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Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O., Kirchner, M., Mertins, P., Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57
(9): 2140-2156.e10.
10 September 2024
Cell swelling enhances ligand-driven β-adrenergic signaling.
Sirbu, A., Bathe-Peters, M., Kumar, J.L.M, Inoue, A., Lohse, M.J. and Annibale, P.
Nature Communications 15
(1): 7822.
7 September 2024
Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations.
Penter, L., Cieri, N., Maurer, K., Kwok, M., Lyu, H., Lu, W.S., Oliveira, G., Gohil, S.H., Leshchiner, I., Lareau, C.A., Ludwig, L.S., Neuberg, D.S., Kim, H.T., Li, S., Bullinger, L., Ritz, J., Getz, G., Garcia, J.S., Soiffer, R.J., Livak, K.J. and Wu, C.J.
Blood Cancer Discovery
5 September 2024
(In Press)
Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova, D., Fritsch, V.N., Siebert, K., Methling, K., Lalk, M., Busche, T., Kalinowski, J., Weiner, J., Beule, D., Bertrams, W., Kohler, T.P., Hammerschmidt, S., Löwa, A., Fischer, M., Mieth, M., Hellwig, K., Frey, D., Neudecker, J., Rueckert, J.C., Toennies, M., Bauer, T.T., Graff, M., Tran, H.L., Eggeling, S., Gruber, A.D., Antelmann, H., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal
: 2301983.
4 September 2024
(In Press)
The influence of MOGAD on diagnosis of multiple sclerosis using MRI.
Geraldes, R., Arrambide, G., Banwell, B., Rovira, À., Cortese, R., Lassmann, H., Messina, S., Rocca, M.A., Waters, P., Chard, D., Gasperini, C., Hacohen, Y., Mariano, R., Paul, F., DeLuca, G.C., Enzinger, C., Kappos, L., Leite, M.I., Sastre-Garriga, J., Yousry, T., Ciccarelli, O., Filippi, M., Barkhof, F. and Palace, J.
Nature Reviews Neurology
3 September 2024
(In Press)
Autoantigen-specific CD4(+) T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.S., Dargvainiene, J., Martini, G.R., Stürner, K.H., Schröder, I., Markewitz, R., Hartl, J., Hastermann, M., Duchow, A., Schindler, P., Becker, M., Bautista, C., Gottfreund, J., Walter, J., Polansky, J.K., Yang, M., Naghavian, R., Wendorff, M., Schuster, E.M., Dahl, A., Petzold, A., Reinhardt, S., Franke, A., Wieczorek, M., Henschel, L., Berger, D., Heine, G., Holtsche, M., Häußler, V., Peters, C., Schmidt, E., Fillatreau, S., Busch, D.H., Wandinger, K.P., Schober, K., Martin, R., Paul, F., Leypoldt, F. and Scheffold, A.
Immunity
2 September 2024
(In Press)
Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling.
Brauer, E., Herrera, A., Fritsche-Guenther, R., Görlitz, S., Leemhuis, H., Knaus, P., Kirwan, J.A., Duda, G.N. and Petersen, A.
Biomaterials 309
: 122614.
September 2024
Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications - a HARMONY study.
Hernández-Sánchez, A., González, T., Sobas, M., Sträng, E., Castellani, G., Abáigar, M., Valk, P.J.M., Villaverde Ramiro, Á., Benner, A., Metzeler, K.H., Azibeiro, R., Tettero, J.M., Martínez-López, J., Pratcorona, M., Martínez Elicegui, J., Mills, K.I., Thiede, C., Sanz, G., Döhner, K., Heuser, M., Haferlach, T., Turki, A.T., Reinhardt, D., Schulze-Rath, R., Barbus, M., Hernández-Rivas, J.M., Huntly, B., Ossenkoppele, G., Döhner, H. and Bullinger, L.
Leukemia 38
(9): 1929-1937.
September 2024
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T., Graf, R., Acevedo-Ochoa, E., Trombke, J., Weber, T., Sommermann, T., Salomon, C., Kühn, R., Rajewsky, K. and Chu, V.T.
Leukemia 38
(9): 2003-2015.
September 2024
A catalog of small proteins from the global microbiome.
Duan, Y., Santos-Júnior, C.D., Schmidt, T.S., Fullam, A., de Almeida, B.L.S., Zhu, C., Kuhn, M., Zhao, X.M., Bork, P. and Coelho, L.P.
Nature Communications 15
(1): 7563.
31 August 2024
Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135
(6): 671-684.
30 August 2024
Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study.
Derigs, P., Schubert, M.L., Dreger, P., Schmitt, A., Yousefian, S., Haas, S., Röthemeier, C., Neuber, B., Hückelhoven-Krauss, A., Brüggemann, M., Bernhard, H., Kobbe, G., Lindemann, A., Rummel, M., Michels, B., Korell, F., Ho, A.D., Müller-Tidow, C. and Schmitt, M.
Leukemia
27 August 2024
(In Press)
Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture.
Patsalos, A., Halasz, L., Oleksak, D., Wei, X., Nagy, G., Tzerpos, P., Conrad, T., Hammers, D.W., Sweeney, H.L. and Nagy, L.
Journal of Clinical Investigation
27 August 2024
(In Press)
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B.D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K.P.L., Flüh, C., Kälin, R.E. and Glass, R.
Cell Reports Medicine 5
(8): 101658.
20 August 2024
Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.
Halik, A., Tilgner, M., Silva, P., Estrada, N., Altwasser, R., Jahn, E., Heuser, M., Hou, H.A., Pratcorona, M., Hills, R.K., Metzeler, K.H., Fenwarth, L., Dolnik, A., Terre, C., Kopp, K., Blau, O., Szyska, M., Christen, F., Krönke, J., Vasseur, L., Löwenberg, B., Esteve, J., Valk, P.J.M., Duchmann, M., Chou, W.C., Linch, D.C., Döhner, H., Gale, R.E., Döhner, K., Bullinger, L., Yoshida, K. and Damm, F.
Journal of Hematology & Oncology 17
(1): 70.
19 August 2024
Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts.
Lai, S., Wang, H., Bork, P., Chen, W.H. and Zhao, X.M.
Science Advances 10
(33): eadn3316.
16 August 2024
Lysozyme 1 inflamed CCR2(+) macrophages promote obesity-induced cardiac dysfunction.
Zhang, L., Han, H., Xu, A., Sathe, A., Fu, S., Zhao, J., Cai, W., Yang, Y., Liu, J., Bai, H., Ben, J., Zhu, X., Li, X., Yang, Q., Wang, Z., Gu, Y., Xing, C., Schiattarella, G.G., Cheng, S.Y., Zhang, H. and Chen, Q.
Circulation Research 135
(5): 596-613.
16 August 2024
Amplification of autoimmune organ damage by NKp46-activated ILC1.
Biniaris-Georgallis, S.I., Aschman, T., Stergioula, K., Schreiber, F., Jafari, V., Taranko, A., Karmalkar, T., Kasapi, A., Lenac Rovis, T., Jelencic, V., Bejarano, D.A., Fabry, L., Papacharalampous, M., Mattiola, I., Molgora, M., Hou, J., Hublitz, K.W., Heinrich, F., Guerra, G.M., Durek, P., Patone, G., Lindberg, E.L.H., Maatz, H., Hölsken, O., Krönke, G., Mortha, A., Voll, R.E., Clarke, A.J., Hauser, A.E., Colonna, M., Thurley, K., Schlitzer, A., Schneider, C., Stamatiades, E.G., Mashreghi, M.F., Jonjic, S., Hübner, N., Diefenbach, A., Kanda, M. and Triantafyllopoulou, A.
Nature
13 August 2024
(In Press)
PITX2 deficiency leads to atrial mitochondrial dysfunction.
Reyat, J.S., Sommerfeld, L.C., O'Reilly, M., Cardoso, V.R., Thiemann, E., Khan, A.O., O'Shea, C., Harder, S., Müller, C., Barlow, J., Stapley, R.J., Chua, W., Kabir, S.N., Grech, O., Hummel, O., Hübner, N., Kääb, S., Mont, Ll., Hatem, S.N., Winters, J., Zeemering, S., Morgan, N.V., Rayes, J., Gehmlich, K., Stoll, M., Brand, T., Schweizer, M., Piasecki, A., Schotten, U., Gkoutos, G.V., Lorenz, K., Cuello, F., Kirchhof, P. and Fabritz, L.
Cardiovascular Research
: cvae169.
12 August 2024
(In Press)
Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15
(1): 6851.
10 August 2024
Hif-2α programmes oxygen chemosensitivity in chromaffin cells.
Prange-Barczynska, M., Jones, H.A., Sugimoto, Y., Cheng, X., Lima, J.D., Ratnayaka, I., Douglas, G., Buckler, K.J., Ratcliffe, P.J., Keeley, T.P. and Bishop, T.
Journal of Clinical Investigation
6 August 2024
(In Press)
Bifidobacterium and lactobacillus probiotics and gut dysbiosis in preterm infants: the PRIMAL randomized clinical trial.
Van Rossum, T., Haiß, A., Knoll, R.L., Marißen, J., Podlesny, D., Pagel, J., Bleskina, M., Vens, M., Fortmann, I., Siller, B., Ricklefs, I., Klopp, J., Hilbert, K., Meyer, C., Thielemann, R., Goedicke-Fritz, S., Kuntz, M., Wieg, C., Teig, N., Körner, T., Kribs, A., Hudalla, H., Knuf, M., Stein, A., Gille, C., Bagci, S., Dohle, F., Proquitté, H., Olbertz, D.M., Schmidt, E., Koch, L., Pirr, S., Rupp, J., Spiegler, J., Kopp, M.V., Göpel, W., Herting, E., Forslund, S.K., Viemann, D., Zemlin, M., Bork, P., Gehring, S., König, I.R., Henneke, P. and Härtel, C.
JAMA Pediatrics
5 August 2024
(In Press)
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Widjaja, A.A., Lim, W.W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C.M., Goh, J.W.T., Lim, R., Singh, B.K., Tan, J., Pua, C.J., Lim, S.Y., Adami, E., Schafer, S., George, B.L., Sweeney, M., Xie, C., Tripathi, M., Sims, N.A., Hübner, N., Petretto, E., Withers, D.J., Ho, L., Gil, J., Carling, D. and Cook, S.A.
Nature 632
(8023): 157-165.
1 August 2024
Likelihood of post-COVID condition in people with hybrid immunity; data from the German National Cohort (NAKO).
Mikolajczyk, R., Diexer, S., Klee, B., Pfrommer, L., Purschke, O., Fricke, J., Ahnert, P., Gabrysch, S., Gottschick, C., Bohn, B., Brenner, H., Buck, C., Castell, S., Gastell, S., Greiser, K.H., Harth, V., Heise, J.K., Holleczek, B., Kaaks, R., Keil, T., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, Cl., Michels, K.B., Moreno Velásquez, I., Obi, N., Panreck, L., Peters, A., Pischon, T., Schikowski, T., Schmidt, B., Standl, M., Stang, A., Völzke, H., Weber, A., Zeeb, H. and Karch, A.
Journal of Infection 89
(2): 106206.
August 2024
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E., Lauber, C., Manukyan, A., Deter, A., Quedenau, C., Teixeira Alves, L.G., Wylezich, C., Borodina, T., Seitz, S., Altmüller, J. and Landthaler, M.
Environment International 190
: 108875.
August 2024
Association of adverse clinical outcomes with peri-infarct ischemia detected by stress cardiac magnetic imaging.
Bernhard, B., Ge, Y., Antiochos, P., Heydari, B., Islam, S., Sanchez Santiuste, N., Steel, K.E., Bingham, S., Mikolich, J.R., Arai, A.E., Bandettini, W.P., Patel, A.R., Shanbhag, S.M., Farzaneh-Far, A., Heitner, J.F., Shenoy, C., Leung, S.W., Gonzalez, J.A., Raman, S.V., Ferrari, V.A., Shah, D.J., Schulz-Menger, J., Stuber, M., Simonetti, O.P. and Kwong, R.Y.
Journal of the American College of Cardiology 84
(5): 417-429.
30 July 2024
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts.
Kolesnichenko, M. and Scheidereit, C.
Signal Transduction and Targeted Therapy 9
(1): 179.
29 July 2024
Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial.
Borchmann, P., Ferdinandus, J., Schneider, G., Moccia, A., Greil, R., Hertzberg, M., Schaub, V., Hüttmann, A., Keil, F., Dierlamm, J., Hänel, M., Novak, U., Meissner, J., Zimmermann, A., Mathas, S., Zijlstra, J.M., Fosså, A., Viardot, A., Hertenstein, B., Martin, S., Giri, P., Scholl, S., Topp, M.S., Jung, W., Vucinic, V., Beck, H.J., Kerkhoff, A., Unger, B., Rank, A., Schroers, R., zum Büschenfelde, C.M., de Wit, M., Trautmann-Grill, K., Kamper, P., Molin, D., Kreissl, S., Kaul, H., von Tresckow, B., Borchmann, S., Behringer, K., Fuchs, M., Rosenwald, A., Klapper, W., Eich, H.T., Baues, C., Zomas, A., Hallek, M., Dietlein, M., Kobe, C. and Diehl, V.
Lancet 404
(10450): 341-352.
27 July 2024
Open-ST: high-resolution spatial transcriptomics in 3D.
Schott, M., León-Periñán, D., Splendiani, E., Strenger, L., Licha, J.R., Pentimalli, T.M., Schallenberg, S., Alles, J., Samut Tagliaferro, S., Boltengagen, A., Ehrig, S., Abbiati, S., Dommerich, S., Pagani, M., Ferretti, E., Macino, G., Karaiskos, N. and Rajewsky, N.
Cell 187
(15): 3953-3972.e26.
25 July 2024
iSuRe-HadCre is an essential tool for effective conditional genetics.
Garcia-Gonzalez, I., Rocha, S.F., Hamidi, A., Garcia-Ortega, L., Regano, A., Sanchez-Muñoz, M.S., Lytvyn, M., Garcia-Cabero, A., Roig-Soucase, S., Schoofs, H., Castro, M., Sabata, H., Potente, M., Graupera, M., Makinen, T. and Benedito, R.
Nucleic Acids Research 52
(13): e56.
22 July 2024
Exploring mechanisms of lipid nanoparticle-mucus interactions in healthy and cystic fibrosis conditions.
Tafech, B., Rokhforouz, M.R., Leung, J., Sung, M.M., Lin, P.J., Sin, D.D., Lauster, D., Block, S., Quon, B.S., Tam, Y., Cullis, P., Feng, J.J. and Hedtrich, S.
Advanced Healthcare Materials 13
(18): e2304525.
17 July 2024
Intergenic risk variant rs56258221 skews the fate of naive CD4(+) T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.
Poch, T., Bahn, J., Casar, C., Krause, J., Evangelakos, I., Gilladi, H., Kunzmann, L.K., Laschtowitz, A., Iuso, N., Schäfer, A.M., Liebig, L.A., Steinmann, S., Sebode, M., Folseraas, T., Engesæter, L.K., Karlsen, T.H., Franke, A., Hubner, N., Schlein, C., Galun, E., Huber, S., Lohse, A.W., Gagliani, N., Schwinge, D. and Schramm, C.
Cell Reports Medicine 5
(7): 101620.
16 July 2024
Discovery of antimicrobial peptides in the global microbiome with machine learning.
