri, N. and Bagherieh, S. and Bahadory, S. and Baig, A.A. and Baker, J.L. and Bakhtiari, A. and Bakshi, R.K. and Banach, M. and Banerjee, I. and Bardhan, M. and Barone-Adesi, F. and Barra, F. and Barrow, A. and Bashir, N.Z. and Bashiri, A. and Basu, S. and Batiha, A.M.M. and Begum, A. and Bekele, A.B. and Belay, A.S. and Belete, M.A. and Belgaumi, U.I. and Bell, A.W. and Belo, L. and Benzian, H. and Berhie, A.Y. and Bermudez, A.N.C. and Bernabe, E. and Bhagavathula, A.S. and Bhala, N. and Bhandari, B.B. and Bhardwaj, N. and Bhardwaj, P. and Bhattacharyya, K. and Bhojaraja, V.S. and Bhuyan, S.S. and Bibi, S. and Bilchut, A.H. and Bintoro, B.S. and Biondi, A. and Birega, M.G.B. and Birhan, H.E. and Bjørge, T. and Blyuss, O. and Bodicha, B.B.A. and Bolla, S.R. and Boloor, A. and Bosetti, C. and Braithwaite, D. and Brauer, M. and Brenner, H. and Briko, A.N. and Briko, N.I. and Buchanan, C.M. and Bulamu, N.B. and Bustamante-Teixeira, M.T. and Butt, M.H. and Butt, N.S. and Butt, Z.A. and Caetano dos Santos, F.L. and Cámera, L.A. and Cao, C. and Cao, Y. and Carreras, G. and Carvalho, M. and Cembranel, F. and Cerin, E. and Chakraborty, P.A. and Charalampous, P. and Chattu, V.K. and Chimed-Ochir, O. and Chirinos-Caceres, J.L. and Cho, D.Y. and Cho, W.C.S. and Christopher, D.J. and Chu, D.T. and Chukwu, I.S. and Cohen, A.J. and Conde, J. and Cortés, S. and Costa, V.M. and Cruz-Martins, N. and Culbreth, G.T. and Dadras, O. and Dagnaw, F.T. and Dahlawi, S.M.A and Dai, X. and Dandona, L. and Dandona, R. and Daneshpajouhnejad, P. and Danielewicz, A. and Dao, A.T.M. and Darvishi Cheshmeh Soltani, R. and Darwesh, A.M. and Das, S. and Davitoiu, D.V. and Davtalab Esmaeili, E. and De la Hoz, F.P. and Debela, S.A. and Dehghan, A. and Demisse, B. and Demisse, F.W. and Denova-Gutiérrez, E. and Derakhshani, A. and Derbew Molla, M. and Dereje, D. and Deribe, K.S. and Desai, R. and Desalegn, M.D. and Dessalegn, F.N. and Dessalegni, S.A.A. and Dessie, G. and Desta, A.A. and Dewan, S.M.R. and Dharmaratne, S.D. and Dhimal, M. and Dianatinasab, M. and Diao, N. and Diaz, D. and Digesa, L.E. and Dixit, S.G. and Doaei, S. and Doan, L.P. and Doku, P.N. and Dongarwar, D. and dos Santos, W.M. and Driscoll, T.R. and Dsouza, H.L. and Durojaiye, O.C. and Edalati, S. and Eghbalian, F. and Ehsani-Chimeh, E. and Eini, E. and Ekholuenetale, M. and Ekundayo, T.C. and Ekwueme, D.U. and El Tantawi, M. and Elbahnasawy, M.A. and Elbarazi, I. and Elghazaly, H. and Elhadi, M. and El-Huneidi, W. and Emamian, M.H. and Engelbert Bain, L. and Enyew, D.B. and Erkhembayar, R. and Eshetu, T. and Eshrati, B. and Eskandarieh, S. and Espinosa-Montero, J. and Etaee, F. and Etemadimanesh, A. and Eyayu, T. and Ezeonwumelu, I.J. and Ezzikouri, S. and Fagbamigbe, A.F. and Fahimi, S. and Fakhradiyev, I.R. and Faraon, E.J.A. and Fares, J. and Farmany, A. and Farooque, U. and Farrokhpour, H. and Fasanmi, A.O. and Fatehizadeh, A. and Fatima, W. and Fattahi, H. and Fekadu, G. and Feleke, B.E. and Ferrari, A.A. and Ferrero, S. and Ferro Desideri, L. and Filip, I. and Fischer, F. and Foroumadi, R. and Foroutan, M. and Fukumoto, T. and Gaal, P.A. and Gad, M.M. and Gadanya, M.A. and Gaipov, A. and Galehdar, N. and Gallus, S. and Garg, T. and Gaspar Fonseca, M. and Gebremariam, Y.H. and Gebremeskel, T.G. and Gebremichael, M.A. and Geda, Y.F. and Gela, Y.Y. and Gemeda, B.N.B. and Getachew, M. and Getachew, M.E. and Ghaffari, K. and Ghafourifard, M. and Ghamari, S.H. and Ghasemi Nour, M. and Ghassemi, F. and Ghimire, A. and Ghith, N. and Gholamalizadeh, M. and Gholizadeh Navashenaq, J. and Ghozy, S. and Gilani, S.A. and Gill, P.S. and Ginindza, T.G. and Gizaw, A.T.T. and Glasbey, J.C. and Godos, J. and Goel, A. and Golechha, M. and Goleij, P. and Golinelli, D. and Golitaleb, M. and Gorini, G. and Goulart, B.N.G. and Grosso, G. and Guadie, H.A. and Gubari, M.I.M. and Gudayu, T.W. and Guerra, M.R. and Gunawardane, D.A. and Gupta, B. and Gupta, S. and Gupta, V.B. and Gupta, V.K. and Gurara, M.K. and Guta, A. and Habibzadeh, P. and Haddadi Avval, A. and Hafezi-Nejad, N. and Hajj Ali, A. and Haj-Mirzaian, A. and Halboub, E.S. and Halimi, A. and Halwani, R. and Hamadeh, R.R. and Hameed, S. and Hamidi, S. and Hanif, A. and Hariri, S. and Harlianto, N.I. and Haro, J.M. and Hartono, R.K. and Hasaballah, A.I. and Hasan, S.M.M. and Hasani, H. and Hashemi, S.M. and Hassan, A.M. and Hassanipour, S. and Hayat, K. and Heidari, G. and Heidari, M. and Heidarymeybodi, Z. and Herrera-Serna, B.Y. and Herteliu, C. and Hezam, K. and Hiraike, Y. and Hlongwa, M.M. and Holla, R. and Holm, M. and Horita, N. and Hoseini, M. and Hossain, M.M. and Hossain, M.B.H. and Hosseini, M.S. and Hosseinzadeh, A. and Hosseinzadeh, M. and Hostiuc, M. and Hostiuc, S. and Househ, M. and Huang, J. and Hugo, F.N. and Humayun, A. and Hussain, S. and Hussein, N.R. and Hwang, B.F. and Ibitoye, S.E. and Iftikhar, P.M. and Ikuta, K.S. and Ilesanmi, O.St. and Ilic, I.M. and Ilic, M.D. and Immurana, M. and Innos, K. and Iranpour, P. and Irham, L.M. and Islam, M.S. and Islam, R.M. and Islami, F. and Ismail, N.E. and Isola, G. and Iwagami, M. and J, L.M. and Jaiswal, A. and Jakovljevic, M. and Jalili, M. and Jalilian, S. and Jamshidi, E. and Jang, S.I. and Jani, C.T. and Javaheri, T. and Jayarajah, U.U. and Jayaram, S. and Jazayeri, S.B. and Jebai, R. and Jemal, B. and Jeong, W. and Jha, R.P. and Jindal, H.A. and John-Akinola, Y.O. and Jonas, J.B. and Joo, T. and Joseph, N. and Joukar, F. and Jozwiak, J.J. and Jürisson, M. and Kabir, A. and Kacimi, S.E.O. and Kadashetti, V. and Kahe, F. and Kakodkar, P.V. and Kalankesh, L.R. and Kalankesh, L.R. and Kalhor, R. and Kamal, V.K. and Kamangar, F. and Kamath, A. and Kanchan, T. and Kandaswamy, E. and Kandel, H. and Kang, H.J. and Kanno, G.G. and Kapoor, N. and Kar, S.S. and Karanth, S.D. and Karaye, I.M. and Karch, A. and Karimi, A. and Kassa, B.G. and Katoto, P.D.M.C. and Kauppila, J.H. and Kaur, H. and Kebede, A.G. and Keikavoosi-Arani, L. and Kejela, G.G. and Kemp Bohan, P.M. and Keramati, M. and Keykhaei, M. and Khajuria, H. and Khan, A. and Khan, A.A.K. and Khan, E.A. and Khan, G. and Khan, M.N. and Khan, M.A.B. and Khanali, J. and Khatab, K. and Khatatbeh, M.M. and Khatib, M.N. and Khayamzadeh, M. and Khayat Kashani, H.R. and Khazeei Tabari, M.A. and Khezeli, M. and Khodadost, M. and Kim, M.S. and Kim, Y.J. and Kisa, A. and Kisa, S. and Klugar, M. and Klugarová, J. and Kolahi, A.A. and Kolkhir, P. and Kompani, F. and Koul, P.A. and Koulmane Laxminarayana, S.L. and Koyanagi, A. and Krishan, K. and Krishnamoorthy, Y. and Kucuk Bicer, B. and Kugbey, N. and Kulimbet, M. and Kumar, A. and Kumar, G.A. and Kumar, N. and Kurmi, O.P. and Kuttikkattu, A. and La Vecchia, C. and Lahiri, A. and Lal, D.K. and Lám, J. and Lan, Q. and Landires, I. and Larijani, B. and Lasrado, S. and Lau, J. and Lauriola, P. and Ledda, C. and Lee, S.W. and Lee, S.W.H. and Lee, W.C. and Lee, Y.Y. and Lee, Y.H. and Legesse, S.M. and Leigh, J. and Leong, E. and Li, M.C. and Lim, S.S. and Liu, G. and Liu, J. and Lo, C.H. and Lohiya, A. and Lopukhov, P.D. and Lorenzovici, L. and Lotfi, M. and Loureiro, J.A. and Lunevicius, R. and Madadizadeh, F. and Mafi, A.R. and Magdeldin, S. and Mahjoub, S. and Mahmoodpoor, A. and Mahmoudi, M. and Mahmoudimanesh, M. and Mahumud, R.A. and Majeed, A. and Majidpoor, J. and Makki, A. and Makris, K.C. and Malakan Rad, E. and Malekpour, M.R. and Malekzadeh, R. and Malik, A.A. and Mallhi, T.H. and Mallya, S.D. and Mamun, M.A. and Manda, A.L. and Mansour-Ghanaei, F. and Mansouri, B. and Mansournia, M.A. and Mantovani, L.G. and Martini, S. and Martorell, M. and Masoudi, S. and Masoumi, S.Z. and Matei, C.N. and Mathews, E. and Mathur, M.R. and Mathur, V. and McKee, M. and Meena, J.K. and Mehmood, K. and Mehrabi Nasab, E. and Mehrotra, R. and Melese, A. and Mendoza, W. and Menezes, R.G. and Mengesha, S.D. and Mensah, L.G. and Mentis, A.F.A. and Mera-Mamián, A.Y.M. and Meretoja, T.J. and Merid, M.W. and Mersha, A.G. and Meselu, B.T. and Meshkat, M. and Mestrovic, T. and Miao Jonasson, J. and Miazgowski, T. and Michalek, I.M. and Mijena, G.F.W. and Miller, T.R. and Mir, S.A. and Mirinezhad, S.K. and Mirmoeeni, S. and Mirza-Aghazadeh-Attari, M. and Mirzaei, H. and Mirzaei, H.R. and Misganaw, A.S. and Misra, S. and Mohammad, K.A. and Mohammadi, E. and Mohammadi, M. and Mohammadian-Hafshejani, A. and Mohammadpourhodki, R. and Mohammed, A. and Mohammed, S. and Mohan, S. and Mohseni, M. and Moka, N. and Mokdad, A.H. and Molassiotis, A. and Molokhia, M. and Momenzadeh, K. and Momtazmanesh, S. and Monasta, L. and Mons, U. and Montasir, A.A. and Montazeri, F. and Montero, A. and Moosavi, M.A. and Moradi, A. and Moradi, Y. and Moradi Sarabi, M. and Moraga, P. and Morawska, L. and Morrison, S.D. and Morze, J. and Mosapour, A. and Mostafavi, E. and Mousavi, S.M. and Mousavi Isfahani, H. and Mousavi Khaneghah, A. and Mpundu-Kaambwa, C. and Mubarik, S. and Mulita, F. and Munblit, D. and Munro, S.B. and Murillo-Zamora, E. and Musa, J. and Nabhan, A.F. and Nagarajan, A.J. and Nagaraju, S.P. and Nagel, G. and Naghipour, M. and Naimzada, M.D. and Nair, T.S. and Naqvi, A.A. and Narasimha Swamy, S. and Narayana, A.I. and Nassereldine, H. and Natto, Z.S. and Nayak, B.P. and Ndejjo, R. and Nduaguba, S.O. and Negash, W.W. and Nejadghaderi, S.A. and Nejati, K. and Neupane Kandel, S. and Nguyen, H.V.N. and Niazi, R.K. and Noor, N.M. and Noori, M. and Noroozi, N. and Nouraei, H. and Nowroozi, A. and Nuñez-Samudio, V. and Nzoputam, C.I. and Nzoputam, O.J. and Oancea, B. and Odukoya, O.O. and Oghenetega, O.B. and Ogunsakin, R.E. and Oguntade, A.S. and Oh, I.H. and Okati-Aliabad, H. and Okekunle, A.P. and Olagunju, A.T. and Olagunju, T.O. and Olakunde, B.O. and Olufadewa, I.L. and Omer, E. and Omonisi, A.E.E. and Ong, S. and Onwujekwe, O.E. and Orru, H. and Otstavnov, S.S. and Oulhaj, A. and Oumer, B. and Owopetu, O.F. and Oyinloye, B.E. and P A, M. and Padron-Monedero, A. and Padubidri, J. and Pakbin, B. and Pakshir, K. and Pakzad, R. and Palicz, T. and Pana, A. and Pandey, A. and Pandey, A. and Pant, S. and Pardhan, S. and Park, E.C. and Park, E.K. and Park, S. and Patel, J. and Pati, S. and Paudel, R. and Paudel, U. and Paun, M. and Pazoki Toroudi, H. and Peng, M. and Pereira, J. and Pereira, R.B. and Perna, S. and Perumalsamy, N. and Pestell, R.G. and Pezzani, R. and Piccinelli, C. and Pillay, J.D. and Piracha, Z.Z. and Pischon, T. and Postma, M.J. and Pourabhari Langroudi, A. and Pourshams, A. and Pourtaheri, N. and Prashant, A. and Qadir, M.M.F. and Quazi Syed, Z. and Rabiee, M. and Rabiee, N. and Radfar, A. and Radhakrishnan, R.A. and Radhakrishnan, V. and Raeisi, M. and Rafiee, A. and Rafiei, A. and Raheem, N. and Rahim, F. and Rahman, M.O. and Rahman, M. and Rahman, M.A. and Rahmani, A.M. and Rahmani, S. and Rahmanian, V. and Rajai, N. and Rajesh, A. and Ram, P. and Ramezanzadeh, K. and Rana, J. and Ranabhat, K. and Ranasinghe, P. and Rao, C.R. and Rao, S.J. and Rashedi, S. and Rashidi, A. and Rashidi, M. and Rashidi, M.M. and Ratan, Z.A. and Rawaf, D.L. and Rawaf, S. and Rawal, L. and Rawassizadeh, R. and Razeghinia, M.S. and Rehman, A.U. and Rehman, I.U. and Reitsma, M.B and Renzaho, A.M.N. and Rezaei, M. and Rezaei, N. and Rezaei, N. and Rezaei, N. and Rezaei, S. and Rezaeian, M. and Rezapour, A. and Riad, A. and Rikhtegar, R. and Rios-Blancas, M. and Roberts, T.J. and Rohloff, P. and Romero-Rodríguez, E. and Roshandel, G. and Rwegerera, G.M. and S, M. and Saber-Ayad, M.M. and Saberzadeh-Ardestani, B. and Sabour, S. and Saddik, B. and Sadeghi, E. and Saeb, M.R. and Saeed, U. and Safaei, M. and Safary, A. and Sahebazzamani, M. and Sahebkar, A. and Sahoo, H. and Sajid, M.R. and Salari, H. and Salehi, S. and Salem, M.R. and Salimzadeh, H. and Samodra, Y.L. and Samy, A.M. and Sanabria, J. and Sankararaman, S. and Sanmarchi, F. and Santric-Milicevic, M.M. and Saqib, M.A.N. and Sarveazad, A. and Sarvi, F. and Sathian, B. and Satpathy, M. and Sayegh, N. and Schneider, I.J.C. and Schwarzinger, M. and Šekerija, M. and Senthilkumaran, S. and Sepanlou, S.G. and Seylani, A. and Seyoum, K. and Sha, F. and Shafaat, O. and Shah, P.A. and Shahabi, S. and Shahid, I. and Shahrbaf, M.A. and Shahsavari, H.R. and Shaikh, M.A. and Shaka, M.F. and Shaker, E. and Shannawaz, M. and Sharew, M.M.S. and Sharifi, A. and Sharifi-Rad, J. and Sharma, P. and Shashamo, B.B. and Sheikh, A. and Sheikh, M. and Sheikhbahaei, S. and Sheikhi, R.A. and Sheikhy, A. and Shepherd, P.R. and Shetty, A. and Shetty, J.K. and Shetty, R.S. and Shibuya, K. and Shirkoohi, R. and Shirzad-Aski, H. and Shivakumar, K.M. and Shivalli, S. and Shivarov, V. and Shobeiri, P. and Shokri Varniab, Z. and Shorofi, S.A. and Shrestha, S. and Sibhat, M.M. and Siddappa Malleshappa, S.K. and Sidemo, N.B. and Silva, D.A.S. and Silva, L.M.L.R. and Silva Julian, G. and Silvestris, N. and Simegn, W. and Singh, A.D. and Singh, A. and Singh, G. and Singh, H. and Singh, J.A. and Singh, J.K. and Singh, P. and Singh, S. and Sinha, D.N. and Sinke, A.H. and Siraj, M.S. and Sitas, F. and Siwal, S.S. and Skryabin, V.Y. and Skryabina, A. A. and Socea, B. and Soeberg, M.J. and Sofi-Mahmudi, A. and Solomon, Y. and Soltani-Zangbar, M.S. and Song, S. and Song, Y. and Sorensen, R.J.D. and Soshnikov, S. and Sotoudeh, H. and Sowe, A. and Sufiyan, M.B. and Suk, R. and Suleman, M. and Suliankatchi Abdulkader, R. and Sultana, S. and Sur, D. and Szócska, M. and Tabaeian, S.P. and Tabarés-Seisdedos, R. and Tabatabaei, S.M. and Tabuchi, T. and Tadbiri, H. and Taheri, E. and Taheri, M. and Taheri Soodejani, M. and Takahashi, K. and Talaat, I.M. and Tampa, M. and Tan, K.K. and Tat, N.Y. and Tat, V.Y. and Tavakoli, A. and Tavakoli, A. and Tehrani-Banihashemi, A. and Tekalegn, Y. and Tesfay, F.H. and Thapar, R. and Thavamani, A. and Thoguluva Chandrasekar, V. and Thomas, N. and Thomas, N.K. and Ticoalu, J.H.V. and Tiyuri, A. and Tollosa, D.N. and Topor-Madry, R. and Touvier, M. and Tovani-Palone, M.R. and Traini, E. and Tran, M.T.N. and Tripathy, J.P. and Ukke, G.G. and Ullah, I. and Ullah, S. and Ullah, S. and Unnikrishnan, B. and Vacante, M. and Vaezi, M. and Valadan Tahbaz, S. and Valdez, P.R. and Vardavas, C. and Varthya, S.B. and Vaziri, S. and Velazquez, D.Z. and Veroux, M. and Villeneuve, P.J. and Violante, F.S. and Vladimirov, S.K. and Vlassov, V. and Vo, B. and Vu, L.G. and Wadood, A.W. and Waheed, Y. and Walde, M.T. and Wamai, R.G. and Wang, C. and Wang, F. and Wang, N. and Wang, Y. and Ward, P. and Waris, A. and Westerman, R. and Wickramasinghe, N.D. and Woldemariam, M. and Woldu, B. and Xiao, H. and Xu, S. and Xu, X. and Yadav, L. and Yahyazadeh Jabbari, S.H. and Yang, L. and Yazdanpanah, F. and Yeshaw, Y. and Yismaw, Y. and Yonemoto, N. and Younis, M.Z. and Yousefi, Z. and Yousefian, F. and Yu, C. and Yu, Y. and Yunusa, I. and Zahir, M. and Zaki, N. and Zaman, B.A. and Zangiabadian, M. and Zare, F. and Zare, I. and Zareshahrabadi, Z. and Zarrintan, A. and Zastrozhin, M.S. and Zeineddine, M.A. and Zhang, D. and Zhang, J. and Zhang, Y. and Zhang, Z.J. and Zhou, L. and Zodpey, S. and Zoladl, M. and Vos, T. and Hay, S.I. and Force, L.M. and Murray, C.J.L.
Lancet 400 (10352): 563-591. 20 August 2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J. and Bartolomaeus, H. and Löber, U. and Behrens, F. and Bartolomaeus, T.U.P. and Anandakumar, H. and Wimmer, M. and Vu, D.L. and Kuhring, M. and Brüning, U. and Maifeld, A. and Geisberger, S. and Kempa, S. and Schumacher, F. and Kleuser, B. and Bufler, P. and Querfeld, U. and Kitschke, S. and Engler, D. and Kuhrt, L. and Drechsel, O. and Eckardt, K.U. and Forslund, S. and Thürmer, A. and McParland, V. and Kirwan, J. and Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology : ASN.2022030378. 19 August 2022 (In Press)

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.
Zhai, Y. and Singh, P. and Dolnik, A. and Brazda, P. and Atlasy, N. and Del Gaudio, N. and Döhner, K. and Döhner, H. and Minucci, S. and Martens, J. and Altucci, L. and Megchelenbrink, W. and Bullinger, L. and Stunnenberg, H.G.
Molecular Cancer 21 (1): 166. 19 August 2022

Acute kidney injury in patients receiving pembrolizumab combination therapy versus pembrolizumab monotherapy for advanced lung cancer.
Gupta, S. and Strohbehn, I.A. and Wang, Q. and Hanna, P.E. and Seethapathy, R. and Prosek, J.M. and Herrmann, S.M. and Abudayyeh, A. and Malik, A.B. and Loew, S. and Carlos, C.A. and Chang, W.T. and Beckerman, P. and Mithani, Z. and Shah, C.V. and Renaghan, A. and de Seigneux, S. and Campedel, L. and Kitchlu, A. and Shin, D.S. and Coppock, G. and Lumlertgul, N. and Garcia, P. and Ortiz-Melo, D.I. and Rashidi, A. and Sprangers, B. and Aggarwal, V. and Benesova, K. and Jhaveri, K.D. and Cortazar, F.B. and Weins, A. and Zuo, Y. and Mooradian, M.J. and Reynolds, K.L. and Leaf, D.E. and Sise, M.E.
Kidney International 11 August 2022 (In Press)

Functional modulation of PTH1R activation and signaling by RAMP2.
Nemec, K. and Schihada, H. and Kleinau, G. and Zabel, U. and Grushevsky, E.O. and Scheerer, P. and Lohse, M.J. and Maiellaro, I.
Proceedings of the National Academy of Sciences of the United States of America 119 (32): e2122037119. 9 August 2022

Reduced splenic uptake on (68)Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis.
Kraus, S. and Klassen, P. and Kircher, M. and Dierks, A. and Habringer, S. and Gäble, A. and Kortüm, K.M. and Weinhold, N. and Ademaj-Kospiri, V. and Werner, R.A. and Schirbel, A. and Buck, A.K. and Herhaus, P. and Wester, H.J. and Rosenwald, A. and Weber, W.A. and Einsele, H. and Keller, U. and Rasche, L. and Lapa, C.
Theranostics 12 (13): 5986-5994. 8 August 2022

Unified classification and risk-stratification in Acute Myeloid Leukemia.
Tazi, Y. and Arango-Ossa, J.E. and Zhou, Y. and Bernard, E. and Thomas, I. and Gilkes, A. and Freeman, S. and Pradat, Y. and Johnson, S.J. and Hills, R. and Dillon, R. and Levine, M.F. and Leongamornlert, D. and Butler, A. and Ganser, A. and Bullinger, L. and Döhner, K. and Ottmann, O. and Adams, R. and Döhner, H. and Campbell, P.J. and Burnett, A.K. and Dennis, M. and Russell, N.H. and Devlin, S.M. and Huntly, B.J.P. and Papaemmanuil, E.
Nature Communications 13 (1): 4622. 8 August 2022

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D. and Lindberg, E.L. and Maatz, H. and Miranda, A.M.A. and Viveiros, A. and Shvetsov, N. and Gärtner, A. and Nadelmann, E.R. and Lee, M. and Kanemaru, K. and Ruiz-Orera, J. and Strohmenger, V. and DeLaughter, D.M. and Patone, G. and Zhang, H. and Woehler, A. and Lippert, C. and Kim, Y. and Adami, E. and Gorham, J.M. and Barnett, S.N. and Brown, K. and Buchan, R.J. and Chowdhury, R.A. and Constantinou, C. and Cranley, J. and Felkin, L.E. and Fox, H. and Ghauri, A. and Gummert, J. and Kanda, M. and Li, R. and Mach, L. and McDonough, B. and Samari, S. and Shahriaran, F. and Yapp, C. and Stanasiuk, C. and Theotokis, P.I. and Theis, F.J. and van den Bogaerdt, A. and Wakimoto, H. and Ware, J.S. and Worth, C.L. and Barton, P.J.R. and Lee, Y.A. and Teichmann, S.A. and Milting, H. and Noseda, M. and Oudit, G.Y. and Heinig, M. and Seidman, J.G. and Hubner, N. and Seidman, C.E.
Science 377 (6606): eabo1984. 5 August 2022

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.
Schepanski, S. and Chini, M. and Sternemann, V. and Urbschat, C. and Thiele, K. and Sun, T. and Zhao, Y. and Poburski, M. and Woestemeier, A. and Thieme, M.T. and Zazara, D.E. and Alawi, M. and Fischer, N. and Heeren, J. and Vladimirov, N. and Woehler, A. and Puelles, V.G. and Bonn, S. and Gagliani, N. and Hanganu-Opatz, I.L. and Arck, P.C.
Nature Communications 13 (1): 4571. 5 August 2022

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska, R. and Mikecin, A.M. and Kaschutnig, P. and Fawaz, M. and Büchler-Schäff, M. and Le, D. and Ganuza, M. and Vollmer, A. and Paffenholz, S.V. and Asada, N. and Rodriguez-Correa, E. and Frauhammer, F. and Buettner, F. and Ball, M. and Knoch, J. and Stäble, S. and Walter, D. and Petri, A. and Carreño-Gonzalez, M.J. and Wagner, V. and Brors, B. and Haas, S. and Lipka, D.B. and Essers, M.A.G. and Weru, V. and Holland-Letz, T. and Mallm, J.P. and Rippe, K. and Krämer, S. and Schlesner, M. and McKinney Freeman, S. and Florian, M.C. and King, K.Y. and Frenette, P.S. and Rieger, M.A. and Milsom, M.D.
Cell Stem Cell 29 (8): 1273-1284.e8. 4 August 2022

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto, M. and Kaminski, M.M. and Adrianus, C. and Kim, N. and Greensmith, R. and Dissanayake-Perera, S. and Schubert, A.J. and Tan, X. and Kim, H. and Dighe, A.S. and Collins, J.J. and Stevens, M.M.
Nature Nanotechnology 4 August 2022 (In Press)

A high-resolution map of human RNA translation.
Chothani, S.P. and Adami, E. and Widjaja, A.A. and Langley, S.R. and Viswanathan, S. and Pua, C.J. and Zhihao, N.T. and Harmston, N. and D'Agostino, G. and Whiffin, N. and Mao, W. and Ouyang, J.F. and Lim, W.W. and Lim, S. and Lee, C.Q.E. and Grubman, A. and Chen, J. and Kovalik, J.P. and Tryggvason, K. and Polo, J.M. and Ho, L. and Cook, S.A. and Rackham, O.J.L. and Schafer, S.
Molecular Cell 82 (15): 2885-2899.e8. 4 August 2022

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
Letizia, M. and Wang, Y.H. and Kaufmann, U. and Gerbeth, L. and Sand, A. and Brunkhorst, M. and Weidner, P. and Ziegler, J.F. and Böttcher, C. and Schlickeiser, S. and Fernández, C. and Yamashita, M. and Stauderman, K. and Sun, K. and Kunkel, D. and Prakriya, M. and Sanders, A.D. and Siegmund, B. and Feske, S. and Weidinger, C.
EMBO Molecular Medicine : e15687. 2 August 2022

Nonproductive exposure of PBMCs to SARS‐CoV ‐2 induces cell‐intrinsic innate immune responses.
Kazmierski, J. and Friedmann, K. and Postmus, D. and Emanuel, J. and Fischer, C. and Jansen, J. and Richter, A. and Bosquillon de Jarcy, L. and Schüler, C. and Sohn, M. and Sauer, S. and Drosten, C. and Saliba, A.E. and Sander, L.E. and Müller, M.A. and Niemeyer, D. and Goffinet, C.
Molecular Systems Biology 18 (8): e10961. 1 August 2022

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
Grasedieck, S. and Cabantog, A. and MacPhee, L. and Im, J. and Ruess, C. and Demir, B. and Sperb, N. and Rücker, F.G. and Döhner, K. and Herold, T. and Pollack, J.R. and Bullinger, L. and Rouhi, A. and Kuchenbauer, F.
Haematologica 107 (8): 1758-1772. August 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B. and Lelek, S. and Spanjaard, B. and El-Sammak, H. and Simões, M.G. and Mintcheva, J. and Aliee, H. and Schäfer, R. and Meyer, A.M. and Theis, F. and Stainier, D.Y.R. and Panáková, D. and Junker, J.P.
Nature Genetics 54 (8): 1227-1237. August 2022

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
Ihlow, J. and Gross, S. and Busack, L. and Flörcken, A. and Jesse, J. and Schwarz, M. and Neuendorff, N.R. and von Brünneck, A.C. and Anagnostopoulos, I. and Türkmen, S. and Blau, I.W. and Burmeister, T. and Horst, D. and Bullinger, L. and Westermann, J.
Haematologica 107 (8): 1773-1785. August 2022

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K. and Mensch, J. and Grimmig, M.E. and Neuner, B. and Gorzelniak, K. and Türkmen, S. and Demuth, I. and Hartmann, A. and Hartmann, C. and Wittig, F. and Sporbert, A. and Hermann, A. and Fuellen, G. and Möller, S. and Walter, M.
Science Advances 8 (33): eabk2814. August 2022

Deep Visual Proteomics defines single-cell identity and heterogeneity.
Mund, A. and Coscia, F. and Kriston, A. and Hollandi, R. and Kovács, F. and Brunner, A.D. and Migh, E. and Schweizer, L. and Santos, A. and Bzorek, M. and Naimy, S. and Rahbek-Gjerdrum, L.M. and Dyring-Andersen, B. and Bulkescher, J. and Lukas, C. and Eckert, M.A. and Lengyel, E. and Gnann, C. and Lundberg, E. and Horvath, P. and Mann, M.
Nature Biotechnology 40 (8): 1231-1240. August 2022

CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A. and Sonnemann, J. and Amann, K. and Mildner, A. and Lodka, D. and Kling, L. and Bieringer, M. and Schneider, U. and Leutz, A. and Enghard, P. and Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
Schmid, V.K. and Khadour, A. and Ahmed, N. and Brandl, C. and Nitschke, L. and Rajewsky, K. and Jumaa, H. and Hobeika, E.
Haematologica 107 (8): 1796-1814. August 2022

The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
Viñado, A.C. and Calvo, I.A. and Cenzano, I. and Olaverri, D. and Cocera, M. and San Martin-Uriz, P. and Romero, J.P. and Vilas-Zornoza, A. and Vera, L. and Gomez-Cebrian, N. and Puchades-Carrasco, L. and Lisi-Vega, L.E. and Apaolaza, I. and Valera, P. and Guruceaga, E. and Granero-Molto, F. and Ripalda-Cemborain, P. and Luck, T.J. and Bullinger, L. and Planes, F.J. and Rifon, J.J. and Méndez-Ferrer, S. and Yusuf, R.Z. and Pardo-Saganta, A. and Prosper, F. and Saez, B.
Leukemia 36 (8): 1969-1979. August 2022

Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C. and Maghsudi, S. and Ohler, U.
Nucleic Acids Research : gkac639. 31 July 2022 (In Press)

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G. and Bartolomaeus, H. and Rauch, A. and Chen, C.Y. and N'Diaye, G. and Löber, U. and Bartolomaeus, T.U.P. and Fritsche-Guenther, R. and Rodrigues, A.F. and Yarritu, A. and Zhong, C. and Fei, L. and Tsvetkov, D. and Todiras, M. and Park, J.K. and Markó, L. and Maifeld, A. and Patzak, A. and Bader, M. and Kempa, S. and Kirwan, J.A. and Forslund, S.K. and Müller, D.N. and Wilck, N.
Cardiovascular Research : cvac121. 29 July 2022 (In Press)

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. and Pusch, F. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Guillan, K. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Meyer-Liesener, S. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Dubois, F. and Horst, D. and Schulte, J.H. and Spuler, S. and You, D. and Dela Cruz, F. and Kung, A.L. and Haase, K. and Di Virgilio, M. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: A joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial & Pericardial Diseases.
Gyöngyösi, M. and Alcaide, P. and Asselbergs, F.W. and Brundel, B.J.J.M. and Camici, G.G. and da Costa Martins, P. and Ferdinandy, P. and Fontana, M. and Girao, H. and Gnecchi, M. and Gollmann-Tepeköylü, C. and Kleinbongard, P. and Krieg, T. and Madonna, R. and Paillard, M. and Pantazis, A. and Perrino, C. and Pesce, M. and Schiattarella, G.G. and Sluijter, J.P.G. and Steffens, S. and Tschöpe, C. and Van Linthout, S. and Davidson, S.M.
Cardiovascular Research : cvac115. 25 July 2022 (In Press)

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, S. and Hurdiss, D.L. and Walser, M. and Malvezzi, F. and Mayor, J. and Ryter, S. and Moreno, H. and Liechti, N. and Bosshart, A. and Iss, C. and Calabro, V. and Cornelius, A. and Hospodarsch, T. and Neculcea, A. and Looser, T. and Schlegel, A. and Fontaine, S. and Villemagne, D. and Paladino, M. and Schiegg, D. and Mangold, S. and Reichen, C. and Radom, F. and Kaufmann, Y. and Schaible, D. and Schlegel, I. and Zitt, C. and Sigrist, G. and Straumann, M. and Wolter, J. and Comby, M. and Sacarcelik, F. and Drulyte, I. and Lyoo, H. and Wang, C. and Li, W. and Du, W. and Binz, H.K. and Herrup, R. and Lusvarghi, S. and Neerukonda, S.N. and Vassell, R. and Wang, W. and Adler, J.M. and Eschke, K. and Nascimento, M. and Abdelgawad, A. and Gruber, A.D. and Bushe, J. and Kershaw, O. and Knutson, C.G. and Balavenkatraman, K.K. and Ramanathan, K. and Wyler, E. and Teixeira Alves, L.G. and Lewis, S. and Watson, R. and Haeuptle, M.A. and Zürcher, A. and Dawson, K.M. and Steiner, D. and Weiss, C.D. and Amstutz, P. and van Kuppeveld, F.J.M. and Stumpp, M.T. and Bosch, B.J. and Engler, O. and Trimpert, J.
Nature Biotechnology 21 July 2022 (In Press)

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
Conte, M. and Irani, E. and Chiariello, A.M. and Abraham, A. and Bianco, S. and Esposito, A. and Nicodemi, M.
Nature Communications 13 (1): 4070. 13 July 2022

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja, A. and Wakimoto, H. and DeLaughter, D.M. and Reichart, D. and Gorham, J. and Conner, D.A. and Lun, M. and Probst, C.K. and Sakai, N. and Knipe, R.S. and Montesi, S.B. and Shea, B. and Adam, L.P. and Leinwand, L.A. and Wan, W. and Choi, E.S. and Lindberg, E.L. and Patone, G. and Noseda, M. and Hübner, N. and Seidman, C.E. and Tager, A.M. and Seidman, J.G. and Ho, C.Y.
Proceedings of the National Academy of Sciences of the United States of America 119 (28): e2204174119. 12 July 2022

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A. and Bunse, M. and Joedicke, J.J. and Blanc, E. and Gudipati, V. and Moles, M.W. and Shiku, H. and Beule, D. and Huppa, J.B. and Höpken, U.E. and Rehm, A.
Molecular Therapy 12 July 2022 (In Press)

Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
Hesse, J. and Schleimer, J.H. and Maier, N. and Schmitz, D. and Schreiber, S.
Nature Communications 13 (1): 3934. 8 July 2022

Biosynthetic potential of the global ocean microbiome.
Paoli, L. and Ruscheweyh, H.J. and Forneris, C.C. and Hubrich, F. and Kautsar, S. and Bhushan, A. and Lotti, A. and Clayssen, Q. and Salazar, G. and Milanese, A. and Carlström, C.I. and Papadopoulou, C. and Gehrig, D. and Karasikov, M. and Mustafa, H. and Larralde, M. and Carroll, L.M. and Sánchez, P. and Zayed, A.A. and Cronin, D.R. and Acinas, S.G. and Bork, P. and Bowler, C. and Delmont, T.O. and Gasol, J.M. and Gossert, A.D. and Kahles, A. and Sullivan, M.B. and Wincker, P. and Zeller, G. and Robinson, S.L. and Piel, J. and Sunagawa, S.
Nature 607 (7917): 111–118. 7 July 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J. and Müllerke, S. and Kolesnichenko, M. and Heuberger, J. and Lin, M. and Fischer, A.S. and Mollenkopf, H.J. and Berger, H. and Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I. and Planells-Cases, R. and Pietzke, M. and Oliveras, A. and Kempa, S. and Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 1 July 2022 (In Press)

Whole-body magnetic resonance imaging in the large population-based German National Cohort study: predictive capability of automated image quality assessment for protocol repetitions.
Schuppert, C. and von Krüchten, R. and Hirsch, J.G. and Rospleszcz, S. and Hoinkiss, D.C. and Selder, S. and Köhn, A. and von Stackelberg, O. and Peters, A. and Völzke, H. and Kröncke, T. and Niendorf, T. and Forsting, M. and Hosten, N. and Hendel, T. and Pischon, T. and Jöckel, K.H. and Kaaks, R. and Bamberg, F. and Kauczor, H.U. and Günther, M. and Schlett, C.L.
Investigative Radiology 57 (7): 478-487. 1 July 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. and Acemel, R.D. and Jedamzick, J. and Bolondi, A. and Cova, G. and Brieske, N. and Kühn, R. and Wittler, L. and Real, F.M. and Lupiáñez, D.G.
Nature Genetics July 2022

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D. and Hörtenhuber, M. and Balwierz, P.J. and Zehnder, T. and Mukarram, A.K. and Nepal, C. and Várnai, C. and Hadzhiev, Y. and Jimenez-Gonzalez, A. and Li, N. and Wragg, J. and D'Orazio, F.M. and Relic, D. and Pachkov, M. and Díaz, N. and Hernández-Rodríguez, B. and Chen, Z. and Stoiber, M. and Dong, M. and Stevens, I. and Ross, S.E. and Eagle, A. and Martin, R. and Obasaju, O. and Rastegar, S. and McGarvey, A.C. and Kopp, W. and Chambers, E. and Wang, D. and Kim, H.R. and Acemel, R.D. and Naranjo, S. and Łapiński, M. and Chong, V. and Mathavan, S. and Peers, B. and Sauka-Spengler, T. and Vingron, M. and Carninci, P. and Ohler, U. and Lacadie, S.A. and Burgess, S.M. and Winata, C. and van Eeden, F. and Vaquerizas, J.M. and Gómez-Skarmeta, J.L. and Onichtchouk, D. and Brown, B.J. and Bogdanovic, O. and van Nimwegen, E. and Westerfield, M. and Wardle, F.C and Daub, C.O. and Lenhard, B. and Müller, F.
Nature Genetics 54 (7): 1037-1050. July 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M. and Schaupp, A.L. and Sun, R. and Coscia, F. and Dendrou, C.A. and Cortes, A. and Kaur, G. and Evans, H.G. and Mollbrink, A. and Navarro, J.F. and Sonner, J.K. and Mayer, C. and DeLuca, G.C. and Lundeberg, J. and Matthews, P.M. and Attfield, K.E. and Friese, M.A. and Mann, M. and Fugger, L.
Nature Neuroscience 25 (7): 944-955. July 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K. and Obermayer, B. and Mache, C. and Fathykova, D. and Kessler, M. and Dökel, S. and Wyler, E. and Baumgardt, M. and Löwa, A. and Hoffmann, K. and Graff, P. and Schulze, J. and Mieth, M. and Hellwig, K. and Demir, Z. and Biere, B. and Brunotte, L. and Mecate-Zambrano, A. and Bushe, J. and Dohmen, M. and Hinze, C. and Elezkurtaj, S. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Schmidt-Ott, K.M. and Busch, J. and Klauschen, F. and Horst, D. and Radbruch, H. and Radke, J. and Heppner, F. and Corman, V.M. and Niemeyer, D. and Müller, M.A. and Goffinet, C. and Mothes, R. and Pascual-Reguant, A. and Hauser, A.E. and Beule, D. and Landthaler, M. and Ludwig, S. and Suttorp, N. and Witzenrath, M. and Gruber, A.D. and Drosten, C. and Sander, L.E. and Wolff, T. and Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 21 June 2022 (In Press)

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
Pardo, M. and Offer, S. and Hartner, E. and Di Bucchianico, S. and Bisig, C. and Bauer, S. and Pantzke, J. and Zimmermann, E.J. and Cao, X. and Binder, S. and Kuhn, E. and Huber, A. and Jeong, S. and Käfer, U. and Schneider, E. and Mesceriakovas, A. and Bendl, J. and Brejcha, R. and Buchholz, A. and Gat, D. and Hohaus, T. and Rastak, N. and Karg, E. and Jakobi, G. and Kalberer, M. and Kanashova, T. and Hu, Y. and Ogris, C. and Marsico, A. and Theis, F. and Shalit, T. and Gröger, T. and Rüger, C.P. and Oeder, S. and Orasche, J. and Paul, A. and Ziehm, T. and Zhang, Z.H. and Adam, T. and Sippula, O. and Sklorz, M. and Schnelle-Kreis, J. and Czech, H. and Kiendler-Scharr, A. and Zimmermann, R. and Rudich, Y.
Environment International 166 : 107366. 21 June 2022 (In Press)

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B. and Marenholz, I. and Jeanrenaud, A.C. and Meixner, L. and Arnau-Soler, A. and Rosillo-Salazar, O.D. and Ghauri, A. and Cibin, P. and Blümchen, K. and Schlags, R. and Hansen, G. and Seidenberg, J. and Keil, T. and Lau, S. and Niggemann, B. and Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 15 June 2022 (In Press)

mRNA-mediated delivery of gene editing tools to human primary muscle stem cells.
Stadelmann, C. and Di Francescantonio, S. and Marg, A. and Müthel, S. and Spuler, S. and Escobar, H.
Molecular Therapy - Nucleic Acids 28 : 47-57. 14 June 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M. and Tucker, E. and Dorel, M. and Winkler, A. and McGearey, A. and Rodriguez-Fos, E. and da Costa, B.M. and Barker, K. and Fyle, E. and Calton, E. and Eising, S. and Ober, K. and Hughes, D. and Koutroumanidou, E. and Carter, P. and Stankunaite, R. and Proszek, P. and Jain, N. and Rosswog, C. and Dorado-Garcia, H. and Molenaar, J.J. and Hubank, M. and Barone, G. and Anderson, J. and Lang, P. and Deubzer, H.E. and Künkele, A. and Fischer, M. and Eggert, A. and Kloft, C. and Henssen, A.G. and Boettcher, M. and Hertwig, F. and Blüthgen, N. and Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L. and Pick, R. and Montorfani, J. and Sun, M. and Brighouse, D. and Liaudet, N. and Kammertoens, T. and Blankenstein, T. and Page, N. and Bernier-Latamani, J. and Tran, N.L. and Petrova, T.V. and Merkler, D. and Scheiermann, C. and Hugues, S.
Science Advances 8 (23): eabl5162. 8 June 2022

