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Abdelilah-Seyfried, Salim |
Akalin, Altuna (BIMSB) |
Altmüller, Janine (BIMSB/BIH) |
Andrade Navarro, Miguel |
Bader, Michael |
Bargou, Ralf C. |
Behlke, Joachim |
Bergmann, Martin W. |
Besser, Daniel |
Beule, Dieter (MDC/BIH) |
Birchmeier, Walter |
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Blankenstein, Thomas |
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Calkhoven, Cornelis F. |
Cardoso, Cristina |
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Gerull, Brenda |
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Jentsch, Thomas |
Jordan, Jens |
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Staroßom, Sarah-Christin (ECRC) |
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Thierfelder, Ludwig |
Treier, Mathias |
Tursun, Baris (BIMSB) |
Uckert, Wolfgang |
Von Kries, Jens Peter / Nazaré, Marc |
Wallukat, Gerd |
Walther, Wolfgang |
Wang, Jichang |
Wanker, Erich |
Welfle, Heinz |
Wilck, Nicola (ECRC) |
Willnow, Thomas E. |
Wittmann-Liebold, Brigitte |
Woehler, Andrew (BIMSB) |
Wolf, Jana |
Wolf, Susanne |
Zampieri, Niccolo |
Zenke, Martin |
Ziebold, Ulrike |
Zimmermann, Hanna (ECRC) |
Zinzen, Robert (BIMSB) |
Zipp, FraukeAbdelilah-Seyfried, Salim
Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry.
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L. and Abdelilah-Seyfried, S.
Developmental Cell 24
(6): 660-667.
25 March 2013
Bmp signaling exerts opposite effects on cardiac differentiation.
de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M. and Bakkers, J.
Circulation Research 110
(4): 578-587.
17 February 2012
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Lange, M., Kaynak, B., Foerster, U.B., Toenjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S. and Sperling, S.
Genes & Development 22
(17): 2370-2384.
1 September 2008
Akalin, Altuna (BIMSB)
Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15
(1): 3146.
11 April 2024
The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
Benedum, J., Franke, V., Appel, L.M., Walch, L., Bruno, M., Schneeweiss, R., Gruber, J., Oberndorfer, H., Frank, E., Strobl, X., Polyansky, A., Zagrovic, B., Akalin, A. and Slade, D.
Nature Communications 14
(1): 7912.
30 November 2023
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14
(1): 6947.
7 November 2023
The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel, L.M., Franke, V., Benedum, J., Grishkovskaya, I., Strobl, X., Polyansky, A., Ammann, G., Platzer, S., Neudolt, A., Wunder, A., Walch, L., Kaiser, S., Zagrovic, B., Djinovic-Carugo, K., Akalin, A. and Slade, D.
Nature Communications 14
(1): 166.
11 January 2023
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N., Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A., André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M., Cui, C., Daumke, O., Del Bel, K.L., Eibel, H., Feng, X., Franke, V., Gebhardt, J.C.M., Götz, A., Grunwald, S., Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M., Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W., Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S., Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8
(79): eade7953.
January 2023
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C, Daub, C.O., Lenhard, B. and Müller, F.
Nature Genetics 54
(7): 1037-1050.
July 2022
Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J., Baranovskii, A., Ronen, J., Uyar, B., Franke, V. and Akalin, A.
Genome Biology 23
(1): 123.
30 May 2022
Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W., Akalin, A. and Ohler, U.
Nature Machine Intelligence 4
(2): 162-168.
February 2022
The SEQC2 epigenomics quality control (EpiQC) study.
Foox, J., Nordlund, J., Lalancette, C., Gong, T., Lacey, M., Lent, S., Langhorst, B.W., Ponnaluri, V.K.C., Williams, L., Padmanabhan, K.R., Cavalcante, R., Lundmark, A., Butler, D., Mozsary, C., Gurvitch, J., Greally, J.M., Suzuki, M., Menor, M., Nasu, M., Alonso, A., Sheridan, C., Scherer, A., Bruinsma, S., Golda, G., Muszynska, A., Łabaj, P.P., Campbell, M.A., Wos, F., Raine, A., Liljedahl, U., Axelsson, T., Wang, C., Chen, Z., Yang, Z., Li, J., Yang, X., Wang, H., Melnick, A., Guo, S., Blume, A., Franke, V., Ibanez de Caceres, I., Rodriguez-Antolin, C., Rosas, R., Davis, J.W., Ishii, J., Megherbi, D.B., Xiao, W., Liao, W., Xu, J., Hong, H., Ning, B., Tong, W., Akalin, A., Wang, Y., Deng, Y. and Mason, C.E.
Genome Biology 22
(1): 332.
6 December 2021
Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W., Kukalev, A., Harabula, I., Zea-Redondo, L., Szabó, D., Meijer, M., Serebreni, L., Zhang, Y., Bianco, S., Chiariello, A.M., Irastorza-Azcarate, I., Thieme, C.J., Sparks, T.M., Carvalho, S., Fiorillo, L., Musella, F., Irani, E., Triglia, E.T., Kolodziejczyk, A.A., Abentung, A., Apostolova, G., Paul, E.J., Franke, V., Kempfer, R., Akalin, A., Teichmann, S.A., Dechant, G., Ungless, M.A., Nicodemi, M., Welch, L., Castelo-Branco, G. and Pombo, A.
Nature 599
(7886): 684-691.
25 November 2021
PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M., Franke, V., Bruno, M., Grishkovskaya, I., Kasiliauskaite, A., Kaufmann, T., Schoeberl, U.E., Puchinger, M.G., Kostrhon, S., Ebenwaldner, C., Sebesta, M., Beltzung, E., Mechtler, K., Lin, G., Vlasova, A., Leeb, M., Pavri, R., Stark, A., Akalin, A., Stefl, R., Bernecky, C., Djinovic-Carugo, K. and Slade, D.
Nature Communications 12
(1): 6078.
19 October 2021
Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge.
Sieberts, S.K., Schaff, J., Duda, M., Pataki, B.Á., Sun, M., Snyder, P., Daneault, J.F., Parisi, F., Costante, G., Rubin, U., Banda, P., Chae, Y., Chaibub Neto, E., Dorsey, E.R., Aydın, Z., Chen, A., Elo, L.L., Espino, C., Glaab, E., Goan, E., Golabchi, F.N., Görmez, Y., Jaakkola, M.K., Jonnagaddala, J., Klén, R., Li, D., McDaniel, C., Perrin, D., Perumal, T.M., Rad, N.M., Rainaldi, E., Sapienza, S., Schwab, P., Shokhirev, N., Venäläinen, M.S., Vergara-Diaz, G., Zhang, Y., Wang, Y., Guan, Y., Brunner, D., Bonato, P., Mangravite, L.M. and Omberg, L.
NPJ Digital Medicine 4
(1): 53.
19 March 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M., Franke, V., Brandt, B., Lowenstein, E.D., Schöwel, V., Spuler, S., Akalin, A. and Birchmeier, C.
Nature Communications 11
: 6375.
11 December 2020
Single-cell analyses of aging, inflammation and senescence.
Uyar, B., Palmer, D., Kowald, A., Escobar, H.M., Barrantes, I., Möller, S., Akalin, A. and Fuellen, G.
Ageing Research Reviews 64
: 101156.
December 2020
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J., Isbilir, A., Sungkaworn, T., Osberg, B., Karathanasis, C., Sunkara, V., Grushevskyi, E.O., Bock, A., Annibale, P., Heilemann, M., Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16
(9): 946-954.
September 2020
Deep learning for genomics using Janggu.
Kopp, W., Monti, R., Tamburrini, A., Ohler, U. and Akalin, A.
Nature Communications 11
(1): 3488.
13 July 2020
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T., Yasuda, T., Ronen, J., Wirtz, T., Weber, T., Sack, U., Caeser, R., Zhang, J., Li, X., Chu, V.T., Jauch, A., Unger, K., Hodson, D.J., Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117
(25): 14421-14432.
23 June 2020
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E., Franke, V., Menegatti, J., Kocks, C., Boltengagen, A., Praktiknjo, S., Walch-Rückheim, B., Bosse, J., Rajewsky, N., Grässer, F., Akalin, A. and Landthaler, M.
Nature Communications 10
(1): 4878.
25 October 2019
HOT or not: examining the basis of high-occupancy target regions.
Wreczycka, K., Franke, V., Uyar, B., Wurmus, R., Bulut, S., Tursun, B. and Akalin, A.
Nucleic Acids Research
: gkz460.
20 June 2019
Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H., Lebedeva, S., Hirsekorn, A., Wurmus, R., Akalin, A., Mukherjee, N. and Ohler, U.
Nature Communications 10
(1): 1626.
9 April 2019
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
Karabacak Calviello, A., Hirsekorn, A., Wurmus, R., Yusuf, D. and Ohler, U.
Genome Biology 20
(1): 42.
21 February 2019
Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N., Wessels, H.H., Lebedeva, S., Sajek, M., Ghanbari, M., Garzia, A., Munteanu, A., Yusuf, D., Farazi, T., Hoell, J.I., Akat, K.M., Akalin, A., Tuschl, T. and Ohler, U.
Nucleic Acids Research 47
(2): 570-581.
25 January 2019
Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
James, A.R., Schroeder, M.P., Neumann, M., Bastian, L., Eckert, C., Gökbuget, N., Tanchez, J.O., Schlee, C., Isaakidis, K., Schwartz, S., Burmeister, T., von Stackelberg, A., Rieger, M.A., Göllner, S., Horstman, M., Schrappe, M., Kirschner-Schwabe, R., Brüggemann, M., Müller-Tidow, C., Serve, H., Akalin, A. and Baldus, C.D.
Journal of Hematology & Oncology 12
(1): 8.
14 January 2019
The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37
(24): e98658.
14 December 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E., Menegatti, J., Franke, V., Kocks, C., Boltengagen, A., Hennig, T., Theil, K., Rutkowski, A., Ferrai, C., Baer, L., Kermas, L., Friedel, C., Rajewsky, N., Akalin, A., Dölken, L., Grässer, F. and Landthaler, M.
Genome Biology 18
(1): 209.
31 October 2017
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
Grüning, B.A., Fallmann, J., Yusuf, D., Will, S., Erxleben, A., Eggenhofer, F., Houwaart, T., Batut, B., Videm, P., Bagnacani, A., Wolfien, M., Lott, S.C., Hoogstrate, Y., Hess, W.R., Wolkenhauer, O., Hoffmann, S., Akalin, A., Ohler, U., Stadler, P.F. and Backofen, R.
Nucleic Acids Research 45
(W1): W560-W566.
3 July 2017
RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Uyar, B., Yusuf, D., Wurmus, R., Rajewsky, N., Ohler, U. and Akalin, A.
Nucleic Acids Research 45
(10): e91.
2 June 2017
Altmüller, Janine (BIMSB/BIH)
Circulating tumor DNA sequencing for biologic classification and individualized risk stratification in patients with Hodgkin Lymphoma.
Heger, J.M., Mammadova, L., Mattlener, J., Sobesky, S., Cirillo, M., Altmüller, J., Kirst, E., Reinke, S., Klapper, W., Bröckelmann, P.J., Ferdinandus, J., Kaul, H., Schneider, G., Schneider, J., Schleifenbaum, J.K., Ullrich, R.T., Freihammer, M., Awerkiew, S., Lohmann, M., Klein, F., Nürnberg, P., Hallek, M., Rossi, D., Mauz-Körholz, C., Gattenlöhner, S., Bräuninger, A., Borchmann, P., von Tresckow, B. and Borchmann, S.
Journal of Clinical Oncology 42
(35): 4218-4230.
10 December 2024
Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Ihlow, J., Penter, L., Vuong, L.G., Bischoff, P., Obermayer, B., Trinks, A., Blau, O., Behnke, A., Conrad, T., Morkel, M., Wu, C.J., Westermann, J., Bullinger, L., von Brünneck, A.C., Blüthgen, N., Horst, D. and Praktiknjo, S.D.
Med
6 December 2024
(In Press)
Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture.
Patsalos, A., Halasz, L., Oleksak, D., Wei, X., Nagy, G., Tzerpos, P., Conrad, T., Hammers, D.W., Sweeney, H.L. and Nagy, L.
Journal of Clinical Investigation 134
(20): e173858.
15 October 2024
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B., Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T., Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D., Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology
28 September 2024
(In Press)
Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135
(6): 671-684.
30 August 2024
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E., Lauber, C., Manukyan, A., Deter, A., Quedenau, C., Teixeira Alves, L.G., Wylezich, C., Borodina, T., Seitz, S., Altmüller, J. and Landthaler, M.
Environment International 190
: 108875.
August 2024
XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
Chatzinikolaou, G., Stratigi, K., Siametis, A., Goulielmaki, E., Akalestou-Clocher, A., Tsamardinos, I., Topalis, P., Austin, C., Bouwman, B.A.M., Crosetto, N., Altmüller, J. and Garinis, G.A.
Science Advances 9
(45): eadi2095.
10 November 2023
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
Nikopoulou, C., Kleinenkuhnen, N., Parekh, S., Sandoval, T., Ziegenhain, C., Schneider, F., Giavalisco, P., Donahue, K.F., Vesting, A.J., Kirchner, M., Bozukova, M., Vossen, C., Altmüller, J., Wunderlich, T., Sandberg, R., Kondylis, V., Tresch, A. and Tessarz, P.
Nature Aging 3
(11): 1430-1445.
November 2023
Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.
Tschernoster, N., Erger, F., Kohl, S., Reusch, B., Wenzel, A., Walsh, S., Thiele, H., Becker, C., Franitza, M., Bartram, M.P., Kömhoff, M., Schumacher, L., Kukat, C., Borodina, T., Quedenau, C., Nürnberg, P., Rinschen, M.M., Driller, J.H., Pedersen, B.P., Schlingmann, K.P., Hüttel, B., Bockenhauer, D., Beck, B. and Altmüller, J.
Genome Medicine 15
(1): 62.
23 August 2023
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Jiang, Q., Stachelscheid, J., Bloehdorn, J., Pacholewska, A., Aszyk, C.M., Grotenhuijs, F., Müller, T.A., Onder, O., Wagle, P., Herling, C.D., Kleppe, M., Wang, Z., Coombes, K.R., Robrecht, S., Dalvi, P.S., Plosnita, B., Mayer, P., Abruzzo, L.V., Altmüller, J., Gathof, B.S., Persigehl, T., Fischer, K., Jebaraj, B.M.C., Rienhoff, H.Y., Ecker, R.C., Zhao, Y., Bruns, C.J., Stilgenbauer, S., Elenitoba-Johnson, K.S.J., Hallek, M., Schweiger, M.R., Odenthal, M., Vasyutina, E. and Herling, M.
Blood 142
(1): 44-61.
6 July 2023
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133
(13): e164637.
3 July 2023
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C., Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S., Tajbakhsh, S., Höpken, U.E. and Stricker, S.
Immunity 56
(6): 1204-1219.
13 June 2023
Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14
(1): 3025.
25 May 2023
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55
(5): 880-890.
May 2023
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera, J.A., Leu, C., Macnee, M., Khoury, J., Hoffmann, L., Coras, R., Kobow, K., Bhattarai, N., Pérez-Palma, E., Hamer, H., Brandner, S., Rössler, K., Bien, C.G., Kalbhenn, T., Pieper, T., Hartlieb, T., Butler, E., Genovese, G., Becker, K., Altmüller, J., Niestroj, L.M., Ferguson, L., Busch, R.M., Nürnberg, P., Najm, I., Blümcke, I. and Lal, D.
Brain 146
(4): 1342-1356.
April 2023
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes, R., Pascual-Reguant, A., Koehler, R., Liebeskind, J., Liebheit, A., Bauherr, S., Philipsen, L., Dittmayer, C., Laue, M., von Manitius, R., Elezkurtaj, S., Durek, P., Heinrich, F., Heinz, G.A., Guerra, G.M., Obermayer, B., Meinhardt, J., Ihlow, J., Radke, J., Heppner, F.L., Enghard, P., Stockmann, H., Aschman, T., Schneider, J., Corman, V.M., Sander, L.E., Mashreghi, M.F., Conrad, T., Hocke, A.C., Niesner, R.A., Radbruch, H. and Hauser, A.E.
Nature Communications 14
(1): 791.
11 February 2023
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
Keil, P., Wulf, A., Kachariya, N., Reuscher, S., Hühn, K., Silbern, I., Altmüller, J., Keller, M., Stehle, R., Zarnack, K., Sattler, M., Urlaub, H. and Sträßer, K.
Nucleic Acids Research 51
(2): 831-851.
25 January 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27
(43): 2101089.
27 October 2022
Mutations in TAF8 cause a neurodegenerative disorder.
Wong, K.M., Jepsen, W.M., Efthymiou, S., Salpietro, V., Sanchez-Castillo, M., Yip, J., Kriouile, Y., Diegmann, S., Dreha-Kulaczewski, S., Altmüller, J., Thiele, H., Nürnberg, P., Toosi, M.B., Akhondian, J., Ghayoor Karimiani, E., Hummel-Abmeier, H., Huppke, B., Houlden, H., Gärtner, J., Maroofian, R. and Huppke, P.
Brain 145
(9): 3022-3034.
September 2022
Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T., Himmerkus, N., Meoli, L., Fromm, A., Sewerin, S., Kriuchkova, N., Nagel, O., Ladilov, Y., Krug, S., Quintanova, C., Stumpp, M., Garbe-Schönberg, D., Westernströer, U., Merkel, C., Brinkhus, M., Altmüller, J., Schweiger, M., Mueller, D., Mutig, K., Morawski, M., Halbritter, J., Milatz, S., Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33
(4): 699-717.
April 2022
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74
(6): 1039-1046.
15 March 2022
A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.
Patsalos, A., Halasz, L., Medina-Serpas, M.A., Berger, W.K., Daniel, B., Tzerpos, P., Kiss, M., Nagy, G., Fischer, C., Simandi, Z., Varga, T. and Nagy, L.
Journal of Experimental Medicine 219
(1): e20210420.
3 January 2022
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Rosswog, C., Bartenhagen, C., Welte, A., Kahlert, Y., Hemstedt, N., Lorenz, W., Cartolano, M., Ackermann, S., Perner, S., Vogel, W., Altmüller, J., Nürnberg, P., Hertwig, F., Göhring, G., Lilienweiss, E., Stütz, A.M., Korbel, J.O., Thomas, R.K., Peifer, M. and Fischer, M.
Nature Genetics 53
(12): 1673–1685.
December 2021
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., Raabe, J., Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., Monin, M.B., Hoffmeister, C., Schlabe, S., De Domenico, E., Reusch, N., Händler, K., Reynolds, G., Blüthgen, N., Hack, G., Finnemann, C., Nischalke, H.D., Strassburg, C.P., Stephenson, E., Su, Y., Gardner, L., Yuan, D., Chen, D., Goldman, J., Rosenstiel, P., Schmidt, S.V., Latz, E., Hrusovsky, K., Ball, A.J., Johnson, J.M., Koenig, P.A., Schmidt, F.I., Haniffa, M., Heath, J.R., Kümmerer, B.M., Keitel, V., Jensen, B., Stubbemann, P., Kurth, F., Sander, L.E., Sawitzki, B., Aschenbrenner, A.C., Schultze, J.L. and Nattermann, J.
Immunity 54
(11): 2650-2669.
9 November 2021
A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover.
Boileau, E., Altmüller, J., Naarmann-de Vries, I.S. and Dieterich, C.
Briefings in Bioinformatics 22
(6): bbab219.
November 2021
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner, J., Suwalski, P., Holtgrewe, M., Rakitko, A., Thibeault, C., Müller, M., Patriki, D., Quedenau, C., Krüger, U., Ilinsky, V., Popov, I., Balnis, J., Jaitovich, A., Helbig, E.T., Lippert, L.J., Stubbemann, P., Real, L.M., Macías, J., Pineda, J.A., Fernandez-Fuertes, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Salvo, M., Blueher, A., Siemann, S., Jurisic, S., Beer, J.H., Rutishauser, J., Wiggli, B., Schmid, H., Danninger, K., Binder, R., Corman, V.M., Mühlemann, B., Arjun Arkal, R., Fragiadakis, G.K., Mick, E., Calfee, C.S., Erle, D.J., Hendrickson, C.M., Kangelaris, K.N., Krummel, M.F., Woodruff, P.G., Langelier, C.R., Venkataramani, U., García, F., Zyla, J., Drosten, C., Braun, A., Jones, T.C., Suttorp, N., Witzenrath, M., Hippenstiel, S., Zemojtel, T., Skurk, C., Wolfgang, P., Borodina, T., Ripke, S., Sander, L.E., Beule, D., Landmesser, U., Guettouche, T., Kurth, F. and Heidecker, B.
EClinicalMedicine 40
: 101099.
October 2021
Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S., Schultze, H., Shastry, K.L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N.A., Ktena, S., Tran, F., Bitzer, M., Ossowski, S., Casadei, N., Herr, C., Petersheim, D., Behrends, U., Kern, F., Fehlmann, T., Schommers, P., Lehmann, C., Augustin, M., Rybniker, J., Altmüller, J., Mishra, N., Bernardes, J.P., Krämer, B., Bonaguro, L., Schulte-Schrepping, J., De Domenico, E., Siever, C., Kraut, M., Desai, M., Monnet, B., Saridaki, M., Siegel, C.M., Drews, A., Nuesch-Germano, M., Theis, H., Heyckendorf, J., Schreiber, S., Kim-Hellmuth, S., Nattermann, J., Skowasch, D., Kurth, I., Keller, A., Bals, R., Nürnberg, P., Rieß, O., Rosenstiel, P., Netea, M.G., Theis, F., Mukherjee, S., Backes, M., Aschenbrenner, A.C., Ulas, T., Breteler, M.M.B., Giamarellos-Bourboulis, E.J., Kox, M., Becker, M., Cheran, S., Woodacre, M.S., Goh, E.L. and Schultze, J.L.
Nature 594
(7862): 265-270.
10 June 2021
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K., Fogo, M.S., Pinto, B.G.G., Alves, A.Y., Suzuki, A.M., Morales, A.G., Ezquina, S., Sosa, O.J., Sutton, G.J., Sunaga-Franze, D.Y., Bueno, A.P., Seabra, G., Sardinha, L., Costa, S.S., Rosenberg, C., Zachi, E.C., Sertie, A.L., Martins-de-Souza, D., Reis, E.M., Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26
(5): 1589-1605.
May 2021
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., Baßler, K., Saridaki, M., Knoll, R., Pecht, T., Kapellos, T.S., Doulou, S., Kröger, C., Herbert, M., Holsten, L., Horne, A., Gemünd, I.D., Rovina, N., Agrawal, S., Dahm, K., van Uelft, M., Drews, A., Lenkeit, L., Bruse, N., Gerretsen, J., Gierlich, J., Becker, M., Händler, K., Kraut, M., Theis, H., Mengiste, S., Domenico, E., Schulte-Schrepping, J., Seep, L., Raabe, J., Hoffmeister, C., ToVinh, M., Keitel, V., Rieke, G., Talevi, V., Skowasch, D., Aziz, N.A., Pickkers, P., van de Veerdonk, F.L., Netea, M.G., Schultze, J.L., Kox, M., Breteler, M.M.B., Nattermann, J., Koutsoukou, A., Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13
(1): 7.
13 January 2021
Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B., Alonso, G., Georgana, I., El-Jesr, M., Martín, R., Shair, K.H.Y., Fischer, C., Sauer, S., Maluquer de Motes, C. and Alcamí, A.
Science Advances 6
(38): eabb4565.
18 September 2020
Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El-Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., Lenz, C., Salinas, G., Diecke, S., Müller, C., Adham, I., Altmüller, J., Nürnberg, P., Paul, T., Zimmermann, W.H., Hasenfuss, G., Wollnik, B. and Cyganek, L.
Circulation 142
(11): 1059-1076.
15 September 2020
Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W., Shang, F., Wang, X., Fanti, A.K., Greco, A., Busch, K., Klapproth, K., Zhang, Q., Quedenau, C., Sauer, S., Feyerabend, T.B., Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27
(3): 383-395.
3 September 2020
Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E., Lafzi, A., Moutinho, C., Ziegenhain, C., McCarthy, D.J., Álvarez-Varela, A., Batlle, E., Sagar, Grün, D., Lau, J.K., Boutet, S.C., Sanada, C., Ooi, A., Jones, R.C., Kaihara, K., Brampton, C., Talaga, Y., Sasagawa, Y., Tanaka, K., Hayashi, T., Braeuning, C., Fischer, C., Sauer, S., Trefzer, T., Conrad, C., Adiconis, X., Nguyen, L.T., Regev, A., Levin, J.Z., Parekh, S., Janjic, A., Wange, L.E., Bagnoli, J.W., Enard, W., Gut, M., Sandberg, R., Nikaido, I., Gut, I., Stegle, O. and Heyn, H.
Nature Biotechnology 38
(6): 747-755.
June 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
Pivovarova-Ramich, O., Markova, M., Weber, D., Sucher, S., Hornemann, S., Rudovich, N., Raila, J., Sunaga-Franze, D., Sauer, S., Rohn, S., Pfeiffer, A.F.H. and Grune, T.
Redox Biology 29
(2): 101397.
January 2020
R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M., Del Mar Reinés, M., Müllerke, S., Fischer, C., Kapalczynska, M., Berger, H., Bakker, E.R.M., Mollenkopf, H.J., Rothenberg, M.E., Wiedenmann, B., Sauer, S. and Meyer, T.F.
Nature Cell Biology 21
(7): 812-823.
July 2019
A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
Hernáez, B., Alonso-Lobo, J.M., Montanuy, I., Fischer, C., Sauer, S., Sigal, L., Sevilla, N. and Alcamí, A.
Nature Communications 9
(1): 5440.
21 December 2018
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F., Margaritte-Jeannin, P., Barnes, K.C., Cookson, W.O.C., Altmüller, J., Ang, W., Barr, R.G., Beaty, T.H., Becker, A.B., Beilby, J., Bisgaard, H., Bjornsdottir, U.S., Bleecker, E., Bonnelykke, K., Boomsma, D.I., Bouzigon, E., Brightling, C.E., Brossard, M., Brusselle, G.G., Burchard, E., Burkart, K.M., Bush, A., Chan-Yeung, M., Chung, K.F., Couto Alves, A., Curtin, J.A., Custovic, A., Daley, D., de Jongste, J.C., Del-Rio-Navarro, B.E., Donohue, K.M., Duijts, L., Eng, C., Eriksson, J.G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M.A., Freidin, M.B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S.A, Gilliland, F., Granell, R., Graves, P.E., Gudbjartsson, D.F., Haahtela, T., Heckbert, S.R., Heederik, D., Heinrich, J., Helioevaara, M., Henderson, J., Himes, B.E., Hirose, H., Hirschhorn, J.N., Hofman, A., Holt, P., Hottenga, J., Hudson, T.J., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V.W.V., James, A., Janson, C., Jarvelin, M.R., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kähönen, M., Kantor, D.B., Karunas, A.S., Khusnutdinova, E., Koppelman, G.H., Kozyrskyj, A.L., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y.A., Lehtimaeki, T., Letort, S., Levin, A.M., Li, G., Liang, L., Loehr, L.R., London, S.J., Loth, D.W., Manichaikul, A., Marenholz, I., Martinez, F.J., Matheson, M.C., Mathias, R.A., Matsumoto, K., Mbarek, H., McArdle, W.L., Melbye, M., Melen, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A.W., Myers, R.A., Nieuwenhuis, M.A.E., Noguchi, E., O'Connor, G.T., Ogorodova, L.M., Palmer, C.D., Palotie, A., Park, J.E., Pennell, C.E., Pershagen, G., Polonikov, A., Postma, D.S., Probst-Hensch, N., Puzyrev, V.P., Raby, B.A., Raitakari, O.T., Ramasamy, A., Rich, S.S., Robertson, C.F., Romieu, I., Salam, M.T., Salomaa, V., Schluenssen, V., Scott, R., Selivanova, P.A., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L.J., Solodilova, M., Standl, M., Stefansson, K., Strachan, D.P., Stricker, B.H., Takahashi, A., Thompson, P.J., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C.M.T., Torgerson, D.G., Tsunoda, T., Uitterlinden, A.G., van der Valk, R.J.P., Vaysse, A., Vedantam, S., von Berg, A., von Mutius, E., Vonk, J.M., Waage, J., Wareham, N.J., Weiss, S.T., White, W.B., Wickman, M., Widén, E., Willemsen, G., Williams, L.K., Wouters, I.M., Yang, J.J., Zhao, J.H., Moffatt, M.F., Ober, C. and Nicolae, D.L.
Nature Genetics 50
(1): 42-53.
January 2018
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W., Feyerabend, T.B., Rössler, J., Wang, X., Postrach, D., Busch, K., Rode, I., Klapproth, K., Dietlein, N., Quedenau, C., Chen, W., Sauer, S., Wolf, S., Höfer, T. and Rodewald, H.Re.
Nature 548
(7668): 456-460.
24 August 2017
Andrade Navarro, Miguel
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I.M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M.A., Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8
: 14127.
13 February 2017
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M., Bounab, Y., Strempel, N., Klockmeier, K., Yigit, S., Friedrich, R.P., Chaurasia, G., Li, S., Hesse, F., Riechers, S.P., Russ, J., Nicoletti, C., Boeddrich, A., Wiglenda, T., Haenig, C., Schnoegl, S., Fournier, D., Graham, R.K., Hayden, M.R., Sigrist, S., Bates, G.P., Priller, J., Andrade-Navarro, M.A., Futschik, M.E. and Wanker, E.E.
Genome Research 25
(5): 701-713.
May 2015
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K., Ullrich, F., Muench, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M.A., von Kries, J.P., Stauber, T. and Jentsch, T.J.
Science 344
(6184): 634-638.
9 May 2014
Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E., Mah, N., Naumann, H., Pongrac, I.M., Cerdá-Esteban, N., Fontaine, J.F., Wang, Y., Chen, W., Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27
(17): 1932-1946.
1 September 2013
Bio++: efficient extensible libraries and tools for computational molecular evolution.
Gueguen, L., Gaillard, S., Boussau, B., Gouy, M., Groussin, M., Rochette, N.C., Bigot, T., Fournier, D., Pouyet, F., Cahais, V., Bernard, A., Scornavacca, C., Nabholz, B., Haudry, A., Dachary, L., Galtier, N., Belkhir, K. and Dutheil, J.Y.
Molecular Biology and Evolution 30
(8): 1745-1750.
August 2013
CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A., Qadri, F., Leukel, L., Yilmaz, R., Fontaine, J.F., Sihn, G., Bader, M., Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123
(3): 1343-1347.
1 March 2013
A role for GPx3 in activity of normal and leukemia stem cells.
Herault, O., Hope, K.J., Deneault, E., Mayotte, N., Chagraoui, J., Wilhelm, B.T., Cellot, S., Sauvageau, M., Andrade-Navarro, M.A., Hebert, J. and Sauvageau, G.
Journal of Experimental Medicine 209
(5): 895-901.
7 May 2012
Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula.
Frahm, S., Slimak, M.A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.F., Tsetlin, V., Maskos, U. and Ibanez-Tallon, I.
Neuron 70
(3): 522-535.
12 May 2011
Loss of fish actinotrichia proteins and the fin-to-limb transition.
Zhang, J., Wagh, P., Guay, D., Sanchez-Pulido, L., Padhi, B.K., Korzh, V., Andrade-Navarro, M.A. and Akimenko, M.A.
Nature 466
(7303): 234-237.
8 July 2010
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M., Vockentanz, L., Kharazi, S., Huska, M.R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., Nerlov, C., Leutz, A., Andrade-Navarro, M.A., Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41
(11): 1207-1215.
November 2009
Mitochondrial vesicles: an ancient process providing new links to peroxisomes.
Andrade-Navarro, M.A., Sanchez-Pulido, L. and McBride, H.M.
Current Opinion in Cell Biology 21
(4): 560-567.
August 2009
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.
Neuspiel, M., Schauss, A.C., Braschi, E., Zunino, R., Rippstein, P., Rachubinski, R.A., Andrade-Navarro, M.A. and McBride, H.M.
Current Biology 18
(2): 102-108.
22 January 2008
Systematic association of genes to phenotypes by genome and literature mining.
Korbel, J.O., Doerks, T., Jensen, L.J., Perez-Iratxeta, C., Kaczanowski, S., Hooper, S.D., Andrade, M.A. and Bork, P.
PLoS Biology 3
(5): e134.
5 April 2005
Association of genes to genetically inherited diseases using data mining.
Perez-Iratxeta, C., Bork, P. and Andrade, M.A.
Nature Genetics 31
(3): 316-319.
July 2002
XplorMed: a tool for exploring MEDLINE abstracts.
Perez-Iratxeta, C., Bork, P. and Andrade, M.A.
Trends in Biochemical Sciences 26
(9): 573-575.
1 January 2001
Heat repeats in Huntington's disease protein.
Andrade, M.A. and Bork, P.
Nature Genetics 11
(2): 115-116.
1 October 1995
Challenging times for bioinformatics.
Casari, G., Andrade, M.A., Bork, P., Daruvar, A., Ouzounis, C., Schneider, R., Tamames, J., Valencia, A. and Sander, C.
Nature 376
: 647-648.
1 January 1995
Bader, Michael
Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury.
Sanad, A.M., Qadri, F., Popova, E., Rodrigues, A.F., Heinbokel, T., Quach, S., Schulz, A., Bachmann, S., Kreutz, R., Alenina, N. and Bader, M.
Kidney International 104
(2): 293-304.
August 2023
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.
Bekassy, Z., Lopatko Fagerström, I., Bader, M. and Karpman, D.
Nature Reviews Immunology 22
(7): 411-428.
July 2022
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.
Batlle, D., Monteil, V., Garreta, E., Hassler, L., Wysocki, J., Chandar, V., Schwartz, R.E., Mirazimi, A., Montserrat, N., Bader, M. and Penninger, J.M.
Cell 185
(11): 1837-1839.
26 May 2022
Serotonin limits generation of chromaffin cells during adrenal organ development.
Kameneva, P., Melnikova, V.I., Kastriti, M.E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A.V., Kalinina, T.S., Kudryashov, N.V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P., Yakushov, V.D., Sheftel, B.I., Zikmund, T., Kaiser, J., Fried, K., Alenina, N., Voronezhskaya, E.E. and Adameyko, I.
Nature Communications 13
(1): 2901.
25 May 2022
Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Mohammed, M., Johnson, D.N., Wang, L.A., Harden, S.W., Sheng, W., Spector, E.A., Elsaafien, K., Bader, M., Steckelings, U.M., Scott, K.A., Frazier, C.J., Sumners, C., Krause, E.G. and de Kloet, A.D.
Cardiovascular Research 118
(3): 883-896.
21 February 2022
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
(6): 1653-1668.
December 2021
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Golic, M. and Kräker, K.
Diabetologia 64
(12): 2829-2842.
December 2021
The continued need for animals to advance brain research.
Homberg, J.R., Adan, R.A.H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., van Dijk, G., Eisel, U.L.M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., van Dam, A.M., Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Kasri, N.N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D.A., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., de la Prida, L.M., Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L.J.M.J., Takeuchi, T., van der Veen, R., Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., van der Zee, E.A. and Genzel, L.
Neuron 109
(15): 2374-2379.
4 August 2021
Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens, B., Schulze, A., Wysocki, J., Lin, M.H., Ye, M., Kanwar, Y.S., Bader, M., Velez, J.C.Q., Miner, J.H. and Batlle, D.
Kidney International 99
(4): 900-913.
April 2021
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13
(1): 713-727.
February 2021
Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection.
Melo, E.M., Del Sarto, J., Vago, J.P., Tavares, L.P., Rago, F., Gonçalves, A.P.F., Machado, M.G., Aranda-Pardos, I., Valiate, B.V.S., Cassali, G.D., Pinho, V., Sousa, L.P., A-Gonzalez, N., Campagnole-Santos, M.J., Bader, M., Santos, R.A.S., Machado, A.V., Ludwig, S. and Teixeira, M.M.
Pharmacological Research 163
: 105292.
January 2021
Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L., Panayotis, N., Alber, S., Dagan, S.Y., Okladnikov, N., Koppel, I., Di Pizio, A., Song, D.A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M. and Fainzilber, M.
Science 369
(6505): 842-846.
14 August 2020
The dual role of serotonin in colorectal cancer.
Kannen, V., Bader, M., Sakita, J.Y., Uyemura, S.A. and Squire, J.A.
Trends in Endocrinology and Metabolism 31
(8): 611-625.
August 2020
Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M., Ferreira, D.G., Batalha, V.L., Marques-Morgado, I., Coelho, J.E., Pereira, P., Gomes, R., Pinto, A., Carvalho, S., Canas, P.M., Cuvelier, L., Buée-Scherrer, V., Faivre, E., Baqi, Y., Müller, C.E., Pimentel, J., Schiffmann, S.N., Buée, L., Bader, M., Outeiro, T.F., Blum, D., Cunha, R.A., Marie, H., Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25
(8): 1876-1900.
August 2020
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
The (pro)renin receptor: what's in a name?
Simons, M., Bader, M. and Müller, D.N.
Nature Reviews Nephrology 16
(5): 304.
May 2020
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11
(1): 103-119.
February 2020
Inhibition of serotonin synthesis: a novel therapeutic paradigm.
Bader, M.
Pharmacology & Therapeutics 205
: 107423.
January 2020
Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent.
Serfozo, P., Wysocki, J., Gulua, G., Schulze, A., Ye, M., Liu, P., Jin, J., Bader, M., Myöhänen, T., García-Horsman, J.A. and Batlle, D.
Hypertension 75
(1): 173-182.
January 2020
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly, L.A., Thompson, R.E., Zhao, S., Lepack, A.E., Lyu, Y., Bhanu, N.V., Zhang, B., Loh, Y.H.E., Ramakrishnan, A., Vadodaria, K.C., Heard, K.J., Erikson, G., Nakadai, T., Bastle, R.M., Lukasak, B.J., Zebroski, H., Alenina, N., Bader, M., Berton, O., Roeder, R.G., Molina, H., Gage, F.H., Shen, L., Garcia, B.A., Li, H., Muir, T.W. and Maze, I.
Nature 567
(7749): 535-539.
28 March 2019
Peripheral serotonin synthesis as a new drug target.
Matthes, S. and Bader, M.
Trends in Pharmacological Sciences 39
(6): 560-572.
June 2018
Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135
(4): 551.
April 2018
The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7).
Santos, R.A.S., Sampaio, W.O., Alzamora, A.C., Motta-Santos, D., Alenina, N., Bader, M. and Campagnole-Santos, M.J.
Physiological Reviews 98
(1): 505-553.
January 2018
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J., Novitzky-Basso, I., Thiriot, A., Casanova-Acebes, M., Bianchini, M., Etheridge, S.L., Hub, E., Nitz, K., Artinger, K., Eller, K., Caamano, J., Ruelicke, T., Moss, P., Megens, R.T.A., von Andrian, U.H., Hidalgo, A., Weber, C. and Rot, A.
Nature Immunology 18
(7): 753-761.
July 2017
The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
Silva, C.R., Oliveira, S.M., Hoffmeister, C., Funck, V., Guerra, G.P., Trevisan, G., Tonello, R., Rossato, M.F., Pesquero, J.B., Bader, M., Oliveira, M.S., McDougall, J.J. and Ferreira, J.
Annals of the Rheumatic Diseases 75
(1): 260-268.
January 2016
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47
(6): 647-653.
June 2015
Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.
Cui, Y., Niziolek, P.J., MacDonald, B.T., Alenina, N., Matthes, S., Jacobsen, C.M., Conlon, R.A., Brommage, R., Powell, D.R., He, X., Bader, M., Williams, B.O., Warman, M.L. and Robling, A.G.
Nature Medicine 20
(11): 1229-1230.
6 November 2014
Mas and its related G protein-coupled receptors, Mrgprs.
Bader, M., Alenina, N., Andrade-Navarro, M.A. and Santos, R.A.
Pharmacological Reviews 66
(4): 1080-1105.
October 2014
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J., Kassmann, M., Szijártó, I.A., Hercule, H.C., Tano, J.Y., Weinert, S., Heidenreich, M., Pathan, A.R., Anistan, Y.M., Alenina, N., Rusch, N.J., Bader, M., Jentsch, T.J. and Gollasch, M.
Circulation Research 115
(2): 263-272.
7 July 2014
Discovery and characterization of alamandine, a novel component of the renin-angiotensin system.
Lautner, R.Q., Villela, D.C., Fraga-Silva, R.A., Silva, N.C., Verano-Braga, T., Costa-Fraga, F., Jankowski, J., Jankowski, V., De Sousa, F.B., Alzamora, A.C., Soares, E.R., Barbosa, C.M., Kjeldsen, F., Oliveira, A.C., Braga, J.F., Savergnini, S.Q., Etelvino, G.M., Bastos Peluso, A.A., Passos-Silva, D.G., Ferreira, A.J., Alves, F., Martins, A.S., Raizada, M.K., Paula, R.D., Motta-Santos, D., Klempin, F., Pimenta, A.M.C., Alenina, N., Sinisterra, R.D.M., Bader, M., Campagnole-Santos, M.J. and Santos, R.A.S.
Circulation Research 112
(8): 1104-1111.
12 April 2013
CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A., Qadri, F., Leukel, L., Yilmaz, R., Fontaine, J.F., Sihn, G., Bader, M., Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123
(3): 1343-1347.
1 March 2013
Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease.
Kränkel, N., Kuschnerus, K., Müller, M., Speer, T., Mocharla, P., Madeddu, P., Bader, M., Lüscher, T.F. and Landmesser, U.
Circulation 127
(5): 594-603.
5 February 2013
Lrp5 functions in bone to regulate bone mass.
Cui, Y., Niziolek, P.J., Macdonald, B.T., Zylstra, C.R., Alenina, N., Robinson, D.R., Zhong, Z., Matthes, S., Jacobsen, C.M., Conlon, R.A., Brommage, R., Liu, Q., Mseeh, F., Powell, D.R., Yang, Q.M., Zambrowicz, B., Gerrits, H., Gossen, J.A., He, X., Bader, M., Williams, B.O., Warman, M.L. and Robling, A.G.
Nature Medicine 17
(6): 684-691.
June 2011
Platelet-derived serotonin links vascular disease and tissue fibrosis.
Dees, C., Akhmetshina, A., Zerr, P., Reich, N., Palumbo, K., Horn, A., Juengel, A., Beyer, C., Kroenke, G., Zwerina, J., Reiter, R., Alenina, N., Maroteaux, L., Gay, S., Schett, G., Distler, O. and Distler, J.H.
