High Impact Publications (Impact Factor > 10)

Article

Evaluating large language model workflows in clinical decision support for triage and referral and diagnosis.
Gaber, F., Shaik, M., Allega, F., Bilecz, A.J., Busch, F., Goon, K., Franke, V. and Akalin, A.
NPJ Digital Medicine 8 (1): 263. 9 May 2025

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.
Forster, P.M., Jakob, M.O., Yusuf, D., Bubeck, M., Limberger, H., Luo, Y., Thieme, P., Polici, A., Sterczyk, N., Boulekou, S., Bartel, L., Cosovanu, C., Witkowski, M., González-Acera, M., Kühl, A.A., Weidinger, C., Backofen, R., Hegazy, A.N., Patankar, J.V. and Klose, C.S.N.
Neuron 113 (9): 1333-1351. 7 May 2025

Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment.
Lv, W., Zeng, Y., Li, C., Liang, Y., Tao, H., Zhu, Y., Sui, X., Li, Y., Jiang, S., Gao, Q., Rodriguez-Fos, E., Prasad, G., Wang, Y., Zhou, R., Xu, Z., Pan, X., Chen, L., Xiang, X., Teng, H., Sun, C., Qin, T., Dong, W., Li, Y., Lan, X., Li, X., Lin, L., Bolund, L., Yang, H., Verhaak, R.G.W., Faltas, B.M., Hansen, J.B., Wu, S., Mischel, P.S., Henssen, A.G., Bafna, V., Luebeck, J., Regenberg, B., Luo, Y., Lin, C. and Han, P.
Cancer Discovery : OF1-OF22. 7 May 2025 (In Press)

Enhancing biomarker based oncology trial matching using large language models.
Al Khoury, N., Shaik, M., Wurmus, R. and Akalin, A.
NPJ Digital Medicine 8 (1): 250. 6 May 2025

Heart failure and obesity: translational approaches and therapeutic perspectives. A scientific statement of the Heart Failure Association of the ESC.
Savarese, G., Schiattarella, G.G., Lindberg, F., Anker, M.S., Bayes-Genis, A., Bäck, M., Braunschweig, F., Bucciarelli-Ducci, C., Butler, J., Cannata, A., Capone, F., Chioncel, O., D'Elia, E., González, A., Filippatos, G., Girerd, N., Hulot, J.S., Lam, C.S.P., Lund, L.H., Maack, C., Moura, B., Petrie, M.C., Piepoli, M., Shehab, A., Yilmaz, M.B., Seferovic, P., Tocchetti, C.G., Rosano, G.M.C. and Metra, M.
European Journal of Heart Failure 6 May 2025 (In Press)

Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration.
Heuberger, J., Liu, L., Berger, H., van den Heuvel, J., Lin, M., Müllerke, S., Bayram, S., Beccaceci, G., de Jonge, H., Gherardi, E. and Sigal, M.
Nature Communications 16 (1): 4131. 3 May 2025

Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire.
Rosenberger, L., Hansmann, L., Anastasopoulou, V., Wolf, S.P., Drousch, K., Moewes, C., Feng, X., Cao, G., Huang, J., Yew, P.Y., Strønen, E., Kato, T., Saligrama, N., Olweus, J., Nakamura, Y., Willimsky, G., Blankenstein, T., Schreiber, H. and Leisegang, M.
Journal for ImmunoTherapy of Cancer 13 (5): e011351. 2 May 2025

Preclinical in vitro and in vivo evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas.
Costanza, M., Giordano, C., von Brünneck, A.C., Zhao, J., Makky, A., Vinh, K., Montes-Mojarro, I.A., Reisinger, F., Forchhammer, S., Witalisz-Siepracka, A., Edtmayer, S., Stoiber, D., Yin, G., Horst, D., Fischer, A., Siebert, R., Nicolay, J.P., Yin, M., Janz, M., Fend, F., Becker, J.C., Schürch, C.M., Kenner, L., Assaf, C., Merkel, O. and Mathas, S.
British Journal of Dermatology 192 (5): 883-895. May 2025

Sex-specific association of myocardial fibrosis with mortality in patients with aortic stenosis.
Kwak, S., Singh, A., Everett, R.J., Treibel, T.A., Lim, J., Won, S., Williams, M.C., Loganathan, K., Bing, R., Craig, N., Singh, T., Joshi, S., Lee, H., Lee, W., Kim, Y.J., Chin, C.W.L., Fukui, M., Al Musa, T., Rigolli, M., Tastet, L., Dobson, L.E., Wiesemann, S., Ferreira, V.M., Captur, G., Lee, S., Schulz-Menger, J., Schelbert, E.B., Clavel, M.A., Park, S.J., Pellegrini, C., Hadamitzky, M., Gerber, B.L., Newby, D.E., Myerson, S.G., Pibarot, P., Cavalcante, J.L., McCann, G.P., Greenwood, J.P., Moon, J.C., Dweck, M.R. and Lee, S.P.
JAMA Cardiology 10 (5): 446-455. May 2025

Natural genetic variation quantitatively regulates heart rate and dimension.
Gierten, J., Welz, B., Fitzgerald, T., Thumberger, T., Agarwal, R., Hummel, O., Leger, A., Weber, P., Naruse, K., Hassel, D., Hübner, N., Birney, E. and Wittbrodt, J.
Nature Communications 16 (1): 4062. 30 April 2025

Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration.
Constanty, F., Wu, B., Wei, K.H., Lin, I.T., Dallmann, J., Guenther, S., Lautenschlaeger, T., Priya, R., Lai, S.L., Stainier, D.Y.R. and Beisaw, A.
Nature Communications 16 (1): 3823. 23 April 2025

CRISPR-Cas9 mediated proteinase 3 autoantigen deletion as a treatment strategy for anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
Jerke, U., Eulenberg-Gustavus, C., Wagner, D.L., Schreiber, A. and Kettritz, R.
Kidney International 21 April 2025 (In Press)

Helmholtz Health task force to strengthen prevention research and its translation globally.

Nature Medicine 18 April 2025 (In Press)

Patterns and drivers of diatom diversity and abundance in the global ocean.
Pierella Karlusich, J.J., Cosnier, K., Zinger, L., Henry, N., Nef, C., Bernard, G., Scalco, E., Dvorak, E., Vieira, F.R.J., Delage, E., Chaffron, S., Ovchinnikov, S., Zingone, A. and Bowler, C.
Nature Communications 16 (1): 3452. 11 April 2025

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses.
Lesbats, J., Brillac, A., Reisz, J.A., Mukherjee, P., Lhuissier, C., Fernández-Monreal, M., Dupuy, J.W., Sequeira, A., Tioli, G., De La Calle Arregui, C., Pinson, B., Wendisch, D., Rousseau, B., Efeyan, A., Sander, L.E., D'Alessandro, A. and Garaude, J.
Nature 640 (8058): 524-533. 10 April 2025

Comparing functional and genomic-based precision medicine in blood cancer patients.
Kazianka, L., Pichler, A., Agreiter, C., Rohrbeck, J., Kornauth, C., Porpaczy, E., Sillaber, C., Sperr, W.R., Gleixner, K.V., Hauswirth, A., Jäger, U., Valent, P., Jonak, C., Porkert, S., Exner, R., Willenbacher, W., Wolf, D., Neumeister, P., Prochazka, K., Deutsch, A., Greil, R., Schmitt, C., Ristl, R., Mayerhoefer, M., Simonitsch-Klupp, I., Pemovska, T. and Staber, P.B.
HemaSphere 9 (4): e70129. April 2025

DuplexDiscoverer: a computational method for the analysis of experimental duplex RNA-RNA interaction data.
Semenchenko, E., Tsybulsky, V. and Meyer, I.M.
Nucleic Acids Research 53 (7): gkaf266. April 2025

Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control.
Belenki, D., Richter-Pechanska, P., Shao, Z., Bhattacharya, A., Lau, A., de Freitas, J.A.N.L.F., Kandler, G., Hick, T.P., Cai, X., Scharnagl, Eva, Bittner, A., Schönlein, M., Kase, J., Pardon, K., Brzezicha, B., Thiessen, N., Bischof, O., Dörr, J.R., Reimann, M., Milanovic, M., Du, J., Yu, Y., Chapuy, B., Lee, S., Leser, U., Scheidereit, C., Wolf, J., Fan, D.N.Y. and Schmitt, C.A.
Nature Communications 16 (1): 3079. 31 March 2025

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.
Al Bakir, M., Reading, J.L., Gamble, S., Rosenthal, R., Uddin, I., Rowan, A., Przewrocka, J., Rogers, A., Wong, Y.N.S., Bentzen, A.K., Veeriah, S., Ward, S., Garnett, A.T., Kalavakur, P., Martínez-Ruiz, C., Puttick, C., Huebner, A., Cook, D.E., Moore, D.A., Abbosh, C., Hiley, C.T., Naceur-Lombardelli, C., Watkins, T.B.K., Petkovic, M., Schwarz, R.F., Gálvez-Cancino, F., Litchfield, K., Meldgaard, P., Sorensen, B.S., Madsen, L.B., Jäger, D., Forster, M.D., Arkenau, T., Domingo-Vila, C., Tree, T.I.M., Kadivar, M., Hadrup, S.R., Chain, B., Quezada, S.A., McGranahan, N. and Swanton, C.
Nature 639 (639): 639. 27 March 2025

A proteogenomic view of synchronous endometrioid endometrial and ovarian cancer.
Coscia, F., Nielsen, A.B., Weigert, M., Watters, K., Javellana, M., Anglesio, M., Yamada, S.D., Lastra, R.R., Mann, M. and Lengyel, E.
Clinical Cancer Research 27 March 2025 (In Press)

Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3.
Chen, K.Y., Kibayashi, T., Giguelay, A., Hata, M., Nakajima, S., Mikami, N., Takeshima, Y., Ichiyama, K., Omiya, R., Ludwig, L.S., Hattori, K. and Sakaguchi, S.
Nature 26 March 2025 (In Press)

XBP1s-EDEM2 prevents the onset and development of HFpEF by ameliorating cardiac lipotoxicity.
Fonseka, O., Raja, R., Ross, C., Gare, S.R., Zhang, J., Hille, S.S., King, K., Ruiz-Velasco, A., Kaur, N., Chen, X., Miller, J.M., Abouleisa, R.R.E., Ou, Q., Zou, Z., Zhao, X., Sotomayor-Flores, C., Frank, D., Swanton, E., Pool, M.R., Missaglia, S., Tavian, D., Schiattarella, G.G., Wang, T., Venetucci, L., Pinali, C., Rutter, M.K., Keavney, B.D., Cartwright, E.J., Mohamed, T.M.A., Müller, O.J. and Liu, W.
Circulation 25 March 2025 (In Press)

Engineered heart muscle allografts for heart repair in primates and humans.
Jebran, A.F., Seidler, T., Tiburcy, M., Daskalaki, M., Kutschka, I., Fujita, B., Ensminger, S., Bremmer, F., Moussavi, A., Yang, H., Qin, X., Mißbach, S., Drummer, C., Baraki, H., Boretius, S., Hasenauer, C., Nette, T., Kowallick, J., Ritter, C.O., Lotz, J., Didié, M., Mietsch, M., Meyer, T., Kensah, G., Krüger, D., Sakib, M.S., Kaurani, L., Fischer, A., Dressel, R., Rodriguez-Polo, I., Stauske, M., Diecke, S., Maetz-Rensing, K., Gruber-Dujardin, E., Bleyer, M., Petersen, B., Roos, C., Zhang, L., Walter, L., Kaulfuß, S., Yigit, G., Wollnik, B., Levent, E., Roshani, B., Stahl-Henning, C., Ströbel, P., Legler, T., Riggert, J., Hellenkamp, K., Voigt, J.U., Hasenfuß, G., Hinkel, R., Wu, J.C., Behr, R. and Zimmermann, W.H.
Nature 639 (8054): 503-511. 13 March 2025

Myeloid fatty acid metabolism activates neighboring hematopoietic stem cells to promote heart failure with preserved ejection fraction.
Filipp, M., Ge, Z.D., DeBerge, M., Lantz, C., Glinton, K., Gao, P., Smolgovsky, S., Dai, J., Zhao, Y.Y., Yvan-Charvet, L., Alcaide, P., Weinberg, S.E., Schiattarella, G.G., Hill, J.A., Feinstein, M.J., Shah, S.J. and Thorp, E.B.
Circulation 12 March 2025 (In Press)

Circulating extracellular vesicles as putative mediators of cardiovascular disease in paediatric chronic kidney disease.
Behrens, F., Holle, J., Chen, C.Y., Ginsbach, L.F., Krause, B.C., Bruning, U., Kriegel, F.L., Kaiser, T., Szijártó, I.A., Anandakumar, H., Lehmann, K., Schumacher, F., Durek, P., Heinrich, F.F., Lodka, D., Hoffmann, C., Borchardt, A.A., Peters, L., Michalick, L., Querfeld, U., Bufler, P., Luch, A., Kleuser, B., Kirwan, J.A., Forslund, S.K., Thumfahrt, J., Müller, D., Wilck, N., Mashreghi, M.F., Löber, U., Bartolomaeus, H., Kuebler, W.M. and Simmons, S.
Journal of Extracellular Vesicles 14 (3): e70062. March 2025

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer.
Bentham, R., Jones, T.P., Black, J.R.M., Martinez-Ruiz, C., Dietzen, M., Litovchenko, M., Thol, K., Watkins, T.B.K., Bailey, C., Pich, O., Zhang, Z., Van Loo, P., Swanton, C. and McGranahan, N.
Nature Genetics 57 (3): 694-705. March 2025

Rapid brain tumor classification from sparse epigenomic data.
Brändl, B., Steiger, M., Kubelt, C., Rohrandt, C., Zhu, Z., Evers, M., Wang, G., Schuldt, B., Afflerbach, A.K., Wong, D., Lum, A., Halldorsson, S., Djirackor, L., Leske, H., Magadeeva, S., Smičius, R., Quedenau, C., Schmidt, N.O., Schüller, U., Vik-Mo, E.O., Proescholdt, M., Riemenschneider, M.J., Zadeh, G., Ammerpohl, O., Yip, S., Synowitz, M., van Bömmel, A., Kretzmer, H. and Müller, F.J.
Nature Medicine 31 (3): 840-848. March 2025

The non-canonical proteome: a novel contributor to cancer proliferation.
Ruiz-Orera, J. and Hübner, N.
Cell Research 35 (3): 155-156. March 2025

Mucosal washes are useful for sampling intestinal mucus-associated microbiota despite low biomass.
Martinez-Medina, J.N., Ghazisaeedi, F., Kramer, C., Ziegler, J.F., McParland, V., Mönch, P.W., Siegmund, B., Jarquín-Díaz, V.H., Fulde, M. and Forslund-Startceva, S.K.
Gut Microbes 17 (1): 2464296. 20 February 2025

Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.
Giese, W., Albrecht, J.P., Oppenheim, O., Akmeriç, E.B., Kraxner, J., Schmidt, D., Harrington, K.I. and Gerhardt, H.
Nature Communications 16 (1): 1474. 8 February 2025

Protein kinase A regulates ferroptosis by controlling GPX4 m(6)A modification through phosphorylation of ALKBH5.
Zhao, X., Sun, Y., Zou, J., Wu, Y., Huang, M., Kong, H., Liu, G., Gerhardt, H., Gu, W., Zhang, Y., Shang, M. and Wang, X.
Cell Death and Differentiation 3 February 2025 (In Press)

Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing.
Abay, T., Stickels, R.R., Takizawa, M.T., Nalbant, B.N., Hsieh, Y.H., Hwang, S., Snopkowski, C., Yu, K.K.H., Abou-Mrad, Z., Tabar, V., Howitt, B.E, Ludwig, L.S., Chaligné, R., Satpathy, A.T and Lareau, C.A.
Nature Genetics 57 (2): 451-460. February 2025

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B., Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T., Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D., Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology 168 (2): 327-343. February 2025