Santos-Júnior, C.D., Torres, M.D.T., Duan, Y., Rodríguez Del Río, Á., Schmidt, T.S.B., Chong, H., Fullam, A., Kuhn, M., Zhu, C., Houseman, A., Somborski, J., Vines, A., Zhao, X.M., Bork, P., Huerta-Cepas, J., de la Fuente-Nunez, C. and Coelho, L.P.
Cell 187
(14): 3761-3778.e16.
11 July 2024
Piezo2 voltage-block regulates mechanical pain sensitivity.
Sánchez-Carranza, O., Chakrabarti, S., Kühnemund, J., Schwaller, F., Bégay, V., García-Contreras, J.A., Wang, Lin and Lewin, G.R.
Brain
10 July 2024
(In Press)
Liam tackles complex multimodal single-cell data integration challenges.
Rautenstrauch, P. and Ohler, U.
Nucleic Acids Research 52
(12): e52.
8 July 2024
REEV: review, evaluate and explain variants.
Hramyka, D., Sczakiel, H.L., Zhao, M.X., Stolpe, O., Nieminen, M., Adam, R., Danyel, M., Einicke, L., Hägerling, R., Knaus, A., Mundlos, S., Schwartzmann, S., Seelow, D., Ehmke, N., Mensah, M.A., Boschann, F., Beule, D. and Holtgrewe, M.
Nucleic Acids Research 52
(W1): W148-W158.
5 July 2024
Microproteins encoded by noncanonical ORFs are a major source of tumor-specific antigens in a liver cancer patient meta-cohort.
Camarena, M.E., Theunissen, P., Ruiz, M., Ruiz-Orera, J., Calvo-Serra, B., Castelo, R., Castro, C., Sarobe, P., Fortes, P., Perera-Bel, J. and Albà, M.M.
Science Advances 10
(28): eadn3628.
July 2024
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.
Wietek, J., Nozownik, A., Pulin, M., Saraf-Sinik, I., Matosevich, N., Gowrishankar, R., Gat, A., Malan, D., Brown, B.J., Dine, J., Imambocus, B.N., Levy, R., Sauter, K., Litvin, A., Regev, N., Subramaniam, S., Abrera, K., Summarli, D., Goren, E.M., Mizrachi, G., Bitton, E., Benjamin, A., Copits, B.A., Sasse, P., Rost, B.R., Schmitz, D., Bruchas, M.R., Soba, P., Oren-Suissa, M., Nir, Y., Wiegert, J.S. and Yizhar, O.
Nature Methods 21
(7): 1275-1287.
July 2024
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps.
Wu, J., Jones, N., Chao, P.H., Chan, V., Hohenwarter, L., Wu, A., Bergamo, M., Rodríguez-Rodríguez, C., Saatchi, K., Liang, A., Häfeli, U.O., Tan, Z., Hedtrich, S., Andrew, L.J. and Li, S.D.
Biomaterials 308
: 122567.
July 2024
Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E., Landthaler, M., Jung, K. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 35
(7): 838-853.
July 2024
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A., Plewka, J., Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A.N., Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova, Y., Minia, I., Mak, P., Landthaler, M., Nowotny, M., Dubin, G., Sattler, M., Suder, P., Popowicz, G.M., Pyrć, K. and Czarna, A.
Nucleic Acids Research 52
(11): 6441-6458.
24 June 2024
CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15
: 1383136.
24 June 2024
Genetic identification of medullary neurons underlying congenital hypoventilation.
Cui, K., Xia, Y., Patnaik, A., Salivara, A., Lowenstein, E.D., Isik, E.G., Knorz, A.L., Airaghi, L., Crotti, M., Garratt, A.N., Meng, F., Schmitz, D., Studer, M., Rijli, F.M., Nothwang, H.G., Rost, B.R., Strauß, U. and Hernandez-Miranda, L.R.
Science Advances 10
(25): eadj0720.
21 June 2024
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.
Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J.I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J.P., Zimmermann, H.G., Oertel, F.C., Ringelstein, M., Brandt, A.U., Paul, F., Aktas, O., Hartung, H.P., Wiendl, H., Meuth, S.G. and Albrecht, P.
Nature Communications 15
(1): 5243.
19 June 2024
Natural proteome diversity links aneuploidy tolerance to protein turnover.
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Nature 630
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6 June 2024
Transient stabilization of human cardiovascular progenitor cells from hPSCs in vitro reflects stage-specific heart development in vivo.
Bolesani, E., Bornhorst, D., Iyer, L.I., Zawada, D., Friese, N., Morgan, M., Lange, L., Gonzalez, D., Schrode, N., Leffler, A., Wunder, J., Franke, A., Drakhlis, L., Sebra, R., Schambach, A., Goedel, A., Dubois, N., Dobreva, G., Moretti, A., Zelarayán, L.C., Abdelilah-Seyfried, S. and Zweigerdt, R.
Cardiovascular Research
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5 June 2024
(In Press)
Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer.
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Leukemia 38
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June 2024
Extraembryonic gut endoderm cells undergo programmed cell death during development.
Batki, J., Hetzel, S., Schifferl, D., Bolondi, A., Walther, M., Wittler, L., Grosswendt, S., Herrmann, B.G. and Meissner, A.
Nature Cell Biology 26
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June 2024
Systematic benchmarking of single-cell ATAC-sequencing protocols.
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Nature Biotechnology 42
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June 2024
Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.
Grimes, K., Jeong, H., Amoah, A., Xu, N., Niemann, J., Raeder, B., Hasenfeld, P., Stober, C., Rausch, T., Benito, E., Jann, J.C., Nowak, D., Emini, R., Hoenicka, M., Liebold, A., Ho, A., Shuai, S., Geiger, H., Sanders, A.D. and Korbel, J.O.
Nature Genetics 56
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June 2024
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
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Nature Medicine 30
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June 2024
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression.
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Molecular Cancer 23
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29 May 2024
Basal delamination during mouse gastrulation primes pluripotent cells for differentiation.
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Developmental Cell 59
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20 May 2024
Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells.
Chiariello, A.M., Abraham, Alex, Bianco, S., Esposito, A., Fontana, A., Vercellone, F., Conte, M. and Nicodemi, M.
Nature Communications 15
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13 May 2024
Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.
Hurtado, A., Mota-Gómez, I., Lao, M., Real, F.M., Jedamzick, J., Burgos, M., Lupiáñez, D.G., Jiménez, R. and Barrionuevo, F.J.
Nature Communications 15
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7 May 2024
Next questions in autophagy.
Cuervo, A.M., Elazar, Z., Evans, C., Ge, L., Hansen, M., Jäättelä, M., Liang, J.R.A., Loos, B., Mizushima, N., Simon, A.K., Tooze, S., Yoshimori, T. and Nakamura, S.
Nature Cell Biology 26
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May 2024
Neighborhood-level inequalities and influencing factors of COVID-19 incidence in berlin based on Bayesian spatial modelling.
Zhuang, S., Wolf, K., Schmitz, T., Roth, A., Sun, Y., Savaskan, N. and Lakes, T.
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May 2024
Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish.
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Nature Communications 15
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29 April 2024
Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit.
Peng, Y., Bjelde, A., Aceituno, P.V., Mittermaier, F.X., Planert, H., Grosser, S., Onken, J., Faust, K., Kalbhenn, T., Simon, M., Radbruch, H., Fidzinski, P., Schmitz, D., Alle, H., Holtkamp, M., Vida, I., Grewe, B.F. and Geiger, J.R.P.
Science 384
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26 April 2024
Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D., Knapstein, P.R., Otto, E., Köhli, P., Sevecke, J., Graef, F., Graffmann, C., Fuchs, M., Jiang, S., Rickert, M., Erdmann, C., Appelt, J., Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G., Xie, W., Donat, A., Schinke, T., Ivanov, A., Tchouto, M.N., Beule, D., Frosch, K.H., Baranowsky, A., Tsitsilonis, S. and Keller, J.
Science Translational Medicine 16
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17 April 2024
Water conservation overrides osmotic diuresis during SGLT2 inhibition in patients with heart failure.
Marton, A., Saffari, S.E., Rauh, M., Sun, R.N., Nagel, A.M., Linz, P., Lim, T.T., Takase-Minegishi, K., Pajarillaga, A., Saw, S., Morisawa, N., Yam, W.K., Minegishi, S., Totman, J.J., Teo, S., Teo, L.L.Y., Ng, C.T., Kitada, K., Wild, J., Kovalik, J.P., Luft, F.C., Greasley, P.J., Chin, C.W.L., Sim, D.K.L. and Titze, J.
Journal of the American College of Cardiology 83
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16 April 2024
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
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Science Immunology 9
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12 April 2024
Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15
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11 April 2024
Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk.
de Biase, M.S., Massip, F., Wei, T.T., Giorgi, F.M., Stark, R., Stone, A., Gladwell, A., O'Reilly, M., Schütte, D., de Santiago, I., Meyer, K.B., Markowetz, F., Ponder, B.A.J., Rintoul, R.C. and Schwarz, R.F.
Genome Medicine 16
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8 April 2024
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C., Thery, F., Wirth, E.K., Ochs, S., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A.
Cardiovascular Research 120
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6 April 2024
Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143
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4 April 2024
Cell states in cancer: drivers, passengers, and trailers.
Gargiulo, G., Serresi, M. and Marine, J.C.
Cancer Discovery 14
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4 April 2024
Efficient recovery of complete gut viral genomes by combined short- and long-read sequencing.
Chen, J., Sun, C., Dong, Y., Jin, M., Lai, S., Jia, L., Zhao, X., Wang, H., Gao, N.L., Bork, P., Liu, Z., Chen, W.H. and Zhao, X.M.
Advanced Science 11
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3 April 2024
External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction.
Mehl, J., Farahani, S.K., Brauer, E., Klaus-Bergmann, A., Thiele, T., Ellinghaus, A., Bartels-Klein, E., Koch, K., Schmidt-Bleek, K., Petersen, A., Gerhardt, H., Vogel, V. and Duda, G.N.
Advanced Science 11
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3 April 2024
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
Zaupa, M., Nagaraj, N., Sylenko, A., Baier, H., Sawamiphak, S. and Filosa, A.
Neuron 112
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3 April 2024
A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on pulmonary circulation & right ventricular function.
Ameri, P., Mercurio, V., Pollesello, P., Anker, M.S., Backs, Jo., Bayes-Genis, A., Borlaug, B.A., Burkhoff, D., Caravita, S., Chan, S.Y., de Man, F., Giannakoulas, G., González, A., Guazzi, M., Hassoun, P.M., Hemnes, A.R., Maack, C., Madden, B., Melenovsky, V., Müller, O.J., Papp, Z., Pullamsetti, S.S., Rainer, P.P., Redfield, M.M., Rich, S., Schiattarella, G.G., Skaara, H., Stellos, K., Tedford, R.J., Thum, T., Vachiery, J.L., van der Meer, P., Van Linthout, S., Pruszczyk, P., Seferovic, P., Coats, A.J.S., Metra, M., Rosano, G., Rosenkranz, S. and Tocchetti, C.G.
European Journal of Heart Failure 26
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April 2024
Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.
Fislage, M., Winzeck, S., Woodrow, R., Lammers-Lietz, F., Stamatakis, E.A., Correia, M.M., Preller, J., Feinkohl, I., Hendrikse, J., Pischon, T., Spies, C.D., Slooter, A.J.C., Winterer, G., Menon, D.K. and Zacharias, N.
Alzheimer's and Dementia 20
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April 2024
Pangenome graph construction from genome alignments with Minigraph-Cactus.
Hickey, G., Monlong, J., Ebler, J., Novak, A.M., Eizenga, J.M., Gao, Y., Marschall, T., Li, H. and Paten, B.
Nature Biotechnology 42
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April 2024
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15
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30 March 2024
Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15
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23 March 2024
A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner, D., Sieverding, K., Srinidhi, J., Zellner, S., Secker, C., Yilmaz, R., Dyckow, J., Amr, S., Ponomarenko, A., Tunaboylu, E., Douahem, Y., Schlag, J.S., Rodríguez Martínez, L., Kislinger, G., Niemann, C., Nalbach, K., Ruf, W.P., Uhl, J., Hollenbeck, J., Schirmer, L., Catanese, A., Lobsiger, C.S., Danzer, K.M., Yilmazer-Hanke, D., Münch, C., Koch, P., Freischmidt, A., Fetting, M., Behrends, C., Parlato, R. and Weishaupt, J.H.
Journal of Experimental Medicine 221
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22 March 2024
Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10
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22 March 2024
Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022.
Baumgartner, F., Baer, C., Bamopoulos, S.A., Ayoub, E., Truger, M., Meggendorfer, M., Lenk, M., Hoermann, G., Hutter, S., Müller, H., Walter, W., Mueller, M.L., Nadarajah, Ni., Blombery, P., Keller, U., Kern, W., Haferlach, C. and Haferlach, T.
Blood 143
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21 March 2024
Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho, I.L., Li, C.Y., Wang, F., Zhao, L., Liu, J., Yen, E.Y., Dyke, C.A., Shah, R., Liu, Z., Çetin, A.O., Chu, Y., Citron, F., Attanasio, S., Corti, D., Darbaniyan, F., Del Poggetto, E., Loponte, S., Liu, J., Soeung, M., Chen, Z., Jiang, S., Jiang, H., Inoue, A., Gao, S., Deem, A., Feng, N., Ying, H., Kim, M., Giuliani, V., Genovese, G., Zhang, J., Futreal, A., Maitra, A., Heffernan, T., Wang, L., Do, K.A., Gargiulo, G., Draetta, G., Carugo, A., Lin, R. and Viale, A.
Science Advances 10
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15 March 2024
Rigorous science demands support of transgender scientists.
Aghi, K., Anderson, B.M., Castellano, B.M., Cunningham, A., Delano, M., Dickinson, E.S., von Diezmann, L., Forslund-Startceva, S.K., Grijseels, D.M., Groh, S.S., Guthman, E.M., Jayasinghe, I., Johnston, J., Long, S., McLaughlin, J.F., McLaughlin, M., Miyagi, M., Rajaraman, B., Sancheznieto, F., Scheim, A.I., Sun, S.E.D., Titmuss, F.D., Walsh, R.J. and Weinberg, Z.Y.
Cell 187
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14 March 2024
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83
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12 March 2024
Genetic determinants of micronucleus formation in vivo.
Adams, D.J., Barlas, B., McIntyre, R.E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J.R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N.A., Harle, V., Olvera-León, R., Robles-Espinoza, C.D., Speak, A.O., Geisler, N., Weninger, W.J., Geyer, S.H., Hewinson, J., Karp, N.A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M.S., Rowland, B.D., Lelliott, C.J., Del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A.G., Rooimans, M.A., de Lange, J., Mohun, T.J., Arends, M.J., Kentistou, K.A., Coelho, P.A., Zhao, Y., Zecchini, H., Perry, J.R.B., Jackson, S.P. and Balmus, G.
Nature 627
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7 March 2024
Canonical and non-canonical integrin-based adhesions dynamically interconvert.
Lukas, F., Matthaeus, C., López-Hernández, T., Lahmann, I., Schultz, N., Lehmann, M., Puchkov, D., Pielage, J., Haucke, V. and Maritzen, T.
Nature Communications 15
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7 March 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
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1 March 2024
Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383
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1 March 2024
Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced stage Hodgkin Lymphoma: results from the randomized international GHSG HD18 trial.