Journal of Experimental Medicine 208
(5): 961-972.
9 May 2011
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.
Bader, M.
Annual Review of Pharmacology and Toxicology 50
: 439-65.
2010
Central control of fever and female body temperature by RANKL/RANK.
Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., Klaere, S., Komnenovic, V., Mimata, H., Yoshimatsu, H., Takahashi, N., von Haeseler, A., Bader, M., Kilic, S.S., Ueta, Y., Pifl, C., Narumiya, S. and Penninger, J.M.
Nature 462
(7272): 505-509.
26 November 2009
Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Paulmann, N., Grohmann, M., Voigt, J.P., Bert, B., Vowinckel, J., Bader, M., Skelin, M., Jevsek, M., Fink, H., Rupnik, M. and Walther, D.J.
PLoS Biology 7
(10): e1000229.
27 October 2009
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M., Steinman, L., Aktas, O. and Zipp, F.
Nature Medicine 15
(7): 788-793.
July 2009
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119
(22): 2904-2912.
9 June 2009
Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Xi, L., Das, A., Zhao, Z.Q., Merino, V.F., Bader, M. and Kukreja, R.C.
Circulation 118
(14 Suppl): S32-S37.
30 September 2008
Aggravation of viral hepatitis by platelet-derived serotonin.
Lang, P.A., Contaldo, C., Georgiev, P., El-Badry, A.M., Recher, M., Kurrer, M., Cervantes-Barragan, L., Ludewig, B., Calzascia, T., Bolinger, B., Merkler, D., Odermatt, B., Bader, M., Graf, R., Clavien, P.A., Hegazy, A.N., Loehning, M., Harris, N.L., Ohashi, P.S., Hengartner, H., Zinkernagel, R.M. and Lang, K.S.
Nature Medicine 14
(7): 756-761.
July 2008
Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
Dempsie, Y., Morecroft, I., Welsh, D.J., Macritchie, N.A., Herold, N., Loughlin, L., Nilsen, M., Peacock, A.J., Harmar, A., Bader, M. and Maclean, M.R.
Circulation 2008
(117): 2928-2937.
3 June 2008
Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
Gratze, P., Dechend, R., Stocker, C., Park, J.K., Feldt, S., Shagdarsuren, E., Wellner, M., Gueler, F., Rong, S., Gross, V., Obst, M., Plehm, R., Alenina, N., Zenclussen, A., Titze, J., Small, K., Yokota, Y., Zenke, M., Luft, F.C. and Mueller, D.N.
Circulation 117
(20): 2645-2656.
20 May 2008
Normal brain development in importin-alpha5 deficient-mice.
Shmidt, T., Hampich, F., Ridders, M., Schultrich, S., Hans, V.H., Tenner, K., Vilianovich, L., Qadri, F., Alenina, N., Hartmann, E., Koehler, M. and Bader, M.
Nature Cell Biology 9
(12): 1337-1338.
December 2007
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Nocito, A., Dahm, F., Jochum, W., Jang, J.H., Georgiev, P., Bader, M., Renner, E.L. and Clavien, P.A.
Gastroenterology 133
(2): 608-618.
August 2007
Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice.
Nocito, A., Georgiev, P., Dahm, F., Jochum, W., Bader, M., Graf, R. and Clavien, P.A.
Hepatology 45
(2): 369-376.
February 2007
Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease.
Walther, T., Tschoepe, C., Sterner-Kock, A., Westermann, D., Heringer-Walther, S., Riad, A., Nikolic, A., Wang, Y., Ebermann, L., Siems, W.E., Bader, M., Shakibaei, M., Schultheiss, H.P. and Doerner, A.
Circulation 115
(3): 333-344.
23 January 2007
Platelet-derived serotonin mediates liver regeneration.
Lesurtel, M., Graf, R., Aleil, B., Walther, D.J., Tian, Y., Jochum, W., Gachet, C., Bader, M. and Clavien, P.A.
Science 312
(5770): 104-107.
7 April 2006
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Donath, S., Li, P., Willenbockel, C., Al-Saadi, N., Gross, V., Willnow, T.E., Bader, M., Martin, U., Bauersachs, J., Wollert, K.C., Dietz, R. and von Harsdorf, R.
Circulation 113
(9): 1203-1212.
7 March 2006
Serotonin regulates mammary gland development via an autocrine-paracrine loop.
Matsuda, M., Imaoka, T., Vomachka, A.J., Gudelsky, G.A., Hou, Z.Y., Mistry, M., Bailey, J.P., Nieport, K.M., Walther, D.J., Bader, M. and Horseman, N.D.
Developmental Cell 6
(2): 193-203.
1 January 2004
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Santos, R.A.S., e Silva, A.C.S., Maric, C., Silva, D.M.R., Machado, R.P., de Buhr, I., Heringer-Walther, S., Pinheiro, S.V.B., Lopes, M.T., Bader, M., Mendes, E.P., Lemos, V.S., Campagnole-Santos, M.J., Schultheiss, H.P., Speth, R. and Walther, T.
Proceedings of the National Academy of Sciences of the United States of America 100
(14): 8258-8263.
8 July 2003
Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Walther, D.J., Peter, J.U., Bashammakh, S., Hoertnagl, H., Voits, M., Fink, H. and Bader, M.
Science 299
(5603): 76-76.
3 January 2003
Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release.
Walther, D.J., Peter, J.U., Winter, S., Hoeltje, M., Paulmann, N., Grohmann, M., Vowinckel, J., Alamo-Bethencourt, V., Wilhelm, C.S., Ahnert-Hilger, G. and Bader, M.
Cell 115
(7): 851-862.
1 January 2003
In vivo bradykinin B2 receptor activation reduces renal fibrosis.
Schanstra, J.P., Neau, E., Drogoz, P., Gomez, M.A.A., Novoa, J.M.L., Calise, D., Pecher, C., Bader, M., Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 110
(3): 371-379.
1 August 2002
Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning.
Faendrich, F., Lin, X., Chai, G.X., Schulze, M., Ganten, D., Bader, M., Holle, J., Huang, D.S., Parwaresch, R., Zavazava, N. and Binas, B.
Nature Medicine 8
: 171-178.
1 February 2002
Targeting kinin B1 receptor for therapeutic neovascularization.
Emanueli, C., Salis, M.B., Stacca, T., Pintus, G., Kirchmair, R., Isner, J.M., Pinna, A., Gaspa, L., Regoli, D., Cayla, C., Pesquero, J.B., Bader, M. and Madeddu, P.
Circulation 105
: 360-366.
22 January 2002
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.
Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C.M., Calixto, J.B., Lewin, G.R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 8140-8145.
5 July 2000
Smooth-muscle contraction without smooth-muscle myosin.
Morano, I., Chai, G.X., Baltas, L.G., Lamounier-Zepter, V., Lutsch, G., Kott, M., Haase, H. and Bader, M.
Nature Cell Biology 2
(6): 371-375.
1 June 2000
Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.
Binas, B., Danneberg, H., McWhir, J., Mullins, L. and Clark, A.J.
FASEB Journal 13
(8): 805-812.
May 1999
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.
Schinke, M., Baltatu, O., Boehm, M., Peters, J., Rascher, W., Bricca, G., Lippoldt, A., Ganten, D. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 3975-3980.
30 March 1999
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3.
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I. and Willnow, T.E.
Cell 96
(4): 507-515.
19 February 1999
Bargou, Ralf C.
Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S., Gries, M., Janz, M., Bargou, R., Doerken, B. and Mapara, M.Y.
Blood 101
(9): 3568-3573.
1 May 2003
Behlke, Joachim
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13461-13466.
7 September 2005
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P., Kuemmel, D., Prinz, B., Holz, C., Schultchen, J., Lang, C., Niesen, F.H., Hofmann, K.P., Delbrueck, H., Behlke, J., Mueller, E.C., Jarosch, E., Sommer, T. and Heinemann, U.
EMBO Journal 24
(5): 875-884.
1 January 2005
Bergmann, Martin W.
Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Freund, C., Schmidt-Ullrich, R., Baurand, A., Dunger, S., Schneider, W., Loser, P., El-Jamali, A., Dietz, R., Scheidereit, C. and Bergmann, M.W.
Circulation 111
(18): 2319-2325.
1 January 2005
In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Mehrhof, F.B., Mueller, F.U., Bergmann, M.W., Li, P.F., Wang, Y.B., Schmitz, W., Dietz, R. and von Harsdorf, R.
Circulation 104
: 2088-2094.
1 January 2001
Besser, Daniel
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F.H., Stein, U., Fichtner, I., Schlag, P.M. and Birchmeier, W.
Gastroenterology 137
(11): 165-175.
July 2009
Beule, Dieter (MDC/BIH)
Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Ihlow, J., Penter, L., Vuong, L.G., Bischoff, P., Obermayer, B., Trinks, A., Blau, O., Behnke, A., Conrad, T., Morkel, M., Wu, C.J., Westermann, J., Bullinger, L., von Brünneck, A.C., Blüthgen, N., Horst, D. and Praktiknjo, S.D.
Med
6 December 2024
(In Press)
Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova, D., Fritsch, V.N., Siebert, K., Methling, K., Lalk, M., Busche, T., Kalinowski, J., Weiner, J., Beule, D., Bertrams, W., Kohler, T.P., Hammerschmidt, S., Löwa, A., Fischer, M., Mieth, M., Hellwig, K., Frey, D., Neudecker, J., Rueckert, J.C., Toennies, M., Bauer, T.T., Graff, M., Tran, H.L., Eggeling, S., Gruber, A.D., Antelmann, H., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 64
(6): 2301983.
December 2024
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B., Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T., Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D., Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology
28 September 2024
(In Press)
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
REEV: review, evaluate and explain variants.
Hramyka, D., Sczakiel, H.L., Zhao, M.X., Stolpe, O., Nieminen, M., Adam, R., Danyel, M., Einicke, L., Hägerling, R., Knaus, A., Mundlos, S., Schwartzmann, S., Seelow, D., Ehmke, N., Mensah, M.A., Boschann, F., Beule, D. and Holtgrewe, M.
Nucleic Acids Research 52
(W1): W148-W158.
5 July 2024
Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D., Knapstein, P.R., Otto, E., Köhli, P., Sevecke, J., Graef, F., Graffmann, C., Fuchs, M., Jiang, S., Rickert, M., Erdmann, C., Appelt, J., Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G., Xie, W., Donat, A., Schinke, T., Ivanov, A., Tchouto, M.N., Beule, D., Frosch, K.H., Baranowsky, A., Tsitsilonis, S. and Keller, J.
Science Translational Medicine 16
(743): eadk9129.
17 April 2024
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15
(1): 2788.
30 March 2024
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
Leveraging large language models for decision support in personalized oncology.
Benary, M., Wang, X.D., Schmidt, M., Soll, D., Hilfenhaus, G., Nassir, M., Sigler, C., Knödler, M., Keller, U., Beule, D., Keilholz, U., Leser, U. and Rieke, D.T.
JAMA Network Open 6
(11): e2343689.
November 2023
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37
(11): 2237-2249.
November 2023
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E., Planas-Fèlix, M., Burkert, M., Puiggròs, M., Toedling, J., Thiessen, N., Blanc, E., Szymansky, A., Hertwig, F., Ishaque, N., Beule, D., Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F., Haase, K., Schulte, J.H. and Henssen, A.G.
Cell Genomics 3
(10): 100402.
11 October 2023
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A.L., Tchenio, A., Benson, S., Vendrell, M., D'Alessandro, A., Beule, D., Pellerin, L., Mameli, M. and Paolicelli, R.C.
Nature Communications 14
(1): 5749.
16 September 2023
SODAR: managing multiomics study data and metadata.
Nieminen, M., Stolpe, O., Kuhring, M., Weiner, J., Pett, P., Beule, D. and Holtgrewe, M.
GigaScience 12
: giad052.
27 July 2023
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes, R., Pascual-Reguant, A., Koehler, R., Liebeskind, J., Liebheit, A., Bauherr, S., Philipsen, L., Dittmayer, C., Laue, M., von Manitius, R., Elezkurtaj, S., Durek, P., Heinrich, F., Heinz, G.A., Guerra, G.M., Obermayer, B., Meinhardt, J., Ihlow, J., Radke, J., Heppner, F.L., Enghard, P., Stockmann, H., Aschman, T., Schneider, J., Corman, V.M., Sander, L.E., Mashreghi, M.F., Conrad, T., Hocke, A.C., Niesner, R.A., Radbruch, H. and Hauser, A.E.
Nature Communications 14
(1): 791.
11 February 2023
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60
(6): 2102725.
1 December 2022
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
Non-redundant functions of group 2 innate lymphoid cells.
Jarick, K.J., Topczewska, P.M., Jakob, M.O., Yano, H., Arifuzzaman, M., Gao, X., Boulekou, S., Stokic-Trtica, V., Leclère, P.S., Preußer, A., Rompe, Z.A., Stamm, A., Tsou, A.M., Chu, C., Heinrich, F.R., Guerra, G.M., Durek, P., Ivanov, A., Beule, D., Helfrich, S., Duerr, C.U., Kühl, A.A., Stehle, C., Romagnani, C., Mashreghi, M.F., Diefenbach, A., Artis, D. and Klose, C.S.N.
Nature 611
(7937): 794-800.
24 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A., Bunse, M., Joedicke, J.J., Blanc, E., Gudipati, V., Moles, M.W., Shiku, H., Beule, D., Huppa, J.B., Höpken, U.E. and Rehm, A.
Molecular Therapy 30
(11): 3358-3378.
2 November 2022
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum, R., Suwalski, P., Asgharian, H., Du Zhipei, G., Lin, H., Weiner, J., Holtgrewe, M., Thibeault, C., Müller, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Blüher, A., Siemann, S., Telman, D., Suttorp, N., Witzenrath, M., Hippenstiel, S., Skurk, C., Poller, W., Sander, L.E., Beule, D., Kurth, F., Guettouche, T., Landmesser, U., Berka, J., Luong, K., Rubelt, F. and Heidecker, B.
EClinicalMedicine 48
: 101438.
June 2022
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M., von Arx, A.S., Cruz-Ochoa, N., Dawson, K., Ivanov, A., Mueller, F.S., Lin, H.Y., Amport, R., Mildenberger, W., Mattei, D., Beule, D., Földy, C., Greter, M., Notter, T. and Meyer, U.
Science Advances 8
(9): eabi6672.
4 March 2022
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D., Wyler, E., Landthaler, M., Obermayer, B., von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185
(3): 493-512.
3 February 2022
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F., Bischoff, P., Peidli, S., Sieber, A., Trinks, A., Lüthen, M., Obermayer, B., Blanc, E., Ruchiy, Y., Sell, T., Mamlouk, S., Arsie, R., Wei, T.T., Klotz-Noack, K., Schwarz, R.F., Sawitzki, B., Kamphues, C., Beule, D., Landthaler, M., Sers, C., Horst, D., Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13
(10): e14123.
7 October 2021
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner, J., Suwalski, P., Holtgrewe, M., Rakitko, A., Thibeault, C., Müller, M., Patriki, D., Quedenau, C., Krüger, U., Ilinsky, V., Popov, I., Balnis, J., Jaitovich, A., Helbig, E.T., Lippert, L.J., Stubbemann, P., Real, L.M., Macías, J., Pineda, J.A., Fernandez-Fuertes, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Salvo, M., Blueher, A., Siemann, S., Jurisic, S., Beer, J.H., Rutishauser, J., Wiggli, B., Schmid, H., Danninger, K., Binder, R., Corman, V.M., Mühlemann, B., Arjun Arkal, R., Fragiadakis, G.K., Mick, E., Calfee, C.S., Erle, D.J., Hendrickson, C.M., Kangelaris, K.N., Krummel, M.F., Woodruff, P.G., Langelier, C.R., Venkataramani, U., García, F., Zyla, J., Drosten, C., Braun, A., Jones, T.C., Suttorp, N., Witzenrath, M., Hippenstiel, S., Zemojtel, T., Skurk, C., Wolfgang, P., Borodina, T., Ripke, S., Sander, L.E., Beule, D., Landmesser, U., Guettouche, T., Kurth, F. and Heidecker, B.
EClinicalMedicine 40
: 101099.
October 2021
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G., Wyler, E., Pennitz, P., Postmus, D., Vladimirova, D., Kazmierski, J., Pott, F., Dietert, K., Muelleder, M., Farztdinov, V., Obermayer, B., Wienhold, S.M., Andreotti, S., Hoefler, T., Sawitzki, B., Drosten, C., Sander, L.E., Suttorp, N., Ralser, M., Beule, D., Gruber, A.D., Goffinet, C., Landthaler, M., Trimpert, J. and Witzenrath, M.
Nature Communications 12
(1): 4869.
11 August 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W.
Cancer Research 81
(8): 2116-2127.
April 2021
Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L., Krupp, F., Harnett, D., Turko, P., Ambrozkiewicz, M.C., Sprink, T., Imami, K., Günnigmann, M., Zinnall, U., Vieira-Vieira, C.H., Schaub, T., Münster-Wandowski, A., Bürger, J., Borisova, E., Yamamoto, H., Rasin, M.R., Ohler, U., Beule, D., Mielke, T., Tarabykin, V., Landthaler, M., Kramer, G., Vida, I., Selbach, M. and Spahn, C.M.T.
Molecular Cell 81
(2): 304-322.
21 January 2021
VarFish: comprehensive DNA variant analysis for diagnostics and research.
Holtgrewe, M., Stolpe, O., Nieminen, M., Mundlos, S., Knaus, A., Kornak, U., Seelow, D., Segebrecht, L., Spielmann, M., Fischer-Zirnsak, B., Boschann, F., Scholl, U., Ehmke, N. and Beule, D.
Nucleic Acids Research 48
(W1): W162-W169.
2 July 2020
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M., Fischer, A., Goetzke, C.C., Neumaier, H.L., Sauter, M., Kespohl, M., Müller, A.M., Meckes, C., Salbach, C., Schenk, M., Heuser, A., Landmesser, U., Weiner, J., Meder, B., Lehmann, L., Kratzer, A., Klingel, K., Katus, H.A., Kaya, Z. and Beling, A.
Circulation 141
(23): 1885-1902.
9 June 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11
(1): 991.
20 February 2020
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L., Frainay, C., Chazalviel, M., Cabanettes, F., Gloaguen, Y., Camenen, E., Merlet, B., Heux, S., Portais, J.C., Poupin, N., Vinson, F. and Jourdan, F.
Nucleic Acids Research 46
(W1): W495-W502.
2 July 2018
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S., Childs, L.H., Aust, D., Heim, D., Melching, F., Oliveira, C., Wolf, T., Durek, P., Schumacher, D., Blaeker, H., von Winterfeld, M., Gastl, B., Moehr, K., Menne, A., Zeugner, S., Redmer, T., Lenze, D., Tierling, S., Moebs, M., Weichert, W., Folprecht, G., Blanc, E., Beule, D., Schaefer, R., Morkel, M., Klauschen, F., Leser, U. and Sers, C.
Nature Communications 8
: 14093.
25 January 2017
Birchmeier, Walter
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A., Latorre, J., Serena-Maione, A., Espadas, I., Caballano-Infantes, E., Moreno-Navarrete, J.M., Oliveras-Cañellas, N., Ricart, W., Malagón, M.M., Martin-Montalvo, A., Birchmeier, W., Szymanski, W., Graumann, J., Gómez-Serrano, M., Sommariva, E., Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14
(1): 5106.
22 August 2023
Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva, E., Stadiotti, I., Casella, M., Catto, V., Dello Russo, A., Carbucicchio, C., Arnaboldi, L., De Metrio, S., Milano, G., Scopece, A., Casaburo, M., Andreini, D., Mushtaq, S., Conte, E., Chiesa, M., Birchmeier, W., Cogliati, E., Paolin, A., König, E., Meraviglia, V., De Musso, M., Volani, C., Cattelan, G., Rauhe, W., Turnu, L., Porro, B., Pedrazzini, M., Camera, M., Corsini, A., Tondo, C., Rossini, A. and Pompilio, G.
EMBO Molecular Medicine 13
(9): e14365.
7 September 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W.
Cancer Research 81
(8): 2116-2127.
April 2021
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J., Heuberger, J., Vidal, R., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. and Birchmeier, W.
Nature Communications 11
(1): 6422.
21 December 2020
Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H., Franz, A., Jung, M., Weickmann, S., Ralla, B., Kilic, E., Stephan, C., Fendler, A. and Jung, K.
Theranostics 10
(20): 9268-9279.
23 July 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11
(1): 991.
20 February 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11
(1): 929.
17 February 2020
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J., Schang, A.L., Krishnan, M.L., Degos, V., Delahaye-Duriez, A., Bokobza, C., Csaba, Z., Verdonk, F., Montané, A., Sigaut, S., Hennebert, O., Lebon, S., Schwendimann, L., Le Charpentier, T., Hassan-Abdi, R., Ball, G., Aljabar, P., Saxena, A., Holloway, R.K., Birchmeier, W., Baud, O., Rowitch, D., Miron, V., Chretien, F., Leconte, C., Besson, V.C., Petretto, E.G., Edwards, A.D., Hagberg, H., Soussi-Yanicostas, N., Fleiss, B. and Gressens, P.
Brain 142
(12): 3806-3833.
December 2019
Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
Wei, X., Zhang, L., Zhou, Z., Kwon, O.J., Zhang, Y., Nguyen, H., Dumpit, R., True, L., Nelson, P., Dong, B., Xue, W., Birchmeier, W., Taketo, M.M., Xu, F., Creighton, C.J., Ittmann, M.M. and Xin, L.
Cell Stem Cell 24
(5): 753-768.
2 May 2019
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C., Miah, S.M.S., Rota, G., Fonta, N.P., Wang, H., Held, W., Birchmeier, W., Sexl, V., Yang, W., Vivier, E., Ho, P.C., Brossay, L. and Guarda, G.
Nature Communications 10
(1): 1444.
29 March 2019
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A., Huang, J., Györfi, A.H., Matei, A.E., Trinh-Minh, T., Xu, X., Li, Y.N., Chen, C.W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z.Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. and Distler, J.H.W.
Nature Communications 9
(1): 3259.
14 August 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A., Heynen, G.J., Ciecielski, K.J., Ai, J., Berninger, A., Kabacaoglu, D., Görgülü, K., Dantes, Z., Wörmann, S.M., Diakopoulos, K.N., Karpathaki, A.F., Kowalska, M., Kaya-Aksoy, E., Song, L., Zeeuw van der Laan, E.A., López-Alberca, M.P., Nazaré, M., Reichert, M., Saur, D., Erkan, M.M., Hopt, U.T., Sainz, B., Birchmeier, W., Schmid, R.M., Lesina, M. and Algül, H.
Nature Medicine 24
(7): 954-960.
July 2018
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J., Yu, Y., Akilli Öztürk, Ö., Holland, J.D., Besser, D., Fritzmann, J., Wulf-Goldenberg, A., Eckert, K., Fichtner, I. and Birchmeier, W.
Gut 65
(10): 1690-1701.
October 2016
Orchestrating Wnt signalling for metabolic liver zonation.
Birchmeier, W.
Nature Cell Biology 18
(5): 463-465.
May 2016
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M., Agarwal, N., Stösser, S., Bali, K.K., Karaulanov, E., Kamble, R., Pospisilova, B., Kurejova, M., Birchmeier, W., Niehrs, C., Heppenstall, P. and Kuner, R.
Neuron 83
(1): 104-121.
2 July 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I., Gross, J., Baumann, D., Korn, C., Kerr, G., Grigoryan, T., Mauch, C., Birchmeier, W. and Boutros, M.
Journal of Experimental Medicine 210
(9): 1761-1777.
26 August 2013
Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P., Fang, L., Zhu, Q., Schipper, J.H., Loddenkemper, C., Kosel, F., Brinkmann, V., Eckert, K., Hindersin, S., Holland, J.D., Lehr, S., Kahn, M., Ziebold, U. and Birchmeier, W.
EMBO Journal 32
(14): 1977-1989.
17 July 2013
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M., Schuster, S., Juettner, R., Parthasarathy, S., Tarabykin, V. and Birchmeier, W.
Genes & Development 26
(15): 1743-1757.
1 August 2012
Targeting MET in cancer: rationale and progress.
Gherardi, E., Birchmeier, W., Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12
(2): 89-103.
February 2012
BCL9-2 promotes early stages of intestinal tumor progression.
Brembeck, F.H., Wiese, M., Zatula, N., Grigoryan, T., Dai, Y., Fritzmann, J. and Birchmeier, W.
Gastroenterology 141
(4): 1359-1370.
October 2011
Stem cells: Orphan receptors find a home.
Birchmeier, W.
Nature 476
(7360): 287-288.
18 August 2011
Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y., Tomann, P., Andl, T., Gallant, N.M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M.L., Morrisey, E.E., Overbeek, P.A., Scheidereit, C., Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17
(1): 49-61.
21 July 2009
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F.H., Stein, U., Fichtner, I., Schlag, P.M. and Birchmeier, W.
Gastroenterology 137
(11): 165-175.
July 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15
(1): 59-67.
January 2009
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
Grigoryan, T., Wend, P., Klaus, A. and Birchmeier, W.
Genes & Development 22
(17): 2308-2341.
1 September 2008
Wnt signalling and its impact on development and cancer.
Klaus, A. and Birchmeier, W.
Nature Reviews Cancer 8
(5): 387-398.
May 2008
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., Metzger, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W. and Huelsken, J.
Nature 452
(7187): 650-653.
3 April 2008
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G., Scheller, M., Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W., Leutz, A., Huelsken, J. and Held, W.
Blood 111
(1): 142-149.
1 January 2008
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131
(5): 1486-1500.
November 2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7
(10): 1037-1047.
October 2006
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A., Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116
(7): 1825-1828.
July 2006
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
Brembeck, F.H., Rosario, M. and Birchmeier, W.
Current Opinion in Genetics & Development 16
(1): 51-59.
February 2006
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoez, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H. and Wanker, E.E.
Cell 122
(6): 957-968.
23 September 2005
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Hill, T.P., Spaeter, D., Taketo, M.M., Birchmeier, W. and Hartmann, C.
Developmental Cell 8
(5): 727-738.
1 May 2005
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz, G., Rosario, M., Grimm, J., Boeckers, T.M., Gundelfinger, E.D. and Birchmeier, W.
Journal of Cell Biology 167
(5): 945-952.
6 December 2004
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 167
(1): 149-160.
11 October 2004
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. and Birchmeier, W.
Genes & Development 18
(18): 2225-2230.
15 September 2004
Making tubes: Step by step.
Rosario, M. and Birchmeier, W.
Developmental Cell 7
(1): 3-5.
1 July 2004
Met, metastasis, motility and more.
Birchmeier, C., Birchmeier, W., Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4
(12): 915-925.
December 2003
Role of β-catenin in synaptic vesicle localization and presynaptic assembly.
Bamji, S.X., Shimazu, K., Kimes, N., Huelsken, J., Birchmeier, W., Lu, B. and Reichardt, L.F.
Neuron 40
(4): 719-731.
November 2003
How to make tubes: signaling by the Met receptor tyrosine kinase.
Rosario, M. and Birchmeier, W.
Trends in Cell Biology 13
(6): 328-335.
June 2003
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin, Y., Al Ghoul, L., Kepp, O., Meyer, T.E., Birchmeier, W. and Naumann, M.
Journal of Cell Biology 161
(2): 249-255.
28 April 2003
Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R.R., Taketo, M.M., Crenshaw, E.B. and Birchmeier, W.
Genes & Development 17
(16): 1963-1968.
1 January 2003
Deletion of beta-catenin impairs T cell development.
Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. and Sen, J.M.
Nature Immunology 4
(12): 1177-1182.
1 January 2003
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuehl, M., Schaeffer, H.J., Huelsken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W.
Genes & Development 16
(16): 2073-2084.
15 August 2002
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H.E.M., Behrens, J., Sommer, T. and Birchmeier, W.
Nature Cell Biology 4
(3): 222-231.
1 March 2002
New aspects of Wnt signaling pathways in higher vertebrates.
Huelsken, J. and Birchmeier, W.
Current Opinion in Genetics & Development 11
(5): 547-553.
1 October 2001
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm, J., Sachs, M., Britsch, S., Di Cesare, S., Schwarz-Romond, T. and Birchmeier, W.
Journal of Cell Biology 154
(2): 345-354.
23 July 2001
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. and Birchmeier, W.
Cell 105
(4): 533-545.
18 May 2001
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H., Mueller, M., Boehmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W., Ligensa, T., Berndt, A., Kosmehl, H., Gunther, B., Mueller, T., Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152
(2): 325-334.
22 January 2001
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W. and Fodde, R.
Gastroenterology 119
(4): 1045-1053.
1 October 2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M., Brohmann, H., Zechner, D., Mueller, T., Huelsken, J., Walther, I., Schaeper, U., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150
(6): 1375-1384.
18 September 2000
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper, U., Gehring, N.H., Fuchs, K.P., Sachs, M., Kempkes, B. and Birchmeier, W.
Journal of Cell Biology 149
(7): 1419-1432.
26 June 2000
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148
(3): 567-578.
7 February 2000
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
von Kries, J.P., Winbeck, G., Asbrand, C., Schwarz-Romond, T., Sochnikova, N., Dell'Oro, A., Behrens, J. and Birchmeier, W.
Nature Structural Biology 7
: 800-807.
1 January 2000
Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H. and Birchmeier, W.
Journal of Cell Biology 143
(2): 533-545.
19 October 1998
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J., Jerchow, B.A., Wuertele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuehl, M., Wedlich, D. and Birchmeier, W.
Science 280
(5363): 596-599.
24 April 1998
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M., Dicesare, S., Sachs, M., Brinkmann, V., Behrens, J. and Birchmeier, W.
Nature 384
(6605): 173-176.
14 November 1996
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J., von Kries, J.P., Kuehl, M., Bruhn, L., Wedlich, D., Grosschedl, R. and Birchmeier, W.
Nature 382
(6592): 638-642.
15 August 1996
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.
Sachs, M., Weidner, K.M., Brinkmann, V., Walther, I., Obermeier, A., Ullrich, A. and Birchmeier, W.
Journal of Cell Biology 133
(5): 1095-1107.
3 June 1996
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.
Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K.M. and Birchmeier, W.
Journal of Cell Biology 131
(6 Pt. 1): 1573-1586.
December 1995
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift.
Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchmeier, W. and Tsukita, S.
Journal of Cell Biology 131
(6 Pt. 2): 1839-1847.
December 1995
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131
(1): 215-226.
October 1995
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Weidner, K.M., Sachs, M., Riethmacher, D. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 92
: 2597-2601.
1 January 1995
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Huelsken, J., Birchmeier, W. and Behrens, J.
Journal of Cell Biology 127
(6 Pt. 2): 2061-2069.
December 1994
E-cadherin gene mutations in human gastric carcinoma cell lines.
Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S.
Proceedings of the National Academy of Sciences of the United States of America 91
(5): 1858-1862.
1 March 1994
Birchmeier-Kohler, Carmen
Genetic identification of medullary neurons underlying congenital hypoventilation.
Cui, K., Xia, Y., Patnaik, A., Salivara, A., Lowenstein, E.D., Isik, E.G., Knorz, A.L., Airaghi, L., Crotti, M., Garratt, A.N., Meng, F., Schmitz, D., Studer, M., Rijli, F.M., Nothwang, H.G., Rost, B.R., Strauß, U. and Hernandez-Miranda, L.R.
Science Advances 10
(25): eadj0720.
21 June 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9
(92): eadi0042.
2 February 2024
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
Regulation of developmental tempo in different vertebrate species.
Birchmeier, C.
Cell Stem Cell 30
(7): 907-908.
6 July 2023
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13
(1): 6867.
11 November 2022
Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L., Dempsey, B., Garancher, A., Bourane, S., Ruffault, P.L., Morin-Surun, M.P., Rocques, N., Goulding, M., Eychène, A., Pouponnot, C., Fortin, G. and Champagnat, J.
Nature Communications 13
(1): 3284.
7 June 2022
A medullary centre for lapping in mice.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
Nature Communications 12
: 6307.
2 November 2021
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y., Lahmann, I., Baum, K., Shimojo, H., Mourikis, P., Wolf, J., Kageyama, R. and Birchmeier, C.
Nature Communications 12
(1): 1318.
26 February 2021
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13
(1): 713-727.
February 2021
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M., Franke, V., Brandt, B., Lowenstein, E.D., Schöwel, V., Spuler, S., Akalin, A. and Birchmeier, C.
Nature Communications 11
: 6375.
11 December 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
Defining orphan conditions in the context of the European orphan regulation: challenges and evolution.
O'Connor, D.J., Sheean, M.E., Hofer, M.P., Tsigkos, S., Mariz, S., Fregonese, L., Larsson, K., Hivert, V., Westermark, K., Naumann-Winter, F., Stoyanova-Beninska, V., Barišić, I., Capovilla, G., Magrelli, A. and Sepodes, B.
Nature Reviews Drug Discovery 18
(7): 479-480.
July 2019
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T., Braud, S., Jüttner, R., Voigt, B.C., Paulick, K., Sheean, M.E., Klisch, C., Gueneykaya, D., Rathjen, F.G., Geiger, J.R.P., Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37
(17): e98858.
3 September 2018
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357
(6357): eaam8526.
22 September 2017
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A., Gorham, L., Dhandapani, R., Prato, V., Taberner, F.J., Wende, H., Gangadharan, V., Birchmeier, C., Heppenstall, P.A. and Lechner, S.G.
Neuron 93
(1): 179-193.
4 January 2017
Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
Bartus, K., Galino, J., James, N.D., Hernandez-Miranda, L.R., Dawes, J.M., Fricker, F.R., Garratt, A.N., McMahon, S.B., Ramer, M.S., Birchmeier, C., Bennett, D.L.H. and Bradbury, E.J.
Brain 139
(Pt 5): 1394-1416.
May 2016
Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c.
Wiegreffe, C., Simon, R., Peschkes, K., Kling, C., Strehle, M., Cheng, J., Srivatsa, S., Liu, P., Jenkins, N.A., Copeland, N.G., Tarabykin, V. and Britsch, S.
Neuron 87
(2): 311-325.
15 July 2015
Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Loos, M., Mueller, T., Gouwenberg, Y., Wijnands, R., van der Loo, R.J., Birchmeier, C., Smit, A.B. and Spijker, S.
Biological Psychiatry 76
(8): 648-655.
15 October 2014
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V., Furlan, A., Shahidi, M.K., Giovenco, M., Kaukua, N., Konstantinidou, C., Pachnis, V., Memic, F., Marklund, U., Müller, T., Birchmeier, C., Fried, K., Ernfors, P. and Adameyko, I.
Science 345
(6192): 82-87.
4 July 2014
TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D., Rocca, E., Oonk, A.M.M., Schulz, H., Rohde, E., Bednarsch, J., Feenstra, I., Pennings, R.J.E., Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124
(3): 1214-1227.
3 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
BMP signaling controls muscle mass.
Sartori, R., Schirwis, E., Blaauw, B., Bortolanza, S., Zhao, J., Enzo, E., Stantzou, A., Mouisel, E., Toniolo, L., Ferry, A., Stricker, S., Goldberg, A.L., Dupont, S., Piccolo, S., Amthor, H. and Sandri, M.
Nature Genetics 45
(11): 1309-1318.
November 2013
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C., Willem, M., Fricker, F.R., Wende, H., Wulf-Goldenberg, A., Tahirovic, S., Nave, K.A., Saftig, P., Haass, C., Garratt, A.N., Bennett, D.L. and Birchmeier, C.
EMBO Journal 32
(14): 2015-2028.
17 July 2013
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.
Fricker, F.R., Antunes-Martins, A., Galino, J., Paramsothy, R., La Russa, F., Perkins, J., Goldberg, R., Brelstaff, J., Zhu, N., McMahon, S.B., Orengo, C., Garratt, A.N., Birchmeier, C. and Bennett, D.L.
Brain 136
(Pt 7): 2279-2297.
July 2013
A validated regulatory network for Th17 cell specification.
Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C.N., Muratet, M., Newberry, K.M., Meadows, S., Greenfield, A., Yang, Y., Jain, P., Kirigin, F.K., Birchmeier, C., Wagner, E.F., Murphy, K.M., Myers, R.M., Bonneau, R. and Littman, D.R.
Cell 151
(2): 289-303.
12 October 2012
Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D., Vasyutina, E., Czajkowski, M.T., Griger, J., Rassek, C., Rahn, H.P., Purfürst, B., Wende, H. and Birchmeier, C.
Developmental Cell 23
(3): 469-481.
11 September 2012
The transcription factor c-Maf controls touch receptor development and function.
Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. and Birchmeier, C.
Science 335
(6074): 1373-1376.
16 March 2012
Targeting MET in cancer: rationale and progress.
Gherardi, E., Birchmeier, W., Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12
(2): 89-103.
February 2012
Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling.
Van Ho, A.T., Hayashi, S., Broehl, D., Aurade, F., Rattenbach, R. and Relaix, F.
Developmental Cell 21
(2): 273-287.
16 August 2011
A fresh breeze from the ivory tower.
Birchmeier, C.
Current Opinion in Cell Biology 21
(6): 725-726.
December 2009
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
Adameyko, I., Lallemend, F., Aquino, J.B., Pereira, J.A., Topilko, P., Mueller, T., Fritz, N., Beljajeva, A., Mochii, M., Liste, I., Usoskin, D., Suter, U., Birchmeier, C. and Ernfors, P.
Cell 139
(2): 366-379.
16 October 2009
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T., Beed, P., Vogt, J., Schuchmann, S., Maier, N., Kintscher, M., Breustedt, J., Schuelke, M., Streu, N., Kieselmann, O., Brunk, I., Laube, G., Strauss, U., Battefeld, A., Wende, H., Birchmeier, C., Wiese, S., Sendtner, M., Kawabe, H., Kishimoto-Suga, M., Brose, N., Baumgart, J., Geist, B., Aoki, J., Savaskan, N.E., Braeuer, A.U., Chun, J., Ninnemann, O., Schmitz, D. and Nitsch, R.
Cell 138
(6): 1222-12235.
18 September 2009
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice.
Giebeler, A., Boekschoten, M.V., Klein, C., Borowiak, M., Birchmeier, C., Gassler, N., Wasmuth, H.E., Mueller, M., Trautwein, C. and Streetz, K.L.
Gastroenterology 137
(1): 297-308.
July 2009
Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex.
Farkas, L.M., Haffner, C., Giger, T., Khaitovich, P., Nowick, K., Birchmeier, C., Paeaebo, S. and Huttner, W.B.
Neuron 60
(1): 40-55.
9 October 2008
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brinkmann, B.G., Agarwal, A., Sereda, M.W., Garratt, A.N., Mueller, T., Wende, H., Stassart, R.M., Nawaz, S., Humml, C., Velanac, V., Radyushkin, K., Goebbels, S., Fischer, T.M., Franklin, R.J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M.H. and Nave, K.A.
Neuron 59
(4): 581-595.
28 August 2008
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori, K., Cholewa-Waclaw, J., Nakada, Y., Glasgow, S.M., Masui, T., Henke, R.M., Wildner, H., Martarelli, B., Beres, T.M., Epstein, J.A., Magnuson, M.A., Macdonald, R.J., Birchmeier, C. and Johnson, J.E.
Genes & Development 22
(2): 166-178.
15 January 2008
Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N., Frahm, C., Gassmann, M., Griffel, C., Erdmann, B., Birchmeier, C., Lewin, G.R. and Garratt, A.N.
Neuron 56
(5): 893-906.
6 December 2007
Notch signaling is essential for ventricular chamber development.
Grego-Bessa, J., Luna-Zurita, L., del Monte, G., Bolos, V., Melgar, P., Arandilla, A., Garratt, A.N., Zang, H., Mukouyama, Y.S., Chen, H., Shou, W., Ballestar, E., Esteller, M., Rojas, A., Perez-Pomares, J.M. and de la Pompa, J.L.
Developmental Cell 12
(3): 415-429.
March 2007
Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., Destrooper, B., Saftig, P., Birchmeier, C. and Haass, C.
Science 314
(5799): 664-666.
27 October 2006
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
Gierl, M.S., Karoulias, N., Wende, H., Strehle, M. and Birchmeier, C.
Genes & Development 20
(17): 2465-2478.
1 September 2006
Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lopez-Bendito, G., Cautinat, A., Sanchez, J.A., Bielle, F., Flames, N., Garratt, A.N., Talmage, D.A., Role, L.W., Charnay, P., Marin, O. and Garel, S.
Cell 125
(1): 127-142.
7 April 2006
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E. and Birchmeier, C.
Genes & Development 19
(18): 2187-2198.
15 September 2005
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C.
Genes & Development 19
(6): 733-743.
1 January 2005
A role for E2F6 in the restriction of male-germ-cell-specific gene expression.
Pohlers, M., Truss, M., Frede, U., Scholz, A., Strehle, M., Kuban, R.J., Hoffmann, B., Morkel, M., Birchmeier, C. and Hagemeier, C.
Current Biology 15
(11): 1051-1057.
1 January 2005
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Graveel, C., Su, Y., Koeman, J., Wang, L.M., Tessarollo, L., Fiscella, M., Birchmeier, C., Swiatek, P., Bronson, R. and Vande Woude, G.F.
Proceedings of the National Academy of Sciences of the United States of America 101
(49): 17198-17203.
7 December 2004
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Flames, N., Long, J.E., Garratt, A.N., Fischer, T.M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J.L. and Marin, O.
Neuron 44
(2): 251-261.
14 October 2004
Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H. and Nave, K.A.
Science 304
(5671): 700-703.
30 April 2004
Met provides essential signals for liver regeneration.
Borowiak, M., Garratt, A.N., Wuestefeld, T., Strehle, M., Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101
(29): 10608-10613.
1 January 2004
Met, metastasis, motility and more.
Birchmeier, C., Birchmeier, W., Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4
(12): 915-925.
December 2003
A role for Neuregulin1 signaling in muscle spindle differentiation.
Hippenmeyer, S., Shneider, N.A., Birchmeier, C., Burden, S.J., Jessell, T.M. and Arber, S.
Neuron 36
(6): 1035-1049.
19 December 2002
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
Mukouyama, Y., Shin, D., Britsch, S., Taniguchi, M. and Anderson, D.J.
Cell 109
(6): 693-705.
14 June 2002
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M. and Birchmeier, C.
Neuron 34
(4): 551-562.
16 May 2002
Genomics boosts mouse molecular genetics.
Birchmeier, C. and Treier, M.