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal, E. and Schmidt, T.S.B. and Molina-Montes, E. and Rodríguez-Perales, S. and Wirbel, J. and Maistrenko, O.M. and Akanni, W.A. and Alashkar Alhamwe, B. and Alves, R.J. and Carrato, A. and Erasmus, H.P. and Estudillo, L. and Finkelmeier, F. and Fullam, A. and Glazek, A.M. and Gómez-Rubio, P. and Hercog, R. and Jung, F. and Kandels, S. and Kersting, S. and Langheinrich, M. and Márquez, M. and Molero, X. and Orakov, A. and Van Rossum, T. and Torres-Ruiz, R. and Telzerow, A. and Zych, K. and Benes, V. and Zeller, G. and Trebicka, J. and Real, F.X. and Malats, N. and Bork, P.
Gut 71 (7): 1359-1372. 7 June 2022

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L. and Dempsey, B. and Garancher, A. and Bourane, S. and Ruffault, P.L. and Morin-Surun, M.P. and Rocques, N. and Goulding, M. and Eychène, A. and Pouponnot, C. and Fortin, G. and Champagnat, J.
Nature Communications 13 (1): 3284. 7 June 2022

The role of intraspinal sensory neurons in the control of quadrupedal locomotion.
Gerstmann, K. and Jurčić, N. and Blasco, E. and Kunz, S. and de Almeida Sassi, F. and Wanaverbecq, N. and Zampieri, N.
Current Biology 32 (11): 2442-2453. 6 June 2022

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y. and Du Jiang, P. and Chao, B.N. and Cagdas, D. and Kubo, S. and Balasubramaniyam, A. and Zhang, Y. and Shadur, B. and NaserEddin, A. and Folio, L.R. and Schwarz, B. and Bohrnsen, E. and Zheng, L. and Lynberg, M. and Gottlieb, S. and Leney-Greene, M.A. and Park, A.Y. and Tezcan, I. and Akdogan, A. and Gocmen, R. and Onder, S. and Rosenberg, A. and Soilleux, E.J. and Johnson, E. and Jackson, P.K. and Demeter, J. and Chauvin, S.D. and Paul, F. and Selbach, M. and Bulut, H. and Clatworthy, M.R. and Tuong, Z.K. and Zhang, H. and Stewart, B.J. and Bosio, C.M. and Stepensky, P. and Clare, S. and Ganesan, S. and Pascall, J.C. and Daumke, O. and Butcher, G.W. and McMichael, A.J. and Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219 (6): e20201405. 6 June 2022

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. and Danner, E. and Li, X. and Graf, R. and Lebedin, M. and de la Rosa, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022

The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K. and Kirchner, M. and Mertins, P. and Zuberbier, T. and Babina, M.
Allergy 2 June 2022 (In Press)

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H. and Dauksaite, V. and Sporbert, A. and Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083.e8. 2 June 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T.L.. and Löhning, M.
Nature Communications 13 (1): 3059. 1 June 2022

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum, R. and Suwalski, P. and Asgharian, H. and Du Zhipei, G. and Lin, H. and Weiner, J. and Holtgrewe, M. and Thibeault, C. and Müller, M. and Wang, X. and Karadeniz, Z. and Saccomanno, J. and Doehn, J.M. and Hübner, R.H. and Hinzmann, B. and Blüher, A. and Siemann, S. and Telman, D. and Suttorp, N. and Witzenrath, M. and Hippenstiel, S. and Skurk, C. and Poller, W. and Sander, L.E. and Beule, D. and Kurth, F. and Guettouche, T. and Landmesser, U. and Berka, J. and Luong, K. and Rubelt, F. and Heidecker, B.
EClinicalMedicine 48 : 101438. June 2022

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong, Y.T. and Andrade, J. and Armbruster, M. and Shi, C. and Castro, M. and Costa, A.S.H. and Sugino, T. and Eelen, G. and Zimmermann, B. and Wilhelm, K. and Lim, J. and Watanabe, S. and Guenther, S. and Schneider, A. and Zanconato, F. and Kaulich, M. and Pan, D. and Braun, T. and Gerhardt, H. and Efeyan, A. and Carmeliet, P. and Piccolo, S. and Grosso, A.R. and Potente, M.
Nature Metabolism 4 (6): 672–682. June 2022

Proton-gated anion transport governs macropinosome shrinkage.
Zeziulia, M. and Blin, S. and Schmitt, F.W. and Lehmann, M. and Jentsch, T.J.
Nature Cell Biology 24 (6): 885-895. June 2022

Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J. and Baranovskii, A. and Ronen, J. and Uyar, B. and Franke, V. and Akalin, A.
Genome Biology 23 (1): 123. 30 May 2022

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran, D. and Kochlamazashvili, G. and Pampaloni, N. P. and Sposini, S. and Shergill, J.K. and Lehmann, M. and Pashkova, N. and Schmidt, C. and Löwe, D. and Napieczynska, H. and Heuser, A. and Plested, A.J.R. and Perrais, D. and Piper, R.C. and Haucke, V. and Maritzen, T.
Science Advances 8 (21): eabl5032. 27 May 2022

Best practice standards for circular RNA research.
Nielsen, A.F. and Bindereif, A. and Bozzoni, I. and Hanan, M. and Hansen, T.B. and Irimia, M. and Kadener, S. and Kristensen, L.S. and Legnini, I. and Morlando, M. and Jarlstad Olesen, M.T. and Pasterkamp, R.J. and Preibisch, S. and Rajewsky, N. and Suenkel, C. and Kjems, J.
Nature Methods 26 May 2022 (In Press)

Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
Porubsky, D. and Höps, W. and Ashraf, H. and Hsieh, P.H. and Rodriguez-Martin, B. and Yilmaz, F. and Ebler, J. and Hallast, P. and Maggiolini, F.A.M. and Harvey, W.T. and Henning, B. and Audano, P.A. and Gordon, D.S. and Ebert, P. and Hasenfeld, P. and Benito, E. and Zhu, Q. and Lee, C. and Antonacci, F. and Steinrücken, M. and Beck, C.R. and Sanders, A.D. and Marschall, T. and Eichler, E.E. and Korbel, J.O.
Cell 185 (11): 1986-2005.e26. 26 May 2022

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz, C. and Benson, G.S. and Horn, N. and Wurdack, K. and Grittner, U. and Schilling, R. and Märschenz, S. and Köbe, T. and Hofer, S.J. and Magnes, C. and Stekovic, S. and Eisenberg, T. and Sigrist, S.J. and Schmitz, D. and Wirth, M. and Madeo, F. and Flöel, A.
JAMA Network Open 5 (5): e2213875. 26 May 2022

Serotonin limits generation of chromaffin cells during adrenal organ development.
Kameneva, P. and Melnikova, V.I. and Kastriti, M.E. and Kurtova, A. and Kryukov, E. and Murtazina, A. and Faure, L. and Poverennaya, I. and Artemov, A.V. and Kalinina, T.S. and Kudryashov, N.V. and Bader, M. and Skoda, J. and Chlapek, P. and Curylova, L. and Sourada, L. and Neradil, J. and Tesarova, M. and Pasqualetti, M. and Gaspar, P. and Yakushov, V.D. and Sheftel, B.I. and Zikmund, T. and Kaiser, J. and Fried, K. and Alenina, N. and Voronezhskaya, E.E. and Adameyko, I.
Nature Communications 13 (1): 2901. 25 May 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U. and Milek, M. and Minia, I. and Vieira-Vieira, C.H. and Müller, S. and Mastrobuoni, G. and Hazapis, O.G. and Del Giudice, S. and Schwefel, D. and Bley, N. and Voigt, F. and Chao, J.A. and Kempa, S. and Hüttelmaier, S. and Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

Brain-wide interactions during hippocampal sharp wave ripples.
Nitzan, N. and Swanson, R. and Schmitz, D. and Buzsáki, G.
Proceedings of the National Academy of Sciences of the United States of America 119 (20): e2200931119. 17 May 2022

The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.
Rejeski, K. and Perez, A. and Iacoboni, G. and Penack, O. and Bücklein, V. and Jentzsch, L. and Mougiakakos, D. and Johnson, G. and Arciola, B. and Carpio, C. and Blumenberg, V. and Hoster, E. and Bullinger, L. and Locke, F.L. and von Bergwelt-Baildon, M. and Mackensen, A. and Bethge, W. and Barba, P. and Jain, M.D. and Subklewe, M.
Journal for ImmunoTherapy of Cancer 10 (5): e004475. 17 May 2022

Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
Boogerd, C.J. and Lacraz, G.P.A. and Vértesy, Á. and van Kampen, S.J. and Perini, I. and de Ruiter, H. and Versteeg, D. and Brodehl, A. and van der Kraak, P. and Giacca, M. and de Jonge, N. and Junker, J.P. and van Oudenaarden, A. and Vink, A. and van Rooij, E.
Cardiovascular Research 16 May 2022 (In Press)

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H. and Major, J.L. and Liebner, T. and Hourani, Z. and Travers, J.G. and Wennersten, S.A. and Haefner, K.R. and Cavasin, M.A. and Wilson, C.E. and Jeong, M.Y. and Han, Y. and Gotthardt, M. and Ferguson, S.K. and Ambardekar, A.V. and Lam, M.P. and Choudhary, C. and Granzier, H.L. and Woulfe, K.C. and McKinsey, T.A.
Journal of Clinical Investigation 132 (10): e148333. 16 May 2022

The genomic and transcriptional landscape of primary central nervous system lymphoma.
Radke, J. and Ishaque, N. and Koll, R. and Gu, Z. and Schumann, E. and Sieverling, L. and Uhrig, S. and Hübschmann, D. and Toprak, U.H. and López, C. and Hostench, X.P. and Borgoni, S. and Juraeva, D. and Pritsch, F. and Paramasivam, N. and Balasubramanian, G.P. and Schlesner, M. and Sahay, S. and Weniger, M. and Pehl, D. and Radbruch, H. and Osterloh, A. and Korfel, A. and Misch, M. and Onken, J. and Faust, K. and Vajkoczy, P. and Moskopp, D. and Wang, Y. and Jödicke, A. and Trümper, L. and Anagnostopoulos, I. and Lenze, D. and Küppers, R. and Hummel, M. and Schmitt, C.A. and Wiestler, O.D. and Wolf, S. and Unterberg, A. and Eils, R. and Herold-Mende, C. and Brors, B. and Siebert, R. and Wiemann, S. and Heppner, F.L.
Nature Communications 13 (1): 2558. 10 May 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P. and Vonficht, D. and Schnell, A. and Uckelmann, H.J. and Bollhagen, A. and Mahmoud, M.A.A. and Landua, S.L. and van der Salm, E. and Trautmann, C. and Raffel, S. and Grünschläger, F. and Lutz, R. and Ghosh, M. and Renders, S. and Correia, N. and Donato, E. and Dixon, K.O. and Hirche, C. and Andresen, C. and Robens, Cl. and Werner, P.S. and Boch, T. and Eisel, D. and Osen, W. and Pilz, F. and Przybylla, A. and Klein, C. and Buchholz, F. and Milsom, M.D. and Essers, M.A.G. and Eichmüller, S.B. and Hofmann, W.K. and Nowak, D. and Hübschmann, D. and Hundemer, M. and Thiede, C. and Bullinger, L. and Müller-Tidow, C. and Armstrong, S.A. and Trumpp, A. and Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29 (5): 760-775.e10. 5 May 2022

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler, E. and Adler, J.M. and Eschke, K. and Teixeira Alves, G. and Peidli, S. and Pott, F. and Kazmierski, J. and Michalick, L. and Kershaw, O. and Bushe, J. and Andreotti, S. and Pennitz, P. and Abdelgawad, A. and Postmus, D. and Goffinet, C. and Kreye, J. and Reincke, S.M. and Prüss, H. and Blüthgen, N. and Gruber, A.D. and Kuebler, W.M. and Witzenrath, M. and Landthaler, M. and Nouailles, G. and Trimpert, J.
Molecular Therapy 30 (5): 1952-1965. 4 May 2022

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M. and Böger, M. and Yousefian, S. and Grunert, C. and Zhang, L. and Hotz, P.W. and Gottschlich, A. and Köse, H. and Isaakidis, K. and Vonficht, D. and Grünschläger, F. and Rohleder, E. and Wagner, K. and Dönig, J. and Igl, V. and Brzezicha, B. and Baumgartner, F. and Habringer, S. and Löber, J. and Chapuy, B. and Weidinger, C. and Kobold, S. and Haas, S. and Busse, A.B. and Müller, S. and Wirth, M. and Schick, M. and Keller, U.
Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

Association of maintenance intravenous immunoglobulin with prevention of relapse in adult myelin oligodendrocyte glycoprotein antibody-associated disease.
Chen, J.J. and Huda, S. and Hacohen, Y. and Levy, M. and Lotan, I. and Wilf-Yarkoni, A. and Stiebel-Kalish, H. and Hellmann, M.A. and Sotirchos, E.S. and Henderson, A.D. and Pittock, S.J. and Bhatti, M.T. and Eggenberger, E.R. and Di Nome, M. and Kim, H.J. and Kim, S.H. and Saiz, A. and Paul, F. and Dale, R.C. and Ramanathan, S. and Palace, J. and Camera, V. and Leite, M.I. and Lam, B.L. and Bennett, J.L. and Mariotto, S. and Hodge, D. and Audoin, B. and Maillart, E. and Deschamps, R. and Pique, J. and Flanagan, E.P. and Marignier, R.
JAMA Neurology 79 (5): 518-525. 1 May 2022

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation.
Blassberg, R. and Patel, H. and Watson, T. and Gouti, M. and Metzis, V. and Delás, M.J. and Briscoe, J.
Nature Cell Biology 24 (5): 633-644. May 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H. and Flórez, A.F. and Kreth, S. and Brückner, L.M. and Yildiz, U. and Gartlgruber, M. and Odoni, D.I. and Poschet, G. and Garbowicz, K. and Shao, C. and Klein, C. and Meier, J. and Zeisberger, P. and Nadler-Holly, M. and Ziehm, M. and Paul, F. and Burhenne, J. and Bell, E. and Shaikhkarami, M. and Würth, R. and Stainczyk, S.A. and Wecht, E.M. and Kreth, J. and Büttner, M. and Ishaque, N. and Schlesner, M. and Nicke, B. and Stresemann, C. and Llamazares-Prada, M. and Reiling, J.H. and Fischer, M. and Amit, I. and Selbach, M. and Herrmann, C. and Wölfl, S. and Henrich, K.O. and Höfer, T. and Trumpp, A. and Westermann, F.
Nature Cancer 3 (4): 471-485. 28 April 2022

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase in B cell lymphomas.
Lopez, C. and Schleussner, N. and Bernhart, S.H. and Kleinheinz, K. and Sungalee, S. and Sczakiel, H.L. and Kretzmer, H. and Toprak, U.H. and Glaser, S. and Wagener, R. and Ammerpohl, O. and Bens, S. and Giefing, M. and Sanchez, J.C.G. and Apic, G. and Hubschmann, D. and Janz, M. and Kreuz, M. and Mottok, A. and Müller, J.M. and Seufert, J. and Hoffmann, S. and Korbel, J.O. and Russell, R.B. and Schule, R. and Trumper, L. and Klapper, W. and Radlwimmer, B. and Lichter, P. and Kuppers, R. and Schlesner, M. and Mathas, S. and Siebert, R.
Haematologica 28 April 2022 (In Press)

Antibiotic resistance genes in river biofilms: a metagenomic approach toward the identification of sources and candidate hosts.
Kneis, D. and Berendonk, T.U. and Forslund, S.K. and Hess, S.
Environmental Science and Technology 25 April 2022 (In Press)

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.
Greco, T.M. and Secker, C. and Silva Ramos, E. and Federspiel, J.D. and Liu, J.P. and Perez, A.M. and Al-Ramahi, I. and Cantle, J.P. and Carroll, J.B. and Botas, J. and Zeitlin, S.O. and Wanker, E.E. and Cristea, I.M.
Cell Systems 13 (4): 304-320.e5. 22 April 2022

Hypothalamic galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop.
Corradi, L. and Bruzzone, M. and Maschio, M.D. and Sawamiphak, S. and Filosa, A.
Current Biology 32 (7): 1497-1510. 11 April 2022

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S. and Smyshlyaev, G. and Letunic, I. and Maistrenko, O.M. and Coelho, L.P. and Orakov, A. and Forslund, S.K. and Hildebrand, F. and Luetge, M. and Schmidt, T.S.B. and Barabas, O. and Bork, P.
Nucleic Acids Research 50 (6): 3155-3168. 8 April 2022

Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T. and Himmerkus, N. and Meoli, L. and Fromm, A. and Sewerin, S. and Kriuchkova, N. and Nagel, O. and Ladilov, Y. and Krug, S. and Quintanova, C. and Stumpp, M. and Garbe-Schönberg, D. and Westernströer, U. and Merkel, C. and Brinkhus, M. and Altmüller, J. and Schweiger, M. and Mueller, D. and Mutig, K. and Morawski, M. and Halbritter, J. and Milatz, S. and Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33 (4): 699-717. April 2022

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Christen, F. and Hablesreiter, R. and Hoyer, K. and Hennch, C. and Maluck-Böttcher, A. and Segler, A. and Madadi, A. and Frick, M. and Bullinger, L. and Briest, F. and Damm, F.
Leukemia 36 (4): 1102-1110. April 2022

Statistical analysis in the German National Cohort (NAKO) - specific aspects and general recommendations.
Kuss, O. and Becher, H. and Wienke, A. and Ittermann, T. and Ostrzinski, S. and Schipf, S. and Schmidt, C.O. and Leitzmann, M. and Pischon, T. and Krist, L. and Roll, S. and Sand, M. and Pohlabeln, H. and Rach, S. and Jöckel, K.H. and Stang, A. and Mueller, U.A. and Werdecker, A. and Westerman, R. and Greiser, K.H. and Michels, K.B.
European Journal of Epidemiology 37 (4): 429-436. April 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D. and Oshima, M. and Stange, D.E. and Sigal, M.
Gastroenterology 162 (4): 1067-1087. April 2022

A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome.
Widjaja, A.A. and Shekeran, S. and Adami, E. and Goh, J. and Tan, J. and Viswanathan, S. and Lim, S.Y. and Tan, P.H. and Hübner, N. and Coffman, T. and Cook, S.
Journal of the American Society of Nephrology 33 (4): 718-730. April 2022

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E. and Kayser, C. and Maiellaro, I. and Nemec, K. and Möller, J. and Koschinski, A. and Zaccolo, M. and Annibale, P. and Falcke, M. and Lohse, M.J. and Bock, A.
Cell 185 (7): 1130-1142.e11. 31 March 2022

Phosphoinositide conversion inactivates R-RAS and drives metastases in breast cancer.
Li, H. and Prever, L. and Hsu, M.Y. and Lo, W.T. and Margaria, J.P. and De Santis, M.C. and Zanini, C. and Forni, M. and Novelli, F. and Pece, S. and Di Fiore, P.P. and Porporato, P.E. and Martini, M. and Belabed, H. and Nazare, M. and Haucke, V. and Gulluni, F. and Hirsch, E.
Advanced Science 9 (9): e2103249. 25 March 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M. and Lin, M. and Maertzdorf, J. and Heuberger, J. and Muellerke, S. and Zuo, X. and Vidal, R. and Shureiqi, I. and Fischer, A.S. and Sauer, S. and Berger, H. and Kidess, E. and Mollenkopf, H.J. and Tacke, F. and Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

Targeting cathepsin C in PR3-ANCA vasculitis.
Jerke, U. and Eulenberg-Gustavus, C. and Rousselle, A. and Nicklin, P. and Kreideweiss, S. and Grundl, M.A. and Eickholz, P. and Nickles, K. and Schreiber, A. and Korkmaz, B. and Kettritz, R.
Journal of the American Society of Nephrology 33 (5): 936-947. 15 March 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G. and Conlon, T.M. and Jeridi, A. and Kim, R. and Ertüz, Z. and Lang, N.J. and Ansari, M. and Novikova, M. and Jiang, D. and Strunz, M. and Gaianova, M. and Hollauer, C. and Gabriel, C. and Angelidis, I. and Doll, S. and Pestoni, J.C. and Edelmann, S.L. and Kohlhepp, M.S. and Guillot, A. and Bassler, K. and Van Eeckhoutte, H.P. and Kayalar, Ö. and Konyalilar, N. and Kanashova, T. and Rodius, S. and Ballester-López, C. and Genes Robles, C.M. and Smirnova, N. and Rehberg, M. and Agarwal, C. and Krikki, I. and Piavaux, B. and Verleden, S.E. and Vanaudenaerde, B. and Königshoff, M. and Dittmar, G. and Bracke, K.R. and Schultze, J.L. and Watz, H. and Eickelberg, O. and Stoeger, T. and Burgstaller, G. and Tacke, F. and Heissmeyer, V. and Rinkevich, Y. and Bayram, H. and Schiller, H.B. and Conrad, M. and Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O. and Halpert, G. and Schimke, L.F. and Ostrinski, Y. and Vojdani, A. and Baiocchi, G.C. and Freire, P.P. and Filgueiras, I.S. and Zyskind, I. and Lattin, M.T. and Tran, F. and Schreiber, S. and Marques, A.H.C. and Plaça, D.R. and Fonseca, D.L.M. and Humrich, J.Y. and Müller, A. and Giil, L.M. and Graßhoff, H. and Schumann, A. and Hackel, A. and Junker, J. and Meyer, C. and Ochs, H.D. and Lavi, Y.B. and Scheibenbogen, C. and Dechend, R. and Jurisica, I. and Schulze-Forster, K. and Silverberg, J.I. and Amital, H. and Zimmerman, J. and Heidecke, H. and Rosenberg, A.Z. and Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13 (1): 1220. 9 March 2022

Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly.
Li, H. and Janssens, J. and De Waegeneer, M. and Kolluru, S.S. and Davie, K. and Gardeux, V. and Saelens, W. and David, F.P.A. and Brbić, M. and Spanier, K. and Leskovec, J. and McLaughlin, C.N. and Xie, Q. and Jones, R.C. and Brueckner, K. and Shim, J. and Tattikota, S.G. and Schnorrer, F. and Rust, K. and Nystul, T.G. and Carvalho-Santos, Zi. and Ribeiro, C. and Pal, S. and Mahadevaraju, S. and Przytycka, T.M. and Allen, A.M. and Goodwin, S.F. and Berry, C.W. and Fuller, M.T. and White-Cooper, H. and Matunis, E.L. and DiNardo, S. and Galenza, A. and O'Brien, L.E. and Dow, J.A.T. and Jasper, H. and Oliver, B. and Perrimon, N. and Deplancke, B. and Quake, S.R. and Luo, L. and Aerts, S.
Science 375 (6584): eabk2432. 4 March 2022

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M. and von Arx, A.S. and Cruz-Ochoa, N. and Dawson, K. and Ivanov, A. and Mueller, F.S. and Lin, H.Y. and Amport, R. and Mildenberger, W. and Mattei, D. and Beule, D. and Földy, C. and Greter, M. and Notter, T. and Meyer, U.
Science Advances 8 (9): eabi6672. 4 March 2022

Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M. and Yu, H. and Yu, X. and Liang, S. and Hu, Y. and Luo, Y. and Izsvák, Z. and Sun, C. and Wang, J.
Cell Stem Cell 29 (3): 400-418.e13. 3 March 2022

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J. and Bamopoulos, S.A. and Köse, H. and Orben, F. and Zang, C. and Pons, M. and den Dekker, A.T. and Brouwer, R.W.W. and Baluapuri, A. and Habringer, S. and Reichert, M. and Illendula, A. and Krämer, O.H. and Schick, M. and Wolf, E. and van IJcken, W.F.J. and Esposito, I. and Keller, U. and Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119 (9): e2105691119. 1 March 2022

Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T. and Zhang, Y. and Vadas, O. and Roske, Y. and Gulluni, F. and De Santis, M.C. and Zagar, A.V. and Stephanowitz, H. and Hirsch, E. and Liu, F. and Daumke, O. and Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29 (3): 218-228. March 2022

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić, S. and Prada-Medina, C.A. and Landoulsi, Z. and Ghelfi, J. and Delcambre, S. and Dietrich, C. and Jarazo, J. and Henck, J. and Balachandran, S. and Pachchek, S. and Morris, C.M. and Antony, P. and Timmermann, B. and Sauer, S. and Pereira, S.L. and Schwamborn, J.C. and May, P. and Grünewald, A. and Spielmann, M.
Brain 145 (3): 964-978. March 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S. and Busch, C.J.L. and Molawi, K. and Geirsdottir, L. and Maurizio, J. and Vargas Aguilar, S. and Belahbib, H. and Gimenez, G. and Yuda, R.A.A. and Burkon, M. and Favret, J. and Gholamhosseinian Najjar, S. and de Laval, B. and Kandalla, P.K. and Sarrazin, S. and Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23 (3): 458-468. March 2022

A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.
Shahan, R. and Hsu, C.W. and Nolan, T.M. and Cole, B.J. and Taylor, I.W. and Greenstreet, L. and Zhang, S. and Afanassiev, A. and Vlot, A.H.C. and Schiebinger, G. and Benfey, P.N. and Ohler, U.
Developmental Cell 57 (4): 543-560. 28 February 2022

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.
Miller, T.E. and Lareau, C.A. and Verga, J.A. and DePasquale, E.A.K. and Liu, V. and Ssozi, D. and Sandor, K. and Yin, Y. and Ludwig, L.S. and El Farran, C.A. and Morgan, D.M. and Satpathy, A.T. and Griffin, G.K. and Lane, A.A. and Love, J.C. and Bernstein, B.E. and Sankaran, V.G. and van Galen, P.
Nature Biotechnology 40 (7): 1030-1034. 24 February 2022

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D. and Ramberger, E. and Bohl, S.R. and Dolnik, A. and Steinebach, C. and Conrad, T. and Müller, S. and Popp, O. and Kull, M. and Haji, M. and Gütschow, M. and Döhner, H. and Walther, W. and Keller, U. and Bullinger, L. and Mertins, P. and Krönke, J.
Nature Communications 13 (1): 1009. 23 February 2022

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K. and Leunig, A. and Kaiser, R. and Joppich, M. and Brambs, S. and Janjic, A. and Popp, O. and Nixdorf, D. and Fumagalli, V. and Schmidt, N. and Polewka, V. and Anjum, A. and Knottenberg, V. and Eivers, L. and Wange, L.E. and Gold, C. and Kirchner, M. and Muenchhoff, M. and Hellmuth, J.C. and Scherer, C. and Rubio-Acero, R. and Eser, T. and Deák, F. and Puchinger, K. and Kuhl, N. and Linder, A. and Saar, K. and Tomas, L. and Schulz, C. and Wieser, A. and Enard, W. and Kroidl, I. and Geldmacher, C. and von Bergwelt-Baildon, M. and Keppler, O.T. and Munschauer, M. and Iannacone, M. and Zimmer, R. and Mertins, P. and Hubner, N. and Hoelscher, M. and Massberg, S. and Stark, K. and Nicolai, L.
Nature Communications 13 (1): 1018. 23 February 2022

Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Mohammed, M. and Johnson, D.N. and Wang, L.A. and Harden, S.W. and Sheng, W. and Spector, E.A. and Elsaafien, K. and Bader, M. and Steckelings, U.M. and Scott, K.A. and Frazier, C.J. and Sumners, C. and Krause, E.G. and de Kloet, A.D.
Cardiovascular Research 118 (3): 883-896. 21 February 2022

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Reincke, S.M. and Yuan, M. and Kornau, H.C. and Corman, V.M. and van Hoof, S. and Sánchez-Sendin, E. and Ramberger, M. and Yu, W. and Hua, Y. and Tien, H. and Schmidt, M.L. and Schwarz, T. and Jeworowski, L.M. and Brandl, S.E. and Rasmussen, H.F. and Homeyer, M.A. and Stöffler, L. and Barner, M. and Kunkel, D. and Huo, S. and Horler, J. and von Wardenburg, N. and Kroidl, I. and Eser, T.M. and Wieser, A. and Geldmacher, C. and Hoelscher, M. and Gänzer, H. and Weiss, G. and Schmitz, D. and Drosten, C. and Prüss, H. and Wilson, I.A. and Kreye, J.
Science 375 (6582): 782-787. 18 February 2022

Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
Bishop, M.R. and Dickinson, M. and Purtill, D. and Barba, P. and Santoro, A. and Hamad, N. and Kato, K. and Sureda, A. and Greil, R. and Thieblemont, C. and Morschhauser, F. and Janz, M. and Flinn, I. and Rabitsch, W. and Kwong, Y.L. and Kersten, M.J and Minnema, M.C. and Holte, H. and Chan, E.H.L. and Martinez-Lopez, J. and Müller, A.M.S. and Maziarz, R.T. and McGuirk, J.P. and Bachy, E. and Le Gouill, S. and Dreyling, M. and Harigae, H. and Bond, D. and Andreadis, C. and McSweeney, P. and Kharfan-Dabaja, M. and Newsome, S. and Degtyarev, E. and Awasthi, R. and Del Corral, C. and Andreola, G. and Masood, A. and Schuster, S.J. and Jäger, U. and Borchmann, P. and Westin, J.R.
New England Journal of Medicine 386 (7): 629-639. 17 February 2022

Microbiome and metabolome features of the cardiometabolic disease spectrum.
Fromentin, S. and Forslund, S.K. and Chechi, K. and Aron-Wisnewsky, J. and Chakaroun, R. and Nielsen, T. and Tremaroli, V. and Ji, B. and Prifti, E. and Myridakis, A. and Chilloux, J. and Andrikopoulos, P. and Fan, Y. and Olanipekun, M.T. and Alves, R. and Adiouch, S. and Bar, N. and Talmor-Barkan, Y. and Belda, E. and Caesar, R. and Coelho, L.P. and Falony, G. and Fellahi, S. and Galan, P. and Galleron, N. and Helft, G. and Hoyles, L. and Isnard, R. and Le Chatelier, E. and Julienne, H. and Olsson, L. and Pedersen, H.K. and Pons, N. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Schmidt, T.S.B. and Vieira-Silva, S. and Li, P. and Zimmermann-Kogadeeva, M. and Lewinter, C. and Søndertoft, N.B. and Hansen, T.H. and Gauguier, D. and Gøtze, J.P. and Køber, L. and Kornowski, R. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Hercberg, S. and Letunic, I. and Bäckhed, F. and Oppert, J.M. and Nielsen, J. and Raes, J. and Bork, P. and Stumvoll, M. and Segal, E. and Clément, K. and Dumas, M.E. and Ehrlich, S.D. and Pedersen, O.
Nature Medicine 28 (2): 303-314. 17 February 2022

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Schnoeder, T.M. and Schwarzer, A. and Jayavelu, A.K. and Hsu, C.J. and Kirkpatrick, J. and Döhner, K. and Perner, F. and Eifert, T. and Huber, N. and Arreba-Tutusaus, P. and Dolnik, A. and Assi, S.A. and Nafria, M. and Jiang, L. and Dai, Y.T. and Chen, Z. and Chen, S.J. and Kellaway, S.G. and Ptasinska, A. and Ng, E.S. and Stanley, E.G. and Elefanty, A.G. and Buschbeck, M. and Bierhoff, H. and Brodt, S. and Matziolis, G. and Fischer, K.D. and Hochhaus, A. and Chen, C.W. and Heidenreich, O. and Mann, M. and Lane, S.W. and Bullinger, L. and Ori, A. and von Eyss, B. and Bonifer, C. and Heidel, F.
Blood 139 (7): 1080-1097. 17 February 2022

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia, A. and Zimmermann, F. and Schumann, P. and Jasina, A. and Roessler, J. and Schmidt, D. and Heinze, P. and Kaisler, J. and Nageswaran, V. and Aigner, A. and Ceglarek, U. and Cineus, R. and Hegazy, A.N. and van der Vorst, E.P.C. and Döring, Y. and Strauch, C.M. and Nemet, I. and Tremaroli, V. and Dwibedi, C. and Kränkel, N. and Leistner, D.M. and Heimesaat, M.M. and Bereswill, S. and Rauch, G. and Seeland, U. and Soehnlein, O. and Müller, D.N. and Gold, R. and Bäckhed, F. and Hazen, S.L. and Haghikia, A. and Landmesser, U.
European Heart Journal 43 (6): ehab644. 7 February 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Hillus, D. and Petrov, L. and Stein, J. and Dey, H.P. and Paclik, D. and Iwert, C. and Mülleder, M. and Aulakh, S.K. and Djudjaj, S. and Bülow, R.D. and Mei, H.E. and Schulz, A.R. and Thiel, A. and Hippenstiel, S. and Saliba, A.E. and Eils, R. and Lehmann, I. and Mall, M.A. and Stricker, S. and Röhmel, J. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer, B. and von Stillfried, S. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
Cell 185 (3): 493-512. 3 February 2022

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
Kaneshige, A. and Kaji, T. and Zhang, L. and Saito, H. and Nakamura, A. and Kurosawa, T. and Ikemoto-Uezumi, M. and Tsujikawa, K. and Seno, S. and Hori, M. and Saito, Y. and Matozaki, T. and Maehara, K. and Ohkawa, Y. and Potente, M. and Watanabe, S. and Braun, T. and Uezumi, A. and Fukada, S.I.
Cell Stem Cell 29 (2): 265-280. 3 February 2022

Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
Offer, S. and Hartner, E. and Di Bucchianico, S. and Bisig, C. and Bauer, S. and Pantzke, J. and Zimmermann, E.J. and Cao, X. and Binder, S. and Kuhn, E. and Huber, A. and Jeong, S. and Käfer, U. and Martens, P. and Mesceriakovas, A. and Bendl, J. and Brejcha, R. and Buchholz, A. and Gat, D. and Hohaus, T. and Rastak, N. and Jakobi, G. and Kalberer, M. and Kanashova, T. and Hu, Y. and Ogris, C. and Marsico, A. and Theis, F. and Pardo, M. and Gröger, T. and Oeder, S. and Orasche, J. and Paul, A. and Ziehm, T. and Zhang, Z.H. and Adam, T. and Sippula, O. and Sklorz, M. and Schnelle-Kreis, J. and Czech, H. and Kiendler-Scharr, A. and Rudich, Y. and Zimmermann, R.
Environmental Health Perspectives 130 (2): 27003. 3 February 2022

Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C. and Polovitskaya, M.M. and Delgado, B.D. and Jentsch, T.J. and Long, S.B.
Science Advances 8 (5): eabm3942. 2 February 2022

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R. and Amoroso, V. and Andziak, B. and Avdieiev, S. and Azpurua, J. and Barker, A.J. and Bennett, N.C. and Brieño-Enríquez, M.A. and Bronner, G.N. and Coen, C. and Delaney, M.A. and Dengler-Crish, C.M. and Edrey, Y.H. and Faulkes, C.G. and Frankel, D. and Friedlander, G. and Gibney, P.A. and Gorbunova, V. and Hine, C. and Holmes, M.M. and Jarvis, J.U.M. and Kawamura, Y. and Kutsukake, N. and Kenyon, C. and Khaled, W.T. and Kikusui, T. and Kissil, J. and Lagestee, S. and Larson, J. and Lauer, A. and Lavrenchenko, L.A. and Lee, A. and Levitt, J.B. and Lewin, G.R. and Lewis Hardell, K.N. and Lin, T.D. and Mason, M.J. and McCloskey, D. and McMahon, M. and Miura, K. and Mogi, K. and Narayan, V. and O'Connor, T.P. and Okanoya, K. and O'Riain, M.J. and Park, T.J. and Place, N.J. and Podshivalova, K. and Pamenter, M.E. and Pyott, S.J. and Reznick, J. and Ruby, J.G. and Salmon, A.B. and Santos-Sacchi, J. and Sarko, D.K. and Seluanov, A. and Shepard, A. and Smith, M. and Storey, K.B. and Tian, X. and Vice, E.N. and Viltard, M. and Watarai, Ak. and Wywial, E. and Yamakawa, M. and Zemlemerova, E.D. and Zions, M. and Smith, E.S.J.
Biological Reviews 97 (1): 115-140. February 2022

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W. and Akalin, A. and Ohler, U.
Nature Machine Intelligence 4 (2): 162-168. February 2022

Treatment with ribociclib shows favourable immunomodulatory effects in patients with hormone receptor-positive breast cancer-findings from the RIBECCA trial.
Peuker, C.A. and Yaghobramzi, S. and Grunert, C. and Keilholz, L and Gjerga, E. and Hennig, S. and Schaper, S. and Na, I.K. and Keller, U. and Brucker, S. and Decker, T. and Fasching, P. and Fehm, T. and Janni, W. and Kümmel, S. and Schneeweiss, A. and Schuler, M. and Lüftner, D. and Busse, A.
European Journal of Cancer 162 : 45-55. February 2022

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
Talmor-Barkan, Y. and Bar, N. and Shaul, A.A. and Shahaf, N. and Godneva, A. and Bussi, Y. and Lotan-Pompan, M. and Weinberger, A. and Shechter, A. and Chezar-Azerrad, C. and Arow, Z. and Hammer, Y. and Chechi, K. and Forslund, S.K. and Fromentin, S. and Dumas, M.E. and Ehrlich, S.D. and Pedersen, O. and Kornowski, R. and Segal, E.
Nature Medicine 28 (2): 295-302. February 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E. and Brückner, L. and Henssen, A.G.
Nature Genetics 54 (2): 107-114. February 2022

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke, A.C. and Doebele, C. and Zindel, A. and Lee, K.S. and Rieke, S.A. and Ceribelli, M. and Comoglio, F. and Phelan, J.D. and Wang, J.Q. and Pikman, Y. and Jahn, D. and Häupl, B. and Schneider, C. and Scheich, S. and Tosto, F.A. and Bohnenberger, H. and Stauder, P. and Schnütgen, F. and Slabicki, M. and Coulibaly, Z.A. and Wolf, S. and Bojarczuk, K. and Chapuy, B. and Brandts, C.H. and Stroebel, P. and Lewis, C.A. and Engelke, M. and Xu, X. and Kim, H. and Dang, T.H. and Schmitz, R. and Hodson, D.J. and Stegmaier, K. and Urlaub, H. and Serve, H. and Schmitt, C.A. and Kreuz, F. and Knittel, G. and Rabinowitz, J.D. and Reinhardt, H.C. and Vander Heiden, M.G. and Thomas, C. and Staudt, L.M. and Zenz, T. and Oellerich, T.
Blood 139 (4): 538-553. 27 January 2022

Towards the biogeography of prokaryotic genes.
Coelho, L.P. and Alves, R. and Del Río, Á.R. and Myers, P.N. and Cantalapiedra, C.P. and Giner-Lamia, J. and Schmidt, T.S. and Mende, D.R. and Orakov, A. and Letunic, I. and Hildebrand, F. and Van Rossum, T. and Forslund, S.K. and Khedkar, S. and Maistrenko, O.M. and Pan, S. and Jia, L. and Ferretti, P. and Sunagawa, S. and Zhao, X.M. and Nielsen, H.B. and Huerta-Cepas, J. and Bork, P.
Nature 601 (7892): 252-256. 13 January 2022

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Schick, M. and Zhang, L. and Maurer, S. and Maurer, H.C. and Isaakaidis, K. and Schneider, L. and Patra, U. and Schunck, K. and Rohleder, E. and Hofstetter, J. and Baluapuri, A. and Scherger, A.K. and Slotta-Huspenina, J. and Hettler, F. and Weber, J. and Engleitner, T. and Maresch, R. and Slawska, J. and Lewis, R. and Istvanffy, R. and Habringer, S. and Steiger, K. and Baiker, A. and Oostendorp, R.A.J. and Miething, C. and Lenhof, H.P. and Bassermann, F. and Chapuy, B. and Wirth, M. and Wolf, E. and Rad, R. and Müller, S. and Keller, U.
Nature Communications 13 (1): 281. 12 January 2022

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Belda, E. and Voland, L. and Tremaroli, V. and Falony, G. and Adriouch, S. and Assmann, K.E. and Prifiti, E. and Aron-Wisnewsky, J. and Debédat, J. and Le Roy, T. and Nielsen, T. and Amouyal, C. and André, S. and Andreelli, F. and Blüher, M. and Chakaroun, R. and Chilloux, J. and Coelho, L.P. and Dao, M.C. and Das, P. and Fellahi, S. and Forslund, S. and Galleron, N. and Hansen, T.H. and Holmes, B. and Ji, B. and Krogh Pedersen, H. and Le, P. and Le Chatelier, E. and Lewinter, C. and Mannerås-Holm, L. and Marquet, F. and Myridakis, A. and Pelloux, V. and Pons, N. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Sokolovska, N. and Søndertoft, N.B. and Touch, S. and Vieira-Silva, S. and Galan, P. and Holst, J. and Gøtze, J.P. and Køber, L. and Vestergaard, H. and Hansen, T. and Hercberg, S. and Oppert, J.M. and Nielsen, J. and Letunic, I. and Dumas, M.E. and Stumvoll, M. and Pedersen, O.B. and Bork, P. and Ehrlich, S.D. and Zucker, J.D. and Bäckhed, F. and Raes, J. and Clément, K.
Gut 11 January 2022 (In Press)

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R. and Aronsen, J.M. and Bergan-Dahl, A. and Moutty, M.C. and Lunde, M. and Lunde, P.K. and Jarstadmarken, H. and Wanichawan, P. and Pereira, L. and Kolstad, T.R.S. and Dalhus, B. and Subramanian, H. and Hille, S. and Christensen, G. and Müller, O.J. and Nikolaev, V. and Bers, D.M. and Sjaastad, I. and Shen, X. and Louch, W.E. and Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Hahn, T. and Ernsting, J. and Winter, N.R. and Holstein, V. and Leenings, R. and Beisemann, M. and Fisch, L. and Sarink, K. and Emden, D. and Opel, N. and Redlich, R. and Repple, J. and Grotegerd, D. and Meinert, S. and Hirsch, J.G. and Niendorf, T. and Endemann, B. and Bamberg, F. and Kröncke, T. and Bülow, R. and Völzke, H. and von Stackelberg, O. and Sowade, R.F. and Umutlu, L. and Schmidt, B. and Caspers, S. and Kugel, H. and Kircher, T. and Risse, B. and Gaser, C. and Cole, J.H. and Dannlowski, U. and Berger, K.
Science Advances 8 (1): eabg9471. 7 January 2022

Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
Heumüller, A.W. and Jones, A. N. and Mourão, A. and Klangwart, M. and Shi, C. and Wittig, I. and Fischer, A. and Muhly Reinholz, M. and Buchmann, G.K. and Dieterich, C. and Potente, M. and Braun, T. and Grote, P. and Jaé, N. and Sattler, M. and Dimmeler, S.
Circulation Research 130 (1): 67-79. 7 January 2022

A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.
Patsalos, A. and Halasz, L. and Medina-Serpas, M.A. and Berger, W.K. and Daniel, B. and Tzerpos, P. and Kiss, M. and Nagy, G. and Fischer, C. and Simandi, Z. and Varga, T. and Nagy, L.
Journal of Experimental Medicine 219 (1): e20210420. 3 January 2022

Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
Rücker, F.G. and Du, L. and Luck, T.J. and Benner, A. and Krzykalla, J. and Gathmann, I. and Voso, M.T. and Amadori, S. and Prior, T.W. and Brandwein, J.M. and Appelbaum, F.R. and Medeiros, B.C. and Tallman, M.S. and Savoie, L. and Sierra, J. and Pallaud, C. and Sanz, M.A. and Jansen, J.H. and Niederwieser, D. and Fischer, T. and Ehninger, G. and Heuser, M. and Ganser, A. and Bullinger, L. and Larson, R.A. and Bloomfield, C.D. and Stone, R.M. and Döhner, H. and Thiede, C. and Döhner, K.
Leukemia 36 (1): 90-99. January 2022

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D. and Dietrich, O. and Mari, T. and von Stillfried, S. and Ibarra, I.L. and Mittermaier, M. and Mache, C. and Chua, R.L. and Knoll, R. and Timm, S. and Brumhard, S. and Krammer, T. and Zauber, H. and Hiller, A.L. and Pascual-Reguant, A. and Mothes, R. and Bülow, R.D. and Schulze, J. and Leipold, A.M. and Djudjaj, S. and Erhard, F. and Geffers, R. and Pott, F. and Kazmierski, J. and Radke, J. and Pergantis, P. and Baßler, K. and Conrad, C. and Aschenbrenner, A.C. and Sawitzki, B. and Landthaler, M. and Wyler, E. and Horst, D. and Hippenstiel, S. and Hocke, A. and Heppner, F.L. and Uhrig, A. and Garcia, C. and Machleidt, F. and Herold, S. and Elezkurtaj, S. and Thibeault, C. and Witzenrath, M. and Cochain, C. and Suttorp, N. and Drosten, C. and Goffinet, C. and Kurth, F. and Schultze, J.L. and Radbruch, H. and Ochs, M. and Eils, R. and Müller-Redetzky, H. and Hauser, A.E. and Luecken, M.D. and Theis, F.J. and Conrad, C. and Wolff, T. and Boor, P. and Selbach, M. and Saliba, A.E. and Sander, L.E.
Cell 184 (26): 6243-6261. 22 December 2021

