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| Item Type: | Article |
|---|---|
| Title: | Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly |
| Creators: |
Li, H.  ORCID: https://orcid.org/0000-0002-7332-7122, Janssens, J. ORCID: https://orcid.org/0000-0001-9264-0782, De Waegeneer, M. ORCID: https://orcid.org/0000-0002-4535-3737, Kolluru, S.S., Davie, K. ORCID: https://orcid.org/0000-0003-2182-1249, Gardeux, V. ORCID: https://orcid.org/0000-0001-8954-2161, Saelens, W. ORCID: https://orcid.org/0000-0002-7114-6248, David, F.P.A. ORCID: https://orcid.org/0000-0001-8539-865X, Brbić, M. ORCID: https://orcid.org/0000-0002-1120-1778, Spanier, K. ORCID: https://orcid.org/0000-0002-1375-4157, Leskovec, J. ORCID: https://orcid.org/0000-0002-5411-923X, McLaughlin, C.N. ORCID: https://orcid.org/0000-0002-7518-8920, Xie, Q. ORCID: https://orcid.org/0000-0002-0997-8326, Jones, R.C. ORCID: https://orcid.org/0000-0001-7235-9854, Brueckner, K., Shim, J. ORCID: https://orcid.org/0000-0003-2409-1130, Tattikota, S.G. ORCID: https://orcid.org/0000-0003-0318-5533, Schnorrer, F. ORCID: https://orcid.org/0000-0002-9518-7263, Rust, K. ORCID: https://orcid.org/0000-0001-6367-5994, Nystul, T.G. ORCID: https://orcid.org/0000-0002-6250-2394, Carvalho-Santos, Zi. ORCID: https://orcid.org/0000-0001-7100-308X, Ribeiro, C. ORCID: https://orcid.org/0000-0002-9542-7335, Pal, S. ORCID: https://orcid.org/0000-0003-4840-3944, Mahadevaraju, S. ORCID: https://orcid.org/0000-0002-2807-5237, Przytycka, T.M. ORCID: https://orcid.org/0000-0002-6261-277X, Allen, A.M. ORCID: https://orcid.org/0000-0002-7961-4392, Goodwin, S.F. ORCID: https://orcid.org/0000-0002-0552-4140, Berry, C.W. ORCID: https://orcid.org/0000-0003-1096-2804, Fuller, M.T. ORCID: https://orcid.org/0000-0002-3804-4987, White-Cooper, H. ORCID: https://orcid.org/0000-0002-3373-8023, Matunis, E.L. ORCID: https://orcid.org/0000-0001-5439-4656, DiNardo, S. ORCID: https://orcid.org/0000-0003-4131-5511, Galenza, A. ORCID: https://orcid.org/0000-0001-9038-9483, O'Brien, L.E., Dow, J.A.T. ORCID: https://orcid.org/0000-0002-9595-5146, Jasper, H., Oliver, B. ORCID: https://orcid.org/0000-0002-3455-4891, Perrimon, N. ORCID: https://orcid.org/0000-0001-7542-472X, Deplancke, B. ORCID: https://orcid.org/0000-0001-9935-843X, Quake, S.R. ORCID: https://orcid.org/0000-0002-1613-0809, Luo, L. ORCID: https://orcid.org/0000-0001-5467-9264 and Aerts, S. ORCID: https://orcid.org/0000-0002-8006-0315
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| Abstract: | For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution. |
| Keywords: | Cell Nucleus, Genetic Databases, Gene Expression Regulation, Gene Regulatory Networks, Insect Genes, RNA-Seq, Sex Characteristics, Single-Cell Analysis, Transcription Factors, Transcriptome, Drosophila Proteins, Animals, Drosophila melanogaster |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 375 |
| Number: | 6584 |
| Page Range: | eabk2432 |
| Date: | 4 March 2022 |
| Additional Information: | Robert P. Zinzen is a member of the FCA Consortium. - Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. |
| Official Publication: | https://doi.org/10.1126/science.abk2432 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
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