Ferdinandus, J., Müller, H., Damaschin, C., Jacob, A.S., Meissner, J., Krasniqi, F., Mey, U., Schöndube, D., Thiemer, J., Mathas, S., Zijlstra, J., Greil, R., Feuring-Buske, M., Markova, J., Rüffer, J.U., Kobe, C., Eich, H.T., Baues, C., Fuchs, M., Borchmann, P. and Behringer, K.
Annals of Oncology 35
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March 2024
Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories.
Gross, C.C., Schulte-Mecklenbeck, A., Steinberg, O.V., Wirth, T., Lauks, S., Bittner, S., Schindler, P., Baranzini, S.E., Groppa, S., Bellmann-Strobl, J., Bünger, N., Chien, C., Dawin, E., Eveslage, M., Fleischer, V., Gonzalez-Escamilla, G., Gisevius, B., Haas, J., Kerschensteiner, M., Kirstein, L., Korsukewitz, C., Lohmann, L., Lünemann, J.D., Luessi, F., Meyer Zu Hörste, G., Motte, J., Ruck, T., Ruprecht, K., Schwab, N., Steffen, F., Meuth, S.G., Paul, F., Wildemann, B., Kümpfel, T., Gold, R., Hahn, T., Zipp, F., Klotz, L. and Wiendl, H.
Science Translational Medicine 16
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March 2024
High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.
Müller, P., de la Cuesta-Zuluaga, J., Kuhn, M., Baghai Arassi, M., Treis, T., Blasche, S., Zimmermann, M., Bork, P., Patil, K.R., Typas, A., Garcia-Santamarina, S. and Maier, L.
Nature Protocols 19
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March 2024
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J., Meinhardt, J., Aschman, T., Chua, R.L., Farztdinov, V., Lukassen, S., Ten, F.W., Friebel, E., Ishaque, N., Franz, J., Huhle, V.H., Mothes, R., Peters, K., Thomas, C., Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D., Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S., Horst, D., Kurth, F., Müller, M.A., Gassen, N.C., Melchert, J., Jechow, K., Timmermann, B., Fernandez-Zapata, C., Böttcher, C., Stenzel, W., Krüger, E., Landthaler, M., Wyler, E., Corman, V., Stadelmann, C., Ralser, M., Eils, R., Heppner, F.L., Mülleder, M., Conrad, C. and Radbruch, H.
Nature Neuroscience 27
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March 2024
High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial.
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Nature Communications 15
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26 February 2024
MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.
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Nature Communications 15
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26 February 2024
The cycling and aging mouse female reproductive tract at single-cell resolution.
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Nature Communications 15
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9 February 2024
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8 February 2024
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
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Nature Communications 15
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6 February 2024
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
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Nature Communications 15
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5 February 2024
Gamma oscillation plasticity is mediated via parvalbumin interneurons.
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2 February 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
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2 February 2024
Genetic characterization of primary mediastinal B-cell lymphoma: pathogenesis and patient outcomes.
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1 February 2024
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Nature Immunology 25
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CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting.
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Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
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Nature Cancer 5
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Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
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Nature Communications 14
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Nature Communications 14
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19 December 2023
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
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18 December 2023
Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
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15 December 2023
Autoantibodies against the chemokine receptor 3 predict cardiovascular risk.
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Nature Communications 14
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11 December 2023
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.
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Nature Communications 14
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8 December 2023
Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.
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Science Advances 9
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December 2023
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
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Insm1 regulates mTEC development and immune tolerance.
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December 2023
The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
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Nature Communications 14
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30 November 2023
Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages.
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Developmental Cell 58
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20 November 2023
Latent human herpesvirus 6 is reactivated in CAR T cells.
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Nature 623
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16 November 2023
IL-33 expression is lower in current smokers at both transcriptomic and protein level.
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American Journal of Respiratory and Critical Care Medicine 208
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15 November 2023
Lipid nanoparticle-mediated hit-and-run approaches yield efficient and safe in situ gene editing in human skin.
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14 November 2023
XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
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Science Advances 9
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10 November 2023
Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
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Cell 186
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9 November 2023
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7 November 2023
Leveraging large language models for decision support in personalized oncology.
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JAMA Network Open 6
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Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
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November 2023
Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients.
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November 2023
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
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Nature Aging 3
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November 2023
Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine - a prospective cohort study by the AGMT.
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American Journal of Hematology 98
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November 2023
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
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Nature 622
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19 October 2023
Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
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Nature Communications 14
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17 October 2023
Molecular basis of ClC-6 function and its impairment in human disease.
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Science Advances 9
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13 October 2023
Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
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Genome Medicine 15
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12 October 2023
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
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Science 382
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12 October 2023
Mutational topography reflects clinical neuroblastoma heterogeneity.
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Cell Genomics 3
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11 October 2023
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
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Nature Communications 14
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4 October 2023
Play and tickling responses map to the lateral columns of the rat periaqueductal gray.
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4 October 2023
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
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Nature Chemical Biology 19
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October 2023
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
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Leukemia 37
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October 2023
Spatiotemporal, optogenetic control of gene expression in organoids.
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Nature Methods 20
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October 2023
Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.
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Genome Biology 24
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29 September 2023
Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
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Science Advances 9
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22 September 2023
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
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Nature Communications 14
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20 September 2023
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A.L., Tchenio, A., Benson, S., Vendrell, M., D'Alessandro, A., Beule, D., Pellerin, L., Mameli, M. and Paolicelli, R.C.
Nature Communications 14
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16 September 2023
Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases.
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Advanced Science 10
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5 September 2023
The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.
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Nature Communications 14
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1 September 2023
Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire.
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September 2023
Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.
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Genome Medicine 15
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23 August 2023
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
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Nature Communications 14
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22 August 2023
Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
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Nature Communications 14
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17 August 2023
Enterotypes of the human gut mycobiome.
Lai, S., Yan, Y., Pu, Y., Lin, S., Qiu, J.G., Jiang, B.H., Keller, M.I., Wang, M., Bork, P., Chen, W.H., Zheng, Y. and Zhao, X.M.
Microbiome 11
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11 August 2023
mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons.
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Molecular Cell 83
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3 August 2023
Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering.
Liu, C.C., Greenwald, N.F., Kong, A., McCaffrey, E.F., Leow, K.X., Mrdjen, D., Cannon, B.J., Rumberger, J.L., Varra, S.R. and Angelo, M.
Nature Communications 14
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1 August 2023
Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
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European Respiratory Journal 62
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1 August 2023
Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury.
Sanad, A.M., Qadri, F., Popova, E., Rodrigues, A.F., Heinbokel, T., Quach, S., Schulz, A., Bachmann, S., Kreutz, R., Alenina, N. and Bader, M.
Kidney International 104
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August 2023
Spatially resolved multiomics of human cardiac niches.
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Nature 619
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27 July 2023
SODAR: managing multiomics study data and metadata.
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GigaScience 12
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27 July 2023
Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.
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Journal of Hematology & Oncology 16
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22 July 2023
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
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Science 381
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21 July 2023
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
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Genome Medicine 15
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20 July 2023
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
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Neuron 111
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19 July 2023
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
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Nature Communications 14
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18 July 2023
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
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Nature Communications 14
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17 July 2023
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
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10 July 2023
Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C., Berger, H., Liu, L., Mollenkopf, H.J., Strowig, T. and Sigal, M.
Gut Microbes 15
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10 July 2023
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
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Blood 142
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6 July 2023
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
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Cell Stem Cell 30
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6 July 2023
e-RNA: a collection of web-servers for the prediction and visualisation of RNA secondary structure and their functional features.
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Nucleic Acids Research 51
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5 July 2023
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
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Nature Communications 14
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4 July 2023
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
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4 July 2023
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
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Journal of Clinical Investigation 133
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3 July 2023
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
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Nature Methods 20
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July 2023
Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
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Gastroenterology 165
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July 2023
Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09-09): a randomised, open-label, multicentre, phase 3 trial.
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Lancet Haematology 10
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Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
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Nature Genetics 55
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Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
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Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
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Nature Microbiology 8
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Inversion polymorphism in a complete human genome assembly.
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30 April 2023
Clinical and prognostic relevance of cardiac wasting in patients with advanced cancer.
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25 April 2023
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
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Nature 616
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20 April 2023
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Nature 616
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20 April 2023
The little skate genome and the evolutionary emergence of wing-like fins.
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20 April 2023
Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
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20 April 2023
Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
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12 April 2023
A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
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6 April 2023
Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
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5 April 2023
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
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The evolution of non-small cell lung cancer metastases in TRACERx.
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April 2023
Body composition and lung cancer-associated cachexia in TRACERx.
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Nature Medicine 29
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April 2023
A consensus protocol for functional connectivity analysis in the rat brain.
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April 2023
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
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Nature Medicine 29
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April 2023
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
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April 2023
COVID-19 and cellular senescence.
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April 2023
Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
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April 2023
Dynamic antagonism between key repressive pathways maintains the placental epigenome.
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Nature Cell Biology 25
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Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root.
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31 March 2023
Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
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31 March 2023
Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
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21 March 2023
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16 March 2023
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Molecular Cell 83
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16 March 2023
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
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Nature Communications 14
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3 March 2023
Mitochondrial DNA mutations as natural barcodes for lineage tracing of murine tumor models.
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1 March 2023
HNF1B alters an evolutionarily conserved nephrogenic program of target genes.
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March 2023
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
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Nature Immunology 24
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Massively parallel identification of mRNA localization elements in primary cortical neurons.
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Nature Neuroscience 26
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March 2023
The cellular coding of temperature in the mammalian cortex.
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23 February 2023
Nivolumab and doxorubicin, vinblastine, and dacarbazine in early-stage unfavorable Hodgkin Lymphoma: final analysis of the randomized german Hodgkin study group phase II NIVAHL trial.
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20 February 2023
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Nature Communications 14
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17 February 2023
Cryo-EM captures early ribosome assembly in action.
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Nature Communications 14
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17 February 2023
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.
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16 February 2023
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
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Nature Communications 14
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11 February 2023
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
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Science Advances 9
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10 February 2023
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19.
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Cell Genomics 3
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8 February 2023
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
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Cell Metabolism 35
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7 February 2023
First in vivo fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod.
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5 February 2023
SLC26A1 is a major determinant of sulfate homeostasis in humans.
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Journal of Clinical Investigation 133
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1 February 2023
Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
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February 2023
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
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February 2023
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy.
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February 2023
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
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CYCLeR - a novel tool for the full isoform assembly and quantification of circRNAs.
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25 January 2023
Radiofrequency induced heating of biodegradable orthopaedic screw implants during magnetic resonance imaging.
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The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
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proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes.
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The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.
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The gut microbiota in multiple sclerosis varies with disease activity.
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5 January 2023
Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.
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Nature Cancer 4
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January 2023
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
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Science Immunology 8
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January 2023
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia.
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January 2023
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
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Nature Chemical Biology 19
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January 2023
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations.
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Nature Biotechnology 44
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Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
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30 December 2022
Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by integrated multi-omic analyses.
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Microbiome 10
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28 December 2022
TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
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Journal for ImmunoTherapy of Cancer 10
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22 December 2022
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.
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Nature Communications 13
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21 December 2022
Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host.
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Microbiome 10
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16 December 2022
Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
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Nature Communications 13
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10 December 2022
Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
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Science Advances 8
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9 December 2022
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
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6 December 2022
Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments.
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Microbiome 10
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5 December 2022
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
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Nature Communications 13
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5 December 2022
Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
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1 December 2022
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
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European Respiratory Journal 60
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1 December 2022
RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
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Nature Methods 19
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December 2022
A critical period of translational control during brain development at codon resolution.
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Nature Structural & Molecular Biology 29
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December 2022
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
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Journal of the American Society of Nephrology 33
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December 2022
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
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Kidney International 102
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December 2022
Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease.
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December 2022
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
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Nature Biotechnology 40
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December 2022
Cell type diversity in a developing octopus brain.
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Nature Communications 13
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30 November 2022
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
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Nature Communications 13
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29 November 2022
DNA methylation-based classification of sinonasal tumors.
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Nature Communications 13
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28 November 2022
MicroRNAs are deeply linked to the emergence of the complex octopus brain.
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Science Advances 8
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25 November 2022
Non-redundant functions of group 2 innate lymphoid cells.
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Nature 611
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24 November 2022
Identification of environmental factors that promote intestinal inflammation.
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Nature 611
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24 November 2022
Semi-automated assembly of high-quality diploid human reference genomes.
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Nature 611
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17 November 2022
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L., Petkovic, M., Watkins, T.B.K., Colliver, E.C., Laskina, S., Thapa, N., Minussi, D.C., Navin, N., Swanton, C., Van Loo, P., Haase, K., Tarabichi, M. and Schwarz, R.F.
Genome Biology 23
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14 November 2022
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.
Boix, O., Martinez, M., Vidal, S., Giménez-Alejandre, M., Palenzuela, L., Lorenzo-Sanz, L., Quevedo, L., Moscoso, O., Ruiz-Orera, J., Ximénez-Embún, P., Ciriaco, N., Nuciforo, P., Stephan-Otto Attolini, C., Albà, M.M., Muñoz, J., Tian, T.V., Varela, I., Vivancos, A., Ramón Y Cajal, S., Muñoz, P., Rivas, C. and Abad, M.
Nature Communications 13
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11 November 2022
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13
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11 November 2022
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
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7 November 2022
TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41
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2 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
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Molecular Therapy 30
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2 November 2022
R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
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Journal of Clinical Investigation 132
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1 November 2022
Antibiotic resistance genes in river biofilms: a metagenomic approach toward the identification of sources and candidate hosts.
Kneis, D., Berendonk, T.U., Forslund, S.K. and Hess, S.
Environmental Science and Technology 56
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1 November 2022
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
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Cancer Immunology Research 10
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1 November 2022
The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
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Allergy 77
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November 2022
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L., Luebeck, J., Dehkordi, S.R., Colón, C.I., Li, R., Wong, I.T.L., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E., Moriceau, G., Zhang, X., Bailey, C., Houlahan, K.E., Yang, W., González, R.C., Swanton, C., Curtis, C., Jamal-Hanjani, M., Henssen, A.G., Law, J.A., Greenleaf, W.J., Lo, R.S., Mischel, P.S., Bafna, V. and Chang, H.Y.
Nature Genetics 54
(11): 1746–1754.
November 2022
Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B., Marenholz, I., Jeanrenaud, A.C.S.N., Meixner, L., Arnau-Soler, A., Rosillo-Salazar, O.D., Ghauri, A., Cibin, P., Blümchen, K., Schlags, R., Hansen, G., Seidenberg, J., Keil, T., Lau, S., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 150
(5): 1125-1134.
November 2022
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
Rückert, T., Lareau, C.A., Mashreghi, M.F., Ludwig, L.S. and Romagnani, C.
Nature Immunology 23
(11): 1551-1563.
November 2022
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27
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27 October 2022
H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10
(10): e005535.
27 October 2022
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13
(1): 6407.
27 October 2022
The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann, C., Spallek, R., Karpiuk, O., Heider, M., Schäffer, I., Zecha, J., Klaeger, S., Walzik, M., Öllinger, R., Engleitner, T., Wirth, M., Keller, U., Krönke, J., Rudelius, M., Kossatz, S., Rad, R., Kuster, B. and Bassermann, F.
EMBO Journal 41
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17 October 2022
Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C., Maghsudi, S. and Ohler, U.