Extracellular matrix in heart Failure: role of ADAMTS5 in proteoglycan remodeling.
Barallobre-Barreiro, J. and Radovits, T. and Fava, M. and Mayr, U. and Lin, W.Y. and Ermolaeva, E. and Martínez-López, D. and Lindberg, E.L. and Duregotti, E. and Daróczi, L. and Hasman, M. and Schmidt, L.E. and Singh, B. and Lu, R. and Baig, F. and Siedlar, A.M. and Cuello, F. and Catibog, N. and Theofilatos, K. and Shah, A.M. and Crespo-Leiro, M.G. and Doménech, N. and Hübner, N. and Merkely, B. and Mayr, M.
Circulation 144 (25): 2021-2034. 21 December 2021

Deep tissue scattering compensation with three-photon F-SHARP.
Berlage, C. and Tantirigama, M.L.S. and Babot, M. and Di Battista, D. and Whitmire, C. and Papadopoulos, I.N. and Poulet, J.F.A. and Larkum, M. and Judkewitz, B.
Optica 8 (12): 1613-1619. 20 December 2021

Combinatorial, additive and dose-dependent drug-microbiome associations.
Forslund, S.K. and Chakaroun, R. and Zimmermann-Kogadeeva, M. and Markó, L. and Aron-Wisnewsky, J. and Nielsen, T. and Moitinho-Silva, L. and Schmidt, T.S.B. and Falony, G. and Vieira-Silva, S. and Adriouch, S. and Alves, R.J. and Assmann, K. and Bastard, J.P. and Birkner, T. and Caesar, R. and Chilloux, J. and Coelho, L.P. and Fezeu, L. and Galleron, N. and Helft, G. and Isnard, R. and Ji, B. and Kuhn, M. and Le Chatelier, E. and Myridakis, A. and Olsson, L. and Pons, N. and Prifti, E. and Quinquis, B. and Roume, H. and Salem, J.E. and Sokolovska, N. and Tremaroli, V. and Valles-Colomer, M. and Lewinter, C. and Søndertoft, N.B. and Pedersen, H.K. and Hansen, T.H. and Gøtze, J.P. and Køber, L. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Hercberg, S. and Oppert, J.M. and Letunic, I. and Nielsen, J. and Bäckhed, F. and Ehrlich, S.D. and Dumas, M.E. and Raes, J. and Pedersen, O. and Clément, K. and Stumvoll, M. and Bork, P.
Nature 600 : 500-505. 16 December 2021

CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N. and Eckstein, J. and Wallach, I. and Nordmeyer, S. and Kelm, M. and Kirchner, M. and Goubergrits, L. and Schafstedde, M. and Hennemuth, A. and Kraus, M. and Grune, T. and Mertins, P. and Kuehne, T. and Holzhütter, H.G.
Circulation 144 (24): 1926-1939. 14 December 2021

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F. and Corbo, J. and Levdansky, Y. and Spiegelhalter, A. and Lindner, D. and Magg, V. and Lebedeva, S. and Schweiggert, J. and Schott, J. and Valkov, E. and Stoecklin, G.
Nature Communications 12 (1): 7175. 9 December 2021

The SEQC2 epigenomics quality control (EpiQC) study.
Foox, J. and Nordlund, J. and Lalancette, C. and Gong, T. and Lacey, M. and Lent, S. and Langhorst, B.W. and Ponnaluri, V.K.C. and Williams, L. and Padmanabhan, K.R. and Cavalcante, R. and Lundmark, A. and Butler, D. and Mozsary, C. and Gurvitch, J. and Greally, J.M. and Suzuki, M. and Menor, M. and Nasu, M. and Alonso, A. and Sheridan, C. and Scherer, A. and Bruinsma, S. and Golda, G. and Muszynska, A. and Łabaj, P.P. and Campbell, M.A. and Wos, F. and Raine, A. and Liljedahl, U. and Axelsson, T. and Wang, C. and Chen, Z. and Yang, Z. and Li, J. and Yang, X. and Wang, H. and Melnick, A. and Guo, S. and Blume, A. and Franke, V. and Ibanez de Caceres, I. and Rodriguez-Antolin, C. and Rosas, R. and Davis, J.W. and Ishii, J. and Megherbi, D.B. and Xiao, W. and Liao, W. and Xu, J. and Hong, H. and Ning, B. and Tong, W. and Akalin, A. and Wang, Y. and Deng, Y. and Mason, C.E.
Genome Biology 22 (1): 332. 6 December 2021

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.
Glaser, L.V. and Steiger, M. and Fuchs, A. and van Bömmel, A. and Einfeldt, E. and Chung, H.R. and Vingron, M. and Meijsing, S.H.
Nucleic Acids Research 49 (21): 12178-12195. 2 December 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K. and Kny, M. and Huang, N. and Klassert, T.E. and Stock, M. and Hahn, A. and Graeger, S. and Todiras, M. and Schmidt, S. and Chamling, B. and Willenbrock, M. and Groß, S. and Biedenweg, D. and Heuser, A. and Scheidereit, C. and Butter, C. and Felix, S.B. and Otto, O. and Luft, F.C. and Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Hur, J. and Otegbeye, E. and Joh, H.K. and Nimptsch, K. and Ng, K. and Ogino, S. and Meyerhardt, J.A. and Chan, A.T. and Willett, W.C. and Wu, K. and Giovannucci, E. and Cao, Y.
Gut 70 (12): 2330-2336. December 2021

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
Kayser, S. and Schlenk, R.F. and Lebon, D. and Carre, M. and Götze, K.S. and Stölzel, F. and Berceanu, A. and Schäfer-Eckart, K. and Peterlin, P. and Hicheri, Y. and Rahme, R. and Raffoux, E. and Chermat, F. and Krause, S.W. and Aulitzky, W.E. and Rigaudeau, S. and Noppeney, R. and Berthon, C. and Görner, M. and Jost, E. and Carassou, P. and Keller, U. and Orvain, C. and Braun, T. and Saillard, C. and Arar, A. and Kunzmann, V. and Wemeau, M. and De Wit, M. and Niemann, D. and Bonmati, C. and Schwänen, C. and Abraham, J. and Aljijakli, A. and Haiat, S. and Krämer, A. and Reichle, A. and Gnadler, M. and Willekens, C. and Spiekermann, K. and Hiddemann, W. and Müller-Tidow, C. and Thiede, C. and Röllig, C. and Serve, H. and Bornhäuser, M. and Baldus, C.D. and Lengfelder, E. and Fenaux, P. and Platzbecker, U. and Adès, L.
Haematologica 106 (12): 3100-3106. December 2021

Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L. and Gohil, S.H. and Lareau, C. and Ludwig, L.S. and Parry, E.M. and Huang, T. and Li, S. and Zhang, W. and Livitz, D. and Leshchiner, I. and Parida, L. and Getz, G. and Rassenti, L.Z. and Kipps, T.J. and Brown, J.R. and Davids, M.S. and Neuberg, D.S. and Livak, K.J. and Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11 (12): 3048-3063. December 2021

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H. and Badillo-Lisakowski, V. and Britto-Borges, T. and Kubli, D.A. and Jüttner, R. and Parakkat, P. and Lopez Carballo, J. and Hüttemeister, J. and Liss, M. and Hansen, A. and Dieterich, C. and Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13 (622): eabe8952. December 2021

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Rosswog, C. and Bartenhagen, C. and Welte, A. and Kahlert, Y. and Hemstedt, N. and Lorenz, W. and Cartolano, M. and Ackermann, S. and Perner, S. and Vogel, W. and Altmüller, J. and Nürnberg, P. and Hertwig, F. and Göhring, G. and Lilienweiss, E. and Stütz, A.M. and Korbel, J.O. and Thomas, R.K. and Peifer, M. and Fischer, M.
Nature Genetics 53 (12): 1673–1685. December 2021

Compendium of 530 metagenome-assembled bacterial and archaeal genomes from the polar Arctic Ocean.
Royo-Llonch, M. and Sánchez, P. and Ruiz-González, C. and Salazar, G. and Pedrós-Alió, C. and Sebastián, M. and Labadie, K. and Paoli, L. and M. Ibarbalz, F. and Zinger, L. and Churcheward, B. and Chaffron, S. and Eveillard, D. and Karsenti, E. and Sunagawa, S. and Wincker, P. and Karp-Boss, L. and Bowler, C. and Acinas, S.G.
Nature Microbiology 6 (12): 1561-1574. December 2021

Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T. and Kedziora, S.M. and Haase, N. and Herse, F. and Alenina, N. and Müller, D.N. and Bader, M. and Schupp, M. and Dechend, R. and Golic, M. and Kräker, K.
Diabetologia 64 (12): 2829-2842. December 2021

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S. and Vonficht, D. and Jopp-Saile, L. and Raffel, S. and Lutz, R. and Leonce, D. and Antes, M. and Hernández-Malmierca, P. and Ordoñez-Rueda, D. and Ramasz, B. and Boch, T. and Jann, J.C. and Nowak, D. and Hofmann, W.K. and Müller-Tidow, C. and Hübschmann, D. and Alexandrov, T. and Benes, V. and Trumpp, A. and Paulsen, M. and Velten, L. and Haas, S.
Nature Immunology 22 (12): 1577-1589. December 2021

Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W. and Kukalev, A. and Harabula, I. and Zea-Redondo, L. and Szabó, D. and Meijer, M. and Serebreni, L. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Irastorza-Azcarate, I. and Thieme, C.J. and Sparks, T.M. and Carvalho, S. and Fiorillo, L. and Musella, F. and Irani, E. and Triglia, E.T. and Kolodziejczyk, A.A. and Abentung, A. and Apostolova, G. and Paul, E.J. and Franke, V. and Kempfer, R. and Akalin, A. and Teichmann, S.A. and Dechant, G. and Ungless, M.A. and Nicodemi, M. and Welch, L. and Castelo-Branco, G. and Pombo, A.
Nature 599 (7886): 684-691. 25 November 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K. and Toedling, J. and Huska, M. and Cwikla, M.C. and Kruetzfeldt, L.M. and Proba, J. and Ambros, P.F. and Ambros, I.M. and Boral, S. and Lodrini, M. and Chen, C.Y. and Burkert, M. and Guergen, D. and Szymansky, A. and Astrahantseff, K. and Kuenkele, A. and Haase, K. and Fischer, M. and Deubzer, H.E. and Hertwig, F. and Hundsdoerfer, P. and Henssen, A.G. and Schwarz, R.F. and Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S. and Marenholz, I. and Esparza-Gordillo, J. and Arnau-Soler, A. and Pairo-Castineira, E. and Rüschendorf, F. and Ahluwalia, T.S. and Almqvist, C. and Arnold, A. and Baurecht, H. and Bisgaard, H. and Bønnelykke, K. and Brown, S.J. and Bustamante, M. and Curtin, J.A. and Custovic, A. and Dharmage, S.C. and Esplugues, A. and Falchi, M. and Fernandez-Orth, D. and Ferreira, M.A.R. and Franke, A. and Gerdes, S. and Gieger, C. and Hakonarson, H. and Holt, P.G. and Homuth, G. and Hubner, N. and Hysi, P.G. and Jarvelin, M.R. and Karlsson, R. and Koppelman, G.H. and Lau, S. and Lutz, M. and Magnusson, P.K.E. and Marks, G.B. and Müller-Nurasyid, M. and Nöthen, M.M. and Paternoster, L. and Pennell, C.E. and Peters, A. and Rawlik, K. and Robertson, C.F. and Rodriguez, E. and Sebert, S. and Simpson, A. and Sleiman, P.M.A. and Standl, M. and Stölzl, D. and Strauch, K. and Szwajda, A. and Tenesa, A. and Thompson, P.J. and Ullemar, V. and Visconti, A. and Vonk, J.M. and Wang, C.A. and Weidinger, S. and Wielscher, M. and Sargent, C.L. and Xu, C.J. and Lee, Y.A.
Nature Communications 12 (1): 6618. 16 November 2021

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10 (1): 2151-2168. 16 November 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B. and Knoll, R. and Bonaguro, L. and ToVinh, M. and Raabe, J. and Astaburuaga-García, R. and Schulte-Schrepping, J. and Kaiser, K.M. and Rieke, G.J. and Bischoff, J. and Monin, M.B. and Hoffmeister, C. and Schlabe, S. and De Domenico, E. and Reusch, N. and Händler, K. and Reynolds, G. and Blüthgen, N. and Hack, G. and Finnemann, C. and Nischalke, H.D. and Strassburg, C.P. and Stephenson, E. and Su, Y. and Gardner, L. and Yuan, D. and Chen, D. and Goldman, J. and Rosenstiel, P. and Schmidt, S.V. and Latz, E. and Hrusovsky, K. and Ball, A.J. and Johnson, J.M. and Koenig, P.A. and Schmidt, F.I. and Haniffa, M. and Heath, J.R. and Kümmerer, B.M. and Keitel, V. and Jensen, B. and Stubbemann, P. and Kurth, F. and Sander, L.E. and Sawitzki, B. and Aschenbrenner, A.C. and Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K. and Teranishi, K. and Ambroso, M.R. and Isas, J.M. and Vazquez-Sarandeses, E. and Lee, J.Y. and Melo, A.A. and Pandey, P. and Merken, D. and Berndt, L. and Lammers, M. and Daumke, O. and Chang, K. and Haworth, I.S. and Langen, R.
Nature Communications 12 (1): 6466. 9 November 2021

Unravelling the collateral damage of antibiotics on gut bacteria.
Maier, L. and Goemans, C.V. and Wirbel, J. and Kuhn, M. and Eberl, C. and Pruteanu, M. and Müller, P. and Garcia-Santamarina, S. and Cacace, E. and Zhang, B. and Gekeler, C. and Banerjee, T. and Anderson, E.E. and Milanese, A. and Löber, U. and Forslund, S.K. and Patil, K.R. and Zimmermann, M. and Stecher, B. and Zeller, G. and Bork, P. and Typas, A.
Nature 599 : 120-124. 4 November 2021

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A. and Gärtner, A. and Cyganek, L. and Tiburcy, M. and Tuleta, I. and Wellers, L. and Folsche, L. and Hobbach, A.J. and von Frieling-Salewsky, M. and Unger, A. and Hucke, A. and Koser, F. and Kassner, A. and Sielemann, K. and Streckfuß-Bömeke, K. and Hasenfuss, G. and Goedel, A. and Laugwitz, K.L. and Moretti, A. and Gummert, J.F. and Dos Remedios, C.G. and Reinecke, H. and Knöll, R. and van Heesch, S. and Hubner, N. and Zimmermann, W.H. and Milting, H. and Linke, W.A.
Science Translational Medicine 13 (618): eabd3079. 3 November 2021

A medullary centre for lapping in mice.
Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
Nature Communications 12 : 6307. 2 November 2021

Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures.
Kreye, J. and Wright, S.K. and van Casteren, A. and Stoeffler, L. and Machule, M.L. and Reincke, S.M. and Nikolaus, M. and van Hoof, S. and Sanchez-Sendin, E. and Homeyer, M.A. and Gómez, C.C. and Kornau, H.C. and Schmitz, D. and Kaindl, A.M. and Boehm-Sturm, P. and Mueller, S. and Wilson, M.A. and Upadhya, M.A. and Dhangar, D.R. and Greenhill, S. and Woodhall, G. and Turko, P. and Vida, I. and Garner, C.C. and Wickel, J. and Geis, C. and Fukata, Y. and Fukata, M. and Prüss, H.
Journal of Experimental Medicine 218 (11): e20210012. 1 November 2021

Reporting guidelines for human microbiome research: the STORMS checklist.
Mirzayi, C. and Renson, A. and Zohra, F. and Elsafoury, S. and Geistlinger, L. and Kasselman, L.J. and Eckenrode, K. and van de Wijgert, J. and Loughman, A. and Marques, F.Z. and MacIntyre, D.A. and Arumugam, M. and Azhar, R. and Beghini, F. and Bergstrom, K. and Bhatt, A. and Bisanz, J.E. and Braun, J. and Bravo, H.C. and Buck, G.A. and Bushman, F. and Casero, D. and Clarke, G. and Collado, M.C. and Cotter, P.D. and Cryan, J.F. and Demmer, R.T. and Devkota, S. and Elinav, E. and Escobar, J.S. and Fettweis, J. and Finn, R.D. and Fodor, A.A. and Forslund, S. and Franke, A. and Furlanello, C. and Gilbert, J. and Grice, E. and Haibe-Kains, B. and Handley, S. and Herd, P. and Holmes, S. and Jacobs, J.P. and Karstens, L. and Knight, R. and Knights, D. and Koren, O. and Kwon, D.S. and Langille, M. and Lindsay, B. and McGovern, D. and McHardy, A.C. and McWeeney, S. and Mueller, N.T. and Nezi, L. and Olm, M. and Palm, N. and Pasolli, E. and Raes, J. and Redinbo, M.R. and Rühlemann, M. and Balfour Sartor, R and Schloss, P.D. and Schriml, L. and Segal, E. and Shardell, M. and Sharpton, T. and Smirnova, E. and Sokol, H. and Sonnenburg, J.L. and Srinivasan, S. and Thingholm, L.B. and Turnbaugh, P.J. and Upadhyay, V. and Walls, R.L. and Wilmes, P. and Yamada, T. and Zeller, G. and Zhang, M. and Zhao, N. and Zhao, L. and Bao, W. and Culhane, A. and Devanarayan, V. and Dopazo, J. and Fan, X. and Fischer, M. and Jones, W. and Kusko, R. and Mason, C.E. and Mercer, T.R. and Sansone, S.A. and Scherer, A. and Shi, L. and Thakkar, S. and Tong, W. and Wolfinger, R. and Hunter, C. and Segata, N. and Huttenhower, C. and Dowd, J.B. and Jones, H.E. and Waldron, L.
Nature Medicine 27 (11): 1885-1892. November 2021

Cannabidiol converts NF(κ)B into a tumor suppressor in glioblastoma with defined antioxidative properties.
Volmar, M.N.M. and Cheng, J. and Alenezi, H. and Richter, S. and Haug, A. and Hassan, Z. and Goldberg, M. and Li, Y. and Hou, M. and Herold-Mende, C. and Maire, C.L. and Lamszus, K. and Flüh, C. and Held-Feindt, J. and Gargiulo, G. and Topping, G.J. and Schilling, F. and Saur, D. and Schneider, G. and Synowitz, M. and Schick, J.A. and Kälin, R.E. and Glass, R.
Neuro-Oncology 23 (11): 1898-1910. November 2021

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M. and Franke, V. and Bruno, M. and Grishkovskaya, I. and Kasiliauskaite, A. and Kaufmann, T. and Schoeberl, U.E. and Puchinger, M.G. and Kostrhon, S. and Ebenwaldner, C. and Sebesta, M. and Beltzung, E. and Mechtler, K. and Lin, G. and Vlasova, A. and Leeb, M. and Pavri, R. and Stark, A. and Akalin, A. and Stefl, R. and Bernecky, C. and Djinovic-Carugo, K. and Slade, D.
Nature Communications 12 (1): 6078. 19 October 2021

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O. and Nehls, N. and Prexler, C. and von Heyking, K. and Groll, T. and Pardon, K. and Garcia, H.D. and Hensel, T. and Gürgen, D. and Henssen, A.G. and Eggert, A. and Steiger, K. and Burdach, S. and Richter, G.H.S.
Journal of Experimental & Clinical Cancer Research 40 (1): 322. 15 October 2021

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S. and Koch, K. and Schriever, C. and Xu, J. and Steinecker, M. and Leber, J. and Dworatzek, E. and Purfürst, B. and Kunz, S. and Recchia, D. and Canepari, M. and Heuser, A. and Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12 : 1249-1265. 14 October 2021

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Brial, F. and Chilloux, J. and Nielsen, T. and Vieira-Silva, S. and Falony, G. and Andrikopoulos, P. and Olanipekun, M. and Hoyles, L. and Djouadi, F. and Neves, A.L. and Rodriguez-Martinez, A. and Mouawad, G.I. and Pons, N. and Forslund, S. and Le-Chatelier, E. and Le Lay, A. and Nicholson, J. and Hansen, T. and Hyötyläinen, T. and Clément, K. and Oresic, M. and Bork, P. and Ehrlich, S.D. and Raes, J. and Pedersen, O.B. and Gauguier, D. and Dumas, M.E.
Gut 70 (11): 2105-2114. 7 October 2021

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. and Bischoff, P. and Peidli, S. and Sieber, A. and Trinks, A. and Lüthen, M. and Obermayer, B. and Blanc, E. and Ruchiy, Y. and Sell, T. and Mamlouk, S. and Arsie, R. and Wei, T.T. and Klotz-Noack, K. and Schwarz, R.F. and Sawitzki, B. and Kamphues, C. and Beule, D. and Landthaler, M. and Sers, C. and Horst, D. and Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13 (10): e14123. 7 October 2021

Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
Gebert, J. and Gelincik, O. and Oezcan-Wahlbrink, M. and Marshall, J.D. and Hernandez-Sanchez, A. and Urban, K. and Long, M. and Cortes, E. and Tosti, E. and Katzenmaier, E.M. and Song, Y. and Elsaadi, A. and Deng, N. and Vilar, E. and Fuchs, V. and Nelius, N. and Yuan, Y.P. and Ahadova, A. and Sei, S. and Shoemaker, R.H. and Umar, A. and Wei, L. and Liu, S. and Bork, P. and Edelmann, W. and von Knebel Doeberitz, M. and Lipkin, S.M. and Kloor, M.
Gastroenterology 161 (4): 288-1302.e13. October 2021

Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta, S. and Short, S.A.P. and Sise, M.E. and Prosek, J.M. and Madhavan, S.M. and Soler, M.J. and Ostermann, M. and Herrmann, S.M. and Abudayyeh, A. and Anand, S. and Glezerman, I. and Motwani, S.S. and Murakami, N. and Wanchoo, R. and Ortiz-Melo, D.I. and Rashidi, A. and Sprangers, B. and Aggarwal, V. and Malik, A.B. and Loew, S. and Carlos, C.A. and Chang, W.T. and Beckerman, P. and Mithani, Z. and Shah, C.V. and Renaghan, A.D. and Seigneux, S.D. and Campedel, L. and Kitchlu, A. and Shin, D.S. and Rangarajan, S. and Deshpande, P. and Coppock, G. and Eijgelsheim, M. and Seethapathy, H. and Lee, M.D. and Strohbehn, I.A. and Owen, D.H. and Husain, M. and Garcia-Carro, C. and Bermejo, S. and Lumlertgul, N. and Seylanova, N. and Flanders, L. and Isik, B. and Mamlouk, O. and Lin, J.S. and Garcia, P. and Kaghazchi, A. and Khanin, Y. and Kansal, S.K. and Wauters, E. and Chandra, S. and Schmidt-Ott, K.M. and Hsu, R.K. and Tio, M.C. and Sarvode Mothi, S. and Singh, H. and Schrag, D. and Jhaveri, K.D. and Reynolds, K.L. and Cortazar, F.B. and Leaf, D.E.
Journal for ImmunoTherapy of Cancer 9 (10): e003467. October 2021

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K. and Kaljunen, H. and Taavitsainen, S. and Kaarijärvi, R. and Järvelä, E. and Rodriguez Martin, B. and Haase, K. and Woodcock, D.J. and Tubio, J. and Wedge, D.C. and Nykter, M. and Bova, G.S.
Cancer Research 81 (19): 4901-4909. October 2021

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.
Lewis, R. and Maurer, H.C. and Singh, N. and Gonzalez-Menendez, I. and Wirth, M. and Schick, M. and Zhang, L. and Isaakidis, K. and Scherger, A.K. and Schulze, V. and Lu, J. and Zenz, T. and Steiger, K. and Rad, R. and Quintanilla-Martinez, L. and Espeli, M. and Balabanian, K. and Keller, U. and Habringer, S.
Leukemia 35 : 2895-2905. October 2021

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
Mimitou, E.P. and Lareau, C.A. and Chen, K.Y. and Zorzetto-Fernandes, A.L. and Hao, Y. and Takeshima, Y. and Luo, W. and Huang, T.S. and Yeung, B.Z. and Papalexi, E. and Thakore, P.I. and Kibayashi, T. and Wing, J.B. and Hata, M. and Satija, R. and Nazor, K.L. and Sakaguchi, S. and Ludwig, L.S. and Sankaran, V.G. and Regev, A. and Smibert, P.
Nature Biotechnology 39 (10): 1246-1258. October 2021

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.
Moreno-Layseca, P. and Jäntti, N.Z. and Godbole, R. and Sommer, C. and Jacquemet, G. and Al-Akhrass, H. and Conway, J.R.W. and Kronqvist, P. and Kallionpää, R.E. and Oliveira-Ferrer, L. and Cervero, P. and Linder, S. and Aepfelbacher, M. and Zauber, H. and Rae, J. and Parton, R.G. and Disanza, A. and Scita, G. and Mayor, S. and Selbach, M. and Veltel, S. and Ivaska, J.
Nature Cell Biology 23 (10): 1073-1084. October 2021

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner, J. and Suwalski, P. and Holtgrewe, M. and Rakitko, A. and Thibeault, C. and Müller, M. and Patriki, D. and Quedenau, C. and Krüger, U. and Ilinsky, V. and Popov, I. and Balnis, J. and Jaitovich, A. and Helbig, E.T. and Lippert, L.J. and Stubbemann, P. and Real, L.M. and Macías, J. and Pineda, J.A. and Fernandez-Fuertes, M. and Wang, X. and Karadeniz, Z. and Saccomanno, J. and Doehn, J.M. and Hübner, R.H. and Hinzmann, B. and Salvo, M. and Blueher, A. and Siemann, S. and Jurisic, S. and Beer, J.H. and Rutishauser, J. and Wiggli, B. and Schmid, H. and Danninger, K. and Binder, R. and Corman, V.M. and Mühlemann, B. and Arjun Arkal, R. and Fragiadakis, G.K. and Mick, E. and Calfee, C.S. and Erle, D.J. and Hendrickson, C.M. and Kangelaris, K.N. and Krummel, M.F. and Woodruff, P.G. and Langelier, C.R. and Venkataramani, U. and García, F. and Zyla, J. and Drosten, C. and Braun, A. and Jones, T.C. and Suttorp, N. and Witzenrath, M. and Hippenstiel, S. and Zemojtel, T. and Skurk, C. and Wolfgang, P. and Borodina, T. and Ripke, S. and Sander, L.E. and Beule, D. and Landmesser, U. and Guettouche, T. and Kurth, F. and Heidecker, B.
EClinicalMedicine 40 : 101099. October 2021

Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response.
Mendonsa, S. and von Kuegelgen, N. and Bujanic, L. and Chekulaeva, M.
Nucleic Acids Research 49 (17): 10007-10017. 27 September 2021

Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham, R. and Litchfield, K. and Watkins, T.B.K. and Lim, E.L. and Rosenthal, R. and Martínez-Ruiz, C. and Hiley, C.T. and Bakir, M.A. and Salgado, R. and Moore, D.A. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature 597 (7877): 555-560. 23 September 2021

Bioaccumulation of therapeutic drugs by human gut bacteria.
Klünemann, M. and Andrejev, S. and Blasche, S. and Mateus, A. and Phapale, P. and Devendran, S. and Vappiani, J. and Simon, B. and Scott, T.A. and Kafkia, E. and Konstantinidis, D. and Zirngibl, K. and Mastrorilli, E. and Banzhaf, M. and Mackmull, M.T. and Hövelmann, F. and Nesme, L. and Brochado, A.R. and Maier, L. and Bock, T. and Periwal, V. and Kumar, M. and Kim, Y. and Tramontano, M. and Schultz, C. and Beck, M. and Hennig, J. and Zimmermann, M. and Sévin, D.C. and Cabreiro, F. and Savitski, M.M. and Bork, P. and Typas, A. and Patil, K.R.
Nature 597 : 533-538. 23 September 2021

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Liang, H.C. and Costanza, M. and Prutsch, N. and Zimmerman, M.W. and Gurnhofer, E. and Montes-Mojarro, I.A. and Abraham, B.J. and Prokoph, N. and Stoiber, S. and Tangermann, S. and Lobello, C. and Oppelt, J. and Anagnostopoulos, I. and Hielscher, T. and Pervez, S. and Klapper, W. and Zammarchi, F. and Silva, D.A. and Garcia, K.C. and Baker, D. and Janz, M. and Schleussner, N. and Fend, F. and Pospíšilová, Š. and Janiková, A. and Wallwitz, J. and Stoiber, D. and Simonitsch-Klupp, I. and Cerroni, L. and Pileri, S. and de Leval, L. and Sibon, D. and Fataccioli, V. and Gaulard, P. and Assaf, C. and Knörr, F. and Damm-Welk, C. and Woessmann, W. and Turner, S.D. and Look, A.T. and Mathas, S. and Kenner, L. and Merkel, O.
Nature Communications 12 (1): 5577. 22 September 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann, J. and Lorenz, C. and Borchmann, S. and Nishii, K. and Wegner, J. and Meder, L. and Ostendorp, J. and Ast, D.F. and Heimsoeth, A. and Nakasuka, T. and Hirabae, A. and Okawa, S. and Dammert, M.A. and Plenker, D. and Klein, S. and Lohneis, P. and Gu, J. and Godfrey, L.K. and Forster, J. and Trajkovic-Arsic, M. and Zillinger, T. and Haarmann, M. and Quaas, A. and Lennartz, S. and Schmiel, M. and D'Rozario, J. and Thomas, E.S. and Li, H. and Schmitt, C.A. and George, J. and Thomas, R.K. and von Karstedt, S. and Hartmann, G. and Büttner, R. and Ullrich, R.T. and Siveke, J.T. and Ohashi, K. and Schlee, M. and Sos, M.L.
Nature Communications 12 (1): 5505. 17 September 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Bloehdorn, J. and Braun, A. and Taylor-Weiner, A. and Jebaraj, B.M.C. and Robrecht, S. and Krzykalla, J. and Pan, H. and Giza, A. and Akylzhanova, G. and Holzmann, K. and Scheffold, A. and Johnston, H.E. and Yeh, R.F. and Klymenko, T. and Tausch, E. and Eichhorst, B. and Bullinger, L. and Fischer, K. and Weisser, M. and Robak, T. and Schneider, C. and Gribben, J. and Dahal, L.N. and Carter, M.J. and Elemento, O. and Landau, D.A. and Neuberg, D.S. and Cragg, M.S. and Benner, A. and Hallek, M. and Wu, C.J. and Döhner, H. and Stilgenbauer, S. and Mertens, D.
Nature Communications 12 (1): 5395. 13 September 2021

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
Franke, M. and De la Calle-Mustienes, E. and Neto, A. and Almuedo-Castillo, M. and Irastorza-Azcarate, I. and Acemel, R.D. and Tena, J.J. and Santos-Pereira, J.M. and Gómez-Skarmeta, J.L.
Nature Communications 12 (1): 5415. 13 September 2021

Locus specific epigenetic modalities of random allelic expression imbalance.
Marion-Poll, L. and Forêt, B. and Zielinski, D. and Massip, F. and Attia, M. and Carter, A.C. and Syx, L. and Chang, H.Y. and Gendrel, A.V. and Heard, E.
Nature Communications 12 (1): 5330. 9 September 2021

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva, E. and Stadiotti, I. and Casella, M. and Catto, V. and Dello Russo, A. and Carbucicchio, C. and Arnaboldi, L. and De Metrio, S. and Milano, G. and Scopece, A. and Casaburo, M. and Andreini, D. and Mushtaq, S. and Conte, E. and Chiesa, M. and Birchmeier, W. and Cogliati, E. and Paolin, A. and König, E. and Meraviglia, V. and De Musso, M. and Volani, C. and Cattelan, G. and Rauhe, W. and Turnu, L. and Porro, B. and Pedrazzini, M. and Camera, M. and Corsini, A. and Tondo, C. and Rossini, A. and Pompilio, G.
EMBO Molecular Medicine 13 (9): e14365. 7 September 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D. and Benary, U. and Margineanu, A. and Vignola, M.L. and Konrath, F. and Pongrac, I.M. and Karimaddini, Z. and Vigilante, A. and Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener, J. and Baggiolini, A. and Pernebrink, M. and Dalcher, D. and Lerra, L. and Cheng, P.F. and Varum, S. and Häusel, J. and Stierli, S. and Treier, M. and Studer, L. and Basler, K. and Levesque, M.P. and Dummer, R. and Santoro, R. and Cantù, C. and Sommer, L.
Nature Communications 12 (1): 5056. 20 August 2021

A simple pressure-assisted method for MicroED specimen preparation.
Zhao, J. and Xu, H. and Lebrette, H. and Carroni, M. and Taberman, H. and Högbom, M. and Zou, X.
Nature Communications 12 (1): 5036. 19 August 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Muelleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
Breitkreuz-Korff, O. and Tscheik, C. and Del Vecchio, G. and Dithmer, S. and Walther, W. and Orthmann, A. and Wolburg, H. and Haseloff, R.F. and Schröder, L. and Blasig, I.E. and Winkler, L.
Journal of Controlled Release 330 : 137-148. 10 August 2021

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X. and Bender, F. and Soh, H. and Chen, C. and Altafi, M. and Schütze, S. and Heidenreich, M. and Gorbati, M. and Corbu, M.A. and Carus-Cadavieco, M. and Korotkova, T. and Tzingounis, A.V. and Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12 (1): 4801. 10 August 2021

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Duncan, A.R. and Polovitskaya, M.M. and Gaitán-Peñas, H. and Bertelli, S. and VanNoy, G.E. and Grant, P.E. and O'Donnell-Luria, A. and Valivullah, Z. and Lovgren, A.K. and England, E.M. and Agolini, E. and Madden, J.A. and Schmitz-Abe, K. and Kritzer, A. and Hawley, P. and Novelli, A. and Alfieri, P. and Colafati, G.S. and Wieczorek, D. and Platzer, K. and Luppe, J. and Koch-Hogrebe, M. and Abou Jamra, R. and Neira-Fresneda, J. and Lehman, A. and Boerkoel, C.F. and Seath, K. and Clarke, L. and van Ierland, Y. and Argilli, E. and Sherr, E.H. and Maiorana, A. and Diel, T. and Hempel, M. and Bierhals, T. and Estévez, R. and Jentsch, T.J. and Pusch, M. and Agrawal, P.B.
American Journal of Human Genetics 108 (8): 1450-1465. 5 August 2021

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Young, K. and Eudy, E. and Bell, R. and Loberg, M.A. and Stearns, T. and Sharma, D. and Velten, L. and Haas, S. and Filippi, M.D. and Trowbridge, J.J.
Cell Stem Cell 28 (8): 1473-1482. 5 August 2021

NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport.
Moriel, N. and Senel, E. and Friedman, N. and Rajewsky, N. and Karaiskos, N. and Nitzan, M.
Nature Protocols 16 (9): 4177-4200. 4 August 2021

Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
Carley, L.N. and Mojica, J.P. and Wang, B. and Chen, C.Y. and Lin, Y.P. and Prasad, K.V.S.K and Chan, E. and Hsu, C.W. and Keith, R. and Nuñez, C.L. and Olson-Manning, C.F. and Rushworth, C.A. and Wagner, M.R. and Wang, J. and Yeh, P.M. and Reichelt, M. and Ghattas, K. and Gershenzon, J. and Lee, C.R. and Mitchell-Olds, T.
Nature Ecology & Evolution 5 : 1135–1144. August 2021

High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
Çınar, Ö. and Brzezicha, B. and Grunert, C. and Kloetzel, P.M. and Beier, C. and Peuker, C.A. and Keller, U. and Pezzutto, A. and Busse, A.
Journal for ImmunoTherapy of Cancer 9 (7): e002410. 30 July 2021

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P. and Song, T. and Yao, Y. and Fehlner-Peach, H. and Diamond, B. and Gu, H. and Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118 (30): e2100576118. 27 July 2021

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M. and Vancraenenbroeck, R. and Rosenblum, G. and Hofmann, H. and Mikhailov, A.S. and Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2101144118. 13 July 2021

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S. and Bartolomaeus, H. and Neubert, P. and Willebrand, R. and Zasada, C. and Bartolomaeus, T. and McParland, V. and Swinnen, D. and Geuzens, A. and Maifeld, A. and Krampert, L. and Vogl, M. and Mähler, A. and Wilck, N. and Marko, L. and Tilic, E. and Forslund, S.K. and Binger, K.J. and Stegbauer, J. and Dechend, R. and Kleinewietfeld, M. and Jantsch, J. and Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Huhn, K. and Linz, P. and Pemsel, F. and Michalke, B. and Seyferth, S. and Kopp, C. and Chaudri, M.A. and Rothhammer, V. and Dörfler, A. and Uder, M. and Nagel, A.M. and Müller, D.N. and Waschbisch, A. and Lee, D.H. and Bäuerle, T. and Linker, R.A. and Haase, S.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2102549118. 13 July 2021

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.
Liu, J. and Tassinari, M. and Souza, D.P. and Naskar, S. and Noel, J.K. and Bohuszewicz, O. and Buck, M. and Williams, T.A. and Baum, B. and Low, H.H.
Cell 184 (14): 3660-3673. 8 July 2021

CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
Huang, H. and Zhu, Q. and Jussila, A. and Han, Y. and Bintu, B. and Kern, C. and Conte, M. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Yu, M. and Hu, R. and Tastemel, M. and Juric, I. and Hu, M. and Nicodemi, M. and Zhuang, X. and Ren, B.
Nature Genetics 53 (7): 1064-1074. July 2021

Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp.
Joh, H.K. and Lee, D.H. and Hur, J. and Nimptsch, K. and Chang, Y. and Joung, H. and Zhang, X. and Rezende, L.F.M. and Lee, J.E. and Ng, K. and Chen, Y. and Tabung, F.K. and Meyerhardt, J.A. and Chan, A.T. and Pischon, T. and Song, M. and Fuchs, C.S. and Willett, W.C. and Cao, Y. and Ogino, S. and Giovannucci, E. and Wu, K.
Gastroenterology 161 (1): 128-142. July 2021

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Witte, F. and Ruiz-Orera, J. and Ciolli Mattioli, C. and Blachut, S. and Adami, E. and Schulz, J.F. and Schneider-Lunitz, V. and Hummel, O. and Patone, G. and Mücke, M.B. and Šilhavý, Jan and Heinig, M. and Bottolo, L. and Sanchis, D. and Vingron, M. and Chekulaeva, M. and Pravenec, M. and Hubner, N. and van Heesch, S.
Genome Biology 22 (1): 191. 28 June 2021

Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J. and Luxán, G. and Abplanalp, W.T. and Glaser, S.F. and Rasper, T. and Fischer, A. and Muhly-Reinholz, M. and Potente, M. and Assmus, B. and John, D. and Zeiher, A.M. and Dimmeler, S.
Nature Communications 12 (1): 3964. 25 June 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C. and Papies, J. and Bajaj, T. and Emanuel, J. and Dethloff, F. and Chua, R.L. and Trimpert, J. and Heinemann, N. and Niemeyer, C. and Weege, F. and Hönzke, K. and Aschman, T. and Heinz, D.E. and Weckmann, K. and Ebert, T. and Zellner, A. and Lennarz, M. and Wyler, E. and Schroeder, S. and Richter, A. and Niemeyer, D. and Hoffmann, K. and Meyer, T.F. and Heppner, F.L. and Corman, V.M. and Landthaler, M. and Hocke, A.C. and Morkel, M. and Osterrieder, N. and Conrad, C. and Eils, R. and Radbruch, H. and Giavalisco, P. and Drosten, C. and Müller, M.A.
Nature Communications 12 (1): 3818. 21 June 2021

Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F. and Gossmann, T.I. and Frioux, C. and Özkurt, E. and Myers, P.N. and Ferretti, P. and Kuhn, M. and Bahram, M. and Nielsen, H.B. and Bork, P.
Cell Host & Microbe 29 (7): 1167-1176. 14 June 2021

GUNC: detection of chimerism and contamination in prokaryotic genomes.
Orakov, A. and Fullam, A. and Coelho, L.P. and Khedkar, S. and Szklarczyk, D. and Mende, D.R. and Schmidt, T.S.B. and Bork, P.
Genome Biology 22 (1): 178. 13 June 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C. and Schallenberg, S. and Kirchner, M. and Ziehm, M. and Niquet, S. and Haji, M. and Beier, C. and Neudecker, J. and Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren, A.A. and Snellings, D.A. and Su, Y.S. and Hong, C.C. and Castro, M. and Tang, A.T. and Detter, M.R. and Hobson, N. and Girard, R. and Romanos, S. and Lightle, R. and Moore, T. and Shenkar, R. and Benavides, C. and Beaman, M.M. and Mueller-Fielitz, H. and Chen, M. and Mericko, P. and Yang, J. and Sung, D.C. and Lawton, M.T. and Ruppert, M. and Schwaninger, M. and Körbelin, J. and Potente, M. and Awad, I.A. and Marchuk, D.A. and Kahn, M.L.
Nature 594 (7862): :271-276. 10 June 2021

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S. and Schultze, H. and Shastry, K.L. and Manamohan, S. and Mukherjee, S. and Garg, V. and Sarveswara, R. and Händler, K. and Pickkers, P. and Aziz, N.A. and Ktena, S. and Tran, F. and Bitzer, M. and Ossowski, S. and Casadei, N. and Herr, C. and Petersheim, D. and Behrends, U. and Kern, F. and Fehlmann, T. and Schommers, P. and Lehmann, C. and Augustin, M. and Rybniker, J. and Altmüller, J. and Mishra, N. and Bernardes, J.P. and Krämer, B. and Bonaguro, L. and Schulte-Schrepping, J. and De Domenico, E. and Siever, C. and Kraut, M. and Desai, M. and Monnet, B. and Saridaki, M. and Siegel, C.M. and Drews, A. and Nuesch-Germano, M. and Theis, H. and Heyckendorf, J. and Schreiber, S. and Kim-Hellmuth, S. and Nattermann, J. and Skowasch, D. and Kurth, I. and Keller, A. and Bals, R. and Nürnberg, P. and Rieß, O. and Rosenstiel, P. and Netea, M.G. and Theis, F. and Mukherjee, S. and Backes, M. and Aschenbrenner, A.C. and Ulas, T. and Breteler, M.M.B. and Giamarellos-Bourboulis, E.J. and Kox, M. and Becker, M. and Cheran, S. and Woodacre, M.S. and Goh, E.L. and Schultze, J.L.
Nature 594 (7862): 265-270. 10 June 2021

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M. and Gmach, P. and Boltz, H.H. and Einsiedel, J. and Gotthardt, M. and Hübner, H. and Gmeiner, P. and Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
Cuello, F. and Knaust, A.E. and Saleem, U. and Loos, M. and Raabe, J. and Mosqueira, D. and Laufer, S. and Schweizer, M. and Kraak, P. and Flenner, F. and Ulmer, B.M and Braren, I. and Yin, X. and Theofilatos, K. and Ruiz-Orera, J. and Patone, G. and Klampe, B. and Schulze, T. and Piasecki, A. and Pinto, Y. and Vink, A. and Hübner, N. and Harding, S. and Mayr, M. and Denning, C. and Eschenhagen, T. and Hansen, A.
EMBO Molecular Medicine 13 (6): e13074. 7 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
Schmalbrock, L.K. and Dolnik, A. and Cocciardi, S. and Sträng, E. and Theis, F. and Jahn, N. and Panina, E. and Blätte, T.J. and Herzig, J.K. and Skambraks, S. and Rücker, F.G. and Gaidzik, V.I. and Paschka, P. and Fiedler, W. and Salih, H.R. and Wulf, G.G. and Schroeder, T. and Lübbert, M. and Schlenk, R.F. and Thol, F. and Heuser, M. and Larson, R.A. and Ganser, A. and Stunnenberg, H.G. and Minucci, S. and Stone, R.M. and Bloomfield, C.D. and Döhner, H. and Döhner, K. and Bullinger, L.
Blood 137 (22): 3093-3104. 3 June 2021

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M. and Saraswat, M. and Bessière, C. and Menichelli, C. and Ramilowski, J.A. and Severin, J. and Hayashizaki, Y. and Itoh, M. and Tagami, M. and Murata, M. and Kojima-Ishiyama, M. and Noma, S. and Noguchi, S. and Kasukawa, T. and Hasegawa, A. and Suzuki, H. and Nishiyori-Sueki, H. and Frith, M.C. and Chatelain, C. and Carninci, P. and de Hoon, M.J.L. and Wasserman, W.W. and Bréhélin, L. and Lecellier, C.H.
Nature Communications 12 (1): 3297. 2 June 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort.
Birukov, A. and Andersen, L.B. and Andersen, M.S. and Nielsen, J.H. and Nielsen, F.g and Kyhl, H.B. and Jørgensen, J.S. and Grandjean, P. and Dechend, R. and Jensen, T.K.
Environment International 151 : 106442. June 2021

Sodium and its manifold impact on our immune system.
Jobin, K. and Müller, D.N. and Jantsch, J. and Kurts, C.
Trends in Immunology 42 (6): 469-479. June 2021

PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial.
Kreissl, S. and Goergen, H. and Buehnen, I. and Kobe, C. and Moccia, A. and Greil, R. and Eichenauer, D.A. and Zijlstra, J.M. and Markova, J. and Meissner, J. and Feuring-Buske, M. and Soekler, M. and Beck, H.J. and Willenbacher, W. and Ludwig, W.D. and Pabst, T. and Topp, M.S. and Hitz, F. and Bentz, M. and Keller, U.B. and Kühnhardt, D. and Ostermann, H. and Hertenstein, B. and Aulitzky, W. and Maschmeyer, G. and Vieler, T. and Eich, H. and Baues, C. and Stein, H. and Fuchs, M. and Diehl, V. and Dietlein, M. and Engert, A. and Borchmann, P.
Lancet Haematology 8 (6): e398-e409. June 2021