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma.
Lutz, R., Poos, A.M., Solé-Boldo, L., John, L., Wagner, J., Prokoph, N., Baertsch, M.A., Vonficht, D., Palit, S., Brobeil, A., Mechtersheimer, G., Hildenbrand, N., Hemmer, S., Steiger, S., Horn, S., Pepke, W., Spranz, D.M., Rehnitz, C., Sant, P., Mallm, J.P., Friedrich, M.J., Reichert, P., Huhn, S., Trumpp, A., Rippe, K., Haghverdi, L., Fröhling, S., Müller-Tidow, C., Hübschmann, D., Goldschmidt, H., Willimsky, G., Sauer, S., Raab, M.S., Haas, S. and Weinhold, N.
Science Immunology 10 (104): eadp6667. February 2025

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
Mzoughi, S., Schwarz, M., Wang, X., Demircioglu, D., Ulukaya, G., Mohammed, K., Zorgati, H., Torre, D., Tomalin, L.E., Di Tullio, F., Company, C., Dramaretska, Y., Leushacke, M., Giotti, B., Lannagan, T.R., Lozano-Ojalvo, D., Karras, P., Vermeulen, P.B., Hasson, D., Sebra, R., Tsankov, A.M., Sansom, O.J., Marine, J.C., Barker, N., Gargiulo, G. and Guccione, E.
Nature Genetics 57 (2): 402-412. February 2025

Genetic alterations, therapy response, and survival among patients with triple-negative breast cancer: a secondary analysis of a randomized clinical trial.
Richters, L., Gluz, O., Weber-Lassalle, N., Christgen, M., Haverkamp, H., Kuemmel, S., Kayali, M., Kates, R.E., Grischke, E.M., Altmüller, J., Forstbauer, H., Thiele, H., Braun, M., Warm, M., Ossowski, A., Wuerstlein, R., Ernst, C., Graeser, M., Linn, S.C., Nitz, U., Hauke, J., Kreipe, H.H., Schmutzler, R.K., Hahnen, E. and Harbeck, N.
JAMA Network Open 8 (2): e2461639. February 2025

The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes.
Eibach, Y., Kreher, S., Poetsch, M.S., Kho, A.L., Gaertner, U., Clemen, C.S., Schröder, R., Guo, K., Milting, H., Meder, B., Potente, M., Richter, M., Schneider, A., Meiners, S., Gaute, M. and Braun, T.
Science Advances 11 (4): eado3852. 24 January 2025

Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín, A., Pineda-Santaella, A., Martín-García, R., Esteban-Villafañe, R., Matarrese, A., Pinto-Cruz, J., Camacho-Cabañas, S., León-Periñán, D., Terrizzano, A., Daga, R.R., Braun, S. and Fernández-Álvarez, A.
Nature Communications 16 (1): 837. 20 January 2025

RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses.
Kabrani, E., Rahjouei, A., Berruezo-Llacuna, M., Ebeling, S., Saha, T., Altwasser, R., Delgado-Benito, V., Pavri, R. and Di Virgilio, M.
Nature Communications 16 (1): 777. 17 January 2025

Herpesviruses mimic zygotic genome activation to promote viral replication.
Neugebauer, E., Walter, S., Tan, J., Drayman, N., Franke, V., van Gent, M., Pennisi, S., Veratti, P., Stein, K.S., Welker, I., Tay, S., Verjans, G.M.G.M., Timmers, H.T.M., Akalin, A., Landthaler, M., Ensser, A., Wyler, E. and Full, F.
Nature Communications 16 (1): 710. 16 January 2025

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Avery, E.G., Haag, L.M., McParland, V., Kedziora, S.M., Zigra, G.J., Valdes, D.S., Kirchner, M., Popp, O., Geisberger, S., Nonn, O., Karlsen, T.V., N'Diaye, G., Yarritu, A., Bartolomaeus, H., Bartolomaeus, T.U.P., Tagiyeva, N.A., Wimmer, M.I., Haase, N., Zhang, Y.D., Wilhelm, A., Grütz, G., Tenstad, O., Wilck, N., Forslund, S.K., Klopfleisch, R., Kühl, A.A., Atreya, R., Kempa, S., Mertins, P., Siegmund, B., Wiig, H. and Müller, D.N.
Cardiovascular Research : cvae267. 13 January 2025 (In Press)

Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.
Wiechert, F., Unbehaun, A., Sprink, T., Seibel, H., Bürger, J., Loerke, J., Mielke, T., Diebolder, C.A., Schacherl, M. and Spahn, C.M.T.
Nucleic Acids Research 53 (1): gkae1191. 13 January 2025

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Lauer, S.M., Gasse, J., Krizsan, A., Reepmeyer, M., Sprink, T., Nikolay, R., Spahn, C.M.T. and Hoffmann, R.
Nature Communications 16 (1): 567. 10 January 2025

TERT expression and clinical outcome in pulmonary carcinoids.
Werr, L., Bartenhagen, C., Rosswog, C., Cartolano, M., Voegele, C., Sexton-Oates, A., Di Genova, A., Ernst, A., Kahlert, Y., Hemstedt, N., Höppner, S., Mansuet Lupo, A., Pelosi, G., Brcic, L., Papotti, M., George, J., Bosco, G., Quaas, A., Tang, L.H., Robzyk, K., Kadota, K., Roh, M.S., Fanaroff, R.E., Falcon, C.J., Büttner, R., Lantuejoul, S., Rekhtman, N., Rudin, C.M., Travis, W.D., Alcala, N., Fernandez-Cuesta, L., Foll, M., Peifer, M., Thomas, R.K. and Fischer, M.
Journal of Clinical Oncology 43 (2): 214-225. 10 January 2025

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations.
Nishijima, S., Stankevic, E., Aasmets, O., Schmidt, T.S.B., Nagata, N., Keller, M.I., Ferretti, P., Juel, H.B., Fullam, A., Robbani, S.M., Schudoma, C., Hansen, J.K., Holm, L.A., Israelsen, M., Schierwagen, R., Torp, N., Telzerow, A., Hercog, R., Kandels, S., Hazenbrink, D.H.M., Arumugam, M., Bendtsen, F., Brøns, C., Fonvig, C.E., Holm, J.C., Nielsen, T., Pedersen, J.S., Thiele, M.S., Trebicka, J., Org, E., Krag, A., Hansen, T., Kuhn, M. and Bork, P.
Cell 188 (1): 222-236. 9 January 2025

The STRING database in 2025: protein networks with directionality of regulation.
Szklarczyk, D., Nastou, K., Koutrouli, M., Kirsch, R., Mehryary, F., Hachilif, R., Hu, D., Peluso, M.E., Huang, Q., Fang, T., Doncheva, N.T., Pyysalo, S., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 53 (D1): D730–D737. 6 January 2025

Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy.
Escobar, H., Di Francescantonio, S., Smirnova, J., Graf, R., Müthel, S., Marg, A., Zhogov, A., Krishna, S., Metzler, E., Petkova, M., Daumke, O., Kühn, R. and Spuler, S.
Nature Communications 16 (1): 120. 2 January 2025

Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease.
Bao, L.L., Yu, Y.Q., González-Acera, M., Patankar, J.V., Giessl, A., Sturm, G., Kühl, A.A., Atreya, R., Erkert, L., Gámez-Belmonte, R., Krug, S.M., Schmid, B., Tripal, P., Chiriac, M.T., Hildner, K., Siegmund, B., Wirtz, S., Stürzl, M., Mohamed Abdou, M., Trajanoski, Z., Neurath, M.F., Zorzano, A. and Becker, C.
Science Translational Medicine 17 (781): eadn8699. January 2025

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics.
Sakenova, N., Cacace, E., Orakov, A., Huber, F., Varik, V., Kritikos, G., Michiels, J., Bork, P., Cossart, P., Goemans, C.V. and Typas, A.
Nature Microbiology 10 (1): 202-216. January 2025

Lessons from a negative gene therapy trial for Duchenne muscular dystrophy.
Spuler, S., Borasio, G.D. and Grittner, U.
Nature Medicine 31 (1): 37-38. January 2025

Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription.
Cordero, J., Swaminathan, G., Rogel-Ayala, D.G., Rubio, K., Elsherbiny, A., Mahmood, S., Szymanski, W., Graumann, J., Braun, T., Günther, S., Dobreva, G. and Barreto, G.
Nature Communications 15 (1): 10711. 20 December 2024

Circulating tumor DNA sequencing for biologic classification and individualized risk stratification in patients with Hodgkin Lymphoma.
Heger, J.M., Mammadova, L., Mattlener, J., Sobesky, S., Cirillo, M., Altmüller, J., Kirst, E., Reinke, S., Klapper, W., Bröckelmann, P.J., Ferdinandus, J., Kaul, H., Schneider, G., Schneider, J., Schleifenbaum, J.K., Ullrich, R.T., Freihammer, M., Awerkiew, S., Lohmann, M., Klein, F., Nürnberg, P., Hallek, M., Rossi, D., Mauz-Körholz, C., Gattenlöhner, S., Bräuninger, A., Borchmann, P., von Tresckow, B. and Borchmann, S.
Journal of Clinical Oncology 42 (35): 4218-4230. 10 December 2024

Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova, D., Fritsch, V.N., Siebert, K., Methling, K., Lalk, M., Busche, T., Kalinowski, J., Weiner, J., Beule, D., Bertrams, W., Kohler, T.P., Hammerschmidt, S., Löwa, A., Fischer, M., Mieth, M., Hellwig, K., Frey, D., Neudecker, J., Rueckert, J.C., Toennies, M., Bauer, T.T., Graff, M., Tran, H.L., Eggeling, S., Gruber, A.D., Antelmann, H., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 64 (6): 2301983. December 2024

Non-viral targeted insertion of large payloads into T cells.
Izsvak, Z.
Nature Biomedical Engineering 8 (12): 1516-1517. December 2024

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
Leppä, A.M., Grimes, K., Jeong, H., Huang, F.Y., Andrades, A., Waclawiczek, A., Boch, T., Jauch, A., Renders, S., Stelmach, P., Müller-Tidow, C., Karpova, D., Sohn, M., Grünschläger, F., Hasenfeld, P., Benito Garagorri, E., Thiel, V., Dolnik, A., Rodriguez-Martin, B., Bullinger, L., Mrózek, K., Eisfeld, A.K., Krämer, A., Sanders, A.D., Korbel, J.O. and Trumpp, A.
Nature Genetics 56 (12): 2790-2803. December 2024

Interleukin 11 therapy causes acute left ventricular dysfunction.
Sweeney, M., O’Fee, K., Villanueva-Hayes, C., Rahman, E., Lee, M., Tam, C.N., Pascual-Navarro, E., Maatz, H., Lindberg, E.L., Vanezis, K., Ramachandra, C.J., Andrew, Iv., Jennings, E.R., Lim, W.W., Widjaja, A.A., Carling, D., Hausenloy, D.J., Hübner, N., Barton, P.J.R. and Cook, S.A.
Cardiovascular Research 120 (17): 2220-2235. December 2024

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy.
Lutz, R., Grünschläger, F., Simon, M., Awwad, M.H.S., Bauer, M., Yousefian, S., Beumer, N., Jopp-Saile, L., Sedlmeier, A., Solé-Boldo, L., Avanesyan, B., Vonficht, D., Stelmach, P., Steinbuss, G., Boch, T., Steiger, S., Baertsch, M.A., Prokoph, N., Rippe, K., Durie, B.G.M., Wickenhauser, C., Trumpp, A., Müller-Tidow, C., Hübschmann, D., Weinhold, N., Raab, M.S., Brors, B., Goldschmidt, H., Imbusch, C.D., Hundemer, M. and Haas, S.
Nature Communications 15 (1): 10396. 29 November 2024

New cardiovascular biomarkers in patients with advanced cancer – a prospective study comparing MR-proADM, MR-proANP, copeptin, high-sensitivity troponin T and NT-proBNP.
Anker, M.S., Lück, L.C., Khan, M.S., Porthun, J., Hadzibegovic, S., Lena, A., Wilkenshoff, U., Weinländer, P., Evertz, R., Totzeck, M., Mahabadi, A.A., Rassaf, T., Anker, S.D., Bullinger, L., Keller, U., Karakas, M., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure 26 November 2024 (In Press)

TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy.
Walther, W., Torke, S. and Stein, U.
Signal Transduction and Targeted Therapy 9 (1): 331. 26 November 2024

Sex-specific prediction of cardiogenic shock after acute coronary syndromes: the SEX-SHOCK score.
Wang, Y., Zeller, M., Auffret, V., Georgiopoulos, G., Räber, L., Roffi, M., Templin, C., Muller, O., Liberale, L., Ministrini, S., Stamatelopoulos, K., Stellos, K., Camici, G.G., Montecucco, F., Rickli, H., Maza, M., Radovanovic, D., Cottin, Y., Chague, F., Niederseer, D., Lüscher, T.F. and Kraler, S.
European Heart Journal 45 (43): 4564-4578. 14 November 2024

Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung, K.L., Jones, M.G., Wong, I.T.L., Curtis, E.J., Lange, J.T., He, B.J., Luebeck, J., Schmargon, R., Scanu, E., Brückner, L., Yan, X., Li, R., Gnanasekar, A., Chamorro González, R., Belk, J.A., Liu, Z., Melillo, B., Bafna, V., Dörr, J.R., Werner, B., Huang, W., Cravatt, B.F., Henssen, A.G., Mischel, P.S and Chang, H.Y.
Nature 635 (8037): 201-209. 7 November 2024

Modulating the mucosal drug delivery efficiency of polymeric nanogels tuning their redox response and surface charge.
Udabe, J., Muñoz‐Juan, A., Tafech, B., Orellano, M.S., Hedtrich, S., Laromaine, A. and Calderón, M.
Advanced Functional Materials 34 (45): 2407044. 5 November 2024

Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations.
Penter, L., Cieri, N., Maurer, K., Kwok, M., Lyu, H., Lu, W.S., Oliveira, G., Gohil, S.H., Leshchiner, I., Lareau, C.A., Ludwig, L.S., Neuberg, D.S., Kim, H.T., Li, S., Bullinger, L., Ritz, J., Getz, G., Garcia, J.S., Soiffer, R.J., Livak, K.J. and Wu, C.J.
Blood Cancer Discovery 5 (6): 442-459. 1 November 2024

Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study.
Derigs, P., Schubert, M.L., Dreger, P., Schmitt, A., Yousefian, S., Haas, S., Röthemeier, C., Neuber, B., Hückelhoven-Krauss, A., Brüggemann, M., Bernhard, H., Kobbe, G., Lindemann, A., Rummel, M., Michels, B., Korell, F., Ho, A.D., Müller-Tidow, C. and Schmitt, M.
Leukemia 38 (11): 2419-2428. November 2024

PITX2 deficiency leads to atrial mitochondrial dysfunction.
Reyat, J.S., Sommerfeld, L.C., O'Reilly, M., Cardoso, V.R., Thiemann, E., Khan, A.O., O'Shea, C., Harder, S., Müller, C., Barlow, J., Stapley, R.J., Chua, W., Kabir, S.N., Grech, O., Hummel, O., Hübner, N., Kääb, S., Mont, Ll., Hatem, S.N., Winters, J., Zeemering, S., Morgan, N.V., Rayes, J., Gehmlich, K., Stoll, M., Brand, T., Schweizer, M., Piasecki, A., Schotten, U., Gkoutos, G.V., Lorenz, K., Cuello, F., Kirchhof, P. and Fabritz, L.
Cardiovascular Research 120 (15): 1907-1923. November 2024

Emergence of community behaviors in the gut microbiota upon drug treatment.
Garcia-Santamarina, S., Kuhn, M., Devendran, S., Maier, L., Driessen, M., Mateus, A., Mastrorilli, E., Brochado, A.R., Savitski, M.M., Patil, K.R., Zimmermann, M., Bork, P. and Typas, A.
Cell 187 (22): 6346-6357.e20. 31 October 2024

p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10 (43): eadp8783. 25 October 2024

Amplification of autoimmune organ damage by NKp46-activated ILC1.
Biniaris-Georgallis, S.I., Aschman, T., Stergioula, K., Schreiber, F., Jafari, V., Taranko, A., Karmalkar, T., Kasapi, A., Lenac Rovis, T., Jelencic, V., Bejarano, D.A., Fabry, L., Papacharalampous, M., Mattiola, I., Molgora, M., Hou, J., Hublitz, K.W., Heinrich, F., Guerra, G.M., Durek, P., Patone, G., Lindberg, E.L.H., Maatz, H., Hölsken, O., Krönke, G., Mortha, A., Voll, R.E., Clarke, A.J., Hauser, A.E., Colonna, M., Thurley, K., Schlitzer, A., Schneider, C., Stamatiades, E.G., Mashreghi, M.F., Jonjic, S., Hübner, N., Diefenbach, A., Kanda, M. and Triantafyllopoulou, A.
Nature 634 (8035): 952-960. 24 October 2024