Nucleic Acids Research 50
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14 October 2022
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Yanchus, C., Drucker, K.L., Kollmeyer, T.M., Tsai, R., Winick-Ng, W., Liang, M., Malik, A., Pawling, J., De Lorenzo, S.B., Ali, A., Decker, P.A., Kosel, M.L., Panda, A., Al-Zahrani, K.N., Jiang, L., Browning, J.W.L., Lowden, C., Geuenich, M., Hernandez, J.J., Gosio, J.T., Ahmed, M., Loganathan, S.K., Berman, J., Trcka, D., Michealraj, K.A., Fortin, J., Carson, B., Hollingsworth, E.W., Jacinto, S., Mazrooei, P., Zhou, L., Elia, A., Lupien, M., He, H.H., Murphy, D.J., Wang, L., Abyzov, A., Dennis, J.W., Maass, P.G., Campbell, K., Wilson, M.D., Lachance, D.H., Wrensch, M., Wiencke, J., Mak, T., Pennacchio, L.A., Dickel, D.E., Visel, A., Wrana, J., Taylor, M.D., Zadeh, G., Dirks, P., Eckel-Passow, J.E., Attisano, L., Pombo, A., Ida, C.M., Kvon, E.Z., Jenkins, R.B. and Schramek, D.
Science 378
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7 October 2022
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana, S., Kretschmer, S., Hunger, S., Yan, X., Kuster, D., Traikov, S., Zillinger, T., Gentzel, M., Elangovan, S., Dasgupta, P., Chappidi, N., Lucas, N., Maser, K.I., Maatz, H., Rapp, A., Marchand, V., Chang, Y.T., Motorin, Y., Hubner, N., Hartmann, G., Hyman, A.A., Alberti, S. and Lee-Kirsch, M.A.
Molecular Cell 82
(19): 3712-3728.e10.
6 October 2022
Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto, M., Kaminski, M.M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A.J., Tan, X., Kim, H., Dighe, A.S., Collins, J.J. and Stevens, M.M.
Nature Nanotechnology 17
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October 2022
The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T., Rose, J.C., Chen, C.Y., Pichugin, Y., Xie, L., Tang, J., Hung, K.L., Yost, K.E., Shi, Q., Erb, M.L., Rajkumar, U., Wu, S., Taschner-Mandl, S., Bernkopf, M., Swanton, C., Liu, Z., Huang, W., Chang, H.Y., Bafna, V., Henssen, A.G., Werner, B. and Mischel, P.S.
Nature Genetics 54
(10): 1527-1533.
October 2022
Best practice standards for circular RNA research.
Nielsen, A.F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T.B., Irimia, M., Kadener, S., Kristensen, L.S., Legnini, I., Morlando, M., Jarlstad Olesen, M.T., Pasterkamp, R.J., Preibisch, S., Rajewsky, N., Suenkel, C. and Kjems, J.
Nature Methods 19
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October 2022
Framework and baseline examination of the German National Cohort (NAKO).
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European Journal of Epidemiology 37
(10): 1107-1124.
October 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
(10): msac175.
October 2022
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel, A.R., Szabo, Q., Chiariello, A.M., Chudzik, K., Schöpflin, R., Rothe, P., Mattei, A.L., Zehnder, To., Harnett, D., Laupert, V., Bianco, S., Hetzel, S., Glaser, J., Phan, M.H.Q., Schindler, M., Ibrahim, D.M., Paliou, C., Esposito, A., Prada-Medina, C.A., Haas, S.A., Giere, P., Vingron, M., Wittler, L., Meissner, A., Nicodemi, M., Cavalli, G., Bantignies, F., Mundlos, S. and Robson, M.I.
Cell 185
(20): 3689-3704.
29 September 2022
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I., Seeger, T., Bruyneel, A.A.N., Termglinchan, V., Monte, E., Lim, E.W., Vadgama, N., Furihata, T., Gavidia, A.A., Arthur Ataam, J., Bharucha, N., Martinez-Amador, N., Ameen, M., Nair, P., Serrano, R., Kaur, B., Feyen, D.A.M., Diecke, S., Snyder, M.P., Metallo, C.M., Mercola, M. and Karakikes, I.
European Heart Journal 43
(36): 3477-3489.
21 September 2022
The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G., Vanzo, R., Amitash, S., Martín-Doncel, E., Coscia, F., Mund, A., Lerdrup, M., Benada, J., Boos, D. and Toledo, L.
Molecular Cell 82
(18): 3350-3365.
15 September 2022
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
Poetz, F., Lebedeva, S., Schott, J., Lindner, D., Ohler, U. and Stoecklin, G.
Genome Biology 23
(1): 193.
12 September 2022
Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R., Rautenstrauch, P., Ghanbari, M., James, A.R., Kirchler, M., Ohler, U., Konigorski, S. and Lippert, C.
Nature Communications 13
(1): 5332.
10 September 2022
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M., Foglierini, M., Khorkova, S., Vázquez García, C., Ratswohl, C., Davydov, A.N., Turchaninova, M.A., Daubenberger, C., Chudakov, D.M., Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119
(36): e2205470119.
6 September 2022
Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. and Daumke, O.
Science Advances 8
(35): eabo4946.
2 September 2022
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D., Borsa, M., Puleston, D.J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S.S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G. and Simon, A.K.
Nature Communications 13
(1): 5174.
2 September 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J., Berangi, M., Yiannakou, C., Silva, E., Francischello, R., Kuehne, A., Niendorf, T., Könneker, S., Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15
: 382-391.
September 2022
Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N., Jahn, E., Saadati, M., Bullinger, L., Larson, R.A., Ottone, T., Amadori, S., Prior, T.W., Brandwein, J.M., Appelbaum, F.R., Medeiros, B.C., Tallman, M.S., Ehninger, G., Heuser, M., Ganser, A., Pallaud, C., Gathmann, I., Krzykalla, J., Benner, A., Bloomfield, C.D., Thiede, C., Stone, R.M., Döhner, H. and Döhner, K.
Leukemia 36
(9): 2218-2227.
September 2022
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93
(9): 960-971.
September 2022
Drivers and determinants of strain dynamics following fecal microbiota transplantation.
Schmidt, T.S.B., Li, S.S., Maistrenko, O.M., Akanni, W., Coelho, L.P., Dolai, S., Fullam, A., Glazek, A.M., Hercog, R., Herrema, H., Jung, F., Kandels, S., Orakov, A., Thielemann, R., von Stetten, M., Van Rossum, T., Benes, V., Borody, T.J., de Vos, W.M., Ponsioen, C.Y., Nieuwdorp, M. and Bork, P.
Nature Medicine 28
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September 2022
Mutations in TAF8 cause a neurodegenerative disorder.
Wong, K.M., Jepsen, W.M., Efthymiou, S., Salpietro, V., Sanchez-Castillo, M., Yip, J., Kriouile, Y., Diegmann, S., Dreha-Kulaczewski, S., Altmüller, J., Thiele, H., Nürnberg, P., Toosi, M.B., Akhondian, J., Ghayoor Karimiani, E., Hummel-Abmeier, H., Huppke, B., Houlden, H., Gärtner, J., Maroofian, R. and Huppke, P.
Brain 145
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September 2022
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso, I., Zujo, L., Wiest, I., Kodajova, P., Timelthaler, G., Edtmayer, S., Zrimšek, M., Kollmann, S., Giordano, C., Kothmayer, M., Neubauer, H.A., Dey, S., Schlederer, M., Schmalzbauer, B.S., Limberger, T., Probst, C., Pusch, O., Högler, S., Tangermann, S., Merkel, O., Schiefer, A.I., Kornauth, C., Prutsch, N., Zimmerman, M., Abraham, B., Anagnostopoulos, J., Quintanilla-Martinez, L., Mathas, S., Wolf, P., Stoiber, D., Staber, P.B., Egger, G., Klapper, W., Woessmann, W., Look, T.A., Gunning, P., Turner, S.D., Moriggl, R., Lagger, S. and Kenner, L.
Molecular Cancer 21
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31 August 2022
ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.
Tsybulskyi, V. and Meyer, I.M.
Nucleic Acids Research 50
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26 August 2022
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019.
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Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D. and Junker, J.P.
Nature Genetics 54
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August 2022
Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
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Haematologica 107
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August 2022
A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
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Science Advances 8
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August 2022
Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 33
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August 2022
Deep Visual Proteomics defines single-cell identity and heterogeneity.
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Nature Biotechnology 40
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August 2022
Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
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August 2022
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
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Annals of the Rheumatic Diseases 81
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August 2022
B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
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Haematologica 107
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August 2022
The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
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August 2022
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
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Nature Communications 13
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25 July 2022
Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
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Nature Communications 13
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13 July 2022
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
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12 July 2022
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
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Nature Communications 13
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8 July 2022
Biosynthetic potential of the global ocean microbiome.
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Nature 607
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7 July 2022
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A.S., Mollenkopf, H.J., Berger, H., Tacke, F. and Sigal, M.
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4 July 2022
In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
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Nature Genetics
July 2022
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
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Nature Genetics 54
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July 2022
Identification of early neurodegenerative pathways in progressive multiple sclerosis.
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Nature Neuroscience 25
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July 2022
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
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Molecular Cancer 21
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10 June 2022
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
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Science Advances 8
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8 June 2022
A faecal microbiota signature with high specificity for pancreatic cancer.
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Gut 71
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7 June 2022
Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
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Nature Communications 13
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7 June 2022
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
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Journal of Experimental Medicine 219
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6 June 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K. and Chu, V.T.
Science Advances 8
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3 June 2022
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82
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2 June 2022
Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L.. and Löhning, M.
Nature Communications 13
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1 June 2022
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
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EClinicalMedicine 48
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June 2022
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
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Nature Metabolism 4
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June 2022
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.
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Nature Cancer 3
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June 2022
Proton-gated anion transport governs macropinosome shrinkage.
Zeziulia, M., Blin, S., Schmitt, F.W., Lehmann, M. and Jentsch, T.J.
Nature Cell Biology 24
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June 2022
Identifying tumor cells at the single-cell level using machine learning.
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Genome Biology 23
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30 May 2022
Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma.
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29 May 2022
Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
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Science Advances 8
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27 May 2022
Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
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26 May 2022
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial.
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26 May 2022
Serotonin limits generation of chromaffin cells during adrenal organ development.
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Nature Communications 13
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25 May 2022
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
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Nature Communications 13
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18 May 2022
Brain-wide interactions during hippocampal sharp wave ripples.
Nitzan, N., Swanson, R., Schmitz, D. and Buzsáki, G.
Proceedings of the National Academy of Sciences of the United States of America 119
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17 May 2022
The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.
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Journal for ImmunoTherapy of Cancer 10
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17 May 2022
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
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16 May 2022
The genomic and transcriptional landscape of primary central nervous system lymphoma.
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Nature Communications 13
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10 May 2022
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
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5 May 2022
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
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Molecular Therapy 30
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4 May 2022
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
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2 May 2022
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation.
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Nature Cell Biology 24
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May 2022
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
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Nature Cancer 3
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28 April 2022
Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1.
Ludwig, L.S., Lareau, C.A., Bao, E.L., Liu, N., Utsugisawa, T., Tseng, A.M., Myers, S.A., Verboon, J.M., Ulirsch, J.C., Luo, W., Muus, C., Fiorini, C., Olive, M.E., Vockley, C.M., Munschauer, M., Hunter, A., Ogura, H., Yamamoto, T., Inada, H., Nakagawa, S., Ozono, S., Subramanian, V., Chiarle, R., Glader, B., Carr, S.A., Aryee, M.J., Kundaje, A., Orkin, S., Regev, A., McCavit, T., Kanno, H. and Sankaran, V.G.
Blood 139
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21 April 2022
Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S., Smyshlyaev, G., Letunic, I., Maistrenko, O.M., Coelho, L.P., Orakov, A., Forslund, S.K., Hildebrand, F., Luetge, M., Schmidt, T.S.B., Barabas, O. and Bork, P.
Nucleic Acids Research 50
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8 April 2022
Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T., Himmerkus, N., Meoli, L., Fromm, A., Sewerin, S., Kriuchkova, N., Nagel, O., Ladilov, Y., Krug, S., Quintanova, C., Stumpp, M., Garbe-Schönberg, D., Westernströer, U., Merkel, C., Brinkhus, M., Altmüller, J., Schweiger, M., Mueller, D., Mutig, K., Morawski, M., Halbritter, J., Milatz, S., Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33
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April 2022
Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F. and Damm, F.
Leukemia 36
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April 2022
Statistical analysis in the German National Cohort (NAKO) - specific aspects and general recommendations.
Kuss, O., Becher, H., Wienke, A., Ittermann, T., Ostrzinski, S., Schipf, S., Schmidt, C.O., Leitzmann, M., Pischon, T., Krist, L., Roll, S., Sand, M., Pohlabeln, H., Rach, S., Jöckel, K.H., Stang, A., Mueller, U.A., Werdecker, A., Westerman, R., Greiser, K.H. and Michels, K.B.
European Journal of Epidemiology 37
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April 2022
Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D., Oshima, M., Stange, D.E. and Sigal, M.
Gastroenterology 162
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April 2022
A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome.
Widjaja, A.A., Shekeran, S., Adami, E., Goh, J., Tan, J., Viswanathan, S., Lim, S.Y., Tan, P.H., Hübner, N., Coffman, T. and Cook, S.
Journal of the American Society of Nephrology 33
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April 2022
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M.J. and Bock, A.
Cell 185
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31 March 2022
BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13
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24 March 2022
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74
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15 March 2022
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G., Conlon, T.M., Jeridi, A., Kim, R., Ertüz, Z., Lang, N.J., Ansari, M., Novikova, M., Jiang, D., Strunz, M., Gaianova, M., Hollauer, C., Gabriel, C., Angelidis, I., Doll, S., Pestoni, J.C., Edelmann, S.L., Kohlhepp, M.S., Guillot, A., Bassler, K., Van Eeckhoutte, H.P., Kayalar, Ö., Konyalilar, N., Kanashova, T., Rodius, S., Ballester-López, C., Genes Robles, C.M., Smirnova, N., Rehberg, M., Agarwal, C., Krikki, I., Piavaux, B., Verleden, S.E., Vanaudenaerde, B., Königshoff, M., Dittmar, G., Bracke, K.R., Schultze, J.L., Watz, H., Eickelberg, O., Stoeger, T., Burgstaller, G., Tacke, F., Heissmeyer, V., Rinkevich, Y., Bayram, H., Schiller, H.B., Conrad, M., Schneider, R. and Yildirim, A.Ö.
Nature Communications 13
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14 March 2022
Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial.
Arends, C.M., Dimitriou, S., Stahler, A., Hablesreiter, R., Strzelecka, P.M., Stein, C.M., Tilgner, M., Saiki, R., Ogawa, S., Bullinger, L., Modest, D.P., Stintzing, S., Heinemann, V. and Damm, F.
Blood 139
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10 March 2022
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O., Halpert, G., Schimke, L.F., Ostrinski, Y., Vojdani, A., Baiocchi, G.C., Freire, P.P., Filgueiras, I.S., Zyskind, I., Lattin, M.T., Tran, F., Schreiber, S., Marques, A.H.C., Plaça, D.R., Fonseca, D.L.M., Humrich, J.Y., Müller, A., Giil, L.M., Graßhoff, H., Schumann, A., Hackel, A., Junker, J., Meyer, C., Ochs, H.D., Lavi, Y.B., Scheibenbogen, C., Dechend, R., Jurisica, I., Schulze-Forster, K., Silverberg, J.I., Amital, H., Zimmerman, J., Heidecke, H., Rosenberg, A.Z., Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13
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9 March 2022
Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly.