Trends in Genetics 17
(12): 691-692.
1 December 2001
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H., Mueller, M., Boehmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W., Ligensa, T., Berndt, A., Kosmehl, H., Gunther, B., Mueller, T., Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152
(2): 325-334.
22 January 2001
The transcription factor Sox10 is a key regulator of peripheral glial development.
Britsch, S., Goerich, D.E., Riethmacher, D., Peirano, R.I., Rossner, M., Nave, K.A., Birchmeier, C. and Wegner, M.
Genes & Development 15
(1): 66-78.
1 January 2001
Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.
Yang, X., Arber, S., William, C., Li, L., Tanabe, Y., Jessell, T.M., Birchmeier, C. and Burden, S.J.
Neuron 30
(2): 399-410.
1 January 2001
Genes that control the development of migrating muscle precursor cells.
Birchmeier, C. and Brohmann, H.
Current Opinion in Cell Biology 12
(6): 725-730.
1 December 2000
Cell differentiation.
Rosenthal, N. and Birchmeier, C.
Current Opinion in Cell Biology 12
: 717-718.
1 December 2000
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W. and Fodde, R.
Gastroenterology 119
(4): 1045-1053.
1 October 2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M., Brohmann, H., Zechner, D., Mueller, T., Huelsken, J., Walther, I., Schaeper, U., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150
(6): 1375-1384.
18 September 2000
A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool.
Garratt, A.N., Voiculescu, O., Topilko, P., Charnay, P. and Birchmeier, C.
Journal of Cell Biology 148
(5): 1035-1046.
6 March 2000
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148
(3): 567-578.
7 February 2000
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Woldeyesus, M.T., Britsch, S., Riethmacher, D., Xu, L., Sonnenberg-Riethmacher, E., Abou-Rebyeh, F., Harvey, R., Caroni, P. and Birchmeier, C.
Genes & Development 13
: 2538-2548.
1 October 1999
The role of SF/HGF and c-Met in the development of skeletal muscle.
Dietrich, S., Abou-Rebyeh, F., Brohmann, H., Bladt, F., Yamaai, T., Lumsden, A., Brand-Saberi, B. and Birchmeier, C.
Development 126
: 1621-1629.
1 April 1999
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
Birchmeier, C. and Gherardi, E.
Trends in Cell Biology 8
(10): 404-410.
1 October 1998
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C. and Riethmacher, D.
Genes & Development 12
: 1825-1836.
1 January 1998
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons.
Ebens, A., Brose, K., Leonardo, E.D., Hanson, M.G., Bladt, F., Birchmeier, C., Barres, B.A. and Tessierlavigne, M.
Neuron 17
(6): 1157-1172.
1 December 1997
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G.R. and Birchmeier, C.
Nature 389
(6652): 725-730.
16 October 1997
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.
Sonnenberg-Riethmacher, E., Walter, B., Riethmacher, D., Goedecke, S. and Birchmeier, C.
Genes & Development 10
(10): 1184-1193.
1 January 1996
Multiple essential functions of neuregulin in development.
Meyer, D. and Birchmeier, C.
Nature 378
(6555): 386-390.
23 November 1995
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131
(1): 215-226.
October 1995
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. and Birchmeier, C.
Nature 376
(6543): 768-771.
31 August 1995
Scatter factor/hepatocyte growth factor is essential for liver development.
Schmidt, C., Bladt, F., Goedecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M., Gherardi, E. and Birchmeier, C.
Nature 373
(6515): 699-702.
23 February 1995
Blankenstein, Thomas
Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143
(14): 1365-1378.
4 April 2024
Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 11
(3): e006784.
14 March 2023
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24
(3): 414-422.
March 2023
Diverse effects of obesity on antitumor immunity and immunotherapy.
Dyck, L. and Lynch, L.
Trends in Molecular Medicine 29
(2): 112-123.
February 2023
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy.
Plewa, N., Poncette, L. and Blankenstein, T.
Journal for ImmunoTherapy of Cancer 11
(2): e006001.
February 2023
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10
(10): e005535.
27 October 2022
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L., Pick, R., Montorfani, J., Sun, M., Brighouse, D., Liaudet, N., Kammertoens, T., Blankenstein, T., Page, N., Bernier-Latamani, J., Tran, N.L., Petrova, T.V., Merkler, D., Scheiermann, C. and Hugues, S.
Science Advances 8
(23): eabl5162.
8 June 2022
"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T., Kemna, J. and Leisegang, M.
EMBO Molecular Medicine 12
(2): e11801.
7 February 2020
Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L., Chen, X., Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129
(1): 324-335.
2 January 2019
Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T., Blankenstein, T. and Willimsky, G.
Blood 132
(9): 924-934.
30 August 2018
Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
Chen, X., Poncette, L. and Blankenstein, T.
Journal of Experimental Medicine 214
(11): 3417-3433.
6 November 2017
T cell receptors for clinical therapy: in vitro assessment of toxicity risk.
Kunert, A., Obenaus, M., Lamers, C.H.J., Blankenstein, T. and Debets, R.
Clinical Cancer Research 23
(20): 6012-6020.
15 October 2017
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S., Zharkov, D.O., Stahl, J., Gopanenko, Al.V., Tupikin, A.E., Kabilov, M.R., Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45
(7): 3833-3843.
20 April 2017
Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
Textor, A., Schmidt, K., Kloetzel, P.M., Weißbrich, B., Perez, C., Charo, J., Anders, K., Sidney, J., Sette, A., Schumacher, T.N.M., Keller, C., Busch, D.H., Seifert, U. and Blankenstein, T.
Journal of Experimental Medicine 213
(11): 2333-2348.
17 October 2016
Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E., Hilgenberg, E., Stervbo, U., Lampropoulou, V., Shen, P., Bunse, M., Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44
(5): 1114-1126.
17 May 2016
Receptor combinations hone T-cell therapy.
Blankenstein, T.
Nature Biotechnology 34
(4): 389-391.
7 April 2016
Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M., Kammertoens, T., Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126
(3): 854-858.
1 March 2016
Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M., Leitão, C., Leisegang, M., Chen, X., Gavvovidis, I., van der Bruggen, P., Uckert, W., Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33
(4): 402-407.
April 2015
MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125
(2): 699-714.
2 February 2015
High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C., Heemskerk, B., Kvistborg, P., Kluin, R.J.C., Bolotin, D.A., Chen, X., Bresser, K., Nieuwland, M., Schotte, R., Michels, S., Gomez-Eerland, R., Jahn, L., Hombrink, P., Legrand, N., Shu, C.J., Mamedov, I.Z., Velds, A., Blank, C.U., Haanen, J.B.A.G., Turchaninova, M.A., Kerkhoven, R.M., Spits, H., Hadrup, S.R., Heemskerk, M.H.M., Blankenstein, T., Chudakov, D.M., Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19
(11): 1534-1541.
November 2013
It's the peptide-MHC affinity, stupid.
Kammertoens, T. and Blankenstein, T.
Cancer Cell 23
(4): 429-431.
15 April 2013
Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G., Schmidt, K., Loddenkemper, C., Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123
(3): 1032-1043.
1 March 2013
The determinants of tumour immunogenicity.
Blankenstein, T., Coulie, P.G., Gilboa, E. and Jaffee, E.M.
Nature Reviews Cancer 12
(4): 307-313.
April 2012
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders, K., Buschow, C., Herrmann, A., Milojkovic, A., Loddenkemper, C., Kammertoens, T., Daniel, P., Yu, H., Charo, J. and Blankenstein, T.
Cancer Cell 20
(6): 755-767.
13 December 2011
Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N., Fujimoto, M., Tan, K., Prakasam, R., Shinkawa, T., Li, L., Ichikawa, H., Takii, R. and Nakai, A.
EMBO Journal 29
(20): 3459-3469.
20 October 2010
Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P., Lampert, J.C., Chen, X., Leitao, C., Popovic, J., Mueller, W. and Blankenstein, T.
Nature Medicine 16
(9): 1029-1034.
September 2010
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky, G., Czeh, M., Loddenkemper, C., Gellermann, J., Schmidt, K., Wust, P., Stein, H. and Blankenstein, T.
Journal of Experimental Medicine 205
(7): 1687-1700.
7 July 2008
The adaptive immune response to sporadic cancer.
Willimsky, G. and Blankenstein, T.
Immunological Reviews 220
(1): 102-112.
December 2007
Active MAC-1 (CD11b/CD18) on DC is inhibitory for full T cell activation.
Varga, G., Balkow, S., Wild, M.K., Stadtbaeumer, A., Krummen, M., Rothoeft, T., Higuchi, T., Beissert, S., Wethmar, K., Scharffetter-Kochanek, K., Vestweber, D. and Grabbe, S.
Blood 109
(2): 661-669.
15 January 2007
Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. and Blankenstein, T.
Nature 437
(7055): 141-146.
1 September 2005
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G. and Foerster, R.
Immunity 21
(2): 279-288.
1 August 2004
A cancer immunosurveillance controversy.
Qin, Z.H. and Blankenstein, T.
Nature Immunology 5
(1): 3-4.
1 January 2004
Tumor rejection by modulation of tumor stromal fibroblasts.
Schueler, T., Koernig, S. and Blankenstein, T.
Journal of Experimental Medicine 198
(10): 1487-1493.
17 November 2003
The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.
Blankenstein, T. and Qin, Z.H.
Current Opinion in Immunology 15
(2): 148-154.
April 2003
Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions.
Aicher, A., Heeschen, C., Mohaupt, M., Cooke, J.P., Zeiher, A.M. and Dimmeler, S.
Circulation 107
(4): 604-611.
4 February 2003
Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction.
Qin, Z., Kim, H.J., Hemme, J. and Blankenstein, T.
Journal of Experimental Medicine 195
(11): 1479-1490.
3 June 2002
Cross-priming versus cross-tolerance: are two signals enough?
Blankenstein, T. and Schueler, T.
Trends in Immunology 23
(4): 171-173.
1 April 2002
Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T., Kammertoens, T., Preiss, S., Debs, P., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194
(12): 1767-1775.
17 December 2001
Tumor rejection by disturbing tumor stroma cell interactions.
Ibe, S., Qin, Z.H., Schueler, T., Preiss, S. and Blankenstein, T.
Journal of Experimental Medicine 194
(11): 1549-1559.
3 December 2001
Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.
Becker, C., Pohla, H., Frankenberger, B., Schueler, T., Assenmacher, M., Schendel, D.J. and Blankenstein, T.
Nature Medicine 7
(10): 1159-1162.
1 January 2001
CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNgamma receptor expression by nonhematopoietic cells.
Qin, Z.H. and Blankenstein, T.
Immunity 12
(6): 677-686.
1 June 2000
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 8699-8704.
20 July 1999
T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice.
Schueler, T., Qin, Z., Ibe, S., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 189
(5): 803-810.
1 March 1999
Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels.
Lange, C., Schueler, T. and Blankenstein, T.
Journal of Experimental Medicine 187
(9): 1487-1493.
4 May 1998
B cells inhibit induction of T cell-dependent tumor immunity.
Qin, Z.H., Richter, G., Schueler, T., Ibe, S., Cao, X.T. and Blankenstein, T.
Nature Medicine 4
: 627-630.
1 January 1998
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, D., Veromaa, T., Waisman, A., Gaur, A., Conlon, P., Ling, N., Fairchild, P.J., Wraith, D.C., Ogarra, A., Fathman, C.G. and Steinman, L.
Nature 379
(6563): 343-346.
1 January 1996
Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.
Qin, Z., Krueger-Krasagakes, S., Kunzendorf, U., Hock, H., Diamantstein, T. and Blankenstein, T.
Journal of Experimental Medicine 178
(1): 355-360.
1 July 1993
Boschmann, Michael (ECRC)
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
(3): 863-875.
1 March 2021
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H., Schröder, A., Neuhofer, W., Jantsch, J., Kopp, C., Karlsen, T.V., Boschmann, M., Goss, J., Bry, M., Rakova, N., Dahlmann, A., Brenner, S., Tenstad, O., Nurmi, H., Mervaala, E., Wagner, H., Beck, F.X., Müller, D.N., Kerjaschki, D., Luft, F.C., Harrison, D.G., Alitalo, K. and Titze, J.
Journal of Clinical Investigation 123
(7): 2803-2815.
1 July 2013
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187
(4): 387-396.
15 February 2013
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
Haufe, S., Engeli, S., Kast, P., Boehnke, J., Utz, W., Haas, V., Hermsdorf, M., Maehler, A., Wiesner, S., Birkenfeld, A.L., Sell, H., Otto, C., Mehling, H., Luft, F.C., Eckel, J., Schulz-Menger, J., Boschmann, M. and Jordan, J.
Hepatology 53
(5): 1504-1514.
May 2011
Britsch, Stefan
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C.
Genes & Development 19
(6): 733-743.
1 January 2005
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
Mukouyama, Y., Shin, D., Britsch, S., Taniguchi, M. and Anderson, D.J.
Cell 109
(6): 693-705.
14 June 2002
Bullinger, Lars
Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Ihlow, J., Penter, L., Vuong, L.G., Bischoff, P., Obermayer, B., Trinks, A., Blau, O., Behnke, A., Conrad, T., Morkel, M., Wu, C.J., Westermann, J., Bullinger, L., von Brünneck, A.C., Blüthgen, N., Horst, D. and Praktiknjo, S.D.
Med
6 December 2024
(In Press)
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
Leppä, A.M., Grimes, K., Jeong, H., Huang, F.Y., Andrades, A., Waclawiczek, A., Boch, T., Jauch, A., Renders, S., Stelmach, P., Müller-Tidow, C., Karpova, D., Sohn, M., Grünschläger, F., Hasenfeld, P., Benito Garagorri, E., Thiel, V., Dolnik, A., Rodriguez-Martin, B., Bullinger, L., Mrózek, K., Eisfeld, A.K., Krämer, A., Sanders, A.D., Korbel, J.O. and Trumpp, A.
Nature Genetics 56
(12): 2790-2803.
December 2024
New cardiovascular biomarkers in patients with advanced cancer – a prospective study comparing MR-proADM, MR-proANP, copeptin, high-sensitivity troponin T and NT-proBNP.
Anker, M.S., Lück, L.C., Khan, M.S., Porthun, J., Hadzibegovic, S., Lena, A., Wilkenshoff, U., Weinländer, P., Evertz, R., Totzeck, M., Mahabadi, A.A., Rassaf, T., Anker, S.D., Bullinger, L., Keller, U., Karakas, M., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure
26 November 2024
(In Press)
Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations.
Penter, L., Cieri, N., Maurer, K., Kwok, M., Lyu, H., Lu, W.S., Oliveira, G., Gohil, S.H., Leshchiner, I., Lareau, C.A., Ludwig, L.S., Neuberg, D.S., Kim, H.T., Li, S., Bullinger, L., Ritz, J., Getz, G., Garcia, J.S., Soiffer, R.J., Livak, K.J. and Wu, C.J.
Blood Cancer Discovery 5
(6): 442-459.
1 November 2024
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy.
Gross, S., Ihlow, J., Busack, L., Adamiak, K., Schrezenmeier, J., Jesse, J., Schwarz, M., Flörcken, A., Vuong, L.G., Rieger, K., Krönke, J., le Coutre, P., Boldt, V., von Brünneck, A.C., Horst, D., Burmeister, T., Blau, I.W., Keller, U., Bullinger, L. and Westermann, J.
Blood Cancer Journal 14
(1): 160.
16 September 2024
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer.
Arends, C.M., Kopp, K., Hablesreiter, R., Estrada, N., Christen, F., Moll, U.M., Zeillinger, R., Schmitt, W.D., Sehouli, J., Kulbe, H., Fleischmann, M., Ray-Coquard, I., Zeimet, A., Raspagliesi, F., Zamagni, C., Vergote, I., Lorusso, D., Concin, N., Bullinger, L., Braicu, E.I. and Damm, F.
Leukemia 38
(6): 1378-1389.
June 2024
Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143
(14): 1365-1378.
4 April 2024
Genetic characterization of primary mediastinal B-cell lymphoma: pathogenesis and patient outcomes.
Noerenberg, D., Briest, F., Hennch, C., Yoshida, K., Hablesreiter, R., Takeuchi, Y., Ueno, H., Staiger, A.M., Ziepert, M., Asmar, F., Locher, B.N., Toth, E., Weber, T., Amini, R.M., Klapper, W., Bouzani, M., Poeschel, V., Rosenwald, A., Held, G., Campo, E., Ishaque, N., Stamatopoulos, K., Kanellis, G., Anagnostopoulos, I., Bullinger, L., Goldschmidt, N., Zinzani, P.L., Bödör, C., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Journal of Clinical Oncology 42
(4): 452-466.
1 February 2024
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.
Bruedigam, C., Porter, A.H., Song, A., Vroeg In de Wei, G., Stoll, T., Straube, J., Cooper, L., Cheng, G., Kahl, V.F.S., Sobinoff, A.P., Ling, V.Y., Jebaraj, B.M.C., Janardhanan, Y., Haldar, R., Bray, L.J., Bullinger, L., Heidel, F.H., Kennedy, G.A., Hill, M.M., Pickett, H.A., Abdel-Wahab, O., Hartel, G. and Lane, S.W.
Nature Cancer 5
(1): 47-65.
January 2024
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37
(11): 2237-2249.
November 2023
Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients.
Jahn, E., Saadati, M., Fenaux, P., Gobbi, M., Roboz, G.J., Bullinger, L., Lutsik, P., Riedel, A., Plass, C., Jahn, N., Walter, C., Holzmann, K., Hao, Y., Naim, S., Schreck, N., Krzykalla, J., Benner, A., Keer, H.N., Azab, M., Döhner, K. and Döhner, H.
Leukemia 37
(11): 2187-2196.
November 2023
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Eifert, T., Hsu, C.J., Becker, A.L., Graessle, S., Horne, A., Bemmann, F., Zhang, Q., Heuser, M., Vasioukhin, V., Scholl, S., Hochhaus, A., Siegerist, F., Endlich, N., Bullinger, L., Lane, S.W., Haas, S., Schnoeder, T.M and Heidel, F.H.
Leukemia 37
(10): 2027-2035.
October 2023
Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
Rejeski, K., Perez, A., Iacoboni, G., Blumenberg, V., Bücklein, V.L., Völkl, S., Penack, O., Albanyan, O., Stock, S., Müller, F., Karschnia, P., Petrera, A., Reid, K., Faramand, R., Davila, M.L., Modi, K., Dean, E.A., Bachmeier, C., von Bergwelt-Baildon, M., Locke, F.L., Bethge, W., Bullinger, L., Mackensen, A., Barba, P., Jain, M.D. and Subklewe, M.
Science Advances 9
(38): eadg3919.
22 September 2023
Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire.
Anker, M.S., Potthoff, S.K., Lena, A., Porthun, J., Hadzibegovic, S., Evertz, R., Denecke, C., Fröhlich, A.K., Sonntag, F., Regitz-Zagrosek, V., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Spertus, J.A., Anker, S.D., Karakas, M., Bullinger, L., Keller, U., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure 25
(9): 1635-1647.
September 2023
Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09-09): a randomised, open-label, multicentre, phase 3 trial.
Döhner, H., Weber, D., Krzykalla, J., Fiedler, W., Kühn, M.W.M., Schroeder, T., Mayer, K., Lübbert, M., Wattad, M., Götze, K., Fransecky, L., Koller, E., Wulf, G., Schleicher, J., Ringhoffer, M., Greil, R., Hertenstein, B., Krauter, J., Martens, U.M., Nachbaur, D., Samra, M.A., Machherndl-Spandl, S., Basara, N., Leis, C., Schrade, A., Kapp-Schwoerer, S., Cocciardi, S., Bullinger, L., Thol, F., Heuser, M., Paschka, P., Gaidzik, V.I., Saadati, M., Benner, A., Schlenk, R.F., Döhner, K. and Ganser, A.
Lancet Haematology 10
(7): e495-e509.
July 2023
Clinical and prognostic relevance of cardiac wasting in patients with advanced cancer.
Lena, A., Wilkenshoff, U., Hadzibegovic, S., Porthun, J., Rösnick, L., Fröhlich, A.K., Zeller, T., Karakas, M., Keller, U., Ahn, J., Bullinger, L., Riess, H., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Totzeck, M., Rassaf, T., Burkhoff, D., Mehra, M.R., Bax, J.J., Butler, J., Edelmann, F., Haverkamp, W., Anker, S.D., Packer, M., Coats, A.J.S., von Haehling, S., Landmesser, U. and Anker, M.S.
Journal of the American College of Cardiology 81
(16): 1569-1586.
25 April 2023
Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
Straube, J., Eifert, T., Vu, T., Janardhanan, Y., Haldar, R., von Eyss, B., Cooper, L., Bruedigam, C., Ling, V.Y., Cooper, E., Patch, A.M., Bullinger, L., Schnoeder, T.M., Bywater, M., Heidel, F.H. and Lane, S.W.
Leukemia 37
(4): 741-750.
April 2023
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.
Arends, C.M., Liman, T.G., Strzelecka, P.M., Kufner, A., Löwe, P., Huo, S., Stein, C.M., Piper, S.K., Tilgner, M., Sperber, P.S., Dimitriou, S., Heuschmann, P., Hablesreiter, R., Harms, C., Bullinger, L., Weber, J.E., Endres, M. and Damm, F.
Blood 141
(7): 787-799.
16 February 2023
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
Mansouri, L., Thorvaldsdottir, B., Sutton, L.A., Karakatsoulis, G., Meggendorfer, M., Parker, H., Nadeu, F., Brieghel, C., Laidou, S., Moia, R., Rossi, D., Catherwood, M., Kotaskova, J., Delgado, J., Rodríguez-Vicente, A.E., Benito, R., Rigolin, G.M., Bonfiglio, S., Scarfo, L., Mattsson, M., Davis, Z., Gogia, A., Rani, L., Baliakas, P., Foroughi-Asl, H., Jylhä, C., Skaftason, A., Rapado, I., Miras, F., Martinez-Lopez, J., de la Serna, J., Rivas, J.M.H., Thornton, P., Larráyoz, M.J., Calasanz, M.J., Fésüs, V., Mátrai, Z., Bödör, C., Smedby, K.E., Espinet, B., Puiggros, A., Gupta, R., Bullinger, L., Bosch, F., Tazón-Vega, B., Baran-Marszak, F., Oscier, D., Nguyen-Khac, F., Zenz, T., Terol, M.J., Cuneo, A., Hernández-Sánchez, M., Pospisilova, S., Mills, K., Gaidano, G., Niemann, C.U., Campo, E., Strefford, J.C., Ghia, P., Stamatopoulos, K. and Rosenquist, R.
Leukemia 37
(2): 339-347.
February 2023
Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.
Denkinger, C.M., Janssen, M., Schäkel, U., Gall, J., Leo, A., Stelmach, P., Weber, S.F., Krisam, J., Baumann, L., Stermann, J., Merle, U., Weigand, M.A., Nusshag, C., Bullinger, L., Schrezenmeier, J.F., Bornhäuser, M., Alakel, N., Witzke, O., Wolf, T., Vehreschild, M.J.G.T., Schmiedel, S., Addo, M.M., Herth, F., Kreuter, M., Tepasse, P.R., Hertenstein, B., Hänel, M., Morgner, A., Kiehl, M., Hopfer, O., Wattad, M.A., Schimanski, C.C., Celik, C., Pohle, T., Ruhe, M., Kern, W.V., Schmitt, A., Lorenz, H.M., Souto-Carneiro, M., Gaeddert, M., Halama, N., Meuer, S., Kräusslich, H.G., Müller, B., Schnitzler, P., Parthé, S., Bartenschlager, R., Gronkowski, M., Klemmer, J., Schmitt, M., Dreger, P., Kriegsmann, K., Schlenk, Ri.F. and Müller-Tidow, C.
Nature Cancer 4
(1): 96-107.
January 2023
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia.
Ling, V.Y., Straube, J., Godfrey, W., Haldar, R., Janardhanan, Y., Cooper, L., Bruedigam, C., Cooper, E., Tavakoli Shirazi, P., Jacquelin, S., Tey, S.K., Baell, J., Huang, F., Jin, J., Zhao, Y., Bullinger, L., Bywater, M.J. and Lane, S.W.
Leukemia 37
(1): 143-153.
January 2023
TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
Brauneck, F., Fischer, B., Witt, M., Muschhammer, J., Oelrich, J., da Costa Avelar, P.H., Tsoka, S., Bullinger, L., Seubert, E., Smit, D.J., Bokemeyer, C., Ackermann, C., Wellbrock, J., Haag, F. and Fiedler, W.
Journal for ImmunoTherapy of Cancer 10
(12): e004794.
22 December 2022
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N., Jahn, E., Saadati, M., Bullinger, L., Larson, R.A., Ottone, T., Amadori, S., Prior, T.W., Brandwein, J.M., Appelbaum, F.R., Medeiros, B.C., Tallman, M.S., Ehninger, G., Heuser, M., Ganser, A., Pallaud, C., Gathmann, I., Krzykalla, J., Benner, A., Bloomfield, C.D., Thiede, C., Stone, R.M., Döhner, H. and Döhner, K.
Leukemia 36
(9): 2218-2227.
September 2022
Precision medicine in myeloid malignancies.
Westermann, J. and Bullinger, L.
Seminars in Cancer Biology 84
: 153-169.
September 2022
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.
Zhai, Y., Singh, P., Dolnik, A., Brazda, P., Atlasy, N., Del Gaudio, N., Döhner, K., Döhner, H., Minucci, S., Martens, J., Altucci, L., Megchelenbrink, W., Bullinger, L. and Stunnenberg, H.G.
Molecular Cancer 21
(1): 166.
19 August 2022
Unified classification and risk-stratification in Acute Myeloid Leukemia.
Tazi, Y., Arango-Ossa, J.E., Zhou, Y., Bernard, E., Thomas, I., Gilkes, A., Freeman, S., Pradat, Y., Johnson, S.J., Hills, R., Dillon, R., Levine, M.F., Leongamornlert, D., Butler, A., Ganser, A., Bullinger, L., Döhner, K., Ottmann, O., Adams, R., Döhner, H., Campbell, P.J., Burnett, A.K., Dennis, M., Russell, N.H., Devlin, S.M., Huntly, B.J.P. and Papaemmanuil, E.
Nature Communications 13
(1): 4622.
8 August 2022
The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
Grasedieck, S., Cabantog, A., MacPhee, L., Im, J., Ruess, C., Demir, B., Sperb, N., Rücker, F.G., Döhner, K., Herold, T., Pollack, J.R., Bullinger, L., Rouhi, A. and Kuchenbauer, F.
Haematologica 107
(8): 1758-1772.
August 2022
Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
Ihlow, J., Gross, S., Busack, L., Flörcken, A., Jesse, J., Schwarz, M., Neuendorff, N.R., von Brünneck, A.C., Anagnostopoulos, I., Türkmen, S., Blau, I.W., Burmeister, T., Horst, D., Bullinger, L. and Westermann, J.
Haematologica 107
(8): 1773-1785.
August 2022
The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
Viñado, A.C., Calvo, I.A., Cenzano, I., Olaverri, D., Cocera, M., San Martin-Uriz, P., Romero, J.P., Vilas-Zornoza, A., Vera, L., Gomez-Cebrian, N., Puchades-Carrasco, L., Lisi-Vega, L.E., Apaolaza, I., Valera, P., Guruceaga, E., Granero-Molto, F., Ripalda-Cemborain, P., Luck, T.J., Bullinger, L., Planes, F.J., Rifon, J.J., Méndez-Ferrer, S., Yusuf, R.Z., Pardo-Saganta, A., Prosper, F. and Saez, B.
Leukemia 36
(8): 1969-1979.
August 2022
Application of precision medicine in clinical routine in haematology - challenges and opportunities.
Wästerlid, T., Cavelier, L., Haferlach, C., Konopleva, M., Fröhling, S., Östling, P., Bullinger, L., Fioretos, T. and Smedby, K.E.
Journal of Internal Medicine 292
(2): 243-261.
August 2022
Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity.
Feldkamp, J.D., Vetter, V.M., Arends, C.M., Lang, T.J.L., Bullinger, L., Damm, F., Demuth, I. and Frick, M.
Haematologica 107
(7): 1703-1708.
July 2022
Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma.
Schmiester, M., Maier, R., Riedel, R., Durek, P., Frentsch, M., Kolling, S., Mashreghi, M.F., Jenq, R., Zhang, L., Peterson, C.B., Bullinger, L., Chang, H.D. and Na, I.K.
Gut Microbes 14
(1): e2081475.
29 May 2022
The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.
Rejeski, K., Perez, A., Iacoboni, G., Penack, O., Bücklein, V., Jentzsch, L., Mougiakakos, D., Johnson, G., Arciola, B., Carpio, C., Blumenberg, V., Hoster, E., Bullinger, L., Locke, F.L., von Bergwelt-Baildon, M., Mackensen, A., Bethge, W., Barba, P., Jain, M.D. and Subklewe, M.
Journal for ImmunoTherapy of Cancer 10
(5): e004475.
17 May 2022
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P., Vonficht, D., Schnell, A., Uckelmann, H.J., Bollhagen, A., Mahmoud, M.A.A., Landua, S.L., van der Salm, E., Trautmann, C., Raffel, S., Grünschläger, F., Lutz, R., Ghosh, M., Renders, S., Correia, N., Donato, E., Dixon, K.O., Hirche, C., Andresen, C., Robens, Cl., Werner, P.S., Boch, T., Eisel, D., Osen, W., Pilz, F., Przybylla, A., Klein, C., Buchholz, F., Milsom, M.D., Essers, M.A.G., Eichmüller, S.B., Hofmann, W.K., Nowak, D., Hübschmann, D., Hundemer, M., Thiede, C., Bullinger, L., Müller-Tidow, C., Armstrong, S.A., Trumpp, A., Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29
(5): 760-775.
5 May 2022
Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN).
Maschmeyer, G., Bullinger, L., Garcia-Vidal, C., Herbrecht, R., Maertens, J., Menna, P., Pagano, L., Thiebaut-Bertrand, A. and Calandra, T.
Leukemia 36
(5): 1215-1226.
May 2022
Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F. and Damm, F.
Leukemia 36
(4): 1102-1110.
April 2022
Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial.
Arends, C.M., Dimitriou, S., Stahler, A., Hablesreiter, R., Strzelecka, P.M., Stein, C.M., Tilgner, M., Saiki, R., Ogawa, S., Bullinger, L., Modest, D.P., Stintzing, S., Heinemann, V. and Damm, F.
Blood 139
(10): 1593-1597.
10 March 2022
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13
(1): 1009.
23 February 2022
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Schnoeder, T.M., Schwarzer, A., Jayavelu, A.K., Hsu, C.J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S.A., Nafria, M., Jiang, L., Dai, Y.T., Chen, Z., Chen, S.J., Kellaway, S.G., Ptasinska, A., Ng, E.S., Stanley, E.G., Elefanty, A.G., Buschbeck, M., Bierhoff, H., Brodt, S., Matziolis, G., Fischer, K.D., Hochhaus, A., Chen, C.W., Heidenreich, O., Mann, M., Lane, S.W., Bullinger, L., Ori, A., von Eyss, B., Bonifer, C. and Heidel, F.
Blood 139
(7): 1080-1097.
17 February 2022
CEBPA mutations in AML: site matters.
Bullinger, L.
Blood 139
(1): 6-7.
6 January 2022
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
Rücker, F.G., Du, L., Luck, T.J., Benner, A., Krzykalla, J., Gathmann, I., Voso, M.T., Amadori, S., Prior, T.W., Brandwein, J.M., Appelbaum, F.R., Medeiros, B.C., Tallman, M.S., Savoie, L., Sierra, J., Pallaud, C., Sanz, M.A., Jansen, J.H., Niederwieser, D., Fischer, T., Ehninger, G., Heuser, M., Ganser, A., Bullinger, L., Larson, R.A., Bloomfield, C.D., Stone, R.M., Döhner, H., Thiede, C. and Döhner, K.
Leukemia 36
(1): 90-99.
January 2022
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Bloehdorn, J., Braun, A., Taylor-Weiner, A., Jebaraj, B.M.C., Robrecht, S., Krzykalla, J., Pan, H., Giza, A., Akylzhanova, G., Holzmann, K., Scheffold, A., Johnston, H.E., Yeh, R.F., Klymenko, T., Tausch, E., Eichhorst, B., Bullinger, L., Fischer, K., Weisser, M., Robak, T., Schneider, C., Gribben, J., Dahal, L.N., Carter, M.J., Elemento, O., Landau, D.A., Neuberg, D.S., Cragg, M.S., Benner, A., Hallek, M., Wu, C.J., Döhner, H., Stilgenbauer, S. and Mertens, D.
Nature Communications 12
(1): 5395.
13 September 2021
Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.
Rapaport, F., Neelamraju, Y., Baslan, T., Hassane, D., Gruszczynska, A., de Massy, M.R., Farnoud, N., Haddox, S., Lee, T., Medina-Martinez, J., Sheridan, C., Thurmond, A., Becker, M., Bekiranov, S., Carroll, M., Moses Murdock, H., Valk, P.J.M., Bullinger, L., D’Andrea, R., Lowe, S.W., Neuberg, D., Levine, R.L., Melnick, A. and Garrett-Bakelman, F.E.
Leukemia 35
(9): 2688-2692.
September 2021
Genome sequencing in myeloid cancers.
Dolnik, A., Schrezenmeier, J. and Bullinger, L.
New England Journal of Medicine 384
(25): e106.
24 June 2021
Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.
Schmalbrock, L.K., Dolnik, A., Cocciardi, S., Sträng, E., Theis, F., Jahn, N., Panina, E., Blätte, T.J., Herzig, J.K., Skambraks, S., Rücker, F.G., Gaidzik, V.I., Paschka, P., Fiedler, W., Salih, H.R., Wulf, G.G., Schroeder, T., Lübbert, M., Schlenk, R.F., Thol, F., Heuser, M., Larson, R.A., Ganser, A., Stunnenberg, H.G., Minucci, S., Stone, R.M., Bloomfield, C.D., Döhner, H., Döhner, K. and Bullinger, L.
Blood 137
(22): 3093-3104.
3 June 2021
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K., Hablesreiter, R., Inoue, Y., Yoshida, K., Briest, F., Christen, F., Kakiuchi, N., Yoshizato, T., Shiozawa, Y., Shiraishi, Y., Striefler, J.K., Bischoff, S., Lohneis, P., Putter, H., Blau, O., Keilholz, U., Bullinger, L., Pelzer, U., Hummel, M., Riess, H., Ogawa, S., Sinn, M. and Damm, F.
EBioMedicine 66
: 103327.
April 2021
B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J., Michaelis, E., Greuel, S., Heynol, V., Lehmann, A., Radbruch, H., Meinhardt, J., Miller, F., Herbst, H., Corman, V.M., Westermann, J., Bullinger, L., Horst, D., von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103
: 628-635.
February 2021
Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.
Kapp-Schwoerer, S., Weber, D., Corbacioglu, A., Gaidzik, V.I., Paschka, P., Krönke, J., Theis, F., Rücker, F.G., Teleanu, M.V., Panina, E., Jahn, N., Herzig, J., Kubanek, L., Schrade, A., Göhring, G., Fiedler, W., Kindler, T, Schroeder, T., Mayer, K.T., Lübbert, M., Wattad, M., Götze, K.S., Horst, H.A., Koller, E., Wulf, G., Schleicher, J., Bentz, M., Krauter, J., Bullinger, L., Krzykalla, J., Benner, A., Schlenk, R.F., Thol, F., Heuser, M., Ganser, A., Döhner, H and Döhner, K.
Blood 136
(26): 3041-3050.
24 December 2020
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K., Schnöder, T.M., Perner, F., Herzog, C., Meiler, A., Krishnamoorthy, G., Huber, N., Mohr, J., Edelmann-Stephan, B., Austin, R., Brandt, S., Palandri, F., Schröder, N., Isermann, B., Edlich, F., Sinha, A.U., Ungelenk, M., Hübner, C.A., Zeiser, R., Rahmig, S., Waskow, C., Coldham, I., Ernst, T., Hochhaus, A., Jilg, S., Jost, P.J., Mullally, A., Bullinger, L., Mertens, P.R., Lane, S.W., Mann, M. and Heidel, F.H.
Nature 588
(7836): 157-163.
3 December 2020
Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O., Bullinger, L., Thiede, C., Flörcken, A., Westermann, J., Ehninger, G., Ho, A.D., Müller-Tidow, C., Gu, Z., Herrmann, C., Krijgsveld, J., Trumpp, A. and Hansson, J.
Blood 136
(13): 1507-1519.
24 September 2020
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf, R.Z., Saez, B., Sharda, A., van Gastel, N., Yu, V.W.C., Baryawno, N., Scadden, E.W., Acharya, S., Chattophadhyay, S., Huang, C., Viswanathan, V., S'aulis, D., Cobert, J., Sykes, D.B., Keibler, M.A., Das, S., Hutchinson, J.N., Churchill, M., Mukherjee, S., Lee, D., Mercier, F., Doench, J., Bullinger, L., Logan, D.J., Schreiber, S., Stephanopoulos, G., Rizzo, W.B. and Scadden, D.T.
Blood 136
(11): 1303-1316.
10 September 2020
Böttcher, Chotima (ECRC)
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J., Meinhardt, J., Aschman, T., Chua, R.L., Farztdinov, V., Lukassen, S., Ten, F.W., Friebel, E., Ishaque, N., Franz, J., Huhle, V.H., Mothes, R., Peters, K., Thomas, C., Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D., Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S., Horst, D., Kurth, F., Müller, M.A., Gassen, N.C., Melchert, J., Jechow, K., Timmermann, B., Fernandez-Zapata, C., Böttcher, C., Stenzel, W., Krüger, E., Landthaler, M., Wyler, E., Corman, V., Stadelmann, C., Ralser, M., Eils, R., Heppner, F.L., Mülleder, M., Conrad, C. and Radbruch, H.
Nature Neuroscience 27
(3): 409-420.
March 2024
Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
Letizia, M., Wang, Y.H., Kaufmann, U., Gerbeth, L., Sand, A., Brunkhorst, M., Weidner, P., Ziegler, J.F., Böttcher, C., Schlickeiser, S., Fernández, C., Yamashita, M., Stauderman, K., Sun, K., Kunkel, D., Prakriya, M., Sanders, A.D., Siegmund, B., Feske, S. and Weidinger, C.
EMBO Molecular Medicine 14
(9): e15687.
7 September 2022
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93
(9): 960-971.
September 2022
Calkhoven, Cornelis F.
Analysis of translation initiation using a translation control reporter system.
Wiesenthal, V., Leutz, A. and Calkhoven, C.F.
Nature Protocols 1
(3): 1531-1537.
9 November 2006
Cardoso, Cristina
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
Herce, H.D., Schumacher, D., Schneider, A.F.L., Ludwig, A.K., Mann, F.A., Fillies, M., Kasper, M.-A., Reinke, S., Krause, E., Leonhardt, H., Cardoso, M.C. and Hackenberger, C.P.R.
Nature Chemistry 9
(8): 762-771.
August 2017
Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L., Carlton, P.M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B., Cardoso, M.C., Agard, D.A., Gustafsson, M.G., Leonhardt, H. and Sedat, J.W.
Science 320
(5881): 1332-1336.
6 June 2008
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
von Vietinghoff, S., Tunnemann, G., Eulenberg, C., Wellner, M., Cardoso, M.C., Luft, F.C. and Kettritz, R.
Blood 109
(10): 4487-4493.
15 May 2007
Targeting and tracing antigens in live cells with fluorescent nanobodies.
Rothbauer, U., Zolghadr, K., Tillib, S., Nowak, D., Schermelleh, L., Gahl, A., Backmann, N., Conrath, K., Muyldermans, S., Cardoso, M.C. and Leonhardt, H.
Nature Methods 3
(11): 887-889.
November 2006
Recruitment of DNA methyltransferase I to DNA repair sites.
Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M.C. and Leonhardt, H.
Proceedings of the National Academy of Sciences of the United States of America 102
(25): 8905-8909.
21 June 2005
Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation.
Brero, A., Easwaran, H.P., Nowak, D., Grunewald, I., Cremer, T., Leonhardt, H. and Cardoso, M.C.
Journal of Cell Biology 169
(5): 733-743.
6 June 2005
Dynamic targeting of the replication machinery to sites of DNA damage.
Solomon, D.A., Cardoso, M.C. and Knudsen, E.S.
Journal of Cell Biology 166
(4): 455-463.
16 August 2004
Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M., Rolle, S., Wellner, M., Cardoso, M.C., Scheidereit, C., Luft, F.C. and Kettritz, R.
Blood 102
(6): 2259-2267.
15 September 2003
Chromosomal instability and tumors promoted by DNA hypomethylation.
Eden, A., Gaudet, F., Waghmare, A. and Jaenisch, R.
Science 300
(5618): 455-455.
18 April 2003
Induction of tumors in mice by genomic hypomethylation.
Gaudet, F., Hodgson, J.G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J.W., Leonhardt, H. and Jaenisch, R.
Science 300
(5618): 489-492.
18 April 2003
DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.
Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H. and Cardoso, M.C.
Molecular Cell 10
(6): 1355-1365.
December 2002
Dynamics of DNA replication factories in living cells.
Leonhardt, H., Rahn, H.P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D. and Cardoso, M.C.
Journal of Cell Biology 149
(2): 271-279.
17 April 2000
DNA methyltransferase is actively retained in the cytoplasm during early development.
Cardoso, M.C. and Leonhardt, H.
Journal of Cell Biology 147
(1): 25-32.
4 October 1999
Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo.
Cardoso, M.C., Joseph, C., Rahn, H.P., Reusch, R., Nadal-Ginard, B. and Leonhardt, H.
Journal of Cell Biology 139
: 579-587.
1 January 1997
Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.
Tucker, K.L., Talbot, D., Lee, M.A., Leonhardt, H. and Jaenisch, R.
Proceedings of the National Academy of Sciences of the United States of America 93
(23): 12920-12925.
12 November 1996
Chekulaeva, Marina (BIMSB)
Mechanistic insights into the basis of widespread RNA localization.
Chekulaeva, M.
Nature Cell Biology 26
(7): 1037-1046.
July 2024
mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons.
Loedige, I., Baranovskii, A., Mendonsa, S., Dantsuji, S., Popitsch, N., Breimann, L., Zerna, N., Cherepanov, V., Milek, M., Ameres, S. and Chekulaeva, M.
Molecular Cell 83
(15): 2709-2725.