Structure, interaction and nervous connectivity of beta cell primary cilia.
Müller, A., Klena, N., Pang, S., Garcia, L.E.G., Topcheva, O., Aurrecoechea Duran, S., Sulaymankhil, D., Seliskar, M., Mziaut, H., Schöniger, E., Friedland, D., Kipke, N., Kretschmar, S., Münster, C., Weitz, J., Distler, M., Kurth, T., Schmidt, D., Hess, H.F., Xu, C.S., Pigino, G. and Solimena, M.
Nature Communications 15 (1): 9168. 24 October 2024

Mapping lineage-traced cells across time points with moslin.
Lange, M., Piran, Z., Klein, M., Spanjaard, B., Klein, D., Junker, J.P., Theis, F.J. and Nitzan, M.
Genome Biology 25 (1): 277. 21 October 2024

Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture.
Patsalos, A., Halasz, L., Oleksak, D., Wei, X., Nagy, G., Tzerpos, P., Conrad, T., Hammers, D.W., Sweeney, H.L. and Nagy, L.
Journal of Clinical Investigation 134 (20): e173858. 15 October 2024

Aggressive lymphoma after CD19 CAR T-cell therapy.
Kobbe, G., Brüggemann, M., Baermann, B.N., Wiegand, L., Trautmann, H., Yousefian, S., Libertini, S., Menssen, H.D., Maier, H.J., Ulrich, P., Gao, J., Bruch, P.M., Liebers, N., Radujkovic, A., Seifert, M., Schniederjohann, C., Paramasivam, N., Fitzgerald, D., Seidel, M., Esposito, I., Germing, U., Cadeddu, R.P., Nachtkamp, K., Jäger, P., Ulrych, T., Fischer, J.C., Rox, J.M., Giesel, F., Koch, R., Antoch, G., Distler, J.H.W., Meuth, S.G., Jacobsen, M., Hübschmann, D., Lu, J., Iaccarino, I., Haas, S., Damm, F. and Dietrich, S.
New England Journal of Medicine 391 (13): 1217-1226. 3 October 2024

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control.
Dobner, J., Diecke, S., Krutmann, J., Prigione, A. and Rossi, A.
Nature Communications 15 (1): 8547. 2 October 2024

MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.
Puttick, C., Jones, T.P., Leung, M.M., Galvez-Cancino, F., Liu, J., Varas-Godoy, M., Rowan, A., Pich, O., Martinez-Ruiz, C., Bentham, R., Dijkstra, K.K., Black, J.R.M., Rosenthal, R., Kanu, N., Litchfield, K., Salgado, R., Moore, D.A., Van Loo, P., Jamal-Hanjani, M., Quezada, S.A., Swanton, C. and McGranahan, N.
Nature Genetics 56 (10): 2121-2131. October 2024

Piezo2 voltage-block regulates mechanical pain sensitivity.
Sánchez-Carranza, O., Chakrabarti, S., Kühnemund, J., Schwaller, F., Bégay, V., García-Contreras, J.A., Wang, Lin and Lewin, G.R.
Brain 147 (10): 3487-3500. October 2024

Bifidobacterium and lactobacillus probiotics and gut dysbiosis in preterm infants: the PRIMAL randomized clinical trial.
Van Rossum, T., Haiß, A., Knoll, R.L., Marißen, J., Podlesny, D., Pagel, J., Bleskina, M., Vens, M., Fortmann, I., Siller, B., Ricklefs, I., Klopp, J., Hilbert, K., Meyer, C., Thielemann, R., Goedicke-Fritz, S., Kuntz, M., Wieg, C., Teig, N., Körner, T., Kribs, A., Hudalla, H., Knuf, M., Stein, A., Gille, C., Bagci, S., Dohle, F., Proquitté, H., Olbertz, D.M., Schmidt, E., Koch, L., Pirr, S., Rupp, J., Spiegler, J., Kopp, M.V., Göpel, W., Herting, E., Forslund, S.K., Viemann, D., Zemlin, M., Bork, P., Gehring, S., König, I.R., Henneke, P. and Härtel, C.
JAMA Pediatrics 178 (10): 985-995. October 2024

A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies.
Wirbel, J., Essex, M., Forslund, S.K. and Zeller, G.
Genome Biology 25 (1): 247. 25 September 2024

Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy.
Gross, S., Ihlow, J., Busack, L., Adamiak, K., Schrezenmeier, J., Jesse, J., Schwarz, M., Flörcken, A., Vuong, L.G., Rieger, K., Krönke, J., le Coutre, P., Boldt, V., von Brünneck, A.C., Horst, D., Burmeister, T., Blau, I.W., Keller, U., Bullinger, L. and Westermann, J.
Blood Cancer Journal 14 (1): 160. 16 September 2024

Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O., Kirchner, M., Mertins, P., Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57 (9): 2140-2156.e10. 10 September 2024

Cell swelling enhances ligand-driven β-adrenergic signaling.
Sirbu, A., Bathe-Peters, M., Kumar, J.L.M, Inoue, A., Lohse, M.J. and Annibale, P.
Nature Communications 15 (1): 7822. 7 September 2024

Deciphering the impact of genomic variation on function.

Nature 633 (8028): 47-57. 5 September 2024

Proteomic signatures improve risk prediction for common and rare diseases.
Carrasco-Zanini, J., Pietzner, M., Davitte, J., Surendran, P., Croteau-Chonka, D.C., Robins, C., Torralbo, A., Tomlinson, C., Grünschläger, F., Fitzpatrick, N., Ytsma, C., Kanno, T., Gade, S., Freitag, D., Ziebell, F., Haas, S., Denaxas, S., Betts, J.C., Wareham, N.J., Hemingway, H., Scott, R.A. and Langenberg, C.
Nature Medicine 30 (9): 2489-2498. September 2024

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T., Graf, R., Acevedo-Ochoa, E., Trombke, J., Weber, T., Sommermann, T., Salomon, C., Kühn, R., Rajewsky, K. and Chu, V.T.
Leukemia 38 (9): 2003-2015. September 2024

A catalog of small proteins from the global microbiome.
Duan, Y., Santos-Júnior, C.D., Schmidt, T.S., Fullam, A., de Almeida, B.L.S., Zhu, C., Kuhn, M., Zhao, X.M., Bork, P. and Coelho, L.P.
Nature Communications 15 (1): 7563. 31 August 2024

Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135 (6): 671-684. 30 August 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15 (1): 7027. 22 August 2024

Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B.D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K.P.L., Flüh, C., Kälin, R.E. and Glass, R.
Cell Reports Medicine 5 (8): 101658. 20 August 2024

Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts.
Lai, S., Wang, H., Bork, P., Chen, W.H. and Zhao, X.M.
Science Advances 10 (33): eadn3316. 16 August 2024

Lysozyme 1 inflamed CCR2(+) macrophages promote obesity-induced cardiac dysfunction.
Zhang, L., Han, H., Xu, A., Sathe, A., Fu, S., Zhao, J., Cai, W., Yang, Y., Liu, J., Bai, H., Ben, J., Zhu, X., Li, X., Yang, Q., Wang, Z., Gu, Y., Xing, C., Schiattarella, G.G., Cheng, S.Y., Zhang, H. and Chen, Q.
Circulation Research 135 (5): 596-613. 16 August 2024

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15 (1): 6851. 10 August 2024

Hif-2α programs oxygen chemosensitivity in chromaffin cells.
Prange-Barczynska, M., Jones, H.A., Sugimoto, Y., Cheng, X., Lima, J.D., Ratnayaka, I., Douglas, G., Buckler, K.J., Ratcliffe, P.J., Keeley, T.P. and Bishop, T.
Journal of Clinical Investigation 134 (18): e174661. 6 August 2024

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Widjaja, A.A., Lim, W.W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C.M., Goh, J.W.T., Lim, R., Singh, B.K., Tan, J., Pua, C.J., Lim, S.Y., Adami, E., Schafer, S., George, B.L., Sweeney, M., Xie, C., Tripathi, M., Sims, N.A., Hübner, N., Petretto, E., Withers, D.J., Ho, L., Gil, J., Carling, D. and Cook, S.A.
Nature 632 (8023): 157-165. 1 August 2024

Likelihood of post-COVID condition in people with hybrid immunity; data from the German National Cohort (NAKO).
Mikolajczyk, R., Diexer, S., Klee, B., Pfrommer, L., Purschke, O., Fricke, J., Ahnert, P., Gabrysch, S., Gottschick, C., Bohn, B., Brenner, H., Buck, C., Castell, S., Gastell, S., Greiser, K.H., Harth, V., Heise, J.K., Holleczek, B., Kaaks, R., Keil, T., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, Cl., Michels, K.B., Moreno Velásquez, I., Obi, N., Panreck, L., Peters, A., Pischon, T., Schikowski, T., Schmidt, B., Standl, M., Stang, A., Völzke, H., Weber, A., Zeeb, H. and Karch, A.
Journal of Infection 89 (2): 106206. August 2024

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5 (8): 1267-1284. August 2024

Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E., Lauber, C., Manukyan, A., Deter, A., Quedenau, C., Teixeira Alves, L.G., Wylezich, C., Borodina, T., Seitz, S., Altmüller, J. and Landthaler, M.
Environment International 190 : 108875. August 2024

Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts.
Kolesnichenko, M. and Scheidereit, C.
Signal Transduction and Targeted Therapy 9 (1): 179. 29 July 2024

Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial.
Borchmann, P., Ferdinandus, J., Schneider, G., Moccia, A., Greil, R., Hertzberg, M., Schaub, V., Hüttmann, A., Keil, F., Dierlamm, J., Hänel, M., Novak, U., Meissner, J., Zimmermann, A., Mathas, S., Zijlstra, J.M., Fosså, A., Viardot, A., Hertenstein, B., Martin, S., Giri, P., Scholl, S., Topp, M.S., Jung, W., Vucinic, V., Beck, H.J., Kerkhoff, A., Unger, B., Rank, A., Schroers, R., zum Büschenfelde, C.M., de Wit, M., Trautmann-Grill, K., Kamper, P., Molin, D., Kreissl, S., Kaul, H., von Tresckow, B., Borchmann, S., Behringer, K., Fuchs, M., Rosenwald, A., Klapper, W., Eich, H.T., Baues, C., Zomas, A., Hallek, M., Dietlein, M., Kobe, C. and Diehl, V.
Lancet 404 (10450): 341-352. 27 July 2024

Open-ST: high-resolution spatial transcriptomics in 3D.
Schott, M., León-Periñán, D., Splendiani, E., Strenger, L., Licha, J.R., Pentimalli, T.M., Schallenberg, S., Alles, J., Samut Tagliaferro, S., Boltengagen, A., Ehrig, S., Abbiati, S., Dommerich, S., Pagani, M., Ferretti, E., Macino, G., Karaiskos, N. and Rajewsky, N.
Cell 187 (15): 3953-3972.e26. 25 July 2024

iSuRe-HadCre is an essential tool for effective conditional genetics.
Garcia-Gonzalez, I., Rocha, S.F., Hamidi, A., Garcia-Ortega, L., Regano, A., Sanchez-Muñoz, M.S., Lytvyn, M., Garcia-Cabero, A., Roig-Soucase, S., Schoofs, H., Castro, M., Sabata, H., Potente, M., Graupera, M., Makinen, T. and Benedito, R.
Nucleic Acids Research 52 (13): e56. 22 July 2024

Exploring mechanisms of lipid nanoparticle-mucus interactions in healthy and cystic fibrosis conditions.
Tafech, B., Rokhforouz, M.R., Leung, J., Sung, M.M., Lin, P.J., Sin, D.D., Lauster, D., Block, S., Quon, B.S., Tam, Y., Cullis, P., Feng, J.J. and Hedtrich, S.
Advanced Healthcare Materials 13 (18): e2304525. 17 July 2024

Intergenic risk variant rs56258221 skews the fate of naive CD4(+) T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.
Poch, T., Bahn, J., Casar, C., Krause, J., Evangelakos, I., Gilladi, H., Kunzmann, L.K., Laschtowitz, A., Iuso, N., Schäfer, A.M., Liebig, L.A., Steinmann, S., Sebode, M., Folseraas, T., Engesæter, L.K., Karlsen, T.H., Franke, A., Hubner, N., Schlein, C., Galun, E., Huber, S., Lohse, A.W., Gagliani, N., Schwinge, D. and Schramm, C.
Cell Reports Medicine 5 (7): 101620. 16 July 2024

Discovery of antimicrobial peptides in the global microbiome with machine learning.
Santos-Júnior, C.D., Torres, M.D.T., Duan, Y., Rodríguez Del Río, Á., Schmidt, T.S.B., Chong, H., Fullam, A., Kuhn, M., Zhu, C., Houseman, A., Somborski, J., Vines, A., Zhao, X.M., Bork, P., Huerta-Cepas, J., de la Fuente-Nunez, C. and Coelho, L.P.
Cell 187 (14): 3761-3778. 11 July 2024

Liam tackles complex multimodal single-cell data integration challenges.
Rautenstrauch, P. and Ohler, U.
Nucleic Acids Research 52 (12): e52. 8 July 2024

REEV: review, evaluate and explain variants.
Hramyka, D., Sczakiel, H.L., Zhao, M.X., Stolpe, O., Nieminen, M., Adam, R., Danyel, M., Einicke, L., Hägerling, R., Knaus, A., Mundlos, S., Schwartzmann, S., Seelow, D., Ehmke, N., Mensah, M.A., Boschann, F., Beule, D. and Holtgrewe, M.
Nucleic Acids Research 52 (W1): W148-W158. 5 July 2024

Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo.
Bolesani, E., Bornhorst, D., Iyer, L.I., Zawada, D., Friese, N., Morgan, M., Lange, L., Gonzalez, D., Schrode, N., Leffler, A., Wunder, J., Franke, A., Drakhlis, L., Sebra, R., Schambach, A., Goedel, A., Dubois, N., Dobreva, G., Moretti, A., Zelarayán, L.C., Abdelilah-Seyfried, S. and Zweigerdt, R.
Cardiovascular Research 120 (11): 1295-1311. July 2024

Microproteins encoded by noncanonical ORFs are a major source of tumor-specific antigens in a liver cancer patient meta-cohort.
Camarena, M.E., Theunissen, P., Ruiz, M., Ruiz-Orera, J., Calvo-Serra, B., Castelo, R., Castro, C., Sarobe, P., Fortes, P., Perera-Bel, J. and Albà, M.M.
Science Advances 10 (28): eadn3628. July 2024

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.
Wietek, J., Nozownik, A., Pulin, M., Saraf-Sinik, I., Matosevich, N., Gowrishankar, R., Gat, A., Malan, D., Brown, B.J., Dine, J., Imambocus, B.N., Levy, R., Sauter, K., Litvin, A., Regev, N., Subramaniam, S., Abrera, K., Summarli, D., Goren, E.M., Mizrachi, G., Bitton, E., Benjamin, A., Copits, B.A., Sasse, P., Rost, B.R., Schmitz, D., Bruchas, M.R., Soba, P., Oren-Suissa, M., Nir, Y., Wiegert, J.S. and Yizhar, O.
Nature Methods 21 (7): 1275-1287. July 2024

Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps.
Wu, J., Jones, N., Chao, P.H., Chan, V., Hohenwarter, L., Wu, A., Bergamo, M., Rodríguez-Rodríguez, C., Saatchi, K., Liang, A., Häfeli, U.O., Tan, Z., Hedtrich, S., Andrew, L.J. and Li, S.D.
Biomaterials 308 : 122567. July 2024

Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E., Landthaler, M., Jung, K. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 35 (7): 838-853. July 2024

Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A., Plewka, J., Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A.N., Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova, Y., Minia, I., Mak, P., Landthaler, M., Nowotny, M., Dubin, G., Sattler, M., Suder, P., Popowicz, G.M., Pyrć, K. and Czarna, A.
Nucleic Acids Research 52 (11): 6441-6458. 24 June 2024

CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15 : 1383136. 24 June 2024

Genetic identification of medullary neurons underlying congenital hypoventilation.
Cui, K., Xia, Y., Patnaik, A., Salivara, A., Lowenstein, E.D., Isik, E.G., Knorz, A.L., Airaghi, L., Crotti, M., Garratt, A.N., Meng, F., Schmitz, D., Studer, M., Rijli, F.M., Nothwang, H.G., Rost, B.R., Strauß, U. and Hernandez-Miranda, L.R.
Science Advances 10 (25): eadj0720. 21 June 2024

Natural proteome diversity links aneuploidy tolerance to protein turnover.
Muenzner, J., Trébulle, P., Agostini, F., Zauber, H., Messner, C.B., Steger, M., Kilian, C., Lau, K., Barthel, N., Lehmann, A., Textoris-Taube, K., Caudal, E., Egger, A.S., Amari, F., De Chiara, M., Demichev, V., Gossmann, T.I., Mülleder, M., Liti, G., Schacherer, J., Selbach, M., Berman, J. and Ralser, M.
Nature 630 (8015): 149-157. 6 June 2024

Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer.
Arends, C.M., Kopp, K., Hablesreiter, R., Estrada, N., Christen, F., Moll, U.M., Zeillinger, R., Schmitt, W.D., Sehouli, J., Kulbe, H., Fleischmann, M., Ray-Coquard, I., Zeimet, A., Raspagliesi, F., Zamagni, C., Vergote, I., Lorusso, D., Concin, N., Bullinger, L., Braicu, E.I. and Damm, F.
Leukemia 38 (6): 1378-1389. June 2024

Extraembryonic gut endoderm cells undergo programmed cell death during development.
Batki, J., Hetzel, S., Schifferl, D., Bolondi, A., Walther, M., Wittler, L., Grosswendt, S., Herrmann, B.G. and Meissner, A.
Nature Cell Biology 26 (6): 868-877. June 2024

Systematic benchmarking of single-cell ATAC-sequencing protocols.
De Rop, F.V., Hulselmans, G., Flerin, C., Soler-Vila, P., Rafels, A., Christiaens, V., González-Blas, C.B., Marchese, D., Caratù, G., Poovathingal, S., Rozenblatt-Rosen, O., Slyper, M., Luo, W., Muus, C., Duarte, F., Shrestha, R., Bagdatli, S.T., Corces, M.R., Mamanova, L., Knights, A., Meyer, K.B., Mulqueen, R., Taherinasab, A., Maschmeyer, P., Pezoldt, J., Lambert, C.L.G., Iglesias, M., Najle, S.R., Dossani, Z.Y., Martelotto, L.G., Burkett, Z., Lebofsky, R., Martin-Subero, J.I., Pillai, S., Sebé-Pedrós, A., Deplancke, B., Teichmann, S.A., Ludwig, L.S., Braun, T.P., Adey, A.C., Greenleaf, W.J., Buenrostro, J.D., Regev, A., Aerts, S. and Heyn, H.
Nature Biotechnology 42 (6): 916-926. June 2024

Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.
Grimes, K., Jeong, H., Amoah, A., Xu, N., Niemann, J., Raeder, B., Hasenfeld, P., Stober, C., Rausch, T., Benito, E., Jann, J.C., Nowak, D., Emini, R., Hoenicka, M., Liebold, A., Ho, A., Shuai, S., Geiger, H., Sanders, A.D. and Korbel, J.O.
Nature Genetics 56 (6): 1134-1146. June 2024

Unlocking the secrets of structural variants in a healthy tissue.
Korbel, J.O. and Sanders, A.D.
Nature Genetics 56 (6): 1047-1048. June 2024

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I.V., Oelen, R., Groot, H.E., Benjamins, J.W., Brambs, S., Kaiser, R., Gottschlich, A., Hoffmann, G.V., Eivers, L., Martinez-Navarro, A., Bruns, N., Stiller, S., Akgöl, S., Yue, K., Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O., Kobold, S., Petzold, T., Zimmer, R., Enard, W., Saar, K., Mertins, P., Huebner, N., van der Harst, P., Franke, L.H., van der Wijst, M.G.P., Massberg, S., Heinig, M., Nicolai, L. and Stark, K.
Nature Medicine 30 (6): 1696-1710. June 2024

JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression.
Redmer, T., Raigel, M., Sternberg, C., Ziegler, R., Probst, C., Lindner, D., Aufinger, A., Limberger, T., Trachtova, K., Kodajova, P., Högler, S., Schlederer, M., Stoiber, S., Oberhuber, M., Bolis, M., Neubauer, H.A., Miranda, S., Tomberger, M., Harbusch, N.S., Garces de Los Fayos Alonso, I., Sternberg, F., Moriggl, R., Theurillat, J.P., Tichy, B., Bystry, V., Persson, J.L., Mathas, S., Aberger, F., Strobl, B., Pospisilova, S., Merkel, O., Egger, G., Lagger, S. and Kenner, L.
Molecular Cancer 23 (1): 114. 29 May 2024

Basal delamination during mouse gastrulation primes pluripotent cells for differentiation.
Sato, N., Rosa, V.S., Makhlouf, A., Kretzmer, H., Sampath Kumar, A., Grosswendt, S., Mattei, A.L., Courbot, O., Wolf, S., Boulanger, J., Langevin, F., Wiacek, M., Karpinski, D., Elosegui-Artola, A., Meissner, A., Zernicka-Goetz, M. and Shahbazi, M.N.
Developmental Cell 59 (10): 1252-1268. 20 May 2024

Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells.
Chiariello, A.M., Abraham, Alex, Bianco, S., Esposito, A., Fontana, A., Vercellone, F., Conte, M. and Nicodemi, M.
Nature Communications 15 (1): 4014. 13 May 2024

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.
Hurtado, A., Mota-Gómez, I., Lao, M., Real, F.M., Jedamzick, J., Burgos, M., Lupiáñez, D.G., Jiménez, R. and Barrionuevo, F.J.
Nature Communications 15 (1): 3809. 7 May 2024

Next questions in autophagy.
Cuervo, A.M., Elazar, Z., Evans, C., Ge, L., Hansen, M., Jäättelä, M., Liang, J.R.A., Loos, B., Mizushima, N., Simon, A.K., Tooze, S., Yoshimori, T. and Nakamura, S.
Nature Cell Biology 26 (5): 661-666. May 2024

Neighborhood-level inequalities and influencing factors of COVID-19 incidence in berlin based on Bayesian spatial modelling.
Zhuang, S., Wolf, K., Schmitz, T., Roth, A., Sun, Y., Savaskan, N. and Lakes, T.
Sustainable Cities and Society 104 : 105301. May 2024

Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish.
Cardeira-da-Silva, J., Wang, Q., Sagvekar, P., Mintcheva, J., Latting, S., Günther, S., Ramadass, R., Yekelchyk, M., Preussner, J., Looso, M., Junker, J.P. and Stainier, D.Y.R.
Nature Communications 15 (1): 3637. 29 April 2024

Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit.
Peng, Y., Bjelde, A., Aceituno, P.V., Mittermaier, F.X., Planert, H., Grosser, S., Onken, J., Faust, K., Kalbhenn, T., Simon, M., Radbruch, H., Fidzinski, P., Schmitz, D., Alle, H., Holtkamp, M., Vida, I., Grewe, B.F. and Geiger, J.R.P.
Science 384 (6693): 338-343. 26 April 2024

Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D., Knapstein, P.R., Otto, E., Köhli, P., Sevecke, J., Graef, F., Graffmann, C., Fuchs, M., Jiang, S., Rickert, M., Erdmann, C., Appelt, J., Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G., Xie, W., Donat, A., Schinke, T., Ivanov, A., Tchouto, M.N., Beule, D., Frosch, K.H., Baranowsky, A., Tsitsilonis, S. and Keller, J.
Science Translational Medicine 16 (743): eadk9129. 17 April 2024

Water conservation overrides osmotic diuresis during SGLT2 inhibition in patients with heart failure.
Marton, A., Saffari, S.E., Rauh, M., Sun, R.N., Nagel, A.M., Linz, P., Lim, T.T., Takase-Minegishi, K., Pajarillaga, A., Saw, S., Morisawa, N., Yam, W.K., Minegishi, S., Totman, J.J., Teo, S., Teo, L.L.Y., Ng, C.T., Kitada, K., Wild, J., Kovalik, J.P., Luft, F.C., Greasley, P.J., Chin, C.W.L., Sim, D.K.L. and Titze, J.
Journal of the American College of Cardiology 83 (15): 1386-1398. 16 April 2024

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
Tiniakou, I., Hsu, P.F., Lopez-Zepeda, L.S., Garipler, G., Esteva, E., Adams, N.M., Jang, G., Soni, C., Lau, C.M., Liu, F., Khodadadi-Jamayran, A., Rodrick, T.C., Jones, D., Tsirigos, A., Ohler, U., Bedford, M.T., Nimer, S.D., Kaartinen, V., Mazzoni, E.O. and Reizis, B.
Science Immunology 9 (94): eadi1023. 12 April 2024

Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Ihlow, J., Penter, L., Vuong, L.G., Bischoff, P., Obermayer, B., Trinks, A., Blau, O., Behnke, A., Conrad, T., Morkel, M., Wu, C.J., Westermann, J., Bullinger, L., von Brünneck, A.C., Blüthgen, N., Horst, D. and Praktiknjo, S.D.
Med 6 (4): 100548. 11 April 2024

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15 (1): 3146. 11 April 2024

Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk.
de Biase, M.S., Massip, F., Wei, T.T., Giorgi, F.M., Stark, R., Stone, A., Gladwell, A., O'Reilly, M., Schütte, D., de Santiago, I., Meyer, K.B., Markowetz, F., Ponder, B.A.J., Rintoul, R.C. and Schwarz, R.F.
Genome Medicine 16 (1): 54. 8 April 2024

ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C., Thery, F., Wirth, E.K., Ochs, S., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A.
Cardiovascular Research 120 (6): 644-657. 6 April 2024

Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143 (14): 1365-1378. 4 April 2024

Cell states in cancer: drivers, passengers, and trailers.
Gargiulo, G., Serresi, M. and Marine, J.C.
Cancer Discovery 14 (4): 610-614. 4 April 2024

Efficient recovery of complete gut viral genomes by combined short- and long-read sequencing.
Chen, J., Sun, C., Dong, Y., Jin, M., Lai, S., Jia, L., Zhao, X., Wang, H., Gao, N.L., Bork, P., Liu, Z., Chen, W.H. and Zhao, X.M.
Advanced Science 11 (13): 2305818. 3 April 2024

External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction.
Mehl, J., Farahani, S.K., Brauer, E., Klaus-Bergmann, A., Thiele, T., Ellinghaus, A., Bartels-Klein, E., Koch, K., Schmidt-Bleek, K., Petersen, A., Gerhardt, H., Vogel, V. and Duda, G.N.
Advanced Science 11 (13): e2307050. 3 April 2024

The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
Zaupa, M., Nagaraj, N., Sylenko, A., Baier, H., Sawamiphak, S. and Filosa, A.
Neuron 112 (7): 1150-1164. 3 April 2024

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on pulmonary circulation & right ventricular function.
Ameri, P., Mercurio, V., Pollesello, P., Anker, M.S., Backs, Jo., Bayes-Genis, A., Borlaug, B.A., Burkhoff, D., Caravita, S., Chan, S.Y., de Man, F., Giannakoulas, G., González, A., Guazzi, M., Hassoun, P.M., Hemnes, A.R., Maack, C., Madden, B., Melenovsky, V., Müller, O.J., Papp, Z., Pullamsetti, S.S., Rainer, P.P., Redfield, M.M., Rich, S., Schiattarella, G.G., Skaara, H., Stellos, K., Tedford, R.J., Thum, T., Vachiery, J.L., van der Meer, P., Van Linthout, S., Pruszczyk, P., Seferovic, P., Coats, A.J.S., Metra, M., Rosano, G., Rosenkranz, S. and Tocchetti, C.G.
European Journal of Heart Failure 26 (4): 707-729. April 2024

Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.
Fislage, M., Winzeck, S., Woodrow, R., Lammers-Lietz, F., Stamatakis, E.A., Correia, M.M., Preller, J., Feinkohl, I., Hendrikse, J., Pischon, T., Spies, C.D., Slooter, A.J.C., Winterer, G., Menon, D.K. and Zacharias, N.
Alzheimer's and Dementia 20 (4): 2861-2872. April 2024

Pangenome graph construction from genome alignments with Minigraph-Cactus.
Hickey, G., Monlong, J., Ebler, J., Novak, A.M., Eizenga, J.M., Gao, Y., Marschall, T., Li, H. and Paten, B.
Nature Biotechnology 42 (4): 663-673. April 2024

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15 (1): 2611. 23 March 2024

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner, D., Sieverding, K., Srinidhi, J., Zellner, S., Secker, C., Yilmaz, R., Dyckow, J., Amr, S., Ponomarenko, A., Tunaboylu, E., Douahem, Y., Schlag, J.S., Rodríguez Martínez, L., Kislinger, G., Niemann, C., Nalbach, K., Ruf, W.P., Uhl, J., Hollenbeck, J., Schirmer, L., Catanese, A., Lobsiger, C.S., Danzer, K.M., Yilmazer-Hanke, D., Münch, C., Koch, P., Freischmidt, A., Fetting, M., Behrends, C., Parlato, R. and Weishaupt, J.H.
Journal of Experimental Medicine 221 (5): e20221190. 22 March 2024

Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10 (12): eadl1710. 22 March 2024

Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022.
Baumgartner, F., Baer, C., Bamopoulos, S.A., Ayoub, E., Truger, M., Meggendorfer, M., Lenk, M., Hoermann, G., Hutter, S., Müller, H., Walter, W., Mueller, M.L., Nadarajah, Ni., Blombery, P., Keller, U., Kern, W., Haferlach, C. and Haferlach, T.
Blood 143 (12): 1139-1156. 21 March 2024

Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Müller-Calleja, N., Grunz, K., Nguyen, T.S., Posma, J., Pedrosa, D., Meineck, M., Hollerbach, A., Braun, J., Muth, S., Schild, H., Saar, K., Hübner, N., Krishnaswamy, S., Royce, J., Teyton, L., Lemmermann, N.A., Weinmann-Menke, J., Lackner, K.J. and Ruf, W.
Blood 143 (12): 1167-1180. 21 March 2024

Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho, I.L., Li, C.Y., Wang, F., Zhao, L., Liu, J., Yen, E.Y., Dyke, C.A., Shah, R., Liu, Z., Çetin, A.O., Chu, Y., Citron, F., Attanasio, S., Corti, D., Darbaniyan, F., Del Poggetto, E., Loponte, S., Liu, J., Soeung, M., Chen, Z., Jiang, S., Jiang, H., Inoue, A., Gao, S., Deem, A., Feng, N., Ying, H., Kim, M., Giuliani, V., Genovese, G., Zhang, J., Futreal, A., Maitra, A., Heffernan, T., Wang, L., Do, K.A., Gargiulo, G., Draetta, G., Carugo, A., Lin, R. and Viale, A.
Science Advances 10 (11): eadd9342. 15 March 2024

CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83 (4): 499-507. 12 March 2024

Genetic determinants of micronucleus formation in vivo.
Adams, D.J., Barlas, B., McIntyre, R.E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J.R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N.A., Harle, V., Olvera-León, R., Robles-Espinoza, C.D., Speak, A.O., Geisler, N., Weninger, W.J., Geyer, S.H., Hewinson, J., Karp, N.A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M.S., Rowland, B.D., Lelliott, C.J., Del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A.G., Rooimans, M.A., de Lange, J., Mohun, T.J., Arends, M.J., Kentistou, K.A., Coelho, P.A., Zhao, Y., Zecchini, H., Perry, J.R.B., Jackson, S.P. and Balmus, G.
Nature 627 (8002): 130-136. 7 March 2024

Canonical and non-canonical integrin-based adhesions dynamically interconvert.
Lukas, F., Matthaeus, C., López-Hernández, T., Lahmann, I., Schultz, N., Lehmann, M., Puchkov, D., Pielage, J., Haucke, V. and Maritzen, T.
Nature Communications 15 (1): 2093. 7 March 2024