Li, H., Janssens, J., De Waegeneer, M., Kolluru, S.S., Davie, K., Gardeux, V., Saelens, W., David, F.P.A., Brbić, M., Spanier, K., Leskovec, J., McLaughlin, C.N., Xie, Q., Jones, R.C., Brueckner, K., Shim, J., Tattikota, S.G., Schnorrer, F., Rust, K., Nystul, T.G., Carvalho-Santos, Zi., Ribeiro, C., Pal, S., Mahadevaraju, S., Przytycka, T.M., Allen, A.M., Goodwin, S.F., Berry, C.W., Fuller, M.T., White-Cooper, H., Matunis, E.L., DiNardo, S., Galenza, A., O'Brien, L.E., Dow, J.A.T., Jasper, H., Oliver, B., Perrimon, N., Deplancke, B., Quake, S.R., Luo, L. and Aerts, S.
Science 375
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4 March 2022
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M., von Arx, A.S., Cruz-Ochoa, N., Dawson, K., Ivanov, A., Mueller, F.S., Lin, H.Y., Amport, R., Mildenberger, W., Mattei, D., Beule, D., Földy, C., Greter, M., Notter, T. and Meyer, U.
Science Advances 8
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4 March 2022
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M., Yu, H., Yu, X., Liang, S., Hu, Y., Luo, Y., Izsvák, Z., Sun, C. and Wang, J.
Cell Stem Cell 29
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3 March 2022
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J., Bamopoulos, S.A., Köse, H., Orben, F., Zang, C., Pons, M., den Dekker, A.T., Brouwer, R.W.W., Baluapuri, A., Habringer, S., Reichert, M., Illendula, A., Krämer, O.H., Schick, M., Wolf, E., van IJcken, W.F.J., Esposito, I., Keller, U., Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119
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1 March 2022
Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Fiskin, E., Lareau, C.A., Ludwig, L.S., Eraslan, G., Liu, F., Ring, A.M., Xavier, R.J. and Regev, A.
Nature Biotechnology 40
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March 2022
Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T., Zhang, Y., Vadas, O., Roske, Y., Gulluni, F., De Santis, M.C., Zagar, A.V., Stephanowitz, H., Hirsch, E., Liu, F., Daumke, O., Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29
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March 2022
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić, S., Prada-Medina, C.A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C.M., Antony, P., Timmermann, B., Sauer, S., Pereira, S.L., Schwamborn, J.C., May, P., Grünewald, A. and Spielmann, M.
Brain 145
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March 2022
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S., Busch, C.J.L., Molawi, K., Geirsdottir, L., Maurizio, J., Vargas Aguilar, S., Belahbib, H., Gimenez, G., Yuda, R.A.A., Burkon, M., Favret, J., Gholamhosseinian Najjar, S., de Laval, B., Kandalla, P.K., Sarrazin, S., Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23
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March 2022
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.
Shahan, R., Hsu, C.W., Nolan, T.M., Cole, B.J., Taylor, I.W., Greenstreet, L., Zhang, S., Afanassiev, A., Vlot, A.H.C., Schiebinger, G., Benfey, P.N. and Ohler, U.
Developmental Cell 57
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28 February 2022
Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.
Miller, T.E., Lareau, C.A., Verga, J.A., DePasquale, E.A.K., Liu, V., Ssozi, D., Sandor, K., Yin, Y., Ludwig, L.S., El Farran, C.A., Morgan, D.M., Satpathy, A.T., Griffin, G.K., Lane, A.A., Love, J.C., Bernstein, B.E., Sankaran, V.G. and van Galen, P.
Nature Biotechnology 40
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24 February 2022
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13
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23 February 2022
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L.E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J.C., Scherer, C., Rubio-Acero, R., Eser, T., Deák, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K., Tomas, L., Schulz, C., Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M., Iannacone, M., Zimmer, R., Mertins, P., Hubner, N., Hoelscher, M., Massberg, S., Stark, K. and Nicolai, L.
Nature Communications 13
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23 February 2022
Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Mohammed, M., Johnson, D.N., Wang, L.A., Harden, S.W., Sheng, W., Spector, E.A., Elsaafien, K., Bader, M., Steckelings, U.M., Scott, K.A., Frazier, C.J., Sumners, C., Krause, E.G. and de Kloet, A.D.
Cardiovascular Research 118
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21 February 2022
Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O., Zincke, F., Eckert, A., Kobelt, D., Preissner, S., Liebeskind, J.M., Gunkel, N., Putzker, K., Lewis, J., Preissner, S., Kortüm, B., Walther, W., Mura, K., Bourne, P.E., Stein, U. and Preissner, R.
Clinical and Translational Medicine 12
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20 February 2022
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Reincke, S.M., Yuan, M., Kornau, H.C., Corman, V.M., van Hoof, S., Sánchez-Sendin, E., Ramberger, M., Yu, W., Hua, Y., Tien, H., Schmidt, M.L., Schwarz, T., Jeworowski, L.M., Brandl, S.E., Rasmussen, H.F., Homeyer, M.A., Stöffler, L., Barner, M., Kunkel, D., Huo, S., Horler, J., von Wardenburg, N., Kroidl, I., Eser, T.M., Wieser, A., Geldmacher, C., Hoelscher, M., Gänzer, H., Weiss, G., Schmitz, D., Drosten, C., Prüss, H., Wilson, I.A. and Kreye, J.
Science 375
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18 February 2022
Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
Bishop, M.R., Dickinson, M., Purtill, D., Barba, P., Santoro, A., Hamad, N., Kato, K., Sureda, A., Greil, R., Thieblemont, C., Morschhauser, F., Janz, M., Flinn, I., Rabitsch, W., Kwong, Y.L., Kersten, M.J, Minnema, M.C., Holte, H., Chan, E.H.L., Martinez-Lopez, J., Müller, A.M.S., Maziarz, R.T., McGuirk, J.P., Bachy, E., Le Gouill, S., Dreyling, M., Harigae, H., Bond, D., Andreadis, C., McSweeney, P., Kharfan-Dabaja, M., Newsome, S., Degtyarev, E., Awasthi, R., Del Corral, C., Andreola, G., Masood, A., Schuster, S.J., Jäger, U., Borchmann, P. and Westin, J.R.
New England Journal of Medicine 386
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17 February 2022
Microbiome and metabolome features of the cardiometabolic disease spectrum.
Fromentin, S., Forslund, S.K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M.T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R., Coelho, L.P., Falony, G., Fellahi, S., Galan, P., Galleron, N., Helft, G., Hoyles, L., Isnard, R., Le Chatelier, E., Julienne, H., Olsson, L., Pedersen, H.K., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Schmidt, T.S.B., Vieira-Silva, S., Li, P., Zimmermann-Kogadeeva, M., Lewinter, C., Søndertoft, N.B., Hansen, T.H., Gauguier, D., Gøtze, J.P., Køber, L., Kornowski, R., Vestergaard, H., Hansen, T., Zucker, J.D., Hercberg, S., Letunic, I., Bäckhed, F., Oppert, J.M., Nielsen, J., Raes, J., Bork, P., Stumvoll, M., Segal, E., Clément, K., Dumas, M.E., Ehrlich, S.D. and Pedersen, O.
Nature Medicine 28
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17 February 2022
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Schnoeder, T.M., Schwarzer, A., Jayavelu, A.K., Hsu, C.J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S.A., Nafria, M., Jiang, L., Dai, Y.T., Chen, Z., Chen, S.J., Kellaway, S.G., Ptasinska, A., Ng, E.S., Stanley, E.G., Elefanty, A.G., Buschbeck, M., Bierhoff, H., Brodt, S., Matziolis, G., Fischer, K.D., Hochhaus, A., Chen, C.W., Heidenreich, O., Mann, M., Lane, S.W., Bullinger, L., Ori, A., von Eyss, B., Bonifer, C. and Heidel, F.
Blood 139
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17 February 2022
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia, A., Zimmermann, F., Schumann, P., Jasina, A., Roessler, J., Schmidt, D., Heinze, P., Kaisler, J., Nageswaran, V., Aigner, A., Ceglarek, U., Cineus, R., Hegazy, A.N., van der Vorst, E.P.C., Döring, Y., Strauch, C.M., Nemet, I., Tremaroli, V., Dwibedi, C., Kränkel, N., Leistner, D.M., Heimesaat, M.M., Bereswill, S., Rauch, G., Seeland, U., Soehnlein, O., Müller, D.N., Gold, R., Bäckhed, F., Hazen, S.L., Haghikia, A. and Landmesser, U.
European Heart Journal 43
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7 February 2022
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D., Wyler, E., Landthaler, M., Obermayer, B., von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185
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3 February 2022
Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
Kaneshige, A., Kaji, T., Zhang, L., Saito, H., Nakamura, A., Kurosawa, T., Ikemoto-Uezumi, M., Tsujikawa, K., Seno, S., Hori, M., Saito, Y., Matozaki, T., Maehara, K., Ohkawa, Y., Potente, M., Watanabe, S., Braun, T., Uezumi, A. and Fukada, S.I.
Cell Stem Cell 29
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3 February 2022
Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
Offer, S., Hartner, E., Di Bucchianico, S., Bisig, C., Bauer, S., Pantzke, J., Zimmermann, E.J., Cao, X., Binder, S., Kuhn, E., Huber, A., Jeong, S., Käfer, U., Martens, P., Mesceriakovas, A., Bendl, J., Brejcha, R., Buchholz, A., Gat, D., Hohaus, T., Rastak, N., Jakobi, G., Kalberer, M., Kanashova, T., Hu, Y., Ogris, C., Marsico, A., Theis, F., Pardo, M., Gröger, T., Oeder, S., Orasche, J., Paul, A., Ziehm, T., Zhang, Z.H., Adam, T., Sippula, O., Sklorz, M., Schnelle-Kreis, J., Czech, H., Kiendler-Scharr, A., Rudich, Y. and Zimmermann, R.
Environmental Health Perspectives 130
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3 February 2022
Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C., Polovitskaya, M.M., Delgado, B.D., Jentsch, T.J. and Long, S.B.
Science Advances 8
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2 February 2022
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brieño-Enríquez, M.A., Bronner, G.N., Coen, C., Delaney, M.A., Dengler-Crish, C.M., Edrey, Y.H., Faulkes, C.G., Frankel, D., Friedlander, G., Gibney, P.A., Gorbunova, V., Hine, C., Holmes, M.M., Jarvis, J.U.M., Kawamura, Y., Kutsukake, N., Kenyon, C., Khaled, W.T., Kikusui, T., Kissil, J., Lagestee, S., Larson, J., Lauer, A., Lavrenchenko, L.A., Lee, A., Levitt, J.B., Lewin, G.R., Lewis Hardell, K.N., Lin, T.D., Mason, M.J., McCloskey, D., McMahon, M., Miura, K., Mogi, K., Narayan, V., O'Connor, T.P., Okanoya, K., O'Riain, M.J., Park, T.J., Place, N.J., Podshivalova, K., Pamenter, M.E., Pyott, S.J., Reznick, J., Ruby, J.G., Salmon, A.B., Santos-Sacchi, J., Sarko, D.K., Seluanov, A., Shepard, A., Smith, M., Storey, K.B., Tian, X., Vice, E.N., Viltard, M., Watarai, Ak., Wywial, E., Yamakawa, M., Zemlemerova, E.D., Zions, M. and Smith, E.S.J.
Biological Reviews 97
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February 2022
Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W., Akalin, A. and Ohler, U.
Nature Machine Intelligence 4
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February 2022
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
Talmor-Barkan, Y., Bar, N., Shaul, A.A., Shahaf, N., Godneva, A., Bussi, Y., Lotan-Pompan, M., Weinberger, A., Shechter, A., Chezar-Azerrad, C., Arow, Z., Hammer, Y., Chechi, K., Forslund, S.K., Fromentin, S., Dumas, M.E., Ehrlich, S.D., Pedersen, O., Kornowski, R. and Segal, E.
Nature Medicine 28
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February 2022
The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E., Brückner, L. and Henssen, A.G.
Nature Genetics 54
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February 2022
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke, A.C., Doebele, C., Zindel, A., Lee, K.S., Rieke, S.A., Ceribelli, M., Comoglio, F., Phelan, J.D., Wang, J.Q., Pikman, Y., Jahn, D., Häupl, B., Schneider, C., Scheich, S., Tosto, F.A., Bohnenberger, H., Stauder, P., Schnütgen, F., Slabicki, M., Coulibaly, Z.A., Wolf, S., Bojarczuk, K., Chapuy, B., Brandts, C.H., Stroebel, P., Lewis, C.A., Engelke, M., Xu, X., Kim, H., Dang, T.H., Schmitz, R., Hodson, D.J., Stegmaier, K., Urlaub, H., Serve, H., Schmitt, C.A., Kreuz, F., Knittel, G., Rabinowitz, J.D., Reinhardt, H.C., Vander Heiden, M.G., Thomas, C., Staudt, L.M., Zenz, T. and Oellerich, T.
Blood 139
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27 January 2022
Towards the biogeography of prokaryotic genes.
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Nature 601
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13 January 2022
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
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Nature Communications 13
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12 January 2022
AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
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7 January 2022
An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
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Science Advances 8
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7 January 2022
Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
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Circulation Research 130
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7 January 2022
A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.
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Journal of Experimental Medicine 219
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3 January 2022
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
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January 2022
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
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Cell 184
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22 December 2021
Extracellular matrix in heart Failure: role of ADAMTS5 in proteoglycan remodeling.
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Circulation 144
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21 December 2021
Deep tissue scattering compensation with three-photon F-SHARP.
Berlage, C., Tantirigama, M.L.S., Babot, M., Di Battista, D., Whitmire, C., Papadopoulos, I.N., Poulet, J.F.A., Larkum, M. and Judkewitz, B.
Optica 8
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20 December 2021
Combinatorial, additive and dose-dependent drug-microbiome associations.
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Nature 600
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16 December 2021
CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N., Eckstein, J., Wallach, I., Nordmeyer, S., Kelm, M., Kirchner, M., Goubergrits, L., Schafstedde, M., Hennemuth, A., Kraus, M., Grune, T., Mertins, P., Kuehne, T. and Holzhütter, H.G.
Circulation 144
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14 December 2021
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F., Corbo, J., Levdansky, Y., Spiegelhalter, A., Lindner, D., Magg, V., Lebedeva, S., Schweiggert, J., Schott, J., Valkov, E. and Stoecklin, G.
Nature Communications 12
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9 December 2021
The SEQC2 epigenomics quality control (EpiQC) study.
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Genome Biology 22
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6 December 2021
Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.
Glaser, L.V., Steiger, M., Fuchs, A., van Bömmel, A., Einfeldt, E., Chung, H.R., Vingron, M. and Meijsing, S.H.
Nucleic Acids Research 49
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2 December 2021
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
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December 2021
Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Hur, J., Otegbeye, E., Joh, H.K., Nimptsch, K., Ng, K., Ogino, S., Meyerhardt, J.A., Chan, A.T., Willett, W.C., Wu, K., Giovannucci, E. and Cao, Y.