3 August 2023
First demonstration of miRNA-dependent mRNA decay.
Chekulaeva, M.
Nature Reviews Molecular Cell Biology 24
(3): 164.
March 2023
Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S., von Kügelgen, N., Dantsuji, S., Ron, M., Breimann, L., Baranovskii, A., Lödige, I., Kirchner, M., Fischer, M., Zerna, N., Bujanic, L., Mertins, P., Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26
(3): 394-405.
March 2023
Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J., Baranovskii, A., Ronen, J., Uyar, B., Franke, V. and Akalin, A.
Genome Biology 23
(1): 123.
30 May 2022
Novel targets, treatments, and advanced models for intracerebral haemorrhage.
Zille, M., Farr, T.D., Keep, R.F., Römer, C., Xi, G. and Boltze, J.
EBioMedicine 76
: 103880.
12 February 2022
Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response.
Mendonsa, S., von Kuegelgen, N., Bujanic, L. and Chekulaeva, M.
Nucleic Acids Research 49
(17): 10007-10017.
27 September 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Witte, F., Ruiz-Orera, J., Ciolli Mattioli, C., Blachut, S., Adami, E., Schulz, J.F., Schneider-Lunitz, V., Hummel, O., Patone, G., Mücke, M.B., Šilhavý, Jan, Heinig, M., Bottolo, L., Sanchis, D., Vingron, M., Chekulaeva, M., Pravenec, M., Hubner, N. and van Heesch, S.
Genome Biology 22
(1): 191.
28 June 2021
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
Translation of circRNAs.
Pamudurti, N.R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., Shenzis, S., Samson, M., Dittmar, G., Landthaler, M., Chekulaeva, M., Rajewsky, N. and Kadener, S.
Molecular Cell 66
(1): 9-21.
6 April 2017
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M., Kirchner, M., Aharoni, R., Ciolli Mattioli, C., van den Bruck, D., Gutkovitch, N., Modepalli, V., Selbach, M., Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45
(2): 938-950.
25 January 2017
Eyes on translation.
Chekulaeva, M. and Landthaler, M.
Molecular Cell 63
(6): 918-925.
15 September 2016
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Libri, V., Yandim, C., Athanasopoulos, S., Loyse, N., Natisvili, T., Law, P.P., Chan, P.K., Mohammad, T., Mauri, M., Tam, K.T., Leiper, J., Piper, S., Ramesh, A., Parkinson, M.H., Huson, L., Giunti, P. and Festenstein, R.
Lancet 384
(9942): 504-513.
9 August 2014
Chen, Wei (BIMSB/BIH)
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M., Valasarajan, C., Werner, A., Boeckel, J.N., Bischoff, F.C., John, D., Weirick, T., Glaser, S.F., Rossbach, O., Jaé, N., Demolli, S., Khassafi, F., Yuan, K., de Jesus Perez, V.A., Michalik, K.M., Chen, W., Seeger, W., Guenther, A., Wasnick, R.M., Uchida, S., Zeiher, A.M., Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202
(10): 1445-1457.
15 November 2020
FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L., Liang, H., Zhang, H., Yang, M.Z., Sun, W., Zhang, P., Luo, L., Feng, J.X., Bai, H., Liu, F., Zhang, T., Yang, J.Y., Gao, Q., Long, Y., Ma, X.Y., Chen, Y., Zhong, Q., Yu, B., Liao, S., Wang, Y., Zhao, Y., Zeng, M.S., Cao, N., Wang, J., Chen, W., Yang, H.T. and Gao, S.
Nucleic Acids Research 48
(5): 2733-2748.
18 March 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11
(1): 929.
17 February 2020
The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B., Wang, X., Eichelbaum, K., Sadewasser, A., Husic, I., Paki, K., Budt, M., Hergeselle, M., Vetter, B., Hou, J., Chen, W., Wiebusch, L., Meyer, I.M., Wolff, T. and Selbach, M.
Nature Communications 10
(1): 5518.
4 December 2019
Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X., You, X., Langer, J.D., Hou, J., Rupprecht, F., Vlatkovic, I., Quedenau, C., Tushev, G., Epstein, I., Schaefke, B., Sun, W., Fang, L., Li, G., Hu, Y., Schuman, E.M. and Chen, W.
Nature Communications 10
(1): 5009.
1 November 2019
Genetics of intellectual disability in consanguineous families.
Hu, H., Kahrizi, K., Musante, L., Fattahi, Z., Herwig, R., Hosseini, M., Oppitz, C., Abedini, S.S., Suckow, V., Larti, F., Beheshtian, M., Lipkowitz, B., Akhtarkhavari, T., Mehvari, S., Otto, S., Mohseni, M., Arzhangi, S., Jamali, P., Mojahedi, F., Taghdiri, M., Papari, E., Soltani Banavandi, M.J., Akbari, S., Tonekaboni, S.H., Dehghani, H., Ebrahimpour, M.R., Bader, I., Davarnia, B., Cohen, M., Khodaei, H., Albrecht, B., Azimi, S., Zirn, B., Bastami, M., Wieczorek, D., Bahrami, G., Keleman, K., Vahid, L.N., Tzschach, A., Gärtner, J., Gillessen-Kaesbach, G., Varaghchi, J.R., Timmermann, B., Pourfatemi, F., Jankhah, A., Chen, W., Nikuei, P., Kalscheuer, V.M., Oladnabi, M., Wienker, T.F., Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 24
(7): 1027-1039.
July 2019
The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37
(24): e98658.
14 December 2018
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y., Deng, X.Y., Li, Y.S., Ma, X.C., Feng, J.X., Yu, B., Chen, Y., Luo, Y.L., Wang, X., Chen, M.L., Fang, Z.X., Zheng, F.X., Li, Y.P., Zhong, Q., Kang, T.B., Song, L.B., Xu, R.H., Zeng, M.S., Chen, W., Zhang, H., Xie, W. and Gao, S.
Nature Communications 9
(1): 1165.
21 March 2018
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W., Feyerabend, T.B., Rössler, J., Wang, X., Postrach, D., Busch, K., Rode, I., Klapproth, K., Dietlein, N., Quedenau, C., Chen, W., Sauer, S., Wolf, S., Höfer, T. and Rodewald, H.Re.
Nature 548
(7668): 456-460.
24 August 2017
Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C., Werner, A., John, D., Boeckel, J.-N., Melissari, M.-T., Grote, P., Glaser, S.F., Demolli, S., Uchida, S., Michalik, K.M., Meder, B., Katus, H.A., Haas, J., Chen, W., Pullamsetti, S.S., Seeger, W., Zeiher, A.M., Dimmeler, S. and Zehendner, C.M.
Circulation Research 121
(4): 368-375.
4 August 2017
Identification of the elementary structural units of the DNA damage response.
Natale, F., Rapp, A., Yu, W., Maiser, A., Harz, H., Scholl, A., Grulich, S., Anton, T., Hoerl, D., Chen, W., Durante, M., Taucher-Scholz, G., Leonhardt, H. and Cardoso, M.C.
Nature Communications 8
: 15760.
12 June 2017
Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F., Kuehnen, P., Suntharalingham, J.P., Del Valle, I., Digweed, M., Stachelscheid, H., Khajavi, N., Didi, M., Brady, A.F., Blankenstein, O., Procter, A.M., Dimitri, P., Wales, J.K.H., Ghirri, P., Knoebl, D., Strahm, B., Erlacher, M., Wlodarski, M.W., Chen, W., Kokai, G.K., Anderson, G., Morrogh, D., Moulding, D.A., McKee, S. A., Niemeyer, C.M., Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127
(5): 1700-1713.
1 May 2017
Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F., Gasparoni, N., Gasparoni, G., Gianmoena, K., Cadenas, C., Polansky, J.K., Ebert, P., Nordstroem, K., Barann, M., Sinha, A., Froehler, S., Xiong, J., Dehghani Amirabad, A., Behjati Ardakani, F., Hutter, B., Zipprich, G., Felder, B., Eils, J., Brors, B., Chen, W., Hengstler, J.G., Hamann, A., Lengauer, T., Rosenstiel, P., Walter, J. and Schulz, M.H.
Nucleic Acids Research 45
(1): 54-66.
9 January 2017
Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glažar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A.., Ardakani, F.B., Feuerbach, L., Gorka, O., Ebert, P., Müller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Fröhler, S., Felder, B., Gasparoni, N., Imbusch, C.D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A.S., Sieverling, L., Chang, H.D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.R., Rosenstiel, P., Schulz, M.H., Schultze, J.L., Radbruch, A., Walter, J., Hamann, A. and Polansky, J.K.
Immunity 45
(5): 1148-1161.
15 November 2016
Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E., Sin, C., Zauber, H., Wells, J.N., Donnelly, N., Wang, X., Hou, J., Chen, W., Storchova, Z., Marsh, J.A., Valleriani, A. and Selbach, M.
Cell 167
(3): 803-815.
20 October 2016
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos, K., Gatsiou, A., Stamatelopoulos, K., Perisic Matic, L., John, D., Lunella, F.F., Jae, N., Rossbach, O., Amrhein, C., Sigala, F., Boon, R.A., Fuertig, B., Manavski, Y., You, X., Uchida, S., Keller, T., Boeckel, J.N., Franco-Cereceda, A., Maegdefessel, L., Chen, W., Schwalbe, H., Bindereif, A., Eriksson, P., Hedin, U., Zeiher, A.M. and Dimmeler, S.
Nature Medicine 22
(10): 1140-1150.
October 2016
Circular RNAs in brain and other tissues: a functional enigma.
Chen, W. and Schuman, E.
Trends in Neurosciences 39
(9): 597-604.
September 2016
reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S., Helmuth, J., Polansky, J.K., Dunkel, I., Gasparoni, G., Froehler, S., Chen, W., Walter, J., Hamann, A. and Chung, H.R.
Nature Communications 7
: 12514.
17 August 2016
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H., Haas, S.A., Chelly, J., Van Esch, H., Raynaud, M., de Brouwer, A.P.M., Weinert, S., Froyen, G., Frints, S.G.M., Laumonnier, F., Zemojtel, T., Love, M.I., Richard, H., Emde, A.K., Bienek, M., Jensen, C., Hambrock, M., Fischer, U., Langnick, C., Feldkamp, M., Wissink-Lindhout, W., Lebrun, N., Castelnau, L., Rucci, J., Montjean, R., Dorseuil, O., Billuart, P., Stuhlmann, T., Shaw, M., Corbett, M.A., Gardner, A., Willis-Owen, S., Tan, C., Friend, K.L., Belet, S., van Roozendaal, K.E.P., Jimenez-Pocquet, M., Moizard, M.P., Ronce, N., Sun, R., O'Keeffe, S., Chenna, R., van Bömmel, A., Goeke, J., Hackett, A., Field, M., Christie, L., Boyle, J., Haan, E., Nelson, J., Turner, G., Baynam, G., Gillessen-Kaesbach, G., Mueller, U., Steinberger, D., Budny, B., Badura-Stronka, M., Latos-Bieleńska, A., Ousager, L.B., Wieacker, P., Rodríguez Criado, G., Bondeson, M.L., Annerén, G., Dufke, A., Cohen, M., Van Maldergem, L., Vincent-Delorme, C., Echenne, B., Simon-Bouy, B., Kleefstra, T., Willemsen, M., Fryns, J.P., Devriendt, K., Ullmann, R., Vingron, M., Wrogemann, K., Wienker, T.F., Tzschach, A., van Bokhoven, H., Gecz, J., Jentsch, T.J., Chen, W., Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21
(1): 133-148.
January 2016
Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N., Jae, N., Heumueller, A.W., Chen, W., Boon, R.A., Stellos, K., Zeiher, A.M., John, D., Uchida, S. and Dimmeler, S.
Circulation Research 117
(10): 884-890.
23 October 2015
Extensive allele-specific translational regulation in hybrid mice.
Hou, J., Wang, X., McShane, E., Zauber, H., Sun, W., Selbach, M. and Chen, W.
Molecular Systems Biology 11
(8): 825.
7 August 2015
Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao, Q., Sun, W., Ballegeer, M., Libert, C. and Chen, W.
Molecular Systems Biology 11
(7): 816.
1 July 2015
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., Wang, X., Hou, J., Liu, H., Sun, W., Sambandan, S., Chen, T., Schuman, E.M. and Chen, W.
Nature Neuroscience 18
(4): 603-610.
April 2015
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
Natural variation of histone modification and its impact on gene expression in the rat genome.
Rintisch, C., Heinig, M., Bauerfeind, A., Schafer, S., Mieth, C., Patone, G., Hummel, O., Chen, W., Cook, S., Cuppen, E., Colomé-Tatché, M., Johannes, F., Jansen, R.C., Neil, H., Werner, M., Pravenec, M., Vingron, M. and Hubner, N.
Genome Research 24
(6): 942-953.
June 2014
MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H., Schueler, M., Munschauer, M., Mastrobuoni, G., Chen, W., Kempa, S., Dieterich, C. and Landthaler, M.
Molecular Cell 54
(4): 573-585.
22 May 2014
Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
Michalik, K.M., You, X., Manavski, Y., Doddaballapur, A., Zoernig, M., Braun, T., John, D., Ponomareva, Y., Chen, W., Uchida, S., Boon, R.A. and Dimmeler, S.
Circulation Research 114
(9): 1389-1397.
25 April 2014
Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M., Munschauer, M., Gregersen, L.H., Finzel, A., Loewer, A., Chen, W., Landthaler, M. and Dieterich, C.
Genome Biology 15
(1): R15.
13 January 2014
Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Tattikota, S.G., Rathjen, T., McAnulty, S.J., Wessels, H.H., Akerman, I., van de Bunt, M., Hausser, J., Esguerra, J.L.S., Musahl, A., Pandey, A.K., You, X., Chen, W., Herrera, P.L., Johnson, P.R., O'Carroll, D., Eliasson, L., Zavolan, M., Gloyn, A.L., Ferrer, J., Shalom-Feuerstein, R., Aberdam, D. and Poy, M.N.
Cell Metabolism 19
(1): 122-134.
7 January 2014
Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E., Mah, N., Naumann, H., Pongrac, I.M., Cerdá-Esteban, N., Fontaine, J.F., Wang, Y., Chen, W., Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27
(17): 1932-1946.
1 September 2013
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur, S.S., Diaz, A.G., Maratou, K., Sarkis, A., Rotival, M., Game, L., Tschannen, M.R., Kaisaki, P.J., Otto, G.W., John Ma, M.C., Keane, T.M., Hummel, O., Saar, K., Chen, W., Guryev, V., Gopalakrishnan, K., Garrett, M.R., Joe, B., Citterio, L., Bianchi, G., McBride, M., Dominiczak, A., Adams, D.J., Serikawa, T., Flicek, P., Cuppen, E., Hubner, N., Petretto, E., Gauguier, D., Kwitek, A., Jacob, H. and Aitman, T.J.
Cell 154
(3): 691-703.
1 August 2013
Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun, W., You, X., Gogol-Doering, A., He, H., Kise, Y., Sohn, M., Chen, T., Klebes, A., Schmucker, D. and Chen, W.
EMBO Journal 32
(14): 2029-2038.
17 July 2013
Widespread splicing changes in human brain development and aging.
Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Chen, Y.P.P., Li, N., Hu, Y., Fu, N., Ning, Z., Zeng, R., Yang, H., Chen, W., Gelfand, M. and Khaitovich, P.
Molecular Systems Biology 9
: 633.
2013
Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat, S., Schmidt, A., Codlin, S., Chen, W., Aebersold, R. and Baehler, J.
Cell 151
(3): 671-683.
26 October 2012
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo, S., Yuan, Y.P., He, L., Oleksiak, A., Zhang, Y., Li, N., Hu, Y., Chen, W., Qiu, Z., Paeaebo, S. and Khaitovich, P.
Genome Research 22
(4): 611-622.
April 2012
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
Somel, M., Liu, X., Tang, L., Yan, Z., Hu, H., Guo, S., Jiang, X., Zhang, X., Xu, G., Xie, G., Li, N., Hu, Y., Chen, W., Paeaebo, S. and Khaitovich, P.
PLoS Biology 9
(12): e1001214.
December 2011
Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Najmabadi, H., Hu, H., Garshasbi, M., Zemojtel, T., Abedini, S.S., Chen, W., Hosseini, M., Behjati, F., Haas, S., Jamali, P., Zecha, A., Mohseni, M., Puettmann, L., Vahid, L.N., Jensen, C., Moheb, L.A., Bienek, M., Larti, F., Mueller, I., Weissmann, R., Darvish, H., Wrogemann, K., Hadavi, V., Lipkowitz, B., Esmaeeli-Nieh, S., Wieczorek, D., Kariminejad, R., Firouzabadi, S.G., Cohen, M., Fattahi, Z., Rost, I., Mojahedi, F., Hertzberg, C., Dehghan, A., Rajab, A., Banavandi, M.J.S., Hoffer, J., Falah, M., Musante, L., Kalscheuer, V., Ullmann, R., Kuss, A.W., Tzschach, A., Kahrizi, K. and Ropers, H.H.
Nature 478
(7367): 57-63.
6 October 2011
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C., Wang, Y., Gruen, D., Mastrobuoni, G., You, X., Tolle, D., Dodt, M., Mackowiak, S.D., Gogol-Doering, A., Oenal, P., Rybak, A., Ross, E., Alvarado, A.S., Kempa, S., Dieterich, C., Rajewsky, N. and Chen, W.
Genome Research 21
(7): 1193-1200.
July 2011
Global quantification of mammalian gene expression control.
Schwanhaeusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W. and Selbach, M.
Nature 473
(7347): 337-342.
19 May 2011
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B., Haftmann, C., Sgouroudis, E., Kuehl, A.A., Hegazy, A.N., Panse, I., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G.A., Fang, Z., Li, N., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F.M., Baumgrass, R., Bosio, A., Mollenkopf, H.J., Gruen, J., Thiel, A., Chen, W., Hoefer, T., Loddenkemper, C., Loehning, M., Chang, H.D., Rajewsky, N., Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11
(11): 1057-1062.
November 2010
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
Somel, M., Guo, S., Fu, N., Yan, Z., Hu, H.Y., Xu, Y., Yuan, Y., Ning, Z., Hu, Y., Menzel, C., Hu, H., Lachmann, M., Zeng, R., Chen, W. and Khaitovich, P.
Genome Research 20
(9): 1207-1218.
September 2010
Altered histone acetylation is associated with age-dependent memory impairment in mice.
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R.C., Cota, P., Wittnam, J.L., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhofer, M., Kang, H., Farinelli, L., Chen, W. and Fischer, A.
Science 328
(5979): 753-756.
7 May 2010
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius, M., Maaskola, J., Colombo, T., Rahn, H.P., Friedlaender, M.R., Li, N., Chen, W., Piano, F. and Rajewsky, N.
Nature Methods 6
(10): 745-751.
October 2009
A human snoRNA with microRNA-like functions.
Ender, C., Krek, A., Friedlaender, M.R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N. and Meister, G.
Molecular Cell 32
(4): 519-528.
21 November 2008
Discovering microRNAs from deep sequencing data using miRDeep.
Friedlaender, M.R., Chen, W., Adamidi, C., Maaskola, J., Einspanier, R., Knespel, S. and Rajewsky, N.
Nature Biotechnology 26
(4): 407-415.
April 2008
Coscia, Fabian
Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
Bech, J.M., Terkelsen, T., Bartels, A.S., Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G.I., Fang, X., Mann, M. and Moreira, J.M.A.
Gastroenterology 165
(1): 121-132.e5.
July 2023
The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G., Vanzo, R., Amitash, S., Martín-Doncel, E., Coscia, F., Mund, A., Lerdrup, M., Benada, J., Boos, D. and Toledo, L.
Molecular Cell 82
(18): 3350-3365.
15 September 2022
Deep Visual Proteomics defines single-cell identity and heterogeneity.
Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A.D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L.M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M.A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. and Mann, M.
Nature Biotechnology 40
(8): 1231-1240.
August 2022
Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M., Schaupp, A.L., Sun, R., Coscia, F., Dendrou, C.A., Cortes, A., Kaur, G., Evans, H.G., Mollbrink, A., Navarro, J.F., Sonner, J.K., Mayer, C., DeLuca, G.C., Lundeberg, J., Matthews, P.M., Attfield, K.E., Friese, M.A., Mann, M. and Fugger, L.
Nature Neuroscience 25
(7): 944-955.
July 2022
Daniel, Peter
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders, K., Buschow, C., Herrmann, A., Milojkovic, A., Loddenkemper, C., Kammertoens, T., Daniel, P., Yu, H., Charo, J. and Blankenstein, T.
Cancer Cell 20
(6): 755-767.
13 December 2011
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.
Zaltsman, Y., Shachnai, L., Yivgi-Ohana, N., Schwarz, M., Maryanovich, M., Houtkooper, R.H., Vaz, F.M., De Leonardis, F., Fiermonte, G., Palmieri, F., Gillissen, B., Daniel, P.T., Jimenez, E., Walsh, S., Koehler, C.M., Roy, S.S., Walter, L., Hajnoczky, G. and Gross, A.
Nature Cell Biology 12
(6): 553-562.
June 2010
Apoptolidin: Induction of apoptosis by a natural product.
Daniel, P.T., Koert, U. and Schuppan, J.
Angewandte Chemie International Edition 45
: 872-893.
30 January 2006
Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R.A., Daniel, P.T., Bommert, K., Vassilev, L.T. and Bargou, R.C.
Blood 106
: 3609-3617.
4 August 2005
Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B., Sturm, I., Lage, H., Berger, S., Schneider, U., Haupfmann, S., Wust, P., Riess, H., Schlag, P.M., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21
(18): 3391-3401.
15 September 2003
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B., Essmann, F., Graupner, V., Staerck, L., Radetzki, S., Doerken, B., Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22
(14): 3580-3590.
15 July 2003
Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in scid mice.
Bargou, R.C., Wagener, C., Bommert, K., Arnold, W., Daniel, P.T., Mapara, M.Y., Grinstein, E., Royer, H.D. and Doerken, B.
Journal of Experimental Medicine 183
(3): 1205-1213.
1 March 1996
Daumke, Oliver
Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15
(1): 3146.
11 April 2024
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y., Leney-Greene, M., Lynberg, M., Gabrielski, J.Q., Xu, X., Schwarz, B., Zheng, L., Balasubramaniyam, A., Ham, H., Chao, B., Zhang, Y., Matthews, H.F., Cui, J., Yao, Y., Kubo, S., Chanchu, J.M., Morawski, A.R., Cook, S.A., Jiang, P., Ravell, J.C., Cheng, Y.H., George, A., Faruqi, A., Pagalilauan, A.M., Bergerson, J.R.E., Ganesan, S., Chauvin, S.D., Aluri, J., Edwards-Hicks, J., Bohrnsen, E., Tippett, C., Omar, H., Xu, L., Butcher, G.W., Pascall, J., Karakoc-Aydiner, E., Kiykim, A., Maecker, H., Tezcan, İ., Esenboga, S., Heredia, R.J., Akata, D., Tekin, S., Kara, A., Kuloglu, Z., Unal, E., Kendirli, T., Dogu, F., Karabiber, E., Atkinson, T.P., Cochet, C., Filhol, O., Bosio, C.M., Davis, M.M., Lifton, R.P., Pearce, E.L., Daumke, O., Aytekin, C., Şahin, G.E., Aksu, A.Ü., Uzel, G., Koneti Rao, V., Sari, S., Boztug, K., Cagdas, D., Haskologlu, S., Ikinciogullari, A., Schwefel, D., Vilarinho, S., Baris, S., Ozen, A., Su, H.C. and Lenardo, M.J.
Nature Immunology 25
(2): 282-293.
February 2024
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske, Y., Cappel, C., Cremer, N., Hoffmann, P., Koudelka, T., Tholey, A., Heinemann, U., Daumke, O. and Damme, M.
Nucleic Acids Research 52
(1): 370-384.
11 January 2024
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14
(1): 6947.
7 November 2023
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T., Stolzenberg, S., Sticht, J., Wieczorek, M., Roske, Y., Günther, M., Dähn, S., Boesen, B.B., Calvo, M.M., Biese, C., Kuppler, F., Medina-García, Á., Álvaro-Benito, M., Höfer, T., Noé, F. and Freund, C.
Nature Chemical Biology 19
(10): 1196-1204.
October 2023
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N., Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A., André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M., Cui, C., Daumke, O., Del Bel, K.L., Eibel, H., Feng, X., Franke, V., Gebhardt, J.C.M., Götz, A., Grunwald, S., Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M., Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W., Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S., Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8
(79): eade7953.
January 2023
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T., Belabed, H., Kücükdisli, M., Metag, J., Roske, Y., Prokofeva, P., Ohashi, Y., Horatscheck, A., Cirillo, D., Krauss, M., Schmied, C., Neuenschwander, M., von Kries, J.P., Médard, G., Kuster, Be., Perisic, O., Williams, R.L., Daumke, O., Payrastre, B., Severin, S., Nazaré, M. and Haucke, V.
Nature Chemical Biology 19
(1): 18-27.
January 2023
Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A., Sprink, T., Noel, J.K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C.M.T. and Daumke, O.
Nature Communications 13
(1): 7641.
10 December 2022
Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. and Daumke, O.
Science Advances 8
(35): eabo4946.
2 September 2022
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y., Du Jiang, P., Chao, B.N., Cagdas, D., Kubo, S., Balasubramaniyam, A., Zhang, Y., Shadur, B., NaserEddin, A., Folio, L.R., Schwarz, B., Bohrnsen, E., Zheng, L., Lynberg, M., Gottlieb, S., Leney-Greene, M.A., Park, A.Y., Tezcan, I., Akdogan, A., Gocmen, R., Onder, S., Rosenberg, A., Soilleux, E.J., Johnson, E., Jackson, P.K., Demeter, J., Chauvin, S.D., Paul, F., Selbach, M., Bulut, H., Clatworthy, M.R., Tuong, Z.K., Zhang, H., Stewart, B.J., Bosio, C.M., Stepensky, P., Clare, S., Ganesan, S., Pascall, J.C., Daumke, O., Butcher, G.W., McMichael, A.J., Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219
(6): e20201405.
6 June 2022
Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T., Zhang, Y., Vadas, O., Roske, Y., Gulluni, F., De Santis, M.C., Zagar, A.V., Stephanowitz, H., Hirsch, E., Liu, F., Daumke, O., Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29
(3): 218-228.
March 2022
SPFH protein cage - one ring to rule them all.
Daumke, O. and Lewin, G.R.
Cell Research 32
(2): 117-118.
February 2022
Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K., Teranishi, K., Ambroso, M.R., Isas, J.M., Vazquez-Sarandeses, E., Lee, J.Y., Melo, A.A., Pandey, P., Merken, D., Berndt, L., Lammers, M., Daumke, O., Chang, K., Haworth, I.S. and Langen, R.
Nature Communications 12
(1): 6466.
9 November 2021
A simple pressure-assisted method for MicroED specimen preparation.
Zhao, J., Xu, H., Lebrette, H., Carroni, M., Taberman, H., Högbom, M. and Zou, X.
Nature Communications 12
(1): 5036.
19 August 2021
Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M., Vancraenenbroeck, R., Rosenblum, G., Hofmann, H., Mikhailov, A.S., Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118
(28): e2101144118.
13 July 2021
Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.
Liu, J., Tassinari, M., Souza, D.P., Naskar, S., Noel, J.K., Bohuszewicz, O., Buck, M., Williams, T.A., Baum, B. and Low, H.H.
Cell 184
(14): 3660-3673.
8 July 2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M.H., Abudu, Y.P., Acevedo-Arozena, A., Adamopoulos, I.E., Adeli, K., Adolph, T.E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B.B., Agnello, M., Agostinis, P., Agrewala, J.N., Agrotis, A., Aguilar, P.V., Ahmad, S.T., Ahmed, Z.M., Ahumada-Castro, U., Aits, S., Aizawa, S., Akkoc, Y., Akoumianaki, T., Akpinar, H.A., Al-Abd, A.M., Al-Akra, L., Al-Gharaibeh, A., Alaoui-Jamali, M.A., Alberti, S., Alcocer-Gómez, E., Alessandri, C., Ali, M., Alim Al-Bari, M.A., Aliwaini, S., Alizadeh, J., Almacellas, E., Almasan, A., Alonso, A., Alonso, G.D., Altan-Bonnet, N., Altieri, D.C., Álvarez, E.M.C., Alves, S., Alves da Costa, C., Alzaharna, M.M., Amadio, M., Amantini, C., Amaral, C., Ambrosio, S., Amer, A.O., Ammanathan, V., An, Z., Andersen, S.U., Andrabi, S.A., Andrade-Silva, M., Andres, A.M., Angelini, S., Ann, D., Anozie, U.C., Ansari, M.Y., Antas, P., Antebi, A., Antón, Z., Anwar, T., Apetoh, L., Apostolova, N., Araki, T., Araki, Y., Arasaki, K., Araújo, W.L., Araya, J., Arden, C., Arévalo, M.A., Arguelles, S., Arias, E., Arikkath, J., Arimoto, H., Ariosa, A.R., Armstrong-James, D., Arnauné-Pelloquin, L., Aroca, A., Arroyo, D.S., Arsov, I., Artero, R., Asaro, D.M.L., Aschner, M., Ashrafizadeh, M., Ashur-Fabian, O., Atanasov, A.G., Au, A.K., Auberger, P., Auner, H.W., Aurelian, L., Autelli, R., Avagliano, L., Ávalos, Y., Aveic, S., Aveleira, C.A., Avin-Wittenberg, T., Aydin, Y., Ayton, S., Ayyadevara, S., Azzopardi, M., Baba, M.u, Backer, J.M., Backues, S.K., Bae, D.H., Bae, O.N., Bae, S.H., Baehrecke, E.H., Baek, A., Baek, S.H., Baek, S.H., Bagetta, G., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, X., Bai, Y., Bairagi, N., Baksi, S., Balbi, T., Baldari, C.T., Balduini, W., Ballabio, A., Ballester, M., Balazadeh, S., Balzan, R., Bandopadhyay, R., Banerjee, S., Banerjee, S., Bánréti, A., Bao, Y., Baptista, M.S., Baracca, A., Barbati, C., Bargiela, A., Barilà, D., Barlow, P.G., Barmada, S.J., Barreiro, E., Barreto, G.E., Bartek, J., Bartel, B., Bartolome, A., Barve, G.R., Basagoudanavar, S.H., Bassham, D.C., Bast, R.C., Basu, A., Batoko, H., Batten, I., Baulieu, E.E., Baumgarner, B.L., Bayry, J., Beale, R., Beau, I., Beaumatin, F., Bechara, L.R.G., Beck, G.R., Beers, M.F., Begun, J., Behrends, C., Behrens, G.M.N., Bei, R., Bejarano, E., Bel, S., Behl, C., Belaid, A., Belgareh-Touzé, N., Bellarosa, C., Belleudi, F., Belló Pérez, M., Bello-Morales, R., Beltran, J.S.O., Beltran, S., Benbrook, D.M., Bendorius, M., Benitez, B.A., Benito-Cuesta, I., Bensalem, J., Berchtold, M.W., Berezowska, S., Bergamaschi, D., Bergami, M., Bergmann, A., Berliocchi, L., Berlioz-Torrent, C., Bernard, A., Berthoux, L., Besirli, C.G., Besteiro, S., Betin, V.M., Beyaert, R., Bezbradica, J.S., Bhaskar, K., Bhatia-Kissova, I., Bhattacharya, R., Bhattacharya, S., Bhattacharyya, S., Bhuiyan, M.S., Bhutia, S.K., Bi, L., Bi, X., Biden, T.J., Bijian, K., Billes, V.A., Binart, N., Bincoletto, C., Birgisdottir, A.B., Bjorkoy, G., Blanco, G., Blas-Garcia, A., Blasiak, J., Blomgran, R., Blomgren, K., Blum, J.S., Boada-Romero, E., Boban, M., Boesze-Battaglia, K., Boeuf, P., Boland, B., Bomont, P., Bonaldo, P., Bonam, S.R., Bonfili, L., Bonifacino, J.S., Boone, B.A., Bootman, M.D., Bordi, M., Borner, C., Bornhauser, B.C., Borthakur, G., Bosch, J., Bose, S., Botana, L.M., Botas, J., Boulanger, C.M., Boulton, M.E., Bourdenx, M., Bourgeois, B., Bourke, N.M., Bousquet, G., Boya, P., Bozhkov, P.V., Bozi, L.H.M., Bozkurt, T.O., Brackney, D.E., Brandts, C.H., Braun, R.J., Braus, G.H., Bravo-Sagua, R., Bravo-San Pedro, J.M., Brest, P., Bringer, M.A., Briones-Herrera, A., Broaddus, V.C., Brodersen, P., Brodsky, J.L., Brody, S.L., Bronson, P.G., Bronstein, J.M., Brown, C.N., Brown, R.E., Brum, P.C., Brumell, J.H., Brunetti-Pierri, N., Bruno, D., Bryson-Richardson, R.J., Bucci, C., Buchrieser, C., Bueno, M., Buitrago-Molina, L.E., Buraschi, S., Buch, S., Buchan, J.R., Buckingham, E.M., Budak, H., Budini, M., Bultynck, G., Burada, F., Burgoyne, J.R., Burón, M.I., Bustos, V., Büttner, S., Butturini, E., Byrd, A., Cabas, I., Cabrera-Benitez, S., Cadwell, K., Cai, J., Cai, L., Cai, Q., Cairó, M., Calbet, J.A., Caldwell, G.A., Caldwell, K.A., Call, J.A., Calvani, R., Calvo, A.C., Calvo-Rubio Barrera, M., Camara, N.O., Camonis, J.H., Camougrand, N., Campanella, M., Campbell, E.M., Campbell-Valois, F.X., Campello, S., Campesi, I., Campos, J.C., Camuzard, O., Cancino, J., Candido de Almeida, D., Canesi, L., Caniggia, I., Canonico, B., Cantí, C., Cao, B., Caraglia, M., Caramés, B., Carchman, E.H., Cardenal-Muñoz, E., Cardenas, C., Cardenas, L., Cardoso, S.M., Carew, J.S., Carle, G.F., Carleton, G., Carloni, S., Carmona-Gutierrez, D., Carneiro, L.A., Carnevali, O., Carosi, J.M., Carra, S., Carrier, A., Carrier, L., Carroll, B., Carter, A.B., Carvalho, A.N., Casanova, M., Casas, C., Casas, J., Cassioli, C., Castillo, E.F., Castillo, K., Castillo-Lluva, S., Castoldi, F., Castori, M., Castro, A.F., Castro-Caldas, M., Castro-Hernandez, J., Castro-Obregon, S., Catz, S.D., Cavadas, C., Cavaliere, F., Cavallini, G., Cavinato, M., Cayuela, M.L., Cebollada Rica, P., Cecarini, V., Cecconi, F., Cechowska-Pasko, M., Cenci, S., Ceperuelo-Mallafré, V., Cerqueira, J.J., Cerutti, J.M., Cervia, D., Cetintas, V.B., Cetrullo, S., Chae, H.J., Chagin, A.S., Chai, C.Y., Chakrabarti, G., Chakrabarti, O., Chakraborty, T., Chakraborty, T., Chami, M., Chamilos, G., Chan, D.W., Chan, E.Y.W., Chan, E.D., Chan, H.Y.E., Chan, H.H., Chan, H., Chan, M.T.V., Chan, Y.S., Chandra, P.K., Chang, C.P., Chang, C., Chang, H.C., Chang, K., Chao, J., Chapman, T., Charlet-Berguerand, N., Chatterjee, S., Chaube, S.K., Chaudhary, A., Chauhan, S., Chaum, E., Checler, F., Cheetham, M.E., Chen, C.S., Chen, G.C., Chen, J.F., Chen, L.L., Chen, L., Chen, L., Chen, M., Chen, M.K., Chen, N., Chen, Q., Chen, R.H., Chen, S., Chen, W., Chen, W., Chen, X.M., Chen, X.W., Chen, X., Chen, Y., Chen, Y.G., Chen, Y., Chen, Y., Chen, Y.J., Chen, Y.Q., Chen, Z.S., Chen, Z., Chen, Z.H., Chen, Z.J., Chen, Z., Cheng, H., Cheng, J., Cheng, S.Y., Cheng, W., Cheng, X., Cheng, X.T., Cheng, Y., Cheng, Z., Chen, Z., Cheong, H., Cheong, J.K., Chernyak, B.V., Cherry, S., Cheung, C.F.R., Cheung, C.H.A., Cheung, K.H., Chevet, E., Chi, R.J., Chiang, A.K.S., Chiaradonna, F., Chiarelli, R., Chiariello, M., Chica, N., Chiocca, S., Chiong, M., Chiou, S.H., Chiramel, A.I., Chiurchiù, V., Cho, D.H., Choe, S.K., Choi, A.M.K., Choi, M.E., Choudhury, K.R., Chow, N.S., Chu, C.T., Chua, J.P., Chua, J.J.E., Chung, H., Chung, K.P., Chung, S., Chung, S.H., Chung, Y.L., Cianfanelli, V., Ciechomska, I.A., Cifuentes, M., Cinque, L., Cirak, S., Cirone, M., Clague, M.J., Clarke, R., Clementi, E., Coccia, E.M., Codogno, P., Cohen, E., Cohen, M.M, Colasanti, T., Colasuonno, F., Colbert, R.A., Colell, A., Čolić, M., Coll, N.S., Collins, M.O., Colombo, M.I., Colón-Ramos, D.A., Combaret, L., Comincini, S., Cominetti, M.R., Consiglio, A., Conte, A., Conti, F., Contu, V.R., Cookson, M.R., Coombs, K.M., Coppens, I., Corasaniti, M.T., Corkery, D.P., Cordes, N., Cortese, K., Costa, M.D.C., Costantino, S., Costelli, P., Coto-Montes, A., Crack, P.J., Crespo, J.L., Criollo, A., Crippa, V., Cristofani, R., Csizmadia, T., Cuadrado, A., Cui, B., Cui, J., Cui, Y., Cui, Y., Culetto, E., Cumino, A.C., Cybulsky, A.V., Czaja, M.J., Czuczwar, S.J., D'Adamo, S., D'Amelio, M., D'Arcangelo, D., D'Lugos, A.C., D'Orazi, G., da Silva, J.A., Dafsari, H.S., Dagda, R.K., Dagdas, Y., Daglia, M., Dai, X., Dai, Y., Dai, Y., Dal Col, J., Dalhaimer, P., Dalla Valle, L., Dallenga, T., Dalmasso, G., Damme, M., Dando, I., Dantuma, N.P., Darling, A.L., Das, H., Dasarathy, S., Dasari, S.K., Dash, S., Daumke, O., Dauphinee, A.N., Davies, J.S., Dávila, V.A., Davis, R.J., Davis, T., Dayalan