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14 (3): 492-507. 1 March 2024

Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383 (6686): 992-998. 1 March 2024

Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced stage Hodgkin Lymphoma: results from the randomized international GHSG HD18 trial.
Ferdinandus, J., Müller, H., Damaschin, C., Jacob, A.S., Meissner, J., Krasniqi, F., Mey, U., Schöndube, D., Thiemer, J., Mathas, S., Zijlstra, J., Greil, R., Feuring-Buske, M., Markova, J., Rüffer, J.U., Kobe, C., Eich, H.T., Baues, C., Fuchs, M., Borchmann, P. and Behringer, K.
Annals of Oncology 35 (3): 276-284. March 2024

Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories.
Gross, C.C., Schulte-Mecklenbeck, A., Steinberg, O.V., Wirth, T., Lauks, S., Bittner, S., Schindler, P., Baranzini, S.E., Groppa, S., Bellmann-Strobl, J., Bünger, N., Chien, C., Dawin, E., Eveslage, M., Fleischer, V., Gonzalez-Escamilla, G., Gisevius, B., Haas, J., Kerschensteiner, M., Kirstein, L., Korsukewitz, C., Lohmann, L., Lünemann, J.D., Luessi, F., Meyer Zu Hörste, G., Motte, J., Ruck, T., Ruprecht, K., Schwab, N., Steffen, F., Meuth, S.G., Paul, F., Wildemann, B., Kümpfel, T., Gold, R., Hahn, T., Zipp, F., Klotz, L. and Wiendl, H.
Science Translational Medicine 16 (740): eade8560. March 2024

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.
Müller, P., de la Cuesta-Zuluaga, J., Kuhn, M., Baghai Arassi, M., Treis, T., Blasche, S., Zimmermann, M., Bork, P., Patil, K.R., Typas, A., Garcia-Santamarina, S. and Maier, L.
Nature Protocols 19 (3): 668-699. March 2024

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J., Meinhardt, J., Aschman, T., Chua, R.L., Farztdinov, V., Lukassen, S., Ten, F.W., Friebel, E., Ishaque, N., Franz, J., Huhle, V.H., Mothes, R., Peters, K., Thomas, C., Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D., Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S., Horst, D., Kurth, F., Müller, M.A., Gassen, N.C., Melchert, J., Jechow, K., Timmermann, B., Fernandez-Zapata, C., Böttcher, C., Stenzel, W., Krüger, E., Landthaler, M., Wyler, E., Corman, V., Stadelmann, C., Ralser, M., Eils, R., Heppner, F.L., Mülleder, M., Conrad, C. and Radbruch, H.
Nature Neuroscience 27 (3): 409-420. March 2024

High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial.
Schorb, E., Isbell, L.K., Kerkhoff, A., Mathas, S., Braulke, F., Egerer, G., Röth, A., Schliffke, S., Borchmann, P., Brunnberg, U., Kroschinsky, F., Möhle, R., Rank, A., Wellnitz, D., Kasenda, B., Pospiech, L., Wendler, J., Scherer, F., Deckert, M., Henkes, E., von Gottberg, P., Gmehlin, D., Backenstraß, M., Jensch, A., Burger-Martin, E., Grishina, O., Fricker, H., Malenica, N., Orbán, A., Duyster, J., Ihorst, G., Finke, J. and Illerhaus, G.
Lancet Haematology 11 (3): e196-e205. March 2024

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Flügel, T., Schacherl, M., Unbehaun, A., Schroeer, B., Dabrowski, M., Bürger, J., Mielke, T., Sprink, T., Diebolder, C.A., Guillén Schlippe, Y.V. and Spahn, C.M.T.
Nature Communications 15 (1): 1756. 26 February 2024

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.
Mertens, T.F., Liebheit, A.T., Ehl, J., Köhler, R., Rakhymzhan, A., Woehler, A., Katthän, L., Ebel, G., Liublin, W., Kasapi, A., Triantafyllopoulou, A., Schulz, T.J., Niesner, R.A. and Hauser, A.E.
Nature Communications 15 (1): 1764. 26 February 2024

The cycling and aging mouse female reproductive tract at single-cell resolution.
Winkler, I., Tolkachov, A., Lammers, F., Lacour, P., Daugelaite, K., Schneider, N., Koch, M.L., Panten, J., Grünschläger, F., Poth, T., Ávila, B.M.d., Schneider, A., Haas, S., Odom, D.T. and Gonçalves, Â.
Cell 187 (4): 981-998. 15 February 2024

Metrics reloaded: recommendations for image analysis validation.
Maier-Hein, L., Reinke, A., Godau, P., Tizabi, M.D., Buettner, F., Christodoulou, E., Glocker, B., Isensee, F., Kleesiek, J., Kozubek, M., Reyes, M., Riegler, M.A., Wiesenfarth, M., Kavur, A.E., Sudre, C.H., Baumgartner, M., Eisenmann, M., Heckmann-Nötzel, D., Rädsch, T., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Blaschko, M.B., Cardoso, M.J., Cheplygina, V., Cimini, B.A., Collins, G.S., Farahani, K., Ferrer, L., Galdran, A., van Ginneken, B., Haase, R., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Karthikesalingam, A., Kofler, F., Kopp-Schneider, A., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G., Madani, A., Maier-Hein, K., Martel, A.L., Mattson, P., Meijering, E., Menze, B., Moons, K.G.M., Müller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rajpoot, N., Rieke, N., Saez-Rodriguez, J., Sánchez, C.I., Shetty, S., van Smeden, M., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Van Calster, B., Varoquaux, G. and Jäger, P.F.
Nature Methods 21 (2): 195-212. 12 February 2024

Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P.L., Schmidt, V., Madsen, L.S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M.N., Romero-Ramos, M., Holm, C.K., Andersen, G.R., Zhao, H., Schuck, P., Nygaard, J.V., Sutherland, D.S., Eskildsen, S.F., Willnow, T.E., Brooks, D.J. and Vorup-Jensen, T.
Nature Communications 15 (1): 1224. 9 February 2024

Functional and evolutionary significance of unknown genes from uncultivated taxa.
Rodríguez Del Río, Á., Giner-Lamia, J., Cantalapiedra, C.P., Botas, J., Deng, Z., Hernández-Plaza, A., Munar-Palmer, M., Santamaría-Hernando, S., Rodríguez-Herva, J.J., Ruscheweyh, H.J., Paoli, L., Schmidt, T.S.B., Sunagawa, S., Bork, P., López-Solanilla, E., Coelho, L.P. and Huerta-Cepas, J.
Nature 626 (7998): 377-384. 8 February 2024

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15 (1): 898. 6 February 2024

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
Company, C., Schmitt, M.J., Dramaretska, Y., Serresi, M., Kertalli, S., Jiang, B., Yin, J.A., Aguzzi, A., Barozzi, I. and Gargiulo, G.
Nature Communications 15 (1): 897. 5 February 2024

Gamma oscillation plasticity is mediated via parvalbumin interneurons.
Hadler, M.D., Tzilivaki, A., Schmitz, D., Alle, H. and Geiger, J.R.P.
Science Advances 10 (5): eadj7427. 2 February 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024

Genetic characterization of primary mediastinal B-cell lymphoma: pathogenesis and patient outcomes.
Noerenberg, D., Briest, F., Hennch, C., Yoshida, K., Hablesreiter, R., Takeuchi, Y., Ueno, H., Staiger, A.M., Ziepert, M., Asmar, F., Locher, B.N., Toth, E., Weber, T., Amini, R.M., Klapper, W., Bouzani, M., Poeschel, V., Rosenwald, A., Held, G., Campo, E., Ishaque, N., Stamatopoulos, K., Kanellis, G., Anagnostopoulos, I., Bullinger, L., Goldschmidt, N., Zinzani, P.L., Bödör, C., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Journal of Clinical Oncology 42 (4): 452-466. 1 February 2024

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M., Serve, S., Marx, A.F., Fadejeva, J., Saikali, P., Dzamukova, M., Durán-Hernández, N., Kommer, C., Heinrich, F., Durek, P., Heinz, G.A., Höfer, T., Mashreghi, M.F., Kühn, R., Pinschewer, D.D. and Löhning, M.
Nature Immunology 25 (2): 256-267. February 2024

CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting.
Graham, S., Vu, Q.D., Jahanifar, M., Weigert, M., Schmidt, U., Zhang, W., Zhang, J., Yang, S., Xiang, J., Wang, X., Rumberger, J.L., Baumann, E., Hirsch, P., Liu, L., Hong, C., Aviles-Rivero, A.I., Jain, A., Ahn, H., Hong, Y., Azzuni, H., Xu, M., Yaqub, M., Blache, M.C., Piégu, B., Vernay, B., Scherr, T., Böhland, M., Löffler, K., Li, J., Ying, W., Wang, C., Snead, D., Raza, S.E.A., Minhas, F. and Rajpoot, N.M.
Medical Image Analysis 92 : 103047. February 2024

The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma.
Pan, X., AbdulJabbar, K., Coelho-Lima, J., Grapa, A.I., Zhang, H., Cheung, A.H.K., Baena, J., Karasaki, T., Wilson, C.R., Sereno, M., Veeriah, S., Aitken, S.J., Hackshaw, A., Nicholson, A.G., Jamal-Hanjani, M., Swanton, C., Yuan, Y., Le Quesne, J. and Moore, D.A.
Nature Cancer 5 (2): 347-363. February 2024

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y., Leney-Greene, M., Lynberg, M., Gabrielski, J.Q., Xu, X., Schwarz, B., Zheng, L., Balasubramaniyam, A., Ham, H., Chao, B., Zhang, Y., Matthews, H.F., Cui, J., Yao, Y., Kubo, S., Chanchu, J.M., Morawski, A.R., Cook, S.A., Jiang, P., Ravell, J.C., Cheng, Y.H., George, A., Faruqi, A., Pagalilauan, A.M., Bergerson, J.R.E., Ganesan, S., Chauvin, S.D., Aluri, J., Edwards-Hicks, J., Bohrnsen, E., Tippett, C., Omar, H., Xu, L., Butcher, G.W., Pascall, J., Karakoc-Aydiner, E., Kiykim, A., Maecker, H., Tezcan, İ., Esenboga, S., Heredia, R.J., Akata, D., Tekin, S., Kara, A., Kuloglu, Z., Unal, E., Kendirli, T., Dogu, F., Karabiber, E., Atkinson, T.P., Cochet, C., Filhol, O., Bosio, C.M., Davis, M.M., Lifton, R.P., Pearce, E.L., Daumke, O., Aytekin, C., Şahin, G.E., Aksu, A.Ü., Uzel, G., Koneti Rao, V., Sari, S., Boztug, K., Cagdas, D., Haskologlu, S., Ikinciogullari, A., Schwefel, D., Vilarinho, S., Baris, S., Ozen, A., Su, H.C. and Lenardo, M.J.
Nature Immunology 25 (2): 282-293. February 2024

Understanding metric-related pitfalls in image analysis validation.
Reinke, A., Tizabi, M.D., Baumgartner, M., Eisenmann, M., Heckmann-Nötzel, D., Kavur, A.E., Rädsch, T., Sudre, C.H., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Buettner, F., Cardoso, M.J., Cheplygina, V., Chen, J., Christodoulou, E., Cimini, B.A., Farahani, K., Ferrer, L., Galdran, A., van Ginneken, B., Glocker, B., Godau, P., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Isensee, F., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Kleesiek, J., Kofler, F., Kooi, T., Kopp-Schneider, A., Kozubek, M., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G., Madani, A., Maier-Hein, K., Martel, A.L., Meijering, E., Menze, B., Moons, K.G.M., Müller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rafelski, S.M., Rajpoot, N., Reyes, M., Riegler, M.A., Rieke, N., Saez-Rodriguez, J., Sánchez, C.I., Shetty, S., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Van Calster, B., Varoquaux, G., Yaniv, Z.R., Jäger, P.F. and Maier-Hein, L.
Nature Methods 21 (2): 182-194. February 2024

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Hofman, D.A., Ruiz-Orera, J., Yannuzzi, I., Murugesan, R., Brown, A., Clauser, K.R., Condurat, A.L., van Dinter, J.T., Engels, S.A.G., Goodale, A., van der Lugt, J., Abid, T., Wang, L., Zhou, K.N., Vogelzang, J., Ligon, K.L., Phoenix, T.N., Roth, J.A., Root, D.E, Hubner, N., Golub, T.R., Bandopadhayay, P., van Heesch, S. and Prensner, J.R.
Molecular Cell 84 (2): 261-276. 18 January 2024

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
Uehata, T., Yamada, S., Ori, D., Vandenbon, A., Giladi, A., Jelinski, A., Murakawa, Y., Watanabe, H., Takeuchi, K., Toratani, K., Mino, T., Kiryu, H., Standley, D.M., Tsujimura, T., Ikawa, T., Kondoh, G., Landthaler, M., Kawamoto, H., Rodewald, H.R., Amit, I., Yamamoto, R., Miyazaki, M. and Takeuchi, O.
Blood 143 (3): 243-257. 18 January 2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z., Zhang, S., Dupont, M., Ragaller, F., Sjule, E., Cabezas-Caballero, J., Deimel, L.P., Robertson, H., Russell, R.A., Dushek, O., Sezgin, E., Karaji, N. and Sattentau, Q.J.
Nature Communications 15 (1): 541. 15 January 2024

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske, Y., Cappel, C., Cremer, N., Hoffmann, P., Koudelka, T., Tholey, A., Heinemann, U., Daumke, O. and Damme, M.
Nucleic Acids Research 52 (1): 370-384. 11 January 2024

Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler, F., Ostertag, M.S., Sommermann, T., Weidl, D., Sterz, K.R., Kutz, H., Moosmann, A., Feller, S.M., Geerlof, A., Biesinger, B., Popowicz, G.M., Kirchmair, J. and Kieser, A.
Nature Communications 15 (1): 414. 10 January 2024

High-sensitivity cardiac troponin I enhances preeclampsia prediction beyond maternal factors and the sFlt-1/PlGF ratio.
Bacmeister, L., Goßling, A., Buellesbach, A., Birukov, A., Myers, J.E., Thomas, S.T., Lee, S., Andersen, M.S., Jorgensen, J.S., Diemert, A., Blois, S.M., Arck, P.C., Hecher, K., Herse, F., Blankenberg, S., Dechend, R., Westermann, D. and Zeller, T.
Circulation 149 (2): 95-106. 9 January 2024

SPIRE: a Searchable, Planetary-scale mIcrobiome REsource.
Schmidt, T.S.B., Fullam, A., Ferretti, P., Orakov, A., Maistrenko, O.M., Ruscheweyh, H.J., Letunic, I., Duan, Y., Van Rossum, T., Sunagawa, S., Mende, D.R., Finn, R.D., Kuhn, M., Pedro Coelho, L. and Bork, P.
Nucleic Acids Research 52 (D1): D777-D783. 5 January 2024

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.
Borsa, M., Obba, S., Richter, F.C., Zhang, H., Riffelmacher, T., Carrelha, J., Alsaleh, G., Jacobsen, S.E.W. and Simon, A.K.
Autophagy 20 (1): 45-57. January 2024

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.
Bruedigam, C., Porter, A.H., Song, A., Vroeg In de Wei, G., Stoll, T., Straube, J., Cooper, L., Cheng, G., Kahl, V.F.S., Sobinoff, A.P., Ling, V.Y., Jebaraj, B.M.C., Janardhanan, Y., Haldar, R., Bray, L.J., Bullinger, L., Heidel, F.H., Kennedy, G.A., Hill, M.M., Pickett, H.A., Abdel-Wahab, O., Hartel, G. and Lane, S.W.
Nature Cancer 5 (1): 47-65. January 2024

Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease.
Essex, M., Rios Rodriguez, V., Rademacher, J., Proft, F., Löber, U., Marko, L., Pleyer, U., Strowig, T., Marchand, J., Kirwan, J.A., Siegmund, B., Forslund, S.K. and Poddubnyy, D.
Arthritis & Rheumatology 76 (1): 48-58. January 2024

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14 (1): 8043. 19 December 2023