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A. and Roske, Y. and Yamada, S. and Uehata, T. and Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49 (9): 5369-5381. 21 May 2021

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M. and Schrezenmeier, J.F. and Richter-Pechanska, P. and Dolnik, A. and Hick, T.P. and Schleich, K. and Cai, X. and Fan, D.N.Y. and Lohneis, P. and Masswig, S. and Denker, S. and Busse, A. and Knittel, G. and Flümann, R. and Childs, D. and Childs, L. and Gätjens-Sanchez, A.M. and Bullinger, L. and Rosenwald, A. and Reinhardt, H.C. and Schmitt, C.A.
Blood 137 (20): 2785-2899. 20 May 2021

Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin.
Mahn, M. and Saraf-Sinik, I. and Patil, P. and Pulin, M. and Bitton, E. and Karalis, N. and Bruentgens, F. and Palgi, S. and Gat, A. and Dine, J. and Wietek, J. and Davidi, I. and Levy, R. and Litvin, A. and Zhou, F. and Sauter, K. and Soba, P. and Schmitz, D. and Lüthi, A. and Rost, B.R. and Wiegert, J.S. and Yizhar, O.
Neuron 109 (10): 1621-1635. 19 May 2021

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. and Subramaniam, S. and Chomsky-Hecht, O. and Tsemakhovich, V. and Flockerzi, V. and Klussmann, E. and Hirsch, J.A. and Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I. and Holler, K. and Appelbaum, L. and Eisenberg, E. and Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49 (8): 4325-4337. 7 May 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Wilkins, K. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49 (9): 5336-5350. May 2021

Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin.
Fiorillo, L. and Musella, F. and Conte, M. and Kempfer, R. and Chiariello, A.M. and Bianco, S. and Kukalev, A. and Irastorza-Azcarate, I. and Esposito, A. and Abraham, A. and Prisco, A. and Pombo, A. and Nicodemi, M.
Nature Methods 18 (5): 482-490. May 2021

Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K. and Fogo, M.S. and Pinto, B.G.G. and Alves, A.Y. and Suzuki, A.M. and Morales, A.G. and Ezquina, S. and Sosa, O.J. and Sutton, G.J. and Sunaga-Franze, D.Y. and Bueno, A.P. and Seabra, G. and Sardinha, L. and Costa, S.S. and Rosenberg, C. and Zachi, E.C. and Sertie, A.L. and Martins-de-Souza, D. and Reis, E.M. and Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26 (5): 1589-1605. May 2021

Assessing dysferlinopathy patients over three years with a new motor scale.
Jacobs, M. and James, M.K. and Lowes, L.P. and Alfano, L.N. and Eagle, M. and Lofra, R.M. and Moore, U. and Feng, J. and Rufibach, L.E. and Rose, K. and Duong, T. and Bello, L. and Pedrosa-Hernández, I. and Holsten, S. and Sakamoto, C. and Canal, A. and Práxedes, N.S.A. and Thiele, S. and Siener, C. and Vandevelde, B. and DeWolf, B. and Maron, E. and Guglieri, M. and Hogrel, J.Y. and Blamire, A.M. and Carlier, P.G. and Spuler, S. and Day, J.W. and Jones, K.J. and Bharucha-Goebel, D.X. and Salort-Campana, E. and Pestronk, A. and Walter, M.C. and Paradas, C. and Stojkovic, T. and Mori-Yoshimura, M. and Bravver, E. and Díaz-Manera, J. and Pegoraro, E. and Mendell, J.R. and Mayhew, A.G. and Straub, V.
Annals of Neurology 89 (5): 967-978. May 2021

Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E. and Schewe, J. and Zhang, J. and Dinh, H.A. and Forslund, S.K. and Markó, L. and Hellmig, N. and Peters, J. and Muller, D.N. and Lifton, R.P. and Nottoli, T. and Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118 (17): e2014876118. 27 April 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J. and Shi, C. and Costa, A.S.H. and Choi, J. and Kim, J. and Doddaballapur, A. and Sugino, T. and Ong, Y.T. and Castro, M. and Zimmermann, B. and Kaulich, M. and Guenther, S. and Wilhelm, K. and Kubota, Y. and Braun, T. and Koh, G.Y. and Grosso, A.R. and Frezza, C. and Potente, M.
Nature Cell Biology 23 : 413-423. April 2021

SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C. and Günther, U. and Eddison, M. and Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18 : 374-377. April 2021

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K. and Hablesreiter, R. and Inoue, Y. and Yoshida, K. and Briest, F. and Christen, F. and Kakiuchi, N. and Yoshizato, T. and Shiozawa, Y. and Shiraishi, Y. and Striefler, J.K. and Bischoff, S. and Lohneis, P. and Putter, H. and Blau, O. and Keilholz, U. and Bullinger, L. and Pelzer, U. and Hummel, M. and Riess, H. and Ogawa, S. and Sinn, M. and Damm, F.
EBioMedicine 66 : 103327. April 2021

Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens, B. and Schulze, A. and Wysocki, J. and Lin, M.H. and Ye, M. and Kanwar, Y.S. and Bader, M. and Velez, J.C.Q. and Miner, J.H. and Batlle, D.
Kidney International 99 (4): 900-913. April 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 81 (8): 2116-2127. April 2021

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Chen, C.Y. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.
Wirbel, J. and Zych, K. and Essex, M. and Karcher, N. and Kartal, E. and Salazar, G. and Bork, P. and Sunagawa, S. and Zeller, G.
Genome Biology 22 (1): 93. 30 March 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J. and Kownatzki-Danger, D. and Weninger, G. and Seibertz, F. and Pronto, J.R. and Sutanto, H. and Pacheu Grau, D. and Hindmarsh, R. and Brandenburg, S. and Kohl, T. and Hasenfuβ, G. and Gotthardt, M. and Rog-Zielinska, E.A. and Wollnik, B. and Rehling, P. and Urlaub, H. and Wegener, J.W. and Heijman, J. and Voigt, N. and Cyganek, L. and Lenz, C. and Lehnart, S.E.
Circulation Research 128 (6): e102-e120. 19 March 2021

Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge.
Sieberts, S.K. and Schaff, J. and Duda, M. and Pataki, B.Á. and Sun, M. and Snyder, P. and Daneault, J.F. and Parisi, F. and Costante, G. and Rubin, U. and Banda, P. and Chae, Y. and Chaibub Neto, E. and Dorsey, E.R. and Aydın, Z. and Chen, A. and Elo, L.L. and Espino, C. and Glaab, E. and Goan, E. and Golabchi, F.N. and Görmez, Y. and Jaakkola, M.K. and Jonnagaddala, J. and Klén, R. and Li, D. and McDaniel, C. and Perrin, D. and Perumal, T.M. and Rad, N.M. and Rainaldi, E. and Sapienza, S. and Schwab, P. and Shokhirev, N. and Venäläinen, M.S. and Vergara-Diaz, G. and Zhang, Y. and Wang, Y. and Guan, Y. and Brunner, D. and Bonato, P. and Mangravite, L.M. and Omberg, L.
NPJ Digital Medicine 4 (1): 53. 19 March 2021

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M. and Eichner, R. and Stroh, J. and Morath, V. and Kuisl, A. and Zecha, J. and Lawatscheck, J. and Baek, K. and Garz, A.K. and Rudelius, M. and Deuschle, F.C. and Keller, U. and Lemeer, S. and Verbeek, M. and Götze, K.S. and Skerra, A. and Weber, W.A. and Buchner, J. and Schulman, B.A. and Kuster, B. and Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81 (6): 1170-1186. 18 March 2021

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R. and Hilal, T. and Schmidt, S. and Qin, B. and Schwefel, D. and Vieira-Vieira, C.H. and Mielke, T. and Bürger, J. and Loerke, J. and Amikura, K. and Flügel, T. and Ueda, T. and Selbach, M. and Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81 (6): 1200-1215. 18 March 2021

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G. and Altamirano, F. and Kim, S.Y. and Tong, D. and Ferdous, A. and Piristine, H. and Dasgupta, S. and Wang, X. and French, K.M. and Villalobos, E. and Spurgin, S.B. and Waldman, M. and Jiang, N. and May, H.I. and Hill, T.M. and Luo, Y. and Yoo, H. and Zaha, V.G. and Lavandero, S. and Gillette, T.G. and Hill, J.A.
Nature Communications 12 (1): 1684. 16 March 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L. and Jarosch, E. and Zauber, H. and Kniss, A. and Waltho, A. and Bagola, K. and von Delbrück, M. and Löhr, F. and Schulman, B.A. and Selbach, M. and Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A. and Houwaart, T. and Finzer, P. and Ehlkes, L. and Tyshaieva, A. and Damagnez, M. and Strelow, D. and Duplessis, A. and Nicolai, J. and Wienemann, T. and Tamayo, T. and Kohns Vasconcelos, M. and Hülse, L. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Däumer, M.P. and Thielen, A. and Kolbe-Busch, S. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74 (6): 1039-1046. 15 March 2021

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C. and Luecken, M.D. and Eraslan, G. and Sikkema, L. and Waghray, A. and Heimberg, G. and Kobayashi, Y. and Vaishnav, E.D. and Subramanian, A. and Smillie, C. and Jagadeesh, K.A. and Duong, E.T. and Fiskin, E. and Triglia, E.T. and Ansari, M. and Cai, P. and Lin, B. and Buchanan, J. and Chen, S. and Shu, J. and Haber, A.L. and Chung, H. and Montoro, D.T. and Adams, T. and Aliee, H. and Allon, S.J. and Andrusivova, Z. and Angelidis, I. and Ashenberg, O. and Bassler, K. and Bécavin, C. and Benhar, I. and Bergenstråhle, J. and Bergenstråhle, L. and Bolt, L. and Braun, E. and Bui, L.T. and Callori, S. and Chaffin, M. and Chichelnitskiy, E. and Chiou, J. and Conlon, T.M. and Cuoco, M.S. and Cuomo, A.S.E. and Deprez, M. and Duclos, G. and Fine, D. and Fischer, D.S. and Ghazanfar, S. and Gillich, A. and Giotti, B. and Gould, J. and Guo, M. and Gutierrez, A.J. and Habermann, A.C. and Harvey, T. and He, P. and Hou, X. and Hu, L. and Hu, Y. and Jaiswal, A. and Ji, L. and Jiang, P. and Kapellos, T.S. and Kuo, C.S. and Larsson, L. and Leney-Greene, M.A. and Lim, K. and Litviňuková, M. and Ludwig, L.S. and Lukassen, S. and Luo, W. and Maatz, H. and Madissoon, E. and Mamanova, L. and Manakongtreecheep, K. and Leroy, S. and Mayr, C.H. and Mbano, I.M. and McAdams, A.M. and Nabhan, A.N. and Nyquist, S.K. and Penland, L. and Poirion, O.B. and Poli, S. and Qi, C.C. and Queen, R. and Reichart, D. and Rosas, I. and Schupp, J.C. and Shea, C.V. and Shi, X. and Sinha, R. and Sit, R.V. and Slowikowski, K. and Slyper, M. and Smith, N.P. and Sountoulidis, A. and Strunz, M. and Sullivan, T.B. and Sun, D. and Talavera-López, C. and Tan, P. and Tantivit, J. and Travaglini, K.J. and Tucker, N.R. and Vernon, K.A. and Wadsworth, M.H. and Waldman, J. and Wang, X. and Xu, K. and Yan, W. and Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27 (3): 546-559. 2 March 2021

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P. and Birkner, T. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Mähler, A. and Weber, D. and Kochlik, B. and Balogh, A. and Wilck, N. and Boschmann, M. and Müller, D.N. and Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L. and Story, B.A. and Hernández-Malmierca, P. and Raffel, S. and Leonce, D.R. and Milbank, J. and Paulsen, M. and Demir, A. and Szu-Tu, C. and Frömel, R. and Lutz, C. and Nowak, D. and Jann, J.C. and Pabst, C. and Boch, T. and Hofmann, W.K. and Müller-Tidow, C. and Trumpp, A. and Haas, S. and Steinmetz, L.M.
Nature Communications 12 (1): 1366. 1 March 2021

Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C. and Galea, E. and Lakatos, A. and O'Callaghan, J.P. and Petzold, G.C. and Serrano-Pozo, A. and Steinhäuser, C. and Volterra, A. and Carmignoto, G. and Agarwal, A. and Allen, N.J. and Araque, A. and Barbeito, L. and Barzilai, A. and Bergles, D.E. and Bonvento, G. and Butt, A.M. and Chen, W.T. and Cohen-Salmon, M. and Cunningham, C. and Deneen, B. and De Strooper, B. and Díaz-Castro, B. and Farina, C. and Freeman, M. and Gallo, V. and Goldman, J.E. and Goldman, S.A. and Götz, M. and Gutiérrez, A. and Haydon, P.G. and Heiland, D.H. and Hol, E.M. and Holt, M.G. and Iino, M. and Kastanenka, K.V. and Kettenmann, H. and Khakh, B.S. and Koizumi, S. and Lee, C.J. and Liddelow, S.A. and MacVicar, B.A. and Magistretti, P. and Messing, A. and Mishra, A. and Molofsky, A.V. and Murai, K.K. and Norris, C.M. and Okada, S. and Oliet, S.H.R. and Oliveira, J.F. and Panatier, A. and Parpura, V. and Pekna, M. and Pekny, M. and Pellerin, L. and Perea, G. and Pérez-Nievas, B.G. and Pfrieger, F.W. and Poskanzer, K.E. and Quintana, F.J. and Ransohoff, R.M. and Riquelme-Perez, M. and Robel, S. and Rose, C.R. and Rothstein, J.D. and Rouach, N. and Rowitch, D.H. and Semyanov, A. and Sirko, S. and Sontheimer, H. and Swanson, R.A. and Vitorica, J. and Wanner, I.B. and Wood, L.B. and Wu, J. and Zheng, B. and Zimmer, E.R. and Zorec, R. and Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24 (3): 312-325. March 2021

Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Fiskin, E. and Lareau, C.A. and Ludwig, L.S. and Eraslan, G. and Liu, F. and Ring, A.M. and Xavier, R.J. and Regev, A.
Nature Biotechnology 40 (3): 374-381. March 2021

Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A. and Serfling, R. and Möller, J. and Thomas, R. and De Faveri, C. and Zabel, U. and Scarselli, M. and Beck-Sickinger, A.G. and Bock, A. and Coin, I. and Lohse, M.J. and Annibale, P.
Nature Protocols 16 (3): 1419-1451. March 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I. and Poon, E. and Henssen, A.G. and Dorado Garcia, H. and Gatti, M. and Giansanti, C. and Jamin, Y. and Ade, C.P. and Gallant, P. and Schülein-Völk, C. and Beli, P. and Richards, M. and Rosenfeldt, M. and Altmeyer, M. and Anderson, J. and Eggert, A. and Dobbelstein, M. and Bayliss, R. and Chesler, L. and Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. and Company, C. and Dramaretska, Y. and Barozzi, I. and Göhrig, A. and Kertalli, S. and Großmann, M. and Naumann, H. and Sánchez-Bailón, M.P. and Hulsman, D. and Glass, R. and Squatrito, M. and Serresi, M. and Gargiulo, G.
Cancer Discovery 11 (3): 754-777. March 2021

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang, H. and Hooper, C. and Kelly, M. and Steeples, V. and Simon, J.N. and Beglov, J. and Azad, A.J. and Leinhos, L. and Bennett, P. and Ehler, E. and Kalisch-Smith, J.I. and Sparrow, D.B. and Fischer, R. and Heilig, R. and Isackson, H. and Ehsan, M. and Patone, G. and Huebner, N. and Davies, B. and Watkins, H. and Gehmlich, K.
Basic Research in Cardiology 116 (1): 14. 26 February 2021

The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans.
Kazmierczak, M. and Farré i Díaz, C. and Ofenbauer, A. and Herzog, S. and Tursun, B.
Nucleic Acids Research 49 (4): e22. 26 February 2021

CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo.
Martín, A.L. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 49 (4): e19. 26 February 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y. and Lahmann, I. and Baum, K. and Shimojo, H. and Mourikis, P. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A. and Sieverling, L. and Nadler-Holly, M. and Ziehm, M. and Toprak, U.H. and Herrmann, C. and Ishaque, N. and Okonechnikov, K. and Gartlgruber, M. and Park, Y.G. and Wecht, E.M. and Savelyeva, L. and Henrich, K.O. and Rosswog, C. and Fischer, M. and Hero, B. and Jones, D.T.W. and Pfaff, E. and Witt, O. and Pfister, S.M. and Volckmann, Ri. and Koster, J. and Kiesel, K. and Rippe, K. and Taschner-Mandl, S. and Ambros, P. and Brors, B. and Selbach, M. and Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg, L. and Paolantoni, C. and Longhi, S. and Mulorz, M.M. and Lence, T. and Wessels, H.H. and Dassi, E. and Aiello, G. and Sutandy, F.X.R. and Scheibe, M. and Edupuganti, R.R. and Busch, A. and Möckel, M.M. and Vermeulen, M. and Butter, F. and König, J. and Notarangelo, M. and Ohler, U. and Dieterich, C. and Quattrone, A. and Soldano, A. and Roignant, J.Y.
EMBO Journal 40 (4): e104975. 15 February 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.
Goetzke, C.C. and Althof, N. and Neumaier, H.L. and Heuser, A. and Kaya, Z. and Kespohl, M. and Klingel, K. and Beling, A.
Basic Research in Cardiology 116 (1): 7. 1 February 2021

Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C. and Karaiskos, N. and Boltengagen, A. and Walentin, K. and Redo, K. and Himmerkus, N. and Bleich, M. and Potter, S.S. and Potter, A.S. and Eckardt, K.U. and Kocks, C. and Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32 (2): 291-306. February 2021

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J. and Michaelis, E. and Greuel, S. and Heynol, V. and Lehmann, A. and Radbruch, H. and Meinhardt, J. and Miller, F. and Herbst, H. and Corman, V.M. and Westermann, J. and Bullinger, L. and Horst, D. and von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103 : 628-635. February 2021

Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation.
Kubo, N. and Ishii, H. and Xiong, X. and Bianco, S. and Meitinger, F. and Hu, R. and Hocker, J.D. and Conte, M. and Gorkin, D. and Yu, M. and Li, B. and Dixon, J.R. and Hu, M. and Nicodemi, M. and Zhao, H. and Ren, B.
Nature Structural & Molecular Biology 28 (2): 152-161. February 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L. and Kny, M. and Hahn, A. and Schmidt, S. and Wundersitz, S. and Todiras, M. and Lahmann, I. and Bandyopadhyay, A. and Wollersheim, T. and Kaderali, L. and Luft, F.C. and Birchmeier, C. and Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J. and Veviurko, G. and Bennett, N.C. and Hart, D.W. and Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

Uncovering de novo gene birth in yeast using deep transcriptomics.
Blevins, W.R. and Ruiz-Orera, J. and Messeguer, X. and Blasco-Moreno, B. and Villanueva-Cañas, J.L. and Espinar, L. and Díez, J. and Carey, L.B. and Albà, M.M.
Nature Communications 12 (1): 604. 27 January 2021

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Norin, U. and Rintisch, C. and Meng, L. and Forster, F. and Ekman, D. and Tuncel, J. and Klocke, K. and Bäcklund, J. and Yang, M. and Bonner, M.Y and Lahore, G.F. and James, J. and Shchetynsky, K. and Bergquist, M. and Gjertsson, I. and Hubner, N. and Bäckdahl, L. and Holmdahl, R.
Nature Communications 12 (1): 610. 27 January 2021

On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
Schreiber, C. and Amiri, B. and Heyn, J.C.J. and Rädler, J.O. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 118 (4): e2009959118. 26 January 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Harnett, D. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Günnigmann, M. and Zinnall, U. and Vieira-Vieira, C.H. and Schaub, T. and Münster-Wandowski, A. and Bürger, J. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Ohler, U. and Beule, D. and Mielke, T. and Tarabykin, V. and Landthaler, M. and Kramer, G. and Vida, I. and Selbach, M. and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

Arterialization requires the timely suppression of cell growth.
Luo, W. and Garcia-Gonzalez, I. and Fernández-Chacón, M. and Casquero-Garcia, V. and Sanchez-Muñoz, M.S. and Mühleder, S. and Garcia-Ortega, L. and Andrade, J. and Potente, M. and Benedito, R.
Nature 589 (7842): 437-441. 21 January 2021

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum.
Kuijpers, M. and Kochlamazashvili, G. and Stumpf, A. and Puchkov, D. and Swaminathan, A. and Lucht, M.T. and Krause, E. and Maritzen, T. and Schmitz, D. and Haucke, V.
Neuron 109 (2): 299-313. 20 January 2021

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Alcalá-Vida, R. and Seguin, J. and Lotz, C. and Molitor, A.M. and Irastorza-Azcarate, I. and Awada, A. and Karasu, N. and Bombardier, A. and Cosquer, B. and Skarmeta, J.L.G. and Cassel, J.C. and Boutillier, A.L. and Sexton, T. and Merienne, K.
Nature Communications 12 (1): 364. 13 January 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Rodríguez de los Santos, M. and Rivalan, M. and David, F.S. and Stumpf, A. and Pitsch, J. and Tsortouktzidis, D. and Velasquez, L.M. and Voigt, A. and Schilling, K. and Mattei, D. and Long, M. and Vogt, G. and Knaus, A. and Fischer-Zirnsak, B. and Wittler, L. and Timmermann, B. and Robinson, P.N. and Horn, D. and Mundlos, S. and Kornak, U. and Becker, A.J. and Schmitz, D. and Winter, Y. and Krawitz, P.M.
Proceedings of the National Academy of Sciences of the United States of America 118 (2): e2014481118. 12 January 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.
Gurumayum, S. and Jiang, P. and Hao, X. and Campos, T.L. and Young, N.D. and Korhonen, P.K. and Gasser, R.B. and Bork, P. and Zhao, X.M. and He, L.J. and Chen, W.H.
Nucleic Acids Research 49 (D1): D998-D1003. 8 January 2021

SMART: recent updates, new developments and status in 2020.
Letunic, I. and Khedkar, S. and Bork, P.
Nucleic Acids Research 49 (D1): D458-D460. 8 January 2021

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.
Szklarczyk, D. and Gable, A.L. and Nastou, K.C. and Lyon, D. and Kirsch, R. and Pyysalo, S. and Doncheva, N.T. and Legeay, M. and Fang, T. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 49 (D): D605-D612. 8 January 2021

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Prinz, C. and Starke, L. and Millward, J.M. and Fillmer, A. and Delgado, P.R. and Waiczies, H. and Pohlmann, A. and Rothe, M. and Nazaré, M. and Paul, F. and Niendorf, T. and Waiczies, S.
Theranostics 11 (6): 2490-2504. 1 January 2021

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A. and Haage, V. and Yang, S. and Wegner, S. and Ersoy, B. and Ugursu, B. and Rex, A. and Kronenberg, G. and Gertz, K. and Endres, M. and Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91 : 89-104. January 2021

Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection.
Melo, E.M. and Del Sarto, J. and Vago, J.P. and Tavares, L.P. and Rago, F. and Gonçalves, A.P.F. and Machado, M.G. and Aranda-Pardos, I. and Valiate, B.V.S. and Cassali, G.D. and Pinho, V. and Sousa, L.P. and A-Gonzalez, N. and Campagnole-Santos, M.J. and Bader, M. and Santos, R.A.S. and Machado, A.V. and Ludwig, S. and Teixeira, M.M.
Pharmacological Research 163 : 105292. January 2021

USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Schwaller, F. and Bégay, V. and García-García, G. and Taberner, F.J. and Moshourab, R. and McDonald, B. and Docter, T. and Kühnemund, J. and Ojeda-Alonso, J. and Paricio-Montesinos, R. and Lechner, S.G. and Poulet, J.F.A. and Millan, J.M. and Lewin, G.R.
Nature Neuroscience 24 (1): 74-81. January 2021

Early response to first-line anti-PD-1 treatment in Hodgkin lymphoma: a PET-based analysis from the prospective, randomized phase II NIVAHL trial.
Voltin, C.A. and Mettler, J. and van Heek, L. and Goergen, H. and Müller, H. and Baues, C. and Keller, U. and Meissner, J. and Trautmann-Grill, K. and Kerkhoff, A. and Fuchs, M. and Sasse, S. and von Tresckow, B. and Dietlein, M. and Borchmann, P. and Engert, A. and Kobe, C. and Bröckelmann, P.J.
Clinical Cancer Research 27 (2): 402-407. January 2021

Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
Wulf, G.G. and Altmann, B. and Ziepert, M. and D'Amore, F. and Held, G. and Greil, R. and Tournilhac, O. and Relander, T. and Viardot, A. and Wilhelm, M. and Wilhelm, C. and Pezzutto, A. and Zijlstra, J.M. and Van Den Neste, E. and Lugtenburg, P.J. and Doorduijn, J.K. and van Gelder, M. and van Imhoff, G.W. and Zettl, F. and Braulke, F. and Nickelsen, M. and Glass, B. and Rosenwald, A. and Gaulard, P. and Loeffler, M. and Pfreundschuh, M. and Schmitz, N. and Trümper, L.
Leukemia 35 (1): 143-155. January 2021

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
Kapp-Schwoerer, S. and Weber, D. and Corbacioglu, A. and Gaidzik, V.I. and Paschka, P. and Krönke, J. and Theis, F. and Rücker, F.G. and Teleanu, M.V. and Panina, E. and Jahn, N. and Herzig, J. and Kubanek, L. and Schrade, A. and Göhring, G. and Fiedler, W. and Kindler, T and Schroeder, T. and Mayer, K.T. and Lübbert, M. and Wattad, M. and Götze, K.S. and Horst, H.A. and Koller, E. and Wulf, G. and Schleicher, J. and Bentz, M. and Krauter, J. and Bullinger, L. and Krzykalla, J. and Benner, A. and Schlenk, R.F. and Thol, F. and Heuser, M. and Ganser, A. and Döhner, H and Döhner, K.
Blood 136 (26): 3041-3050. 24 December 2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J. and Heuberger, J. and Vidal, R. and Goveas, N. and Kosel, F. and Berenguer-Llergo, A. and Kranz, A. and Wulf-Goldenberg, A. and Behrens, D. and Melcher, B. and Sauer, S. and Vieth, M. and Batlle, E. and Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Cells of the adult human heart.
Litviňuková, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Worth, C.L. and Lindberg, E.L. and Kanda, M. and Polanski, K. and Heinig, M. and Lee, M.l and Nadelmann, E.R. and Roberts, K. and Tuck, L. and Fasouli, E.S. and DeLaughter, D.M. and McDonough, B. and Wakimoto, H. and Gorham, J.M. and Samari, S. and Mahbubani, K.T. and Saeb-Parsy, K. and Patone, G. and Boyle, J.J. and Zhang, H. and Zhang, H. and Viveiros, A. and Oudit, G.Y. and Bayraktar, O. and Seidman, J.G. and Seidman, C.E. and Noseda, M. and Hubner, N. and Teichmann, S.A.
Nature 588 (7838): 466-472. 17 December 2020

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S. and Bröckelmann, P.J. and Iaccarino, I. and Garcia-Marquez, M. and Borchmann, S. and Jochims, F. and Kotrova, M. and Pal, K. and Brüggemann, M. and Hartmann, E. and Sasse, S. and Kobe, C. and Mathas, S. and Soekler, M. and Keller, U. and Bormann, M. and Zimmermann, A. and Richter, J. and Fuchs, M. and von Tresckow, B. and Borchmann, P. and Schlößer, H. and von Bergwelt-Baildon, M. and Rosenwald, A. and Engert, A. and Klapper, W.
Blood 136 (25): 2851-2863. 17 December 2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P. and Mishra, N. and Tran, F. and Bahmer, T. and Best, L. and Blase, J.I. and Bordoni, D. and Franzenburg, J. and Geisen, U. and Josephs-Spaulding, J. and Köhler, P. and Künstner, A. and Rosati, E. and Aschenbrenner, A.C. and Bacher, P. and Baran, N. and Boysen, T. and Brandt, B. and Bruse, N. and Dörr, J. and Dräger, A. and Elke, G. and Ellinghaus, D. and Fischer, J. and Forster, M. and Franke, A. and Franzenburg, S. and Frey, N. and Friedrichs, A. and Fuß, J. and Glück, A. and Hamm, J. and Hinrichsen, F. and Hoeppner, M.P. and Imm, S. and Junker, R. and Kaiser, S. and Kan, Y.H. and Knoll, R. and Lange, C. and Laue, G. and Lier, C. and Lindner, M. and Marinos, G. and Markewitz, R. and Nattermann, J. and Noth, R. and Pickkers, P. and Rabe, K.F. and Renz, A. and Röcken, C. and Rupp, J. and Schaffarzyk, A. and Scheffold, A. and Schulte-Schrepping, J. and Schunk, D. and Skowasch, D. and Ulas, T. and Wandinger, K.P. and Wittig, M. and Zimmermann, J. and Busch, H. and Hoyer, B.F. and Kaleta, C. and Heyckendorf, J. and Kox, M. and Rybniker, J. and Schreiber, S. and Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Lowenstein, E.D. and Schöwel, V. and Spuler, S. and Akalin, A. and Birchmeier, C.
Nature Communications 11 : 6375. 11 December 2020

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
Veenvliet, J.V. and Bolondi, A. and Kretzmer, H. and Haut, L. and Scholze-Wittler, M. and Schifferl, D. and Koch, F. and Guignard, L. and Kumar, A.S. and Pustet, M. and Heimann, S. and Buschow, R. and Wittler, L. and Timmermann, B. and Meissner, A. and Herrmann, B.G.
Science 370 (6522): eaba4937. 11 December 2020

Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.
Reddington, J.P. and Garfield, D.A. and Sigalova, O.M. and Karabacak Calviello, A. and Marco-Ferreres, R. and Girardot, C. and Viales, R.R. and Degner, J.F. and Ohler, U. and Furlong, E.E.M.
Developmental Cell 55 (5): 648-664. 7 December 2020

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K. and Schnöder, T.M. and Perner, F. and Herzog, C. and Meiler, A. and Krishnamoorthy, G. and Huber, N. and Mohr, J. and Edelmann-Stephan, B. and Austin, R. and Brandt, S. and Palandri, F. and Schröder, N. and Isermann, B. and Edlich, F. and Sinha, A.U. and Ungelenk, M. and Hübner, C.A. and Zeiser, R. and Rahmig, S. and Waskow, C. and Coldham, I. and Ernst, T. and Hochhaus, A. and Jilg, S. and Jost, P.J. and Mullally, A. and Bullinger, L. and Mertens, P.R. and Lane, S.W. and Mann, M. and Heidel, F.H.
Nature 588 (7836): 157-163. 3 December 2020

A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration.
Polovitskaya, M.M. and Barbini, C. and Martinelli, D. and Harms, F.L. and Cole, F.S. and Calligari, P. and Bocchinfuso, G. and Stella, L. and Ciolfi, A. and Niceta, M. and Rizza, T. and Shinawi, M. and Sisco, K. and Johannsen, J. and Denecke, J. and Carrozzo, R. and Wegner, D.J. and Kutsche, K. and Tartaglia, M. and Jentsch, T.J.
American Journal of Human Genetics 107 (6): 1062-1077. 3 December 2020

Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.
Le Poul, Y. and Xin, Y. and Ling, L. and Mühling, B. and Jaenichen, R. and Hörl, D. and Bunk, D. and Harz, H. and Leonhardt, H. and Wang, Y. and Osipova, E. and Museridze, M. and Dharmadhikari, D. and Murphy, E. and Rohs, R. and Preibisch, S. and Prud'homme, B. and Gompel, N.
Science Advances 6 (49): eabe2955. 2 December 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T. and Graf, R. and Wulf-Goldenberg, A. and Stecklum, M. and Strauß, G. and Kühn, R. and Kocks, C. and Rajewsky, K. and Chu, V.T.
Molecular Therapy 28 (12): 2621-2634. 2 December 2020

CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
Herhaus, P. and Lipkova, J. and Lammer, F. and Yakushev, I. and Vag, T. and Slotta-Huspenina, J. and Habringer, S. and Lapa, C. and Pukrop, T. and Hellwig, D. and Wiestler, B. and Buck, A.K. and Deckert, M. and Wester, H.J. and Bassermann, F. and Schwaiger, M. and Weber, W.A. and Menze, B. and Keller, U.
Journal of Nuclear Medicine 61 (12): 1765-1771. 1 December 2020

S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants.
Willers, M. and Ulas, T. and Völlger, L. and Vogl, T. and Heinemann, A.S. and Pirr, S. and Pagel, J. and Fehlhaber, B. and Halle, O. and Schöning, J. and Schreek, S. and Löber, U. and Essex, M. and Hombach, P. and Graspeuntner, S. and Basic, M. and Bleich, A. and Cloppenborg-Schmidt, K. and Künzel, S. and Jonigk, D. and Rupp, J. and Hansen, G. and Förster, R. and Baines, J.F. and Härtel, C. and Schultze, J.L. and Forslund, S.K. and Roth, J. and Viemann, D.
Gastroenterology 159 (6): 2130-2145. December 2020

Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy.
Krug, K. and Jaehnig, E.J. and Satpathy, S. and Blumenberg, L. and Karpova, A. and Anurag, M. and Miles, G. and Mertins, P. and Geffen, Y. and Tang, L.C. and Heiman, D.I. and Cao, S. and Maruvka, Y.E. and Lei, J.T. and Huang, C. and Kothadia, R.B. and Colaprico, A. and Birger, C. and Wang, J. and Dou, Y. and Wen, B. and Shi, Z. and Liao, Y. and Wiznerowicz, M. and Wyczalkowski, M.A. and Chen, X.S. and Kennedy, J.J. and Paulovich, A.G. and Thiagarajan, M. and Kinsinger, C.R. and Hiltke, T. and Boja, E.S. and Mesri, M. and Robles, A.I. and Rodriguez, H. and Westbrook, T.F. and Ding, L. and Getz, G. and Clauser, K.R. and Fenyö, D. and Ruggles, K.V. and Zhang, B. and Mani, D.R and Carr, S.A. and Ellis, M.J. and Gillette, M.A.
Cell 183 (5): 1436-1456. 25 November 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N. and Almouzni, G. and Gorski, S.A. and Aerts, S. and Amit, I. and Bertero, M.G. and Bock, C. and Bredenoord, A.L. and Cavalli, G. and Chiocca, S. and Clevers, H. and De Strooper, B. and Eggert, A. and Ellenberg, J. and Fernández, X.M. and Figlerowicz, M. and Gasser, S.M. and Hubner, N. and Kjems, J. and Knoblich, J.A. and Krabbe, G. and Lichter, P. and Linnarsson, S. and Marine, J.C. and Marioni, J. and Marti-Renom, M.A. and Netea, M.G. and Nickel, D. and Nollmann, M. and Novak, H.R. and Parkinson, H. and Piccolo, S. and Pinheiro, I. and Pombo, A. and Popp, C. and Reik, W. and Roman-Roman, S. and Rosenstiel, P. and Schultze, J.L. and Stegle, O. and Tanay, A. and Testa, G. and Thanos, D. and Theis, F.J. and Torres-Padilla, M.E. and Valencia, A. and Vallot, C. and van Oudenaarden, A. and Vidal, M. and Voet, T.
Nature 587 (7834): 377-386. 19 November 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Molinaro, A. and Bel Lassen, P. and Henricsson, M. and Wu, H. and Adriouch, S. and Belda, E. and Chakaroun, R. and Nielsen, T. and Bergh, P.O. and Rouault, C. and André, S. and Marquet, F. and Andreelli, F. and Salem, J.E. and Assmann, K. and Bastard, J.P. and Forslund, S. and Le Chatelier, E. and Falony, G. and Pons, N. and Prifti, E. and Quinquis, B. and Roume, H. and Vieira-Silva, S. and Hansen, T.H. and Pedersen, H.K. and Lewinter, C. and Sønderskov, N.B. and Køber, L. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Galan, P. and Dumas, M.E. and Raes, J. and Oppert, J.M. and Letunic, I. and Nielsen, J. and Bork, P. and Ehrlich, S.D. and Stumvoll, M. and Pedersen, O. and Aron-Wisnewsky, J. and Clément, K. and Bäckhed, F.
Nature Communications 11 (1): 5881. 18 November 2020

Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations.
Pandey, S. and Gruenbaum, A. and Kanashova, T. and Mertins, P. and Cluzel, P. and Chevrier, N.
Cell Systems 11 (5): 495-508. 18 November 2020

Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir, A. and Möller, J. and Arimont, M. and Bobkov, V. and Perpiñá-Viciano, C. and Hoffmann, C. and Inoue, A. and Heukers, R. and de Graaf, C. and Smit, M.J. and Annibale, P. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 117 (46): 29144-29154. 17 November 2020

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C. and Ritterhoff, T. and Weber, A. and Janowska, M.K. and Mustroph, M. and Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202 (10): 1445-1457. 15 November 2020

A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Kreye, J. and Reincke, S.M. and Kornau, H.C. and Sánchez-Sendin, E. and Corman, V.M. and Liu, H. and Yuan, M. and Wu, N.C. and Zhu, X. and Lee, C.C.D. and Trimpert, J. and Höltje, M. and Dietert, K. and Stöffler, L. and von Wardenburg, N. and van Hoof, S. and Homeyer, M.A. and Hoffmann, J. and Abdelgawad, A. and Gruber, A.D. and Bertzbach, L.D. and Vladimirova, D. and Li, L.Y. and Barthel, P.C. and Skriner, K. and Hocke, A.C. and Hippenstiel, S. and Witzenrath, M. and Suttorp, N. and Kurth, F. and Franke, C. and Endres, M. and Schmitz, D. and Jeworowski, L.M. and Richter, A. and Schmidt, M.L. and Schwarz, T. and Müller, M.A. and Drosten, C. and Wendisch, D. and Sander, L.E. and Osterrieder, N. and Wilson, I.A. and Prüss, H.
Cell 183 (4): 1058-1069. 12 November 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K. and Lim, E.L. and Petkovic, M. and Elizalde, S. and Birkbak, N.J. and Wilson, G.A. and Moore, D.A. and Grönroos, E. and Rowan, A. and Dewhurst, S.M. and Demeulemeester, J. and Dentro, S.C. and Horswell, S. and Au, L. and Haase, K. and Escudero, M. and Rosenthal, R. and Bakir, M.A. and Xu, H. and Litchfield, K. and Lu, W.T. and Mourikis, T.P. and Dietzen, M. and Spain, L. and Cresswell, G.D. and Biswas, D. and Lamy, P. and Nordentoft, I. and Harbst, K. and Castro-Giner, F. and Yates, L.R. and Caramia, F. and Jaulin, F. and Vicier, C. and Tomlinson, I.P.M. and Brastianos, P.K. and Cho, R.J. and Bastian, B.C. and Dyrskjøt, L. and Jönsson, G.B. and Savas, P. and Loi, S. and Campbell, P.J. and Andre, F. and Luscombe, N.M. and Steeghs, N. and Tjan-Heijnen, V.C.G. and Szallasi, Z. and Turajlic, S. and Jamal-Hanjani, M. and Van Loo, P. and Bakhoum, S.F. and Schwarz, R.F. and McGranahan, N. and Swanton, C.
Nature 587 (7832): 126-132. 5 November 2020

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S. and Hopf, L.V.M. and Bock-Bierbaum, T. and Lally, C.C.M. and Spahn, C.M.T. and Daumke, O.
Nature Communications 11 (1): 5506. 2 November 2020

The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel, B. and Czimmerer, Z. and Halasz, L. and Boto, P. and Kolostyak, Z. and Poliska, S. and Berger, W.K. and Tzerpos, P. and Nagy, G. and Horvath, A. and Hajas, G. and Cseh, T. and Nagy, A. and Sauer, S. and Francois-Deleuze, J. and Szatmari, I. and Bacsi, A. and Nagy, L.
Genes & Development 34 (21-22): 1474-1492. 1 November 2020

The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D. and Formichetti, S. and Junker, J.P. and Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16 (11): e9946. 1 November 2020

Monogenic variants in dystonia: an exome-wide sequencing study.
Zech, M. and Jech, R. and Boesch, S. and Škorvánek, M. and Weber, S. and Wagner, M. and Zhao, C. and Jochim, A. and Necpál, J. and Dincer, Y. and Vill, K. and Distelmaier, F. and Stoklosa, M. and Krenn, M. and Grunwald, S. and Bock-Bierbaum, T. and Fečíková, A. and Havránková, P. and Roth, J. and Příhodová, I. and Adamovičová, M. and Ulmanová, O. and Bechyně, K. and Danhofer, P. and Veselý, B. and Haň, V. and Pavelekova, P. and Gdovinová, Z. and Mantel, T. and Meindl, T. and Sitzberger, A. and Schröder, S. and Blaschek, A. and Roser, T. and Bonfert, M.V. and Haberlandt, E. and Plecko, B. and Leineweber, B. and Berweck, S. and Herberhold, T. and Langguth, B. and Švantnerová, J. and Minár, M. and Ramos-Rivera, G.A. and Wojcik, M.H. and Pajusalu, S. and Õunap, K. and Schatz, U.A. and Pölsler, L. and Milenkovic, I. and Laccone, F. and Pilshofer, V. and Colombo, R. and Patzer, S. and Iuso, A. and Vera, J. and Troncoso, M. and Fang, F. and Prokisch, H. and Wilbert, F. and Eckenweiler, M. and Graf, E. and Westphal, D.S. and Riedhammer, K.M. and Brunet, T. and Alhaddad, B. and Berutti, R. and Strom, T.M. and Hecht, M. and Baumann, M. and Wolf, M. and Telegrafi, A. and Person, R.E. and Zamora, F.M. and Henderson, L.B. and Weise, D. and Musacchio, T. and Volkmann, J. and Szuto, A. and Becker, J. and Cremer, K. and Sycha, T. and Zimprich, F. and Kraus, V. and Makowski, C. and Gonzalez-Alegre, P. and Bardakjian, T.M. and Ozelius, L.J. and Vetro, A. and Guerrini, R. and Maier, E. and Borggraefe, I. and Kuster, A. and Wortmann, S.B. and Hackenberg, A. and Steinfeld, R. and Assmann, B. and Staufner, C. and Opladen, T. and Růžička, E. and Cohn, R.D. and Dyment, D. and Chung, W.K. and Engels, H. and Ceballos-Baumann, A. and Ploski, R. and Daumke, O. and Haslinger, B. and Mall, V. and Oexle, K. and Winkelmann, J.
Lancet Neurology 19 (11): 908-918. November 2020

Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y. and Gilboa, T. and van Kooten, X.F. and Kobelt, D. and Huttner, D. and Stein, U. and Meller, A.
ACS Nano 14 (10): 13964-13974. 27 October 2020

A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C. and Mueller, L. and Ruzittu, S. and Mah, N. and Willnow, D. and Darrigrand, J.F. and Wilson, H. and Khosravinia, D. and Mahmoud, A.A. and Risolino, M. and Selleri, L. and Spagnoli, F.M.
Developmental Cell 55 (2): 150-162. 26 October 2020

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A. and van Rijssel, J. and Ramms, A.S. and Wild, R. and Hammer, J. and Merkel, M. and Derenbach, L. and Préau, L. and Hinkel, R. and Suarez-Martinez, I. and Schulte-Merker, S. and Vidal, R. and Sauer, S. and Kivelä, R. and Alitalo, K. and Kupatt, C. and van Buul, J.D. and le Noble, F.
Nature Communications 11 (1): 5319. 21 October 2020

Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.
Leistner, D.M. and Kränkel, N. and Meteva, D. and Abdelwahed, Y.S. and Seppelt, C. and Stähli, B.E. and Rai, H. and Skurk, C. and Lauten, A. and Mochmann, H.C. and Fröhlich, G. and Rauch-Kröhnert, U. and Flores, E. and Riedel, M. and Sieronski, L. and Kia, S. and Strässler, E. and Haghikia, A. and Dirks, F. and Steiner, J. K. and Mueller, D.N. and Volk, H.D. and Klotsche, J. and Joner, M. and Libby, P. and Landmesser, U.
European Heart Journal 41 (37): 3549-3560. 20 October 2020

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Microscopy with undetected photons in the mid-infrared.
Kviatkovsky, I. and Chrzanowski, H.M. and Avery, E.G. and Bartolomaeus, H. and Ramelow, S.
Science Advances 6 (42): eabd0264. 14 October 2020

Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan, H. and Glažar, P. and Latini, C. and Heizler, K. and Haase, J. and Hett, R. and Anders, M. and Weichmann, F. and Bruckmann, A. and Van den Berg, D. and Hüttelmaier, S. and Rajewsky, N. and Hackl, C. and Meister, G.
Nucleic Acids Research 48 (18): 10368-10382. 9 October 2020