Gut 70
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December 2021
Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
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Haematologica 106
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December 2021
Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L., Gohil, S.H., Lareau, C., Ludwig, L.S., Parry, E.M., Huang, T., Li, S., Zhang, W., Livitz, D., Leshchiner, I., Parida, L., Getz, G., Rassenti, L.Z., Kipps, T.J., Brown, J.R., Davids, M.S., Neuberg, D.S., Livak, K.J., Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11
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December 2021
Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H., Badillo-Lisakowski, V., Britto-Borges, T., Kubli, D.A., Jüttner, R., Parakkat, P., Lopez Carballo, J., Hüttemeister, J., Liss, M., Hansen, A., Dieterich, C., Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13
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December 2021
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Rosswog, C., Bartenhagen, C., Welte, A., Kahlert, Y., Hemstedt, N., Lorenz, W., Cartolano, M., Ackermann, S., Perner, S., Vogel, W., Altmüller, J., Nürnberg, P., Hertwig, F., Göhring, G., Lilienweiss, E., Stütz, A.M., Korbel, J.O., Thomas, R.K., Peifer, M. and Fischer, M.
Nature Genetics 53
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December 2021
Compendium of 530 metagenome-assembled bacterial and archaeal genomes from the polar Arctic Ocean.
Royo-Llonch, M., Sánchez, P., Ruiz-González, C., Salazar, G., Pedrós-Alió, C., Sebastián, M., Labadie, K., Paoli, L., M. Ibarbalz, F., Zinger, L., Churcheward, B., Chaffron, S., Eveillard, D., Karsenti, E., Sunagawa, S., Wincker, P., Karp-Boss, L., Bowler, C. and Acinas, S.G.
Nature Microbiology 6
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December 2021
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Golic, M. and Kräker, K.
Diabetologia 64
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December 2021
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., Boch, T., Jann, J.C., Nowak, D., Hofmann, W.K., Müller-Tidow, C., Hübschmann, D., Alexandrov, T., Benes, V., Trumpp, A., Paulsen, M., Velten, L. and Haas, S.
Nature Immunology 22
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December 2021
Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W., Kukalev, A., Harabula, I., Zea-Redondo, L., Szabó, D., Meijer, M., Serebreni, L., Zhang, Y., Bianco, S., Chiariello, A.M., Irastorza-Azcarate, I., Thieme, C.J., Sparks, T.M., Carvalho, S., Fiorillo, L., Musella, F., Irani, E., Triglia, E.T., Kolodziejczyk, A.A., Abentung, A., Apostolova, G., Paul, E.J., Franke, V., Kempfer, R., Akalin, A., Teichmann, S.A., Dechant, G., Ungless, M.A., Nicodemi, M., Welch, L., Castelo-Branco, G. and Pombo, A.
Nature 599
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25 November 2021
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J., Huska, M., Cwikla, M.C., Kruetzfeldt, L.M., Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y., Burkert, M., Guergen, D., Szymansky, A., Astrahantseff, K., Kuenkele, A., Haase, K., Fischer, M., Deubzer, H.E., Hertwig, F., Hundsdoerfer, P., Henssen, A.G., Schwarz, R.F., Schulte, J.H. and Eggert, A.
Nature Communications 12
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23 November 2021
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
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Nature Communications 12
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16 November 2021
Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F., Postmus, D., Brown, R.J.P., Wyler, E., Neumann, E., Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10
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16 November 2021
Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C., Dietert, K., Schotsaert, M., Martínez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M., Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S., Gruber, A.D., Hoetzenecker, W., Steinkellner, H., Purfuerst, B., Motz, R., Di Pierro, F., Lamprecht, B., Osterrieder, N., Landthaler, M., Drosten, C., García-Sastre, A., Langer, R., Ralser, M., Eils, R., Reimann, M., Fan, D.N.Y. and Schmitt, C.A.
Nature 599
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11 November 2021
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
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Immunity 54
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9 November 2021
Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K., Teranishi, K., Ambroso, M.R., Isas, J.M., Vazquez-Sarandeses, E., Lee, J.Y., Melo, A.A., Pandey, P., Merken, D., Berndt, L., Lammers, M., Daumke, O., Chang, K., Haworth, I.S. and Langen, R.
Nature Communications 12
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9 November 2021
Unravelling the collateral damage of antibiotics on gut bacteria.
Maier, L., Goemans, C.V., Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., Garcia-Santamarina, S., Cacace, E., Zhang, B., Gekeler, C., Banerjee, T., Anderson, E.E., Milanese, A., Löber, U., Forslund, S.K., Patil, K.R., Zimmermann, M., Stecher, B., Zeller, G., Bork, P. and Typas, A.
Nature 599
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4 November 2021
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A., Gärtner, A., Cyganek, L., Tiburcy, M., Tuleta, I., Wellers, L., Folsche, L., Hobbach, A.J., von Frieling-Salewsky, M., Unger, A., Hucke, A., Koser, F., Kassner, A., Sielemann, K., Streckfuß-Bömeke, K., Hasenfuss, G., Goedel, A., Laugwitz, K.L., Moretti, A., Gummert, J.F., Dos Remedios, C.G., Reinecke, H., Knöll, R., van Heesch, S., Hubner, N., Zimmermann, W.H., Milting, H. and Linke, W.A.
Science Translational Medicine 13
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3 November 2021
A medullary centre for lapping in mice.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
Nature Communications 12
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2 November 2021
Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures.
Kreye, J., Wright, S.K., van Casteren, A., Stoeffler, L., Machule, M.L., Reincke, S.M., Nikolaus, M., van Hoof, S., Sanchez-Sendin, E., Homeyer, M.A., Gómez, C.C., Kornau, H.C., Schmitz, D., Kaindl, A.M., Boehm-Sturm, P., Mueller, S., Wilson, M.A., Upadhya, M.A., Dhangar, D.R., Greenhill, S., Woodhall, G., Turko, P., Vida, I., Garner, C.C., Wickel, J., Geis, C., Fukata, Y., Fukata, M. and Prüss, H.
Journal of Experimental Medicine 218
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1 November 2021
Reporting guidelines for human microbiome research: the STORMS checklist.
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Nature Medicine 27
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November 2021
Cannabidiol converts NF(κ)B into a tumor suppressor in glioblastoma with defined antioxidative properties.
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Neuro-Oncology 23
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November 2021
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Nature Communications 12
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19 October 2021
Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
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Journal of Experimental & Clinical Cancer Research 40
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15 October 2021
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
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Journal of Cachexia Sarcopenia and Muscle 12
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14 October 2021
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
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7 October 2021
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EMBO Molecular Medicine 13
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7 October 2021
Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
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October 2021
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October 2021
Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
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October 2021
CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.
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October 2021
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
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Nature Biotechnology 39
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October 2021
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.
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Nature Cell Biology 23
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October 2021
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
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October 2021
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27 September 2021
Using DNA sequencing data to quantify T cell fraction and therapy response.
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Nature 597
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23 September 2021
Bioaccumulation of therapeutic drugs by human gut bacteria.
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Nature 597
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23 September 2021
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
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Nature Communications 12
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22 September 2021
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
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Nature Communications 12
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17 September 2021
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
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Nature Communications 12
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13 September 2021
CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
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Nature Communications 12
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13 September 2021
Locus specific epigenetic modalities of random allelic expression imbalance.
Marion-Poll, L., Forêt, B., Zielinski, D., Massip, F., Attia, M., Carter, A.C., Syx, L., Chang, H.Y., Gendrel, A.V. and Heard, E.
Nature Communications 12
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9 September 2021
Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
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EMBO Molecular Medicine 13
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7 September 2021
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
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Nature 597
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2 September 2021
NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport.
Moriel, N., Senel, E., Friedman, N., Rajewsky, N., Karaiskos, N. and Nitzan, M.
Nature Protocols 16
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September 2021
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
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Nature Communications 12
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20 August 2021
A simple pressure-assisted method for MicroED specimen preparation.
Zhao, J., Xu, H., Lebrette, H., Carroni, M., Taberman, H., Högbom, M. and Zou, X.
Nature Communications 12
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19 August 2021
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
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Nature Communications 12
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11 August 2021
M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
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Journal of Controlled Release 330
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10 August 2021
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
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Nature Communications 12
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10 August 2021
Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
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American Journal of Human Genetics 108
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5 August 2021
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Young, K., Eudy, E., Bell, R., Loberg, M.A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.D. and Trowbridge, J.J.
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5 August 2021
Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
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Nature Ecology & Evolution 5
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August 2021
High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
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Journal for ImmunoTherapy of Cancer 9
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30 July 2021
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
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Proceedings of the National Academy of Sciences of the United States of America 118
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27 July 2021
Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
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Proceedings of the National Academy of Sciences of the United States of America 118
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13 July 2021
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
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Circulation 144
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13 July 2021
Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Huhn, K., Linz, P., Pemsel, F., Michalke, B., Seyferth, S., Kopp, C., Chaudri, M.A., Rothhammer, V., Dörfler, A., Uder, M., Nagel, A.M., Müller, D.N., Waschbisch, A., Lee, D.H., Bäuerle, T., Linker, R.A. and Haase, S.
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13 July 2021
Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.
Liu, J., Tassinari, M., Souza, D.P., Naskar, S., Noel, J.K., Bohuszewicz, O., Buck, M., Williams, T.A., Baum, B. and Low, H.H.
Cell 184
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8 July 2021
CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
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Nature Genetics 53
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July 2021
Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp.
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July 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
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Genome Biology 22
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28 June 2021
Post-myocardial infarction heart failure dysregulates the bone vascular niche.
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Nature Communications 12
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25 June 2021
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
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Nature Communications 12
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21 June 2021
Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F., Gossmann, T.I., Frioux, C., Özkurt, E., Myers, P.N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H.B. and Bork, P.
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14 June 2021
GUNC: detection of chimerism and contamination in prokaryotic genomes.
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13 June 2021
Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
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Nature Communications 12
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11 June 2021
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
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10 June 2021
Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S., Schultze, H., Shastry, K.L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N.A., Ktena, S., Tran, F., Bitzer, M., Ossowski, S., Casadei, N., Herr, C., Petersheim, D., Behrends, U., Kern, F., Fehlmann, T., Schommers, P., Lehmann, C., Augustin, M., Rybniker, J., Altmüller, J., Mishra, N., Bernardes, J.P., Krämer, B., Bonaguro, L., Schulte-Schrepping, J., De Domenico, E., Siever, C., Kraut, M., Desai, M., Monnet, B., Saridaki, M., Siegel, C.M., Drews, A., Nuesch-Germano, M., Theis, H., Heyckendorf, J., Schreiber, S., Kim-Hellmuth, S., Nattermann, J., Skowasch, D., Kurth, I., Keller, A., Bals, R., Nürnberg, P., Rieß, O., Rosenstiel, P., Netea, M.G., Theis, F., Mukherjee, S., Backes, M., Aschenbrenner, A.C., Ulas, T., Breteler, M.M.B., Giamarellos-Bourboulis, E.J., Kox, M., Becker, M., Cheran, S., Woodacre, M.S., Goh, E.L. and Schultze, J.L.
Nature 594
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10 June 2021
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118
(23): e2101119118.
8 June 2021
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
Cuello, F., Knaust, A.E., Saleem, U., Loos, M., Raabe, J., Mosqueira, D., Laufer, S., Schweizer, M., Kraak, P., Flenner, F., Ulmer, B.M, Braren, I., Yin, X., Theofilatos, K., Ruiz-Orera, J., Patone, G., Klampe, B., Schulze, T., Piasecki, A., Pinto, Y., Vink, A., Hübner, N., Harding, S., Mayr, M., Denning, C., Eschenhagen, T. and Hansen, A.
EMBO Molecular Medicine 13
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7 June 2021
Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M. and Junker, J.P.
Nature Communications 12
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7 June 2021
Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
Schmalbrock, L.K., Dolnik, A., Cocciardi, S., Sträng, E., Theis, F., Jahn, N., Panina, E., Blätte, T.J., Herzig, J.K., Skambraks, S., Rücker, F.G., Gaidzik, V.I., Paschka, P., Fiedler, W., Salih, H.R., Wulf, G.G., Schroeder, T., Lübbert, M., Schlenk, R.F., Thol, F., Heuser, M., Larson, R.A., Ganser, A., Stunnenberg, H.G., Minucci, S., Stone, R.M., Bloomfield, C.D., Döhner, H., Döhner, K. and Bullinger, L.
Blood 137
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3 June 2021
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J.A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M.C., Chatelain, C., Carninci, P., de Hoon, M.J.L., Wasserman, W.W., Bréhélin, L. and Lecellier, C.H.
Nature Communications 12
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2 June 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort.
Birukov, A., Andersen, L.B., Andersen, M.S., Nielsen, J.H., Nielsen, F.g, Kyhl, H.B., Jørgensen, J.S., Grandjean, P., Dechend, R. and Jensen, T.K.
Environment International 151
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June 2021
Sodium and its manifold impact on our immune system.
Jobin, K., Müller, D.N., Jantsch, J. and Kurts, C.
Trends in Immunology 42
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June 2021
PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial.
Kreissl, S., Goergen, H., Buehnen, I., Kobe, C., Moccia, A., Greil, R., Eichenauer, D.A., Zijlstra, J.M., Markova, J., Meissner, J., Feuring-Buske, M., Soekler, M., Beck, H.J., Willenbacher, W., Ludwig, W.D., Pabst, T., Topp, M.S., Hitz, F., Bentz, M., Keller, U.B., Kühnhardt, D., Ostermann, H., Hertenstein, B., Aulitzky, W., Maschmeyer, G., Vieler, T., Eich, H., Baues, C., Stein, H., Fuchs, M., Diehl, V., Dietlein, M., Engert, A. and Borchmann, P.
Lancet Haematology 8
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June 2021
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A., Roske, Y., Yamada, S., Uehata, T., Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49
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21 May 2021
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M., Schrezenmeier, J.F., Richter-Pechanska, P., Dolnik, A., Hick, T.P., Schleich, K., Cai, X., Fan, D.N.Y., Lohneis, P., Masswig, S., Denker, S., Busse, A., Knittel, G., Flümann, R., Childs, D., Childs, L., Gätjens-Sanchez, A.M., Bullinger, L., Rosenwald, A., Reinhardt, H.C. and Schmitt, C.A.
Blood 137
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20 May 2021
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin.
Mahn, M., Saraf-Sinik, I., Patil, P., Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S. and Yizhar, O.
Neuron 109
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19 May 2021
Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M., Subramaniam, S., Chomsky-Hecht, O., Tsemakhovich, V., Flockerzi, V., Klussmann, E., Hirsch, J.A., Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118
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17 May 2021
Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49
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7 May 2021
DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L., Venkataramanan, S., Rogowski, K.J., Wyler, E., Wilkins, K., Tejura, M., Thai, B., Krol, J., Filipowicz, W., Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49
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May 2021
Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin.
Fiorillo, L., Musella, F., Conte, M., Kempfer, R., Chiariello, A.M., Bianco, S., Kukalev, A., Irastorza-Azcarate, I., Esposito, A., Abraham, A., Prisco, A., Pombo, A. and Nicodemi, M.
Nature Methods 18
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May 2021
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K., Fogo, M.S., Pinto, B.G.G., Alves, A.Y., Suzuki, A.M., Morales, A.G., Ezquina, S., Sosa, O.J., Sutton, G.J., Sunaga-Franze, D.Y., Bueno, A.P., Seabra, G., Sardinha, L., Costa, S.S., Rosenberg, C., Zachi, E.C., Sertie, A.L., Martins-de-Souza, D., Reis, E.M., Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26
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May 2021
Assessing dysferlinopathy patients over three years with a new motor scale.