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Wang, Z., Shaabani, S., Gao, X., Ng, Y.L.D., Sapozhnikova, V., Mertins, P., Krönke, J. and Dömling, A.
Nature Communications 14 (1): 8437. 19 December 2023

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk, M.C., Gleixner, J.G., Heigwer, F., Vonficht, D., Valentini, E., Aydin, Z., Tonin, E., Del Prete, S., Mahara, S., Throm, Y., Hetzer, J., Heide, D., Stegle, O., Odom, D.T., Feldmann, A., Haas, S., Heikenwalder, M. and Boutros, M.
Developmental Cell 58 (24): 2914-2929. 18 December 2023

Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
Smolgovsky, S., Bayer, A.L., Kaur, K., Sanders, E., Aronovitz, M., Filipp, M.E., Thorp, E.B., Schiattarella, G.G., Hill, J.A., Blanton, R.M., Cubillos-Ruiz, J.R. and Alcaide, P.
Journal of Clinical Investigation 133 (24): e171874. 15 December 2023

Autoantibodies against the chemokine receptor 3 predict cardiovascular risk.
Müller, F.S., Aherrahrou, Z., Grasshoff, H., Heidorn, M.W., Humrich, J.Y., Johanson, L., Aherrahrou, R., Reinberger, T., Schulz, A., Ten Cate, V., Robles, A.P., Koeck, T., Rapp, S., Lange, T., Brachaczek, L., Luebber, F., Erdmann, J., Heidecke, H., Schulze-Forster, K., Dechend, R., Lackner, K.J., Pfeiffer, N., Ghaemi Kerahrodi, J., Tüscher, O., Schwarting, A., Strauch, K., Münzel, T., Prochaska, J.H., Riemekasten, G. and Wild, P.S.
European Heart Journal 44 (47): 4935-4949. 14 December 2023

RIF1 regulates early replication timing in murine B cells.
Malzl, D., Peycheva, M., Rahjouei, A., Gnan, S., Klein, K.N., Nazarova, M., Schoeberl, U.E., Gilbert, D.M., Buonomo, S.C.B., Di Virgilio, M., Neumann, T. and Pavri, R.
Nature Communications 14 (1): 8049. 11 December 2023

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.
Dönig, J., Mende, H., Davila Gallesio, J., Wagner, K., Hotz, P., Schunck, K., Piller, T., Hölper, S., Uhan, S., Kaulich, M., Wirth, M., Keller, U., Tascher, G., Bohnsack, K.E. and Müller, S.
Nature Communications 14 (1): 8121. 8 December 2023

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.
Ilia, K., Shakiba, N., Bingham, T., Jones, R.D., Kaminski, M.M., Aravera, E., Bruno, S., Palacios, S., Weiss, R., Collins, J.J., Del Vecchio, D. and Schlaeger, T.M.
Science Advances 9 (48): eadg8495. December 2023

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119 (18): 2902-2916. December 2023

Insm1 regulates mTEC development and immune tolerance.
Tao, W., Ye, Z., Wei, Y., Wang, J., Yang, W., Yu, G., Xiong, J. and Jia, S.
Cellular and Molecular Immunology 20 (12): 1472-1486. December 2023

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
Benedum, J., Franke, V., Appel, L.M., Walch, L., Bruno, M., Schneeweiss, R., Gruber, J., Oberndorfer, H., Frank, E., Strobl, X., Polyansky, A., Zagrovic, B., Akalin, A. and Slade, D.
Nature Communications 14 (1): 7912. 30 November 2023

Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages.
Apaydin, O., Altaikyzy, A., Filosa, A. and Sawamiphak, S.
Developmental Cell 58 (22): 2460-2476.e7. 20 November 2023

Latent human herpesvirus 6 is reactivated in CAR T cells.
Lareau, C.A., Yin, Y., Maurer, K., Sandor, K.D., Daniel, B., Yagnik, G., Peña, J., Crawford, J.C., Spanjaart, A.M., Gutierrez, J.C., Haradhvala, N.J., Riberdy, J.M., Abay, T., Stickels, R.R., Verboon, J.M., Liu, V., Buquicchio, F.A., Wang, F., Southard, J., Song, R., Li, W., Shrestha, A., Parida, L., Getz, G., Maus, M.V., Li, S., Moore, A., Roberts, Z.J., Ludwig, L.S., Talleur, A.C., Thomas, P.G., Dehghani, H., Pertel, T., Kundaje, A., Gottschalk, S., Roth, T.L., Kersten, M.J., Wu, C.J., Majzner, R.G. and Satpathy, A.T.
Nature 623 : 608-615. 16 November 2023

IL-33 expression is lower in current smokers at both transcriptomic and protein level.
Faiz, A., Mahbub, R.M., Boedijono, F.S., Tomassen, M.I., Kooistra, W., Timens, W., Nawijn, M., Hansbro, P.M., Johansen, M.D., Pouwels, S.D., Heijink, I.H., Massip, F., de Biase, M.S., Schwarz, R.F., Adcock, I.M., Chung, K.F., van der Does, A., Hiemstra, P.S., Goulaouic, H., Xing, H., Abdulai, R., de Rinaldis, E., Cunoosamy, D., Harel, S., Lederer, D., Nivens, M.C., Wark, P.A., Kerstjens, H.A.M., Hylkema, M.N., Brandsma, C.A. and van den Berge, M.
American Journal of Respiratory and Critical Care Medicine 208 (10): 1075-1087. 15 November 2023

Lipid nanoparticle-mediated hit-and-run approaches yield efficient and safe in situ gene editing in human skin.
Bolsoni, J., Liu, D., Mohabatpour, F., Ebner, R., Sadhnani, G., Tafech, B., Leung, J., Shanta, S., An, K., Morin, T., Chen, Y., Arguello, A., Choate, K., Jan, E., Ross, C.J.D., Brambilla, D., Witzigmann, D., Kulkarni, J., Cullis, P.R. and Hedtrich, S.
ACS Nano 17 (21): 22046-22059. 14 November 2023

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
Chatzinikolaou, G., Stratigi, K., Siametis, A., Goulielmaki, E., Akalestou-Clocher, A., Tsamardinos, I., Topalis, P., Austin, C., Bouwman, B.A.M., Crosetto, N., Altmüller, J. and Garinis, G.A.
Science Advances 9 (45): eadi2095. 10 November 2023

Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
Reincke, S.M., von Wardenburg, N., Homeyer, M.A., Kornau, H.C., Spagni, G., Li, L.Y., Kreye, J., Sánchez-Sendín, E., Blumenau, S., Stappert, D., Radbruch, H., Hauser, A.E., Künkele, A., Edes, I., Schmitz, D. and Prüss, H.
Cell 186 (23): 5084-5097.e18. 9 November 2023

Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14 (1): 6947. 7 November 2023

Leveraging large language models for decision support in personalized oncology.
Benary, M., Wang, X.D., Schmidt, M., Soll, D., Hilfenhaus, G., Nassir, M., Sigler, C., Knödler, M., Keller, U., Beule, D., Keilholz, U., Leser, U. and Rieke, D.T.
JAMA Network Open 6 (11): e2343689. November 2023

Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37 (11): 2237-2249. November 2023

Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients.
Jahn, E., Saadati, M., Fenaux, P., Gobbi, M., Roboz, G.J., Bullinger, L., Lutsik, P., Riedel, A., Plass, C., Jahn, N., Walter, C., Holzmann, K., Hao, Y., Naim, S., Schreck, N., Krzykalla, J., Benner, A., Keer, H.N., Azab, M., Döhner, K. and Döhner, H.
Leukemia 37 (11): 2187-2196. November 2023

Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
Nikopoulou, C., Kleinenkuhnen, N., Parekh, S., Sandoval, T., Ziegenhain, C., Schneider, F., Giavalisco, P., Donahue, K.F., Vesting, A.J., Kirchner, M., Bozukova, M., Vossen, C., Altmüller, J., Wunderlich, T., Sandberg, R., Kondylis, V., Tresch, A. and Tessarz, P.
Nature Aging 3 (11): 1430-1445. November 2023

Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine - a prospective cohort study by the AGMT.
Pleyer, L., Vaisband, M., Drost, M., Pfeilstöcker, M., Stauder, R., Heibl, S., Sill, H., Girschikofsky, M., Stampfl-Mattersberger, M., Pichler, A., Hartmann, B., Petzer, A., Schreder, M., Schmitt, C.A., Vallet, S., Melchardt, T., Zebisch, A., Pichler, P., Zaborsky, N., Machherndl-Spandl, S., Wolf, D., Keil, F., Hasenauer, J., Larcher-Senn, J. and Greil, R.
American Journal of Hematology 98 (11): 1685-1698. November 2023

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li, X., Wu, F., Günther, S., Looso, M., Kuenne, C., Zhang, T., Wiesnet, M., Klatt, S., Zukunft, S., Fleming, I., Poschet, G., Wietelmann, A., Atzberger, A., Potente, M., Yuan, X. and Braun, T.
Nature 622 (7983): 619-626. 19 October 2023

Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14 (1): 6543. 17 October 2023

Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B., Zhang, S., Polovitskaya, M.M., Yi, J., Ye, B., Li, R., Huang, X., Yin, J., Neuens, S., Balfroid, T., Soblet, J., Vens, D., Aeby, A., Li, X., Cai, J., Song, Y., Li, Y., Tartaglia, M., Li, Y., Jentsch, T.J., Yang, M. and Liu, Z.
Science Advances 9 (41): eadg4479. 13 October 2023

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
Nurminen, A., Jaatinen, S., Taavitsainen, S., Högnäs, G., Lesluyes, T., Ansari-Pour, N., Tolonen, T., Haase, K., Koskenalho, A., Kankainen, M., Jasu, J., Rauhala, H., Kesäniemi, J., Nikupaavola, T., Kujala, P., Rinta-Kiikka, I., Riikonen, J., Kaipia, A., Murtola, T., Tammela, T.L., Visakorpi, T., Nykter, M., Wedge, D.C., Van Loo, P. and Bova, G.S.
Genome Medicine 15 (1): 82. 12 October 2023

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S., Lucht, M.T., Petzoldt, A., Kong, S., Sun, J., Vines, J.H., Telugu, N.S., Diecke, S., Kaas, T., Bullmann, T., Schmied, C., Löwe, D., King, J.S., Cho, W., Hallermann, S., Puchkov, D., Sigrist, S.J. and Haucke, V.
Science 382 (6667): 223-230. 12 October 2023

Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E., Planas-Fèlix, M., Burkert, M., Puiggròs, M., Toedling, J., Thiessen, N., Blanc, E., Szymansky, A., Hertwig, F., Ishaque, N., Beule, D., Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F., Haase, K., Schulte, J.H. and Henssen, A.G.
Cell Genomics 3 (10): 100402. 11 October 2023

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M.K., Shringarpure, S.S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B.M., Thomas, L.F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J.V.T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A., Jeong, A., Fawcett, K.A., Baurecht, H., Rodriguez, E., Alves, A.C., Kumar, A., Sleiman, P.M., Chang, X., Medina-Gomez, C., Hu, C., Xu, C.J., Qi, C., El-Heis, S., Titcombe, P., Antoun, E., Fadista, J., Wang, C.A., Thiering, E., Wu, B., Kress, S., Kothalawala, D.M., Kadalayil, L., Duan, J., Zhang, H., Hadebe, S., Hoffmann, T., Jorgenson, E., Choquet, H., Risch, N., Njølstad, P., Andreassen, O.A., Johansson, S., Almqvist, C., Gong, T., Ullemar, V., Karlsson, R., Magnusson, P.K.E., Szwajda, A., Burchard, E.G., Thyssen, J.P., Hansen, T., Kårhus, L.L., Dantoft, T.M., Jeanrenaud, A.C.S.N., Ghauri, A., Arnold, A., Homuth, G., Lau, S., Nöthen, M.M., Hübner, N., Imboden, M., Visconti, A., Falchi, M., Bataille, V., Hysi, P., Ballardini, N., Boomsma, D.I., Hottenga, J.J., Müller-Nurasyid, M., Ahluwalia, T.S., Stokholm, J., Chawes, B., Schoos, A.M.M., Esplugues, A., Bustamante, M., Raby, B., Arshad, S., German, C., Esko, T., Milani, L.A., Metspalu, A., Terao, C., Abuabara, K., Løset, M., Hveem, K., Jacobsson, B., Pino-Yanes, M., Strachan, D.P., Grarup, N., Linneberg, A., Lee, Y., Probst-Hensch, N., Weidinger, S., Jarvelin, M.R., Melén, E., Hakonarson, H., Irvine, A.D., Jarvis, D., Nijsten, T., Duijts, L., Vonk, J.M., Koppelmann, G.H., Godfrey, K.M., Barton, S.J., Feenstra, B., Pennell, C.E., Sly, P.D., Holt, P.G., Williams, L.K., Bisgaard, H., Bønnelykke, K., Curtin, J., Simpson, A., Murray, C., Schikowski, T., Bunyavanich, S., Weiss, S.T., Holloway, J.W., Min, J.L., Brown, S.J., Standl, M. and Paternoster, L.
Nature Communications 14 (1): 6172. 4 October 2023

Play and tickling responses map to the lateral columns of the rat periaqueductal gray.
Gloveli, N., Simonnet, J., Tang, W., Concha-Miranda, M., Maier, E., Dvorzhak, A., Schmitz, D. and Brecht, M.
Neuron 111 (19): 3041-3052. 4 October 2023

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T., Stolzenberg, S., Sticht, J., Wieczorek, M., Roske, Y., Günther, M., Dähn, S., Boesen, B.B., Calvo, M.M., Biese, C., Kuppler, F., Medina-García, Á., Álvaro-Benito, M., Höfer, T., Noé, F. and Freund, C.
Nature Chemical Biology 19 (10): 1196-1204. October 2023

Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Eifert, T., Hsu, C.J., Becker, A.L., Graessle, S., Horne, A., Bemmann, F., Zhang, Q., Heuser, M., Vasioukhin, V., Scholl, S., Hochhaus, A., Siegerist, F., Endlich, N., Bullinger, L., Lane, S.W., Haas, S., Schnoeder, T.M and Heidel, F.H.
Leukemia 37 (10): 2027-2035. October 2023

Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20 (10): 1544-1552. October 2023

Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.
Cui, L., Yang, B., Xiao, S., Gao, J., Baud, A., Graham, D., McBride, M., Dominiczak, A., Schafer, S., Aumatell, R.L., Mont, C., Teruel, A.F., Hübner, N., Flint, J., Mott, R. and Huang, L.
Genome Biology 24 (1): 215. 29 September 2023

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
Rejeski, K., Perez, A., Iacoboni, G., Blumenberg, V., Bücklein, V.L., Völkl, S., Penack, O., Albanyan, O., Stock, S., Müller, F., Karschnia, P., Petrera, A., Reid, K., Faramand, R., Davila, M.L., Modi, K., Dean, E.A., Bachmeier, C., von Bergwelt-Baildon, M., Locke, F.L., Bethge, W., Bullinger, L., Mackensen, A., Barba, P., Jain, M.D. and Subklewe, M.
Science Advances 9 (38): eadg3919. 22 September 2023

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S.K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J.E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M.T., Hoyles, L., Alves, R., Helft, G., Isnard, R., Køber, L., Coelho, L.P., Rouault, C., Gauguier, D., Gøtze, J.P., Prifti, E., Froguel, P., Zucker, J.D., Bäckhed, F., Vestergaard, H., Hansen, T., Oppert, J.M., Blüher, M., Nielsen, J., Raes, J., Bork, P., Yaqoob, M.M., Stumvoll, M., Pedersen, O., Ehrlich, S.D., Clément, K. and Dumas, M.E.
Nature Communications 14 (1): 5843. 20 September 2023

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A.L., Tchenio, A., Benson, S., Vendrell, M., D'Alessandro, A., Beule, D., Pellerin, L., Mameli, M. and Paolicelli, R.C.
Nature Communications 14 (1): 5749. 16 September 2023

Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases.
Sun, C., Chen, J., Jin, M., Zhao, X., Li, Y., Dong, Y., Gao, N., Liu, Z., Bork, P., Zhao, X.M. and Chen, W.H.
Advanced Science 10 (25): 2302159. 5 September 2023