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M. and Haas, S.A. and Franchini, P. and Xiong, P. and Simakov, O. and Kuhl, H. and Schöpflin, R. and Heller, D. and Moeinzadeh, M.H. and Heinrich, V. and Krannich, T. and Bressin, A. and Hartmann, M.F. and Wudy, S.A. and Dechmann, D.K.N. and Hurtado, A. and Barrionuevo, F.J. and Schindler, M. and Harabula, I. and Osterwalder, M. and Hiller, M. and Wittler, L. and Visel, A. and Timmermann, B. and Meyer, A. and Vingron, M. and Jiménez, R. and Mundlos, S. and Lupiáñez, D.G.
Science 370 (6513): 208-214. 9 October 2020

R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V. and Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48 (18): e105. 9 October 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G. and Custodio, J. and Kallas, T. and Agostini, F. and Wernersson, E. and Spanjaard, B. and Mota, A. and Kolbeinsdottir, S. and Gelali, E. and Crosetto, N. and Bienko, M.
Nature Biotechnology 38 (10): 1184-1193. October 2020

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Poh, J. and Ponsford, A.H. and Boyd, J. and Woodsmith, J. and Stelzl, U. and Wanker, E. and Harper, N. and MacEwan, D. and Sanderson, C.M.
Redox Biology 37 : 101686. October 2020

Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D. and Ameen, M. and Guo, H. and Abilez, O.J. and Tian, L. and Mumbach, M.R. and Diecke, S. and Qin, X. and Liu, Y. and Yang, H. and Ma, N. and Gaddam, S. and Cunningham, N.J. and Gu, M. and Neofytou, E. and Prado, M. and Hildebrandt, T.B. and Karakikes, I. and Chang, H.Y. and Wu, J.C.
Developmental Cell 54 (6): 694-709. 28 September 2020

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B. and Schmidt, M. and Weisbach, H. and Gruska, I. and Vetter, B. and Imami, K. and Ostermann, E. and Brune, W. and Selbach, M. and Hagemeier, C. and Wiebusch, L.
Nature Communications 11 (1): 4845. 24 September 2020

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S. and Klimmeck, D. and Falcone, M. and Demir, A. and Pouya, A. and Zeisberger, P. and Lutz, C. and Tinelli, M. and Bischel, O. and Bullinger, L. and Thiede, C. and Flörcken, A. and Westermann, J. and Ehninger, G. and Ho, A.D. and Müller-Tidow, C. and Gu, Z. and Herrmann, C. and Krijgsveld, J. and Trumpp, A. and Hansson, J.
Blood 136 (13): 1507-1519. 24 September 2020

SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N. and Taberner, F.J. and Rangel Rojas, D. and Moroni, M. and Omberbasic, D. and Njoo, C. and Andrieux, A. and Gupta, P. and Bali, K.K. and Herpel, E. and Faghihi, F. and Fleming, T. and Dejean, A. and Lechner, S.G. and Nawroth, P.P. and Lewin, G.R. and Kuner, R.
Neuron 107 (6): 1141-1159. 23 September 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H. and Meyerson, W.U. and Dursi, L.J. and Wang, L.B. and Dong, G. and Liang, W.W. and Weerasinghe, A. and Li, S. and Li, Y. and Kelso, S. and Saksena, G. and Ellrott, K. and Wendl, M.C. and Wheeler, D.A. and Getz, G. and Simpson, J.T. and Gerstein, M.B. and Ding, Li
Nature Communications 11 (1): 4748. 21 September 2020

Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B. and Alonso, G. and Georgana, I. and El-Jesr, M. and Martín, R. and Shair, K.H.Y. and Fischer, C. and Sauer, S. and Maluquer de Motes, C. and Alcamí, A.
Science Advances 6 (38): eabb4565. 18 September 2020

Optical mapping of cAMP signaling at the nanometer scale.
Bock, A. and Annibale, P. and Konrad, C. and Hannawacker, A. and Anton, S.E. and Maiellaro, I. and Zabel, U. and Sivaramakrishnan, S. and Falcke, M. and Lohse, M.J.
Cell 182 (6): 1519-1530. 17 September 2020

Oxidative metabolism drives immortalization of neural stem cells during tumorigenesis.
Bonnay, F. and Veloso, A. and Steinmann, V. and Köcher, T. and Abdusselamoglu, M.D. and Bajaj, S. and Rivelles, E. and Landskron, L. and Esterbauer, H. and Zinzen, R.P. and Knoblich, J.A.
Cell 182 (6): 1490-1507. 17 September 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling.
Zhang, J.Z. and Lu, T.W. and Stolerman, L.M. and Tenner, B. and Yang, J.R. and Zhang, J.F. and Falcke, M. and Rangamani, P. and Taylor, S.S. and Mehta, S. and Zhang, J.
Cell 182 (6): 1531-1544. 17 September 2020

Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U. and Kleinsorge, M. and Roos, L. and Yigit, G. and Li, Y. and Barbarics, B. and El-Battrawy, I. and Lan, H. and Tiburcy, M. and Hindmarsh, R. and Lenz, C. and Salinas, G. and Diecke, S. and Müller, C. and Adham, I. and Altmüller, J. and Nürnberg, P. and Paul, T. and Zimmermann, W.H. and Hasenfuss, G. and Wollnik, B. and Cyganek, L.
Circulation 142 (11): 1059-1076. 15 September 2020

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf, R.Z. and Saez, B. and Sharda, A. and van Gastel, N. and Yu, V.W.C. and Baryawno, N. and Scadden, E.W. and Acharya, S. and Chattophadhyay, S. and Huang, C. and Viswanathan, V. and S'aulis, D. and Cobert, J. and Sykes, D.B. and Keibler, M.A. and Das, S. and Hutchinson, J.N. and Churchill, M. and Mukherjee, S. and Lee, D. and Mercier, F. and Doench, J. and Bullinger, L. and Logan, D.J. and Schreiber, S. and Stephanopoulos, G. and Rizzo, W.B. and Scadden, D.T.
Blood 136 (11): 1303-1316. 10 September 2020

Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W. and Shang, F. and Wang, X. and Fanti, A.K. and Greco, A. and Busch, K. and Klapproth, K. and Zhang, Q. and Quedenau, C. and Sauer, S. and Feyerabend, T.B. and Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27 (3): 383-395. 3 September 2020

Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C. and Buracchi, C. and Arcangeli, S. and Galimberti, S. and Valsecchi, M.G. and Perriello, V.M. and Rasko, T. and Alberti, G. and Magnani, C.F. and Cappuzzello, C. and Lundberg, F. and Pande, A. and Dastoli, G. and Introna, M. and Serafini, M. and Biagi, E. and Izsvák, Z. and Biondi, A. and Tettamanti, S.
Molecular Therapy 28 (9): 1974-1986. 2 September 2020

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A. and Carlo-Spiewok, A.S. and Malik, A.R. and Rothe, M. and Schipke, C.G. and Peters, O. and Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 16 (9): 1248-1258. September 2020

Blood pressure and angiogenic markers in pregnancy: contributors to pregnancy-induced hypertension and offspring cardiovascular risk.
Birukov, A.. and Herse, F. and Nielsen, J.H. and Kyhl, H.B. and Golic, M. and Kräker, K. and Haase, N. and Busjahn, A. and Bruun, S. and Jensen, B.L. and Müller, D.N. and Jensen, T.K. and Christesen, H.T. and Andersen, M.S. and Jørgensen, J.S. and Dechend, R. and Andersen, L.B.
Hypertension 76 (3): 901-909. September 2020

Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. and Isbilir, A. and Sungkaworn, T. and Osberg, B. and Karathanasis, C. and Sunkara, V. and Grushevskyi, E.O. and Bock, A. and Annibale, P. and Heilemann, M. and Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16 (9): 946-954. September 2020

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M. and Alpaugh, M. and Sciacca, G. and Saint-Pierre, M. and Masnata, M. and Denis, H.L. and Lévesque, S.A. and Herrmann, F. and Bazenet, C. and Garneau, A.P. and Isenring, P. and Truant, R. and Oueslati, A. and Gould, P.V. and Ast, A. and Wanker, E.E. and Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 26 (9): 5441–5463. September 2020

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I. and Beaton, N. and Bruderer, R. and Knobloch, T. and Barbisan, C. and Chandat, L. and Sudau, A. and Siepe, I. and Rinner, O. and de Souza, N. and Picotti, P. and Reiter, L.
Nature Communications 11 (1): 4200. 21 August 2020

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L. and Panayotis, N. and Alber, S. and Dagan, S.Y. and Okladnikov, N. and Koppel, I. and Di Pizio, A. and Song, D.A. and Tzur, Y. and Terenzio, M. and Rishal, I. and Gordon, D. and Rother, F. and Hartmann, E. and Bader, M. and Fainzilber, M.
Science 369 (6505): 842-846. 14 August 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L. and Klaus, A. and Maas, J. and Morin-Poulard, I. and Weijts, B. and Schulte-Merker, S. and Berezikov, E. and Junker, J.P. and Robin, C.
Blood 136 (7): 831-844. 13 August 2020

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Biederstädt, A. and Hassan, Z. and Schneeweis, C. and Schick, M. and Schneider, L. and Muckenhuber, A. and Hong, Y. and Siegers, G. and Nilsson, L. and Wirth, M. and Dantes, Z. and Steiger, K. and Schunck, K. and Langston, S. and Lenhof, H.P. and Coluccio, A. and Orben, F. and Slawska, J. and Scherger, A. and Saur, D. and Müller, S. and Rad, R. and Weichert, W. and Nilsson, J. and Reichert, M. and Schneider, G. and Keller, U.
Gut 69 (8): 1472-1482. August 2020

Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L. and Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27 (8): 717-725. August 2020

High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Hehlmann, R. and Voskanyan, A. and Lauseker, M. and Pfirrmann, M. and Kalmanti, L. and Rinaldetti, S. and Kohlbrenner, K. and Haferlach, C. and Schlegelberger, B. and Fabarius, A. and Seifarth, W. and Spieß, B. and Wuchter, P. and Krause, S. and Kolb, H.J. and Neubauer, A. and Hossfeld, D.K. and Nerl, C. and Gratwohl, A. and Baerlocher, G.M. and Burchert, A. and Brümmendorf, T.H. and Hasford, J. and Hochhaus, A. and Saußele, S. and Baccarani, M.
Leukemia 34 (8): 2074-2086. August 2020

Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M. and Ferreira, D.G. and Batalha, V.L. and Marques-Morgado, I. and Coelho, J.E. and Pereira, P. and Gomes, R. and Pinto, A. and Carvalho, S. and Canas, P.M. and Cuvelier, L. and Buée-Scherrer, V. and Faivre, E. and Baqi, Y. and Müller, C.E. and Pimentel, J. and Schiffmann, S.N. and Buée, L. and Bader, M. and Outeiro, T.F. and Blum, D. and Cunha, R.A. and Marie, H. and Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25 (8): 1876-1900. August 2020

Norman M. Kaplan: January 2, 1931-April 5, 2020.
Townsend, R.R. and DiPette, D.J. and Luft, F.C. and Weinberger, M.H. and Ram, V.
Hypertension 76 (2): 291-293. August 2020

Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
Preussner, M. and Gao, Q. and Morrison, E. and Herdt, O. and Finkernagel, F. and Schumann, M. and Krause, E. and Freund, C. and Chen, W. and Heyd, F.
Genome Biology 21 (1): 186. 29 July 2020

Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H. and Franz, A. and Jung, M. and Weickmann, S. and Ralla, B. and Kilic, E. and Stephan, C. and Fendler, A. and Jung, K.
Theranostics 10 (20): 9268-9279. 23 July 2020

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K. and Kase, J. and Dörr, J.R. and Trescher, S. and Bhattacharya, A. and Yu, Y. and Wailes, E.M. and Fan, D.N.Y. and Lohneis, P. and Milanovic, M. and Lau, A. and Lenze, D. and Hummel, M. and Chapuy, B. and Leser, U. and Reimann, M. and Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M. and Markó, L. and Schächterle, C. and Tsvetkov, D. and Cui, Y. and Maghsodi, S. and Bartolomaeus, T.U.P. and Maass, P.G. and Zühlke, K. and Gregersen, N. and Hübner, N. and Hodge, R. and Mühl, A. and Pohl, B. and Molé-Illas, R. and Geelhaar, A. and Walter, S. and Napieczynska, H. and Schelenz, S. and Taube, M. and Heuser, A. and Anistan, Y.M. and Qadri, F. and Todiras, M. and Plehm, R. and Popova, E. and Langanki, R. and Eichhorst, J. and Lehmann, M. and Wiesner, B. and Russwurm, M. and Forslund, S.K. and Kamer, I. and Müller, D.N. and Gollasch, M. and Aydin, A. and Bähring, S. and Bader, M. and Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
Toboso-Navasa, A. and Gunawan, A. and Morlino, G. and Nakagawa, R. and Taddei, A. and Damry, D. and Patel, Y. and Chakravarty, P. and Janz, M. and Kassiotis, G. and Brink, R. and Eilers, M. and Calado, D.P.
Journal of Experimental Medicine 217 (7): e20191933. 6 July 2020

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
Conte, M. and Fiorillo, L. and Bianco, S. and Chiariello, A.M. and Esposito, A. and Nicodemi, M.
Nature Communications 11 (1): 3289. 3 July 2020

VarFish: comprehensive DNA variant analysis for diagnostics and research.
Holtgrewe, M. and Stolpe, O. and Nieminen, M. and Mundlos, S. and Knaus, A. and Kornak, U. and Seelow, D. and Segebrecht, L. and Spielmann, M. and Fischer-Zirnsak, B. and Boschann, F. and Scholl, U. and Ehmke, N. and Beule, D.
Nucleic Acids Research 48 (W1): W162-W169. 2 July 2020

Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J. and Marczenke, M. and Rudolph, I.M. and Nielsen, R. and Storm, T. and Ilsoe Christensen, E. and Diecke, S. and Emma, F. and Willnow, T.E.
Kidney International 98 (1): 159-167. July 2020

AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I. and Roux, P.F. and de Freitas, J.A.N.L.F. and Robinson, L. and Doré, G. and Sun, B. and Belenki, D. and Milanovic, M. and Herbig, U. and Schmitt, C.A. and Gil, J. and Bischof, O.
Nature Cell Biology 22 (7): 842-855. July 2020

Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas.
Ruzittu, S. and Willnow, D. and Spagnoli, F.M.
Cold Spring Harbor Perspectives in Biology 12 (7): a035626. July 2020

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A. and Rousselle, A. and Klocke, J. and Bachmann, S. and Popovic, S. and Bontscho, J. and Schmidt-Ott, K.M. and Siffrin, V. and Jerke, U. and Ashraf, M.I. and Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Dynamic conjugate F-SHARP microscopy.
Papadopoulos, I.N. and Jouhanneau, J.S. and Takahashi, N. and Kaplan, D. and Larkum, M. and Poulet, J. and Judkewitz, B.
Light: Science & Applications 9 (1): 110. 30 June 2020

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T. and Yasuda, T. and Ronen, J. and Wirtz, T. and Weber, T. and Sack, U. and Caeser, R. and Zhang, J. and Li, X. and Chu, V.T. and Jauch, A. and Unger, K. and Hodson, D.J. and Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117 (25): 14421-14432. 23 June 2020

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F. and Fink, C. and Hüttemeister, J. and Kirchner, M. and Radke, M.H. and Lopez Carballo, J. and Wagner, E. and Kohl, T. and Lehnart, S.E. and Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M. and Fischer, A. and Goetzke, C.C. and Neumaier, H.L. and Sauter, M. and Kespohl, M. and Müller, A.M. and Meckes, C. and Salbach, C. and Schenk, M. and Heuser, A. and Landmesser, U. and Weiner, J. and Meder, B. and Lehmann, L. and Kratzer, A. and Klingel, K. and Katus, H.A. and Kaya, Z. and Beling, A.
Circulation 141 (23): 1885-1902. 9 June 2020

The sensory coding of warm perception.
Paricio-Montesinos, R. and Schwaller, F. and Udhayachandran, A. and Rau, F. and Walcher, J. and Evangelista, R. and Vriens, J. and Voets, T. and Poulet, J.F.A. and Lewin, G.R.
Neuron 106 (5): 830-841. 3 June 2020

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N. and Foster, D.J. and Cunningham, M.W. and Bercher, J. and Nguyen, T. and Shulga-Morskaya, S. and Milstein, S. and Shaikh, S. and Rollins, J. and Golic, M. and Herse, F. and Kräker, K. and Bendix, I. and Serdar, M. and Napieczynska, H. and Heuser, A. and Gellhaus, A. and Thiele, K. and Wallukat, G. and Müller, D.N. and LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130 (6): 2928-2942. 1 June 2020

Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J. and Goergen, H. and Keller, U. and Meissner, J. and Ordemann, R. and Halbsguth, T.V. and Sasse, S. and Sökler, M. and Kerkhoff, A. and Mathas, S. and Hüttmann, A. and Bormann, M. and Zimmermann, A. and Mettler, J. and Fuchs, M. and von Tresckow, B. and Baues, C. and Rosenwald, A. and Klapper, W. and Kobe, C. and Borchmann, P. and Engert, A.
JAMA Oncology 6 (6): 872-880. June 2020

A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
Kaminski, M.M. and Alcantar, M.A. and Lape, I.T. and Greensmith, R. and Huske, A.C. and Valeri, J.A. and Marty, F.M. and Klämbt, V. and Azzi, J. and Akalin, E. and Riella, L.V. and Collins, J.J.
Nature Biomedical Engineering 4 (6): 601-609. June 2020

Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes.
Lekva, T. and Sugulle, M. and Moe, K. and Redman, C. and Dechend, R. and Staff, A.C.
Hypertension 75 (6): 1513-1522. June 2020

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E. and Lafzi, A. and Moutinho, C. and Ziegenhain, C. and McCarthy, D.J. and Álvarez-Varela, A. and Batlle, E. and Sagar, and Grün, D. and Lau, J.K. and Boutet, S.C. and Sanada, C. and Ooi, A. and Jones, R.C. and Kaihara, K. and Brampton, C. and Talaga, Y. and Sasagawa, Y. and Tanaka, K. and Hayashi, T. and Braeuning, C. and Fischer, C. and Sauer, S. and Trefzer, T. and Conrad, C. and Adiconis, X. and Nguyen, L.T. and Regev, A. and Levin, J.Z. and Parekh, S. and Janjic, A. and Wange, L.E. and Bagnoli, J.W. and Enard, W. and Gut, M. and Sandberg, R. and Nikaido, I. and Gut, I. and Stegle, O. and Heyn, H.
Nature Biotechnology 38 (6): 747-755. June 2020

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Uroda, T. and Chillón, I. and Annibale, P. and Teulon, J.M. and Pessey, O. and Karuppasamy, M. and Pellequer, J.L. and Marcia, M.
Nature Protocols 15 (6): 2107-2139. June 2020

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Vieira-Silva, S. and Falony, G. and Belda, E. and Nielsen, T. and Aron-Wisnewsky, J. and Chakaroun, R. and Forslund, S.K. and Assmann, K. and Valles-Colomer, M. and Nguyen, T..D. and Proost, S. and Prifti, E. and Tremaroli, V. and Pons, N. and Le Chatelier, E. and Andreelli, F. and Bastard, J.P. and Coelho, L.P. and Galleron, N. and Hansen, T.H. and Hulot, J.S. and Lewinter, C. and Pedersen, H.K. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Søndertoft, N.B. and Touch, S. and Dumas, M.E. and Ehrlich, S.D. and Galan, P. and Gøtze, J.P. and Hansen, T. and Holst, J.J. and Køber, L. and Letunic, I. and Nielsen, J. and Oppert, J.M. and Stumvoll, M. and Vestergaard, H. and Zucker, J.D. and Bork, P. and Pedersen, O. and Bäckhed, F. and Clément, K. and Raes, J.
Nature 581 (7808): 310-315. 21 May 2020

Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C. and Chen, X. and Planells-Cases, R. and Chu, J. and Wang, L. and Cao, L. and Li, Z. and López-Cayuqueo, K.I. and Xie, Y. and Ye, S. and Wang, X. and Ullrich, F. and Ma, S. and Fang, Y. and Zhang, X. and Qian, Z. and Liang, X. and Cai, S.Q. and Jiang, Z. and Zhou, D. and Leng, Q. and Xiao, T.S. and Lan, K. and Yang, Ji. and Li, H. and Peng, C. and Qiu, Z. and Jentsch, T.J. and Xiao, H.
Immunity 52 (5): 767-781. 19 May 2020

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S. and Gimber, N. and Deuschel, D. and Stuhlmann, T. and Puchkov, D. and Farsi, Z. and Ludwig, C.F. and Novarino, G. and López-Cayuqueo, K.I. and Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39 (9): e103358. 4 May 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. and Wagner, L.K. and Li, H. and Dörr, D. and Medaglia, C. and Paul, F. and Shemer, A. and Jung, S. and Yona, S. and Mack, M. and Leutz, A. and Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S. and Alanis-Lobato, G. and Pribyl, J. and Raskó, T. and Tichy, B. and Mikulasek, K. and Tsagiopoulou, M. and Oppelt, J. and Kastrinaki, G. and Lefaki, M. and Singh, M. and Zink, A. and Chondrogianni, N. and Psomopoulos, F. and Prigione, A. and Ivics, Z. and Pospisilova, S. and Skladal, P. and Izsvák, Z. and Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32 : 101458. May 2020

Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.
Maistrenko, O.M. and Mende, D.R. and Luetge, M. and Hildebrand, F. and Schmidt, T.S.B. and Li, S.S. and Rodrigues, J.F.M. and von Mering, C. and Pedro Coelho, L. and Huerta-Cepas, J. and Sunagawa, S. and Bork, P.
ISME Journal 14 (5): 1247-1259. May 2020

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Sungnak, W. and Huang, N. and Bécavin, C. and Berg, M. and Queen, R. and Litvinukova, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Sampaziotis, F. and Worlock, K.B. and Yoshida, M. and Barnes, J.L.
Nature Medicine 26 (5): 681-687. May 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A. and Kang, M.C. and Yang, W.M. and Hwang, W.M. and Kim, S.S. and Hong, S.H. and Heo, J.I. and Vijyakumar, A. and Pereira de Moura, L. and Uner, A. and Huang, H. and Lee, S.H. and Lima, I.S. and Park, K.S. and Kim, M.S. and Dagon, Y. and Willnow, T.E. and Aroda, V. and Ciaraldi, T.P. and Henry, R.R. and Kim, Y.B.
Nature Communications 11 (1): 2024. 24 April 2020

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N. and McKenzie, S. and Beed, P. and English, D.F. and Oldani, S. and Tukker, J.J. and Buzsáki, G. and Schmitz, D.
Nature Communications 11 (1): 1947. 23 April 2020

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M. and Ruiz-Orera, J. and Albà, M.M. and Eyras, E.
Nature Communications 11 (1): 1768. 14 April 2020

B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L. and Park, J.K. and Henke, N. and Rong, S. and Balogh, A. and Klamer, S. and Bartolomaeus, H. and Wilck, N. and Ruland, J. and Forslund, S.K. and Luft, F.C. and Dechend, R. and Müller, D.N.
Cardiovascular Research 116 (5): 1059-1070. 1 April 2020

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha, S. and Baurecht, H. and Novak, N. and Rodríguez, E. and Bej, S. and Mayr, G. and Emmert, H. and Stölzl, D. and Gerdes, S. and Degenhardt, F. and Hübenthal, M. and Ellinghaus, E. and Jung, E.S. and Kässens, J.C. and Wienbrandt, L. and Lieb, W. and Müller-Nurasyid, M. and Hotze, M. and Dand, N. and Grosche, S. and Marenholz, I. and Arnold, A. and Homuth, G. and Schmidt, C.O. and Wehkamp, U. and Nöthen, M.M. and Hoffmann, P. and Paternoster, L. and Standl, M. and Bønnelykke, K. and Ahluwalia, T.S. and Bisgaard, H. and Peters, A. and Gieger, C. and Waldenberger, M. and Schulz, H. and Strauch, K. and Werfel, T. and Lee, Y.A. and Wolfien, M. and Rosenstiel, P. and Wolkenhauer, O. and Schreiber, St. and Franke, A. and Weidinger, S. and Ellinghaus, D.
Journal of Allergy and Clinical Immunology 145 (4): 1208-1218. April 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G. and Roeschert, I. and Prinz, F. and Baluapuri, A. and Silveira Vidal, R. and Schülein-Völk, C. and Chang, Y.C. and Ade, C.P. and Mastrobuoni, G. and Girard, C. and Kumar, A. and Wortmann, L. and Walz, S. and Lührmann, R. and Kempa, S. and Kuster, B. and Wolf, E. and Mumberg, D. and Eilers, M.
Molecular Cell 77 (6): 1322-1339. 19 March 2020

Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A. and Gisevius, B. and Hirschberg, S. and Yissachar, N. and Stangl, G.I. and Eilers, E. and Bader, V. and Haase, S. and Kaisler, J. and David, C. and Schneider, R. and Troisi, R. and Zent, D. and Hegelmaier, T. and Dokalis, N. and Gerstein, S. and Del Mare-Roumani, S. and Amidror, S. and Staszewski, O. and Poschmann, G. and Stühler, K. and Hirche, F. and Balogh, A. and Kempa, S. and Träger, P. and Zaiss, M.M. and Holm, J.B. and Massa, M.G. and Nielsen, H.B. and Faissner, A. and Lukas, C. and Gatermann, S.G. and Scholz, M. and Przuntek, H. and Prinz, M. and Forslund, S.K. and Winklhofer, K.F. and Müller, D.N. and Linker, R.A. and Gold, R. and Haghikia, A.
Cell 180 (6): 1067-1080. 19 March 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C. and Müller, M. and Pak, H.S. and Harnett, D. and Huber, F. and Grun, D. and Leleu, M. and Auger, A. and Arnaud, M. and Stevenson, B.J. and Michaux, J. and Bilic, I. and Hirsekorn, A. and Calviello, L. and Simó-Riudalbas, L. and Planet, E. and Lubiński, J. and Bryśkiewicz, M. and Wiznerowicz, M. and Xenarios, I. and Zhang, L. and Trono, D. and Harari, A. and Ohler, U. and Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11 (1): 1293. 10 March 2020

CRISPLD1: a novel conserved target in the transition to human heart failure.
Khadjeh, S. and Hindmarsh, V. and Weber, F. and Cyganek, L. and Vidal, R.O. and Torkieh, S. and Streckfuss-Bömeke, K. and Lbik, D. and Tiburcy, M. and Mohamed, B.A. and Bonn, S. and Toischer, K. and Hasenfuss, G.
Basic Research in Cardiology 115 (3): 27. 7 March 2020

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K. and Jung, M. and Foinquinos, A. and San José, G. and Beaumont, J. and Bock, K. and Grote-Levi, L. and Xiao, K. and Bär, C. and Pfanne, A. and Just, A. and Zimmer, K. and Ngoy, S. and López, B. and Ravassa, S. and Samolovac, S. and Janssen-Peters, H. and Remke, J. and Scherf, K. and Dangwal, S. and Piccoli, M.T. and Kleemiss, F. and Kreutzer, F.P. and Kenneweg, F. and Leonardy, J. and Hobuß, L. and Santer, L. and Do, Q.T. and Geffers, R. and Braesen, J.H. and Schmitz, J. and Brandenberger, C. and Müller, D.N. and Wilck, N. and Kaever, V. and Bähre, H. and Batkai, S. and Fiedler, J. and Alexander, K.M. and Wertheim, B.M. and Fisch, S. and Liao, R. and Diez, J. and González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort.
Aglago, E.K. and Huybrechts, I. and Murphy, N. and Casagrande, C. and Nicolas, G. and Pischon, T. and Fedirko, V. and Severi, G. and Boutron-Ruault, M.C. and Fournier, A. and Katzke, V. and Kühn, T. and Olsen, A. and Tjønneland, A. and Dahm, C.C. and Overvad, K. and Lasheras, C. and Agudo, A. and Sánchez, M.J. and Amiano, P. and Huerta, J.M. and Ardanaz, E. and Perez-Cornago, A. and Trichopoulou, A. and Karakatsani, A. and Martimianaki, G. and Palli, D. and Pala, V. and Tumino, R. and Naccarati, A. and Panico, S. and Bueno-de-Mesquita, B. and May, A. and Derksen, J.W.G. and Hellstrand, S. and Ohlsson, B. and Wennberg, M. and Van Guelpen, B. and Skeie, G. and Brustad, M. and Weiderpass, E. and Cross, A.J. and Ward, H. and Riboli, E. and Norat, T. and Chajes, V. and Gunter, M.J.
Clinical Gastroenterology and Hepatology 18 (3): 654-666. March 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M. and Menzel, L. and Grau, M. and Vion, A.C. and Anagnostopoulos, I. and Zapukhlyak, M. and Gerlach, K. and Kammertöns, T. and Hehlgans, T. and Zschummel, M. and Lenz, G. and Gerhardt, H. and Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability.
Kornau, H.C. and Kreye, J. and Stumpf, A. and Fukata, Y. and Parthier, D. and Sammons, R.P. and Imbrosci, B. and Kurpjuweit, S. and Kowski, A.B. and Fukata, M. and Prüss, H. and Schmitz, D.
Annals of Neurology 87 (3): 405-418. March 2020

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S. and Lim, E.L. and Horswell, S. and Haase, K. and Huebner, A. and Dietzen, M. and Mourikis, T.P. and Watkins, T.B.K. and Rowan, A. and Dewhurst, S.M. and Birkbak, N.J. and Wilson, G.A. and Van Loo, P. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature Genetics 52 (3): 283-293. March 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

Pan-cancer analysis of whole genomes.

Nature 578 (7793): 82-93. 6 February 2020

Genomic basis for RNA alterations in cancer.
Calabrese, C. and Davidson, N.R. and Demircioğlu, D. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, Q. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Huska, M.R. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
Nature 578 (7793): 129-136. 6 February 2020

Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M. and Fischer, C. and Urzi, A. and Vidal, R. and Kunz, S. and Ruffault, P.L. and Kabuss, L. and Hube, I. and Gazzerro, E. and Birchmeier, C. and Spuler, S. and Sauer, S. and Gouti, M.
Cell Stem Cell 26 (2): 172-186. 6 February 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y. and Chen, F. and Fonseca, N.A. and He, Y. and Fujita, M. and Nakagawa, H. and Zhang, Z. and Brazma, A. and Creighton, C.J.
Nature Communications 11 (1): 736. 5 February 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A. and Kny, M. and Pablo-Tortola, C. and Todiras, M. and Willenbrock, M. and Schmidt, S. and Schmoeckel, K. and Jorde, I. and Nowak, M. and Jarosch, E. and Sommer, T. and Bröker, B.M. and Felix, S.B. and Scheidereit, C. and Weber-Carstens, S. and Butter, C. and Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel, J. and Hansen, C.E. and Bettoni, C. and Vogt, M.A. and Lembrich, B. and Natsagdorj, R. and Huber, G. and Brands, J. and Schmidt, K. and Assmann, J.C. and Stölting, I. and Saar, K. and Sedlacik, J. and Fiehler, J. and Ludewig, P. and Wegmann, M. and Feller, N. and Richter, M. and Müller-Fielitz, H. and Walther, T. and König, G.M. and Kostenis, E. and Raasch, W. and Hübner, N. and Gass, P. and Offermanns, S. and de Wit, C. and Wagner, C.A. and Schwaninger, M.
Proceedings of the National Academy of Sciences of the United States of America 117 (3): 1753-1761. 21 January 2020

Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D. and Mani, D.C. and Satpathy, S. and Fereshetian, S. and Gasser, J.A. and Svinkina, T. and Olive, M.E. and Ebert, B.L. and Mertins, P. and Carr, S.A.
Nature Communications 11 (1): 359. 17 January 2020

A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
Galupa, R. and Nora, E.P. and Worsley-Hunt, R. and Picard, C. and Gard, C. and van Bemmel, J.G. and Servant, N. and Zhan, Y. and El Marjou, F. and Johanneau, C. and Diabangouaya, P. and Le Saux, A. and Lameiras, S. and Pipoli da Fonseca, J. and Loos, F. and Gribnau, J. and Baulande, S. and Ohler, U. and Giorgetti, L. and Heard, E.
Molecular Cell 77 (2): 352-367. 16 January 2020

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J. and Mahnke, N.A. and Hofman, Z.L.M. and Maat, S.d. and Wu, J. and Bonnekoh, H. and Pengelly, R.J. and Ennis, S. and Holloway, J.W. and Kirchner, M. and Mertins, P. and Church, M.K. and Maurer, M. and Maas, C. and Krause, K.
Nature Communications 11 (1): 179. 10 January 2020

proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Mende, D.R. and Letunic, I. and Maistrenko, O.M. and Schmidt, T.S.B. and Milanese, A. and Paoli, L. and Hernández-Plaza, A. and Orakov, A.N. and Forslund, S.K. and Sunagawa, S. and Zeller, G. and Huerta-Cepas, J. and Coelho, L.P. and Bork, P.
Nucleic Acids Research 48 (D1): D621-D625. 8 January 2020

A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L. and Miskey, C. and Zuliani, C. and Querques, I. and Kapitonov, V. and Laukó, A. and Fehér, A. and Palazzo, A. and Diem, T. and Lustig, J. and Sebe, A. and Wang, Y. and Dinnyés, A. and Izsvák, Z. and Barabas, O. and Ivics, Z.
Nucleic Acids Research 48 (1): 316-331. 1 January 2020

Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Dusek, P. and Mekle, R. and Skowronska, M. and Acosta-Cabronero, J. and Huelnhagen, T. and Robinson, S.D. and Schubert, F. and Deschauer, M. and Els, A. and Ittermann, B. and Schottmann, G. and Madai, V.I. and Paul, F. and Klopstock, T. and Kmiec, T. and Niendorf, T. and Wuerfel, J. and Schneider, S.A.
Movement Disorders 35 (1): 142-150. January 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

Statins reverse postpartum cardiovascular dysfunction in a rat model of preeclampsia.
Kräker, K. and O'Driscoll, J.M. and Schütte, T. and Herse, F. and Patey, O. and Golic, M. and Geisberger, S. and Verlohren, S. and Birukov, A. and Heuser, A. and Mueller, D.N. and Thilaganathan, B. and Dechend, R. and Haase, N.
Hypertension 75 (1): 202-210. January 2020

Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
Pivovarova-Ramich, O. and Markova, M. and Weber, D. and Sucher, S. and Hornemann, S. and Rudovich, N. and Raila, J. and Sunaga-Franze, D. and Sauer, S. and Rohn, S. and Pfeiffer, A.F.H. and Grune, T.
Redox Biology 29 (2): 101397. January 2020

Phosphorylation of RAB7 by TBK1/IKKε regulates innate immune signaling in triple negative breast cancer.
Ritter, J.L. and Zhu, Z. and Thai, T.C. and Mahadevan, N.R. and Mertins, P. and Knelson, E.H. and Piel, B.P. and Han, S. and Jaffe, J.D. and Carr, S.A. and Barbie, D.A. and Barbie, T.U.
Cancer Research 80 (1): 44-56. January 2020

Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent.
Serfozo, P. and Wysocki, J. and Gulua, G. and Schulze, A. and Ye, M. and Liu, P. and Jin, J. and Bader, M. and Myöhänen, T. and García-Horsman, J.A. and Batlle, D.
Hypertension 75 (1): 173-182. January 2020

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A. and Escobar Fernandez, H. and Karaiskos, N. and Grunwald, S.A. and Metzler, E. and Kieshauer, J. and Sauer, S. and Pasemann, D. and Malfatti, E. and Mompoint, D. and Quijano-Roy, S. and Boltengagen, A. and Schneider, J. and Schülke, M. and Kunz, S. and Carlier, R. and Birchmeier, C. and Amthor, H. and Spuler, A. and Kocks, C. and Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

Gene expression cartography.
Nitzan, M. and Karaiskos, N. and Friedman, N. and Rajewsky, N.
Nature 576 (7785): 132-137. 5 December 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Wang, X. and Eichelbaum, K. and Sadewasser, A. and Husic, I. and Paki, K. and Budt, M. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

Long-term effects of Na(+)/Ca(2+) exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Primessnig, U. and Bracic, T. and Levijoki, J. and Otsomaa, L. and Pollesello, P. and Falcke, M. and Pieske, B. and Heinzel, F.R.
European Journal of Heart Failure 21 (12): 1543-1552. December 2019

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Csaba, Z. and Verdonk, F. and Montané, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Baud, O. and Rowitch, D. and Miron, V. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
Brain 142 (12): 3806-3833. December 2019

Gene expression changes and community turnover differentially shape the global ocean metatranscriptome.
Salazar, G. and Paoli, L. and Alberti, A. and Huerta-Cepas, J. and Ruscheweyh, H.J. and Cuenca, M. and Field, C.M. and Coelho, L.P. and Cruaud, C. and Engelen, S. and Gregory, A.C. and Labadie, K. and Marec, C. and Pelletier, E. and Royo-Llonch, M. and Roux, S. and Sánchez, P. and Uehara, H. and Zayed, A.A. and Zeller, G. and Carmichael, M. and Dimier, C. and Ferland, J. and Kandels, S. and Picheral, M. and Pisarev, S. and Poulain, J. and Acinas, S.G. and Babin, M. and Bork, P. and Bowler, C. and de Vargas, C. and Guidi, L. and Hingamp, P. and Iudicone, D. and Karp-Boss, L. and Karsenti, E. and Ogata, H. and Pesant, S. and Speich, S. and Sullivan, M.B. and Wincker, P. and Sunagawa, S.
Cell 179 (5): 1068-1083. 14 November 2019

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Schewe, J. and Seidel, E. and Forslund, S. and Marko, L. and Peters, J. and Muller, D.N. and Fahlke, C. and Stölting, G. and Scholl, U.
Nature Communications 10 (1): 5155. 14 November 2019

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X. and You, X. and Langer, J.D. and Hou, J. and Rupprecht, F. and Vlatkovic, I. and Quedenau, C. and Tushev, G. and Epstein, I. and Schaefke, B. and Sun, W. and Fang, L. and Li, G. and Hu, Y. and Schuman, E.M. and Chen, W.
Nature Communications 10 (1): 5009. 1 November 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Bosse, J. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J. and Weithauser, A. and Witkowski, M. and Rauch, B.H. and Savvatis, K. and Dörner, A. and Tabaraie, T. and Kasner, M. and Moos, V. and Bösel, D. and Gotthardt, M. and Radke, M.H. and Wegner, M. and Bobbert, P. and Lassner, D. and Tschöpe, C. and Schutheiss, H.P. and Felix, S.B. and Landmesser, U. and Rauch, U.
European Heart Journal 40 (40): 3318-3332. 21 October 2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B. and Hewitt, S.L. and Heltemes-Harris, L.M. and Mandal, M. and Johnson, K. and Rajewsky, K. and Koralov, S.B. and Clark, M.R. and Farrar, M.A. and Skok, J.A.
Nature Communications 10 (1): 4768. 18 October 2019

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C. and Orozco, I.J. and Hoegg-Beiler, M.B. and Soria, A.H. and Hübner, C.A. and Fernandes-Rosa, F.L. and Boulkroun, S. and Zennaro, M.C. and Jentsch, T.J.
Nature Communications 10 (1): 4678. 15 October 2019

A clonal expression biomarker associates with lung cancer mortality.
Biswas, D. and Birkbak, N.J. and Rosenthal, R. and Hiley, C.T. and Lim, E.L. and Papp, K. and Boeing, S. and Krzystanek, M. and Djureinovic, D. and La Fleur, L. and Greco, M. and Döme, B. and Fillinger, J. and Brunnström, H. and Wu, Y. and Moore, D.A. and Skrzypski, M. and Abbosh, C. and Litchfield, K. and Al Bakir, M. and Watkins, T.B.K. and Veeriah, S. and Wilson, G.A. and Jamal-Hanjani, M. and Moldvay, J. and Botling, J. and Chinnaiyan, A.M. and Micke, P. and Hackshaw, A. and Bartek, J. and Csabai, I. and Szallasi, Z. and Herrero, J. and McGranahan, N. and Swanton, C.
Nature Medicine 25 (10): 1540-1548. October 2019

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
Chemi, F. and Rothwell, D.G. and McGranahan, N. and Gulati, S. and Abbosh, C. and Pearce, S.P. and Zhou, C. and Wilson, G.A. and Jamal-Hanjani, M. and Birkbak, N. and Pierce, J. and Kim, C.S. and Ferdous, S. and Burt, D.J. and Slane-Tan, D. and Gomes, F. and Moore, D. and Shah, R. and Al Bakir, M. and Hiley, C. and Veeriah, S. and Summers, Y. and Crosbie, P. and Ward, S. and Mesquita, B. and Dynowski, M. and Biswas, D. and Tugwood, J. and Blackhall, F. and Miller, C. and Hackshaw, A. and Brady, G. and Swanton, C. and Dive, C.
Nature Medicine 25 (10): 1534-1539. October 2019

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Joshi, K. and de Massy, M.R. and Ismail, M. and Reading, J.L. and Uddin, I. and Woolston, A. and Hatipoglu, E. and Oakes, T. and Rosenthal, R. and Peacock, T. and Ronel, T. and Noursadeghi, M. and Turati, V. and Furness, A.J.S. and Georgiou, A. and Wong, Y.N.S. and Ben Aissa, A. and Sunderland, M.W. and Jamal-Hanjani, M. and Veeriah, S. and Birkbak, N.J. and Wilson, G.A. and Hiley, C.T. and Ghorani, E. and Guerra-Assunção, J.A. and Herrero, J. and Enver, T. and Hadrup, S.R. and Hackshaw, A. and Peggs, K.S. and McGranahan, N. and Swanton, C. and Quezada, S.A. and Chain, B.
Nature Medicine 25 (10): 1549-1559. October 2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C. and Berger, H. and Antanaviciute, A. and Vidal, R. and Sauer, S. and Simmons, A. and Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T. and Zhou, X. and Kosla, J. and Adili, A. and Garcia Beccaria, M. and Kotsiliti, E. and Pfister, D. and Johlke, A.L. and Sinha, A. and Sankowski, R. and Schick, M. and Lewis, R. and Dokalis, N. and Seubert, B. and Höchst, B. and Inverso, D. and Heide, D. and Zhang, W. and Weihrich, P. and Manske, K. and Wohlleber, D. and Anton, M. and Hoellein, A. and Seleznik, G. and Bremer, J. and Bleul, S. and Augustin, H.G. and Scherer, F. and Koedel, U. and Weber, A. and Protzer, U. and Förster, R. and Wirth, T. and Aguzzi, A. and Meissner, F. and Prinz, M. and Baumann, B. and Höpken, U.E. and Knolle, P.A. and von Baumgarten, L. and Keller, U. and Heikenwalder, M.
Cancer Cell 36 (3): 250-267. 16 September 2019

Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K. and Imami, K. and Rajewsky, N.
Nature Communications 10 (1): 4205. 16 September 2019

Widespread translational control of fibrosis in the human heart by RNA-binding proteins.
Chothani, S. and Schäfer, S. and Adami, E. and Viswanathan, S. and Widjaja, A.A. and Langley, S.R. and Tan, J. and Wang, M. and Quaife, N.M. and Pua, C.J. and D'Agostino, G. and Shekeran, S.G. and George, B.L. and Lim, S. and Cao, E.Y. and van Heesch, S. and Witte, F. and Felkin, L.E. and Christodoulou, E.G. and Dong, J. and Blachut, S. and Patone, G. and Barton, P.J.R. and Hubner, N. and Cook, S.A. and Rackham, O.J.L.
Circulation 140 (11): 937-951. 10 September 2019

Antibiotics-induced monodominance of a novel gut bacterial order.
Hildebrand, F. and Moitinho-Silva, L. and Blasche, S. and Jahn, M.T.T. and Gossmann, T.I. and Heuerta Cepas, J. and Hercog, R. and Luetge, M. and Bahram, M. and Pryszlak, A. and Alves, R.J. and Waszak, S.M. and Zhu, A. and Ye, L. and Costea, P.I. and Aalvink, S. and Belzer, C. and Forslund, S.K. and Sunagawa, S. and Hentschel, U. and Merten, C. and Patil, K.R. and Benes, V. and Bork, P.
Gut 68 (10): 1781-1790. 9 September 2019

Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
Uroda, T. and Anastasakou, E. and Rossi, A. and Teulon, J.M. and Pellequer, J.L. and Annibale, P. and Pessey, O. and Inga, A. and Chillón, I. and Marcia, M.
Molecular Cell 75 (5): 982-995. 5 September 2019

BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
Hörl, D. and Rojas Rusak, F. and Preusser, F. and Tillberg, P. and Randel, N. and Chhetri, R.K. and Cardona, A. and Keller, P.J. and Harz, H. and Leonhardt, H. and Treier, M. and Preibisch, S.
Nature Methods 16 (9): 870-874. September 2019

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
Legnini, I. and Alles, J. and Karaiskos, N. and Ayoub, S. and Rajewsky, N.
Nature Methods 16 (9): 879-886. September 2019