Jacobs, M., James, M.K., Lowes, L.P., Alfano, L.N., Eagle, M., Lofra, R.M., Moore, U., Feng, J., Rufibach, L.E., Rose, K., Duong, T., Bello, L., Pedrosa-Hernández, I., Holsten, S., Sakamoto, C., Canal, A., Práxedes, N.S.A., Thiele, S., Siener, C., Vandevelde, B., DeWolf, B., Maron, E., Guglieri, M., Hogrel, J.Y., Blamire, A.M., Carlier, P.G., Spuler, S., Day, J.W., Jones, K.J., Bharucha-Goebel, D.X., Salort-Campana, E., Pestronk, A., Walter, M.C., Paradas, C., Stojkovic, T., Mori-Yoshimura, M., Bravver, E., Díaz-Manera, J., Pegoraro, E., Mendell, J.R., Mayhew, A.G. and Straub, V.
Annals of Neurology 89
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May 2021
Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E., Schewe, J., Zhang, J., Dinh, H.A., Forslund, S.K., Markó, L., Hellmig, N., Peters, J., Muller, D.N., Lifton, R.P., Nottoli, T., Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118
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27 April 2021
Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J., Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M., Schmuck, R., Mollenkopf, H.J., Brinkmann, V., Tacke, F., Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13
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9 April 2021
Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J., Shi, C., Costa, A.S.H., Choi, J., Kim, J., Doddaballapur, A., Sugino, T., Ong, Y.T., Castro, M., Zimmermann, B., Kaulich, M., Guenther, S., Wilhelm, K., Kubota, Y., Braun, T., Koh, G.Y., Grosso, A.R., Frezza, C. and Potente, M.
Nature Cell Biology 23
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April 2021
SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C., Günther, U., Eddison, M., Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18
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April 2021
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K., Hablesreiter, R., Inoue, Y., Yoshida, K., Briest, F., Christen, F., Kakiuchi, N., Yoshizato, T., Shiozawa, Y., Shiraishi, Y., Striefler, J.K., Bischoff, S., Lohneis, P., Putter, H., Blau, O., Keilholz, U., Bullinger, L., Pelzer, U., Hummel, M., Riess, H., Ogawa, S., Sinn, M. and Damm, F.
EBioMedicine 66
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April 2021
Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens, B., Schulze, A., Wysocki, J., Lin, M.H., Ye, M., Kanwar, Y.S., Bader, M., Velez, J.C.Q., Miner, J.H. and Batlle, D.
Kidney International 99
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April 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W.
Cancer Research 81
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April 2021
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12
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30 March 2021
Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.
Wirbel, J., Zych, K., Essex, M., Karcher, N., Kartal, E., Salazar, G., Bork, P., Sunagawa, S. and Zeller, G.
Genome Biology 22
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30 March 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
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26 March 2021
Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J.R., Sutanto, H., Pacheu Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuβ, G., Gotthardt, M., Rog-Zielinska, E.A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J.W., Heijman, J., Voigt, N., Cyganek, L., Lenz, C. and Lehnart, S.E.
Circulation Research 128
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19 March 2021
Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge.
Sieberts, S.K., Schaff, J., Duda, M., Pataki, B.Á., Sun, M., Snyder, P., Daneault, J.F., Parisi, F., Costante, G., Rubin, U., Banda, P., Chae, Y., Chaibub Neto, E., Dorsey, E.R., Aydın, Z., Chen, A., Elo, L.L., Espino, C., Glaab, E., Goan, E., Golabchi, F.N., Görmez, Y., Jaakkola, M.K., Jonnagaddala, J., Klén, R., Li, D., McDaniel, C., Perrin, D., Perumal, T.M., Rad, N.M., Rainaldi, E., Sapienza, S., Schwab, P., Shokhirev, N., Venäläinen, M.S., Vergara-Diaz, G., Zhang, Y., Wang, Y., Guan, Y., Brunner, D., Bonato, P., Mangravite, L.M. and Omberg, L.
NPJ Digital Medicine 4
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19 March 2021
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M., Eichner, R., Stroh, J., Morath, V., Kuisl, A., Zecha, J., Lawatscheck, J., Baek, K., Garz, A.K., Rudelius, M., Deuschle, F.C., Keller, U., Lemeer, S., Verbeek, M., Götze, K.S., Skerra, A., Weber, W.A., Buchner, J., Schulman, B.A., Kuster, B., Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81
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18 March 2021
Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R., Hilal, T., Schmidt, S., Qin, B., Schwefel, D., Vieira-Vieira, C.H., Mielke, T., Bürger, J., Loerke, J., Amikura, K., Flügel, T., Ueda, T., Selbach, M., Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81
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18 March 2021
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G., Altamirano, F., Kim, S.Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K.M., Villalobos, E., Spurgin, S.B., Waldman, M., Jiang, N., May, H.I., Hill, T.M., Luo, Y., Yoo, H., Zaha, V.G., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 12
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16 March 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
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15 March 2021
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40
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15 March 2021
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C., Luecken, M.D., Eraslan, G., Sikkema, L., Waghray, A., Heimberg, G., Kobayashi, Y., Vaishnav, E.D., Subramanian, A., Smillie, C., Jagadeesh, K.A., Duong, E.T., Fiskin, E., Triglia, E.T., Ansari, M., Cai, P., Lin, B., Buchanan, J., Chen, S., Shu, J., Haber, A.L., Chung, H., Montoro, D.T., Adams, T., Aliee, H., Allon, S.J., Andrusivova, Z., Angelidis, I., Ashenberg, O., Bassler, K., Bécavin, C., Benhar, I., Bergenstråhle, J., Bergenstråhle, L., Bolt, L., Braun, E., Bui, L.T., Callori, S., Chaffin, M., Chichelnitskiy, E., Chiou, J., Conlon, T.M., Cuoco, M.S., Cuomo, A.S.E., Deprez, M., Duclos, G., Fine, D., Fischer, D.S., Ghazanfar, S., Gillich, A., Giotti, B., Gould, J., Guo, M., Gutierrez, A.J., Habermann, A.C., Harvey, T., He, P., Hou, X., Hu, L., Hu, Y., Jaiswal, A., Ji, L., Jiang, P., Kapellos, T.S., Kuo, C.S., Larsson, L., Leney-Greene, M.A., Lim, K., Litviňuková, M., Ludwig, L.S., Lukassen, S., Luo, W., Maatz, H., Madissoon, E., Mamanova, L., Manakongtreecheep, K., Leroy, S., Mayr, C.H., Mbano, I.M., McAdams, A.M., Nabhan, A.N., Nyquist, S.K., Penland, L., Poirion, O.B., Poli, S., Qi, C.C., Queen, R., Reichart, D., Rosas, I., Schupp, J.C., Shea, C.V., Shi, X., Sinha, R., Sit, R.V., Slowikowski, K., Slyper, M., Smith, N.P., Sountoulidis, A., Strunz, M., Sullivan, T.B., Sun, D., Talavera-López, C., Tan, P., Tantivit, J., Travaglini, K.J., Tucker, N.R., Vernon, K.A., Wadsworth, M.H., Waldman, J., Wang, X., Xu, K., Yan, W., Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27
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2 March 2021
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
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1 March 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L., Story, B.A., Hernández-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Frömel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Müller-Tidow, C., Trumpp, A., Haas, S. and Steinmetz, L.M.
Nature Communications 12
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1 March 2021
Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J.P., Petzold, G.C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N.J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D.E., Bonvento, G., Butt, A.M., Chen, W.T., Cohen-Salmon, M., Cunningham, C., Deneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J.E., Goldman, S.A., Götz, M., Gutiérrez, A., Haydon, P.G., Heiland, D.H., Hol, E.M., Holt, M.G., Iino, M., Kastanenka, K.V., Kettenmann, H., Khakh, B.S., Koizumi, S., Lee, C.J., Liddelow, S.A., MacVicar, B.A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A.V., Murai, K.K., Norris, C.M., Okada, S., Oliet, S.H.R., Oliveira, J.F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B.G., Pfrieger, F.W., Poskanzer, K.E., Quintana, F.J., Ransohoff, R.M., Riquelme-Perez, M., Robel, S., Rose, C.R., Rothstein, J.D., Rouach, N., Rowitch, D.H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R.A., Vitorica, J., Wanner, I.B., Wood, L.B., Wu, J., Zheng, B., Zimmer, E.R., Zorec, R., Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24
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March 2021
Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A., Serfling, R., Möller, J., Thomas, R., De Faveri, C., Zabel, U., Scarselli, M., Beck-Sickinger, A.G., Bock, A., Coin, I., Lohse, M.J. and Annibale, P.
Nature Protocols 16
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March 2021
Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I., Poon, E., Henssen, A.G., Dorado Garcia, H., Gatti, M., Giansanti, C., Jamin, Y., Ade, C.P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G. and Eilers, M.
Nature Cancer 2
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March 2021
Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J., Company, C., Dramaretska, Y., Barozzi, I., Göhrig, A., Kertalli, S., Großmann, M., Naumann, H., Sánchez-Bailón, M.P., Hulsman, D., Glass, R., Squatrito, M., Serresi, M. and Gargiulo, G.
Cancer Discovery 11
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March 2021
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang, H., Hooper, C., Kelly, M., Steeples, V., Simon, J.N., Beglov, J., Azad, A.J., Leinhos, L., Bennett, P., Ehler, E., Kalisch-Smith, J.I., Sparrow, D.B., Fischer, R., Heilig, R., Isackson, H., Ehsan, M., Patone, G., Huebner, N., Davies, B., Watkins, H. and Gehmlich, K.
Basic Research in Cardiology 116
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26 February 2021
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24 February 2021
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15 February 2021
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February 2021
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February 2021
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February 2021
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27 January 2021
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27 January 2021
On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
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21 January 2021
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21 January 2021
Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum.
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20 January 2021
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13 January 2021
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12 January 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
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11 January 2021
OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.
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8 January 2021
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8 January 2021
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1 January 2021
Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
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Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection.
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USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
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Nature Neuroscience 24
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January 2021
Early response to first-line anti-PD-1 treatment in Hodgkin lymphoma: a PET-based analysis from the prospective, randomized phase II NIVAHL trial.
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Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
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January 2021
Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
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24 December 2020
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
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Nature Communications 11
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21 December 2020
Cells of the adult human heart.
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Nature 588
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17 December 2020
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
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17 December 2020
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
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15 December 2020
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
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Nature Communications 11
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11 December 2020
Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
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11 December 2020
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7 December 2020
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
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Nature 588
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3 December 2020
A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration.
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3 December 2020
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Science Advances 6
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2 December 2020
CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
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2 December 2020
CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
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1 December 2020
S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants.
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25 November 2020
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
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19 November 2020
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P.O., Rouault, C., André, S., Marquet, F., Andreelli, F., Salem, J.E., Assmann, K., Bastard, J.P., Forslund, S., Le Chatelier, E., Falony, G., Pons, N., Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T.H., Pedersen, H.K., Lewinter, C., Sønderskov, N.B., Køber, L., Vestergaard, H., Hansen, T., Zucker, J.D., Galan, P., Dumas, M.E., Raes, J., Oppert, J.M., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S.D., Stumvoll, M., Pedersen, O., Aron-Wisnewsky, J., Clément, K. and Bäckhed, F.
Nature Communications 11
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18 November 2020
Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations.
Pandey, S., Gruenbaum, A., Kanashova, T., Mertins, P., Cluzel, P. and Chevrier, N.
Cell Systems 11
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18 November 2020
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir, A., Möller, J., Arimont, M., Bobkov, V., Perpiñá-Viciano, C., Hoffmann, C., Inoue, A., Heukers, R., de Graaf, C., Smit, M.J., Annibale, P. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 117
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17 November 2020
Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C., Ritterhoff, T., Weber, A., Janowska, M.K., Mustroph, M., Sommer, T. and Klevit, R.E.
EMBO Journal 39
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16 November 2020
Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M., Valasarajan, C., Werner, A., Boeckel, J.N., Bischoff, F.C., John, D., Weirick, T., Glaser, S.F., Rossbach, O., Jaé, N., Demolli, S., Khassafi, F., Yuan, K., de Jesus Perez, V.A., Michalik, K.M., Chen, W., Seeger, W., Guenther, A., Wasnick, R.M., Uchida, S., Zeiher, A.M., Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202
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15 November 2020
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Kreye, J., Reincke, S.M., Kornau, H.C., Sánchez-Sendin, E., Corman, V.M., Liu, H., Yuan, M., Wu, N.C., Zhu, X., Lee, C.C.D., Trimpert, J., Höltje, M., Dietert, K., Stöffler, L., von Wardenburg, N., van Hoof, S., Homeyer, M.A., Hoffmann, J., Abdelgawad, A., Gruber, A.D., Bertzbach, L.D., Vladimirova, D., Li, L.Y., Barthel, P.C., Skriner, K., Hocke, A.C., Hippenstiel, S., Witzenrath, M., Suttorp, N., Kurth, F., Franke, C., Endres, M., Schmitz, D., Jeworowski, L.M., Richter, A., Schmidt, M.L., Schwarz, T., Müller, M.A., Drosten, C., Wendisch, D., Sander, L.E., Osterrieder, N., Wilson, I.A. and Prüss, H.
Cell 183
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12 November 2020
Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K., Lim, E.L., Petkovic, M., Elizalde, S., Birkbak, N.J., Wilson, G.A., Moore, D.A., Grönroos, E., Rowan, A., Dewhurst, S.M., Demeulemeester, J., Dentro, S.C., Horswell, S., Au, L., Haase, K., Escudero, M., Rosenthal, R., Bakir, M.A., Xu, H., Litchfield, K., Lu, W.T., Mourikis, T.P., Dietzen, M., Spain, L., Cresswell, G.D., Biswas, D., Lamy, P., Nordentoft, I., Harbst, K., Castro-Giner, F., Yates, L.R., Caramia, F., Jaulin, F., Vicier, C., Tomlinson, I.P.M., Brastianos, P.K., Cho, R.J., Bastian, B.C., Dyrskjøt, L., Jönsson, G.B., Savas, P., Loi, S., Campbell, P.J., Andre, F., Luscombe, N.M., Steeghs, N., Tjan-Heijnen, V.C.G., Szallasi, Z., Turajlic, S., Jamal-Hanjani, M., Van Loo, P., Bakhoum, S.F., Schwarz, R.F., McGranahan, N. and Swanton, C.
Nature 587
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5 November 2020
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S., Hopf, L.V.M., Bock-Bierbaum, T., Lally, C.C.M., Spahn, C.M.T. and Daumke, O.
Nature Communications 11
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2 November 2020
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel, B., Czimmerer, Z., Halasz, L., Boto, P., Kolostyak, Z., Poliska, S., Berger, W.K., Tzerpos, P., Nagy, G., Horvath, A., Hajas, G., Cseh, T., Nagy, A., Sauer, S., Francois-Deleuze, J., Szatmari, I., Bacsi, A. and Nagy, L.
Genes & Development 34
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1 November 2020
The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D., Formichetti, S., Junker, J.P., Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16
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1 November 2020
Monogenic variants in dystonia: an exome-wide sequencing study.
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Lancet Neurology 19
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November 2020
Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y., Gilboa, T., van Kooten, X.F., Kobelt, D., Huttner, D., Stein, U. and Meller, A.
ACS Nano 14
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27 October 2020
A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C., Mueller, L., Ruzittu, S., Mah, N., Willnow, D., Darrigrand, J.F., Wilson, H., Khosravinia, D., Mahmoud, A.A., Risolino, M., Selleri, L. and Spagnoli, F.M.
Developmental Cell 55
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26 October 2020
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D. and le Noble, F.
Nature Communications 11
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21 October 2020
Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.