Naidu, S., De Amicis, F., De Bosscher, K., De Felice, F., De Franceschi, L., De Leonibus, C., de Mattos Barbosa, M.G., De Meyer, G.R.Y., De Milito, A., De Nunzio, C., De Palma, C., De Santi, M., De Virgilio, C., De Zio, D., Debnath, J., DeBosch, B.J., Decuypere, J.P., Deehan, M.A., Deflorian, G., DeGregori, J., Dehay, B., Del Rio, G., Delaney, J.R., Delbridge, L.M.D., Delorme-Axford, E., Delpino, M.V., Demarchi, F., Dembitz, V., Demers, N.D., Deng, H., Deng, Z., Dengjel, J., Dent, P., Denton, D., DePamphilis, M.L., Der, C.J., Deretic, V., Descoteaux, A., Devis, L., Devkota, S., Devuyst, O., Dewson, G., Dharmasivam, M., Dhiman, R., di Bernardo, D., Di Cristina, M., Di Domenico, F., Di Fazio, P., Di Fonzo, A., Di Guardo, G., Di Guglielmo, G.M., Di Leo, L., Di Malta, C., Di Nardo, A., Di Rienzo, M., Di Sano, F., Diallinas, G., Diao, J., Diaz-Araya, G., Díaz-Laviada, I., Dickinson, J.M., Diederich, M., Dieudé, M., Dikic, I., Ding, S., Ding, W.X., Dini, L., Dinić, J., Dinic, M., Dinkova-Kostova, A.T., Dionne, M.S., Distler, J.H.W., Diwan, A., Dixon, I.M.C., Djavaheri-Mergny, M., Dobrinski, I., Dobrovinskaya, O., Dobrowolski, R., Dobson, R.C.J., Đokić, J., Dokmeci Emre, S., Donadelli, M., Dong, B., Dong, X., Dong, Z., Dorn Ii, G.W., Dotsch, V., Dou, H., Dou, J., Dowaidar, M., Dridi, S., Drucker, L., Du, A., Du, C., Du, G., Du, H.N., Du, L.L., du Toit, A., Duan, S.B., Duan, X., Duarte, S.P., Dubrovska, A., Dunlop, E.A., Dupont, N., Durán, R.V., Dwarakanath, B.S., Dyshlovoy, S.A., Ebrahimi-Fakhari, D., Eckhart, L., Edelstein, C.L., Efferth, T., Eftekharpour, E., Eichinger, L., Eid, N., Eisenberg, T., Eissa, N.T., Eissa, S., Ejarque, M., El Andaloussi, A., El-Hage, N., El-Naggar, S., Eleuteri, A.M., El-Shafey, E.S., Elgendy, M., Eliopoulos, A.G., Elizalde, M.M., Elks, P.M., Elsasser, H.P., Elsherbiny, E.S., Emerling, B.M., Emre, N.C.T., Eng, C.H., Engedal, N., Engelbrecht, A.M., Engelsen, A.S.T., Enserink, J.M., Escalante, R., Esclatine, A., Escobar-Henriques, M., Eskelinen, E.L., Espert, L., Eusebio, M.O., Fabrias, G., Fabrizi, C., Facchiano, A., Facchiano, F., Fadeel, B., Fader, C., Faesen, A.C., Fairlie, W.D., Falcó, A., Falkenburger, B.H., Fan, D., Fan, J., Fan, Y., Fang, E.F., Fang, Y., Fang, Y., Fanto, M., Farfel-Becker, T., Faure, M., Fazeli, G., Fedele, A.O., Feldman, A.M., Feng, D., Feng, J., Feng, L., Feng, Y., Feng, Y., Feng, W., Fenz Araujo, T., Ferguson, T.A., Fernández, A.F., Fernandez-Checa, J.C., Fernández-Veledo, S., Fernie, A.R., Ferrante, A.W., Ferraresi, A., Ferrari, M.F., Ferreira, J.C.B., Ferro-Novick, S., Figueras, A., Filadi, R., Filigheddu, N., Filippi-Chiela, E., Filomeni, G., Fimia, G.M., Fineschi, V., Finetti, F., Finkbeiner, S., Fisher, E.A., Fisher, P.B., Flamigni, F., Fliesler, S.J., Flo, T.H., Florance, I., Florey, O., Florio, T., Fodor, E., Follo, C., Fon, E.A., Forlino, A., Fornai, F., Fortini, P., Fracassi, A., Fraldi, A., Franco, B., Franco, R., Franconi, F., Frankel, L.B., Friedman, S.L., Fröhlich, L.F., Frühbeck, G., Fuentes, J.M., Fujiki, Y., Fujita, N., Fujiwara, Y., Fukuda, M., Fulda, S., Furic, L., Furuya, N., Fusco, C., Gack, M.U., Gaffke, L., Galadari, S., Galasso, A., Galindo, M.F., Gallolu Kankanamalage, S., Galluzzi, L., Galy, V., Gammoh, N., Gan, B., Ganley, I.G., Gao, F., Gao, H., Gao, M., Gao, P., Gao, S.J., Gao, W., Gao, X., Garcera, A., Garcia, M.N., Garcia, V.E., García-Del Portillo, F., Garcia-Escudero, V., Garcia-Garcia, A., Garcia-Macia, M., García-Moreno, D., Garcia-Ruiz, C., García-Sanz, P., Garg, A.D., Gargini, R., Garofalo, T., Garry, R.F., Gassen, N.C., Gatica, D., Ge, L., Ge, W., Geiss-Friedlander, R., Gelfi, C., Genschik, P., Gentle, I.E., Gerbino, V., Gerhardt, C., Germain, K., Germain, M., Gewirtz, D.A., Ghasemipour Afshar, E., Ghavami, S., Ghigo, A., Ghosh, M., Giamas, G., Giampietri, C., Giatromanolaki, A., Gibson, G.E., Gibson, S.B., Ginet, V., Giniger, E., Giorgi, C., Girao, H., Girardin, S.E., Giridharan, M., Giuliano, S., Giulivi, C., Giuriato, S., Giustiniani, J., Gluschko, A., Goder, V., Goginashvili, A., Golab, J., Goldstone, D.C., Golebiewska, A., Gomes, L.R., Gomez, R., Gómez-Sánchez, R., Gomez-Puerto, M.C., Gomez-Sintes, R., Gong, Q., Goni, F.M., González-Gallego, J., Gonzalez-Hernandez, T., Gonzalez-Polo, R.A., Gonzalez-Reyes, J.A., González-Rodríguez, P., Goping, I.S., Gorbatyuk, M.S., Gorbunov, N.V., Görgülü, K., Gorojod, R.M., Gorski, S.M., Goruppi, S., Gotor, C., Gottlieb, R.A., Gozes, I., Gozuacik, D., Graef, M., Gräler, M.H., Granatiero, V., Grasso, D., Gray, J.P., Green, D.R., Greenhough, A., Gregory, S.L., Griffin, E.F., Grinstaff, M.W., Gros, F., Grose, C., Gross, A.S., Gruber, F., Grumati, P., Grune, T., Gu, X., Guan, J.L., Guardia, C.M., Guda, K., Guerra, F., Guerri, C., Guha, P., Guillén, C., Gujar, S., Gukovskaya, A., Gukovsky, I., Gunst, J., Günther, A., Guntur, A.R., Guo, C., Guo, C., Guo, H., Guo, L.W., Guo, M., Gupta, P., Gupta, S.K., Gupta, S., Gupta, V.B., Gupta, V., Gustafsson, A.B., Gutterman, D.D., H B, R., Haapasalo, A., Haber, J.E., Hać, A., Hadano, S., Hafrén, A.J., Haidar, M., Hall, B.S., Halldén, G., Hamacher-Brady, A., Hamann, A., Hamasaki, M., Han, W., Hansen, M., Hanson, P.I., Hao, Z., Harada, M., Harhaji-Trajkovic, L., Hariharan, N., Haroon, N., Harris, J., Hasegawa, T., Hasima Nagoor, N., Haspel, J.A., Haucke, V., Hawkins, W.D., Hay, B.A., Haynes, C.M., Hayrabedyan, S.B., Hays, T.S., He, C., He, Q., He, R.R., He, Y.W., He, Y.Y., Heakal, Y., Heberle, A.M., Hejtmancik, J.F., Helgason, G.V., Henkel, V., Herb, M., Hergovich, A., Herman-Antosiewicz, A., Hernández, A., Hernandez, C., Hernandez-Diaz, S., Hernandez-Gea, V., Herpin, A., Herreros, J., Hervás, J.H., Hesselson, D., Hetz, C., Heussler, V.T., Higuchi, Y., Hilfiker, S., Hill, J.A., Hlavacek, W.S., Ho, E.A., Ho, I.H.T., Ho, P.W.L., Ho, S.L., Ho, W.Y., Hobbs, G.A., Hochstrasser, M., Hoet, P.H.M., Hofius, D., Hofman, P., Höhn, A., Holmberg, C.I., Hombrebueno, J.R., Yi-Ren Hong, C.W.H., Hooper, L.V., Hoppe, T., Horos, R., Hoshida, Y., Hsin, I.L., Hsu, H.Y., Hu, B., Hu, D., Hu, L.F., Hu, M.C., Hu, R., Hu, W., Hu, Y.C., Hu, Z.W., Hua, F., Hua, J., Hua, Y., Huan, C., Huang, C., Huang, C., Huang, C., Huang, C., Huang, H., Huang, K., Huang, M.L.H., Huang, R., Huang, S., Huang, T., Huang, X., Huang, Y.J., Huber, T.B., Hubert, V., Hubner, C.A., Hughes, S.M., Hughes, W.E., Humbert, M., Hummer, G., Hurley, J.H., Hussain, S., Hussain, S., Hussey, P.J., Hutabarat, M., Hwang, H.Y., Hwang, S., Ieni, A., Ikeda, F., Imagawa, Y., Imai, Y., Imbriano, C., Imoto, M., Inman, D.M., Inoki, K., Iovanna, J., Iozzo, R.V., Ippolito, G., Irazoqui, J.E., Iribarren, P., Ishaq, M., Ishikawa, M., Ishimwe, N., Isidoro, C., Ismail, N., Issazadeh-Navikas, S., Itakura, E., Ito, D., Ivankovic, D., Ivanova, S., Iyer, A.K.V., Izquierdo, J.M., Izumi, M., Jäättelä, M., Jabir, M.S., Jackson, W.T., Jacobo-Herrera, N., Jacomin, A.C., Jacquin, E., Jadiya, P., Jaeschke, H., Jagannath, C., Jakobi, A.J., Jakobsson, J., Janji, B., Jansen-Dürr, P., Jansson, P.J., Jantsch, J., Januszewski, S., Jassey, A., Jean, S., Jeltsch-David, H., Jendelova, P., Jenny, A., Jensen, T.E., Jessen, N., Jewell, J.L., Ji, J., Jia, L., Jia, R., Jiang, L., Jiang, Q., Jiang, R., Jiang, T., Jiang, X., Jiang, Y., Jimenez-Sanchez, M., Jin, E.J., Jin, F., Jin, H., Jin, L., Jin, L., Jin, M., Jin, S., Jo, E.K., Joffre, C., Johansen, T., Johnson, G.V.W., Johnston, S.A., Jokitalo, E., Jolly, M.K., Joosten, L.A.B., Jordan, J., Joseph, B., Ju, D., Ju, J.S., Ju, J., Juárez, E., Judith, D., Juhász, G., Jun, Y., Jung, C.H., Jung, S.C., Jung, Y.K., Jungbluth, H., Jungverdorben, J., Just, S., Kaarniranta, K., Kaasik, A., Kabuta, T., Kaganovich, D., Kahana, A., Kain, R., Kajimura, S., Kalamvoki, M., Kalia, M., Kalinowski, D.S., Kaludercic, N., Kalvari, I., Kaminska, J., Kaminskyy, V.O., Kanamori, H., Kanasaki, K., Kang, C., Kang, R., Kang, S.S., Kaniyappan, S., Kanki, T., Kanneganti, T.D., Kanthasamy, A.G., Kanthasamy, A., Kantorow, M., Kapuy, O., Karamouzis, M.V., Karim, M.D.R., Karmakar, P., Katare, R.G., Kato, M., Kaufmann, S.H.E., Kauppinen, A., Kaushal, G.P., Kaushik, S., Kawasaki, K., Kazan, K., Ke, P.Y., Keating, D.J., Keber, U., Kehrl, J.H., Keller, K.E., Keller, C.W., Kemper, J.K., Kenific, C.M., Kepp, O., Kermorgant, S., Kern, A., Ketteler, R., Keulers, T.G., Khalfin, B., Khalil, H., Khambu, B., Khan, S.Y., Khandelwal, V.K.M., Khandia, R., Kho, W., Khobrekar, N.V., Khuansuwan, S., Khundadze, M., Killackey, S.A., Kim, D., Kim, D.R., Kim, D.H., Kim, D.E., Kim, E.Y., Kim, E.K., Kim, H.R., Kim, H.S., Kim, H.R., Kim, J.H., Kim, J.K., Kim, J.H., Kim, J., Kim, J.H., Kim, K.I.I., Kim, P.K., Kim, S.J., Kimball, S.R., Kimchi, A., Kimmelman, A.C., Kimura, T., King, M.A., Kinghorn, K.J., Kinsey, C.G., Kirkin, V., Kirshenbaum, L.A., Kiselev, S.L., Kishi, S., Kitamoto, K., Kitaoka, Y., Kitazato, K., Kitsis, R.N., Kittler, J.T., Kjaerulff, O., Klein, P.S., Klopstock, T., Klucken, J., Knævelsrud, H., Knorr, R.L., Ko, B.C.B., Ko, F., Ko, J.L., Kobayashi, H., Kobayashi, S., Koch, I., Koch, J.C., Koenig, U., Kögel, D., Koh, Y.H., Koike, M., Kohlwein, S.D., Kocaturk, N.M., Komatsu, M., König, J., Kono, T., Kopp, B.T., Korcsmaros, T., Korkmaz, G., Korolchuk, V.I., Korsnes, M.S., Koskela, A., Kota, J., Kotake, Y., Kotler, M.L., Kou, Y., Koukourakis, M.I., Koustas, E., Kovacs, A.L., Kovács, T., Koya, D., Kozako, T., Kraft, C., Krainc, D., Krämer, H., Krasnodembskaya, A.D., Kretz-Remy, C., Kroemer, G., Ktistakis, N.T., Kuchitsu, K., Kuenen, S., Kuerschner, L., Kukar, T., Kumar, A., Kumar, A., Kumar, D., Kumar, D., Kumar, S., Kume, S., Kumsta, C., Kundu, C.N., Kundu, M., Kunnumakkara, A.B., Kurgan, L., Kutateladze, T.G., Kutlu, O., Kwak, S.A., Kwon, H.J., Kwon, T.K., Kwon, Y.T., Kyrmizi, I., La Spada, A., Labonté, P., Ladoire, S., Laface, I., Lafont, F., Lagace, D.C., Lahiri, V., Lai, Z., Laird, A.S., Lakkaraju, A., Lamark, T., Lan, S.H., Landajuela, A., Lane, D.J.R., Lane, J.D., Lang, C.H., Lange, C., Langel, Ü., Langer, R., Lapaquette, P., Laporte, J., LaRusso, N.F., Lastres-Becker, I., Lau, W.C.Y., Laurie, G.W., Lavandero, S., Law, B.Y.K., Law, H.K.W., Layfield, R., Le, W., Le Stunff, H., Leary, A.Y., Lebrun, J.J., Leck, L.Y.W., Leduc-Gaudet, J.P., Lee, C., Lee, C.P., Lee, D.H., Lee, E.B., Lee, E.F., Lee, G.M., Lee, H.J., Lee, H.K., Lee, J.M., Lee, J.S., Lee, J.A., Lee, J.Y., Lee, J.H., Lee, M., Lee, M.G., Lee, M.J., Lee, M.S., Lee, S.Y., Lee, S.J., Lee, S.Y., Lee, S.B., Lee, W.H., Lee, Y.R., Lee, Y.H., Lee, Y., Lefebvre, C., Legouis, R., Lei, Y.L., Lei, Y., Leikin, S., Leitinger, G., Lemus, L., Leng, S., Lenoir, O., Lenz, G., Lenz, H.J., Lenzi, P., León, Y., Leopoldino, A.M., Leschczyk, C., Leskelä, S., Letellier, E., Leung, C.T., Leung, P.S., Leventhal, J.S., Levine, B., Lewis, P.A., Ley, K., Li, B., Li, D.Q., Li, J., Li, J., Li, J., Li, K., Li, L., Li, M., Li, M., Li, M., Li, M., Li, M., Li, P.L., Li, M.Q., Li, Q., Li, S., Li, T., Li, W., Li, W., Li, X., Li, Y.P., Li, Y., Li, Z., Li, Z., Li, Z., Lian, J., Liang, C., Liang, Q., Liang, W., Liang, Y., Liang, Y.T., Liao, G., Liao, L., Liao, M., Liao, Y.F., Librizzi, M., Lie, P.P.Y., Lilly, M.A., Lim, H.J., Lima, T.R.R., Limana, F., Lin, C., Lin, C.W., Lin, D.S., Lin, F.C., Lin, J.D., Lin, K.M., Lin, K.H., Lin, L.T., Lin, P.H., Lin, Q., Lin, S., Lin, S.J., Lin, W., Lin, X., Lin, Y.X., Lin, Y.S., Linden, R., Lindner, P., Ling, S.C., Lingor, P., Linnemann, A.K., Liou, Y.C., Lipinski, M.M., Lipovšek, S., Lira, V.A., Lisiak, N., Liton, P.B., Liu, C., Liu, C.H., Liu, C.F., Liu, C.H., Liu, F., Liu, H., Liu, H.S., Liu, H.F., Liu, H., Liu, J., Liu, J., Liu, J., Liu, L., Liu, L., Liu, M., Liu, Q., Liu, W., Liu, W., Liu, X.H., Liu, X., Liu, X., Liu, X., Liu, X., Liu, Y., Liu, Y., Liu, Y., Liu, Y., Liu, Y., Livingston, J.A., Lizard, G., Lizcano, J.M., Ljubojevic-Holzer, S., LLeonart, M.E., Llobet-Navàs, D., Llorente, A., Lo, C.H., Lobato-Márquez, D., Long, Q., Long, Y.C., Loos, B., Loos, J.A., López, M.G., López-Doménech, G., López-Guerrero, J.A., López-Jiménez, A.T., López-Pérez, O., López-Valero, I., Lorenowicz, M.J., Lorente, M., Lorincz, P., Lossi, L., Lotersztajn, S., Lovat, P.E., Lovell, J.F., Lovy, A., Lőw, P., Lu, G., Lu, H., Lu, J.H., Lu, J.J., Lu, M., Lu, S., Luciani, A., Lucocq, J.M., Ludovico, P., Luftig, M.A., Luhr, M., Luis-Ravelo, D., Lum, J.J., Luna-Dulcey, L., Lund, A.H., Lund, V.K., Lünemann, J.D., Lüningschrör, P., Luo, H., Luo, R., Luo, S., Luo, Z., Luparello, C., Lüscher, B., Luu, L., Lyakhovich, A., Lyamzaev, K.G., Lystad, A.H., Lytvynchuk, L., Ma, A.C., Ma, C., Ma, M., Ma, N.F., Ma, Q.H., Ma, X., Ma, Y., Ma, Z., MacDougald, O.A., Macian, F., MacIntosh, G.C., MacKeigan, J.P., Macleod, K.F., Maday, S., Madeo, F., Madesh, M., Madl, T., Madrigal-Matute, J., Maeda, A., Maejima, Y., Magarinos, M., Mahavadi, P., Maiani, E., Maiese, K., Maiti, P., Maiuri, M.C., Majello, B., Major, M.B., Makareeva, E., Malik, F., Mallilankaraman, K., Malorni, W., Maloyan, A., Mammadova, N., Man, G.C.W., Manai, F., Mancias, J.D., Mandelkow, E.M., Mandell, M.A., Manfredi, A.A., Manjili, M.H., Manjithaya, R., Manque, P., Manshian, B.B., Manzano, R., Manzoni, C., Mao, K., Marchese, C., Marchetti, S., Marconi, A.M., Marcucci, F., Mardente, S., Mareninova, O.A., Margeta, M., Mari, M., Marinelli, S., Marinelli, O., Mariño, G., Mariotto, S., Marshall, R.S., Marten, M.R., Martens, S., Martin, A.P.J., Martin, K.R., Martin, S., Martin, S., Martín-Segura, A., Martín-Acebes, M.A., Martin-Burriel, I., Martin-Rincon, M., Martin-Sanz, P., Martina, J.A., Martinet, W., Martinez, A., Martinez, A., Martinez, J., Martinez Velazquez, M., Martinez-Lopez, N., Martinez-Vicente, M., Martins, D.O., Martins, J.O., Martins, W.K., Martins-Marques, T., Marzetti, E., Masaldan, S., Masclaux-Daubresse, C., Mashek, D.G., Massa, V., Massieu, L., Masson, G.R., Masuelli, L., Masyuk, A.I., Masyuk, T.V., Matarrese, P., Matheu, A., Matoba, S., Matsuzaki, S., Mattar, P., Matte, A., Mattoscio, D., Mauriz, J.L., Mauthe, M., Mauvezin, C., Maverakis, E., Maycotte, P., Mayer, J., Mazzoccoli, G., Mazzoni, C., Mazzulli, J.R., McCarty, N., McDonald, C., McGill, M.R., McKenna, S.L., McLaughlin, B.A., McLoughlin, F., McNiven, M.A., McWilliams, T.G., Mechta-Grigoriou, F., Medeiros, T.C., Medina, D.L., Megeney, L.Y., Megyeri, K., Mehrpour, M., Mehta, J.L., Meijer, A.J., Meijer, A.H., Mejlvang, J., Meléndez, A., Melk, A., Memisoglu, G., Mendes, A.F., Meng, D., Meng, F., Meng, T., Menna-Barreto, R., Menon, M.B., Mercer, C., Mercier, A.E., Mergny, J.L., Merighi, A., Merkley, S.D., Merla, G., Meske, V., Mestre, A.C., Metur, S.P., Meyer, C., Meyer, H., Mi, W., Mialet-Perez, J., Miao, J., Micale, L., Miki, Y., Milan, E., Milczarek, M., Miller, D.L., Miller, S.I., Miller, S., Millward, S.W., Milosevic, I., Minina, E.A., Mirzaei, H., Mirzaei, H.R., Mirzaei, M., Mishra, A., Mishra, N., Mishra, P.K., Misirkic Marjanovic, M., Misasi, R., Misra, A., Misso, G., Mitchell, C., Mitou, G., Miura, T., Miyamoto, S., Miyazaki, M., Miyazaki, M., Miyazaki, T., Miyazawa, K., Mizushima, N., Mogensen, T.H., Mograbi, B., Mohammadinejad, R., Mohamud, Y., Mohanty, A., Mohapatra, S., Möhlmann, T., Mohmmed, A., Moles, A., Moley, K.H., Molinari, M., Mollace, V., Møller, A.B., Mollereau, B., Mollinedo, F., Montagna, C., Monteiro, M.J., Montella, A., Montes, L.R., Montico, B., Mony, V.K., Monzio Compagnoni, G., Moore, M.N., Moosavi, M.A., Mora, A.L., Mora, M., Morales-Alamo, D., Moratalla, R., Moreira, P.I., Morelli, E., Moreno, S., Moreno-Blas, D., Moresi, V., Morga, B., Morgan, A.H., Morin, F., Morishita, H., Moritz, O.L., Moriyama, M., Moriyasu, Y., Morleo, M., Morselli, E., Moruno-Manchon, J.F., Moscat, J., Mostowy, S., Motori, E., Moura, A.F., Moustaid-Moussa, N., Mrakovcic, M., Muciño-Hernández, G., Mukherjee, A., Mukhopadhyay, S., Mulcahy Levy, J.M., Mulero, V., Muller, S., Münch, C., Munjal, A., Munoz-Canoves, P., Muñoz-Galdeano, T., Münz, C., Murakawa, T., Muratori, C., Murphy, B.M., Murphy, J.P., Murthy, A., Myöhänen, T.T., Mysorekar, I.U., Mytych, J., Nabavi, S.M., Nabissi, M., Nagy, P., Nah, J., Nahimana, A., Nakagawa, I., Nakamura, K., Nakatogawa, H., Nandi, S.S., Nanjundan, M., Nanni, M., Napolitano, G., Nardacci, R., Narita, M., Nassif, M., Nathan, I., Natsumeda, M., Naude, R.J., Naumann, C., Naveiras, O., Navid, F., Nawrocki, S.T., Nazarko, T.Y., Nazio, F., Negoita, F., Neill, T., Neisch, A.L., Neri, L.M., Netea, M.G., Neubert, P., Neufeld, T.P., Neumann, D., Neutzner, A., Newton, P.T., Ney, P.A., Nezis, I.P., Ng, C.C.W., Ng, T.B., Nguyen, H.T.T., Nguyen, L.T., Ni, H.M., Ní Cheallaigh, C., Ni, Z., Nicolao, M.C., Nicoli, F., Nieto-Diaz, M., Nilsson, P., Ning, S., Niranjan, R., Nishimune, H., Niso-Santano, M., Nixon, R.A., Nobili, A., Nobrega, C., Noda, T., Nogueira-Recalde, U., Nolan, T.M., Nombela, I., Novak, I., Novoa, B., Nozawa, T., Nukina, N., Nussbaum-Krammer, C., Nylandsted, J., O'Donovan, T.R., O'Leary, S.M., O'Rourke, E.J., O'Sullivan, M.P., O'Sullivan, T.E., Oddo, S., Oehme, I., Ogawa, M., Ogier-Denis, E., Ogmundsdottir, M.H., Ogretmen, B., Oh, G.T., Oh, S.H., Oh, Y.J., Ohama, T., Ohashi, Y., Ohmuraya, M., Oikonomou, V., Ojha, R., Okamoto, K., Okazawa, H., Oku, M., Oliván, S., Oliveira, J.M.A., Ollmann, M., Olzmann, J.A., Omari, S., Omary, M.B., Önal, G., Ondrej, M., Ong, S.B., Ong, S.G., Onnis, A., Orellana, J.A., Orellana-Muñoz, S., Ortega-Villaizan, M.D.M., Ortiz-Gonzalez, X.R., Ortona, E., Osiewacz, H.D., Osman, A.H.K., Osta, R., Otegui, M.S., Otsu, K., Ott, C., Ottobrini, L., Ou, J.H.J., Outeiro, T.F., Oynebraten, I., Ozturk, M., Pagès, G., Pahari, S., Pajares, M., Pajvani, U.B., Pal, R., Paladino, S., Pallet, N., Palmieri, M., Palmisano, G., Palumbo, C., Pampaloni, F., Pan, L., Pan, Q., Pan, W:, Pan, X., Panasyuk, G., Pandey, R., Pandey, U.B., Pandya, V., Paneni, F., Pang, S.Y., Panzarini, E., Papademetrio, D.L., Papaleo, E., Papinski, D., Papp, D., Park, E.C., Park, H.T., Park, J.M., Park, J.I., Park, J.T., Park, J., Park, S.C., Park, S.Y., Parola, A.H., Parys, J.B., Pasquier, A., Pasquier, B., Passos, J.F., Pastore, N., Patel, H.H., Patschan, D., Pattingre, S., Pedraza-Alva, G., Pedraza-Chaverri, J., Pedrozo, Z., Pei, G., Pei, J., Peled-Zehavi, H., Pellegrini, J.M., Pelletier, J., Peñalva, M.A., Peng, D., Peng, Y., Penna, F., Pennuto, M., Pentimalli, F., Pereira, C.M.F., Pereira, G.J.S., Pereira, L.C., Pereira de Almeida, L., Perera, N.D., Pérez-Lara, A., Perez-Oliva, A.B., Pérez-Pérez, M.E., Periyasamy, P., Perl, A., Perrotta, C., Perrotta, I., Pestell, R.G., Petersen, M., Petrache, I., Petrovski, G., Pfirrmann, T., Pfister, A.S., Philips, J.A., Pi, H., Picca, A., Pickrell, A.M., Picot, S., Pierantoni, G.M., Pierdominici, M., Pierre, P., Pierrefite-Carle, V., Pierzynowska, K., Pietrocola, F., Pietruczuk, M., Pignata, C., Pimentel-Muiños, F.X., Pinar, M., Pinheiro, R.O., Pinkas-Kramarski, R., Pinton, P., Pircs, K., Piya, S., Pizzo, P., Plantinga, T.S., Platta, H.W., Plaza-Zabala, A., Plomann, M., Plotnikov, E.Y., Plun-Favreau, H., Pluta, R., Pocock, R., Pöggeler, S., Pohl, C., Poirot, M., Poletti, A., Ponpuak, M., Popelka, H., Popova, B., Porta, H., Porte Alcon, S., Portilla-Fernandez, E., Post, M., Potts, M.B., Poulton, J., Powers, T., Prahlad, V., Prajsnar, T.K., Praticò, D., Prencipe, R., Priault, M., Proikas-Cezanne, T., Promponas, V.J., Proud, C.G., Puertollano, R., Puglielli, L., Pulinilkunnil, T., Puri, D., Puri, R., Puyal, J., Qi, X., Qi, Y., Qian, W., Qiang, L., Qiu, Y., Quadrilatero, J., Quarleri, J., Raben, N., Rabinowich, H., Ragona, D., Ragusa, M.J., Rahimi, N., Rahmati, M., Raia, V., Raimundo, N., Rajasekaran, N.S., Ramachandra Rao, S., Rami, A., Ramírez-Pardo, I., Ramsden, D.B., Randow, F., Rangarajan, P.N., Ranieri, D., Rao, H., Rao, L., Rao, R., Rathore, S., Ratnayaka, J.A., Ratovitski, E.A., Ravanan, P., Ravegnini, G., Ray, S.K., Razani, B., Rebecca, V., Reggiori, F., Régnier-Vigouroux, A., Reichert, A.S., Reigada, D., Reiling, J.H., Rein, T., Reipert, S., Rekha, R.S., Ren, H., Ren, J., Ren, W., Renault, T., Renga, G., Reue, K., Rewitz, K., Ribeiro de Andrade Ramos, B., Riazuddin, S.A., Ribeiro-Rodrigues, T.M., Ricci, J.E., Ricci, R., Riccio, V., Richardson, D.R., Rikihisa, Y., Risbud, M.V., Risueño, R.M., Ritis, K., Rizza, S., Rizzuto, R., Roberts, H.C., Roberts, L.D., Robinson, K.J., Roccheri, M.C., Rocchi, S., Rodney, G.G., Rodrigues, T., Rodrigues Silva, V.R., Rodriguez, A., Rodriguez-Barrueco, R., Rodriguez-Henche, N., Rodriguez-Rocha, H., Roelofs, J., Rogers, R.S., Rogov, V.V., Rojo, A.I., Rolka, K., Romanello, V., Romani, L., Romano, A., Romano, P.S., Romeo-Guitart, D., Romero, L.C., Romero, M., Roney, J.C., Rongo, C., Roperto, S., Rosenfeldt, M.T., Rosenstiel, P., Rosenwald, A.G., Roth, K.A., Roth, L., Roth, S., Rouschop, K.M.A., Roussel, B.D., Roux, S., Rovere-Querini, P., Roy, A., Rozieres, A., Ruano, D., Rubinsztein, D.C., Rubtsova, M.P., Ruckdeschel, K., Ruckenstuhl, C., Rudolf, E., Rudolf, R., Ruggieri, A., Ruparelia, A.A., Rusmini, P., Russell, R.R., Russo, G.L., Russo, M., Russo, R., Ryabaya, O.O., Ryan, K.M., Ryu, K.Y., Sabater-Arcis, M., Sachdev, U., Sacher, M., Sachse, C., Sadhu, A., Sadoshima, J., Safren, N., Saftig, P., Sagona, A.P., Sahay, G., Sahebkar, A., Sahin, M., Sahin, O., Sahni, S., Saito, N., Saito, S., Saito, T., Sakai, R., Sakai, Y., Sakamaki, J.I., Saksela, K., Salazar, G., Salazar-Degracia, A., Salekdeh, G.H., Saluja, A.K., Sampaio-Marques, B., Sanchez, M.C., Sanchez-Alcazar, J.A., Sanchez-Vera, V., Sancho-Shimizu, V., Sanderson, J.T., Sandri, M., Santaguida, S., Santambrogio, L., Santana, M.M., Santoni, G., Sanz, A., Sanz, P., Saran, S., Sardiello, M., Sargeant, T.J., Sarin, A., Sarkar, C., Sarkar, S., Sarrias, M.R., Sarkar, S., Sarmah, D.T., Sarparanta, J., Sathyanarayan, A., Sathyanarayanan, R., Scaglione, K.M., Scatozza, F., Schaefer, L., Schafer, Z.T., Schaible, U.E., Schapira, A.H.V., Scharl, M., Schatzl, H.M., Schein, C.H., Scheper, W., Scheuring, D., Schiaffino, M.V., Schiappacassi, M., Schindl, R., Schlattner, U., Schmidt, O., Schmitt, R., Schmidt, S.D., Schmitz, I., Schmukler, E., Schneider, A., Schneider, B.E., Schober, R., Schoijet, A.C., Schott, M.B., Schramm, M., Schröder, B., Schuh, K., Schüller, C., Schulze, R.L., Schürmanns, L., Schwamborn, J.C., Schwarten, M., Scialo, F., Sciarretta, S., Scott, M.J., Scotto, K.W., Scovassi, A.I., Scrima, A., Scrivo, A., Sebastian, D., Sebti, S., Sedej, S., Segatori, L., Segev, N., Seglen, P.O., Seiliez, I., Seki, E., Selleck, S.B., Sellke, F.W., Selsby, J.T., Sendtner, M., Senturk, S., Seranova, E., Sergi, C., Serra-Moreno, R., Sesaki, H., Settembre, C., Setty, S.R.G., Sgarbi, G., Sha, O., Shacka, J.J., Shah, J.A., Shang, D., Shao, C., Shao, F., Sharbati, S., Sharkey, L.M., Sharma, D., Sharma, G., Sharma, K., Sharma, P., Sharma, S., Shen, H.M., Shen, H., Shen, J., Shen, M., Shen, W., Shen, Z., Sheng, R., Sheng, Z., Sheng, Z.H., Shi, J., Shi, X., Shi, Y.H., Shiba-Fukushima, K., Shieh, J.J., Shimada, Y., Shimizu, S., Shimozawa, M., Shintani, T., Shoemaker, C.J., Shojaei, S., Shoji, I., Shravage, B.V., Shridhar, V., Shu, C.W., Shu, H.B., Shui, K., Shukla, A.K., Shutt, T.E., Sica, V., Siddiqui, A., Sierra, A., Sierra-Torre, V., Signorelli, S., Sil, P., Silva, B.J.A., Silva, J.D., Silva-Pavez, E., Silvente-Poirot, S., Simmonds, R.E., Simon, A.K., Simon, H.U., Simons, M., Singh, A., Singh, L.P., Singh, R., Singh, S.V., Singh, S.K., Singh, S.B., Singh, S., Singh, S.P., Sinha, D., Sinha, R.A., Sinha, S., Sirko, A., Sirohi, K., Sivridis, E.L., Skendros, P., Skirycz, A., Slaninová, I., Smaili, S.S., Smertenko, A., Smith, M.D., Soenen, S.J., Sohn, E.J., Sok, S.P.M., Solaini, G., Soldati, T., Soleimanpour, S.A., Soler, R.M., Solovchenko, A., Somarelli, J.A., Sonawane, A., Song, F., Song, H.K., Song, J.X., Song, K., Song, Z., Soria, L.R., Sorice, M., Soukas, A.A., Soukup, S.F., Sousa, D., Sousa, N., Spagnuolo, P.A., Spector, S.A., Srinivas Bharath, M.M., St Clair, D., Stagni, V., Staiano, L., Stalnecker, C.A., Stankov, M.V., Stathopulos, P.B., Stefan, K., Stefan, S.M., Stefanis, L., Steffan, J.S., Steinkasserer, A., Stenmark, H., Sterneckert, J., Stevens, C., Stoka, V., Storch, S., Stork, B., Strappazzon, F., Strohecker, A.M., Stupack, D.G., Su, H., Su, L.Yy, Su, L., Suarez-Fontes, A.M., Subauste, C.S., Subbian, S., Subirada, P.V., Sudhandiran, G., Sue, C.M., Sui, X., Summers, C., Sun, G., Sun, J., Sun, K., Sun, M.X., Sun, Q., Sun, Y., Sun, Z., Sunahara, K.K.S., Sundberg, E., Susztak, K., Sutovsky, P., Suzuki, H., Sweeney, G., Symons, J.D., Sze, S.C.W., Szewczyk, N.J., Tabęcka-Łonczynska, A., Tabolacci, C., Tacke, F., Taegtmeyer, H., Tafani, M., Tagaya, M., Tai, H., Tait, S.W.G., Takahashi, Y., Takats, S., Talwar, P., Tam, C., Tam, S.Y., Tampellini, D., Tamura, A., Tan, C.T., Tan, E.K., Tan, Y.Q., Tanaka, M., Tanaka, M., Tang, D., Tang, J., Tang, T.S., Tanida, I., Tao, Z., Taouis, M., Tatenhorst, L., Tavernarakis, N., Taylor, A., Taylor, G.A., Taylor, J.M., Tchetina, E., Tee, A.R., Tegeder, I., Teis, D., Teixeira, N., Teixeira-Clerc, F., Tekirdag, K.A., Tencomnao, T., Tenreiro, S., Tepikin, A.V., Testillano, P.S., Tettamanti, G., Tharaux, P.L., Thedieck, K., Thekkinghat, A.A., Thellung, S., Thinwa, J.W., Thirumalaikumar, V.P., Thomas, S.M., Thomes, P.G., Thorburn, A., Thukral, L., Thum, T., Thumm, M., Tian, L., Tichy, A., Till, A., Timmerman, V., Titorenko, V.I., Todi, S.V., Todorova, K., Toivonen, J.M., Tomaipitinca, L., Tomar, D., Tomas-Zapico, C., Tomić, S., Tong, B.C.K., Tong, C., Tong, X., Tooze, S.A., Torgersen, M.L., Torii, S., Torres-López, L., Torriglia, A., Towers, C.G., Towns, R., Toyokuni, S., Trajkovic, V., Tramontano, D., Tran, Q.G., Travassos, L.H., Trelford, C.B., Tremel, S., Trougakos, I.P., Tsao, B.P., Tschan, M.P., Tse, H.F., Tse, T.F., Tsugawa, H., Tsvetkov, A.S., Tumbarello, D.A., Tumtas, Y., Tuñón, M.J., Turcotte, S., Turk, B., Turk, V., Turner, B.J., Tuxworth, R.I., Tyler, J.K., Tyutereva, E.V., Uchiyama, Y., Ugun-Klusek, A., Uhlig, H.H., Ułamek-Kozioł, M., Ulasov, I.V., Umekawa, M., Ungermann, C., Unno, R., Urbe, S., Uribe-Carretero, E., Üstün, S., Uversky, V.N., Vaccari, T., Vaccaro, M.I., Vahsen, B.F., Vakifahmetoglu-Norberg, H., Valdor, R., Valente, M.J., Valko, A., Vallee, R.B., Valverde, A.M., Van den Berghe, G., van der Veen, S., Van Kaer, L., van Loosdregt, J., van Wijk, S.J.L., Vandenberghe, W., Vanhorebeek, I., Vannier-Santos, M.A., Vannini, N., Vanrell, M.C., Vantaggiato, C., Varano, G., Varela-Nieto, I., Varga, M., Vasconcelos, M.H., Vats, S., Vavvas, D.G., Vega-Naredo, I., Vega-Rubin-de-Celis, S., Velasco, G., Velázquez, A.P., Vellai, T., Vellenga, E., Velotti, F., Verdier, M., Verginis, P., Vergne, I., Verkade, P., Verma, M., Verstreken, P., Vervliet, T., Vervoorts, J., Vessoni, A.T., Victor, V.M., Vidal, M., Vidoni, C., Vieira, O.V., Vierstra, R.D., Viganó, S., Vihinen, H., Vijayan, V., Vila, M., Vilar, M., Villalba, J.M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M.T., Visnjic, D., Vitale, I., Vocadlo, D.J., Voitsekhovskaja, O.V., Volonté, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M.A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K.A., Wakatsuki, S., Walker, D.W., Walker, M.J., Walker, S.A., Walter, J., Wandosell, F.G., Wang, B., Wang, C.Y., Wang, C., Wang, C., Wang, C., Wang, C.Y., Wang, D., Wang, F., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H., Wang, H., Wang, H.G., Wang, J., Wang, J., Wang, J., Wang, J., Wang, K., Wang, L., Wang, L., Wang, M.H., Wang, M., Wang, N., Wang, P., Wang, P., Wang, P., Wang, P., Wang, Q.J., Wang, Q., Wang, Q.K., Wang, Q.A., Wang, W.T., Wang, W., Wang, X., Wang, X., Wang, Y., Wang, Y., Wang, Y., Wang, Y.Y., Wang, Y., Wang, Y., Wang, Y., Wang, Y., Wang, Z., Wang, Z., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzyńska, A., Weaver, T.E., Wegrzyn, G., Wehman, A.M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergräber, O.H., Weihl, C.C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R.H., Wen, X., Werner, A., Weykopf, B., Wheatley, S.P., Whitton, J.L., Whitworth, A.J., Wiktorska, K., Wildenberg, M.E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R.S.B., Williams, R.L., Williamson, P.R., Wilson, R.A., Winner, B., Winsor, N.J., Witkin, S.S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J.H., Wong, R.W., Wong, V.K.W., Wong, W.L., Wu, A.G., Wu, C., Wu, J., Wu, J., Wu, K.K., Wu, M., Wu, S.Y., Wu, S., Wu, S.Y., Wu, S., Wu, W.K.K., Wu, X., Wu, X., Wu, Y.W., Wu, Y., Xavier, R.J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H.T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C.M., Xie, M., Xie, Y., Xie, Z., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, J.R., Xu, L., Xu, W.W., Xu, X., Xue, Y., Yakhine-Diop, S.M.S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S.J., Yan, Z., Yanagi, Y., Yang, C., Yang, D.S., Yang, H., Yang, H.T., Yang, H., Yang, J.M., Yang, J., Yang, J., Yang, L., Yang, L., Yang, M., Yang, P.M., Yang, Q., Yang, S., Yang, S., Yang, S.F., Yang, W., Yang, W.Y., Yang, X., Yang, X., Yang, Y., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y.G., Yao, Y.M., Yasui, T., Yazdankhah, M., Yen, P.M., Yi, C., Yin, X.M., Yin, Y., Yin, Z., Yin, Z., Ying, M., Ying, Z., Yip, C.K., Yiu, S.P.T., Yoo, Y.H., Yoshida, K., Yoshii, S.R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, J., Yu, L., Yu, M.L., Yu, S.W., Yu, V.C., Yu, W.H., Yu, Z., Yu, Z., Yuan, J., Yuan, L.Q., Yuan, S., Yuan, S.S.F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R.L., Zacks, D.N., Zaffagnini, G., Zambelli, V.O., Zanella, I., Zang, Q.S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K.S., Zarebkohan, A., Zarrouk, A., Zeitlin, S.O., Zeng, J., Zeng, J.D., Žerovnik, E., Zhan, L., Zhang, B., Zhang, D.D., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H.L., Zhang, J., Zhang, J., Zhang, J.P., Zhang, K.Y.B., Zhang, L.W., Zhang, L., Zhang, L., Zhang, L., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X.W., Zhang, X., Zhang, X., Zhang, X., Zhang, X., Zhang, X.D., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y.D., Zhang, Y., Zhang, Y.Y., Zhang, Y., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X.F., Zhao, Y., Zhao, Y., Zhao, Y., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X.L., Zheng, Y., Zheng, Z.G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, H., Zhou, H., Zhou, J., Zhou, J., Zhou, J., Zhou, J., Zhou, K., Zhou, R., Zhou, X.J., Zhou, Y., Zhou, Y., Zhou, Y., Zhou, Z.Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G.Q., Zhu, H., Zhu, H., Zhu, H., Zhu, W.G., Zhu, Y., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C.M., Ziviani, E., Zoladek, T., Zong, W.X., Zorov, D.B., Zorzano, A., Zou, W., Zou, Z., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L. and Tong, C.K.
Autophagy 17
(1): 1-382.
8 February 2021
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S., Hopf, L.V.M., Bock-Bierbaum, T., Lally, C.C.M., Spahn, C.M.T. and Daumke, O.
Nature Communications 11
(1): 5506.
2 November 2020
Monogenic variants in dystonia: an exome-wide sequencing study.
Zech, M., Jech, R., Boesch, S., Škorvánek, M., Weber, S., Wagner, M., Zhao, C., Jochim, A., Necpál, J., Dincer, Y., Vill, K., Distelmaier, F., Stoklosa, M., Krenn, M., Grunwald, S., Bock-Bierbaum, T., Fečíková, A., Havránková, P., Roth, J., Příhodová, I., Adamovičová, M., Ulmanová, O., Bechyně, K., Danhofer, P., Veselý, B., Haň, V., Pavelekova, P., Gdovinová, Z., Mantel, T., Meindl, T., Sitzberger, A., Schröder, S., Blaschek, A., Roser, T., Bonfert, M.V., Haberlandt, E., Plecko, B., Leineweber, B., Berweck, S., Herberhold, T., Langguth, B., Švantnerová, J., Minár, M., Ramos-Rivera, G.A., Wojcik, M.H., Pajusalu, S., Õunap, K., Schatz, U.A., Pölsler, L., Milenkovic, I., Laccone, F., Pilshofer, V., Colombo, R., Patzer, S., Iuso, A., Vera, J., Troncoso, M., Fang, F., Prokisch, H., Wilbert, F., Eckenweiler, M., Graf, E., Westphal, D.S., Riedhammer, K.M., Brunet, T., Alhaddad, B., Berutti, R., Strom, T.M., Hecht, M., Baumann, M., Wolf, M., Telegrafi, A., Person, R.E., Zamora, F.M., Henderson, L.B., Weise, D., Musacchio, T., Volkmann, J., Szuto, A., Becker, J., Cremer, K., Sycha, T., Zimprich, F., Kraus, V., Makowski, C., Gonzalez-Alegre, P., Bardakjian, T.M., Ozelius, L.J., Vetro, A., Guerrini, R., Maier, E., Borggraefe, I., Kuster, A., Wortmann, S.B., Hackenberg, A., Steinfeld, R., Assmann, B., Staufner, C., Opladen, T., Růžička, E., Cohn, R.D., Dyment, D., Chung, W.K., Engels, H., Ceballos-Baumann, A., Ploski, R., Daumke, O., Haslinger, B., Mall, V., Oexle, K. and Winkelmann, J.