Maximizing binary interactome mapping with a minimal number of assays.
Choi, S.G. and Olivet, J. and Cassonnet, P. and Vidalain, P.O. and Luck, K. and Lambourne, L. and Spirohn, K. and Lemmens, I. and Dos Santos, M. and Demeret, C. and Jones, L. and Rangarajan, S. and Bian, W. and Coutant, E.P. and Janin, Y.L. and van der Werf, S. and Trepte, P. and Wanker, E.E. and De Las Rivas, J. and Tavernier, J. and Twizere, J.C. and Hao, T. and Hill, D.E. and Vidal, M. and Calderwood, M.A. and Jacob, Y.
Nature Communications 10 (1): 3907. 29 August 2019

Postnatal Tshz3 deletion drives altered corticostriatal function and autism spectrum disorder-like behavior.
Chabbert, D. and Caubit, X. and Roubertoux, P.L. and Carlier, M. and Habermann, B. and Jacq, B. and Salin, P. and Metwaly, M. and Frahm, C. and Fatmi, A. and Garratt, A.N. and Severac, D. and Dubois, E. and Kerkerian-Le Goff, L. and Fasano, L. and Gubellini, P.
Biological Psychiatry 86 (4): 274-285. 15 August 2019

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J. and Termglinchan, V. and Diecke, S. and Itzhaki, I. and Lam, C.K. and Garg, P. and Lau, E. and Greenhaw, M. and Seeger, T. and Wu, H. and Zhang, J.Z and Chen, X. and Gil, I.P. and Ameen, M. and Sallam, K. and Rhee, J.W. and Churko, J.M. and Chaudhary, R. and Chour, T. and Wang, P.J. and Snyder, M.P. and Chang, H.Y. and Karakikes, I. and Wu, J.C.
Nature 572 (7769): 335-340. 15 August 2019

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Chen, H. and Moreno-Moral, A. and Pesce, F. and Devapragash, N. and Mancini, M. and Heng, E.L. and Rotival, M. and Srivastava, P.K. and Harmston, N. and Shkura, K. and Rackham, O.J.L. and Yu, W.P. and Sun, X.M. and Tee, N.G.Z. and Tan, E.L.S. and Barton, P.J.R. and Felkin, L.E. and Lara-Pezzi, E. and Angelini, G. and Beltrami, C. and Pravenec, M. and Schafer, A. and Bottolo, L. and Hubner, N. and Emanueli, C. and Cook, S.A. and Petretto, E.
Nature Communications 10 (1): 3616. 9 August 2019

Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
Lupberger, J. and Croonenborghs, T. and Roca Suarez, A.A. and Van Renne, N. and Jühling, F. and Oudot, M.A. and Virzì, A. and Bandiera, S. and Jamey, C. and Meszaros, G. and Brumaru, D. and Mukherji, A. and Durand, S.C. and Heydmann, L. and Verrier, E.R. and El Saghire, H. and Hamdane, N. and Bartenschlager, R. and Fereshetian, S. and Ramberger, E. and Sinha, R. and Nabian, M. and Everaert, C. and Jovanovic, M. and Mertins, P. and Carr, S.A. and Chayama, K. and Dali-Youcef, N. and Ricci, R. and Bardeesy, N.M. and Fujiwara, N. and Gevaert, O. and Zeisel, M.B. and Hoshida, Y. and Pochet, N. and Baumert, T.F.
Gastroenterology 157 (2): 537-551. August 2019

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Faelber, K. and Dietrich, L. and Noel, J.K. and Wollweber, F. and Pfitzner, A.K. and Mühleip, A. and Sánchez, R. and Kudryashev, M. and Chiaruttini, N. and Lilie, H. and Schlegel, J. and Rosenbaum, E. and Hessenberger, M. and Matthaeus, C. and Kunz, S. and von der Malsburg, A. and Noé, F. and Roux, A. and van der Laan, M. and Kühlbrandt, W. and Daumke, O.
Nature 571 (7765): 429-433. 18 July 2019

Genetics of intellectual disability in consanguineous families.
Hu, H. and Kahrizi, K. and Musante, L. and Fattahi, Z. and Herwig, R. and Hosseini, M. and Oppitz, C. and Abedini, S.S. and Suckow, V. and Larti, F. and Beheshtian, M. and Lipkowitz, B. and Akhtarkhavari, T. and Mehvari, S. and Otto, S. and Mohseni, M. and Arzhangi, S. and Jamali, P. and Mojahedi, F. and Taghdiri, M. and Papari, E. and Soltani Banavandi, M.J. and Akbari, S. and Tonekaboni, S.H. and Dehghani, H. and Ebrahimpour, M.R. and Bader, I. and Davarnia, B. and Cohen, M. and Khodaei, H. and Albrecht, B. and Azimi, S. and Zirn, B. and Bastami, M. and Wieczorek, D. and Bahrami, G. and Keleman, K. and Vahid, L.N. and Tzschach, A. and Gärtner, J. and Gillessen-Kaesbach, G. and Varaghchi, J.R. and Timmermann, B. and Pourfatemi, F. and Jankhah, A. and Chen, W. and Nikuei, P. and Kalscheuer, V.M. and Oladnabi, M. and Wienker, T.F. and Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 24 (7): 1027-1039. July 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M. and Del Mar Reinés, M. and Müllerke, S. and Fischer, C. and Kapalczynska, M. and Berger, H. and Bakker, E.R.M. and Mollenkopf, H.J. and Rothenberg, M.E. and Wiedenmann, B. and Sauer, S. and Meyer, T.F.
Nature Cell Biology 21 (7): 812-823. July 2019

The translational landscape of the human heart.
van Heesch, S. and Witte, F. and Schneider-Lunitz, V. and Schulz, J.F. and Adami, E. and Faber, A. and Kirchner, M. and Maatz, H. and Blachut, S. and Sandmann, C.L. and Kanda, M. and Worth, C.L. and Schafer, S. and Calviello, L. and Merriott, R. and Patone, G. and Hummel, O. and Wyler, E. and Obermayer, B. and Mücke, M. and Lindberg, E.L. and Trnka, F. and Memczak, S. and Schilling, M. and Felkin, L.E. and Barton, P.J.R. and Quaife, N.M. and Vanezis, K. and Diecke, S. and Mukai, M. and Mah, N. and Oh, S.J. and Kurtz, A. and Schramm, C. and Schwinge, D. and Sebode, M. and Harakalova, M. and Asselbergs, F.W. and Vink, A. and de Weger, R.A. and Viswanathan, S. and Widjaja, A.A. and Gärtner-Rommel, A. and Milting, H. and Dos Remedios, C. and Knosalla, C. and Mertins, P. and Landthaler, M. and Vingron, M. and Linke, W.A. and Seidman, J.G. and Seidman, C.E. and Rajewsky, N. and Ohler, U. and Cook, S.A. and Hubner, N.
Cell 178 (1): 242-260. 27 June 2019

HOT or not: examining the basis of high-occupancy target regions.
Wreczycka, K. and Franke, V. and Uyar, B. and Wurmus, R. and Bulut, S. and Tursun, B. and Akalin, A.
Nucleic Acids Research : gkz460. 20 June 2019

Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling, S.A. and Fiedler, P. and Lechner, M. and Pollithy, A. and Ehrenberg, S. and Schiefer, A.I. and Kenner, L. and Feuchtinger, A. and Kühn, R. and Swinerd, G. and Schmidt-Supprian, M. and Strobl, L.J. and Zimber-Strobl, U.
Blood 133 (24): 2597-2609. 13 June 2019

Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
Tito, R.Y. and Chaffron, S. and Caenepeel, C. and Lima-Mendez, G. and Wang, J. and Vieira-Silva, S. and Falony, G. and Hildebrand, F. and Darzi, Y. and Rymenans, L. and Verspecht, C. and Bork, P. and Vermeire, S. and Joossens, M. and Raes, J.
Gut 68 (7): 1180-1189. 7 June 2019

Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints.
Massip, F. and Laurent, M. and Brossas, C. and Fernández-Justel, J.M. and Gómez, M. and Prioleau, M.N. and Duret, L. and Picard, F.
Nucleic Acids Research 47 (10): 5114-5125. 4 June 2019

NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language.
Coelho, L.P. and Alves, R. and Monteiro, P. and Huerta-Cepas, J. and Freitas, A.T. and Bork, P.
Microbiome 7 (1): 84. 3 June 2019

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Dellino, G.I. and Palluzzi, F. and Chiariello, A.M. and Piccioni, R. and Bianco, S. and Furia, L. and De Conti, G. and Bouwman, B.A.M. and Melloni, G. and Guido, D. and Giacò, L. and Luzi, L. and Cittaro, D. and Faretta, M. and Nicodemi, M. and Crosetto, N. and Pelicci, P.G.
Nature Genetics 51 (6): 1011-1023. June 2019

Rapid molecular evolution of pain insensitivity in multiple African rodents.
Eigenbrod, O. and Debus, K.Y. and Reznick, J. and Bennett, N.C. and Sánchez-Carranza, O. and Omerbašić, D. and Hart, D.W. and Barker, A.J. and Zhong, W. and Lutermann, H. and Katandukila, J.V. and Mgode, G. and Park, T.J. and Lewin, G.R.
Science 364 (6443): 852-859. 31 May 2019

Disentangling genetic and environmental effects on the proteotypes of individuals.
Romanov, N. and Kuhn, M. and Aebersold, R. and Ori, A. and Beck, M. and Bork, P.
Cell 177 (5): 1308-1318. 16 May 2019

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities.
Vasaikar, S. and Huang, C. and Wang, X. and Petyuk, V.A. and Savage, S.R. and Wen, B. and Dou, Y. and Zhang, Y. and Shi, Z. and Arshad, O.A. and Gritsenko, M.A. and Zimmerman, L.J. and McDermott, J.E. and Clauss, T.R. and Moore, R.J. and Zhao, R. and Monroe, M.E. and Wang, Y.T. and Chambers, M.C. and Slebos, R.J.C. and Lau, K.S. and Mo, Q. and Ding, L. and Ellis, M. and Thiagarajan, M. and Kinsinger, C.R. and Rodriguez, H. and Smith, R.D. and Rodland, K.D. and Liebler, D.C. and Liu, T. and Zhang, B.
Cell 177 (4): 1035-1049. 2 May 2019

Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
Wei, X. and Zhang, L. and Zhou, Z. and Kwon, O.J. and Zhang, Y. and Nguyen, H. and Dumpit, R. and True, L. and Nelson, P. and Dong, B. and Xue, W. and Birchmeier, W. and Taketo, M.M. and Xu, F. and Creighton, C.J. and Ittmann, M.M. and Xin, L.
Cell Stem Cell 24 (5): 753-768. 2 May 2019

Association between physical activity and risk of hepatobiliary cancers: a multinational cohort study.
Baumeister, S.E. and Schlesinger, S. and Aleksandrova, K. and Jochem, C. and Jenab, M. and Gunter, M.J. and Overvad, K. and Tjønneland, A. and Boutron-Ruault, M.C. and Carbonnel, F. and Fournier, A. and Kühn, T. and Kaaks, R. and Pischon, T. and Boeing, H. and Trichopoulou, A. and Bamia, C. and La Vecchia, C. and Masala, G. and Panico, S. and Fasanelli, F. and Tumino, R. and Grioni, S. and de Mesquita, B.B. and Vermeulen, R. and May, A.M. and Borch, K.B. and Oyeyemi, S.O. and Ardanaz, E. and Rodríguez-Barranco, M. and López, M.D.C. and Felez-Nobrega, M. and Sonestedt, E. and Ohlsson, B. and Hemmingsson, O. and Werner, M. and Perez-Cornago, A. and Ferrari, P. and Stepien, M. and Freisling, H. and Tsilidis, K.K. and Ward, H. and Riboli, E. and Weiderpass, E. and Leitzmann, M.F.
Journal of Hepatology 70 (5): 885-892. May 2019

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer, J. and Walter, C. and Tönges, A. and Aleth, H. and Costa Jordão, M.J. and Leddin, M. and Gröning, V. and Erdmann, T. and Lenz, G. and Roth, J. and Vogl, T. and Prinz, M. and Dugas, M. and Jacobsen, I.D. and Rosenbauer, F.
Nature Immunology 20 (5): 546-558. May 2019

FIP200 claw domain binding to p62 promotes autophagosome formation at ubiquitin condensates.
Turco, E. and Witt, M. and Abert, C. and Bock-Bierbaum, T. and Su, M.Y. and Trapannone, R. and Sztacho, M. and Danieli, A. and Shi, X. and Zaffagnini, G. and Gamper, A. and Schuschnig, M. and Fracchiolla, D. and Bernklau, D. and Romanov, J. and Hartl, M. and Hurley, J.H. and Daumke, O. and Martens, S.
Molecular Cell 74 (2): 330-346. 18 April 2019

SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes.
Toepfer, C.N. and Sharma, A. and Cicconet, M. and Garfinkel, A.C. and Mücke, M. and Neyazi, M. and Willcox, J.A.L. and Agarwal, R. and Schmid, M. and Rao, J. and Ewoldt, J. and Pourquié, O. and Chopra, A. and Chen, C.S. and Seidman, J.G. and Seidman, C.E.
Circulation Research 124 (8): 1172-1183. 12 April 2019

Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Radke, M.H. and Polack, C. and Methawasin, M. and Fink, C. and Granzier, H.L. and Gotthardt, M.
Circulation 139 (15): 1813-1827. 9 April 2019

Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H. and Lebedeva, S. and Hirsekorn, A. and Wurmus, R. and Akalin, A. and Mukherjee, N. and Ohler, U.
Nature Communications 10 (1): 1626. 9 April 2019

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
Thomas, A.M. and Manghi, P. and Asnicar, F. and Pasolli, E. and Armanini, F. and Zolfo, M. and Beghini, F. and Manara, S. and Karcher, N. and Pozzi, C. and Gandini, S. and Serrano, D. and Tarallo, S. and Francavilla, A. and Gallo, G. and Trompetto, M. and Ferrero, G. and Mizutani, S. and Shiroma, H. and Shiba, S. and Shibata, T. and Yachida, S. and Yamada, T. and Wirbel, J. and Schrotz-King, P. and Ulrich, C.M. and Brenner, H. and Arumugam, M. and Bork, P. and Zeller, G. and Cordero, F. and Dias-Neto, E. and Setubal, J.C. and Tett, A. and Pardini, B. and Rescigno, M. and Waldron, L. and Naccarati, A. and Segata, N.
Nature Medicine 25 (4): 667-678. April 2019

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Wirbel, J. and Pyl, P.T. and Kartal, E. and Zych, K. and Kashani, A. and Milanese, A. and Fleck, J.S. and Voigt, A.Y. and Palleja, A. and Ponnudurai, R. and Sunagawa, S. and Coelho, L.P. and Schrotz-King, P. and Vogtmann, E. and Habermann, N. and Niméus, E. and Thomas, A.M. and Manghi, P. and Gandini, S. and Serrano, D. and Mizutani, S. and Shiroma, H. and Shiba, S. and Shibata, T. and Yachida, S. and Yamada, T. and Waldron, L. and Naccarati, A. and Segata, N. and Sinha, R. and Ulrich, C.M. and Brenner, H. and Arumugam, M. and Bork, P. and Zeller, G.
Nature Medicine 25 (4): 679-689. April 2019

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C. and Miah, S.M.S. and Rota, G. and Fonta, N.P. and Wang, H. and Held, W. and Birchmeier, W. and Sexl, V. and Yang, W. and Vivier, E. and Ho, P.C. and Brossay, L. and Guarda, G.
Nature Communications 10 (1): 1444. 29 March 2019

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly, L.A. and Thompson, R.E. and Zhao, S. and Lepack, A.E. and Lyu, Y. and Bhanu, N.V. and Zhang, B. and Loh, Y.H.E. and Ramakrishnan, A. and Vadodaria, K.C. and Heard, K.J. and Erikson, G. and Nakadai, T. and Bastle, R.M. and Lukasak, B.J. and Zebroski, H. and Alenina, N. and Bader, M. and Berton, O. and Roeder, R.G. and Molina, H. and Gage, F.H. and Shen, L. and Garcia, B.A. and Li, H. and Muir, T.W. and Maze, I.
Nature 567 (7749): 535-539. 28 March 2019

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L. and Kärgel, E. and Franke, V. and McShane, E. and Schulz-Beiss, K.W. and Patone, G. and Schleussner, N. and Kolesnichenko, M. and Hübner, N. and Daumke, O. and Selbach, M. and Akalin, A. and Mathas, S. and Scheidereit, C.
Blood 133 (13): 1489-1494. 28 March 2019

PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.
Wolf, F.A. and Hamey, F.K. and Plass, M. and Solana, J. and Dahlin, J.S. and Göttgens, B. and Rajewsky, N. and Simon, L. and Theis, F.J.
Genome Biology 20 (1): 59. 19 March 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C. and Rom, A. and Franke, V. and Imami, K. and Arrey, G. and Terne, M. and Woehler, A. and Akalin, A. and Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H. and Balogh, A. and Yakoub, M. and Homann, S. and Markó, L. and Höges, S. and Tsvetkov, D. and Krannich, A. and Wundersitz, S. and Avery, E.G. and Haase, N. and Kräker, K. and Hering, L. and Maase, M. and Kusche-Vihrog, K. and Grandoch, M. and Fielitz, J. and Kempa, S. and Gollasch, M. and Zhumadilov, Z. and Kozhakhmetov, S. and Kushugulova, A. and Eckardt, K.U. and Dechend, R. and Rump, L.C. and Forslund, S.K. and Müller, D.N. and Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

R-loops enhance polycomb repression at a subset of developmental regulator genes.
Skourti-Stathaki, K. and Torlai Triglia, E. and Warburton, M. and Voigt, P. and Bird, A. and Pombo, A.
Molecular Cell 73 (5): 930-945. 7 March 2019

Microbial abundance, activity and population genomic profiling with mOTUs2.
Milanese, A. and Mende, D.R. and Paoli, L. and Salazar, G. and Ruscheweyh, H.J. and Cuenca, M. and Hingamp, P. and Alves, R. and Costea, P.I. and Coelho, L.P. and Schmidt, T.S.B. and Almeida, A. and Mitchell, A.L. and Finn, R.D. and Huerta-Cepas, J. and Bork, P. and Zeller, G. and Sunagawa, S.
Nature Communications 10 (1): 1014. 4 March 2019

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C. and Vieira-Vieira, C.H. and Hick, T. and Wessels, H.H. and Figini, D. and Moschall, R. and Medenbach, J. and Ohler, U. and Granneman, S. and Selbach, M. and Beckmann, B.M.
Nature Communications 10 (1): 990. 1 March 2019

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
Karabacak Calviello, A. and Hirsekorn, A. and Wurmus, R. and Yusuf, D. and Ohler, U.
Genome Biology 20 (1): 42. 21 February 2019

BCR-dependent lineage plasticity in mature B cells.
Graf, R. and Seagal, J. and Otipoby, K.L. and Lam, K.P. and Ayoub, S. and Zhang, B. and Sander, S. and Chu, V.T. and Rajewsky, K.
Science 363 (6428): 748-753. 15 February 2019

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A. and Alt, S. and Ferreira, R.M.M. and Gribben, C. and Wang, V.M.Y. and Cotoi, C.G. and Salbreux, G. and Behrens, A.
Nature 566 (7742): 126-130. 7 February 2019

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H. and Georgakopoulou, A. and Psatha, N. and Li, C. and Capsali, C. and Samal, H.B. and Anagnostopoulos, A. and Ehrhardt, A. and Izsvák, Z. and Papayannopoulou, T. and Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129 (2): 598-615. 1 February 2019

Eleven loci with new reproducible genetic associations with allergic disease risk.
Ferreira, M.A. and Vonk, J.M. and Baurecht, H. and Marenholz, I. and Tian, C. and Hoffman, J.D. and Helmer, Q. and Tillander, A. and Ullemar, V. and Lu, Y. and Rüschendorf, F. and Hinds, D.A. and Hübner, N. and Weidinger, S. and Magnusson, P.K. and Jorgenson, E. and Lee, Y.A. and Boomsma, D.I. and Karlsson, R. and Almqvist, C. and Koppelman, G.H. and Paternoster, L.
Journal of Allergy and Clinical Immunology 143 (2): 691-699. February 2019

Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N. and Wessels, H.H. and Lebedeva, S. and Sajek, M. and Ghanbari, M. and Garzia, A. and Munteanu, A. and Yusuf, D. and Farazi, T. and Hoell, J.I. and Akat, K.M. and Akalin, A. and Tuschl, T. and Ohler, U.
Nucleic Acids Research 47 (2): 570-581. 25 January 2019

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
Horwitz, S. and O'Connor, O.A. and Pro, B. and Illidge, T. and Fanale, M. and Advani, R. and Bartlett, N.L. and Christensen, J.H. and Morschhauser, F. and Domingo-Domenech, E. and Rossi, G. and Kim, W.S. and Feldman, T. and Lennard, A. and Belada, D. and Illés, A. and Tobinai, K. and Tsukasaki, K. and Yeh, S.P. and Shustov, A. and Hüttmann, A. and Savage, K.J. and Yuen, S. and Iyer, S. and Zinzani, P.L. and Hua, Z. and Little, M. and Rao, S. and Woolery, J. and Manley, T. and Trümper, L.
Lancet 393 (10168): 229-240. 19 January 2019

E47 modulates hepatic glucocorticoid action.
Hemmer, M.C. and Wierer, M. and Schachtrup, K. and Downes, M. and Hübner, N. and Evans, R.M. and Uhlenhaut, N.H.
Nature Communications 10 (1): 306. 18 January 2019

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C. and Campo Garcia, J. and Woelfle, T. and Romero-Suarez, S. and Olah, M. and Watanabe, F. and Cao, L. and Yeste, A. and Tukker, J.J. and Quintana, F.J. and Imitola, J. and Witzel, F. and Schmitz, D. and Morkel, M. and Paul, F. and Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10 (1): 217. 15 January 2019

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
James, A.R. and Schroeder, M.P. and Neumann, M. and Bastian, L. and Eckert, C. and Gökbuget, N. and Tanchez, J.O. and Schlee, C. and Isaakidis, K. and Schwartz, S. and Burmeister, T. and von Stackelberg, A. and Rieger, M.A. and Göllner, S. and Horstman, M. and Schrappe, M. and Kirschner-Schwabe, R. and Brüggemann, M. and Müller-Tidow, C. and Serve, H. and Akalin, A. and Baldus, C.D.
Journal of Hematology & Oncology 12 (1): 8. 14 January 2019

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Huerta-Cepas, J. and Szklarczyk, D. and Heller, D. and Hernández-Plaza, A. and Forslund, S.K. and Cook, H. and Mende, D.R. and Letunic, I. and Rattei, T. and Jensen, L.J. and von Mering, C. and Bork, P.
Nucleic Acids Research 47 (D1): D309-D314. 8 January 2019

STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
Szklarczyk, D. and Gable, A.L. and Lyon, D. and Junge, A. and Wyder, S. and Huerta-Cepas, J. and Simonovic, M. and Doncheva, N.T. and Morris, J.H. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 47 (D1): D607-D613. 8 January 2019

Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L. and Chen, X. and Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
Hernáez, B. and Alonso-Lobo, J.M. and Montanuy, I. and Fischer, C. and Sauer, S. and Sigal, L. and Sevilla, N. and Alcamí, A.
Nature Communications 9 (1): 5440. 21 December 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
Kabrani, E. and Chu, V.T. and Tasouri, E. and Sommermann, T. and Baßler, K. and Ulas, T. and Zenz, T. and Bullinger, L. and Schultze, J.L. and Rajewsky, K. and Sander, S.
Blood 132 (25): 2670-2683. 20 December 2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N. and Kolesnichenko, M. and Beaudette, P. and Popp, O. and Uyar, B. and Sun, W. and Tufan, A.B. and Perder, B. and Akalin, A. and Chen, W. and Mertins, P. and Dittmar, G. and Hinz, M. and Scheidereit, C.
EMBO Journal 37 (24): e98658. 14 December 2018

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C. and Silva, R.L. and Margaria, J.P. and Pirali, T. and Mattos, M.S. and Kraemer, L.R. and Reis, D.C. and Grosa, G. and Copperi, F. and Dalmarco, E.M. and Lima-Júnior, R.C.P. and Aprile, S. and Sala, V. and Dal Bello, F. and Prado, D.S. and Alves-Filho, J.C. and Medana, C. and Cassali, G.D. and Tron, G.C. and Teixeira, M.M. and Ciraolo, E. and Russo, R.C. and Hirsch, E.
Nature Communications 9 (1): 5232. 12 December 2018

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.
Cabral-Marques, O. and Marques, A. and Giil, L.M. and De Vito, R. and Rademacher, J. and Günther, J. and Lange, T. and Humrich, J.Y. and Klapa, S. and Schinke, S. and Schimke, L.F. and Marschner, G. and Pitann, S. and Adler, S. and Dechend, R. and Müller, D.N. and Braicu, I. and Sehouli, J. and Schulze-Forster, K. and Trippel, T. and Scheibenbogen, C. and Staff, A. and Mertens, P.R. and Löbel, M. and Mastroianni, J. and Plattfaut, C. and Gieseler, F. and Dragun, D. and Engelhardt, B.E. and Fernandez-Cabezudo, M.J. and Ochs, H.D. and Al-Ramadi, B.K. and Lamprecht, P. and Mueller, A. and Heidecke, H. and Riemekasten, G.
Nature Communications 9 (1): 5224. 6 December 2018

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Serresi, M. and Siteur, B. and Hulsman, D. and Company, C. and Schmitt, M.J. and Lieftink, C. and Morris, B. and Cesaroni, M. and Proost, N. and Beijersbergen, R.L. and van Lohuizen, M. and Gargiulo, G.
Journal of Experimental Medicine 215 (12): 3115. 3 December 2018

A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links.
Pedersen, H.K. and Forslund, S.K. and Gudmundsdottir, V. and Petersen, A.Ø. and Hildebrand, F. and Hyötyläinen, T. and Nielsen, T. and Hansen, T. and Bork, P. and Ehrlich, S.D. and Brunak, S. and Oresic, M. and Pedersen, O. and Nielsen, H.B.
Nature Protocols 13 (12): 2781-2800. December 2018

Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.
Vladimirov, N. and Wang, C. and Höckendorf, B. and Pujala, A. and Tanimoto, M. and Mu, Y. and Yang, C.T. and Wittenbach, J.D. and Freeman, J. and Preibisch, S. and Koyama, M. and Keller, P.J. and Ahrens, M.B.
Nature Methods 15 (12): 1117-1125. December 2018

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
Escot, S. and Willnow, D. and Naumann, H. and Di Francescantonio, S. and Spagnoli, F.M.
Nature Communications 9 (1): 5082. 30 November 2018

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Angulo-Urarte, A. and Casado, P. and Castillo, S.D. and Kobialka, P. and Kotini, M.P. and Figueiredo, A.M. and Castel, P. and Rajeeve, V. and Milà-Guasch, M. and Millan, J. and Wiesner, C. and Serra, H. and Muixi, L. and Casanovas, O. and Viñals, F. and Affolter, M. and Gerhardt, H. and Huveneers, S. and Belting, H.G. and Cutillas, P.R. and Graupera, M.
Nature Communications 9 (1): 4826. 16 November 2018

The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
Delgado-Benito, V. and Rosen, D.B. and Wang, Q. and Gazumyan, A. and Pai, J.A. and Oliveira, T.Y. and Sundaravinayagam, D. and Zhang, W. and Andreani, M. and Keller, L. and Kieffer-Kwon, K.R. and Pękowska, A. and Jung, S. and Driesner, M. and Subbotin, R.I. and Casellas, R. and Chait, B.T. and Nussenzweig, M.C. and Di Virgilio, M.
Molecular Cell 72 (4): 636-649. 15 November 2018

Potassium channel-based optogenetic silencing.
Bernal Sierra, Y.A. and Rost, B.R. and Pofahl, M. and Fernandes, A.M. and Kopton, R.A. and Moser, S. and Holtkamp, D. and Masala, N. and Beed, P. and Tukker, J.J. and Oldani, S. and Bönigk, W. and Kohl, P. and Baier, H. and Schneider-Warme, F. and Hegemann, P. and Beck, H. and Seifert, R. and Schmitz, D.
Nature Communications 9 (1): 4611. 5 November 2018

omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data.
Drewe-Boss, P. and Wessels, H.H. and Ohler, U.
Genome Biology 19 : 183. 1 November 2018

Nervous system regionalization entails axial allocation before neural differentiation.
Metzis, V. and Steinhauser, S. and Pakanavicius, E. and Gouti, M. and Stamataki, D. and Ivanovitch, K. and Watson, T. and Rayon, T. and Mousavy Gharavy, S.N. and Lovell-Badge, R. and Luscombe, N.M. and Briscoe, J.
Cell 175 (4): 1105-1118. 1 November 2018

Recovery of gut microbiota of healthy adults following antibiotic exposure.
Palleja, A. and Mikkelsen, K.H. and Forslund, S.K. and Kashani, A. and Allin, K.H. and Nielsen, T. and Hansen, T.H. and Liang, S. and Feng, Q. and Zhang, C. and Pyl, P.T. and Coelho, L.P. and Yang, H. and Wang, J. and Typas, A. and Nielsen, M.F. and Nielsen, H.B. and Bork, P. and Wang, J. and Vilsbøll, T. and Hansen, T. and Knop, F.K. and Arumugam, M. and Pedersen, O.
Nature Microbiology 3 : 1255-1265. November 2018

Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M. and Karabacak, A. and Glahs, A. and Kolundzic, E. and Hirsekorn, A. and Carda, A. and Tursun, B. and Zinzen, R.P. and Lacadie, S.A. and Ohler, U.
Nature Communications 9 (1): 4472. 26 October 2018

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B. and Nagy, G. and Czimmerer, Z. and Horvath, A. and Hammers, D.W. and Cuaranta-Monroy, I. and Poliska, S. and Tzerpos, P. and Kolostyak, Z. and Hays, T.T. and Patsalos, A. and Houtman, R. and Sauer, S. and Francois-Deleuze, J. and Rastinejad, F. and Balint, B.L. and Sweeney, H.L. and Nagy, L.
Immunity 49 (4): 615-626. 16 October 2018

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E. and Loud, M.C. and Daou, I. and Marshall, K.L. and Schwaller, F. and Kühnemund, J. and Francisco, A.G. and Keenan, W.T. and Dubin, A.E. and Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K. and Milek, M. and Bogdanow, B. and Yasuda, T. and Kastelic, N. and Zauber, H. and Ishihama, Y. and Landthaler, M. and Selbach, M.
Molecular Cell 72 (1): 84-98. 4 October 2018

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
Kragesteen, B.K. and Spielmann, M. and Paliou, C. and Heinrich, V. and Schöpflin, R. and Esposito, A. and Annunziatella, C. and Bianco, S. and Chiariello, A.M. and Jerković, I. and Harabula, I. and Guckelberger, P. and Pechstein, M. and Wittler, L. and Chan, Wi.L. and Franke, M. and Lupiáñez, D.G. and Kraft, K. and Timmermann, B. and Vingron, M. and Visel, A. and Nicodemi, M. and Mundlos, S. and Andrey, G.
Nature Genetics 50 (10): 1463-1473. October 2018

Challenges and guidelines toward 4D nucleome data and model standards.
Marti-Renom, M.A. and Almouzni, G. and Bickmore, W.A. and Bystricky, K. and Cavalli, G. and Fraser, P. and Gasser, S.M. and Giorgetti, L. and Heard, E. and Nicodemi, M. and Nollmann, M. and Orozco, M. and Pombo, A. and Torres-Padilla, M.E.
Nature Genetics 50 (10): 1352-1358. October 2018

Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K. and Vogt, L. and Greber, B. and Diecke, S. and Boccaccini, A.R. and Scheibel, T. and Engel, F.B.
Advanced Functional Materials 28 (42): 1803951. October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn, J.D. and Miller, P.G. and Silver, A.J. and Sellar, R.S. and Bhatt, S. and Gibson, C. and McConkey, M. and Adams, D. and Mar, B. and Mertins, P. and Fereshetian, S. and Krug, K. and Zhu, H. and Letai, A. and Carr, S.A. and Doench, J. and Jaiswal, S. and Ebert, B.L.
Blood 132 (11): 1095-1105. 13 September 2018

mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A. and Buntru, A. and Schindler, F. and Hasenkopf, R. and Schulz, A. and Brusendorf, L. and Klockmeier, K. and Grelle, G. and McMahon, B. and Niederlechner, H. and Jansen, I. and Diez, L. and Edel, J. and Boeddrich, A. and Franklin, S.A. and Baldo, B. and Schnoegl, S. and Kunz, S. and Purfürst, B. and Gaertner, A. and Kampinga, H.H. and Morton, A.J. and Petersén, Å. and Kirstein, J. and Bates, G.P. and Wanker, E.E.
Molecular Cell 71 (5): 675-688. 6 September 2018

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T. and Braud, S. and Jüttner, R. and Voigt, B.C. and Paulick, K. and Sheean, M.E. and Klisch, C. and Gueneykaya, D. and Rathjen, F.G. and Geiger, J.R.P. and Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37 (17): e98858. 3 September 2018

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D. and Schön, C. and Loddenkemper, C. and Lohneis, P. and Kühl, A.A. and Sommermann, T. and Blankenstein, T. and Willimsky, G.
Blood 132 (9): 924-934. 30 August 2018

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S. and Gohlke, U. and Broeker, N.K. and Roske, Y. and Heinemann, U. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140 (33): 10447-10455. 22 August 2018

Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J. and Noel, J.K. and Low, H.H.
Nature Communications 9 (1): 3345. 21 August 2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A. and Huang, J. and Györfi, A.H. and Matei, A.E. and Trinh-Minh, T. and Xu, X. and Li, Y.N. and Chen, C.W. and Lin, J. and Dees, C. and Beyer, C. and Gelse, K. and Zhang, Z.Y. and Bergmann, C. and Ramming, A. and Birchmeier, W. and Distler, O. and Schett, G. and Distler, J.H.W.
Nature Communications 9 (1): 3259. 14 August 2018

Structure and function of the global topsoil microbiome.
Bahram, M. and Hildebrand, F. and Forslund, S.K. and Anderson, J.L. and Soudzilovskaia, N.A. and Bodegom, P.M. and Bengtsson-Palme, J. and Anslan, S. and Coelho, L.P. and Harend, H. and Huerta-Cepas, J. and Medema, M.H. and Maltz, M.R. and Mundra, S. and Olsson, P.A. and Pent, M. and Põlme, S. and Sunagawa, S. and Ryberg, M. and Tedersoo, L. and Bork, P.
Nature 560 (7717): 233-237. 9 August 2018

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome.
Maass, P.G. and Weise, A. and Rittscher, K. and Lichtenwald, J. and Barutcu, A.R. and Liehr, T. and Aydin, A. and Wefeld-Neuenfeld, Y. and Pölsler, L. and Tinschert, S. and Rinn, J.L. and Luft, F.C. and Bähring, S.
EMBO Journal 37 (15): e96257. 1 August 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage, J. and Standl, M. and Curtin, J.A. and Jessen, L.E. and Thorsen, J. and Tian, C. and Schoettler, N. and Flores, C. and Abdellaoui, A. and Ahluwalia, T.S. and Alves, A.C. and Amaral, A.F.S. and Antó, J.M. and Arnold, A. and Barreto-Luis, A. and Baurecht, H. and van Beijsterveldt, C.E.M. and Bleecker, E.R. and Bonàs-Guarch, S. and Boomsma, D.I. and Brix, S. and Bunyavanich, S. and Burchard, E.G. and Chen, Z. and Curjuric, I. and Custovic, A. and den Dekker, H.T. and Dharmage, S.C. and Dmitrieva, J. and Duijts, L. and Ege, M.J. and Gauderman, W.J. and Georges, M. and Gieger, C. and Gilliland, F. and Granell, R. and Gui, H. and Hansen, T. and Heinrich, J. and Henderson, J. and Hernandez-Pacheco, N. and Holt, P. and Imboden, M. and Jaddoe, V.W.V. and Jarvelin, M.R. and Jarvis, D.L. and Jensen, K.K. and Jónsdóttir, I. and Kabesch, M. and Kaprio, J. and Kumar, A. and Lee, Y.A. and Levin, A.M. and Li, X. and Lorenzo-Diaz, F. and Melén, E. and Mercader, J.M. and Meyers, D.A. and Myers, R. and Nicolae, D.L. and Nohr, E.A. and Palviainen, T. and Paternoster, L. and Pennell, C.E. and Pershagen, G. and Pino-Yanes, M. and Probst-Hensch, N.M. and Rüschendorf, F. and Simpson, A. and Stefansson, K. and Sunyer, J. and Sveinbjornsson, G. and Thiering, E. and Thompson, P.J. and Torrent, M. and Torrents, D. and Tung, J.Y. and Wang, C.A. and Weidinger, S. and Weiss, S. and Willemsen, G. and Williams, L.K. and Ober, C. and Hinds, D.A. and Ferreira, M.A. and Bisgaard, H. and Strachan, D.P. and Bønnelykke, K.
Nature Genetics 50 (8): 1072-1080. August 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B. and Hermes, R. and Colleoni, S. and Diecke, S. and Holtze, S. and Renfree, M.B. and Stejskal, J. and Hayashi, K. and Drukker, M. and Loi, P. and Göritz, F. and Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L. and Frainay, C. and Chazalviel, M. and Cabanettes, F. and Gloaguen, Y. and Camenen, E. and Merlet, B. and Heux, S. and Portais, J.C. and Poupin, N. and Vinson, F. and Jourdan, F.
Nucleic Acids Research 46 (W1): W495-W502. 2 July 2018

iPath3.0: interactive pathways explorer v3.
Darzi, Y. and Letunic, I. and Bork, P. and Yamada, T.
Nucleic Acids Research 46 (W1): W510-W513. 2 July 2018

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J. and Luong, T.T. and Tuffaha, R. and Musculus, K. and Auer, T. and Lian, X. and Daniel, C. and Zickler, D. and Boehme, B. and Sacherer, M. and Metzler, B. and Kuhl, D. and Gollasch, M. and Amann, K. and Müller, D.N. and Pieske, B. and Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128 (7): 3024-3040. 2 July 2018

Species-specific activity of antibacterial drug combinations.
Brochado, A.R. and Telzerow, A. and Bobonis, J. and Banzhaf, M. and Mateus, A. and Selkrig, J. and Huth, E. and Bassler, S. and Zamarreño Beas, J. and Zietek, M. and Ng, N. and Foerster, S. and Ezraty, B. and Py, B. and Barras, F. and Savitski, M.M. and Bork, P. and Göttig, S. and Typas, A.
Nature 559 (7713): 259-263. July 2018

Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Nature 559 (7713): 211-216. July 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S. and Zhou, J. and Liu, J.B. and Wu, Z. and Xu, X. and Li, T. and Xu, D. and Schumacher, S.E. and Puschhof, J. and McFarland, J. and Zou, C. and Dulak, A. and Henderson, L. and Xu, P. and O'Day, E. and Rendak, R. and Liao, W.L. and Cecchi, F. and Hembrough, T. and Schwartz, S. and Szeto, C. and Rustgi, A.K. and Wong, K.K. and Diehl, J.A. and Jensen, K. and Graziano, F. and Ruzzo, A. and Fereshetian, S. and Mertins, P. and Carr, S.A. and Beroukhim, R. and Nakamura, K. and Oki, E. and Watanabe, M. and Baba, H. and Imamura, Y. and Catenacci, D. and Bass, A.J.
Nature Medicine 24 (7): 968-977. July 2018

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M. and Swinarski, M. and Meyer, A.M. and Müller, N.V. and Özcan, I. and Donat, S. and Burger, A. and Gilbert, S. and Mosimann, C. and Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

Pervasive protein thermal stability variation during the cell cycle.
Becher, I. and Andrés-Pons, A. and Romanov, N. and Stein, F. and Schramm, M. and Baudin, F. and Helm, D. and Kurzawa, N. and Mateus, A. and Mackmull, M.T. and Typas, A. and Müller, C.W. and Bork, P. and Beck, M. and Savitski, M.M.
Cell 173 (6): 1495-1507. 31 May 2018

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M. and Solana, J. and Wolf, F.A. and Ayoub, S. and Misios, A. and Glažar, P. and Obermayer, B. and Theis, F.J. and Kocks, C. and Rajewsky, N.
Science 360 (6391): eaaq1723. 25 May 2018

Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y. and Sabag, O. and Skversky, Y. and Spiro, A. and Steinberg, B. and Bernstein, D. and Wang, A. and Kieckhaefer, J. and Li, C. and Pikarsky, E. and Levin-Klein, R. and Goren, A. and Rajewsky, K. and Kaestner, K.H. and Cedar, H.
Nature Communications 9 (1): 2040. 23 May 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A. and Prummel, K.D. and Merks, A.M. and Mickoleit, M. and Brombacher, E.C. and Huisken, J. and Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B. and Nagy, G. and Horvath, A. and Czimmerer, Z. and Cuaranta-Monroy, I. and Poliska, S. and Hays, T.T. and Sauer, S. and Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46 (9): 4425-4439. 18 May 2018

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T. and Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9 (1): 1974. 17 May 2018

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M. and Gonzalez, E. and Teixeira da Costa, A.R. and Wask, L. and Gravenstein, I. and Pardo, M. and Pietzke, M. and Gurumurthy, R.K. and Angermann, J. and Laudeley, R. and Glage, S. and Meyer, M. and Chumduri, C. and Kempa, S. and Dinkel, K. and Unger, A. and Klebl, B. and Klos, A. and Meyer, T.F.
Cell Host & Microbe 23 (5): 661-671. 9 May 2018

Polymer physics predicts the effects of structural variants on chromatin architecture.
Bianco, S. and Lupiáñez, D.G. and Chiariello, A.M. and Annunziatella, C. and Kraft, K. and Schöpflin, R. and Wittler, L. and Andrey, G. and Vingron, M. and Pombo, A. and Mundlos, S. and Nicodemi, M.
Nature Genetics 50 (5): 662-667. May 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L. and Alvarez-Martinez, M. and Luisier, R. and Cox, L.S. and Sodenkamp, J. and Hosking, C. and Pérez-Mazliah, D. and Whicher, C. and Kannan, Y. and Potempa, K. and Wu, X. and Bhaw, L. and Wende, H. and Sieweke, M.H. and Elgar, G. and Wilson, M. and Briscoe, J. and Metzis, V. and Langhorne, J. and Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars.
Spanjaard, B. and Hu, B. and Mitic, N. and Olivares-Chauvet, P. and Janjuha, S. and Ninov, N. and Junker, J.P.
Nature Biotechnology 36 (5): 469-473. May 2018

Similarity of the dog and human gut microbiomes in gene content and response to diet.
Coelho, L.P. and Kultima, J.R. and Costea, P.I. and Fournier, C. and Pan, Y. and Czarnecki-Maulden, G. and Hayward, M.R. and Forslund, S.K. and Schmidt, T.S.B. and Descombes, P. and Jackson, J.R. and Li, Q. and Bork, P.
Microbiome 6 (1): 72. 19 April 2018

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.
Turajlic, S. and Xu, H. and Litchfield, K. and Rowan, A. and Horswell, S. and Chambers, T. and O'Brien, T. and Lopez, J.I. and Watkins, T.B.K. and Nicol, D. and Stares, M. and Challacombe, B. and Hazell, S. and Chandra, A. and Mitchell, T.J. and Au, L. and Eichler-Jonsson, C. and Jabbar, F. and Soultati, A. and Chowdhury, S. and Rudman, S. and Lynch, J. and Fernando, A. and Stamp, G. and Nye, E. and Stewart, A. and Xing, W. and Smith, J.C. and Escudero, M. and Huffman, A. and Matthews, N. and Elgar, G. and Phillimore, B. and Costa, M. and Begum, S. and Ward, S. and Salm, M. and Boeing, S. and Fisher, R. and Spain, L. and Navas, C. and Grönroos, E. and Hobor, S. and Sharma, S. and Aurangzeb, I. and Lall, S. and Polson, A. and Varia, M. and Horsfield, C. and Fotiadis, N. and Pickering, L. and Schwarz, R.F. and Silva, B. and Herrero, J. and Luscombe, N.M. and Jamal-Hanjani, M. and Rosenthal, R. and Birkbak, N.J. and Wilson, G.A. and Pipek, O. and Ribli, D. and Krzystanek, M. and Csabai, I. and Szallasi, Z. and Gore, M. and McGranahan, N. and Van Loo, P. and Campbell, P. and Larkin, J. and Swanton, C.
Cell 173 (3): 595-610. 19 April 2018

Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo.
Jouhanneau, J.S. and Kremkow, J. and Poulet, J.F.A.
Nature Communications 9 (1): 1540. 18 April 2018

Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G. and Kim, Y. and de Almeida, P.E. and Termglinchan, V. and Diecke, S. and Shao, N.Y. and Wei, T.T. and Yi, H. and Dey, De. and Nelakanti, R. and Brouwer, T.P. and Paik, D.T. and Sagiv-Barfi, I. and Han, A. and Quax, P.H.A. and Hamming, J.F. and Levy, R. and Davis, M.M. and Wu, J.C.
Cell Stem Cell 22 (4): 501-513. 5 April 2018