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.
Schoeler, M., Ellero-Simatos, S., Birkner, T., Mayneris-Perxachs, J., Olsson, L., Brolin, H., Löber, U., Kraft, J.D., Polizzi, A., Martí-Navas, M., Puig, J., Moschetta, A., Montagner, A., Gourdy, P., Heymes, C., Guillou, H., Tremaroli, V., Fernández-Real, J.M., Forslund, S.K., Burcelin, R. and Caesar, R.
Nature Communications 14 (1): 5329. 1 September 2023

Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire.
Anker, M.S., Potthoff, S.K., Lena, A., Porthun, J., Hadzibegovic, S., Evertz, R., Denecke, C., Fröhlich, A.K., Sonntag, F., Regitz-Zagrosek, V., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Spertus, J.A., Anker, S.D., Karakas, M., Bullinger, L., Keller, U., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure 25 (9): 1635-1647. September 2023

Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.
Tschernoster, N., Erger, F., Kohl, S., Reusch, B., Wenzel, A., Walsh, S., Thiele, H., Becker, C., Franitza, M., Bartram, M.P., Kömhoff, M., Schumacher, L., Kukat, C., Borodina, T., Quedenau, C., Nürnberg, P., Rinschen, M.M., Driller, J.H., Pedersen, B.P., Schlingmann, K.P., Hüttel, B., Bockenhauer, D., Beck, B. and Altmüller, J.
Genome Medicine 15 (1): 62. 23 August 2023

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A., Latorre, J., Serena-Maione, A., Espadas, I., Caballano-Infantes, E., Moreno-Navarrete, J.M., Oliveras-Cañellas, N., Ricart, W., Malagón, M.M., Martin-Montalvo, A., Birchmeier, W., Szymanski, W., Graumann, J., Gómez-Serrano, M., Sommariva, E., Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14 (1): 5106. 22 August 2023

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
John, L., Poos, A.M., Brobeil, A., Schinke, C., Huhn, S., Prokoph, N., Lutz, R., Wagner, B., Zangari, M., Tirier, S.M., Mallm, J.P., Schumacher, S., Vonficht, D., Solé-Boldo, L., Quick, S., Steiger, S., Przybilla, M.J., Bauer, K., Baumann, A., Hemmer, S., Rehnitz, C., Lückerath, C., Sachpekidis, C., Mechtersheimer, G., Haberkorn, U., Dimitrakopoulou-Strauss, A., Reichert, P., Barlogie, B., Müller-Tidow, C., Goldschmidt, H., Hillengass, J., Rasche, L., Haas, S.F., van Rhee, F., Rippe, K., Raab, M.S., Sauer, S. and Weinhold, N.
Nature Communications 14 (1): 5011. 17 August 2023

Enterotypes of the human gut mycobiome.
Lai, S., Yan, Y., Pu, Y., Lin, S., Qiu, J.G., Jiang, B.H., Keller, M.I., Wang, M., Bork, P., Chen, W.H., Zheng, Y. and Zhao, X.M.
Microbiome 11 (1): 179. 11 August 2023

mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons.
Loedige, I., Baranovskii, A., Mendonsa, S., Dantsuji, S., Popitsch, N., Breimann, L., Zerna, N., Cherepanov, V., Milek, M., Ameres, S. and Chekulaeva, M.
Molecular Cell 83 (15): 2709-2725. 3 August 2023

Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering.
Liu, C.C., Greenwald, N.F., Kong, A., McCaffrey, E.F., Leow, K.X., Mrdjen, D., Cannon, B.J., Rumberger, J.L., Varra, S.R. and Angelo, M.
Nature Communications 14 (1): 4618. 1 August 2023

Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
Schaupp, L., Addante, A., Völler, M., Fentker, K., Kuppe, A., Bardua, M., Duerr, J., Piehler, L., Röhmel, J., Thee, S., Kirchner, M., Ziehm, M., Lauster, D., Haag, R., Gradzielski, M., Stahl, M., Mertins, P., Boutin, S., Graeber, S.Y. and Mall, M.A.
European Respiratory Journal 62 (2): 2202153. 1 August 2023

Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury.
Sanad, A.M., Qadri, F., Popova, E., Rodrigues, A.F., Heinbokel, T., Quach, S., Schulz, A., Bachmann, S., Kreutz, R., Alenina, N. and Bader, M.
Kidney International 104 (2): 293-304. August 2023

Spatially resolved multiomics of human cardiac niches.
Kanemaru, K., Cranley, J., Muraro, D., Miranda, A.M.A., Ho, S.Y., Wilbrey-Clark, A., Patrick Pett, J., Polanski, K., Richardson, L., Litvinukova, M., Kumasaka, R., Qin, Y., Jablonska, Z., Semprich, C.I., Mach, L., Dabrowska, M., Richoz, R., Bolt, L., Mamanova, L., Kapuge, R., Barnett, S.N., Perera, S., Talavera-López, C., Mulas, I., Mahbubani, K.T., Tuck, Liz, Wang, Lu, Huang, M.M., Prete, M., Pritchard, S., Dark, J., Saeb-Parsy, K., Patel, M., Clatworthy, M.R., Hübner, N., Chowdhury, R.A., Noseda, M. and Teichmann, S.A.
Nature 619 : 801-810. 27 July 2023

SODAR: managing multiomics study data and metadata.
Nieminen, M., Stolpe, O., Kuhring, M., Weiner, J., Pett, P., Beule, D. and Holtgrewe, M.
GigaScience 12 : giad052. 27 July 2023

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.
Schubert, M.L., Schmitt, A., Hückelhoven-Krauss, A., Neuber, B., Kunz, A., Waldhoff, P., Vonficht, D., Yousefian, S., Jopp-Saile, L., Wang, L., Korell, F., Keib, A., Michels, B., Haas, D., Sauer, T., Derigs, P., Kulozik, A., Kunz, J., Pavel, P., Laier, S., Wuchter, P., Schmier, J., Bug, G., Lang, F., Gökbuget, N., Casper, J., Görner, M., Finke, J., Neubauer, A., Ringhoffer, M., Wolleschak, D., Brüggemann, M., Haas, S., Ho, A.D., Müller-Tidow, C., Dreger, P. and Schmitt, M.
Journal of Hematology & Oncology 16 (1): 79. 22 July 2023

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
Ziegler, K.A., Ahles, A., Dueck, A., Esfandyari, D., Pichler, P., Weber, K., Kotschi, S., Bartelt, A., Sinicina, I., Graw, M., Leonhardt, H., Weckbach, L.T., Massberg, S., Schifferer, M., Simons, M., Hoeher, L., Luo, J., Ertürk, A., Schiattarella, G.G., Sassi, Y., Misgeld, T. and Engelhardt, S.
Science 381 (6655): 285-290. 21 July 2023

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15 (1): 50. 20 July 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J., Rodríguez-Martínez, M., Fenzl, K., Hinze, F., Schraivogel, D., Grosch, M., Tunaj, B., Lindenhofer, D., Schraft, L., Kueblbeck, M., Smith, E., Mao, C., Brown, E., Owens, A., Saguner, A.M., Meder, B., Parikh, V., Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14 (1): 4312. 18 July 2023

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh, Y.T., Sona, C., Yan, X., Li, Y., Pathak, A., McDermott, M.I., Xie, Z., Liu, L., Arunagiri, A., Wang, Y., Cazenave-Gassiot, A., Ghosh, A., von Meyenn, F., Kumarasamy, S., Najjar, S.M., Jia, S., Wenk, M.R., Traynor-Kaplan, A., Arvan, P., Barg, S., Bankaitis, V.A. and Poy, M.N.
Nature Communications 14 (1): 4250. 17 July 2023

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Griger, J., Widholz, S.A., Jesinghaus, M., de Andrade Krätzig, N., Lange, S., Engleitner, T., Montero, J.J., Zhigalova, E., Öllinger, R., Suresh, V., Winkler, W., Lier, S., Baranov, O., Trozzo, R., Ben Khaled, N., Chakraborty, S., Yu, J., Konukiewitz, B., Steiger, K., Pfarr, N., Rajput, A., Sailer, D., Keller, G., Schirmacher, P., Röcken, C., Fagerstedt, K.W., Mayerle, J., Schmidt-Supprian, M., Schneider, G., Weichert, W., Calado, D.P., Sommermann, T., Klöppel, G., Rajewsky, K., Saur, D. and Rad, R.
Cancer Cell 41 (7): 1327-1344.e10. 10 July 2023

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C., Berger, H., Liu, L., Mollenkopf, H.J., Strowig, T. and Sigal, M.
Gut Microbes 15 (1): 2233689. 10 July 2023

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Jiang, Q., Stachelscheid, J., Bloehdorn, J., Pacholewska, A., Aszyk, C.M., Grotenhuijs, F., Müller, T.A., Onder, O., Wagle, P., Herling, C.D., Kleppe, M., Wang, Z., Coombes, K.R., Robrecht, S., Dalvi, P.S., Plosnita, B., Mayer, P., Abruzzo, L.V., Altmüller, J., Gathof, B.S., Persigehl, T., Fischer, K., Jebaraj, B.M.C., Rienhoff, H.Y., Ecker, R.C., Zhao, Y., Bruns, C.J., Stilgenbauer, S., Elenitoba-Johnson, K.S.J., Hallek, M., Schweiger, M.R., Odenthal, M., Vasyutina, E. and Herling, M.
Blood 142 (1): 44-61. 6 July 2023

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J., Costanzo, M., Sanaki-Matsumiya, M., Girardot, C., Hayashi, M., Hayashi, K., Diecke, S., Hildebrandt, T.B., Lazzari, G., Wu, J., Petkov, S., Behr, R., Trivedi, V., Matsuda, M. and Ebisuya, M.
Cell Stem Cell 30 (7): 938-949.e7. 6 July 2023

e-RNA: a collection of web-servers for the prediction and visualisation of RNA secondary structure and their functional features.
Tsybulskyi, V., Semenchenko, E. and Meyer, I.M.
Nucleic Acids Research 51 (W1): W160-W167. 5 July 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Samuelsson, A.M., Bartolomaeus, T.U.P., Anandakumar, H., Thowsen, I., Nikpey, E., Han, J., Marko, L., Finne, K., Tenstad, O., Eckstein, J., Berndt, N., Kühne, T., Kedziora, S., Sultan, I., Skogstrand, T., Karlsen, T.V., Nurmi, H., Forslund, S.K., Bollano, E., Alitalo, K., Muller, D.N. and Wiig, H.
Cardiovascular Research 119 (7): 1553-1567. 4 July 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Beagrie, R.A., Thieme, C.J., Annunziatella, C., Baugher, C., Zhang, Y., Schueler, M., Kukalev, A., Kempfer, R., Chiariello, A.M., Bianco, S., Li, Y., Davis, T., Scialdone, A., Welch, L.R., Nicodemi, M. and Pombo, A.
Nature Methods 20 (7): 1037-1047. July 2023

Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
Bech, J.M., Terkelsen, T., Bartels, A.S., Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G.I., Fang, X., Mann, M. and Moreira, J.M.A.
Gastroenterology 165 (1): 121-132.e5. July 2023

Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09-09): a randomised, open-label, multicentre, phase 3 trial.
Döhner, H., Weber, D., Krzykalla, J., Fiedler, W., Kühn, M.W.M., Schroeder, T., Mayer, K., Lübbert, M., Wattad, M., Götze, K., Fransecky, L., Koller, E., Wulf, G., Schleicher, J., Ringhoffer, M., Greil, R., Hertenstein, B., Krauter, J., Martens, U.M., Nachbaur, D., Samra, M.A., Machherndl-Spandl, S., Basara, N., Leis, C., Schrade, A., Kapp-Schwoerer, S., Cocciardi, S., Bullinger, L., Thol, F., Heuser, M., Paschka, P., Gaidzik, V.I., Saadati, M., Benner, A., Schlenk, R.F., Döhner, K. and Ganser, A.
Lancet Haematology 10 (7): e495-e509. July 2023

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.
Lareau, C.A., Dubois, S.M., Buquicchio, F.A., Hsieh, Y.H., Garg, K., Kautz, P., Nitsch, L., Praktiknjo, S.D., Maschmeyer, P., Verboon, J.M., Gutierrez, J.C., Yin, Y., Fiskin, E., Luo, W., Mimitou, E.P., Muus, C., Malhotra, R., Parikh, S., Fleming, M.D., Oevermann, L., Schulte, J., Eckert, C., Kundaje, A., Smibert, P., Vardhana, S.A., Satpathy, A.T., Regev, A., Sankaran, V.G., Agarwal, S. and Ludwig, L.S.
Nature Genetics 55 (7): 1198-1209. July 2023

Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8 (7): 1252-1266. July 2023

Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury.
Sieckmann, T., Schley, G., Ögel, N., Kelterborn, S., Boivin, F.J., Fähling, M., Ashraf, M.I., Reichel, M., Vigolo, E., Hartner, A., Lichtenberger, F.B., Breiderhoff, T., Knauf, F., Rosenberger, C., Aigner, F., Schmidt-Ott, K., Scholz, H. and Kirschner, K.M.
Kidney International 104 (1): 90-107. July 2023

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses.
Jiang, B., Schmitt, M.J., Rand, U., Company, C., Dramaretska, Y., Grossmann, M., Serresi, M., Cicin-Sain, L. and Gargiulo, G.
Science Advances 9 (25): eadf4975. 23 June 2023

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
Milenkovic, I., Santos Vieira, H.G., Lucas, M.C., Ruiz-Orera, J., Patone, G., Kesteven, S., Wu, J., Feneley, M., Espadas, G., Sabidó, E., Hübner, N., van Heesch, S., Völkers, M. and Novoa, E.M.
Nucleic Acids Research 51 (11): 5301-5324. 23 June 2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M., Schraft, L., Chan, A., Küchenhoff, L., Rapti, K., Ferreira, A.M., Kornienko, J., Li, S., Radke, M.H., Krämer, C., Clauder-Münster, S., Perlas, E., Backs, J., Gotthardt, M., Dieterich, C., van den Hoogenhof, M.M.G., Grimm, D. and Steinmetz, L.M.
Nature Communications 14 (1): 3714. 22 June 2023

Transcription factor induction of vascular blood stem cell niches in vivo.
Hagedorn, E.J., Perlin, J.R., Freeman, R.J., Wattrus, S.J., Han, T., Mao, C., Kim, J.W., Fernández-Maestre, I., Daily, M.L., D'Amato, C., Fairchild, M.J., Riquelme, R., Li, B., Ragoonanan, D.A.V.E., Enkhbayar, K., Henault, E.L., Wang, H.G., Redfield, S.E., Collins, S.H., Lichtig, A., Yang, S., Zhou, Y., Kunar, B., Gomez-Salinero, J.M., Dinh, T.T., Pan, J., Holler, K., Feldman, H.A., Butcher, E.C., van Oudenaarden, A., Rafii, S., Junker, J.P. and Zon, L.I.
Developmental Cell 58 (12): 1037-1051. 19 June 2023

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.
Bonifacius, A., Lamottke, B., Tischer-Zimmermann, S., Schultze-Florey, R., Goudeva, L., Heuft, H.G., Arseniev, L., Beier, R., Beutel, G., Cario, G., Fröhlich, B., Greil, J., Hansmann, L., Hasenkamp, J., Höfs, M., Hundsdoerfer, P., Jost, E., Kafa, K., Kriege, O., Kröger, N., Mathas, S., Meisel, R., Nathrath, M., Putkonen, M., Ravens, S., Reinhardt, H.C., Sala, E., Sauer, M.G, Schmitt, C., Schroers, R., Steckel, N.K., Trappe, R.U., Verbeek, M., Wolff, D., Blasczyk, R., Eiz-Vesper, B. and Maecker-Kolhoff, B.
Journal of Clinical Investigation 133 (12): e163548. 15 June 2023

A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C., Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S., Tajbakhsh, S., Höpken, U.E. and Stricker, S.
Immunity 56 (6): 1204-1219. 13 June 2023

Functional analysis of structural variants in single cells using Strand-seq.
Jeong, H., Grimes, K., Rauwolf, K.K., Bruch, P.M., Rausch, T., Hasenfeld, P., Benito, E., Roider, T., Sabarinathan, R., Porubsky, D., Herbst, S.A., Erarslan-Uysal, B., Jann, J.C., Marschall, T., Nowak, D., Bourquin, J.P., Kulozik, A.E., Dietrich, S., Bornhauser, B., Sanders, A.D. and Korbel, J.O.
Nature Biotechnology 41 (6): 832-844. June 2023