Lancet Neurology 19
(11): 908-918.
November 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Faelber, K., Dietrich, L., Noel, J.K., Wollweber, F., Pfitzner, A.K., Mühleip, A., Sánchez, R., Kudryashev, M., Chiaruttini, N., Lilie, H., Schlegel, J., Rosenbaum, E., Hessenberger, M., Matthaeus, C., Kunz, S., von der Malsburg, A., Noé, F., Roux, A., van der Laan, M., Kühlbrandt, W. and Daumke, O.
Nature 571
(7765): 429-433.
18 July 2019
FIP200 claw domain binding to p62 promotes autophagosome formation at ubiquitin condensates.
Turco, E., Witt, M., Abert, C., Bock-Bierbaum, T., Su, M.Y., Trapannone, R., Sztacho, M., Danieli, A., Shi, X., Zaffagnini, G., Gamper, A., Schuschnig, M., Fracchiolla, D., Bernklau, D., Romanov, J., Hartl, M., Hurley, J.H., Daumke, O. and Martens, S.
Molecular Cell 74
(2): 330-346.
18 April 2019
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J., Noel, J.K. and Low, H.H.
Nature Communications 9
(1): 3345.
21 August 2018
Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M., Zerbes, R.M., Rampelt, H., Kunz, S., Xavier, A.H., Purfürst, B., Lilie, H., Pfanner, N., van der Laan, M. and Daumke, O.
Nature Communications 8
: 15258.
31 May 2017
How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
Noel, J.K. and Whitford, P.C.
Nature Communications 7
: 13314.
31 October 2016
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
Crystal structure of the dynamin tetramer.
Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noé, F., Haucke, V., Daumke, O. and Eschenburg, S.
Nature 525
(7569): 404-408.
17 September 2015
New role for the (pro)renin receptor in T cell development.
Geisberger, S., Maschke, U., Gebhardt, M., Kleinewietfeld, M., Manzel, A., Linker, R.A., Chidgey, A., Dechend, R., Nguyen, G., Daumke, O., Muller, D.N., Wright, M.D. and Binger, K.J.
Blood 126
(4): 504-507.
23 July 2015
Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M. and Heinemann, U.
Nature Communications 5
: 5701.
11 December 2014
BAR domain scaffolds in dynamin-mediated membrane fission.
Daumke, O., Roux, A. and Haucke, V.
Cell 156
(5): 882-892.
27 February 2014
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C., Grabiger, S., Schwefel, D., Faelber, K., Rosenbaum, E., Mears, J., Rocks, O. and Daumke, O.
EMBO Journal 32
(9): 1280-1292.
2 May 2013
Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function.
Gao, S., von der Malsburg, A., Dick, A., Faelber, K., Schroeder, G.F., Haller, O., Kochs, G. and Daumke, O.
Immunity 35
(4): 514-525.
28 October 2011
Crystal structure of nucleotide-free dynamin.
Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noe, F. and Daumke, O.
Nature 477
(7366): 556-560.
29 September 2011
Structure of a classical MHC class I molecule that binds "non-classical" ligands.
Hee, C.S., Gao, S., Loll, B., Miller, M.M., Uchanska-Ziegler, B., Daumke, O. and Ziegler, A.
PLoS Biology 8
(12): e1000557.
7 December 2010
Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Gao, S., von der Malsburg, A., Paeschke, S., Behlke, J., Haller, O., Kochs, G. and Daumke, O.
Nature 465
(7297): 502-506.
27 May 2010
Host cell interactome of tyrosine-phosphorylated bacterial proteins.
Selbach, M., Paul, F.E., Brandt, S., Guye, P., Daumke, O., Backert, S., Dehio, C. and Mann, M.
Cell Host & Microbe 5
(4): 397-403.
23 April 2009
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
Daumke, O., Lundmark, R., Vallis, Y., Martens, S., Butler, P.J.G. and McMahon, H.T.
Nature 449
(7164): 923-927.
3 October 2007
De la Rosa, Kathrin
Diversification of antibodies: from V(D)J recombination to somatic exon shuffling.
Lebedin, M. and de la Rosa, K.
Annual Review of Cell and Developmental Biology 40
(1): 265-281.
October 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9
(92): eadi0042.
2 February 2024
Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M., Foglierini, M., Khorkova, S., Vázquez García, C., Ratswohl, C., Davydov, A.N., Turchaninova, M.A., Daubenberger, C., Chudakov, D.M., Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119
(36): e2205470119.
6 September 2022
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93
(9): 960-971.
September 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K. and Chu, V.T.
Science Advances 8
(22): eabm9106.
3 June 2022
Deubzer, Hedwig (ECRC)
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14
(1): 3936.
4 July 2023
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55
(5): 880-890.
May 2023
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M., Tucker, E., Dorel, M., Winkler, A., McGearey, A., Rodriguez-Fos, E., da Costa, B.M., Barker, K., Fyle, E., Calton, E., Eising, S., Ober, K., Hughes, D., Koutroumanidou, E., Carter, P., Stankunaite, R., Proszek, P., Jain, N., Rosswog, C., Dorado-Garcia, H., Molenaar, J.J., Hubank, M., Barone, G., Anderson, J., Lang, P., Deubzer, H.E., Künkele, A., Fischer, M., Eggert, A., Kloft, C., Henssen, A.G., Boettcher, M., Hertwig, F., Blüthgen, N., Chesler, L. and Schulte, J.H.
Molecular Cancer 21
(1): 126.
10 June 2022
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
Di Virgilio, Michela
RIF1 regulates early replication timing in murine B cells.
Malzl, D., Peycheva, M., Rahjouei, A., Gnan, S., Klein, K.N., Nazarova, M., Schoeberl, U.E., Gilbert, D.M., Buonomo, S.C.B., Di Virgilio, M., Neumann, T. and Pavri, R.
Nature Communications 14
(1): 8049.
11 December 2023
Turning science into cover art.
Dauben, H., Matic, I., Kidmose, R.T., Pedersen, B.P., Saha, T., Di Virgilio, M. and Sung, J.H.
Trends in Biochemical Sciences 48
(12): 1009-1011.
December 2023
DNA repair and antibody diversification: the 53BP1 paradigm.
Kabrani, E., Saha, T. and Di Virgilio, M.
Trends in Immunology 44
(10): 782-791.
October 2023
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13
(1): 4297.
25 July 2022
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
Charting a DNA repair roadmap for immunoglobulin class switch recombination.
Saha, T., Sundaravinayagam, D. and Di Virgilio, M.
Trends in Biochemical Sciences 46
(3): 184-199.
March 2021
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
Delgado-Benito, V., Rosen, D.B., Wang, Q., Gazumyan, A., Pai, J.A., Oliveira, T.Y., Sundaravinayagam, D., Zhang, W., Andreani, M., Keller, L., Kieffer-Kwon, K.R., Pękowska, A., Jung, S., Driesner, M., Subbotin, R.I., Casellas, R., Chait, B.T., Nussenzweig, M.C. and Di Virgilio, M.
Molecular Cell 72
(4): 636-649.
15 November 2018
SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K., Kranz, A., Fohgrub, J., Jolly, A., Bledau, A.S., Di Virgilio, M., Lesche, M., Dahl, A., Höfer, T., Stewart, A.F. and Waskow, C.
Blood 131
(12): 1311-1324.
22 March 2018
A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
Boege, Y., Malehmir, M., Healy, M.E., Bettermann, K., Lorentzen, A., Vucur, M., Ahuja, A.K., Böhm, F., Mertens, J.C., Shimizu, Y., Frick, L., Remouchamps, C., Mutreja, K., Kähne, T., Sundaravinayagam, D., Wolf, M.J., Rehrauer, H., Koppe, C., Speicher, T., Padrissa-Altés, S., Maire, R., Schattenberg, J.M., Jeong, J.S., Liu, Lei, Zwirner, S., Boger, R., Hüser, N., Davis, R.J., Müllhaupt, B., Moch, H., Schulze-Bergkamen, H., Clavien, P.A., Werner, S., Borsig, L., Luther, S.A., Jost, P.J., Weinlich, R., Unger, K., Behrens, A., Hillert, L., Dillon, C., Di Virgilio, M., Wallach, D., Dejardin, E., Zender, L., Naumann, M., Walczak, H., Green, D.R., Lopes, M., Lavrik, I., Luedde, T., Heikenwalder, M. and Weber, A.
Cancer Cell 32
(3): 342-359.
11 September 2017
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S., Chu, V.T., Yasuda, T., Franklin, A., Graf, R., Calado, D.P., Li, S., Imami, K., Selbach, M., Di Virgilio, M., Bullinger, L. and Rajewsky, K.
Immunity 43
(6): 1075-1086.
15 December 2015
Diebolder, Christoph
Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.
Wiechert, F., Unbehaun, A., Sprink, T., Seibel, H., Bürger, J., Loerke, J., Mielke, T., Diebolder, C.A., Schacherl, M. and Spahn, C.M.T.
Nucleic Acids Research
: gkae1191.
10 December 2024
(In Press)
Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Flügel, T., Schacherl, M., Unbehaun, A., Schroeer, B., Dabrowski, M., Bürger, J., Mielke, T., Sprink, T., Diebolder, C.A., Guillén Schlippe, Y.V. and Spahn, C.M.T.
Nature Communications 15
(1): 1756.
26 February 2024
Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14
(1): 6543.
17 October 2023
Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A., Sprink, T., Noel, J.K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C.M.T. and Daumke, O.
Nature Communications 13
(1): 7641.
10 December 2022
Diecke, Sebastian (MDC/BIH)
Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control.
Dobner, J., Diecke, S., Krutmann, J., Prigione, A. and Rossi, A.
Nature Communications 15
(1): 8547.
2 October 2024
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14
(1): 8043.
19 December 2023
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S., Lucht, M.T., Petzoldt, A., Kong, S., Sun, J., Vines, J.H., Telugu, N.S., Diecke, S., Kaas, T., Bullmann, T., Schmied, C., Löwe, D., King, J.S., Cho, W., Hallermann, S., Puchkov, D., Sigrist, S.J. and Haucke, V.
Science 382
(6667): 223-230.
12 October 2023
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J., Costanzo, M., Sanaki-Matsumiya, M., Girardot, C., Hayashi, M., Hayashi, K., Diecke, S., Hildebrandt, T.B., Lazzari, G., Wu, J., Petkov, S., Behr, R., Trivedi, V., Matsuda, M. and Ebisuya, M.
Cell Stem Cell 30
(7): 938-949.e7.
6 July 2023
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133
(13): e164637.
3 July 2023
Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M., Zywitza, V., Naitou, Y., Hamazaki, N., Goeritz, F., Hermes, R., Holtze, S., Lazzari, G., Galli, C., Stejskal, J., Diecke, S., Hildebrandt, T.B. and Hayashi, K.
Science Advances 8
(49): eabp9683.
9 December 2022
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I., Seeger, T., Bruyneel, A.A.N., Termglinchan, V., Monte, E., Lim, E.W., Vadgama, N., Furihata, T., Gavidia, A.A., Arthur Ataam, J., Bharucha, N., Martinez-Amador, N., Ameen, M., Nair, P., Serrano, R., Kaur, B., Feyen, D.A.M., Diecke, S., Snyder, M.P., Metallo, C.M., Mercola, M. and Karakikes, I.
European Heart Journal 43
(36): 3477-3489.
21 September 2022
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D., Ameen, M., Guo, H., Abilez, O.J., Tian, L., Mumbach, M.R., Diecke, S., Qin, X., Liu, Y., Yang, H., Ma, N., Gaddam, S., Cunningham, N.J., Gu, M., Neofytou, E., Prado, M., Hildebrandt, T.B., Karakikes, I., Chang, H.Y. and Wu, J.C.
Developmental Cell 54
(6): 694-709.
28 September 2020
Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El-Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., Lenz, C., Salinas, G., Diecke, S., Müller, C., Adham, I., Altmüller, J., Nürnberg, P., Paul, T., Zimmermann, W.H., Hasenfuss, G., Wollnik, B. and Cyganek, L.
Circulation 142
(11): 1059-1076.
15 September 2020
Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J., Marczenke, M., Rudolph, I.M., Nielsen, R., Storm, T., Ilsoe Christensen, E., Diecke, S., Emma, F. and Willnow, T.E.
Kidney International 98
(1): 159-167.
July 2020
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C.K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., Zhang, J.Z, Chen, X., Gil, I.P., Ameen, M., Sallam, K., Rhee, J.W., Churko, J.M., Chaudhary, R., Chour, T., Wang, P.J., Snyder, M.P., Chang, H.Y., Karakikes, I. and Wu, J.C.
Nature 572
(7769): 335-340.
15 August 2019
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K., Vogt, L., Greber, B., Diecke, S., Boccaccini, A.R., Scheibel, T. and Engel, F.B.
Advanced Functional Materials 28
(42): 1803951.
October 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M.B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. and Galli, C.
Nature Communications 9
(1): 2589.
4 July 2018
Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G., Kim, Y., de Almeida, P.E., Termglinchan, V., Diecke, S., Shao, N.Y., Wei, T.T., Yi, H., Dey, De., Nelakanti, R., Brouwer, T.P., Paik, D.T., Sagiv-Barfi, I., Han, A., Quax, P.H.A., Hamming, J.F., Levy, R., Davis, M.M. and Wu, J.C.
Cell Stem Cell 22
(4): 501-513.
5 April 2018
A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I., Termglinchan, V., Cepeda, D.A., Lee, J., Diecke, S., Hendel, A., Itzhaki, I., Ameen, M., Shrestha, R., Wu, H., Ma, N., Shao, N.Y., Seeger, T., Woo, N.A., Wilson, K.D., Matsa, E., Porteus, M.H., Sebastiano, V. and Wu, J.C.
Circulation Research 120
(10): 1561-1571.
12 May 2017
Dieterich, Christoph (BIMSB)
MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H., Schueler, M., Munschauer, M., Mastrobuoni, G., Chen, W., Kempa, S., Dieterich, C. and Landthaler, M.
Molecular Cell 54
(4): 573-585.
22 May 2014
Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M., Munschauer, M., Gregersen, L.H., Finzel, A., Loewer, A., Chen, W., Landthaler, M. and Dieterich, C.
Genome Biology 15
(1): R15.
13 January 2014
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G., Munschauer, M., Schwanhaeusser, B., Vasile, A., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., Wyler, E., Bonneau, R., Selbach, M., Dieterich, C. and Landthaler, M.
Molecular Cell 46
(5): 674-690.
8 June 2012
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C., Wang, Y., Gruen, D., Mastrobuoni, G., You, X., Tolle, D., Dodt, M., Mackowiak, S.D., Gogol-Doering, A., Oenal, P., Rybak, A., Ross, E., Alvarado, A.S., Kempa, S., Dieterich, C., Rajewsky, N. and Chen, W.
Genome Research 21
(7): 1193-1200.
July 2011
Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models.
Borchert, N., Dieterich, C., Krug, K., Schuetz, W., Jung, S., Nordheim, A., Sommer, R.J. and Macek, B.
Genome Research 20
(6): 837-486.
June 2010
Dietz, Rainer
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
An, J., Mehrhof, F., Harms, C., Lättig-Tünnemann, G., Lee, S.L.L., Endres, M., Li, M., Sellge, G., Mandic, A.D., Trautwein, C. and Donath, S.
Journal of Hepatology 58
(2): 297-305.
February 2013
TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure.
An, J., Harms, C., Lättig-Tünnemann, G., Sellge, G., Mandic, A.D., Malato, Y., Heuser, A., Endres, M., Trautwein, C. and Donath, S.
Hepatology 56
(2): 715-726.
August 2012
Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Milojkovic, A. and Simon, A.K.
Autophagy 8
(4): 445-544.
April 2012
Effect of binge drinking on the heart as assessed by cardiac magnetic resonance imaging.
Zagrosek, A., Messroghli, D., Schulz, O., Dietz, R. and Schulz-Menger, J.
JAMA: Journal of the American Medical Association 304
(12): 1328-1330.
22 September 2010
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patients.
Munoz Saravia, S.G., Haberland, A., Bartel, S., Araujo, R., Valda, G., Duchen, D., Diaz Ramirez, I., Borges, A.C., Wallukat, G. and Schimke, I.
Journal of the American College of Cardiology 56
(6): 526-527.
3 August 2010
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon their potential impact for early risk assessment in asymptomatic Chagas' patients.
Wallukat, G., Munoz Saravia, S.G., Haberland, A., Bartel, S., Araujo, R., Valda, G., Duchen, D., Diaz Ramirez, I., Borges, A.C. and Schimke, I.
Journal of the American College of Cardiology 55
(5): 463-468.
2 February 2010
Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling.
Rudolph, A., Abdel-Aty, H., Bohl, S., Boye, P., Zagrosek, A., Dietz, R. and Schulz-Menger, J.
Journal of the American College of Cardiology 53
(3): 284-291.
20 January 2009
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J., Fischer, J., Paskas, S., Heinig, M., Schulz, H., Goesele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., Gross, V., Hummel, O., Maatz, H., Patone, G., Saar, K., Vingron, M., Weldon, S.M., Lindpaintner, K., Hammock, B.D., Rohde, K., Dietz, R., Cook, S.A., Schunck, W.H., Luft, F.C. and Huebner, N.
Nature Genetics 40
(5): 529-537.
May 2008
The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance.
Friedrich, M.G., Abdel-Aty, H., Taylor, A.J., Schulz-Menger, J., Messroghli, D. and Dietz, R.
Journal of the American College of Cardiology 51
(16): 1581-1587.
22 April 2008
Subacute coronary stent thrombosis in cancer patients.
Gross, C.M., Posch, M.G., Geier, C., Olthoff, H., Kraemer, J., Dechend, R., Dietz, R. and Oezcelik, C.
Journal of the American College of Cardiology 51
(12): 1232-1233.
25 March 2008
Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Hauck, L., Harms, C., An, J., Rohne, J., Gertz, K., Endres, M., Dietz, R. and von Harsdorf, R.
Nature Medicine 14
(3): 315-324.
March 2008
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Donath, S., Li, P., Willenbockel, C., Al-Saadi, N., Gross, V., Willnow, T.E., Bader, M., Martin, U., Bauersachs, J., Wollert, K.C., Dietz, R. and von Harsdorf, R.
Circulation 113
(9): 1203-1212.
7 March 2006
Letter regarding article by Sharkey et al. "Acute and reversible cardiomyopathy provoked by stress in women from the United States".
Abdel-Aty, H., Dietz, R. and Schulz-Menger, J.
Circulation 112
: e51.
19 July 2005
Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
Kiyan, J., Kiyan, R., Haller, H. and Dumler, I.
EMBO Journal 24
(10): 1787-1797.
18 May 2005
Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Freund, C., Schmidt-Ullrich, R., Baurand, A., Dunger, S., Schneider, W., Loser, P., El-Jamali, A., Dietz, R., Scheidereit, C. and Bergmann, M.W.
Circulation 111
(18): 2319-2325.
1 January 2005
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction.
Abdel-Aty, H., Zagrosek, A., Schulz-Menger, J., Taylor, A.J., Messroghli, D., Kumar, A., Gross, M., Dietz, R. and Friedrich, M.G.
Circulation 109
(20): 2411-2416.
25 May 2004
Mortality and morbidity reduction with candesartan in patients with chronic heart failure and left ventricular systolic dysfunction. Results of the CHARM low-left ventricular ejection fraction trials.
Young, J.B., Dunlap, M.E., Pfeffer, M.A., Probstfield, J.L., Cohen-Solal, A., Dietz, R., Granger, C.B., Hradec, J., Kuch, J., McKelvie, R.S., McMurray, J.J.V., Michelson, E.L., Olofsson, B., Ostergren, J., Held, P., Solomon, S.D., Yusuf, S. and Swedberg, K.
Circulation 110
(17): 2618-2626.
1 January 2004
Regenerative capacity of the myocardium: implications for treatment of heart failure.
von Harsdorf, R., Poole-Wilson, P.A. and Dietz, R.
Lancet 363
: 1306-1313.
1 January 2004
Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation.
Dechend, R., Gieffers, J., Dietz, R., Joerres, A., Rupp, J., Luft, F.C. and Maass, M.
Circulation 108
(3): 261-265.
22 July 2003
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase.
Dechend, R., Viedt, C., Mueller, D.N., Ugele, B., Brandes, R.P., Wallukat, G., Park, J.K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J. and Luft, F.C.
Circulation 107
(12): 1632-1639.
1 April 2003
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
Geier, C., Perrot, A., Ozcelik, C., Binner, P., Counsell, D., Hoffmann, K., Pilz, B., Martiniak, Y., Gehmlich, K., van der Ven, P.F.M., Furst, D.O., Vornwald, A., von Hodenberg, E., Nuernberg, P., Scheffold, T., Dietz, R. and Osterziel, K.J.
Circulation 107
(10): 1390-1395.
18 March 2003
Blood oxygen level-dependent magnetic resonance imaging in patients with stress-induced angina.
Friedrich, M.G., Niendorf, T., Schulz-Menger, J., Gross, C.M. and Dietz, R.
Circulation 108
(18): 2219-2223.
1 January 2003
Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey.
Cleland, J.G.F., Cohen-Solal, A., Aguilar, J.C., Dietz, R., Eastaugh, J., Follath, F., Freemantle, N., Gavazzi, A., van Gilst, W.H., Hobbs, F.D.R., Korewicki, J., Madeira, H.C., Preda, I., Swedberg, K. and Widimsky, J.
Lancet 360
(9346): 1631-1639.
23 November 2002
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A))receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade trial (HEAT).
Luescher, T.F., Enseleit, F., Pacher, R., Mitrovic, V., Schulze, M.R., Willenbrock, R., Dietz, R., Rousson, V., Huerlimann, D., Philipp, S., Notter, T., Noll, G. and Ruschitzka, F.
Circulation 106
(21): 2666-2672.
19 November 2002
Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC.
Li, P.F., Li, J.C., Mueller, E.C., Otto, A., Dietz, R. and von Harsdorf, R.
Molecular Cell 10
(2): 247-258.
August 2002
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure - Results from 2 placebo-controlled studies.
Doehner, W., Schoene, N., Rauchhaus, M., Leyva-Leon, F., Pavitt, D.V., Reaveley, D.A., Schuler, G., Coats, A.J.S., Anker, S.D. and Hambrecht, R.
Circulation 105
(22): 2619-2624.
4 June 2002
Calcineurin in human heart hypertrophy.
Ritter, O., Hack, S., Schuh, K., Roethlein, N., Perrot, A., Osterziel, K.J., Schulte, H.D. and Neyses, L.
Circulation 105
(19): 2265-2269.
14 May 2002
Assessment of survival in patients with primary pulmonary hypertension importance of cardiopulmonary exercise testing.
Wensel, R., Opitz, C.F., Anker, S.D., Winkler, J., Hoffken, G., Kleber, F.X., Sharma, R., Hummel, M., Hetzer, R. and Ewert, R.
Circulation 106
(3): 319-324.
1 January 2002
MRI versus 3D echocardiography in postinterventional patients with hypertrophic obstructive cardiomyopathy - Response.
Schulz-Menger, J., Strohm, O., Waigand, J., Uhlich, F., Dietz, R. and Friedrich, M.G.
Circulation 104
: E32-E33.
14 August 2001
Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Dechend, R., Fiebeler, A., Park, J.K., Muller, D.N., Theuer, J., Mervaala, E., Bieringer, M., Gulba, D., Dietz, R., Luft, F.C. and Haller, H.
Circulation 104
: 576-581.
1 January 2001
In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Mehrhof, F.B., Mueller, F.U., Bergmann, M.W., Li, P.F., Wang, Y.B., Schmitz, W., Dietz, R. and von Harsdorf, R.
Circulation 104
: 2088-2094.
1 January 2001
Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance - Marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis.
Ponikowski, P., Francis, D.P., Piepoli, M.F., Davies, L.C., Chua, T.P., Davos, C.H., Florea, V., Banasiak, W., Poole-Wilson, P.A., Coats, A.J.S. and Anker, S.D.
Circulation 103
: 967-972.
1 January 2001
Peripheral chemoreceptor hypersensitivity - An ominous sign in patients with chronic heart failure.
Ponikowski, P., Chua, T.P., Anker, S.D., Francis, D.P., Doehner, W., Banasiak, W., Poole-Wilson, P.A., Piepoli, M.F. and Coats, A.J.S.
Circulation 104
(5): 544-549.
1 January 2001
Plasma Cytokine Parameters and Mortality in Patients with Chronic Heart Failure.
Rauchhaus, M., Doehner, W., Francis, D.P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H.D., Coats, A.J.S. and Anker, S.D.
Circulation 102
(25): 3060-3067.
19 December 2000
Severe mitral regurgitation after valve replacement as cause of pulmonary venous aneurysm.
Christow, S.P. and Dietz, R.
Circulation 102
(17): 2159-2160.
24 October 2000
The endotoxin-lipoprotein hypothesis.
Rauchhaus, M., Coats, A.J.S. and Anker, S.D.
Lancet 356
(9233): 930-933.
9 September 2000
AT1 receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor.
Dechend, R., Homuth, V., Wallukat, G., Kreuzer, J., Park, J.K., Theuer, J., Juepner, A., Gulba, D.C., Mackman, N., Haller, H. and Luft, F.C.
Circulation 101
: 2382-2387.
23 May 2000
The value of magnetic resonance imaging of the left ventricular outflow tract in patients with hypertrophic obstructive cardiomyopathy after septal artery embolization.
Schulz-Menger, J., Strohm, O., Waigand, J., Uhlich, F., Dietz, R. and Friedrich, M.G.
Circulation 101
: 1764-1766.
18 April 2000
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure - The metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF).
Hjalmarson, A., Goldstein, S., Fagerberg, B., Wedel, H., Waagstein, F., Kjekshus, J., Wikstrand, J., El Allaf, D., Vitovec, J., Aldershvile, J., Halinen, M., Dietz, R., Neuhaus, K.L., Janosi, A., Thorgeirsson, G., Dunselman, P.H.J.M., Gullestad, L., Kuch, J., Herlitz, J., Rickenbacher, P., Ball, S., Gottlieb, S. and Deedwania, P.
JAMA: Journal of the American Medical Association 283
(10): 1295-1302.
8 March 2000
Increased mortality associated with growth hormone treatment in critically ill adults.
Osterziel, K.J., Dietz, R. and Ranke, M.B.
New England Journal of Medicine 342
: 134-135.
13 January 2000
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.
Li, P.F., Dietz, R. and von Harsdorf, R.
EMBO Journal 18
(21): 6027-6036.
1 November 1999
Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22.
Jung, M., Poepping, I., Perrot, A., Ellmer, A.E., Wienker, T.F., Dietz, R., Reis, A. and Osterziel, K.J.
American Journal of Human Genetics 65
(4): 1068-1077.
October 1999
Coma in a park.
Pilz, B., Mesner, C., Baetgen, S. and Luft, F.C.
Lancet 354
: 1090.
25 September 1999
Endotoxin and immune activation in chronic heart failure: a prospective cohort study.
Niebauer, J., Volk, H.D., Kemp, M., Dominguez, M., Schumann, R.R., Rauchhaus, M., Poole-Wilson, P.A., Coats, A.J.S. and Anker, S.D.
Lancet 353
(9167): 1838-1842.
29 May 1999
The cardiac insufficiency bisoprolol study II (CIBIS-II): a randomised trial.
Lechat, P., Brunhuber, K.W., Hofmann, R. and Osterziel, K.J.
Lancet 353
(9146): 9-13.
2 January 1999
Insulin-like growth factor-I and risk of breast cancer.
Strohm, O., Osterziel, K.J. and Dietz, R.
Lancet 352
(9126): 489-489.
8 August 1998
Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy.
Osterziel, K.J., Strohm, O., Schuler, J., Friedrich, M., Haenlein, D., Willenbrock, R., Anker, S.D., Poole-Wilson, P.A., Ranke, M.B. and Dietz, R.
Lancet 351
(9111): 1233-1237.
25 April 1998
Traumatic ventricular aneurysm.
Jordan, J. and Dietz, R.
New England Journal of Medicine 336
(9): 625-625.
27 February 1997
Medical compared with surgical treatment for massive pulmonary embolism.
Gulba, D., Schmid, C., Borst, H.G., Lichtlen, P.R., Dietz, R. and Luft, F.C.
Lancet 343
(8897): 576-577.
5 March 1994
Dittmar, Gunnar
The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37
(24): e98658.
14 December 2018
Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M., Fan, D.N.Y., Belenki, D., Däbritz, J.H.M., Zhao, Z., Yu, Y., Dörr, J.R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G., Lee, S. and Schmitt, C.A.
Nature 553
(7686): 96-100.
4 January 2018
Translation of circRNAs.
Pamudurti, N.R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., Shenzis, S., Samson, M., Dittmar, G., Landthaler, M., Chekulaeva, M., Rajewsky, N. and Kadener, S.
Molecular Cell 66
(1): 9-21.
6 April 2017
Initiation of acute graft-versus-host disease by angiogenesis.
Riesner, K., Shi, Y., Jacobi, A., Kräter, M., Kalupa, M., McGearey, A., Mertlitz, S., Cordes, S., Schrezenmeier, J.F., Mengwasser, J., Westphal, S., Perez-Hernandez, D., Schmitt, C., Dittmar, G., Guck, J. and Penack, O.
Blood 129
(14): 2021-2032.
6 April 2017
Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice.
Viola, J.R., Lemnitzer, P., Jansen, Y., Csaba, G., Winter, C., Neideck, C., Silvestre-Roig, C., Dittmar, G., Doering, Y., Drechsler, M., Weber, C., Zimmer, R., Cenac, N. and Soehnlein, O.
Circulation Research 119
(9): 1030-1038.
14 October 2016
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
Weber, A., Cohen, I., Popp, O., Dittmar, G., Reiss, Y., Sommer, T., Ravid, T. and Jarosch, E.
Molecular Cell 63
(5): 827-839.
1 September 2016
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Bagola, K., von Delbrück, M., Dittmar, G., Scheffner, M., Ziv, I., Glickman, M.H., Ciechanover, A. and Sommer, T.
Molecular Cell 50
(4): 528-539.
23 May 2013
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Mueller-Rischart, A.K., Pilsl, A., Beaudette, P., Patra, M., Hadian, K., Funke, M., Peis, R., Deinlein, A., Schweimer, C., Kuhn, P.H., Lichtenthaler, S.F., Motori, E., Hrelia, S., Wurst, W, Truembach, D., Langer, T., Krappmann, D., Dittmar, G., Tatzelt, J. and Winklhofer, K.F.
Molecular Cell 49
(5): 908-921.
7 March 2013
Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.
Anton, F., Dittmar, G., Langer, T. and Escobar-Henriques, M.
Molecular Cell 49
(3): 487-498.
7 February 2013
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E.S.J., Wend, P., Purfürst, B., Nuber, U.A., Gurok, U., Matyash, V., Waelzlein, J.H., Chirasani, S.R., Dittmar, G., Cravatt, B.F., Momma, S., Lewin, G.R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H. and Glass, R.
Nature Medicine 18
(8): 1232-1238.
August 2012
Global quantification of mammalian gene expression control.
Schwanhaeusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W. and Selbach, M.
Nature 473
(7347): 337-342.
19 May 2011
A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
Pless, O., Kowenz-Leutz, E., Dittmar, G. and Leutz, A.
Nature Protocols 6
(3): 359-364.
February 2011
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz, M., Stilmann, M., Coel Arslan, S., Khanna, K.K., Dittmar, G. and Scheidereit, C.
Molecular Cell 40
(1): 63-74.
8 October 2010
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Stolz, A., Ertych, N., Kienitz, A., Vogel, C., Schneider, V., Fritz, B., Jacob, R., Dittmar, G., Weichert, W., Petersen, I. and Bastians, H.
Nature Cell Biology 12
(5): 492-499.
May 2010
Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E., Pless, O., Dittmar, G., Knoblich, M. and Leutz, A.
EMBO Journal 29
(6): 1105-1115.
17 March 2010
Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.
Wilkinson, C.R., Dittmar, G.A., Ohi, M.D., Uetz, P., Jones, N. and Finley, D.
Current Biology 14
: 2283-2288.
29 December 2004
Doerken, Bernd (MDC/ECRC)
Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M.S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dörken, B., Speck, C., Mallette, F.A., Zon, L.I., Holmen, S.L., Peeper, D.S., Samuels, Y., Schmitt, C.A. and Lee, S.
Cancer Cell 33
(2): 322-336.
12 February 2018
Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M., Fan, D.N.Y., Belenki, D., Däbritz, J.H.M., Zhao, Z., Yu, Y., Dörr, J.R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G., Lee, S. and Schmitt, C.A.
Nature 553
(7686): 96-100.
4 January 2018
Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D., Hummel, F., Richter, J., Giefing, M., Hartmann, S., Hansmann, M.L., Kreher, S., Köchert, K., Krappmann, D., Klapper, W., Hummel, M., Wenzel, S.S., Lenz, G., Janz, M., Dörken, B., Siebert, R. and Mathas, S.
Leukemia 31
(3): 602-613.
March 2017
Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes.
Pfeifer, M., Zheng, B., Erdmann, T., Koeppen, H., McCord, R., Grau, M., Staiger, A., Chai, A., Sandmann, T., Madle, H., Doerken, B., Chu, Y.W., Chen, A.I., Lebovic, D., Salles, G.A., Czuczman, M.S., Palanca-Wessels, M.C., Press, O.W., Advani, R., Morschhauser, F., Cheson, B.D., Lenz, P., Ott, G., Polson, A.G., Mundt, K.E. and Lenz, G.
Leukemia 29
(7): 1578-1586.
July 2015
Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial.
Pelzer, U., Opitz, B., Deutschinoff, G., Stauch, M., Reitzig, P.C., Hahnfeld, S., Mueller, L., Grunewald, M., Stieler, J.M., Sinn, M., Denecke, T., Bischoff, S., Oettle, H., Doerken, B. and Riess, H.
Journal of Clinical Oncology 33
(18): 2028-2034.
20 June 2015
The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.
Ullrich, K., Blumenthal-Barby, F., Lamprecht, B., Koechert, K., Lenze, D., Hummel, M., Mathas, S., Doerken, B. and Janz, M.
Leukemia 29
(5): 1213-1218.
May 2015
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A., Grau, M., Erdmann, T., Merkel, O., Sobhiafshar, U., Anagnostopoulos, I., Hummel, M., Siegert, A., Hayford, C., Madle, H., Wollert-Wulf, B., Fichtner, I., Dörken, B., Dirnhofer, S., Mathas, S., Janz, M., Emre, N.C.T., Rosenwald, A., Ott, G., Lenz, P., Tzankov, A. and Lenz, G.
Blood 125
(1): 124-132.
1 January 2015
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial.
Oettle, H., Riess, H., Stieler, J.M., Heil, G., Schwaner, I., Seraphin, J., Goerner, M., Moelle, M., Greten, T.F., Lakner, V., Bischoff, S., Sinn, M., Doerken, B. and Pelzer, U.
Journal of Clinical Oncology 32
(23): 2423-2429.
10 August 2014
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R., Frick, M., Romero, R., Korn, J.M., Kridel, R., Chun Chan, F., Meissner, B., Bhang, H.E., Ruddy, D., Kauffmann, A., Farsidjani, A., Derti, A., Rakiec, D., Naylor, T., Pfister, E., Kovats, S., Kim, S., Dietze, K., Doerken, B., Steidl, C., Tzankov, A., Hummel, M., Monahan, J., Morrissey, M.P., Fritsch, C., Sellers, W.R., Cooke, V.G., Gascoyne, R.D., Lenz, G. and Stegmeier, F.
Nature Medicine 20
(1): 87-92.
January 2014
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Nagel, D., Spranger, S., Vincendeau, M., Grau, M., Raffegerst, S., Kloo, B., Hlahla, D., Neuenschwander, M., von Kries, J.P., Hadian, K., Doerken, B., Lenz, P., Lenz, G., Schendel, D.J. and Krappmann, D.
Cancer Cell 22
(6): 825-837.
11 December 2012
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37
(5): 854-866.
16 November 2012
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P., Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K., Sleckman, B.P., de Alboran, I.M., Janz, M., Rodig, S. and Rajewsky, K.
Nature Immunology 13
(11): 1092-1100.
November 2012
Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
Engert, A., Haverkamp, H., Kobe, C., Markova, J., Renner, C., Ho, A., Zijlstra, J., Kral, Z., Fuchs, M., Hallek, M., Kanz, L., Doehner, H., Doerken, B., Engel, N., Topp, M., Klutmann, S., Amthauer, H., Bockisch, A., Kluge, R., Kratochwil, C., Schober, O., Greil, R., Andreesen, R., Kneba, M., Pfreundschuh, M., Stein, H., Eich, H.T., Mueller, R.P., Dietlein, M., Borchmann, P. and Diehl, V.
Lancet 379
(9828): 1791-1799.
12 May 2012
Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Schwarzer, R., Doerken, B. and Jundt, F.
Leukemia 26
(4): 806-813.
April 2012
NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia.
Terwey, T.H., Vega-Ruiz, A., Hemmati, P.G., Martus, P., Dietz, E., le Coutre, P., Massenkeil, G., Doerken, B. and Arnold, R.
Leukemia 26
(3): 536-542.
March 2012
Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group.
Borchmann, P., Haverkamp, H., Diehl, V., Cerny, T., Markova, J., Ho, A.D., Eich, H.T., Mueller-Hermelink, H.K., Kanz, L., Greil, R., Rank, A., Paulus, U., Smardova, L., Huber, C., Doerken, B., Nerl, C., Krause, S.W., Mueller, R.P., Fuchs, M. and Engert, A.
Journal of Clinical Oncology 29
(32): 4234-4342.
10 November 2011
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Doerken, B., Lenz, G., Scheidereit, C., Schmitt, C.A. and Lee, S.
Genes & Development 25
(20): 2137-2146.
15 October 2011
Severe peripheral arterial disease during nilotinib therapy.
Le Coutre, P., Rea, D., Abruzzese, E., Dombret, H., Trawinska, M.M., Herndlhofer, S., Doerken, B. and Valent, P.
Journal of the National Cancer Institute 103
(17): 1347-1348.
7 September 2011
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger, A., Moebs, M., Ullmann, R., Koechert, K., Kreher, S., Lamprecht, B., Anagnostopoulos, I., Hummel, M., Richter, J., Beyer, M., Janz, M., Klemke, C.D., Stein, H., Doerken, B., Sterry, W., Schrock, E., Mathas, S. and Assaf, C.
Journal of Experimental Medicine 208
(8): 1585-1593.
1 August 2011
Pathogenesis of non-Hodgkin's lymphoma.
Nogai, H., Doerken, B. and Lenz, G.
Journal of Clinical Oncology 29
(14): 1803-1811.
10 May 2011
Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Eich, H.T., Diehl, V., Goergens, H., Pabst, T., Markova, J., Debus, J., Ho, A., Doerken, B., Rank, A., Grosu, A.L., Wiegel, T., Karstens, J.H., Greil, R., Willich, N., Schmidberger, H., Doehner, H., Borchmann, P., Mueller-Hermelink, H.K., Mueller, R.P. and Engert, A.
Journal of Clinical Oncology 28
(27): 4199-4206.
20 September 2010
Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert, A., Pluetschow, A., Eich, H.T., Lohri, A., Doerken, B., Borchmann, P., Berger, B., Greil, R., Willborn, K.C., Wilhelm, M., Debus, J., Eble, M.J., Soekler, M., Ho, A., Rank, A., Ganser, A., Truemper, L., Bokemeyer, C., Kirchner, H., Schubert, J., Kral, Z., Fuchs, M., Mueller-Hermelink, H.K., Mueller, R.P. and Diehl, V.
New England Journal of Medicine 363
(7): 640-652.
12 August 2010
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Koechert, K., Bouhlel, M.A., Richter, J., Soler, E., Stadhouders, R., Joehrens, K., Wurster, K.D., Callen, D.F., Harte, M.F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., Cockerill, P.N., Siebert, R., Doerken, B., Bonifer, C. and Mathas, S.
Nature Medicine 16
(5): 571-579, 1p following 579.
May 2010
Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J.R., Tabor, V., Aichele, P., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17
(3): 262-272.
16 March 2010
C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K., Bégay, V., Smink, J.J., Zaragoza, K., Wiesenthal, V., Doerken, B., Calkhoven, C.F. and Leutz, A.
Genes & Development 24
(1): 15-20.
1 January 2010
The dangers of transcription.
Mathas, S. and Misteli, T.
Cell 139
(6): 1047-1049.
11 December 2009
C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R., Janz, M., Galson, D.L., Gries, M., Li, S., Johrens, K., Anagnostopoulos, I., Doerken, B., Mapara, M.Y., Borghesi, L., Kardava, L., Roodman, G.D., Milcarek, C. and Lentzsch, S.
Blood 114
(18): 3890-3898.
29 October 2009
Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Engert, A., Diehl, V., Franklin, J., Lohri, A., Doerken, B., Ludwig, W.D., Koch, P., Haenel, M., Pfreundschuh, M., Wilhelm, M., Truemper, L., Aulitzky, W.E., Bentz, M., Rummel, M., Sezer, O., Mueller-Hermelink, H.K., Hasenclever, D. and Loeffler, M.
Journal of Clinical Oncology 27
(27): 4548-4554.
20 September 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B., Kreher, S., Anagnostopoulos, I., Joehrens, K., Monteleone, G., Jundt, F., Stein, H., Janz, M., Doerken, B. and Mathas, S.
Blood 112
(8): 3339-3347.
15 October 2008
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann, M., Loddenkemper, C., Rudolph, C., Schildhauer, I., Teichmann, B., Stein, H., Schlegelberger, B., Doerken, B. and Schmitt, C.A.
Blood 110
(8): 2996-3004.
15 October 2007
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109
(3): 886-895.