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y. and Eslami, A. and van Ginkel, C.D. and Akhabir, L. and Wan, M. and Yin, D. and Ellis, G. and Ben-Shoshan, M. and Marenholz, I. and Martino, D. and Ferreira, M.A. and Allen, K. and Mazer, B. and de Groot, H. and de Jong, N.W. and Gerth van Wijk, R. and Dubois, A.E.J. and Grosche, S. and Ashley, S. and Rüschendorf, F. and Kalb, B. and Beyer, K. and Nöthen, M.M. and Lee, Y.A. and Chin, R. and Cheuk, S. and Hoffman, J. and Jorgensen, E. and Witte, J.S. and Melles, R.B. and Hong, X. and Wang, X. and Hui, J. and Musk, A.W.B. and Hunter, M. and James, A.L. and Koppelman, G.H. and Sandford, A.J. and Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141 (4): 1513-1516. April 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.
Tramontano, M. and Andrejev, S. and Pruteanu, M. and Klünemann, M. and Kuhn, M. and Galardini, M. and Jouhten, P. and Zelezniak, A. and Zeller, G. and Bork, P. and Typas, A. and Patil, K.R.
Nature Microbiology 3 (3): 514-522. April 2018

Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier, L. and Pruteanu, M. and Kuhn, M. and Zeller, G. and Telzerow, A. and Anderson, E.E. and Brochado, A.R. and Fernandez, K.C. and Dose, H. and Mori, H. and Patil, K.R. and Bork, P. and Typas, A.
Nature 555 (7698): 623-628. 29 March 2018

SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K. and Kranz, A. and Fohgrub, J. and Jolly, A. and Bledau, A.S. and Di Virgilio, M. and Lesche, M. and Dahl, A. and Höfer, T. and Stewart, A.F. and Waskow, C.
Blood 131 (12): 1311-1324. 22 March 2018

Transposase-DNA complex structures reveal mechanisms for conjugative transposition of antibiotic resistance.
Rubio-Cosials, A. and Schulz, E.C. and Lambertsen, L. and Smyshlyaev, G. and Rojas-Cordova, C. and Forslund, K. and Karaca, E. and Bebel, A. and Bork, P. and Barabas, O.
Cell 173 (1): 208-220. 22 March 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Voltage gating of mechanosensitive PIEZO channels.
Moroni, M. and Servin-Vences, M.R. and Fleischer, R. and Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9 (1): 1096. 15 March 2018

High-throughput identification of RNA nuclear enrichment sequences.
Shukla, C.J. and McCorkindale, A.L. and Gerhardinger, C. and Korthauer, K.D. and Cabili, M.N. and Shechner, D.M. and Irizarry, R.A. and Maass, P. and Rinn, J.L.
EMBO Journal 37 (6): e98452. 15 March 2018

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Fernandes-Rosa, F.L. and Daniil, G. and Orozco, I.J. and Göppner, C. and El Zein, R. and Jain, V. and Boulkroun, S. and Jeunemaitre, X. and Amar, L. and Lefebvre, H. and Schwarzmayr, T. and Strom, T.M. and Jentsch, T.J. and Zennaro, M.C.
Nature Genetics 50 (3): 355-361. March 2018

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Scholl, U.I. and Stölting, G. and Schewe, J. and Thiel, A. and Tan, H. and Nelson-Williams, C. and Vichot, A.A. and Jin, S.C. and Loring, E. and Untiet, V. and Yoo, T. and Choi, J. and Xu, S. and Wu, A. and Kirchner, M. and Mertins, P. and Rump, L.C. and Onder, A.M. and Gamble, C. and McKenney, D. and Lash, R.W. and Jones, D.P. and Chune, G. and Gagliardi, P. and Choi, M. and Gordon, R. and Stowasser, M. and Fahlke, C. and Lifton, R.P.
Nature Genetics 50 (3): 349-354. March 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability.
Dawes, J.M. and Weir, G.A. and Middleton, S.J. and Patel, R. and Chisholm, K.I. and Pettingill, P. and Peck, L.J. and Sheridan, J. and Shakir, A. and Jacobson, L. and Gutierrez-Mecinas, M. and Galino, J. and Walcher, J. and Kühnemund, J. and Kuehn, H. and Sanna, M.D. and Lang, B. and Clark, A.J. and Themistocleous, A.C. and Iwagaki, N. and West, S.J. and Werynska, K. and Carroll, L. and Trendafilova, T. and Menassa, D.A. and Giannoccaro, M.P. and Coutinho, E. and Cervellini, I. and Tewari, D. and Buckley, C. and Leite, M.I. and Wildner, H. and Zeilhofer, H.U. and Peles, E. and Todd, A.J. and McMahon, S.B. and Dickenson, A.H. and Lewin, G.R. and Vincent, A. and Bennett, D.L.
Neuron 97 (4): 806-822. 21 February 2018

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.
Szulzewsky, F. and Schwendinger, N. and Güneykaya, D. and Cimino, P.J. and Hambardzumyan, D. and Synowitz, M. and Holland, E.C. and Kettenmann, H.
Neuro-Oncology 20 (3): 355-366. 19 February 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y. and Schleich, K. and Yue, B. and Ji, S. and Lohneis, P. and Kemper, K. and Silvis, M.S. and Qutob, N. and van Rooijen, E. and Werner-Klein, M. and Li, L. and Dhawan, D. and Meierjohann, S. and Reimann, M. and Elkahloun, A. and Treitschke, S. and Dörken, B. and Speck, C. and Mallette, F.A. and Zon, L.I. and Holmen, S.L. and Peeper, D.S. and Samuels, Y. and Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Precisely timed nicotinic activation drives SST inhibition in neocortical circuits.
Urban-Ciecko, J. and Jouhanneau, J.S. and Myal, S.E. and Poulet, J.F.A. and Barth, A.L.
Neuron 97 (3): 611-625. 7 February 2018

The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
Althof, N. and Goetzke, C.C. and Kespohl, M. and Voss, K. and Heuser, A. and Pinkert, S. and Kaya, Z. and Klingel, K. and Beling, A.
EMBO Molecular Medicine 10 (2): 200-218. 1 February 2018

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer, E.E. and Stuhlmann, T. and Weinert, S. and Haan, E. and Van Esch, H. and Holvoet, M. and Boyle, J. and Leffler, M. and Raynaud, M. and Moraine, C. and van Bokhoven, H. and Kleefstra, T. and Kahrizi, K. and Najmabadi, H. and Ropers, H.H. and Delgado, M.R. and Sirsi, D. and Golla, S. and Sommer, A. and Pietryga, M.P. and Chung, W.K. and Wynn, J. and Rohena, L. and Bernardo, E. and Hamlin, D. and Faux, B.M. and Grange, D.K. and Manwaring, L. and Tolmie, J. and Joss, S. and Cobben, J.M. and Duijkers, F.A.M. and Goehringer, J.M. and Challman, T.D. and Hennig, F. and Fischer, U. and Grimme, A. and Suckow, V. and Musante, L. and Nicholl, J. and Shaw, M. and Lodh, S.P. and Niu, Z. and Rosenfeld, J.A. and Stankiewicz, P. and Jentsch, T.J. and Gecz, J. and Field, M. and Kalscheuer, V.M.
Molecular Psychiatry 23 (2): 222-230. February 2018

A global ocean atlas of eukaryotic genes.
Carradec, Q. and Pelletier, E. and Da Silva, C. and Alberti, A. and Seeleuthner, Y. and Blanc-Mathieu, R. and Lima-Mendez, G. and Rocha, F. and Tirichine, L. and Labadie, K. and Kirilovsky, A. and Bertrand, A. and Engelen, S. and Madoui, M.A. and Méheust, R. and Poulain, J. and Romac, S. and Richter, D.J. and Yoshikawa, G. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Jaillon, O. and Aury, J.M. and Karsenti, E. and Sullivan, M.B. and Sunagawa, S. and Bork, P. and Not, F. and Hingamp, P. and Raes, J. and Guidi, L. and Ogata, H. and De Vargas, C. and Iudicone, D. and Bowler, C. and Wincker, P.
Nature Communications 9 (1): 373. 25 January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A. and Buntru, A. and Arnsburg, K. and Ast, A. and Iburg, M. and Juenemann, K. and Pigazzini, M.L. and Mlody, B. and Puchkov, D. and Priller, J. and Wanker, E.E. and Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z. and Daniel, B. and Horvath, A. and Rückerl, D. and Nagy, G. and Kiss, M. and Peloquin, M. and Budai, M.M. and Cuaranta-Monroy, I. and Simandi, Z. and Steiner, L. and Nagy, B. and Poliska, S. and Banko, C. and Bacso, Z. and Schulman, I.G. and Sauer, S. and Deleuze, J.F. and Allen, J.E. and Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

MVP: a microbe-phage interaction database.
Gao, N.L. and Zhang, C. and Zhang, Z. and Hu, S. and Lercher, M.J. and Zhao, X.M. and Bork, P. and Liu, Z. and Chen, W.H.
Nucleic Acids Research 46 (D1): D700-D707. 4 January 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M. and Klinger, B. and Klünemann, M. and Sieber, A. and Uhlitz, F. and Sauer, S. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F. and Margaritte-Jeannin, P. and Barnes, K.C. and Cookson, W.O.C. and Altmüller, J. and Ang, W. and Barr, R.G. and Beaty, T.H. and Becker, A.B. and Beilby, J. and Bisgaard, H. and Bjornsdottir, U.S. and Bleecker, E. and Bonnelykke, K. and Boomsma, D.I. and Bouzigon, E. and Brightling, C.E. and Brossard, M. and Brusselle, G.G. and Burchard, E. and Burkart, K.M. and Bush, A. and Chan-Yeung, M. and Chung, K.F. and Couto Alves, A. and Curtin, J.A. and Custovic, A. and Daley, D. and de Jongste, J.C. and Del-Rio-Navarro, B.E. and Donohue, K.M. and Duijts, L. and Eng, C. and Eriksson, J.G. and Farrall, M. and Fedorova, Y. and Feenstra, B. and Ferreira, M.A. and Freidin, M.B. and Gajdos, Z. and Gauderman, J. and Gehring, U. and Geller, F. and Genuneit, J. and Gharib, S.A and Gilliland, F. and Granell, R. and Graves, P.E. and Gudbjartsson, D.F. and Haahtela, T. and Heckbert, S.R. and Heederik, D. and Heinrich, J. and Helioevaara, M. and Henderson, J. and Himes, B.E. and Hirose, H. and Hirschhorn, J.N. and Hofman, A. and Holt, P. and Hottenga, J. and Hudson, T.J. and Hui, J. and Imboden, M. and Ivanov, V. and Jaddoe, V.W.V. and James, A. and Janson, C. and Jarvelin, M.R. and Jarvis, D. and Jones, G. and Jonsdottir, I. and Jousilahti, P. and Kabesch, M. and Kähönen, M. and Kantor, D.B. and Karunas, A.S. and Khusnutdinova, E. and Koppelman, G.H. and Kozyrskyj, A.L. and Kreiner, E. and Kubo, M. and Kumar, R. and Kumar, A. and Kuokkanen, M. and Lahousse, L. and Laitinen, T. and Laprise, C. and Lathrop, M. and Lau, S. and Lee, Y.A. and Lehtimaeki, T. and Letort, S. and Levin, A.M. and Li, G. and Liang, L. and Loehr, L.R. and London, S.J. and Loth, D.W. and Manichaikul, A. and Marenholz, I. and Martinez, F.J. and Matheson, M.C. and Mathias, R.A. and Matsumoto, K. and Mbarek, H. and McArdle, W.L. and Melbye, M. and Melen, E. and Meyers, D. and Michel, S. and Mohamdi, H. and Musk, A.W. and Myers, R.A. and Nieuwenhuis, M.A.E. and Noguchi, E. and O'Connor, G.T. and Ogorodova, L.M. and Palmer, C.D. and Palotie, A. and Park, J.E. and Pennell, C.E. and Pershagen, G. and Polonikov, A. and Postma, D.S. and Probst-Hensch, N. and Puzyrev, V.P. and Raby, B.A. and Raitakari, O.T. and Ramasamy, A. and Rich, S.S. and Robertson, C.F. and Romieu, I. and Salam, M.T. and Salomaa, V. and Schluenssen, V. and Scott, R. and Selivanova, P.A. and Sigsgaard, T. and Simpson, A. and Siroux, V. and Smith, L.J. and Solodilova, M. and Standl, M. and Stefansson, K. and Strachan, D.P. and Stricker, B.H. and Takahashi, A. and Thompson, P.J. and Thorleifsson, G. and Thorsteinsdottir, U. and Tiesler, C.M.T. and Torgerson, D.G. and Tsunoda, T. and Uitterlinden, A.G. and van der Valk, R.J.P. and Vaysse, A. and Vedantam, S. and von Berg, A. and von Mutius, E. and Vonk, J.M. and Waage, J. and Wareham, N.J. and Weiss, S.T. and White, W.B. and Wickman, M. and Widén, E. and Willemsen, G. and Williams, L.K. and Wouters, I.M. and Yang, J.J. and Zhao, J.H. and Moffatt, M.F. and Ober, C. and Nicolae, D.L.
Nature Genetics 50 (1): 42-53. January 2018

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Lancet 392 (10159): 1923-1994. 2018

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.
Verduci, L. and Ferraiuolo, M. and Sacconi, A. and Ganci, F. and Vitale, J. and Colombo, T. and Paci, P. and Strano, S. and Macino, G. and Rajewsky, N. and Blandino, G.
Genome Biology 18 (1): 237. 20 December 2017

Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M. and Gallion, J. and Picard, L.P. and Wilkins, A.D. and Le Gouill, C. and Audet, M. and Stallaert, W. and Lohse, M.J. and Kimmel, M. and Lichtarge, O. and Bouvier, M.
Nature Communications 8 (1): 2169. 18 December 2017

IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S. and Viswanathan, S. and Widjaja, A.A. and Lim, W.W. and Moreno-Moral, A. and DeLaughter, D.M. and Ng, B. and Patone, G. and Chow, K. and Khin, E. and Tan, J. and Chothani, S.P. and Ye, L. and Rackham, O.J. and Ko, N.S. and Sahib, N.E. and Pua, C.J. and Zhen, N.T. and Xie, C. and Wang, M. and Maatz, H. and Lim, S. and Saar, K. and Blachut, S. and Petretto, E. and Schmidt, S. and Putoczki, T. and Guimarães-Camboa, N. and Wakimoto, H. and van Heesch, S. and Sigmundsson, K. and Lim, S.L. and Soon, J.L. and Chao, V.T. and Chua, Y.L. and Tan, T.E. and Evans, S.M. and Loh, Y.J. and Jamal, M.H. and Ong, K.K. and Chua, K.C. and Ong, B.H. and Chakaramakkil, M.J. and Seidman, J.G. and Seidman, C.E. and Hubner, N. and Sin, K.Y. and Cook, S.A.
Nature 552 (7683): 110-115. 7 December 2017

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F. and Haas, J. and Zhu, F. and Geier, C. and Kayvanpour, E. and Liss, M. and Lai, A. and Frese, K. and Pribe-Wolferts, R. and Amr, A. and Li, D.T. and Samani, O.S. and Carstensen, A. and Bordalo, D.M. and Müller, M. and Fischer, C. and Shao, J. and Wang, J. and Nie, M. and Yuan, L. and Haßfeld, S. and Schwartz, C. and Zhou, M. and Zhou, Z. and Shu, Y. and Wang, M. and Huang, K. and Zeng, Q. and Cheng, L. and Fehlmann, T. and Ehlermann, P. and Keller, A. and Dieterich, C. and Streckfuß-Bömeke, K. and Liao, Y. and Gotthardt, M. and Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y. and Zhao, Y. and Jiang, L.L. and Li, X. and Liu, Y. and Sun, Y. and Piña-Crespo, J.C. and Zhu, B. and Masliah, E. and Willnow, T.E. and Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214 (12): 3669-3685. 4 December 2017

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A. and Dejanovic, B. and Hetsch, F. and Semtner, M. and Fusca, D. and Arjune, S. and Santamaria-Araujo, J.A. and Winkelmann, A. and Ayton, S. and Bush, A.I. and Kloppenburg, P. and Meier, J.C. and Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127 (12): 4365-4378. 1 December 2017

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Mathivet, T. and Bouleti, C. and Van Woensel, M. and Stanchi, F. and Verschuere, T. and Phng, L.K. and Dejaegher, J. and Balcer, M. and Matsumoto, K. and Georgieva, P.B. and Belmans, J. and Sciot, R. and Stockmann, C. and Mazzone, M. and De Vleeschouwer, S. and Gerhardt, H.
EMBO Molecular Medicine 9 (12): 1629-1645. 1 December 2017

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.
Eichenauer, D.A. and Plütschow, A. and Kreissl, S. and Sökler, M. and Hellmuth, J.C. and Meissner, J. and Mathas, S. and Topp, M.S. and Behringer, K. and Klapper, W. and Kuhnert, G. and Dietlein, M. and Kobe, C. and Fuchs, M. and Diehl, V. and Engert, A. and Borchmann, P.
Lancet Oncology 18 (12): 1680-1687. December 2017

Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N. and Matus, M.G. and Kearney, S.M. and Olesen, S.W. and Forslund, K. and Bartolomaeus, H. and Haase, S. and Mähler, A. and Balogh, A. and Markó, L. and Vvedenskaya, O. and Kleiner, F.H. and Tsvetkov, D. and Klug, L. and Costea, P.I. and Sunagawa, S. and Maier, L. and Rakova, N. and Schatz, V. and Neubert, P. and Frätzer, C. and Krannich, A. and Gollasch, M. and Grohme, D.A. and Côrte-Real, B.F. and Gerlach, R.G. and Basic, M. and Typas, A. and Wu, C. and Titze, J.M. and Jantsch, J. and Boschmann, M. and Dechend, R. and Kleinewietfeld, M. and Kempa, S. and Bork, P. and Linker, R.A. and Alm, E.J. and Müller, D.N.
Nature 551 (7682): 585-589. 30 November 2017

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Sassi, Y. and Avramopoulos, P. and Ramanujam, D. and Grüter, L. and Werfel, S. and Giosele, S. and Brunner, A.D. and Esfandyari, D. and Papadopoulou, A.S and De Strooper, B. and Hübner, N. and Kumarswamy, R. and Thum, T. and Yin, X. and Mayr, M. and Laggerbauer, B. and Engelhardt, S.
Nature Communications 8 (1): 1614. 20 November 2017

Transient cardiomyocyte fusion regulates cardiac development in zebrafish.
Sawamiphak, S. and Kontarakis, Z. and Filosa, A. and Reischauer, S. and Stainier, D.Y.R.
Nature Communications 8 (1): 1525. 15 November 2017

Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J. and Singh, M. and Herse, F. and Przybyl, L. and Haase, N. and Golic, M. and Yung, H.W. and Huppertz, B. and Cartwright, J.E. and Whitley, G.S. and Johnsen, G.M. and Levi, G. and Isbruch, A. and Schulz, H. and Luft, F.C. and Müller, D.N. and Staff, A.C. and Hurst, L.D. and Dechend, R. and Izsvák, Z.
Circulation 136 (19): 1824-1839. 7 November 2017

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
Chen, X. and Poncette, L. and Blankenstein, T.
Journal of Experimental Medicine 214 (11): 3417-3433. 6 November 2017

ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
Heller, D. and Krestel, R. and Ohler, U. and Vingron, M. and Marsico, A.
Nucleic Acids Research 45 (19): 11004-11018. 2 November 2017

Towards standards for human fecal sample processing in metagenomic studies.
Costea, P.I. and Zeller, G. and Sunagawa, S. and Pelletier, E. and Alberti, A. and Levenez, F. and Tramontano, M. and Driessen, M. and Hercog, R. and Jung, F.E. and Kultima, J.R. and Hayward, M.R. and Coelho, L.P. and Allen-Vercoe, E. and Bertrand, L. and Blaut, M. and Brown, J.R.M. and Carton, T. and Cools-Portier, S. and Daigneault, M. and Derrien, M. and Druesne, A. and de Vos, W.M. and Finlay, B.B. and Flint, H.J. and Guarner, F. and Hattori, M. and Heilig, H. and Luna, R.A. and van Hylckama Vlieg, J. and Junick, J. and Klymiuk, I. and Langella, P. and Le Chatelier, Z. and Mai, V. and Manichanh, C. and Martin, J.C. and Mery, C. and Morita, H. and O'Toole, P.W. and Orvain, C. and Patil, K.R. and Penders, J. and Persson, S. and Pons, N. and Popova, M. and Salonen, A. and Saulnier, D. and Scott, K.P. and Singh, B. and Slezak, K. and Veiga, P. and Versalovic, J. and Zhao, L. and Zoetendal, E.G. and Ehrlich, S.D. and Dore, J. and Bork, P.
Nature Biotechnology 35 (11): 1069-1076. November 2017

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
Hehlmann, R. and Lauseker, M. and Saußele, S. and Pfirrmann, M. and Krause, S. and Kolb, H.J. and Neubauer, A. and Hossfeld, D.K. and Nerl, C. and Gratwohl, A. and Baerlocher, G.M. and Heim, D. and Brümmendorf, T.H. and Fabarius, A. and Haferlach, C. and Schlegelberger, B. and Müller, M.C. and Jeromin, S. and Proetel, U. and Kohlbrenner, K. and Voskanyan, A. and Rinaldetti, S. and Seifarth, W. and Spieß, B. and Balleisen, L. and Goebeler, M.C. and Hänel, M. and Ho, A. and Dengler, J. and Falge, C. and Kanz, L. and Kremers, S. and Burchert, A. and Kneba, M. and Stegelmann, F. and Köhne, C.A. and Lindemann, H.W. and Waller, C.F. and Pfreundschuh, M. and Spiekermann, K. and Berdel, W.E. and Müller, L. and Edinger, M. and Mayer, J. and Beelen, D.W. and Bentz, M. and Link, H. and Hertenstein, B. and Fuchs, R. and Wernli, M. and Schlegel, F. and Schlag, R. and de Wit, M. and Trümper, L. and Hebart, H. and Hahn, M. and Thomalla, J. and Scheid, C. and Schafhausen, P. and Verbeek, W. and Eckart, M.J. and Gassmann, W. and Pezzutto, A. and Schenk, M. and Brossart, P. and Geer, T. and Bildat, S. and Schäfer, E. and Hochhaus, A. and Hasford, J.
Leukemia 31 (11): 2398-2406. November 2017

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
Dimitrakopoulou, V.I. and Tsilidis, K.K. and Haycock, P.C. and Dimou, N.L. and Al-Dabhani, K. and Martin, R.M. and Lewis, S.J. and Gunter, M.J. and Mondul, A. and Shui, I.M. and Theodoratou, E. and Nimptsch, K. and Lindstroem, S. and Albanes, D. and Kuehn, T. and Key, T.J. and Travis, R.C. and Vimaleswaran, K.S. and Kraft, P. and Pierce, B.L. and Schildkraut, J.M.
BMJ 359 : j4761. 31 October 2017

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E. and Menegatti, J. and Franke, V. and Kocks, C. and Boltengagen, A. and Hennig, T. and Theil, K. and Rutkowski, A. and Ferrai, C. and Baer, L. and Kermas, L. and Friedel, C. and Rajewsky, N. and Akalin, A. and Dölken, L. and Grässer, F. and Landthaler, M.
Genome Biology 18 (1): 209. 31 October 2017

McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
Hafez, D. and Karabacak, A. and Krueger, S. and Hwang, Y.C. and Wang, L.S. and Zinzen, R.P. and Ohler, U.
Genome Biology 18 (1): 199. 26 October 2017

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T. and Jobin, M.L. and Burnecki, K. and Weron, A. and Lohse, M.J. and Calebiro, D.
Nature 550 (7677): 543-547. 26 October 2017

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I. and Grosche, S. and Kalb, B. and Rüschendorf, F. and Blümchen, K. and Schlags, R. and Harandi, N. and Price, M. and Hansen, G. and Seidenberg, J. and Röblitz, H. and Yürek, S. and Tschirner, S. and Hong, X. and Wang, X. and Homuth, G. and Schmidt, C.O. and Nöthen, M.M. and Hübner, N. and Niggemann, B. and Beyer, K. and Lee, Y.A.
Nature Communications 8 (1): 1056. 20 October 2017

The Drosophila embryo at single-cell transcriptome resolution.
Karaiskos, N. and Wahle, P. and Alles, J. and Boltengagen, A. and Ayoub, S. and Kipar, C. and Kocks, C. and Rajewsky, N. and Zinzen, R.P.
Science 358 (6360): 194-199. 13 October 2017

Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.
Lacraz, G.P.A. and Junker, J.P. and Gladka, M.M. and Molenaar, B. and Scholman, K.T. and Vigil-Garcia, M. and Versteeg, D. and de Ruiter, H. and Vermunt, M.W. and Creyghton, M.P. and Huibers, M.M.H. and de Jonge, N. and van Oudenaarden, A. and van Rooij, E.
Circulation 136 (15): 1396-1409. 10 October 2017

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Elling, U. and Wimmer, R.A. and Leibbrandt, A. and Burkard, T. and Michlits, G. and Leopoldi, A. and Micheler, T. and Abdeen, D. and Zhuk, S. and Aspalter, I.M. and Handl, C. and Liebergesell, J. and Hubmann, M. and Husa, A.M. and Kinzer, M. and Schuller, N. and Wetzel, E. and van de Loo, N. and Martinez, J.A.Z. and Estoppey, D. and Riedl, R. and Yang, F. and Fu, B. and Dechat, T. and Ivics, Z. and Agu, C.A. and Bell, O. and Blaas, D. and Gerhardt, H. and Hoepfner, D. and Stark, A. and Penninger, J.M.
Nature 550 (7674): 114-118. 5 October 2017

Developmental origin and maintenance of distinct testicular macrophage populations.
Mossadegh-Keller, N. and Gentek, R. and Gimenez, G. and Bigot, S. and Mailfert, S. and Sieweke, M.H.
Journal of Experimental Medicine 214 (10): 2829-2841. 2 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A. and van den Bruck, D. and Ciolli Mattioli, C. and Franke, V. and Imami, K. and McShane, E. and Moreno-Estelles, M. and Calviello, L. and Filipchyk, A. and Peguero-Sanchez, E. and Müller, T. and Woehler, A. and Birchmeier, C. and Merino, E. and Rajewsky, N. and Ohler, U. and Mazzoni, E.O. and Selbach, M. and Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

The 4D nucleome project.
Dekker, J. and Belmont, A.S. and Guttman, M. and Leshyk, V.O. and Lis, J.T. and Lomvardas, S. and Mirny, L.A. and O'Shea, C.C. and Park, P.J. and Ren, B. and Politz, J.C.R. and Shendure, J. and Zhong, S.
Nature 549 (7671): 219-226. 14 September 2017

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Heinig, M. and Adriaens, M.E. and Schafer, S. and van Deutekom, H.W.M. and Lodder, E.M. and Ware, J.S. and Schneider, V. and Felkin, L.E. and Creemers, E.E. and Meder, B. and Katus, H.A. and Rühle, F. and Stoll, M. and Cambien, F. and Villard, E. and Charron, P. and Varro, A. and Bishopric, N.H. and George, A.L. and Dos Remedios, C. and Moreno-Moral, A. and Pesce, F. and Bauerfeind, A. and Rüschendorf, F. and Rintisch, C. and Petretto, E. and Barton, P.J. and Cook, S.A. and Pinto, Y.M. and Bezzina, C.R. and Hubner, N.
Genome Biology 18 (1): 170. 14 September 2017

A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
Boege, Y. and Malehmir, M. and Healy, M.E. and Bettermann, K. and Lorentzen, A. and Vucur, M. and Ahuja, A.K. and Böhm, F. and Mertens, J.C. and Shimizu, Y. and Frick, L. and Remouchamps, C. and Mutreja, K. and Kähne, T. and Sundaravinayagam, D. and Wolf, M.J. and Rehrauer, H. and Koppe, C. and Speicher, T. and Padrissa-Altés, S. and Maire, R. and Schattenberg, J.M. and Jeong, J.S. and Liu, Lei and Zwirner, S. and Boger, R. and Hüser, N. and Davis, R.J. and Müllhaupt, B. and Moch, H. and Schulze-Bergkamen, H. and Clavien, P.A. and Werner, S. and Borsig, L. and Luther, S.A. and Jost, P.J. and Weinlich, R. and Unger, K. and Behrens, A. and Hillert, L. and Dillon, C. and Di Virgilio, M. and Wallach, D. and Dejardin, E. and Zender, L. and Naumann, M. and Walczak, H. and Green, D.R. and Lopes, M. and Lavrik, I. and Luedde, T. and Heikenwalder, M. and Weber, A.
Cancer Cell 32 (3): 342-359. 11 September 2017

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S. and Witte, N. and Weber, P. and Goehring, I. and Tolkachov, A. and von Loeffelholz, C. and Döcke, S. and Bauer, M. and Stockmann, M. and Pfeiffer, A.F.H. and Birkenfeld, A.L. and Pietzke, M. and Kempa, S. and Muenzner, M. and Schupp, M.
Nature Communications 8 (1): 384. 30 August 2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F. and Maurizio, J. and Vargas Aguilar, S. and Busch, C.J. and Favret, J. and Kowenz-Leutz, E. and Cathou, W. and Gentek, R. and Perrin, P. and Leutz, A. and Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C. and Werner, A. and John, D. and Boeckel, J.-N. and Melissari, M.-T. and Grote, P. and Glaser, S.F. and Demolli, S. and Uchida, S. and Michalik, K.M. and Meder, B. and Katus, H.A. and Haas, J. and Chen, W. and Pullamsetti, S.S. and Seeger, W. and Zeiher, A.M. and Dimmeler, S. and Zehendner, C.M.
Circulation Research 121 (4): 368-375. 4 August 2017

Fast genome-wide functional annotation through orthology assignment by eggNOG-mapper.
Huerta-Cepas, J. and Forslund, K. and Coelho, L.P. and Szklarczyk, D. and Jensen, L.J. and von Mering, C. and Bork, P.
Molecular Biology and Evolution 34 (8): 2115-2122. 1 August 2017

Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies.
Rohr, U.P. and Herrmann, P. and Ilm, K. and Zhang, H. and Lohmann, S. and Reiser, A. and Muranyi, A. and Smith, J. and Burock, S. and Osterland, M. and Leith, K. and Singh, S. and Brunhoeber, P. and Bowermaster, R. and Tie, J. and Christie, M. and Wong, H.L. and Waring, P. and Shanmugam, K. and Gibbs, P. and Stein, U.
Annals of Oncology 28 (8): 1869-1875. 1 August 2017

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
Herce, H.D. and Schumacher, D. and Schneider, A.F.L. and Ludwig, A.K. and Mann, F.A. and Fillies, M. and Kasper, M.-A. and Reinke, S. and Krause, E. and Leonhardt, H. and Cardoso, M.C. and Hackenberger, C.P.R.
Nature Chemistry 9 (8): 762-771. August 2017

DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M. and Imami, K. and Mukherjee, N. and De Bortoli, F. and Zinnall, U. and Hazapis, O. and Trahan, C. and Oeffinger, M. and Heyd, F. and Ohler, U. and Selbach, M. and Landthaler, M.
Genome Research 27 (8): 1344-1359. August 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T. and Yan, X. and Kononenko, N.L. and Ku, M.C. and Song, K. and Ferrarese, L. and Tarallo, V. and Puchkov, D. and Kochlamazashvili, G. and Brachs, S. and Varela, L. and Szigeti-Buck, K. and Yi, C.X. and Schriever, S.C. and Tattikota, S.G. and Carlo, A.S. and Moroni, M. and Siemens, J. and Heuser, A. and van der Weyden, L. and Birkenfeld, A.L. and Niendorf, T. and Poulet, J.F.A. and Horvath, T.L. and Tschöp, M.H. and Heinig, M. and Trajkovski, M. and Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V. and Birdsey, G.M. and Peghaire, C. and Pitulescu, M.E. and Dufton, N.P. and Yang, Y. and Weinberg, I. and Osuna Almagro, L. and Payne, L. and Mason, J.C. and Gerhardt, H. and Adams, R.H. and Randi, A.M.
Nature Communications 8 : 16002. 11 July 2017

The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure, F.R. and Royla, N. and Herold, S. and Kalb, J. and Walz, S. and Ade, C.P. and Mastrobuoni, G. and Vanselow, J.T. and Schlosser, A. and Wolf, E. and Kempa, S. and Eilers, M.
EMBO Journal 36 (13): 1854-1868. 3 July 2017

Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
Eulenberg-Gustavus, C. and Bähring, S. and Maass, P. and Luft, F.C. and Kettritz, R.
Journal of Experimental Medicine 214 (7): 2089-2101. 3 July 2017

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
Grüning, B.A. and Fallmann, J. and Yusuf, D. and Will, S. and Erxleben, A. and Eggenhofer, F. and Houwaart, T. and Batut, B. and Videm, P. and Bagnacani, A. and Wolfien, M. and Lott, S.C. and Hoogstrate, Y. and Hess, W.R. and Wolkenhauer, O. and Hoffmann, S. and Akalin, A. and Ohler, U. and Stadler, P.F. and Backofen, R.
Nucleic Acids Research 45 (W1): W560-W566. 3 July 2017

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J. and Novitzky-Basso, I. and Thiriot, A. and Casanova-Acebes, M. and Bianchini, M. and Etheridge, S.L. and Hub, E. and Nitz, K. and Artinger, K. and Eller, K. and Caamano, J. and Ruelicke, T. and Moss, P. and Megens, R.T.A. and von Andrian, U.H. and Hidalgo, A. and Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.
Young, E. and Noerenberg, D. and Mansouri, L. and Ljungström, V. and Frick, M. and Sutton, L.A. and Blakemore, S.J. and Galan-Sousa, J. and Plevova, K. and Baliakas, P. and Rossi, D. and Clifford, R. and Roos-Weil, D. and Navrkalova, V. and Dörken, B. and Schmitt, C.A. and Smedby, K.E. and Juliusson, G. and Giacopelli, B. and Blachly, J.S. and Belessi, C. and Panagiotidis, P. and Chiorazzi, N. and Davi, F. and Langerak, A.W. and Oscier, D. and Schuh, A. and Gaidano, G. and Ghia, P. and Xu, W. and Fan, L. and Bernard, O.A. and Nguyen-Khac, F. and Rassenti, L. and Li, J. and Kipps, T.J. and Stamatopoulos, K. and Pospisilova, S. and Zenz, T. and Oakes, C.C. and Strefford, J.C. and Rosenquist, R. and Damm, F.
Leukemia 31 (7): 1547-1554. July 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.
Kar, G. and Kim, J.K. and Kolodziejczyk, A.A. and Natarajan, K.N. and Torlai Triglia, E. and Mifsud, B. and Elderkin, S. and Marioni, J.C. and Pombo, A. and Teichmann, S.A.
Nature Communications 8 (1): 36. 26 June 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F. and Rapp, A. and Yu, W. and Maiser, A. and Harz, H. and Scholl, A. and Grulich, S. and Anton, T. and Hoerl, D. and Chen, W. and Durante, M. and Taucher-Scholz, G. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G. and Raffel, S. and Sormani, M. and Zanardi, F. and Lonardi, S. and Zasada, C. and Perucho, L. and Petrocelli, V. and Haake, A. and Lee, A.K. and Bugatti, M. and Paul, U. and Van Anken, E. and Pasqualucci, L. and Rabadan, R. and Siebert, R. and Kempa, S. and Ponzoni, M. and Facchetti, F. and Rajewsky, K. and Casola, S.
Nature 546 (7657): 302-306. 8 June 2017

RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Uyar, B. and Yusuf, D. and Wurmus, R. and Rajewsky, N. and Ohler, U. and Akalin, A.
Nucleic Acids Research 45 (10): e91. 2 June 2017

Tracking the evolution of non-small-cell lung cancer.
Jamal-Hanjani, M. and Wilson, G.A. and McGranahan, N. and Birkbak, N.J. and Watkins, T.B.K. and Veeriah, S. and Shafi, S. and Johnson, D.H. and Mitter, R. and Rosenthal, R. and Salm, M. and Horswell, S. and Escudero, M. and Matthews, N. and Rowan, A. and Chambers, T. and Moore, D.A. and Turajlic, S. and Xu, H. and Lee, S.-M. and Forster, M.D. and Ahmad, T. and Hiley, C.T. and Abbosh, C. and Falzon, M. and Borg, E. and Marafioti, T. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P.A. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Dentro, S. and Taniere, P. and O'Sullivan, B. and Lowe, H.L. and Hartley, J.A. and Iles, N. and Bell, H. and Ngai, Y. and Shaw, J.A. and Herrero, J. and Szallasi, Z. and Schwarz, R.F. and Stewart, A. and Quezada, S.A. and Le Quesne, J. and Van Loo, P. and Dive, C. and Hackshaw, A. and Swanton, C.
New England Journal of Medicine 376 (22): 2109-2121. 1 June 2017

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.
Barbieri, M. and Xie, S.Q. and Torlai Triglia, E. and Chiariello, A.M. and Bianco, S. and de Santiago, I. and Branco, M.R. and Rueda, D. and Nicodemi, M. and Pombo, A.
Nature Structural & Molecular Biology 24 (6): 515-524. June 2017

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Tay, T.L. and Mai, D. and Dautzenberg, J. and Fernández-Klett, F. and Lin, G. and Sagar, D.M. and Datta, M. and Drougard, A. and Stempfl, T. and Ardura-Fabregat, A. and Staszewski, O. and Margineanu, A. and Sporbert, A. and Steinmetz, L.M. and Pospisilik, J.A. and Jung, S. and Priller, J. and Grün, D. and Ronneberger, O. and Prinz, M.
Nature Neuroscience 20 (6): 793-803. June 2017

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M. and Zerbes, R.M. and Rampelt, H. and Kunz, S. and Xavier, A.H. and Purfürst, B. and Lilie, H. and Pfanner, N. and van der Laan, M. and Daumke, O.
Nature Communications 8 : 15258. 31 May 2017

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Nature 545 (7655): 446-451. 25 May 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. and Schönheit, J. and Giladi, A. and David, E. and Lara-Astiaso, D. and Lorenzo-Vivas, E. and Paul, F. and Chappell-Maor, L. and Priller, J. and Leutz, A. and Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I. and Termglinchan, V. and Cepeda, D.A. and Lee, J. and Diecke, S. and Hendel, A. and Itzhaki, I. and Ameen, M. and Shrestha, R. and Wu, H. and Ma, N. and Shao, N.Y. and Seeger, T. and Woo, N.A. and Wilson, K.D. and Matsa, E. and Porteus, M.H. and Sebastiano, V. and Wu, J.C.
Circulation Research 120 (10): 1561-1571. 12 May 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K. and Daub, S. and Zhang, Y. and Klein, J. D. and Nakano, D. and Pedchenko, T. and Lantier, L. and LaRocque, L.M. and Marton, A. and Neubert, P. and Schröder, A. and Rakova, N. and Jantsch, J. and Dikalova, A.E. and Dikalov, S.I. and Harrison, D.G. and Müller, D.N. and Nishiyama, A. and Rauh, M. and Harris, R. C. and Luft, F.C. and Wassermann, D.H. and Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127 (5): 1944-1959. 1 May 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N. and Kitada, K. and Lerchl, K. and Dahlmann, A. and Birukov, A. and Daub, S. and Kopp, C. and Pedchenko, T. and Zhang, Y. and Beck, L. and Johannes, B. and Marton, A. and Müller, D.N. and Rauh, M. and Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127 (5): 1932-1943. 1 May 2017

Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
Vöpel, T. and Bravo-Rodriguez, K. and Mittal, S. and Vachharajani, S. and Gnutt, D. and Sharma, A. and Steinhof, A. and Fatoba, O. and Ellrichmann, G. and Nshanian, M. and Heid, C. and Loo, J.A. and Klärner, F.-G. and Schrader, T. and Bitan, G. and Wanker, E.E. and Ebbinghaus, S. and Sanchez-Garcia, E.
Journal of the American Chemical Society 139 (16): 5640-5643. 26 April 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S. and Zharkov, D.O. and Stahl, J. and Gopanenko, Al.V. and Tupikin, A.E. and Kabilov, M.R. and Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45 (7): 3833-3843. 20 April 2017

Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.
Legnini, I. and Di Timoteo, G. and Rossi, F. and Morlando, M. and Briganti, F. and Sthandier, O. and Fatica, A. and Santini, T. and Andronache, A. and Wade, M. and Laneve, P. and Rajewsky, N. and Bozzoni, I.
Molecular Cell 66 (1): 22-37.e9. 6 April 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Initiation of acute graft-versus-host disease by angiogenesis.
Riesner, K. and Shi, Y. and Jacobi, A. and Kräter, M. and Kalupa, M. and McGearey, A. and Mertlitz, S. and Cordes, S. and Schrezenmeier, J.F. and Mengwasser, J. and Westphal, S. and Perez-Hernandez, D. and Schmitt, C. and Dittmar, G. and Guck, J. and Penack, O.
Blood 129 (14): 2021-2032. 6 April 2017

Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing, S. and Rudnik, S. and Damme, M. and Luellmann-Rauch, R. and Ichihara, A. and Kornak, U. and Eskelinen, E.L. and Jabs, S. and Heeren, J. and De Brabander, J.K. and Haas, A. and Saftig, P.
Autophagy 13 (4): 670-685. April 2017

Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie, R.A. and Scialdone, A. and Schueler, M. and Kraemer, D.C.A. and Chotalia, M. and Xie, S.Q. and Barbieri, M. and de Santiago, I. and Lavitas, L.M. and Branco, M.R. and Fraser, J. and Dostie, J. and Game, L. and Dillon, N. and Edwards, P.A.W. and Nicodemi, M. and Pombo, A.
Nature 543 (7646): 519-524. 23 March 2017

Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O. and de Jong, T. and Mata-Cabana, A. and Kudron, M. and Zaini, M.A. and Aprile, F.A. and Seinstra, R.I. and Stroo, E. and Prins, R.W. and Martineau, C.N. and Wang, H.H. and Hogewerf, Wytse and Steinhof, A. and Wanker, E.E. and Vendruscolo, M. and Calkhoven, C.F. and Reinke, V. and Guryev, V. and Nollen, E.A.A.
Molecular Cell 65 (6): 1096-1108. 16 March 2017

The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association.
Mancia, G. and Oparil, S. and Whelton, P.K. and McKee, M. and Dominiczak, A. and Luft, F.C. and AlHabib, K. and Lanas, F. and Damasceno, A. and Prabhakaran, D. and La Torre, G. and Weber, M. and O'Donnell, M. and Smith, S.C. and Narula, J.
European Heart Journal 38 (10): 712-719. 7 March 2017

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D. and Hummel, F. and Richter, J. and Giefing, M. and Hartmann, S. and Hansmann, M.L. and Kreher, S. and Köchert, K. and Krappmann, D. and Klapper, W. and Hummel, M. and Wenzel, S.S. and Lenz, G. and Janz, M. and Dörken, B. and Siebert, R. and Mathas, S.
Leukemia 31 (3): 602-613. March 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N. and Naumann, H. and Ruzittu, S. and Mah, N. and Pongrac, I.M. and Cozzitorto, C. and Hommel, A. and Andrade-Navarro, M.A. and Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells.
Velasco, S. and Ibrahim, M.M. and Kakumanu, A. and Garipler, G. and Aydin, B. and Al-Sayegh, M.A. and Hirsekorn, A. and Abdul-Rahman, F. and Satija, R. and Ohler, U. and Mahony, S. and Mazzoni, E.O.
Cell Stem Cell 20 (2): 205-217. 2 February 2017

Scattering compensation by focus scanning holographic aberration probing (F-SHARP).
Papadopoulos, I.N. and Jouhanneau, J.S. and Poulet, J.F.A. and Judkewitz, B.
Nature Photonics 11 (2): 116-123. February 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C. and Pifferi, S. and Picci, C. and Gök, C. and Hoffmann, D. and Bali, K.K. and Lampe, A. and Lapatsina, L. and Fleischer, R. and Smith, E.S.J. and Bégay, V. and Moroni, M. and Estebanez, L. and Kühnemund, J. and Walcher, J. and Specker, E. and Neuenschwander, M. and von Kries, J.P. and Haucke, V. and Kuner, R. and Poulet, J.F.A. and Schmoranzer, J. and Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S. and Childs, L.H. and Aust, D. and Heim, D. and Melching, F. and Oliveira, C. and Wolf, T. and Durek, P. and Schumacher, D. and Blaeker, H. and von Winterfeld, M. and Gastl, B. and Moehr, K. and Menne, A. and Zeugner, S. and Redmer, T. and Lenze, D. and Tierling, S. and Moebs, M. and Weichert, W. and Folprecht, G. and Blanc, E. and Beule, D. and Schaefer, R. and Morkel, M. and Klauschen, F. and Leser, U. and Sers, C.
Nature Communications 8 : 14093. 25 January 2017

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M. and Kirchner, M. and Aharoni, R. and Ciolli Mattioli, C. and van den Bruck, D. and Gutkovitch, N. and Modepalli, V. and Selbach, M. and Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45 (2): 938-950. 25 January 2017

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Dehghani Amirabad, A. and Behjati Ardakani, F. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
Nucleic Acids Research 45 (1): 54-66. 9 January 2017

