Global analysis of bacterial transcription factors to predict cellular target processes

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Item Type:	Article
Title:	Global analysis of bacterial transcription factors to predict cellular target processes
Creators:	Doerks, T., Andrade, M.A. ORCID: https://orcid.org/0000-0001-6650-1711, Lathe, W., von Mering, C. ORCID: https://orcid.org/0000-0001-7734-9102 and Bork, P. ORCID: https://orcid.org/0000-0002-2627-833X
Abstract:	Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.
Keywords:	Bacteria, Bacterial Genes, Bacterial Genome, Computational Biology, Conserved Sequence, Databases, Gene Order, Genomics, Multigene Family, Phylogeny, Transcription Factors
Source:	Trends in Genetics
ISSN:	0168-9525
Publisher:	Elsevier
Volume:	20
Number:	3
Page Range:	126-131
Date:	1 January 2004
Official Publication:	https://doi.org/10.1016/j.tig.2004.01.006
PubMed:	View item in PubMed

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