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang, G., Chiou, J., Zeng, C., Miller, M., Matta, I., Han, J.Y., Kadakia, N., Okino, M.L., Beebe, E., Mallick, M., Camunas-Soler, J., Dos Santos, T., Dai, X.Q., Ellis, C., Hang, Y., Kim, S.K., MacDonald, P.E., Kandeel, F.R., Preissl, S., Gaulton, K.J. and Sander, M.
Nature Genetics 55 (6): 984-994. June 2023

Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H.C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N. and Hilgers, V.
Cell 186 (11): 2438-2455. 25 May 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14 (1): 3025. 25 May 2023

Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
Haueise, T., Schick, F., Stefan, N., Schlett, C.L., Weiss, J.B., Nattenmüller, J., Göbel-Guéniot, K., Norajitra, T., Nonnenmacher, T., Kauczor, H.U., Maier-Hein, K.H., Niendorf, T., Pischon, T., Jöckel, K.H., Umutlu, L., Peters, A., Rospleszcz, S., Kröncke, T., Hosten, N., Völzke, H., Krist, L., Willich, S.N., Bamberg, F. and Machann, J.
Science Advances 9 (19): eadd0433. 12 May 2023

Recombination between heterologous human acrocentric chromosomes.
Guarracino, A., Buonaiuto, S., de Lima, L.G., Potapova, T., Rhie, A., Koren, S., Rubinstein, B., Fischer, C., Gerton, J.L., Phillippy, A.M., Colonna, V. and Garrison, E.
Nature 617 (7960): 335-343. 11 May 2023

A draft human pangenome reference.
Liao, W.W., Asri, M., Ebler, J., Doerr, D., Haukness, M., Hickey, G., Lu, S., Lucas, J.K., Monlong, J., Abel, H.J., Buonaiuto, S., Chang, X.H., Cheng, H., Chu, J., Colonna, V., Eizenga, J.M., Feng, X., Fischer, C., Fulton, R.S., Garg, S., Groza, C., Guarracino, A., Harvey, W.T., Heumos, S., Howe, K., Jain, M., Lu, T.Y., Markello, C., Martin, F.J., Mitchell, M.W., Munson, K.M., Mwaniki, M.N., Novak, A.M., Olsen, H.E., Pesout, T., Porubsky, D., Prins, P., Sibbesen, J.A., Sirén, J., Tomlinson, C., Villani, F., Vollger, M.R., Antonacci-Fulton, L.L., Baid, G., Baker, C.A., Belyaeva, A., Billis, K., Carroll, A., Chang, P.C., Cody, S., Cook, D.E., Cook-Deegan, R.M., Cornejo, O.E., Diekhans, M., Ebert, P., Fairley, S., Fedrigo, O., Felsenfeld, A.L., Formenti, G., Frankish, A., Gao, Yan, Garrison, N.A., Giron, C.G., Green, R.E., Haggerty, L., Hoekzema, K., Hourlier, T., Ji, H.P., Kenny, E.E., Koenig, B.A., Kolesnikov, A., Korbel, J.O., Kordosky, J., Koren, S., Lee, H.J., Lewis, A.P., Magalhães, H., Marco-Sola, S., Marijon, P., McCartney, A., McDaniel, J., Mountcastle, J., Nattestad, M., Nurk, S., Olson, N.D., Popejoy, A.B., Puiu, D., Rautiainen, M., Regier, A.A., Rhie, A., Sacco, S., Sanders, A.D., Schneider, V.A., Schultz, B.I., Shafin, K., Smith, M.W., Sofia, H.J., Abou Tayoun, A.N., Thibaud-Nissen, F., Tricomi, F.F., Wagner, J., Walenz, B., Wood, J.M.D., Zimin, A.V., Bourque, G., Chaisson, M.J P, Flicek, Paul, Phillippy, A.M., Zook, J.M., Eichler, E.E., Haussler, D., Wang, T., Jarvis, E.D., Miga, K.H., Garrison, E., Marschall, T., Hall, I.M., Li, H. and Paten, B.
Nature 617 (7960): 312-324. 11 May 2023

Increased mutation and gene conversion within human segmental duplications.
Vollger, M.R., Dishuck, P.C., Harvey, W.T., DeWitt, W.S., Guitart, X., Goldberg, M.E., Rozanski, A.N., Lucas, J., Asri, M., Munson, K.M., Lewis, A.P., Hoekzema, K., Logsdon, G.A., Porubsky, D., Paten, B., Harris, K., Hsieh, P.H. and Eichler, E.E.
Nature 617 (7960): 325-334. 11 May 2023

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia.
Beneyto-Calabuig, S., Merbach, A.K., Kniffka, J.A., Antes, M., Szu-Tu, C., Rohde, C., Waclawiczek, A., Stelmach, P., Gräßle, S., Pervan, P., Janssen, M., Landry, J.J.M., Benes, V., Jauch, A., Brough, M., Bauer, M., Besenbeck, B., Felden, J., Bäumer, S., Hundemer, M., Sauer, T., Pabst, C., Wickenhauser, C., Angenendt, L., Schliemann, C., Trumpp, A., Haas, S., Scherer, M., Raffel, S., Müller-Tidow, C. and Velten, L.
Cell Stem Cell 30 (5): 706-721. 4 May 2023

Interferon-γ drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload.
Apaydin, D.C., Zakarauskas-Seth, B.I., Carnevale, L., Apaydin, O., Perrotta, M., Carnevale, R., Kotini, M.P., Kotlar-Goldaper, I., Belting, H.G., Carnevale, D., Filosa, A. and Sawamiphak, S.
Cardiovascular Research 119 (5): 1234-1249. May 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55 (5): 880-890. May 2023

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H., Schöberl, F., Giurgiu, M., Leal Silva, R.M., Scholz, V., Scharf, F., Wendlandt, M., Kleinle, S., Deschauer, M., Nübling, G., Heide, W., Babacan, S.S., Schneider, C., Neuhann, T., Hahn, K., Schoser, B., Holinski-Feder, E., Wolf, D.A. and Abicht, A.
Brain 146 (5): 1831-1843. May 2023

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.
Lareau, C.A., Liu, V., Muus, C., Praktiknjo, S.D., Nitsch, L., Kautz, P., Sandor, K., Yin, Y., Gutierrez, J.C., Pelka, K., Satpathy, A.T., Regev, A., Sankaran, V.G. and Ludwig, L.S.
Nature Protocols 18 (5): 1416-1440. May 2023

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles, G., Adler, J.M., Pennitz, P., Peidli, S., Teixeira Alves, L.G., Baumgardt, M., Bushe, J., Voss, A., Langenhagen, A., Langner, C., Martin Vidal, R., Pott, F., Kazmierski, J., Ebenig, A., Lange, M.V., Mühlebach, M.D., Goekeri, C., Simmons, S., Xing, N., Abdelgawad, A., Herwig, S., Cichon, G., Niemeyer, D., Drosten, C., Goffinet, C., Landthaler, M., Blüthgen, N., Wu, H., Witzenrath, M., Gruber, A.D., Praktiknjo, S.D., Osterrieder, N., Wyler, E., Kunec, D. and Trimpert, J.
Nature Microbiology 8 (5): 860-874. May 2023

Inversion polymorphism in a complete human genome assembly.
Porubsky, D., Harvey, W.T., Rozanski, A.N., Ebler, J., Höps, W., Ashraf, H., Hasenfeld, P., Paten, B., Sanders, A.D., Marschall, T., Korbel, J.O. and Eichler, E.E.
Genome Biology 24 (1): 100. 30 April 2023

Clinical and prognostic relevance of cardiac wasting in patients with advanced cancer.
Lena, A., Wilkenshoff, U., Hadzibegovic, S., Porthun, J., Rösnick, L., Fröhlich, A.K., Zeller, T., Karakas, M., Keller, U., Ahn, J., Bullinger, L., Riess, H., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Totzeck, M., Rassaf, T., Burkhoff, D., Mehra, M.R., Bax, J.J., Butler, J., Edelmann, F., Haverkamp, W., Anker, S.D., Packer, M., Coats, A.J.S., von Haehling, S., Landmesser, U. and Anker, M.S.
Journal of the American College of Cardiology 81 (16): 1569-1586. 25 April 2023

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Abbosh, C., Frankell, A.M., Harrison, T., Kisistok, J., Garnett, A., Johnson, L., Veeriah, S., Moreau, M., Chesh, A., Chaunzwa, T.L., Weiss, J., Schroeder, M.R., Ward, S., Grigoriadis, K., Shahpurwalla, A., Litchfield, K., Puttick, C., Biswas, D., Karasaki, T., Black, J.R.M., Martínez-Ruiz, C., Bakir, M.A.l., Pich, O., Watkins, T.B.K., Lim, E.L., Huebner, A., Moore, D.A., Godin-Heymann, N., L'Hernault, A., Bye, H., Odell, A., Roberts, P., Gomes, F., Patel, A.J., Manzano, E., Hiley, C.T., Carey, N., Riley, J., Cook, D.E., Hodgson, D., Stetson, D., Barrett, J.C., Kortlever, R.M., Evan, G.I., Hackshaw, A., Daber, R.D., Shaw, J.A., Aerts, H.J.W.L., Licon, A., Stahl, J., Jamal-Hanjani, M., Birkbak, N.J., McGranahan, N. and Swanton, C.
Nature 616 (7957): 553-562. 20 April 2023

The evolution of lung cancer and impact of subclonal selection in TRACERx.
Frankell, A.M., Dietzen, M., Al Bakir, M., Lim, E.L., Karasaki, T., Ward, S., Veeriah, S., Colliver, E., Huebner, A., Bunkum, A., Hill, M.S., Grigoriadis, K., Moore, D.A., Black, J.R.M., Liu, W.K., Thol, K., Pich, O., Watkins, T.B.K., Naceur-Lombardelli, C., Cook, D.E., Salgado, R., Wilson, G.A., Bailey, C., Angelova, M., Bentham, R., Martínez-Ruiz, C., Abbosh, C., Nicholson, A.G., Le Quesne, J., Biswas, D., Rosenthal, R., Puttick, C., Hessey, S., Lee, C., Prymas, P., Toncheva, A., Smith, J., Xing, W., Nicod, J., Price, G., Kerr, K.M., Naidu, B., Middleton, G., Blyth, K.G., Fennell, D.A., Forster, M.D., Lee, S.M., Falzon, M., Hewish, M., Shackcloth, M.J., Lim, E., Benafif, S., Russell, P., Boleti, E., Krebs, M.G., Lester, J.F., Papadatos-Pastos, D., Ahmad, T., Thakrar, R.M., Lawrence, D., Navani, N., Janes, S.M., Dive, C., Blackhall, F.H, Summers, Y., Cave, J., Marafioti, T., Herrero, J., Quezada, S.A., Peggs, K.S., Schwarz, R.F., Van Loo, P., Miedema, D.M., Birkbak, N.J., Hiley, C.T., Hackshaw, A., Zaccaria, S., Jamal-Hanjani, M., McGranahan, N. and Swanton, C.
Nature 616 (7957): 525-533. 20 April 2023

The little skate genome and the evolutionary emergence of wing-like fins.
Marlétaz, F., de la Calle-Mustienes, E., Acemel, R.D., Paliou, C., Naranjo, S., Martínez-García, P.M., Cases, I., Sleight, V.A., Hirschberger, C., Marcet-Houben, M., Navon, D., Andrescavage, A., Skvortsova, K., Duckett, P.Ed., González-Rajal, Á., Bogdanovic, O., Gibcus, J.H., Yang, L., Gallardo-Fuentes, L., Sospedra, I., Lopez-Rios, J., Darbellay, F., Visel, A., Dekker, J., Shubin, N., Gabaldón, T., Nakamura, T., Tena, J.J., Lupianez, D.G., Rokhsar, D.S. and Gómez-Skarmeta, J.L.
Nature 616 (7957): 495-503. 20 April 2023

Genomic–transcriptomic evolution in lung cancer and metastasis.
Martínez-Ruiz, C., Black, J.R.M., Puttick, C., Hill, M.S., Demeulemeester, J., Larose Cadieux, E., Thol, K., Jones, T.P., Veeriah, S., Naceur-Lombardelli, C., Toncheva, A., Prymas, P., Rowan, A., Ward, S., Cubitt, L., Athanasopoulou, F., Pich, O., Karasaki, T., Moore, D.A., Salgado, R., Colliver, E., Castignani, C., Dietzen, M., Huebner, A., Al Bakir, M., Tanić, M., Watkins, T.B.K., Lim, E.L., Al-Rashed, A.M., Lang, D., Clements, J., Cook, D.E., Rosenthal, R., Wilson, G. A., Frankell, A.M., de Carné Trécesson, S., East, P., Kanu, N., Litchfield, K., Birkbak, N.J., Hackshaw, A., Beck, S., Van Loo, P., Jamal-Hanjani, M., McGranahan, N. and Swanton, C.
Nature 616 (7957): 543-552. 20 April 2023

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng, K.W., Boumelha, J., Enfield, K.S.S., Almagro, J., Cha, H., Pich, O., Karasaki, T., Moore, D.A., Salgado, R., Sivakumar, M., Young, G., Molina-Arcas, M., de Carné Trécesson, S., Anastasiou, P., Fendler, A., Au, L., Shepherd, S.T.C., Martínez-Ruiz, C., Puttick, C., Black, J.R.M., Watkins, T.B.K., Kim, H., Shim, S., Faulkner, N., Attig, J., Veeriah, S., Magno, N., Ward, S., Frankell, A.M., Al Bakir, M., Lim, E.L., Hill, M.S., Wilson, G.A., Cook, D.E., Birkbak, N.J., Behrens, A., Yousaf, N., Popat, S., Hackshaw, A., Hiley, C.T., Litchfield, K., McGranahan, N., Jamal-Hanjani, M., Larkin, J., Lee, S.H., Turajlic, S., Swanton, C., Downward, J. and Kassiotis, G.
Nature 616 (7957): 563-573. 20 April 2023

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch, T., Snajder, R., Leger, A., Simovic, M., Giurgiu, M., Villacorta, L., Henssen, A.G., Fröhling, S., Stegle, O., Birney, E., Bonder, M.J., Ernst, A. and Korbel, J.O.
Cell Genomics 3 (4): 100281. 12 April 2023

A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
Huljev, K., Shamipour, S., Pinheiro, D., Preusser, F., Steccari, I., Sommer, C.M., Naik, S. and Heisenberg, C.P.
Developmental Cell 58 (7): 582-596.e7. 10 April 2023

Lung adenocarcinoma promotion by air pollutants.
Hill, W., Lim, E.L., Weeden, C.E., Lee, C., Augustine, M., Chen, K., Kuan, F.C., Marongiu, F., Evans, E.J., Moore, D.A., Rodrigues, F.S., Pich, O., Bakker, B., Cha, H., Myers, R., van Maldegem, F., Boumelha, J., Veeriah, S., Rowan, A., Naceur-Lombardelli, C., Karasaki, T., Sivakumar, M., De, S., Caswell, D.R., Nagano, A., Black, J.R.M., Martínez-Ruiz, C., Ryu, M.H., Huff, R.D., Li, S., Favé, M.J., Magness, A., Suárez-Bonnet, A., Priestnall, S.L., Lüchtenborg, M., Lavelle, K., Pethick, J., Hardy, S., McRonald, F.E., Lin, M.H., Troccoli, C.I., Ghosh, M., Miller, Y.E., Merrick, D.T., Keith, R.L., Al Bakir, M., Bailey, C., Hill, M.S., Saal, L.H., Chen, Y., George, A.M., Abbosh, C., Kanu, N., Lee, S.H., McGranahan, N., Berg, C.D., Sasieni, P., Houlston, R., Turnbull, C., Lam, S., Awadalla, P., Grönroos, E., Downward, J., Jacks, T., Carlsten, C., Malanchi, I., Hackshaw, A., Litchfield, K., DeGregori, J., Jamal-Hanjani, M. and Swanton, C.
Nature 616 (7955): 159-167. 6 April 2023