1 February 2007
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
Oettle, H., Post, S., Neuhaus, P., Gellert, K., Langrehr, J., Ridwelski, K., Schramm, H., Fahlke, J., Zuelke, C., Burkart, C., Gutberlet, K., Kettner, E., Schmalenberg, H., Weigang-Koehler, K., Bechstein, W.O., Niedergethmann, M., Schmidt-Wolf, I., Roll, L., Doerken, B. and Riess, H.
JAMA: Journal of the American Medical Association 297
(3): 267-277.
17 January 2007
STAT3 and MAPK signaling maintains overexpression of the heat shock proteins 90a and b in multiple myeloma cells, which critically contribute to tumor cell survival.
Chatterjee, M., Jain, S., Stuehmer, T., Andrulis, M., Ungethuem, U., Kuban, R.J., Lorentz, H., Bommert, K., Topp, M., Kramer, D., Mueller-Hermelink, H. K., Einsele, H., Greiner, A. and Bargou, R.C.
Blood 109
(2): 720-728.
15 January 2007
Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma.
Martin-Subero, J.I., Wlodarska, I., Bastard, C., Picquenot, J.M., Hoeppner, J., Giefing, M., Klapper, W., Siebert, R., Mathas, S., Joos, S., Stein, H. and Doerken, B.
Blood 108
: 401-403.
1 July 2006
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells.
Janz, M., Hummel, M., Truss, M., Wollert-Wulf, B., Mathas, S., Joehrens, K., Hagemeier, C., Bommert, K., Stein, H., Doerken, B. and Bargou, R.C.
Blood 107
(6): 2536-2539.
15 March 2006
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7
(2): 207-215.
February 2006
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S., Joehrens, K., Joos, S., Lietz, A., Hummel, F., Janz, M., Jundt, F., Anagnostopoulos, I., Bommert, K., Lichter, P., Stein, H., Scheidereit, C. and Doerken, B.
Blood 106
(13): 4287-4293.
25 August 2005
Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A.H., Schlegelberger, B., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Nature 436
(7051): 660-665.
4 August 2005
Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R.A., Daniel, P.T., Bommert, K., Vassilev, L.T. and Bargou, R.C.
Blood 106
: 3609-3617.
4 August 2005
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Ding, Q., Xia, W., Liu, J.C., Yang, J.Y., Lee, D.F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., Bargou, R.C., Qin, J., Lai, C.C., Tsai, F.J., Tsai, C.H. and Hung, M.C.
Molecular Cell 19
: 159-170.
1 January 2005
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F., Raetzel, N., Mueller, C., Calkhoven, C.F., Kley, K., Mathas, S., Lietz, A., Leutz, A. and Doerken, B.
Blood 106
: 1801-1807.
1 January 2005
Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R., Janz, M., Mapara, M.Y., Lemke, B., Stirling, D., Doerken, B., Zenke, M. and Lentzsch, S.
Blood 105
(10): 3833-3840.
1 January 2005
Stroma-mediated dysregulation of myelopoiesis in mice lacking IkappaBalpha.
Rupec, R.A., Jundt, F., Rebholz, B., Eckelt, B., Weindl, G.N., Herzinger, T., Flaig, M.J., Moosmann, S., Plewig, G., Doerken, B., Foerster, I., Huss, R. and Pfeffer, K.
Immunity 22
: 479-491.
1 January 2005
Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study.
Thuss-Patience, P.C., Kretzschmar, A., Repp, M., Kingreen, D., Hennesser, D., Micheel, S., Pink, D., Scholz, C., Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 23
: 494-501.
1 January 2005
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.
Mathas, S., Lietz, A., Anagnostopoulos, I., Hummel, F., Wiesner, B., Janz, M., Jundt, F., Hirsch, B., Joehrens-Leder, K., Vornlocher, H.P., Bommert, K., Stein, H. and Doerken, B.
Journal of Experimental Medicine 199
(8): 1041-1052.
19 April 2004
Cellular senescence in cancer treatment: friend or foe?
Kahlem, P., Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113
(2): 169-174.
January 2004
Extravasations of oxaliplatin.
Kretzschmar, A., Pink, D., Thuss-Patience, P., Doerken, B., Reichert, P. and Eckert, R.
Journal of Clinical Oncology 21
(21): 4068-4069.
1 November 2003
Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B., Sturm, I., Lage, H., Berger, S., Schneider, U., Haupfmann, S., Wust, P., Riess, H., Schlag, P.M., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21
(18): 3391-3401.
15 September 2003
Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S., Lietz, A., Janz, M., Hinz, M., Jundt, F., Scheidereit, C., Bommert, K. and Doerken, B.
Blood 102
(3): 1028-1034.
1 August 2003
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B., Essmann, F., Graupner, V., Staerck, L., Radetzki, S., Doerken, B., Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22
(14): 3580-3590.
15 July 2003
Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkins disease.
Diehl, V., Franklin, J., Pfreundschuh, M., Lathan, B., Paulus, U., Hasenclever, D., Tesch, H., Herrmann, R., Doerken, B., Mueller-Hermelink, H.K., Duehmke, E. and Loeffler, M.
New England Journal of Medicine 348
(24): 2386-2395.
12 June 2003
Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S., Gries, M., Janz, M., Bargou, R., Doerken, B. and Mapara, M.Y.
Blood 101
(9): 3568-3573.
1 May 2003
Acute hypokalemic tetraparesis induced by intravenous methotrexate.
Thuss-Patience, P.C., Peters, U., Jurkat-Rott, K., Pink, D., Kretzschmar, A., Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 21
(9): 1896-1897.
1 May 2003
Chemotherapy response and resistance.
Lee, S. and Schmitt, C.A.
Current Opinion in Genetics & Development 13
(1): 90-96.
February 2003
Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196
(5): 605-617.
2 September 2002
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S., Hinz, M., Anagnostopoulos, L., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dörken, B. and Scheidereit, C.
EMBO Journal 21
(15): 4104-4113.
1 August 2002
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M. and Lowe, S.W.
Cell 109
(3): 335-346.
3 May 2002
Antisense therapy in oncology: new hope for an old idea?
Tamm, I., Doerken, B. and Hartmann, G.
Lancet 358
(9280): 489-497.
11 August 2001
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
Rehm, A., Stern, P., Ploegh, H.L. and Tortorella, D.
EMBO Journal 20
(7): 1573-1582.
2 April 2001
A role for beta2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response.
Walzog, B., Weinmann, P., Jeblonski, F., Scharffetter-Kochanek, K., Bommert, K. and Gaehtgens, P.
FASEB Journal 13
(13): 1855-1865.
October 1999
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.
Bargou, R.C., Juerchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M.Y., Winzer, K.J., Dietel, M., Doerken, B. and Royer, H.D.
Nature Medicine 3
: 447-450.
1 January 1997
Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in scid mice.
Bargou, R.C., Wagener, C., Bommert, K., Arnold, W., Daniel, P.T., Mapara, M.Y., Grinstein, E., Royer, H.D. and Doerken, B.
Journal of Experimental Medicine 183
(3): 1205-1213.
1 March 1996
Characterization of a novel Hodgkin cell-line, HD-MyZ, HD-Myr, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.
Bargou, R.C., Mapara, M.Y., Zugck, C., Daniel, P.T., Pawlita, M., Doehner, H. and Doerken, B.
Journal of Experimental Medicine 177
(5): 1257-1268.
1 May 1993
Dörr, Jan Rafael (ECRC)
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung, K.L., Jones, M.G., Wong, I.T.L., Curtis, E.J., Lange, J.T., He, B.J., Luebeck, J., Schmargon, R., Scanu, E., Brückner, L., Yan, X., Li, R., Gnanasekar, A., Chamorro González, R., Belk, J.A., Liu, Z., Melillo, B., Bafna, V., Dörr, J.R., Werner, B., Huang, W., Cravatt, B.F., Henssen, A.G., Mischel, P.S and Chang, H.Y.
Nature 635
(8037): 201-209.
7 November 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K., Kase, J., Dörr, J.R., Trescher, S., Bhattacharya, A., Yu, Y., Wailes, E.M., Fan, D.N.Y., Lohneis, P., Milanovic, M., Lau, A., Lenze, D., Hummel, M., Chapuy, B., Leser, U., Reimann, M., Lee, S. and Schmitt, C.A.
Nature Communications 11
(1): 3651.
20 July 2020
Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M., Fan, D.N.Y., Belenki, D., Däbritz, J.H.M., Zhao, Z., Yu, Y., Dörr, J.R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G., Lee, S. and Schmitt, C.A.
Nature 553
(7686): 96-100.
4 January 2018
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Doerken, B., Lenz, G., Scheidereit, C., Schmitt, C.A. and Lee, S.
Genes & Development 25
(20): 2137-2146.
15 October 2011
Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J.R., Tabor, V., Aichele, P., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17
(3): 262-272.
16 March 2010
Falcke, Martin
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M.J. and Bock, A.
Cell 185
(7): 1130-1142.e11.
31 March 2022
On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
Schreiber, C., Amiri, B., Heyn, J.C.J., Rädler, J.O. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 118
(4): e2009959118.
26 January 2021
Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts.
Stegbauer, J., Kraus, M., Nordmeyer, S., Kirchner, M., Ziehm, M., Dommisch, H., Kelle, S., Kelm, M., Baczko, I., Landmesser, U., Tschope, C., Knosalla, C., Falcke, M., Schapranow, M.P., Regitz-Zagrosek, V., Mertins, P. and Kuehne, T.
Hypertension 76
(6): e41-e43.
December 2020
The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D., Formichetti, S., Junker, J.P., Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16
(11): e9946.
1 November 2020
Optical mapping of cAMP signaling at the nanometer scale.
Bock, A., Annibale, P., Konrad, C., Hannawacker, A., Anton, S.E., Maiellaro, I., Zabel, U., Sivaramakrishnan, S., Falcke, M. and Lohse, M.J.
Cell 182
(6): 1519-1530.
17 September 2020
Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling.
Zhang, J.Z., Lu, T.W., Stolerman, L.M., Tenner, B., Yang, J.R., Zhang, J.F., Falcke, M., Rangamani, P., Taylor, S.S., Mehta, S. and Zhang, J.
Cell 182
(6): 1531-1544.
17 September 2020
Long-term effects of Na(+)/Ca(2+) exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Primessnig, U., Bracic, T., Levijoki, J., Otsomaa, L., Pollesello, P., Falcke, M., Pieske, B. and Heinzel, F.R.
European Journal of Heart Failure 21
(12): 1543-1552.
December 2019
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9
(1): 2161.
4 June 2018
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Taufiq-Ur-Rahman, Skupin, A., Falcke, M. and Taylor, C.W.
Nature 458
(7238): 655-659.
2 April 2009
Falk, Kirsten
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119
(22): 2904-2912.
9 June 2009
A xenon-129 biosensor for monitoring MHC-peptide interactions.
Schlundt, A., Kilian, W., Beyermann, M., Sticht, J., Guenther, S., Hoepner, S., Falk, K., Roetzschke, O., Mitschang, L. and Freund, C.
Angewandte Chemie International Edition 48
(23): 4142-4145.
25 May 2009
In vivo-activated CD103+ Foxp3+ Tregs: of men and mice.
Roetzschke, O., Borsellino, G., Battistini, L., Falk, K. and Kleinewietfeld, M.
Blood 113
(9): 2119-2120.
26 February 2009
CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells.
Kleinewietfeld, M., Starke, M., Mitri, D.D., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 113
(4): 827-836.
22 January 2009
Hydrolysis of extracellular ATP by CD39+ Treg cells: context matters!
Kleinewietfeld, M., Dimitri, D., Sternjak, A., Diamantini, A., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 111
(2): 965-966.
15 January 2008
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.
Borsellino, G., Kleinewietfeld, M., Di Mitri, D., Sternjak, A., Diamantini, A., Giometto, R., Hoepner, S., Centonze, D., Bernardi, G., Dell'Acqua, M.L., Rossini, P.M., Battistini, L., Roetzschke, O. and Falk, K.
Blood 110
(4): 1225-1232.
15 August 2007
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W.
Nature Immunology 7
(4): 392-400.
April 2006
CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset.
Kleinewietfeld, M., Puentes, F., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 105
(7): 2877-2886.
1 January 2005
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Roetzschke, O., Lau, J.M., Hofstätter, M., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 99
(26): 16946-16950.
24 December 2002
The final cut: how ERAP1 trims MHC ligands to size.
Falk, K. and Roetzschke, O.
Nature Immunology 3
(12): 1121-1122.
December 2002
Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope.
Stienekemeier, M., Falk, K., Roetzschke, O., Weishaupt, A., Schneider, C., Toyka, K.V., Gold, R. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13872-13877.
1 November 2001
Fichtner, Iduna
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly.
Belz, K., Schoeneberger, H., Wehner, S., Weigert, A., Boenig, H., Klingebiel, T., Fichtner, I. and Fulda, S.
Blood 124
(2): 240-250.
10 July 2014
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U., Walther, W., Scudiero, D., Selby, M., Kobelt, D., Lemm, M., Fichtner, I., Schlag, P.M., Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103
(13): 1018-1036.
6 July 2011
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F.H., Stein, U., Fichtner, I., Schlag, P.M. and Birchmeier, W.
Gastroenterology 137
(11): 165-175.
July 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15
(1): 59-67.
January 2009
Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo.
Schadendorf, D., Kern, M.A., Artuc, M., Pahl, H.L., Rosenbach, T., Fichtner, I., Nuernberg, W., Stueting, S., von Stebut, E., Worm, M., Makki, A., Jurgovsky, K., Kolde, G. and Henz, B.M.
Journal of Cell Biology 135
(6 Pt 2): 1889-1898.
December 1996
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.
Stein, U., Walther, W. and Shoemaker, R.H.
Journal of the National Cancer Institute 88
: 1383-1392.
1 January 1996
Fielitz, Jens (ECRC)
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
(6): 1653-1668.
December 2021
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13
(1): 713-727.
February 2021
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11
(1): 103-119.
February 2020
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187
(4): 387-396.
15 February 2013
Forslund, Sofia (MDC/ECRC)
Antibiotic-perturbed microbiota and the role of probiotics.
Szajewska, H., Scott, K.P., de Meij, T., Forslund-Startceva, S.K., Knight, R., Koren, O., Little, P., Johnston, B.C., Łukasik, J., Suez, J., Tancredi, D.J. and Sanders, M.E.
Nature Reviews Gastroenterology & Hepatology
11 December 2024
(In Press)
Bifidobacterium and lactobacillus probiotics and gut dysbiosis in preterm infants: the PRIMAL randomized clinical trial.
Van Rossum, T., Haiß, A., Knoll, R.L., Marißen, J., Podlesny, D., Pagel, J., Bleskina, M., Vens, M., Fortmann, I., Siller, B., Ricklefs, I., Klopp, J., Hilbert, K., Meyer, C., Thielemann, R., Goedicke-Fritz, S., Kuntz, M., Wieg, C., Teig, N., Körner, T., Kribs, A., Hudalla, H., Knuf, M., Stein, A., Gille, C., Bagci, S., Dohle, F., Proquitté, H., Olbertz, D.M., Schmidt, E., Koch, L., Pirr, S., Rupp, J., Spiegler, J., Kopp, M.V., Göpel, W., Herting, E., Forslund, S.K., Viemann, D., Zemlin, M., Bork, P., Gehring, S., König, I.R., Henneke, P. and Härtel, C.
JAMA Pediatrics 178
(10): 985-995.
October 2024
A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies.
Wirbel, J., Essex, M., Forslund, S.K. and Zeller, G.
Genome Biology 25
(1): 247.
25 September 2024
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15
(1): 2788.
30 March 2024
Rigorous science demands support of transgender scientists.
Aghi, K., Anderson, B.M., Castellano, B.M., Cunningham, A., Delano, M., Dickinson, E.S., von Diezmann, L., Forslund-Startceva, S.K., Grijseels, D.M., Groh, S.S., Guthman, E.M., Jayasinghe, I., Johnston, J., Long, S., McLaughlin, J.F., McLaughlin, M., Miyagi, M., Rajaraman, B., Sancheznieto, F., Scheim, A.I., Sun, S.E.D., Titmuss, F.D., Walsh, R.J. and Weinberg, Z.Y.
Cell 187
(6): 1327-1334.
14 March 2024
Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease.
Essex, M., Rios Rodriguez, V., Rademacher, J., Proft, F., Löber, U., Marko, L., Pleyer, U., Strowig, T., Marchand, J., Kirwan, J.A., Siegmund, B., Forslund, S.K. and Poddubnyy, D.
Arthritis & Rheumatology 76
(1): 48-58.
January 2024
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S.K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J.E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M.T., Hoyles, L., Alves, R., Helft, G., Isnard, R., Køber, L., Coelho, L.P., Rouault, C., Gauguier, D., Gøtze, J.P., Prifti, E., Froguel, P., Zucker, J.D., Bäckhed, F., Vestergaard, H., Hansen, T., Oppert, J.M., Blüher, M., Nielsen, J., Raes, J., Bork, P., Yaqoob, M.M., Stumvoll, M., Pedersen, O., Ehrlich, S.D., Clément, K. and Dumas, M.E.
Nature Communications 14
(1): 5843.
20 September 2023
The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.
Schoeler, M., Ellero-Simatos, S., Birkner, T., Mayneris-Perxachs, J., Olsson, L., Brolin, H., Löber, U., Kraft, J.D., Polizzi, A., Martí-Navas, M., Puig, J., Moschetta, A., Montagner, A., Gourdy, P., Heymes, C., Guillou, H., Tremaroli, V., Fernández-Real, J.M., Forslund, S.K., Burcelin, R. and Caesar, R.
Nature Communications 14
(1): 5329.
1 September 2023
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs?
Bengtsson-Palme, J., Abramova, A., Berendonk, T.U., Coelho, L.P., Forslund, S.K., Gschwind, R., Heikinheimo, A., Jarquín-Díaz, V.H., Khan, A.A., Klümper, U., Löber, U., Nekoro, M., Osińska, A.D., Ugarcina Perovic, S., Pitkänen, T., Rødland, E.K., Ruppé, E., Wasteson, Y., Wester, A.L. and Zahra, R.
Environment International 178
: 108089.
5 July 2023
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Samuelsson, A.M., Bartolomaeus, T.U.P., Anandakumar, H., Thowsen, I., Nikpey, E., Han, J., Marko, L., Finne, K., Tenstad, O., Eckstein, J., Berndt, N., Kühne, T., Kedziora, S., Sultan, I., Skogstrand, T., Karlsen, T.V., Nurmi, H., Forslund, S.K., Bollano, E., Alitalo, K., Muller, D.N. and Wiig, H.
Cardiovascular Research 119
(7): 1553-1567.
4 July 2023
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
The effect of probiotic and synbiotic supplementation on lipid parameters among patients with cardiometabolic risk factors: a systematic review and meta-analysis of clinical trials.
Ghorbani, Z., Kazemi, A., Bartolomaeus, T.U.P., Martami, F., Noormohammadi, M., Salari, A., Löber, U., Balou, H.A., Forslund, S.K. and Mahdavi-Roshan, M.
Cardiovascular Research 119
(4): 933-956.
April 2023
The gut microbiota in multiple sclerosis varies with disease activity.
Thirion, F., Sellebjerg, F., Fan, Y., Lyu, L., Hansen, T.H., Pons, N., Levenez, F., Quinquis, B., Stankevic, E., Søndergaard, H.B., Dantoft, T.M., Poulsen, C.S., Forslund, S.K., Vestergaard, H., Hansen, T., Brix, S., Oturai, A., Sørensen, P.S., Ehrlich, S.D. and Pedersen, O.
Genome Medicine 15
(1): 1.
5 January 2023
Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host.
Midha, A., Jarquín-Díaz, V.H., Ebner, F., Löber, U., Hayani, R., Kundik, A., Cardilli, A., Heitlinger, E., Forslund, S.K. and Hartmann, S.
Microbiome 10
(1): 229.
16 December 2022
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K.E., Prifiti, E., Aron-Wisnewsky, J., Debédat, J., Le Roy, T., Nielsen, T., Amouyal, C., André, S., Andreelli, F., Blüher, M., Chakaroun, R., Chilloux, J., Coelho, L.P., Dao, M.C., Das, P., Fellahi, S., Forslund, S., Galleron, N., Hansen, T.H., Holmes, B., Ji, B., Krogh Pedersen, H., Le, P., Le Chatelier, E., Lewinter, C., Mannerås-Holm, L., Marquet, F., Myridakis, A., Pelloux, V., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Sokolovska, N., Søndertoft, N.B., Touch, S., Vieira-Silva, S., Galan, P., Holst, J., Gøtze, J.P., Køber, L., Vestergaard, H., Hansen, T., Hercberg, S., Oppert, J.M., Nielsen, J., Letunic, I., Dumas, M.E., Stumvoll, M., Pedersen, O.B., Bork, P., Ehrlich, S.D., Zucker, J.D., Bäckhed, F., Raes, J. and Clément, K.
Gut 71
(12): 2463-2480.
7 November 2022
Antibiotic resistance genes in river biofilms: a metagenomic approach toward the identification of sources and candidate hosts.
Kneis, D., Berendonk, T.U., Forslund, S.K. and Hess, S.
Environmental Science and Technology 56
(21): 14913-14922.
1 November 2022
Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S., Smyshlyaev, G., Letunic, I., Maistrenko, O.M., Coelho, L.P., Orakov, A., Forslund, S.K., Hildebrand, F., Luetge, M., Schmidt, T.S.B., Barabas, O. and Bork, P.
Nucleic Acids Research 50
(6): 3155-3168.
8 April 2022
Microbiome and metabolome features of the cardiometabolic disease spectrum.
Fromentin, S., Forslund, S.K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M.T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R., Coelho, L.P., Falony, G., Fellahi, S., Galan, P., Galleron, N., Helft, G., Hoyles, L., Isnard, R., Le Chatelier, E., Julienne, H., Olsson, L., Pedersen, H.K., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Schmidt, T.S.B., Vieira-Silva, S., Li, P., Zimmermann-Kogadeeva, M., Lewinter, C., Søndertoft, N.B., Hansen, T.H., Gauguier, D., Gøtze, J.P., Køber, L., Kornowski, R., Vestergaard, H., Hansen, T., Zucker, J.D., Hercberg, S., Letunic, I., Bäckhed, F., Oppert, J.M., Nielsen, J., Raes, J., Bork, P., Stumvoll, M., Segal, E., Clément, K., Dumas, M.E., Ehrlich, S.D. and Pedersen, O.
Nature Medicine 28
(2): 303-314.
17 February 2022
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
Talmor-Barkan, Y., Bar, N., Shaul, A.A., Shahaf, N., Godneva, A., Bussi, Y., Lotan-Pompan, M., Weinberger, A., Shechter, A., Chezar-Azerrad, C., Arow, Z., Hammer, Y., Chechi, K., Forslund, S.K., Fromentin, S., Dumas, M.E., Ehrlich, S.D., Pedersen, O., Kornowski, R. and Segal, E.
Nature Medicine 28
(2): 295-302.
February 2022
Towards the biogeography of prokaryotic genes.
Coelho, L.P., Alves, R., Del Río, Á.R., Myers, P.N., Cantalapiedra, C.P., Giner-Lamia, J., Schmidt, T.S., Mende, D.R., Orakov, A., Letunic, I., Hildebrand, F., Van Rossum, T., Forslund, S.K., Khedkar, S., Maistrenko, O.M., Pan, S., Jia, L., Ferretti, P., Sunagawa, S., Zhao, X.M., Nielsen, H.B., Huerta-Cepas, J. and Bork, P.
Nature 601
(7892): 252-256.
13 January 2022
Combinatorial, additive and dose-dependent drug-microbiome associations.
Forslund, S.K., Chakaroun, R., Zimmermann-Kogadeeva, M., Markó, L., Aron-Wisnewsky, J., Nielsen, T., Moitinho-Silva, L., Schmidt, T.S.B., Falony, G., Vieira-Silva, S., Adriouch, S., Alves, R.J., Assmann, K., Bastard, J.P., Birkner, T., Caesar, R., Chilloux, J., Coelho, L.P., Fezeu, L., Galleron, N., Helft, G., Isnard, R., Ji, B., Kuhn, M., Le Chatelier, E., Myridakis, A., Olsson, L., Pons, N., Prifti, E., Quinquis, B., Roume, H., Salem, J.E., Sokolovska, N., Tremaroli, V., Valles-Colomer, M., Lewinter, C., Søndertoft, N.B., Pedersen, H.K., Hansen, T.H., Gøtze, J.P., Køber, L., Vestergaard, H., Hansen, T., Zucker, J.D., Hercberg, S., Oppert, J.M., Letunic, I., Nielsen, J., Bäckhed, F., Ehrlich, S.D., Dumas, M.E., Raes, J., Pedersen, O., Clément, K., Stumvoll, M. and Bork, P.
Nature 600
: 500-505.
16 December 2021
Unravelling the collateral damage of antibiotics on gut bacteria.
Maier, L., Goemans, C.V., Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., Garcia-Santamarina, S., Cacace, E., Zhang, B., Gekeler, C., Banerjee, T., Anderson, E.E., Milanese, A., Löber, U., Forslund, S.K., Patil, K.R., Zimmermann, M., Stecher, B., Zeller, G., Bork, P. and Typas, A.
Nature 599
: 120-124.
4 November 2021
Reporting guidelines for human microbiome research: the STORMS checklist.
Mirzayi, C., Renson, A., Zohra, F., Elsafoury, S., Geistlinger, L., Kasselman, L.J., Eckenrode, K., van de Wijgert, J., Loughman, A., Marques, F.Z., MacIntyre, D.A., Arumugam, M., Azhar, R., Beghini, F., Bergstrom, K., Bhatt, A., Bisanz, J.E., Braun, J., Bravo, H.C., Buck, G.A., Bushman, F., Casero, D., Clarke, G., Collado, M.C., Cotter, P.D., Cryan, J.F., Demmer, R.T., Devkota, S., Elinav, E., Escobar, J.S., Fettweis, J., Finn, R.D., Fodor, A.A., Forslund, S., Franke, A., Furlanello, C., Gilbert, J., Grice, E., Haibe-Kains, B., Handley, S., Herd, P., Holmes, S., Jacobs, J.P., Karstens, L., Knight, R., Knights, D., Koren, O., Kwon, D.S., Langille, M., Lindsay, B., McGovern, D., McHardy, A.C., McWeeney, S., Mueller, N.T., Nezi, L., Olm, M., Palm, N., Pasolli, E., Raes, J., Redinbo, M.R., Rühlemann, M., Balfour Sartor, R, Schloss, P.D., Schriml, L., Segal, E., Shardell, M., Sharpton, T., Smirnova, E., Sokol, H., Sonnenburg, J.L., Srinivasan, S., Thingholm, L.B., Turnbaugh, P.J., Upadhyay, V., Walls, R.L., Wilmes, P., Yamada, T., Zeller, G., Zhang, M., Zhao, N., Zhao, L., Bao, W., Culhane, A., Devanarayan, V., Dopazo, J., Fan, X., Fischer, M., Jones, W., Kusko, R., Mason, C.E., Mercer, T.R., Sansone, S.A., Scherer, A., Shi, L., Thakkar, S., Tong, W., Wolfinger, R., Hunter, C., Segata, N., Huttenhower, C., Dowd, J.B., Jones, H.E. and Waldron, L.
Nature Medicine 27
(11): 1885-1892.
November 2021
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Brial, F., Chilloux, J., Nielsen, T., Vieira-Silva, S., Falony, G., Andrikopoulos, P., Olanipekun, M., Hoyles, L., Djouadi, F., Neves, A.L., Rodriguez-Martinez, A., Mouawad, G.I., Pons, N., Forslund, S., Le-Chatelier, E., Le Lay, A., Nicholson, J., Hansen, T., Hyötyläinen, T., Clément, K., Oresic, M., Bork, P., Ehrlich, S.D., Raes, J., Pedersen, O.B., Gauguier, D. and Dumas, M.E.
Gut 70
(11): 2105-2114.
7 October 2021
Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
Carley, L.N., Mojica, J.P., Wang, B., Chen, C.Y., Lin, Y.P., Prasad, K.V.S.K, Chan, E., Hsu, C.W., Keith, R., Nuñez, C.L., Olson-Manning, C.F., Rushworth, C.A., Wagner, M.R., Wang, J., Yeh, P.M., Reichelt, M., Ghattas, K., Gershenzon, J., Lee, C.R. and Mitchell-Olds, T.
Nature Ecology & Evolution 5
: 1135-1144.
August 2021
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144
(2): 144-158.
13 July 2021
STEM pride: perspectives from transgender, nonbinary, and genderqueer scientists.
Armada-Moreira, A., Cizauskas, C., Fleury, G., Forslund, S.K., Guthman, E.M., Hanafiah, A., Hope, J.M., Jayasinghe, I., McSweeney, D. and Young, I.D.
Cell 184
(13): 3352-3355.
24 June 2021
Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E., Schewe, J., Zhang, J., Dinh, H.A., Forslund, S.K., Markó, L., Hellmig, N., Peters, J., Muller, D.N., Lifton, R.P., Nottoli, T., Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118
(17): e2014876118.
27 April 2021
The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K. and Muller, D.N.
Circulation Research 128
(7): 934-950.
2 April 2021
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12
(1): 1970.
30 March 2021
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
(3): 863-875.
1 March 2021
S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants.
Willers, M., Ulas, T., Völlger, L., Vogl, T., Heinemann, A.S., Pirr, S., Pagel, J., Fehlhaber, B., Halle, O., Schöning, J., Schreek, S., Löber, U., Essex, M., Hombach, P., Graspeuntner, S., Basic, M., Bleich, A., Cloppenborg-Schmidt, K., Künzel, S., Jonigk, D., Rupp, J., Hansen, G., Förster, R., Baines, J.F., Härtel, C., Schultze, J.L., Forslund, S.K., Roth, J. and Viemann, D.
Gastroenterology 159
(6): 2130-2145.
December 2020
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P.O., Rouault, C., André, S., Marquet, F., Andreelli, F., Salem, J.E., Assmann, K., Bastard, J.P., Forslund, S., Le Chatelier, E., Falony, G., Pons, N., Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T.H., Pedersen, H.K., Lewinter, C., Sønderskov, N.B., Køber, L., Vestergaard, H., Hansen, T., Zucker, J.D., Galan, P., Dumas, M.E., Raes, J., Oppert, J.M., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S.D., Stumvoll, M., Pedersen, O., Aron-Wisnewsky, J., Clément, K. and Bäckhed, F.
Nature Communications 11
(1): 5881.
18 November 2020
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H., Avery, E.G., Bartolomaeus, T.U.P., Kozhakhmetov, S., Zhumadilov, Z., Müller, D.N., Wilck, N., Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116
(7): 1252-1253.
June 2020
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Vieira-Silva, S., Falony, G., Belda, E., Nielsen, T., Aron-Wisnewsky, J., Chakaroun, R., Forslund, S.K., Assmann, K., Valles-Colomer, M., Nguyen, T..D., Proost, S., Prifti, E., Tremaroli, V., Pons, N., Le Chatelier, E., Andreelli, F., Bastard, J.P., Coelho, L.P., Galleron, N., Hansen, T.H., Hulot, J.S., Lewinter, C., Pedersen, H.K., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Søndertoft, N.B., Touch, S., Dumas, M.E., Ehrlich, S.D., Galan, P., Gøtze, J.P., Hansen, T., Holst, J.J., Køber, L., Letunic, I., Nielsen, J., Oppert, J.M., Stumvoll, M., Vestergaard, H., Zucker, J.D., Bork, P., Pedersen, O., Bäckhed, F., Clément, K. and Raes, J.
Nature 581
(7808): 310-315.
21 May 2020
B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116
(5): 1059-1070.
1 April 2020
Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G.I., Eilers, E., Bader, V., Haase, S., Kaisler, J., David, C., Schneider, R., Troisi, R., Zent, D., Hegelmaier, T., Dokalis, N., Gerstein, S., Del Mare-Roumani, S., Amidror, S., Staszewski, O., Poschmann, G., Stühler, K., Hirche, F., Balogh, A., Kempa, S., Träger, P., Zaiss, M.M., Holm, J.B., Massa, M.G., Nielsen, H.B., Faissner, A., Lukas, C., Gatermann, S.G., Scholz, M., Przuntek, H., Prinz, M., Forslund, S.K., Winklhofer, K.F., Müller, D.N., Linker, R.A., Gold, R. and Haghikia, A.
Cell 180
(6): 1067-1080.
19 March 2020
Hitchhiker's guide to microbiome studies.
Bartolomaeus, T.U.P. and Forslund, S.K.
Cardiovascular Research 116
(3): e44-e47.
1 March 2020
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Mende, D.R., Letunic, I., Maistrenko, O.M., Schmidt, T.S.B., Milanese, A., Paoli, L., Hernández-Plaza, A., Orakov, A.N., Forslund, S.K., Sunagawa, S., Zeller, G., Huerta-Cepas, J., Coelho, L.P. and Bork, P.
Nucleic Acids Research 48
(D1): D621-D625.
8 January 2020
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Schewe, J., Seidel, E., Forslund, S., Marko, L., Peters, J., Muller, D.N., Fahlke, C., Stölting, G. and Scholl, U.
Nature Communications 10
(1): 5155.
14 November 2019
Advances and applications in the quest for orthologs.
Glover, N., Dessimoz, C., Ebersberger, I., Forslund, S.K., Gabaldón, T., Huerta-Cepas, J., Martin, M.J., Muffato, M., Patricio, M., Pereira, C., Sousa da Silva, A., Wang, Y., Sonnhammer, E. and Thomas, P.D.
Molecular Biology and Evolution 36
(10): 2157-2164.
October 2019
Antibiotics-induced monodominance of a novel gut bacterial order.
Hildebrand, F., Moitinho-Silva, L., Blasche, S., Jahn, M.T.T., Gossmann, T.I., Heuerta Cepas, J., Hercog, R., Luetge, M., Bahram, M., Pryszlak, A., Alves, R.J., Waszak, S.M., Zhu, A., Ye, L., Costea, P.I., Aalvink, S., Belzer, C., Forslund, S.K., Sunagawa, S., Hentschel, U., Merten, C., Patil, K.R., Benes, V. and Bork, P.
Gut 68
(10): 1781-1790.
9 September 2019
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Huerta-Cepas, J., Szklarczyk, D., Heller, D., Hernández-Plaza, A., Forslund, S.K., Cook, H., Mende, D.R., Letunic, I., Rattei, T., Jensen, L.J., von Mering, C. and Bork, P.
Nucleic Acids Research 47
(D1): D309-D314.
8 January 2019
A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links.
Pedersen, H.K., Forslund, S.K., Gudmundsdottir, V., Petersen, A.Ø., Hildebrand, F., Hyötyläinen, T., Nielsen, T., Hansen, T., Bork, P., Ehrlich, S.D., Brunak, S., Oresic, M., Pedersen, O. and Nielsen, H.B.
Nature Protocols 13
(12): 2781-2800.
December 2018
Recovery of gut microbiota of healthy adults following antibiotic exposure.
Palleja, A., Mikkelsen, K.H., Forslund, S.K., Kashani, A., Allin, K.H., Nielsen, T., Hansen, T.H., Liang, S., Feng, Q., Zhang, C., Pyl, P.T., Coelho, L.P., Yang, H., Wang, J., Typas, A., Nielsen, M.F., Nielsen, H.B., Bork, P., Wang, J., Vilsbøll, T., Hansen, T., Knop, F.K., Arumugam, M. and Pedersen, O.
Nature Microbiology 3
: 1255-1265.
November 2018
Structure and function of the global topsoil microbiome.
Bahram, M., Hildebrand, F., Forslund, S.K., Anderson, J.L., Soudzilovskaia, N.A., Bodegom, P.M., Bengtsson-Palme, J., Anslan, S., Coelho, L.P., Harend, H., Huerta-Cepas, J., Medema, M.H., Maltz, M.R., Mundra, S., Olsson, P.A., Pent, M., Põlme, S., Sunagawa, S., Ryberg, M., Tedersoo, L. and Bork, P.
Nature 560
(7717): 233-237.
9 August 2018
Similarity of the dog and human gut microbiomes in gene content and response to diet.
Coelho, L.P., Kultima, J.R., Costea, P.I., Fournier, C., Pan, Y., Czarnecki-Maulden, G., Hayward, M.R., Forslund, S.K., Schmidt, T.S.B., Descombes, P., Jackson, J.R., Li, Q. and Bork, P.
Microbiome 6
(1): 72.
19 April 2018
Transposase-DNA complex structures reveal mechanisms for conjugative transposition of antibiotic resistance.
Rubio-Cosials, A., Schulz, E.C., Lambertsen, L., Smyshlyaev, G., Rojas-Cordova, C., Forslund, K., Karaca, E., Bebel, A., Bork, P. and Barabas, O.
Cell 173
(1): 208-220.
22 March 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Fast genome-wide functional annotation through orthology assignment by eggNOG-mapper.
Huerta-Cepas, J., Forslund, K., Coelho, L.P., Szklarczyk, D., Jensen, L.J., von Mering, C. and Bork, P.
Molecular Biology and Evolution 34
(8): 2115-2122.
1 August 2017
proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
Mende, D.R., Letunic, I., Huerta-Cepas, J., Li, S.S., Forslund, K., Sunagawa, S. and Bork, P.
Nucleic Acids Research 45
(D1): D529-D534.
4 January 2017
Human gut microbes impact host serum metabolome and insulin sensitivity.
Pedersen, H.K., Gudmundsdottir, V., Nielsen, H.B., Hyotylainen, T., Nielsen, T., Jensen, B.A.H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D.R., Pöhö, P., Hellgren, L.I., Arumugam, M., Sunagawa, S., Vieira-Silva, S., Jørgensen, T., Holm, J.B., Trošt, K., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Oresic, M., Ehrlich, S.D. and Pedersen, O.
Nature 535
(7612): 376-381.
21 July 2016
Standardized benchmarking in the quest for orthologs.
Altenhoff, A.M., Boeckmann, B., Capella-Gutierrez, S., Dalquen, D.A., DeLuca, T., Forslund, K., Huerta-Cepas, J., Linard, B., Pereira, C., Pryszcz, L.P., Schreiber, F., da Silva, A.S., Szklarczyk, D., Train, C.M., Bork, P., Lecompte, O., von Mering, C., Xenarios, I., Sjölander, K., Jensen, L.J., Martin, M.J., Muffato, M., Gabaldón, T., Lewis, S.E., Thomas, P.D., Sonnhammer, E. and Dessimoz, C.
Nature Methods 13
(5): 425-430.
May 2016
eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Huerta-Cepas, J., Szklarczyk, D., Forslund, K., Cook, H., Heller, D., Walter, M.C., Rattei, T., Mende, D.R., Sunagawa, S., Kuhn, M., Jensen, L.J., von Mering, C. and Bork, P.
Nucleic Acids Research 44
(D1): D286-D293.
4 January 2016
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K., Hildebrandt, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., Pedersen, H.K., Arumugam, M., Kristiansen, K., Voigt, A.Y., Vestergaard, H., Hercog, R., Costea, P.I., Kultima, J.R., Li, J., Jørgensen, T., Levenez, F., Dore, J., Nielsen, H.B., Brunak, S., Raes, J., Hansen, T., Wang, J., Ehrlich, S.D., Bork, P. and Pedersen, O.
Nature 528
(7581): 262-266.
10 December 2015
Ganten, Detlev
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs, R.A., Weinstock, G.M., Metzker, M.L., Muzny, D.M., Sodergren, E.J., Scherer, S., Scott, G., Steffen, D., Worley, K.C., Burch, P.E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R., Holt, R.A., Adams, M.D., Amanatides, P.G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans, C.A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C.L., Nguyen, T., Pfannkoch, C.M., Sitter, C., Sutton, G.G., Venter, J.C., Woodage, T., Smith, D., Lee, H.M., Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss, R.B., Dunn, D.M., Green, E.D., Blakesley, R.W., Bouffard, G.G., de Jong, P.J., Osoegawa, K., Zhu, B., Marra, M., Schein, J., Bosdet, I., Fjell, C., Jones, S., Krzywinski, M., Mathewson, C., Siddiqui, A., Wye, N., McPherson, J., Zhao, S., Fraser, C.M., Shetty, J., Shatsman, S., Geer, K., Chen, Y., Abramzon, S., Nierman, W.C., Havlak, P.H., Chen, R., Durbin, K.J., Egan, A., Ren, Y., Song, X.Z., Li, B., Liu, Y., Qin, X., Cawley, S., Worley, K.C., Cooney, A.J., D'Souza, L.M., Martin, K., Wu, J.Q., Gonzalez-Garay, M.L., Jackson, A.R., Kalafus, K.J., McLeod, M.P., Milosavljevic, A., Virk, D., Volkov, A., Wheeler, D.A., Zhang, Z., Bailey, J.A., Eichler, E.E., Tuzun, E., Birney, E., Mongin, E., Ureta-Vidal, A., Woodwark, C., Zdobnov, E., Bork, P., Suyama, M., Torrents, D., Alexandersson, M., Trask, B.J., Young, J.M., Huang, H., Wang, H., Xing, H., Daniels, S., Gietzen, D., Schmidt, J., Stevens, K., Vitt, U., Wingrove, J., Camara, F., Alba, M.M., Abril, J.F., Guigo, R., Smit, A., Dubchak, I., Rubin, E.M., Couronne, O., Poliakov, A., Hübner, N., Ganten, D., Goesele, C., Hummel, O., Kreitler, T., Lee, Y.A., Monti, J., Schulz, H., Zimdahl, H., Himmelbauer, H., Lehrach, H., Jacob, H.J., Bromberg, S., Gullings-Handley, J., Jensen-Seaman, M.I., Kwitek, A.E., Lazar, J., Pasko, D., Tonellato, P.J., Twigger, S., Ponting, C.P., Duarte, J.M., Rice, S., Goodstadt, L., Beatson, S.A., Emes, R.D., Winter, E.E., Webber, C., Brandt, P., Nyakatura, G., Adetobi, M., Chiaromonte, F., Elnitski, L., Eswara, P., Hardison, R.C., Hou, M., Kolbe, D., Makova, K., Miller, W., Nekrutenko, A., Riemer, C., Schwartz, S., Taylor, J., Yang, S., Zhang, Y., Lindpaintner, K., Andrews, T.D., Caccamo, M., Clamp, M., Clarke, L., Curwen, V., Durbin, R., Eyras, E., Searle, S.M., Cooper, G.M., Batzoglou, S., Brudno, M., Sidow, A., Stone, E.A., Venter, J.C., Payseur, B.A., Bourque, G., Lopez-Otin, C., Puente, X.S., Chakrabarti, K., Chatterji, S., Dewey, C., Pachter, L., Bray, N., Yap, V.B., Caspi, A., Tesler, G., Pevzner, P.A., Haussler, D., Roskin, K.M., Baertsch, R., Clawson, H., Furey, T.S., Hinrichs, A.S., Karolchik, D., Kent, W.J., Rosenbloom, K.R., Trumbower, H., Weirauch, M., Cooper, D.N., Stenson, P.D., Ma, B., Brent, M., Arumugam, M., Shteynberg, D., Copley, R.R., Taylor, M.S., Riethman, H., Mudunuri, U., Peterson, J., Guyer, M., Felsenfeld, A., Old, S., Mockrin, S. and Collins, F.
