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| Item Type: | Article |
|---|---|
| Title: | Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters |
| Creators: |
Nouailles, G.  ORCID: https://orcid.org/0000-0003-1973-3119, Adler, J.M. ORCID: https://orcid.org/0000-0001-8147-0351, Pennitz, P. ORCID: https://orcid.org/0000-0002-8132-7237, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Baumgardt, M. ORCID: https://orcid.org/0000-0003-2077-3716, Bushe, J., Voss, A., Langenhagen, A., Langner, C. ORCID: https://orcid.org/0000-0001-7311-3477, Martin Vidal, R. ORCID: https://orcid.org/0000-0002-9670-5640, Pott, F. ORCID: https://orcid.org/0000-0003-3700-1691, Kazmierski, J. ORCID: https://orcid.org/0000-0002-7962-2165, Ebenig, A. ORCID: https://orcid.org/0000-0001-7066-0184, Lange, M.V., Mühlebach, M.D. ORCID: https://orcid.org/0000-0002-7069-5018, Goekeri, C. ORCID: https://orcid.org/0000-0002-1616-4005, Simmons, S., Xing, N., Abdelgawad, A., Herwig, S., Cichon, G., Niemeyer, D. ORCID: https://orcid.org/0000-0002-1897-6365, Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, Goffinet, C. ORCID: https://orcid.org/0000-0002-3959-004X, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Wu, H., Witzenrath, M., Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Praktiknjo, S.D. ORCID: https://orcid.org/0000-0002-0186-5271, Osterrieder, N., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Kunec, D. ORCID: https://orcid.org/0000-0001-6697-7621 and Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810
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| Abstract: | Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 variants and the ability to reduce virus transmission. Here we compare immune responses and preclinical efficacy of the mRNA vaccine BNT162b2, the adenovirus-vectored spike vaccine Ad2-spike and the live-attenuated virus vaccine candidate sCPD9 in Syrian hamsters, using both homogeneous and heterologous vaccination regimens. Comparative vaccine efficacy was assessed by employing readouts from virus titrations to single-cell RNA sequencing. Our results show that sCPD9 vaccination elicited the most robust immunity, including rapid viral clearance, reduced tissue damage, fast differentiation of pre-plasmablasts, strong systemic and mucosal humoral responses, and rapid recall of memory T cells from lung tissue after challenge with heterologous SARS-CoV-2. Overall, our results demonstrate that live-attenuated vaccines offer advantages over currently available COVID-19 vaccines. |
| Keywords: | Live Attenuated Vaccines, Mucosal Immunology, SARS-CoV-2, Animals, Cricetinae |
| Source: | Nature Microbiology |
| ISSN: | 2058-5276 |
| Publisher: | Nature Publishing Group |
| Volume: | 8 |
| Number: | 5 |
| Page Range: | 860-874 |
| Date: | May 2023 |
| Official Publication: | https://doi.org/10.1038/s41564-023-01352-8 |
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