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y. and Pryputniewicz-Dobrinska, D. and Nagy, E.E. and Kaufman, C.D. and Singh, M. and Yant, S. and Wang, J. and Dalda, A. and Kay, M.A. and Ivics, Z. and Izsvák, Z.
Nucleic Acids Research 45 (1): 311-326. 9 January 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 5 January 2017

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A. and Gorham, L. and Dhandapani, R. and Prato, V. and Taberner, F.J. and Wende, H. and Gangadharan, V. and Birchmeier, C. and Heppenstall, P.A. and Lechner, S.G.
Neuron 93 (1): 179-193. 4 January 2017

OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines.
Chen, W.H. and Lu, G. and Chen, X. and Zhao, X.M. and Bork, P.
Nucleic Acids Research 45 (D1): D940-D944. 4 January 2017

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
Mende, D.R. and Letunic, I. and Huerta-Cepas, J. and Li, S.S. and Forslund, K. and Sunagawa, S. and Bork, P.
Nucleic Acids Research 45 (D1): D529-D534. 4 January 2017

The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Szklarczyk, D. and Morris, J.H. and Cook, H. and Kuhn, M. and Wyder, S. and Simonovic, M. and Santos, A. and Doncheva, N.T. and Roth, A. and Bork, P. and Jensen, L.J. and von Mering, C.
Nucleic Acids Research 45 (D1): D362-D368. 4 January 2017

Integrative classification of human coding and noncoding genes through RNA metabolism profiles.
Mukherjee, N. and Calviello, L. and Hirsekorn, A. and de Pretis, S. and Pelizzola, M. and Ohler, U.
Nature Structural & Molecular Biology 24 (1): 86-96. January 2017

Titin-truncating variants affect heart function in disease cohorts and the general population.
Schafer, S. and de Marvao, A. and Adami, E. and Fiedler, L.R. and Ng, B. and Khin, E. and Rackham, O.J.L. and van Heesch, S. and Pua, C.J. and Kui, M. and Walsh, R. and Tayal, U. and Prasad, S.K. and Dawes, T.J.W. and Ko, N.S.J. and Sim, D. and Chan, L.L.H. and Chin, C.W.L. and Mazzarotto, F. and Barton, P.J. and Kreuchwig, F. and de Kleijn, D.P.V. and Totman, T. and Biffi, C. and Tee, N. and Rueckert, D. and Schneider, V. and Faber, A. and Regitz-Zagrosek, V. and Seidman, J.G. and Seidman, C.E. and Linke, W.A. and Kovalik, J.P. and O'Regan, D. and Ware, J.S. and Hubner, N. and Cook, S.A.
Nature Genetics 49 (1): 46-53. January 2017

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S. and Bolcho, U. and Molgaard, S. and Bøggild, S. and Vaegter, C.B. and Smith, A.H. and Nieto-Gonzalez, J.L. and Ovesen, P.L. and Pedersen, L.F. and Fjorback, A.N. and Kjolby, M. and Login, H. and Holm, M.M. and Andersen, O.M. and Nyengaard, J.R. and Willnow, T.E. and Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21 (12): 1740-1751. December 2016

DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L. and Nanda, I. and Evangelou, K. and Nikolova, T. and Horn, V. and Sagar, and Erny, D. and Stefanowski, J. and Rogell, L. and Klein, C. and Gharun, K. and Follo, M. and Seidl, M. and Kremer, B. and Münke, N. and Senges, J. and Fliegauf, M. and Aschman, T. and Pfeifer, D. and Sarrazin, S. and Sieweke, M.H. and Wagner, D. and Dierks, C. and Haaf, T. and Ness, T. and Zaiss, M.M. and Voll, R.E. and Deshmukh, S.D. and Prinz, M. and Goldmann, T. and Hölscher, C. and Hauser, A.E. and Lopez-Contreras, A.J. and Grün, D. and Gorgoulis, V. and Diefenbach, A. and Henneke, P. and Triantafyllopoulou, A.
Cell 167 (5): 1264-1280. 17 November 2016

The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Stunnenberg, H.G. and Hirst, M.
Cell 167 (7): 1145-1149. 17 November 2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P. and Nordström, K. and Gasparoni, G. and Salhab, A. and Kressler, C. and de Almeida, M. and Bassler, K. and Ulas, T. and Schmidt, F. and Xiong, J. and Glažar, P. and Klironomos, F. and Sinha, A. and Kinkley, S. and Yang, X. and Arrigoni, L. and Amirabad, A.. and Ardakani, F.B. and Feuerbach, L. and Gorka, O. and Ebert, P. and Müller, F. and Li, N. and Frischbutter, S. and Schlickeiser, S. and Cendon, C. and Fröhler, S. and Felder, B. and Gasparoni, N. and Imbusch, C.D. and Hutter, B. and Zipprich, G. and Tauchmann, Y. and Reinke, S. and Wassilew, G. and Hoffmann, U. and Richter, A.S. and Sieverling, L. and Chang, H.D. and Syrbe, U. and Kalus, U. and Eils, J. and Brors, B. and Manke, T. and Ruland, J. and Lengauer, T. and Rajewsky, N. and Chen, W. and Dong, J. and Sawitzki, B. and Chung, H.R. and Rosenstiel, P. and Schulz, M.H. and Schultze, J.L. and Radbruch, A. and Walter, J. and Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M. and Saydaminova, K. and Yumul, R. and Krishnan, R. and Liu, J. and Nagy, E.E. and Singh, M. and Izsvák, Z. and Cattaneo, R. and Uckert, W. and Palmer, D. and Ng, P. and Haworth, K.G. and Kiem, H.P. and Ehrhardt, A. and Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch.
Kaplan, O.I. and Berber, B. and Hekim, N. and Doluca, O.
Nucleic Acids Research 44 (19): 9083-9095. 2 November 2016

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
Noel, J.K. and Whitford, P.C.
Nature Communications 7 : 13314. 31 October 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E. and Sin, C. and Zauber, H. and Wells, J.N. and Donnelly, N. and Wang, X. and Hou, J. and Chen, W. and Storchova, Z. and Marsh, J.A. and Valleriani, A. and Selbach, M.
Cell 167 (3): 803-815. 20 October 2016

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
Textor, A. and Schmidt, K. and Kloetzel, P.M. and Weißbrich, B. and Perez, C. and Charo, J. and Anders, K. and Sidney, J. and Sette, A. and Schumacher, T.N.M. and Keller, C. and Busch, D.H. and Seifert, U. and Blankenstein, T.
Journal of Experimental Medicine 213 (11): 2333-2348. 17 October 2016

Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice.
Viola, J.R. and Lemnitzer, P. and Jansen, Y. and Csaba, G. and Winter, C. and Neideck, C. and Silvestre-Roig, C. and Dittmar, G. and Doering, Y. and Drechsler, M. and Weber, C. and Zimmer, R. and Cenac, N. and Soehnlein, O.
Circulation Research 119 (9): 1030-1038. 14 October 2016

Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke, M. and Ibrahim, D.M. and Andrey, G. and Schwarzer, W. and Heinrich, V. and Schoepflin, R. and Kraft, K. and Kempfer, R. and Jerkovic, I. and Chan, W.L. and Spielmann, M. and Timmermann, B. and Wittler, L. and Kurth, I. and Cambiaso, P. and Zuffardi, O. and Houge, G. and Lambie, L. and Brancati, F. and Pombo, A. and Vingron, M. and Spitz, F. and Mundlos, S.
Nature 538 (7624): 265-269. 13 October 2016

Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R. and Fast, E.M. and Solaimani, P. and Knezevic, K. and Eliades, A. and Patel, R. and Thambyrajah, R. and Unnikrishnan, A. and Thoms, J. and Beck, D. and Vink, C.S. and Smith, A. and Wong, J. and Shepherd, M. and Kent, D. and Roychoudhuri, R. and Paul, F. and Klippert, J. and Hammes, A. and Willnow, T. and Göttgens, B. and Dzierzak, E. and Zon, L.I. and Lacaud, G. and Kouskoff, V. and Pimanda, J.E.
Blood 128 (15): 1928-1939. 13 October 2016

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
Ferone, G. and Song, J.Y. and Sutherland, K.D. and Bhaskaran, R. and Monkhorst, K. and Lambooij, J.P. and Proost, N. and Gargiulo, G. and Berns, A.
Cancer Cell 30 (4): 519-532. 10 October 2016

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
Kandalla, P.K. and Sarrazin, S. and Molawi, K. and Berruyer, C. and Redelberger, D. and Favel, A. and Bordi, C. and de Bentzmann, S. and Sieweke, M.H.
Journal of Experimental Medicine 213 (11): 2269-2279. 10 October 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Mueller, R. and Heinemann, U. and Kaupp, M. and Wahl, M. and Risse, T.
Journal of the American Chemical Society 138 (39): 12868-12875. 5 October 2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S. and Kohl, T. and Williams, G.S.B. and Gusev, K. and Wagner, E. and Rog-Zielinska, E.A. and Hebisch, E. and Dura, M. and Didié, M. and Gotthardt, M. and Nikolaev, V.O. and Hasenfuss, G. and Kohl, P. and Ward, C.W. and Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye, J. and Wenke, N.K. and Chayka, M. and Leubner, J. and Murugan, R. and Maier, N. and Jurek, B. and Ly, L.T. and Brandl, D. and Rost, B.R. and Stumpf, A. and Schulz, P. and Radbruch, H. and Hauser, A.E. and Pache, F. and Meisel, A. and Harms, L. and Paul, F. and Dirnagl, U. and Garner, C. and Schmitz, D. and Wardemann, H. and Prüss, H.
Brain 139 (10): 2641-2652. 1 October 2016

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J. and Yu, Y. and Akilli Öztürk, Ö. and Holland, J.D. and Besser, D. and Fritzmann, J. and Wulf-Goldenberg, A. and Eckert, K. and Fichtner, I. and Birchmeier, W.
Gut 65 (10): 1690-1701. October 2016

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos, K. and Gatsiou, A. and Stamatelopoulos, K. and Perisic Matic, L. and John, D. and Lunella, F.F. and Jae, N. and Rossbach, O. and Amrhein, C. and Sigala, F. and Boon, R.A. and Fuertig, B. and Manavski, Y. and You, X. and Uchida, S. and Keller, T. and Boeckel, J.N. and Franco-Cereceda, A. and Maegdefessel, L. and Chen, W. and Schwalbe, H. and Bindereif, A. and Eriksson, P. and Hedin, U. and Zeiher, A.M. and Dimmeler, S.
Nature Medicine 22 (10): 1140-1150. October 2016

Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
Roux, S. and Brum, J.R. and Dutilh, B.E. and Sunagawa, S. and Duhaime, M.B. and Loy, A. and Poulos, B.T. and Solonenko, N. and Lara, E. and Poulain, J. and Pesant, S. and Kandels-Lewis, S. and Dimier, C. and Picheral, M. and Searson, S. and Cruaud, C. and Alberti, A. and Duarte, C.M. and Gasol, J.M. and Vaque, D. and Bork, P. and Acinas, S.G. and Wincker, P. and Sullivan, M.B.
Nature 537 (7622): 689-693. 29 September 2016

52 genetic loci influencing myocardial mass.
van der Harst, P. and van Setten, J. and Verweij, N. and Vogler, G. and Franke, L. and Maurano, M.T. and Wang, X. and Mateo Leach, I. and Eijgelsheim, M. and Sotoodehnia, N. and Hayward, C. and Sorice, R. and Meirelles, O. and Lyytikaeinen, L.P. and Polašek, O. and Tanaka, T. and Arking, D.E. and Ulivi, S. and Trompet, S. and Mueller-Nurasyid, M. and Smith, A.V. and Dörr, M. and Kerr, K.F. and Magnani, J.W. and Del Greco, M.F. and Zhang, W. and Nolte, I.M. and Silva, C.T. and Padmanabhan, S. and Tragante, V. and Esko, T. and Abecasis, G.R. and Adriaens, M.E. and Andersen, K. and Barnett, P. and Bis, J.C. and Bodmer, R. and Buckley, B.M. and Campbell, H. and Cannon, M.V. and Chakravarti, A. and Chen, L.Y. and Delitala, A. and Devereux, R.B. and Doevendans, P.A. and Dominiczak, A.F. and Ferrucci, L. and Ford, I. and Gieger, C. and Harris, T.B. and Haugen, E. and Heinig, M. and Hernandez, D.G. and Hillege, H.L. and Hirschhorn, J.N. and Hofman, A. and Hubner, N. and Hwang, S.J. and Iorio, A. and Kaehoenen, M. and Kellis, M. and Kolcic, I. and Kooner, Is.K. and Kooner, J.S. and Kors, J.A. and Lakatta, E.G. and Lage, K. and Launer, L.J. and Levy, D. and Lundby, A. and Macfarlane, P.W. and May, D. and Meitinger, T. and Metspalu, A. and Nappo, S. and Naitza, S. and Neph, S. and Nord, A.S. and Nutile, T. and Okin, P.M. and Olsen, J.V. and Oostra, B.A. and Penninger, J.M. and Pennacchio, L.A. and Pers, T.H. and Perz, S. and Peters, A. and Pinto, Y.M. and Pfeufer, A. and Pilia, M.G. and Pramstaller, P.P. and Prins, B.P. and Raitakari, O.T. and Raychaudhuri, S. and Rice, K.M. and Rossin, E.J. and Rotter, J.I. and Schaefer, S. and Schlessinger, D. and Schmidt, C.O. and Sehmi, J. and Sillje, H.H.W. and Sinagra, G. and Sinner, M.F. and Slowikowski, K. and Soliman, E.Z. and Spector, T.D. and Spiering, W. and Stamatoyannopoulos, J.A. and Stolk, R.P. and Strauch, K. and Tan, S.T. and Tarasov, K.V. and Trinh, B. and Uitterlinden, A.G. and van den Boogaard, M. and van Duijn, C.M. and van Gilst, W.H. and Viikari, J.S. and Visscher, P.M. and Vitart, V. and Völker, U. and Waldenberger, M. and Weichenberger, C.X. and Westra, H.J. and Wijmenga, C. and Wolffenbuttel, B.H. and Yang, J. and Bezzina, C.R. and Munroe, P.B. and Snieder, H. and Wright, A.F. and Rudan, I. and Boyer, L.A. and Asselbergs, F.W. and van Veldhuisen, D.J. and Stricker, B.H. and Psaty, B.M. and Ciullo, M. and Sanna, S. and Lehtimäki, T. and Wilson, J.F. and Bandinelli, S. and Alonso, A. and Gasparini, P. and Jukema, J.W. and Kääb, S. and Gudnason, V. and Felix, S.B. and Heckbert, S.R. and de Boer, R.A. and Newton-Cheh, C. and Hicks, A.A. and Chambers, J.C. and Jamshidi, Y. and Visel, A. and Christoffels, V.M. and Isaacs, A. and Samani, N.J. and de Bakker, P.I.W.
Journal of the American College of Cardiology 68 (13): 1435-1448. 27 September 2016

Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
Weber, A. and Cohen, I. and Popp, O. and Dittmar, G. and Reiss, Y. and Sommer, T. and Ravid, T. and Jarosch, E.
Molecular Cell 63 (5): 827-839. 1 September 2016

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
Roest, H.L. and Sachsenberg, T. and Aiche, S. and Bielow, C. and Weisser, H. and Aicheler, F. and Andreotti, S. and Ehrlich, H.C. and Gutenbrunner, P. and Kenar, E. and Liang, X. and Nahnsen, S. and Nilse, L. and Pfeuffer, J. and Rosenberger, G. and Rurik, M. and Schmitt, U. and Veit, J. and Walzer, M. and Wojnar, D. and Wolski, W.E. and Schilling, O. and Choudhary, J.S. and Malmstroem, L. and Aebersold, R. and Reinert, K. and Kohlbacher, O.
Nature Methods 13 (9): 741-748. September 2016

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.
Sarnowski, C. and Laprise, C. and Malerba, G. and Moffatt, M.F. and Dizier, M.H. and Morin, A. and Vincent, Q.B. and Rohde, K. and Esparza-Gordillo, J. and Margaritte-Jeannin, P. and Liang, L. and Lee, Y.A. and Bousquet, J. and Siroux, V. and Pignatti, P.F. and Cookson, W.O. and Lathrop, M. and Pastinen, T. and Demenais, F. and Bouzigon, E.
Journal of Allergy and Clinical Immunology 138 (3): 748-753. September 2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O. and Winter, D.R. and Giladi, A. and Vargas Aguilar, S. and Spinrad, A. and Sarrazin, S. and Ben-Yehuda, H. and David, E. and Zelada González, F. and Perrin, P. and Keren-Shaul, H. and Gury, M. and Lara-Astaiso, D. and Thaiss, C.A. and Cohen, M. and Bahar Halpern, K. and Baruch, K. and Deczkowska, A. and Lorenzo-Vivas, E. and Itzkovitz, S. and Elinav, E. and Sieweke, M.H. and Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
Simandi, Z. and Horvath, A. and Wright, L.C. and Cuaranta-Monroy, I. and De Luca, I. and Karolyi, K. and Sauer, S. and Deleuze, J.F. and Gudas, L.J. and Cowley, S.M. and Nagy, L.
Molecular Cell 63 (4): 647-661. 18 August 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S. and Helmuth, J. and Polansky, J.K. and Dunkel, I. and Gasparoni, G. and Froehler, S. and Chen, W. and Walter, J. and Hamann, A. and Chung, H.R.
Nature Communications 7 : 12514. 17 August 2016

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.
Le, H.Q. and Ghatak, S. and Yeung, C.Y.C. and Tellkamp, F. and Günschmann, C. and Dieterich, C. and Yeroslaviz, A. and Habermann, B. and Pombo, A. and Niessen, C.M. and Wickström, S.A.
Nature Cell Biology 18 (8): 864-875. August 2016

Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
Kang, Y. and Gohlke, U. and Engström, O. and Hamark, C. and Scheidt, T. and Kunstmann, S. and Heinemann, U. and Widmalm, G. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 138 (29): 9109-9118. 27 July 2016

Human gut microbes impact host serum metabolome and insulin sensitivity.
Pedersen, H.K. and Gudmundsdottir, V. and Nielsen, H.B. and Hyotylainen, T. and Nielsen, T. and Jensen, B.A.H. and Forslund, K. and Hildebrand, F. and Prifti, E. and Falony, G. and Le Chatelier, E. and Levenez, F. and Doré, J. and Mattila, I. and Plichta, D.R. and Pöhö, P. and Hellgren, L.I. and Arumugam, M. and Sunagawa, S. and Vieira-Silva, S. and Jørgensen, T. and Holm, J.B. and Trošt, K. and Kristiansen, K. and Brix, S. and Raes, J. and Wang, J. and Hansen, T. and Bork, P. and Brunak, S. and Oresic, M. and Ehrlich, S.D. and Pedersen, O.
Nature 535 (7612): 376-381. 21 July 2016

Glycolytic regulation of cell rearrangement in angiogenesis.
Cruys, B. and Wong, B.W. and Kuchnio, A. and Verdegem, D. and Cantelmo, A. R. and Conradi, L.C. and Vandekeere, S. and Bouché, A. and Cornelissen, I. and Vinckier, S. and Merks, R.M.H. and Dejana, E. and Gerhardt, H. and Dewerchin, M. and Bentley, K. and Carmeliet, P.
Nature Communications 7 : 12240. 20 July 2016

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Gödde, K. and Gschwend, O. and Puchkov, D. and Pfeffer, C.K. and Carleton, A. and Jentsch, T.J.
Nature Communications 7 : 12043. 8 July 2016

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.
Letunic, I. and Bork, P.
Nucleic Acids Research 44 (W1): W242-W245. 8 July 2016

Wars2 is a determinant of angiogenesis.
Wang, M. and Sips, P. and Khin, E. and Rotival, M. and Sun, X. and Ahmed, R. and Widjaja, A.A. and Schafer, S. and Yusoff, P. and Choksi, Pe.K. and Ko, N.S.J. and Singh, M.K. and Epstein, D. and Guan, Y. and Houštěk, J. and Mracek, T. and Nuskova, H. and Mikell, B. and Tan, J. and Pesce, F. and Kolar, F. and Bottolo, L. and Mancini, M. and Hubner, N. and Pravenec, M. and Petretto, E. and MacRae, C. and Cook, S.A.
Nature Communications 7 : 12061. 8 July 2016

The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway.
Hasler, D. and Lehmann, G. and Murakawa, Y. and Klironomos, F. and Jakob, L. and Grässer, F.A. and Rajewsky, N. and Landthaler, M. and Meister, G.
Molecular Cell 63 (1): 110-124. 7 July 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V. and Schulz, N. and Yan, X. and Schürmann, A. and Kempa, S. and Kern, M. and Blüher, M. and Poy, M.N. and Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

The mRNA-bound proteome of the early fly embryo.
Wessels, H.H. and Imami, K. and Baltz, A.G. and Kolinski, M. and Beldovskaya, A. and Selbach, M. and Small, S. and Ohler, U. and Landthaler, M.
Genome Research 26 (7): 1000-1009. July 2016

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Van Haute, L. and Dietmann, S. and Kremer, L. and Hussain, S. and Pearce, S.F. and Powell, C.A. and Rorbach, J. and Lantaff, R. and Blanco, S. and Sauer, S. and Kotzaeridou, U. and Hoffmann, G.F. and Memari, Y. and Kolb-Kokocinski, A. and Durbin, R. and Mayr, J.A. and Frye, M. and Prokisch, H. and Minczuk, M.
Nature Communications 7 : 12039. 30 June 2016

CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L. and Haase, N. and Golic, M. and Rugor, J. and Solano, M.E. and Arck, P.C. and Gauster, M. and Huppertz, B. and Emontzpohl, C. and Stoppe, C. and Bernhagen, J. and Leng, L. and Bucala, R. and Schulz, H. and Heuser, A. and Weedon-Fekjær, S. and Johnsen, G.M. and Peetz, D. and Luft, F.C. and Staff, A.C. and Müller, D.N. and Dechend, R. and Herse, F.
Circulation Research 119 (1): 55-68. 24 June 2016

The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation.
von Delbrück, M. and Kniss, A. and Rogov, V.V. and Pluska, L. and Bagola, K. and Löhr, F. and Güntert, P. and Sommer, T. and Dötsch, V.
Molecular Cell 62 (6): 918-928. 16 June 2016

B cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B cell lymphoma in mice.
Knittel, G. and Liedgens, P. and Korovkina, D. and Seeger, J.M. and Al-Baldawi, Y. and Al-Maarri, M. and Fritz, C. and Vlantis, K. and Bezhanova, S. and Scheel, A.H. and Wolz, O.O. and Reimann, M. and Möller, P. and López, C. and Schlesner, M. and Lohneis, P. and Weber, A.N.R. and Trümper, L. and Staudt, L.M. and Ortmann, M. and Pasparakis, M. and Siebert, R. and Schmitt, C.A. and Klatt, A.R. and Wunderlich, F.T. and Schäfer, S.C. and Persigehl, T. and Montesinos-Rongen, M. and Odenthal, M. and Büttner, R. and Frenzel, L.P. and Kashkar, H. and Reinhardt, H.C.
Blood 127 (22): 2732-2741. 2 June 2016

Phase II trial of temsirolimus for relapsed/refractory primary CNS lymphoma.
Korfel, A. and Schlegel, U. and Herrlinger, U. and Dreyling, M. and Schmidt, C. and von Baumgarten, L. and Pezzutto, A. and Grobosch, T. and Kebir, S. and Thiel, E. and Martus, P. and Kiewe, P.
Journal of Clinical Oncology 34 (15): 1757-1763. 20 May 2016

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus.
Stempel, A.V. and Stumpf, A. and Zhang, H.Y. and Özdoğan, T. and Pannasch, U. and Theis, A.K. and Otte, D.M. and Wojtalla, A. and Racz, I. and Ponomarenko, A. and Xi, Z.X. and Zimmer, A. and Schmitz, D.
Neuron 90 (4): 795-809. 18 May 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. and Hilgenberg, E. and Stervbo, U. and Lampropoulou, V. and Shen, P. and Bunse, M. and Jaimes, Y. and Boudinot, P. and Radbruch, A. and Klemm, U. and Kühl, A.A. and Liblau, R. and Hoevelmeyer, N. and Anderton, S.M. and Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

Standardized benchmarking in the quest for orthologs.
Altenhoff, A.M. and Boeckmann, B. and Capella-Gutierrez, S. and Dalquen, D.A. and DeLuca, T. and Forslund, K. and Huerta-Cepas, J. and Linard, B. and Pereira, C. and Pryszcz, L.P. and Schreiber, F. and da Silva, A.S. and Szklarczyk, D. and Train, C.M. and Bork, P. and Lecompte, O. and von Mering, C. and Xenarios, I. and Sjölander, K. and Jensen, L.J. and Martin, M.J. and Muffato, M. and Gabaldón, T. and Lewis, S.E. and Thomas, P.D. and Sonnhammer, E. and Dessimoz, C.
Nature Methods 13 (5): 425-430. May 2016

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
Bartus, K. and Galino, J. and James, N.D. and Hernandez-Miranda, L.R. and Dawes, J.M. and Fricker, F.R. and Garratt, A.N. and McMahon, S.B. and Ramer, M.S. and Birchmeier, C. and Bennett, D.L.H. and Bradbury, E.J.
Brain 139 (Pt 5): 1394-1416. May 2016

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li, S.S. and Zhu, A. and Benes, V. and Costea, P.I. and Hercog, R. and Hildebrand, F. and Huerta-Cepas, J. and Nieuwdorp, M. and Salojaervi, J. and Voigt, A.Y. and Zeller, G. and Sunagawa, S. and de Vos, W.M. and Bork, P.
Science 352 (6285): 586-589. 29 April 2016

Plankton networks driving carbon export in the oligotrophic ocean.
Guidi, L. and Chaffron, S. and Bittner, L. and Eveillard, D. and Larhlimi, A. and Roux, S. and Darzi, Y. and Audic, S. and Berline, L. and Brum, J. and Coelho, L.P. and Espinoza, J.C.I. and Malviya, S. and Sunagawa, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Poulain, J. and Searson, S. and Stemmann, L. and Not, F. and Hingamp, P. and Speich, S. and Follows, M. and Karp-Boss, L. and Boss, E. and Ogata, H. and Pesant, S. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Bork, P. and de Vargas, C. and Iudicone, D. and Sullivan, M.B. and Raes, J. and Karsenti, E. and Bowler, C. and Gorsky, G.
Nature 532 (7600): 465-470. 28 April 2016

Energy efficiency trade-offs drive nucleotide usage in transcribed regions.
Chen, W.H. and Lu, G. and Bork, P. and Hu, S. and Lercher, M.J.
Nature Communications 7 : 11334. 21 April 2016

4D visualization of replication foci in mammalian cells corresponding to individual replicons.
Chagin, V.O. and Casas-Delucchi, C.S. and Reinhart, M. and Schermelleh, L. and Markaki, Y. and Maiser, A. and Bolius, J.J. and Bensimon, A. and Fillies, M. and Domaing, P. and Rozanov, Y.M. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 7 : 11231. 7 April 2016

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Gebala, V. and Collins, R. and Geudens, I. and Phng, L.K. and Gerhardt, H.
Nature Cell Biology 18 (4): 443-450. April 2016

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F. and Wiedemann, L. and Zuliani, C. and Querques, I. and Sebe, A. and Mátés, L. and Izsvák, Z. and Ivics, Z. and Barabas, O.
Nature Communications 7 : 11126. 30 March 2016

Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton.
Cornejo-Castillo, F.M. and Cabello, A.M. and Salazar, G. and Sanchez-Baracaldo, P. and Lima-Mendez, G. and Hingamp, P. and Alberti, A. and Sunagawa, S. and Bork, P. and de Vargas, C. and Raes, J. and Bowler, C. and Wincker, P. and Zehr, J.P. and Gasol, J.M. and Massana, R. and Acinas, S.G.
Nature Communications 7 : 11071. 22 March 2016

Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori, A. and Iskar, M. and Buczak, K. and Kastritis, P. and Parca, L. and Andres-Pons, A. and Singer, S. and Bork, P. and Beck, M.
Genome Biology 17 (1): 47. 14 March 2016

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I. and Messing, S.A. and Thomas, J. and Cosby, R.L. and Bilic, I. and Miskey, C. and Gogol-Döring, A. and Kapitonov, V. and Diem, T. and Dalda, A. and Jurka, J. and Pritham, E.J. and Dyda, F. and Izsvák, Z. and Ivics, Z.
Nature Communications 7 : 10716. 2 March 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. and Kammertoens, T. and Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

Integration of multi-omics data of a genome-reduced bacterium: prevalence of post-transcriptional regulation and its correlation with protein abundances.
Chen, W.H. and van Noort, V. and Lluch-Senar, M. and Hennrich, M.L. and Wodke, J.A.H. and Yus, E. and Alibes, A. and Roma, G. and Mende, D.R. and Pesavento, C. and Typas, A. and Gavin, A.C. and Serrano, L. and Bork, P.
Nucleic Acids Research 44 (3): 1192-1202. 18 February 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L. and Weng, Z. and Geirsdóttir, L. and Molawi, K. and Maurizio, J. and Fenouil, R. and Mossadegh-Keller, N. and Gimenez, G. and VanHille, L. and Beniazza, M. and Favret, J. and Berruyer, C. and Perrin, P. and Hacohen, N. and Andrau, J.C. and Ferrier, P. and Dubreuil, P. and Sidow, A. and Sieweke, M.H.
Science 351 (6274): aad5510. 12 February 2016

miR-23~27~24 clusters control effector T cell differentiation and function.
Cho, S. and Wu, C.J. and Yasuda, T. and Cruz, L.O. and Khan, A.A. and Lin, L.L. and Nguyen, D.T. and Miller, M. and Lee, H.M. and Kuo, M.L. and Broide, D.H. and Rajewsky, K. and Rudensky, A.Y. and Lu, L.F.
Journal of Experimental Medicine 213 (2): 235-249. 8 February 2016

Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
Grandin, M. and Meier, M. and Delcros, J.G. and Nikodemus, D. and Reuten, R. and Patel, T.R. and Goldschneider, D. and Orriss, G. and Krahn, N. and Boussouar, A. and Abes, R. and Dean, Y. and Neves, D. and Bernet, A. and Depil, S. and Schneiders, F. and Poole, K. and Dante, R. and Koch, M. and Mehlen, P. and Stetefeld, J.
Cancer Cell 29 (2): 173-185. 8 February 2016

Genome-wide polyadenylation maps reveal dynamic mRNA 3'-end formation in the failing human heart.
Creemers, E.E. and Bawazeer, A. and Ugalde, A.P. and van Deutekom, H.W.M. and van der Made, I. and de Groot, N.E. and Adriaens, M.E. and Cook, S.A. and Bezzina, C.R. and Hubner, N. and van der Velden, J. and Elkon, R. and Agami, R. and Pinto, Y.M.
Circulation Research 118 (3): 433-438. 5 February 2016

Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L. and Mukherjee, N. and Wyler, E. and Zauber, H. and Hirsekorn, A. and Selbach, M. and Landthaler, M. and Obermayer, B. and Ohler, U.
Nature Methods 13 (2): 165-170. February 2016

Immunological memory: lessons from the past and a look to the future.
Farber, D.L. and Netea, M.G. and Radbruch, A. and Rajewsky, K. and Zinkernagel, R.M.
Nature Reviews Immunology 16 (2): 124-128. February 2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. and Singh, M. and Sun, C. and Besser, D. and Prigione, A. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature Protocols 11 (2): 327-346. February 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K. and Happel, K. and Eelen, G. and Schoors, S. and Oellerich, M.F. and Lim, R. and Zimmermann, B. and Aspalter, I.M. and Franco, C.A. and Boettger, T. and Braun, T. and Fruttiger, M. and Rajewsky, K. and Keller, C. and Brüning, J.C. and Gerhardt, H. and Carmeliet, P. and Potente, M.
Nature 529 (7585): 216-220. 14 January 2016

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S. and Fuchs, N.V. and Upton, K.R. and Muñoz-Lopez, M. and Shukla, R. and Wang, J. and Garcia-Cañadas, M. and Lopez-Ruiz, C. and Gerhardt, D.J. and Sebe, A. and Grabundzija, I. and Merkert, S. and Gerdes, P. and Pulgarin, J.A. and Bock, A. and Held, U. and Witthuhn, A. and Haase, A. and Sarkadi, B. and Löwer, J. and Wolvetang, E.J. and Martin, U. and Ivics, Z. and Izsvák, Z. and Garcia-Perez, J.L. and Faulkner, G.J. and Schumann, G.G.
Nature Communications 7 : 10286. 8 January 2016

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Huerta-Cepas, J. and Szklarczyk, D. and Forslund, K. and Cook, H. and Heller, D. and Walter, M.C. and Rattei, T. and Mende, D.R. and Sunagawa, S. and Kuhn, M. and Jensen, L.J. and von Mering, C. and Bork, P.
Nucleic Acids Research 44 (D1): D286-D293. 4 January 2016

The SIDER database of drugs and side effects.
Kuhn, M. and Letunic, I. and Jensen, L.J. and Bork, P.
Nucleic Acids Research 44 (D1): D1075-D1079. 4 January 2016

STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.
Szklarczyk, D. and Santos, A. and von Mering, C. and Jensen, L.J. and Bork, P. and Kuhn, M.
Nucleic Acids Research 44 (D1): D380-D384. 4 January 2016

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H. and Haas, S.A. and Chelly, J. and Van Esch, H. and Raynaud, M. and de Brouwer, A.P.M. and Weinert, S. and Froyen, G. and Frints, S.G.M. and Laumonnier, F. and Zemojtel, T. and Love, M.I. and Richard, H. and Emde, A.K. and Bienek, M. and Jensen, C. and Hambrock, M. and Fischer, U. and Langnick, C. and Feldkamp, M. and Wissink-Lindhout, W. and Lebrun, N. and Castelnau, L. and Rucci, J. and Montjean, R. and Dorseuil, O. and Billuart, P. and Stuhlmann, T. and Shaw, M. and Corbett, M.A. and Gardner, A. and Willis-Owen, S. and Tan, C. and Friend, K.L. and Belet, S. and van Roozendaal, K.E.P. and Jimenez-Pocquet, M. and Moizard, M.P. and Ronce, N. and Sun, R. and O'Keeffe, S. and Chenna, R. and van Bömmel, A. and Goeke, J. and Hackett, A. and Field, M. and Christie, L. and Boyle, J. and Haan, E. and Nelson, J. and Turner, G. and Baynam, G. and Gillessen-Kaesbach, G. and Mueller, U. and Steinberger, D. and Budny, B. and Badura-Stronka, M. and Latos-Bieleńska, A. and Ousager, L.B. and Wieacker, P. and Rodríguez Criado, G. and Bondeson, M.L. and Annerén, G. and Dufke, A. and Cohen, M. and Van Maldergem, L. and Vincent-Delorme, C. and Echenne, B. and Simon-Bouy, B. and Kleefstra, T. and Willemsen, M. and Fryns, J.P. and Devriendt, K. and Ullmann, R. and Vingron, M. and Wrogemann, K. and Wienker, T.F. and Tzschach, A. and van Bokhoven, H. and Gecz, J. and Jentsch, T.J. and Chen, W. and Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21 (1): 133-148. January 2016

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
Schmitt, J. and Schwarz, K. and Baurecht, H. and Hotze, M. and Fölster-Holst, R. and Rodríguez, E. and Lee, Y.A.E. and Franke, A. and Degenhardt, F. and Lieb, W. and Gieger, C. and Kabesch, M. and Nöthen, M.M. and Irvine, A.D. and McLean, W.H.I. and Deckert, S. and Stephan, V. and Schwarz, P. and Aringer, M. and Novak, N. and Weidinger, S.
Journal of Allergy and Clinical Immunology 137 (1): 130-136. January 2016

The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
Silva, C.R. and Oliveira, S.M. and Hoffmeister, C. and Funck, V. and Guerra, G.P. and Trevisan, G. and Tonello, R. and Rossato, M.F. and Pesquero, J.B. and Bader, M. and Oliveira, M.S. and McDougall, J.J. and Ferreira, J.
Annals of the Rheumatic Diseases 75 (1): 260-268. January 2016

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.
Fraser, J. and Ferrai, C. and Chiariello, A.M. and Schueler, M. and Rito, T. and Laudanno, G. and Barbieri, M. and Moore, B.L. and Kraemer, D.C.A. and Aitken, S. and Xie, S.Q. and Morris, K.J. and Itoh, M. and Kawaji, H. and Jaeger, I. and Hayashizaki, Y. and Carninci, P. and Forrest, A.R.R. and Semple, C.A. and Dostie, J. and Pombo, A. and Nicodemi, M.
Molecular Systems Biology 11 (12): 852. 23 December 2015

PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S. and Chu, V.T. and Yasuda, T. and Franklin, A. and Graf, R. and Calado, D.P. and Li, S. and Imami, K. and Selbach, M. and Di Virgilio, M. and Bullinger, L. and Rajewsky, K.
Immunity 43 (6): 1075-1086. 15 December 2015

A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer.
von Eyss, B. and Jaenicke, L.A. and Kortlever, R.M. and Royla, N. and Wiese, K.E. and Letschert, S. and McDuffus, L.A. and Sauer, M. and Rosenwald, A. and Evan, G.I. and Kempa, S. and Eilers, M.
Cancer Cell 28 (6): 743-757. 14 December 2015

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K. and Hildebrandt, F. and Nielsen, T. and Falony, G. and Le Chatelier, E. and Sunagawa, S. and Prifti, E. and Vieira-Silva, S. and Gudmundsdottir, V. and Pedersen, H.K. and Arumugam, M. and Kristiansen, K. and Voigt, A.Y. and Vestergaard, H. and Hercog, R. and Costea, P.I. and Kultima, J.R. and Li, J. and Jørgensen, T. and Levenez, F. and Dore, J. and Nielsen, H.B. and Brunak, S. and Raes, J. and Hansen, T. and Wang, J. and Ehrlich, S.D. and Bork, P. and Pedersen, O.
Nature 528 (7581): 262-266. 10 December 2015

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Finkin, S. and Yuan, D. and Stein, I. and Taniguchi, K. and Weber, A. and Unger, K. and Browning, J.L. and Goossens, N. and Nakagawa, S. and Gunasekaran, G. and Schwartz, M.E. and Kobayashi, M. and Kumada, H. and Berger, M. and Pappo, O. and Rajewsky, K. and Hoshida, Y. and Karin, M. and Heikenwalder, M. and Ben-Neriah, Y. and Pikarsky, E.
Nature Immunology 16 (12): 1235-1244. December 2015

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster, L. and Standl, M. and Waage, J. and Baurecht, H. and Hotze, M. and Strachan, D.P. and Curtin, J.A. and Bønnelykke, K. and Tian, C. and Takahashi, A. and Esparza-Gordillo, J. and Alves, A.C. and Thyssen, J.P. and den Dekker, H.T. and Ferreira, M.A. and Altmaier, E. and Sleiman, P.M.A. and Xiao, F.L. and Gonzalez, J.R. and Marenholz, I. and Kalb, B. and Pino-Yanes, M. and Xu, C.J. and Carstensen, L. and Groen-Blokhuis, M.M. and Venturini, C. and Pennell, C.E. and Barton, S.J. and Levin, A.M. and Curjuric, I. and Bustamante, M. and Kreiner-Møller, E. and Lockett, G.A. and Bacelis, J. and Bunyavanich, S. and Myers, R.A. and Matanovic, A. and Kumar, A. and Tung, J.Y. and Hirota, T. and Kubo, M. and McArdle, W.L. and Henderson, A.J. and Kemp, J.P. and Zheng, J. and Smith, G.D. and Rüschendorf, F. and Bauerfeind, A. and Lee-Kirsch, M.A. and Arnold, A. and Homuth, G. and Schmidt, C.O. and Mangold, E. and Cichon, S. and Keil, T. and Rodríguez, E. and Peters, A. and Franke, A. and Lieb, W. and Novak, N. and Fölster-Holst, R. and Horikoshi, M. and Pekkanen, J. and Sebert, S. and Husemoen, L.L. and Grarup, N. and de Jongste, J.C. and Rivadeneira, F. and Hofman, A. and Jaddoe, V.W.V. and Pasmans, S.G.M.A. and Elbert, N.J. and Uitterlinden, A.G. and Marks, G.B. and Thompson, P.J. and Matheson, M.C. and Robertson, C.F. and Ried, J.S. and Li, J. and Zuo, X.B. and Zheng, X.D. and Yin, X.Y. and Sun, L.D. and McAleer, M.A. and O'Regan, G.M. and Fahy, C.M.R. and Campbell, L.E. and Macek, M. and Kurek, M. and Hu, D. and Eng, C. and Postma, D.S. and Feenstra, B. and Geller, F. and Hottenga, J.J. and Middeldorp, C.M. and Hysi, P. and Bataille, V. and Spector, T. and Tiesler, C.M.T. and Thiering, E. and Pahukasahasram, B. and Yang, J.J. and Imboden, M. and Huntsman, S. and Vilor-Tejedor, N. and Relton, C.L. and Myhre, R. and Nystad, W. and Custovic, A. and Weiss, S.T. and Meyers, D.A. and Söderhäll, C. and Melén, E. and Ober, C. and Raby, B.A. and Simpson, A. and Jacobsson, B. and Holloway, J.W. and Bisgaard, H. and Sunyer, J. and Probst-Hensch, N.M. and Williams, L.K. and Godfrey, K.M. and Wang, C.A. and Boomsma, D.I. and Melbye, M. and Koppelman, G.H. and Jarvis, D. and McLean, W.H.I. and Irvine, A.D. and Zhang, X.J. and Hakonarson, H. and Gieger, C. and Burchard, E.G. and Martin, N.G. and Duijts, L. and Linneberg, A. and Jarvelin, M.R. and Noethen, M.M. and Lau, S. and Hübner, N. and Lee, Y.A. and Tamari, M. and Hinds, D.A. and Glass, D. and Brown, S.J. and Heinrich, J. and Evans, D.M. and Weidinger, S.
Nature Genetics 47 (12): 1449-1456. December 2015

Optogenetic acidification of synaptic vesicles and lysosomes.
Rost, B.R. and Schneider, F. and Grauel, M.K. and Wozny, C. and Bentz, C.G. and Blessing, A. and Rosenmund, T. and Jentsch, T.J. and Schmitz, D. and Hegemann, P. and Rosenmund, C.
Nature Neuroscience 18 (12): 1845-1852. December 2015

Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I. and Esparza-Gordillo, J. and Rüschendorf, F. and Bauerfeind, A. and Strachan, D.P. and Spycher, B.D. and Baurecht, H. and Margaritte-Jeannin, P. and Sääf, A. and Kerkhof, M. and Ege, M. and Baltic, S. and Matheson, M.C. and Li, J. and Michel, S. and Ang, W.Q. and McArdle, W. and Arnold, A. and Homuth, G. and Demenais, F. and Bouzigon, E. and Söderhäll, C. and Pershagen, G. and de Jongste, J.C. and Postma, D.S. and Braun-Fahrlaender, C. and Horak, E. and Ogorodova, L.M. and Puzyrev, V.P. and Bragina, E.Y. and Hudson, T.J. and Morin, C. and Duffy, D.L. and Marks, G.B. and Robertson, C.F. and Montgomery, G.W. and Musk, B. and Thompson, P.J. and Martin, N.G. and James, A. and Sleiman, P. and Toskala, E. and Rodriguez, E. and Fölster-Holst, R. and Franke, A. and Lieb, W. and Gieger, C. and Heinzmann, A. and Rietschel, E. and Keil, T. and Cichon, S. and Nöthen, M.M. and Pennell, C.E. and Sly, P.D. and Schmidt, C.O. and Matanovic, A. and Schneider, V. and Heinig, M. and Hübner, N. and Holt, P.G. and Lau, S. and Kabesch, M. and Weidinger, S. and Hakonarson, H. and Ferreira, M.A.R. and Laprise, C. and Freidin, M.B. and Genuneit, J. and Koppelman, G.H. and Melén, E. and Dizier, M.H. and Henderson, A.J. and Lee, Y.A.
Nature Communications 6 : 8804. 6 November 2015

Operon structure and cotranslational subunit association direct protein assembly in bacteria.
Shieh, Y.W. and Minguez, P. and Bork, P. and Auburger, J.J. and Guilbride, D.L. and Kramer, G. and Bukau, B.
Science 350 (6261): 678-680. 6 November 2015

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J. and Gebhardt, M. and Heinig, M. and Rintisch, C. and Schroeder, A. and Neuhofer, W. and Hilgers, K. and Manzel, A. and Schwartz, C. and Kleinewietfeld, M. and Voelkl, J. and Schatz, V. and Linker, R.A. and Lang, F. and Voehringer, D. and Wright, M.D. and Hubner, N. and Dechend, R. and Jantsch, J. and Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125 (11): 4223-4238. 2 November 2015

Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N. and Jae, N. and Heumueller, A.W. and Chen, W. and Boon, R.A. and Stellos, K. and Zeiher, A.M. and John, D. and Uchida, S. and Dimmeler, S.
Circulation Research 117 (10): 884-890. 23 October 2015

Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A. and Sozzani, R. and Yardımcı, G.G. and Petricka, J.J.<