Leistner, D.M., Kränkel, N., Meteva, D., Abdelwahed, Y.S., Seppelt, C., Stähli, B.E., Rai, H., Skurk, C., Lauten, A., Mochmann, H.C., Fröhlich, G., Rauch-Kröhnert, U., Flores, E., Riedel, M., Sieronski, L., Kia, S., Strässler, E., Haghikia, A., Dirks, F., Steiner, J. K., Mueller, D.N., Volk, H.D., Klotsche, J., Joner, M., Libby, P. and Landmesser, U.
European Heart Journal 41
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20 October 2020
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
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20 October 2020
Microscopy with undetected photons in the mid-infrared.
Kviatkovsky, I., Chrzanowski, H.M., Avery, E.G., Bartolomaeus, H. and Ramelow, S.
Science Advances 6
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14 October 2020
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan, H., Glažar, P., Latini, C., Heizler, K., Haase, J., Hett, R., Anders, M., Weichmann, F., Bruckmann, A., Van den Berg, D., Hüttelmaier, S., Rajewsky, N., Hackl, C. and Meister, G.
Nucleic Acids Research 48
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9 October 2020
The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M., Haas, S.A., Franchini, P., Xiong, P., Simakov, O., Kuhl, H., Schöpflin, R., Heller, D., Moeinzadeh, M.H., Heinrich, V., Krannich, T., Bressin, A., Hartmann, M.F., Wudy, S.A., Dechmann, D.K.N., Hurtado, A., Barrionuevo, F.J., Schindler, M., Harabula, I., Osterwalder, M., Hiller, M., Wittler, L., Visel, A., Timmermann, B., Meyer, A., Vingron, M., Jiménez, R., Mundlos, S. and Lupiáñez, D.G.
Science 370
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9 October 2020
R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V., Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48
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9 October 2020
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
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5 October 2020
GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G., Custodio, J., Kallas, T., Agostini, F., Wernersson, E., Spanjaard, B., Mota, A., Kolbeinsdottir, S., Gelali, E., Crosetto, N. and Bienko, M.
Nature Biotechnology 38
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October 2020
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Poh, J., Ponsford, A.H., Boyd, J., Woodsmith, J., Stelzl, U., Wanker, E., Harper, N., MacEwan, D. and Sanderson, C.M.
Redox Biology 37
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October 2020
Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
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Developmental Cell 54
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28 September 2020
Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B., Schmidt, M., Weisbach, H., Gruska, I., Vetter, B., Imami, K., Ostermann, E., Brune, W., Selbach, M., Hagemeier, C. and Wiebusch, L.
Nature Communications 11
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24 September 2020
Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O., Bullinger, L., Thiede, C., Flörcken, A., Westermann, J., Ehninger, G., Ho, A.D., Müller-Tidow, C., Gu, Z., Herrmann, C., Krijgsveld, J., Trumpp, A. and Hansson, J.
Blood 136
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24 September 2020
SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N., Taberner, F.J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K.K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S.G., Nawroth, P.P., Lewin, G.R. and Kuner, R.
Neuron 107
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23 September 2020
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H., Meyerson, W.U., Dursi, L.J., Wang, L.B., Dong, G., Liang, W.W., Weerasinghe, A., Li, S., Li, Y., Kelso, S., Saksena, G., Ellrott, K., Wendl, M.C., Wheeler, D.A., Getz, G., Simpson, J.T., Gerstein, M.B. and Ding, Li
Nature Communications 11
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21 September 2020
Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B., Alonso, G., Georgana, I., El-Jesr, M., Martín, R., Shair, K.H.Y., Fischer, C., Sauer, S., Maluquer de Motes, C. and Alcamí, A.
Science Advances 6
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18 September 2020
Optical mapping of cAMP signaling at the nanometer scale.
Bock, A., Annibale, P., Konrad, C., Hannawacker, A., Anton, S.E., Maiellaro, I., Zabel, U., Sivaramakrishnan, S., Falcke, M. and Lohse, M.J.
Cell 182
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17 September 2020
Oxidative metabolism drives immortalization of neural stem cells during tumorigenesis.
Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, M.D., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, R.P. and Knoblich, J.A.
Cell 182
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17 September 2020
Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
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Cell 182
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17 September 2020
Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling.
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Cell 182
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17 September 2020
Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El-Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., Lenz, C., Salinas, G., Diecke, S., Müller, C., Adham, I., Altmüller, J., Nürnberg, P., Paul, T., Zimmermann, W.H., Hasenfuss, G., Wollnik, B. and Cyganek, L.
Circulation 142
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15 September 2020
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf, R.Z., Saez, B., Sharda, A., van Gastel, N., Yu, V.W.C., Baryawno, N., Scadden, E.W., Acharya, S., Chattophadhyay, S., Huang, C., Viswanathan, V., S'aulis, D., Cobert, J., Sykes, D.B., Keibler, M.A., Das, S., Hutchinson, J.N., Churchill, M., Mukherjee, S., Lee, D., Mercier, F., Doench, J., Bullinger, L., Logan, D.J., Schreiber, S., Stephanopoulos, G., Rizzo, W.B. and Scadden, D.T.
Blood 136
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10 September 2020
Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W., Shang, F., Wang, X., Fanti, A.K., Greco, A., Busch, K., Klapproth, K., Zhang, Q., Quedenau, C., Sauer, S., Feyerabend, T.B., Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27
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3 September 2020
Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C., Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M.G., Perriello, V.M., Rasko, T., Alberti, G., Magnani, C.F., Cappuzzello, C., Lundberg, F., Pande, A., Dastoli, G., Introna, M., Serafini, M., Biagi, E., Izsvák, Z., Biondi, A. and Tettamanti, S.
Molecular Therapy 28
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2 September 2020
Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A., Carlo-Spiewok, A.S., Malik, A.R., Rothe, M., Schipke, C.G., Peters, O., Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 16
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September 2020
Blood pressure and angiogenic markers in pregnancy: contributors to pregnancy-induced hypertension and offspring cardiovascular risk.
Birukov, A.., Herse, F., Nielsen, J.H., Kyhl, H.B., Golic, M., Kräker, K., Haase, N., Busjahn, A., Bruun, S., Jensen, B.L., Müller, D.N., Jensen, T.K., Christesen, H.T., Andersen, M.S., Jørgensen, J.S., Dechend, R. and Andersen, L.B.
Hypertension 76
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September 2020
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J., Isbilir, A., Sungkaworn, T., Osberg, B., Karathanasis, C., Sunkara, V., Grushevskyi, E.O., Bock, A., Annibale, P., Heilemann, M., Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16
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September 2020
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M., Alpaugh, M., Sciacca, G., Saint-Pierre, M., Masnata, M., Denis, H.L., Lévesque, S.A., Herrmann, F., Bazenet, C., Garneau, A.P., Isenring, P., Truant, R., Oueslati, A., Gould, P.V., Ast, A., Wanker, E.E., Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 26
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September 2020
A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I., Beaton, N., Bruderer, R., Knobloch, T., Barbisan, C., Chandat, L., Sudau, A., Siepe, I., Rinner, O., de Souza, N., Picotti, P. and Reiter, L.
Nature Communications 11
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21 August 2020
Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L., Panayotis, N., Alber, S., Dagan, S.Y., Okladnikov, N., Koppel, I., Di Pizio, A., Song, D.A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M. and Fainzilber, M.
Science 369
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14 August 2020
Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L., Klaus, A., Maas, J., Morin-Poulard, I., Weijts, B., Schulte-Merker, S., Berezikov, E., Junker, J.P. and Robin, C.
Blood 136
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13 August 2020
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Biederstädt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H.P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G. and Keller, U.
Gut 69
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August 2020
Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L., Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27
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August 2020
High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Hehlmann, R., Voskanyan, A., Lauseker, M., Pfirrmann, M., Kalmanti, L., Rinaldetti, S., Kohlbrenner, K., Haferlach, C., Schlegelberger, B., Fabarius, A., Seifarth, W., Spieß, B., Wuchter, P., Krause, S., Kolb, H.J., Neubauer, A., Hossfeld, D.K., Nerl, C., Gratwohl, A., Baerlocher, G.M., Burchert, A., Brümmendorf, T.H., Hasford, J., Hochhaus, A., Saußele, S. and Baccarani, M.
Leukemia 34
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August 2020
Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M., Ferreira, D.G., Batalha, V.L., Marques-Morgado, I., Coelho, J.E., Pereira, P., Gomes, R., Pinto, A., Carvalho, S., Canas, P.M., Cuvelier, L., Buée-Scherrer, V., Faivre, E., Baqi, Y., Müller, C.E., Pimentel, J., Schiffmann, S.N., Buée, L., Bader, M., Outeiro, T.F., Blum, D., Cunha, R.A., Marie, H., Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25
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August 2020
Norman M. Kaplan: January 2, 1931-April 5, 2020.
Townsend, R.R., DiPette, D.J., Luft, F.C., Weinberger, M.H. and Ram, V.
Hypertension 76
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August 2020
Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
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Genome Biology 21
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29 July 2020
Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
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23 July 2020
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
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Nature Communications 11
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20 July 2020
Phosphodiesterase 3A and arterial hypertension.
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Circulation 142
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14 July 2020
Deep learning for genomics using Janggu.
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Nature Communications 11
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13 July 2020
Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
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Journal of Experimental Medicine 217
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6 July 2020
Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
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Nature Communications 11
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3 July 2020
VarFish: comprehensive DNA variant analysis for diagnostics and research.
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Nucleic Acids Research 48
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2 July 2020
Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
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July 2020
AP-1 imprints a reversible transcriptional programme of senescent cells.
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Nature Cell Biology 22
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July 2020
Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas.
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Cold Spring Harbor Perspectives in Biology 12
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July 2020
Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
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Journal of the American Society of Nephrology 31
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July 2020
Dynamic conjugate F-SHARP microscopy.
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30 June 2020
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
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23 June 2020
Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
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Nature Communications 11
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19 June 2020
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
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9 June 2020
The sensory coding of warm perception.
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3 June 2020
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
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Journal of Clinical Investigation 130
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1 June 2020
Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
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JAMA Oncology 6
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June 2020
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
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Nature Biomedical Engineering 4
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June 2020
Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes.
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June 2020
Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
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Nature Biotechnology 38
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June 2020
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
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Nature Protocols 15
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June 2020
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
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21 May 2020
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
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19 May 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
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4 May 2020
Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
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Nature Immunology 21
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May 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
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May 2020
Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.
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May 2020
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
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Nature Medicine 26
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May 2020
C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
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Cell Stem Cell 26
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May 2020
Integrative functional genomics decodes herpes simplex virus 1.
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Nature Communications 11
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27 April 2020
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
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Nature Communications 11
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24 April 2020
Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N., McKenzie, S., Beed, P., English, D.F., Oldani, S., Tukker, J.J., Buzsáki, G. and Schmitz, D.
Nature Communications 11
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23 April 2020
Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M., Ruiz-Orera, J., Albà, M.M. and Eyras, E.
Nature Communications 11
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14 April 2020
B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
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1 April 2020
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
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Journal of Allergy and Clinical Immunology 145
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April 2020
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
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Nature Cell Biology 22
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April 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
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Proceedings of the National Academy of Sciences of the United States of America 117
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31 March 2020
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
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Molecular Cell 77
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19 March 2020
Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
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Cell 180
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19 March 2020
FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L., Liang, H., Zhang, H., Yang, M.Z., Sun, W., Zhang, P., Luo, L., Feng, J.X., Bai, H., Liu, F., Zhang, T., Yang, J.Y., Gao, Q., Long, Y., Ma, X.Y., Chen, Y., Zhong, Q., Yu, B., Liao, S., Wang, Y., Zhao, Y., Zeng, M.S., Cao, N., Wang, J., Chen, W., Yang, H.T. and Gao, S.
Nucleic Acids Research 48
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18 March 2020
The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T., Schmid, M., Dou, Y., Garland, W., Milek, M., Imami, K., Johnsen, D., Polak, P., Andersen, J.S., Selbach, M., Landthaler, M. and Jensen, T.
Nucleic Acids Research 48
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18 March 2020
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
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Nature Communications 11
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10 March 2020
CRISPLD1: a novel conserved target in the transition to human heart failure.
Khadjeh, S., Hindmarsh, V., Weber, F., Cyganek, L., Vidal, R.O., Torkieh, S., Streckfuss-Bömeke, K., Lbik, D., Tiburcy, M., Mohamed, B.A., Bonn, S., Toischer, K. and Hasenfuss, G.
Basic Research in Cardiology 115
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7 March 2020
Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
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Circulation 141
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3 March 2020
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort.
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Clinical Gastroenterology and Hepatology 18
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March 2020
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80
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March 2020
Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability.
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Annals of Neurology 87
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March 2020
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
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Nature Genetics 52
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March 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11
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20 February 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11
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17 February 2020
Pan-cancer analysis of whole genomes.
Nature 578
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6 February 2020
Genomic basis for RNA alterations in cancer.
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6 February 2020
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6 February 2020
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
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Nature Communications 11
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5 February 2020
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
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Journal of Cachexia Sarcopenia and Muscle 11
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February 2020
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
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21 January 2020
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Nature Communications 11
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17 January 2020
A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
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Molecular Cell 77
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16 January 2020
Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
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Nature Communications 11
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10 January 2020
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
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8 January 2020
A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
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1 January 2020
Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
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January 2020
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Nature Genetics 52
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January 2020
Statins reverse postpartum cardiovascular dysfunction in a rat model of preeclampsia.
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January 2020
Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
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January 2020
Phosphorylation of RAB7 by TBK1/IKKε regulates innate immune signaling in triple negative breast cancer.
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January 2020
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January 2020
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Nature Communications 10
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18 December 2019
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5 December 2019
The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
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Nature Communications 10
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4 December 2019
Long-term effects of Na(+)/Ca(2+) exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
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December 2019
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
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December 2019
Gene expression changes and community turnover differentially shape the global ocean metatranscriptome.
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14 November 2019
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
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14 November 2019
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Nature Communications 10
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1 November 2019
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
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Nature Communications 10
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25 October 2019
Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
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21 October 2019
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
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18 October 2019
Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
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Nature Communications 10
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15 October 2019
A clonal expression biomarker associates with lung cancer mortality.
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Nature Medicine 25
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October 2019
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
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Nature Medicine 25
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October 2019
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
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Nature Medicine 25
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October 2019
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
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Nature Communications 10
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25 September 2019
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
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16 September 2019
Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
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Nature Communications 10
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16 September 2019
Widespread translational control of fibrosis in the human heart by RNA-binding proteins.
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Circulation 140
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10 September 2019
Antibiotics-induced monodominance of a novel gut bacterial order.
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9 September 2019
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
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Molecular Cell 75
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5 September 2019
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
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Nature Methods 16
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September 2019
FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
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Nature Methods 16
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September 2019
Maximizing binary interactome mapping with a minimal number of assays.
Choi, S.G., Olivet, J., Cassonnet, P., Vidalain, P.O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E.P., Janin, Y.L., van der Werf, S., Trepte, P., Wanker, E.E., De Las Rivas, J., Tavernier, J., Twizere, J.C., Hao, T., Hill, D.E., Vidal, M., Calderwood, M.A. and Jacob, Y.
Nature Communications 10
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29 August 2019
Postnatal Tshz3 deletion drives altered corticostriatal function and autism spectrum disorder-like behavior.
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15 August 2019
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
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Nature 572
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15 August 2019
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
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Nature Communications 10
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9 August 2019
Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
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August 2019
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
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Nature 571
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18 July 2019
Genetics of intellectual disability in consanguineous families.
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