Nature 428
(6982): 493-521.
1 April 2004
Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome.
Krzywinski, M., Wallis, J., Gösele, C., Bosdet, I., Chiu, R., Graves, T., Hummel, O., Layman, D., Mathewson, C., Wye, N., Zhu, B., Albracht, D., Asano, J., Barber, S., Brown-John, M., Chan, S., Chand, S., Cloutier, A., Davito, J., Fjell, C., Gaige, T., Ganten, D., Girn, N., Guggenheimer, K., Himmelbauer, H., Kreitler, T., Leach, S., Lee, D., Lehrach, H., Mayo, M., Mead, K., Olson, T., Pandoh, P., Prabhu, A.L., Shin, H., Taenzer, S., Thompson, J., Tsai, M., Walker, J., Yang, G., Sekhon, M., Hillier, L., Zimdahl, H., Marziali, A., Osoegawa, K., Zhao, S., Siddiqui, A., de Jong, P.J., Warren, W., Mardis, E., McPherson, J.D., Wilson, R., Hübner, N., Jones, S., Marra, M. and Schein, J.
Genome Research 14
(4): 766-779.
April 2004
A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H., Nyakatura, G., Brandt, P., Schulz, H., Hummel, O., Fartmann, B., Brett, D., Droege, M., Monti, J., Lee, Y.A., Sun, Y.Y., Zhao, S.Y., Winter, E.E., Ponting, C.P., Chen, Y., Kasprzyk, A., Birney, E., Ganten, D. and Hubner, N.
Science 303
(5659): 807-807.
1 January 2004
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning.
Faendrich, F., Lin, X., Chai, G.X., Schulze, M., Ganten, D., Bader, M., Holle, J., Huang, D.S., Parwaresch, R., Zavazava, N. and Binas, B.
Nature Medicine 8
: 171-178.
1 February 2002
Sequence interpretation - Functional annotation of mouse genome sequences.
Nadeau, J.H., Balling, R., Barsh, G., Beier, D., Brown, S.D.M., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L., Hicks, G., de Angelis, M.H., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A.M., Rinchik, E.M., Rossant, J., Russell, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W. and Zimmer, A.
Science 291
: 1251-1255.
1 January 2001
Distinguished scientists back Germany's DFG . .
Jahn, R., Boeck, A., Breiner, K.M., Breunig, K.D., Bujard, H., Campos-Ortega, J., Ganten, D., Grummt, I., Gruss, P., Goridis, C., Huber, R., Hoch, M., Jaeckle, H., Kahmann, R., Koch-Brandt, C., Leptin, M., Michel, H., Noegel, A., Neher, E., Nuesslein-Volhard, C., Pfanner, N., Sandhoff, K., Schoen, A., Schwille, P., Simons, K. and Zrenner, E.
Nature 404
: 922-922.
27 April 2000
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.
Schinke, M., Baltatu, O., Boehm, M., Peters, J., Rascher, W., Bricca, G., Lippoldt, A., Ganten, D. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 3975-3980.
30 March 1999
Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease.
Rubattu, S., Volpe, M., Kreutz, R., Ganten, U., Ganten, D. and Lindpaintner, K.
Nature Genetics 13
: 429-434.
1 January 1996
Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.
Kreutz, R., Hübner, N., James, M.R., Bihoreau, M.T., Gauguier, D., Lathrop, G.M., Ganten, D. and Lindpaintner, K.
Proceedings of the National Academy of Sciences of the United States of America 92
(19): 8778-8782.
12 September 1995
Role of adrenal renin in the regulation of adrenal steroidogenesis corticotropin.
Sander, M., Ganten, D. and Mellon, S.H.
Proceedings of the National Academy of Sciences of the United States of America 91
(1): 148-152.
4 January 1994
Transgenic rats: new experimental models for the study of candidate genes in hypertension research.
Paul, M., Wagner, J., Hoffmann, S., Urata, H. and Ganten, D.
Annual Review of Physiology 56
: 811-829.
1994
Gargiulo, Gaetano
Cell states in cancer: drivers, passengers, and trailers.
Gargiulo, G., Serresi, M. and Marine, J.C.
Cancer Discovery 14
(4): 610-614.
4 April 2024
Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho, I.L., Li, C.Y., Wang, F., Zhao, L., Liu, J., Yen, E.Y., Dyke, C.A., Shah, R., Liu, Z., Çetin, A.O., Chu, Y., Citron, F., Attanasio, S., Corti, D., Darbaniyan, F., Del Poggetto, E., Loponte, S., Liu, J., Soeung, M., Chen, Z., Jiang, S., Jiang, H., Inoue, A., Gao, S., Deem, A., Feng, N., Ying, H., Kim, M., Giuliani, V., Genovese, G., Zhang, J., Futreal, A., Maitra, A., Heffernan, T., Wang, L., Do, K.A., Gargiulo, G., Draetta, G., Carugo, A., Lin, R. and Viale, A.
Science Advances 10
(11): eadd9342.
15 March 2024
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
Company, C., Schmitt, M.J., Dramaretska, Y., Serresi, M., Kertalli, S., Jiang, B., Yin, J.A., Aguzzi, A., Barozzi, I. and Gargiulo, G.
Nature Communications 15
(1): 897.
5 February 2024
Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses.
Jiang, B., Schmitt, M.J., Rand, U., Company, C., Dramaretska, Y., Grossmann, M., Serresi, M., Cicin-Sain, L. and Gargiulo, G.
Science Advances 9
(25): eadf4975.
23 June 2023
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13
(1): 6867.
11 November 2022
Cannabidiol converts NF(κ)B into a tumor suppressor in glioblastoma with defined antioxidative properties.
Volmar, M.N.M., Cheng, J., Alenezi, H., Richter, S., Haug, A., Hassan, Z., Goldberg, M., Li, Y., Hou, M., Herold-Mende, C., Maire, C.L., Lamszus, K., Flüh, C., Held-Feindt, J., Gargiulo, G., Topping, G.J., Schilling, F., Saur, D., Schneider, G., Synowitz, M., Schick, J.A., Kälin, R.E. and Glass, R.
Neuro-Oncology 23
(11): 1898-1910.
November 2021
Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J., Company, C., Dramaretska, Y., Barozzi, I., Göhrig, A., Kertalli, S., Großmann, M., Naumann, H., Sánchez-Bailón, M.P., Hulsman, D., Glass, R., Squatrito, M., Serresi, M. and Gargiulo, G.
Cancer Discovery 11
(3): 754-777.
March 2021
Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M., Kertalli, S., Li, L., Schmitt, M.J., Dramaretska, Y., Wierikx, J., Hulsman, D. and Gargiulo, G.
Science Advances 7
(9): eabd7974.
24 February 2021
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Serresi, M., Siteur, B., Hulsman, D., Company, C., Schmitt, M.J., Lieftink, C., Morris, B., Cesaroni, M., Proost, N., Beijersbergen, R.L., van Lohuizen, M. and Gargiulo, G.
Journal of Experimental Medicine 215
(12): 3115.
3 December 2018
SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
Ferone, G., Song, J.Y., Sutherland, K.D., Bhaskaran, R., Monkhorst, K., Lambooij, J.P., Proost, N., Gargiulo, G. and Berns, A.
Cancer Cell 30
(4): 519-532.
10 October 2016
Garratt, Alistair N.
Notch signaling is essential for ventricular chamber development.
Grego-Bessa, J., Luna-Zurita, L., del Monte, G., Bolos, V., Melgar, P., Arandilla, A., Garratt, A.N., Zang, H., Mukouyama, Y.S., Chen, H., Shou, W., Ballestar, E., Esteller, M., Rojas, A., Perez-Pomares, J.M. and de la Pompa, J.L.
Developmental Cell 12
(3): 415-429.
March 2007
Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., Destrooper, B., Saftig, P., Birchmeier, C. and Haass, C.
Science 314
(5799): 664-666.
27 October 2006
Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lopez-Bendito, G., Cautinat, A., Sanchez, J.A., Bielle, F., Flames, N., Garratt, A.N., Talmage, D.A., Role, L.W., Charnay, P., Marin, O. and Garel, S.
Cell 125
(1): 127-142.
7 April 2006
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Flames, N., Long, J.E., Garratt, A.N., Fischer, T.M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J.L. and Marin, O.
Neuron 44
(2): 251-261.
14 October 2004
Met provides essential signals for liver regeneration.
Borowiak, M., Garratt, A.N., Wuestefeld, T., Strehle, M., Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101
(29): 10608-10613.
1 January 2004
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool.
Garratt, A.N., Voiculescu, O., Topilko, P., Charnay, P. and Birchmeier, C.
Journal of Cell Biology 148
(5): 1035-1046.
6 March 2000
Geier, Christian (ECRC)
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F., Haas, J., Zhu, F., Geier, C., Kayvanpour, E., Liss, M., Lai, A., Frese, K., Pribe-Wolferts, R., Amr, A., Li, D.T., Samani, O.S., Carstensen, A., Bordalo, D.M., Müller, M., Fischer, C., Shao, J., Wang, J., Nie, M., Yuan, L., Haßfeld, S., Schwartz, C., Zhou, M., Zhou, Z., Shu, Y., Wang, M., Huang, K., Zeng, Q., Cheng, L., Fehlmann, T., Ehlermann, P., Keller, A., Dieterich, C., Streckfuß-Bömeke, K., Liao, Y., Gotthardt, M., Katus, H.A. and Meder, B.
European Heart Journal 38
(46): 3449-3460.
7 December 2017
Subacute coronary stent thrombosis in cancer patients.
Gross, C.M., Posch, M.G., Geier, C., Olthoff, H., Kraemer, J., Dechend, R., Dietz, R. and Oezcelik, C.
Journal of the American College of Cardiology 51
(12): 1232-1233.
25 March 2008
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
Geier, C., Perrot, A., Ozcelik, C., Binner, P., Counsell, D., Hoffmann, K., Pilz, B., Martiniak, Y., Gehmlich, K., van der Ven, P.F.M., Furst, D.O., Vornwald, A., von Hodenberg, E., Nuernberg, P., Scheffold, T., Dietz, R. and Osterziel, K.J.
Circulation 107
(10): 1390-1395.
18 March 2003
Gerhardt, Holger
Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135
(6): 671-684.
30 August 2024
External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction.
Mehl, J., Farahani, S.K., Brauer, E., Klaus-Bergmann, A., Thiele, T., Ellinghaus, A., Bartels-Klein, E., Koch, K., Schmidt-Bleek, K., Petersen, A., Gerhardt, H., Vogel, V. and Duda, G.N.
Advanced Science 11
(13): e2307050.
3 April 2024
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong, Y.T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A.S.H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., Lim, J., Watanabe, S., Guenther, S., Schneider, A., Zanconato, F., Kaulich, M., Pan, D., Braun, T., Gerhardt, H., Efeyan, A., Carmeliet, P., Piccolo, S., Grosso, A.R. and Potente, M.
Nature Metabolism 4
(6): 672-682.
June 2022
Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance.
Guérit, S., Fidan, E., Macas, J., Czupalla, C.J., Figueiredo, R., Vijikumar, A., Yalcin, B.H., Thom, S., Winter, P., Gerhardt, H., Devraj, K. and Liebner, S.
Progress in Neurobiology 199
: 101937.
April 2021
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80
(6): 1316-1329.
March 2020
ATTRACT: arterial flow as attractor for endothelial cell migration.
Georgieva, P.B., Marchuk, D.A. and Gerhardt, H.
Circulation Research 125
(3): 262-264.
July 2019
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A., Alt, S., Ferreira, R.M.M., Gribben, C., Wang, V.M.Y., Cotoi, C.G., Salbreux, G. and Behrens, A.
Nature 566
(7742): 126-130.
7 February 2019
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Angulo-Urarte, A., Casado, P., Castillo, S.D., Kobialka, P., Kotini, M.P., Figueiredo, A.M., Castel, P., Rajeeve, V., Milà-Guasch, M., Millan, J., Wiesner, C., Serra, H., Muixi, L., Casanovas, O., Viñals, F., Affolter, M., Gerhardt, H., Huveneers, S., Belting, H.G., Cutillas, P.R. and Graupera, M.
Nature Communications 9
(1): 4826.
16 November 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Mathivet, T., Bouleti, C., Van Woensel, M., Stanchi, F., Verschuere, T., Phng, L.K., Dejaegher, J., Balcer, M., Matsumoto, K., Georgieva, P.B., Belmans, J., Sciot, R., Stockmann, C., Mazzone, M., De Vleeschouwer, S. and Gerhardt, H.
EMBO Molecular Medicine 9
(12): 1629-1645.
1 December 2017
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Elling, U., Wimmer, R.A., Leibbrandt, A., Burkard, T., Michlits, G., Leopoldi, A., Micheler, T., Abdeen, D., Zhuk, S., Aspalter, I.M., Handl, C., Liebergesell, J., Hubmann, M., Husa, A.M., Kinzer, M., Schuller, N., Wetzel, E., van de Loo, N., Martinez, J.A.Z., Estoppey, D., Riedl, R., Yang, F., Fu, B., Dechat, T., Ivics, Z., Agu, C.A., Bell, O., Blaas, D., Gerhardt, H., Hoepfner, D., Stark, A. and Penninger, J.M.
Nature 550
(7674): 114-118.
5 October 2017
The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V., Birdsey, G.M., Peghaire, C., Pitulescu, M.E., Dufton, N.P., Yang, Y., Weinberg, I., Osuna Almagro, L., Payne, L., Mason, J.C., Gerhardt, H., Adams, R.H. and Randi, A.M.
Nature Communications 8
: 16002.
11 July 2017
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
Pericytes or mesenchymal stem cells: is that the question?
Cano, E., Gebala, V. and Gerhardt, H.
Cell Stem Cell 20
(3): 296-297.
2 March 2017
Glycolytic regulation of cell rearrangement in angiogenesis.
Cruys, B., Wong, B.W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., Merks, R.M.H., Dejana, E., Gerhardt, H., Dewerchin, M., Bentley, K. and Carmeliet, P.
Nature Communications 7
: 12240.
20 July 2016
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Gebala, V., Collins, R., Geudens, I., Phng, L.K. and Gerhardt, H.
Nature Cell Biology 18
(4): 443-450.
April 2016
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M.F., Lim, R., Zimmermann, B., Aspalter, I.M., Franco, C.A., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K., Keller, C., Brüning, J.C., Gerhardt, H., Carmeliet, P. and Potente, M.
Nature 529
(7585): 216-220.
14 January 2016
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Vinals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M.
Nature Communications 6
: 7935.
31 July 2015
Wiring the vascular network with neural cues: a CNS perspective.
Waächli, T., Wacker, A., Frei, K., Regli, L., Schwab, M.E., Hoerstrup, S.P., Gerhardt, H. and Engelhardt, B.
Neuron 87
(2): 271-296.
15 July 2015
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Aspalter, I.M., Gordon, E., Dubrac, A., Ragab, A., Narloch, J., Vizán, P., Geudens, I., Collins, R.T., Franco, C.A., Abrahams, C.L., Thurston, G., Fruttiger, M., Rosewell, I., Eichmann, A. and Gerhardt, H.
Nature Communications 6
: 7264.
17 June 2015
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K.C.S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A.R., Christen, S., Goveia, J., Heggermont, W., Goddé, L., Vinckier, S., Van Veldhoven, P.P., Eelen, G., Schoonjans, L., Gerhardt, H., Dewerchin, M., Baes, M., De Bock, K., Ghesquière, B., Lunt, S.Y., Fendt, S.M. and Carmeliet, P.
Nature 520
(7546): 192-197.
9 April 2015
Gerull, Brenda
Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.
Heuser, A., Plovie, E.R., Ellinor, P.T., Grossmann, K.S., Shin, J.T., Wichter, T., Basson, C.T., Lerman, B.B., Sasse-Klaassen, S., Thierfelder, L., MacRae, C.A. and Gerull, B.
American Journal of Human Genetics 79
(6): 1081-1088.
December 2006
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S., Probst, S., Gerull, B., Oechslin, E., Nuernberg, P., Heuser, A., Jenni, R., Hennies, H.C. and Thierfelder, L.
Circulation 109
(22): 2720-2723.
8 June 2004
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Gerull, B., Gramlich, M., Atherton, J., McNabb, M., Trombitas, K., Sasse-Klaassen, S., Seidman, J.G., Seidman, C., Granzier, H., Labeit, S., Frenneaux, M. and Thierfelder, L.
Nature Genetics 30
(2): 201-204.
February 2002
Gollasch, Maik (ECRC)
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J., Luong, T.T., Tuffaha, R., Musculus, K., Auer, T., Lian, X., Daniel, C., Zickler, D., Boehme, B., Sacherer, M., Metzler, B., Kuhl, D., Gollasch, M., Amann, K., Müller, D.N., Pieske, B., Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128
(7): 3024-3040.
2 July 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S.M.A., van het Hof, B., Gollasch, M., Drexhage, J.A.R., Reijerkerk, A., Meij, I.C., Mebius, R., Willnow, T.E., Müller, D., Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128
(2): 267-277.
August 2014
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J., Kassmann, M., Szijártó, I.A., Hercule, H.C., Tano, J.Y., Weinert, S., Heidenreich, M., Pathan, A.R., Anistan, Y.M., Alenina, N., Rusch, N.J., Bader, M., Jentsch, T.J. and Gollasch, M.
Circulation Research 115
(2): 263-272.
7 July 2014
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C., Seniuk, A., Sokolov, M.V., Huebner, A.K., Klementowicz, A.E., Szijártó, I.A., Schleifenbaum, J., Vitzthum, H., Gollasch, M., Ehmke, H., Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124
(2): 675-686.
3 February 2014
BK channels in innate immune functions of neutrophils and macrophages.
Essin, K., Gollasch, M., Rolle, S., Weissgerber, P., Sausbier, M., Bohn, E., Autenrieth, I.B., Ruth, P., Luft, F.C., Nauseef, W.M. and Kettritz, R.
Blood 113
(6): 1326-1331.
5 February 2009
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.
Sausbier, M., Arntz, C., Bucurenciu, I., Zhao, H., Zhou, X.B., Sausbier, U., Feil, S., Kamm, S., Essin, K., Sailer, C.A., Abdullah, U., Krippeit-Drews, P., Feil, R., Hofmann, F., Knaus, H.G., Kenyon, C., Shipston, M.J., Storm, J.F., Neuhuber, W., Korth, M., Schubert, R., Gollasch, M. and Ruth, P.
Circulation 112
: 60-68.
5 July 2005
Paracrine role for periadventitial adipose tissue in the regulation of arterial tone.
Gollasch, M. and Dubrovska, G.
Trends in Pharmacological Sciences 25
: 647-653.
1 December 2004
Gossen, Manfred
Studying gene function in eukaryotes by conditional gene inactivation.
Gossen, M. and Bujard, H.
Annual Review of Genetics 36
: 153-173.
December 2002
Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T., Kammertoens, T., Preiss, S., Debs, P., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194
(12): 1767-1775.
17 December 2001
Gotthardt, Michael
SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction.
Gotthardt, M. and Lehnart, S.E.
Cardiovascular Research 120
(3): 220-222.
February 2024
Cardiac splicing as a diagnostic and therapeutic target.
Gotthardt, M., Badillo Lisakowski, V., Parikh, V.N., Ashley, E., Furtado, M., Carmo-Fonseca, M., Schudy, S., Meder, B., Grosch, M., Steinmetz, L., Crocini, C. and Leinwand, L.
Nature Reviews Cardiology 20
(8): 517-530.
August 2023
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J., Rodríguez-Martínez, M., Fenzl, K., Hinze, F., Schraivogel, D., Grosch, M., Tunaj, B., Lindenhofer, D., Schraft, L., Kueblbeck, M., Smith, E., Mao, C., Brown, E., Owens, A., Saguner, A.M., Meder, B., Parikh, V., Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14
(1): 4312.
18 July 2023
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M., Schraft, L., Chan, A., Küchenhoff, L., Rapti, K., Ferreira, A.M., Kornienko, J., Li, S., Radke, M.H., Krämer, C., Clauder-Münster, S., Perlas, E., Backs, J., Gotthardt, M., Dieterich, C., van den Hoogenhof, M.M.G., Grimm, D. and Steinmetz, L.M.
Nature Communications 14
(1): 3714.
22 June 2023
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83
(6): 994-1011.e18.
16 March 2023
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13
(1): 6407.
27 October 2022
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82
(11): 2069-2083.
2 June 2022
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H., Major, J.L., Liebner, T., Hourani, Z., Travers, J.G., Wennersten, S.A., Haefner, K.R., Cavasin, M.A., Wilson, C.E., Jeong, M.Y., Han, Y., Gotthardt, M., Ferguson, S.K., Ambardekar, A.V., Lam, M.P., Choudhary, C., Granzier, H.L., Woulfe, K.C. and McKinsey, T.A.
Journal of Clinical Investigation 132
(10): e148333.
16 May 2022
Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H., Badillo-Lisakowski, V., Britto-Borges, T., Kubli, D.A., Jüttner, R., Parakkat, P., Lopez Carballo, J., Hüttemeister, J., Liss, M., Hansen, A., Dieterich, C., Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13
(622): eabe8952.
December 2021
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118
(23): e2101119118.
8 June 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J.R., Sutanto, H., Pacheu Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuβ, G., Gotthardt, M., Rog-Zielinska, E.A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J.W., Heijman, J., Voigt, N., Cyganek, L., Lenz, C. and Lehnart, S.E.
Circulation Research 128
(6): e102-e120.
19 March 2021
Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F., Fink, C., Hüttemeister, J., Kirchner, M., Radke, M.H., Lopez Carballo, J., Wagner, E., Kohl, T., Lehnart, S.E., Mertins, P. and Gotthardt, M.
Nature Communications 11
(1): 3133.
19 June 2020
Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J., Weithauser, A., Witkowski, M., Rauch, B.H., Savvatis, K., Dörner, A., Tabaraie, T., Kasner, M., Moos, V., Bösel, D., Gotthardt, M., Radke, M.H., Wegner, M., Bobbert, P., Lassner, D., Tschöpe, C., Schutheiss, H.P., Felix, S.B., Landmesser, U. and Rauch, U.
European Heart Journal 40
(40): 3318-3332.
21 October 2019
Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Radke, M.H., Polack, C., Methawasin, M., Fink, C., Granzier, H.L. and Gotthardt, M.
Circulation 139
(15): 1813-1827.
9 April 2019
Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46
(10): 5227-5238.
1 June 2018
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F., Haas, J., Zhu, F., Geier, C., Kayvanpour, E., Liss, M., Lai, A., Frese, K., Pribe-Wolferts, R., Amr, A., Li, D.T., Samani, O.S., Carstensen, A., Bordalo, D.M., Müller, M., Fischer, C., Shao, J., Wang, J., Nie, M., Yuan, L., Haßfeld, S., Schwartz, C., Zhou, M., Zhou, Z., Shu, Y., Wang, M., Huang, K., Zeng, Q., Cheng, L., Fehlmann, T., Ehlermann, P., Keller, A., Dieterich, C., Streckfuß-Bömeke, K., Liao, Y., Gotthardt, M., Katus, H.A. and Meder, B.
European Heart Journal 38
(46): 3449-3460.
7 December 2017
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356
(6335): 307-311.
21 April 2017
Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S., Kohl, T., Williams, G.S.B., Gusev, K., Wagner, E., Rog-Zielinska, E.A., Hebisch, E., Dura, M., Didié, M., Gotthardt, M., Nikolaev, V.O., Hasenfuss, G., Kohl, P., Ward, C.W., Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126
(10): 3999-4015.
3 October 2016
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M., Ware, J.S., Herman, D.S., Schafer, S., Baksi, J., Bick, A.G., Buchan, R.J., Walsh, R., John, S., Wilkinson, S., Mazzarotto, F., Felkin, L.E., Gong, S., MacArthur, J.A.L., Cunningham, F., Flannick, J., Gabriel, S.B., Altshuler, D.M., Macdonald, P.S., Heinig, M., Keogh, A.M., Hayward, C.S., Banner, N.R., Pennell, D.J., O'Regan, D.P., San, T.R., de Marvao, A., Dawes, T.J.W., Gulati, A., Birks, E.J., Yacoub, M.H., Radke, M., Gotthardt, M., Wilson, J.G., O'Donnell, C.J., Prasad, S.K., Barton, P.J.R., Fatkin, D., Hubner, N., Seidman, J.G., Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7
(270): 270ra6.
14 January 2015
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124
(8): 3419-3430.
1 August 2014
Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J., Bezzina, C.R., Freiberg, F., Verkerk, A.O., Adriaens, M.E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T.T., Baczko, I., Dos Remedios, C.G., George, A.L., Bishopric, N.H., Lodder, E.M., de Bakker, J.M.T., Fischer, R., Coronel, R., Wilde, A.A.M., Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63
(6): 549-559.
18 February 2014
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Lincoln, S.E., Parrish, A.M., Dauksaite, V., Vakeel, P., Klaassen, S., Gerull, B., Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R., Perrot, A., Ozcelik, C., Saar, K., Hubner, N. and Gotthardt, M.
Nature Medicine 18
(5): 766-773.
May 2012
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K., Pietas, A., Radke, M.H. and Gotthardt, M.
Journal of Cell Biology 193
(4): 785-798.
16 May 2011
Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y., Chen, C., Lisewski, U., Wrackmeyer, U., Radke, M., Westermann, D., Sauter, M., Tschoepe, C., Poller, W., Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53
(14): 1219-1226.
7 April 2009
The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U., Shi, Y., Wrackmeyer, U., Fischer, R., Chen, C., Schirdewan, A., Juettner, R., Rathjen, F.G., Poller, W., Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205
(10): 2369-2379.
29 September 2008
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10
(11): 1449-1457.
November 2007
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J., Raddatz, K., Molkentin, J.D., Wu, Y., Labeit, S., Granzier, H. and Gotthardt, M.
Circulation 115
(6): 743-751.
13 February 2007
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S., Bergmann, N., Luo, X., Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173
(4): 559-570.
22 May 2006
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13461-13466.
7 September 2005
Gouti, Mina
Canonical and non-canonical integrin-based adhesions dynamically interconvert.
Lukas, F., Matthaeus, C., López-Hernández, T., Lahmann, I., Schultz, N., Lehmann, M., Puchkov, D., Pielage, J., Haucke, V. and Maritzen, T.
Nature Communications 15
(1): 2093.
7 March 2024
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14
(1): 8043.
19 December 2023
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation.
Blassberg, R., Patel, H., Watson, T., Gouti, M., Metzis, V., Delás, M.J. and Briscoe, J.
Nature Cell Biology 24
(5): 633-644.
May 2022
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Nervous system regionalization entails axial allocation before neural differentiation.
Metzis, V., Steinhauser, S., Pakanavicius, E., Gouti, M., Stamataki, D., Ivanovitch, K., Watson, T., Rayon, T., Mousavy Gharavy, S.N., Lovell-Badge, R., Luscombe, N.M. and Briscoe, J.
Cell 175
(4): 1105-1118.
1 November 2018
Großwendt, Stefanie (MDC/BIH)
Extraembryonic gut endoderm cells undergo programmed cell death during development.
Batki, J., Hetzel, S., Schifferl, D., Bolondi, A., Walther, M., Wittler, L., Grosswendt, S., Herrmann, B.G. and Meissner, A.
Nature Cell Biology 26
(6): 868-877.
June 2024
Basal delamination during mouse gastrulation primes pluripotent cells for differentiation.
Sato, N., Rosa, V.S., Makhlouf, A., Kretzmer, H., Sampath Kumar, A., Grosswendt, S., Mattei, A.L., Courbot, O., Wolf, S., Boulanger, J., Langevin, F., Wiacek, M., Karpinski, D., Elosegui-Artola, A., Meissner, A., Zernicka-Goetz, M. and Shahbazi, M.N.
Developmental Cell 59
(10): 1252-1268.
20 May 2024
Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.
Grosswendt, S., Filipchyk, A., Manzano, M., Klironomos, F., Schilling, M., Herzog, M., Gottwein, E. and Rajewsky, N.
Molecular Cell 54
(6): 1042-1054.
19 June 2014
Haas, Simon (MDC/BIMSB/BIH)
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy.
Lutz, R., Grünschläger, F., Simon, M., Awwad, M.H.S., Bauer, M., Yousefian, S., Beumer, N., Jopp-Saile, L., Sedlmeier, A., Solé-Boldo, L., Avanesyan, B., Vonficht, D., Stelmach, P., Steinbuss, G., Boch, T., Steiger, S., Baertsch, M.A., Prokoph, N., Rippe, K., Durie, B.G.M., Wickenhauser, C., Trumpp, A., Müller-Tidow, C., Hübschmann, D., Weinhold, N., Raab, M.S., Brors, B., Goldschmidt, H., Imbusch, C.D., Hundemer, M. and Haas, S.
Nature Communications 15
(1): 10396.
29 November 2024
Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study.
Derigs, P., Schubert, M.L., Dreger, P., Schmitt, A., Yousefian, S., Haas, S., Röthemeier, C., Neuber, B., Hückelhoven-Krauss, A., Brüggemann, M., Bernhard, H., Kobbe, G., Lindemann, A., Rummel, M., Michels, B., Korell, F., Ho, A.D., Müller-Tidow, C. and Schmitt, M.
Leukemia 38
(11): 2419-2428.
November 2024
Cellular atlases are unlocking the mysteries of the human body.
Yanai, I., Haas, S., Lippert, C. and Kretzmer, H.
Nature 635
(8039): 553-555.
November 2024
Aggressive lymphoma after CD19 CAR T-cell therapy.
Kobbe, G., Brüggemann, M., Baermann, B.N., Wiegand, L., Trautmann, H., Yousefian, S., Libertini, S., Menssen, H.D., Maier, H.J., Ulrich, P., Gao, J., Bruch, P.M., Liebers, N., Radujkovic, A., Seifert, M., Schniederjohann, C., Paramasivam, N., Fitzgerald, D., Seidel, M., Esposito, I., Germing, U., Cadeddu, R.P., Nachtkamp, K., Jäger, P., Ulrych, T., Fischer, J.C., Rox, J.M., Giesel, F., Koch, R., Antoch, G., Distler, J.H.W., Meuth, S.G., Jacobsen, M., Hübschmann, D., Lu, J., Iaccarino, I., Haas, S., Damm, F. and Dietrich, S.
New England Journal of Medicine 391
(13): 1217-1226.
3 October 2024
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
The cycling and aging mouse female reproductive tract at single-cell resolution.
Winkler, I., Tolkachov, A., Lammers, F., Lacour, P., Daugelaite, K., Schneider, N., Koch, M.L., Panten, J., Grünschläger, F., Poth, T., Ávila, B.M.d., Schneider, A., Haas, S., Odom, D.T. and Gonçalves, Â.
Cell 187
(4): 981-998.
15 February 2024
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk, M.C., Gleixner, J.G., Heigwer, F., Vonficht, D., Valentini, E., Aydin, Z., Tonin, E., Del Prete, S., Mahara, S., Throm, Y., Hetzer, J., Heide, D., Stegle, O., Odom, D.T., Feldmann, A., Haas, S., Heikenwalder, M. and Boutros, M.
Developmental Cell 58
(24): 2914-2929.
18 December 2023
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Eifert, T., Hsu, C.J., Becker, A.L., Graessle, S., Horne, A., Bemmann, F., Zhang, Q., Heuser, M., Vasioukhin, V., Scholl, S., Hochhaus, A., Siegerist, F., Endlich, N., Bullinger, L., Lane, S.W., Haas, S., Schnoeder, T.M and Heidel, F.H.
Leukemia 37
(10): 2027-2035.
October 2023
Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis.
Solé-Boldo, L. and Haas, S.
Nature Genetics 55
(9): 1430-1431.
September 2023
Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
John, L., Poos, A.M., Brobeil, A., Schinke, C., Huhn, S., Prokoph, N., Lutz, R., Wagner, B., Zangari, M., Tirier, S.M., Mallm, J.P., Schumacher, S., Vonficht, D., Solé-Boldo, L., Quick, S., Steiger, S., Przybilla, M.J., Bauer, K., Baumann, A., Hemmer, S., Rehnitz, C., Lückerath, C., Sachpekidis, C., Mechtersheimer, G., Haberkorn, U., Dimitrakopoulou-Strauss, A., Reichert, P., Barlogie, B., Müller-Tidow, C., Goldschmidt, H., Hillengass, J., Rasche, L., Haas, S.F., van Rhee, F., Rippe, K., Raab, M.S., Sauer, S. and Weinhold, N.
Nature Communications 14
(1): 5011.
17 August 2023
Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.
Schubert, M.L., Schmitt, A., Hückelhoven-Krauss, A., Neuber, B., Kunz, A., Waldhoff, P., Vonficht, D., Yousefian, S., Jopp-Saile, L., Wang, L., Korell, F., Keib, A., Michels, B., Haas, D., Sauer, T., Derigs, P., Kulozik, A., Kunz, J., Pavel, P., Laier, S., Wuchter, P., Schmier, J., Bug, G., Lang, F., Gökbuget, N., Casper, J., Görner, M., Finke, J., Neubauer, A., Ringhoffer, M., Wolleschak, D., Brüggemann, M., Haas, S., Ho, A.D., Müller-Tidow, C., Dreger, P. and Schmitt, M.
Journal of Hematology & Oncology 16
(1): 79.
22 July 2023
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia.
Beneyto-Calabuig, S., Merbach, A.K., Kniffka, J.A., Antes, M., Szu-Tu, C., Rohde, C., Waclawiczek, A., Stelmach, P., Gräßle, S., Pervan, P., Janssen, M., Landry, J.J.M., Benes, V., Jauch, A., Brough, M., Bauer, M., Besenbeck, B., Felden, J., Bäumer, S., Hundemer, M., Sauer, T., Pabst, C., Wickenhauser, C., Angenendt, L., Schliemann, C., Trumpp, A., Haas, S., Scherer, M., Raffel, S., Müller-Tidow, C. and Velten, L.
Cell Stem Cell 30
(5): 706-721.
4 May 2023
Cellular hierarchies predict drug response in acute myeloid leukemia.
Raffel, S., Velten, L. and Haas, S.
Cancer Cell 40
(9): 917-919.
12 September 2022
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska, R., Mikecin, A.M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S.V., Asada, N., Rodriguez-Correa, E., Frauhammer, F., Buettner, F., Ball, M., Knoch, J., Stäble, S., Walter, D., Petri, A., Carreño-Gonzalez, M.J., Wagner, V., Brors, B., Haas, S., Lipka, D.B., Essers, M.A.G., Weru, V., Holland-Letz, T., Mallm, J.P., Rippe, K., Krämer, S., Schlesner, M., McKinney Freeman, S., Florian, M.C., King, K.Y., Frenette, P.S., Rieger, M.A. and Milsom, M.D.
Cell Stem Cell 29
(8): 1273-1284.
4 August 2022
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P., Vonficht, D., Schnell, A., Uckelmann, H.J., Bollhagen, A., Mahmoud, M.A.A., Landua, S.L., van der Salm, E., Trautmann, C., Raffel, S., Grünschläger, F., Lutz, R., Ghosh, M., Renders, S., Correia, N., Donato, E., Dixon, K.O., Hirche, C., Andresen, C., Robens, Cl., Werner, P.S., Boch, T., Eisel, D., Osen, W., Pilz, F., Przybylla, A., Klein, C., Buchholz, F., Milsom, M.D., Essers, M.A.G., Eichmüller, S.B., Hofmann, W.K., Nowak, D., Hübschmann, D., Hundemer, M., Thiede, C., Bullinger, L., Müller-Tidow, C., Armstrong, S.A., Trumpp, A., Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29
(5): 760-775.
5 May 2022
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M., Böger, M., Yousefian, S., Grunert, C., Zhang, L., Hotz, P.W., Gottschlich, A., Köse, H., Isaakidis, K., Vonficht, D., Grünschläger, F., Rohleder, E., Wagner, K., Dönig, J., Igl, V., Brzezicha, B., Baumgartner, F., Habringer, S., Löber, J., Chapuy, B., Weidinger, C., Kobold, S., Haas, S., Busse, A.B., Müller, S., Wirth, M., Schick, M. and Keller, U.
Journal of Clinical Investigation 132
(9): e152383.
2 May 2022
Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells.
Trumpp, A. and Haas, S.
Cell 185
(8): 1266-1270.
14 April 2022
ATACing single cells with phages.
Maschmeyer, P. and Haas, S.
Molecular Cell 82
(2): 234-236.
20 January 2022
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., Boch, T., Jann, J.C., Nowak, D., Hofmann, W.K., Müller-Tidow, C., Hübschmann, D., Alexandrov, T., Benes, V., Trumpp, A., Paulsen, M., Velten, L. and Haas, S.
Nature Immunology 22
(12): 1577-1589.
December 2021
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Young, K., Eudy, E., Bell, R., Loberg, M.A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.D. and Trowbridge, J.J.
Cell Stem Cell 28
(8): 1473-1482.
5 August 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L., Story, B.A., Hernández-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Frömel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Müller-Tidow, C., Trumpp, A., Haas, S. and Steinmetz, L.M.
Nature Communications 12
(1): 1366.
1 March 2021
Haghverdi, Laleh (BIMSB)
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
Hammes-Lewin, Annette
Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383
(6686): 992-998.
1 March 2024
Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R., Fast, E.M., Solaimani, P., Knezevic, K., Eliades, A., Patel, R., Thambyrajah, R., Unnikrishnan, A., Thoms, J., Beck, D., Vink, C.S., Smith, A., Wong, J., Shepherd, M., Kent, D., Roychoudhuri, R., Paul, F., Klippert, J., Hammes, A., Willnow, T., Göttgens, B., Dzierzak, E., Zon, L.I., Lacaud, G., Kouskoff, V. and Pimanda, J.E.
Blood 128
(15): 1928-1939.
13 October 2016
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A., Christa, A., Kur, E., Lioubinski, O., Bachmann, S., Willnow, T.E. and Hammes, A.
Developmental Cell 22
(2): 268-278.
14 February 2012
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A., Monet-Lepretre, M., Gosele, C., Baron-Menguy, C., Hammes, A., Schmidt, S., Lemaire-Carrette, B., Domenga, V., Schedl, A., Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120
(2): 433-445.
1 February 2010
Role of endocytosis in cellular uptake of sex steroids.
Hammes, A., Andreassen, T.K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F.J., Luppa, P.B., Nykjaer, A. and Willnow, T.E.
Cell 122
(5): 751-762.
9 September 2005
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.
Hammes, A., Guo, J.K., Lutsch, G., Leheste, J.R., Landrock, D., Ziegler, U., Gubler, M.C. and Schedl, A.
Cell 106
(3): 319-329.
10 August 2001
Harrington, Kyle
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8
(7): 1252-1266.
July 2023
RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
Bahry, E., Breimann, L., Zouinkhi, M., Epstein, L., Kolyvanov, K., Mamrak, N., King, B., Long, Xi, Harrington, K.I.S., Lionnet, T. and Preibisch, S.
Nature Methods 19
(12): 1563-1567.
December 2022
SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C., Günther, U., Eddison, M., Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18
: 374-377.
April 2021
Hastermann, Maria (ECRC)
Autoantigen-specific CD4(+) T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.S., Dargvainiene, J., Martini, G.R., Stürner, K.H., Schröder, I., Markewitz, R., Hartl, J., Hastermann, M., Duchow, A., Schindler, P., Becker, M., Bautista, C., Gottfreund, J., Walter, J., Polansky, J.K., Yang, M., Naghavian, R., Wendorff, M., Schuster, E.M., Dahl, A., Petzold, A., Reinhardt, S., Franke, A., Wieczorek, M., Henschel, L., Berger, D., Heine, G., Holtsche, M., Häußler, V., Peters, C., Schmidt, E., Fillatreau, S., Busch, D.H., Wandinger, K.P., Schober, K., Martin, R., Paul, F., Leypoldt, F. and Scheffold, A.
Immunity 57
(10): 2416-2432.e8.
8 October 2024
Hedtrich, Sarah (BIH/MDC)
Next generation concepts in dermal delivery, theranostics, and preclinical testing.
Hedtrich, S. and Calderón, M.
Advanced Drug Delivery Reviews
: 115482.
29 November 2024
(In Press)
Modulating the mucosal drug delivery efficiency of polymeric nanogels tuning their redox response and surface charge.
Udabe, J., Muñoz‐Juan, A., Tafech, B., Orellano, M.S., Hedtrich, S., Laromaine, A. and Calderón, M.
Advanced Functional Materials 34
(45): 2407044.
5 November 2024
Exploring mechanisms of lipid nanoparticle-mucus interactions in healthy and cystic fibrosis conditions.
Tafech, B., Rokhforouz, M.R., Leung, J., Sung, M.M., Lin, P.J., Sin, D.D., Lauster, D., Block, S., Quon, B.S., Tam, Y., Cullis, P., Feng, J.J. and Hedtrich, S.
Advanced Healthcare Materials 13
(18): e2304525.
17 July 2024
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps.
Wu, J., Jones, N., Chao, P.H., Chan, V., Hohenwarter, L., Wu, A., Bergamo, M., Rodríguez-Rodríguez, C., Saatchi, K., Liang, A., Häfeli, U.O., Tan, Z., Hedtrich, S., Andrew, L.J. and Li, S.D.
Biomaterials 308
: 122567.
July 2024
Lipid nanoparticle-mediated hit-and-run approaches yield efficient and safe in situ gene editing in human skin.
Bolsoni, J., Liu, D., Mohabatpour, F., Ebner, R., Sadhnani, G., Tafech, B., Leung, J., Shanta, S., An, K., Morin, T., Chen, Y., Arguello, A., Choate, K., Jan, E., Ross, C.J.D., Brambilla, D., Witzigmann, D., Kulkarni, J., Cullis, P.R. and Hedtrich, S.
ACS Nano 17
(21): 22046-22059.
14 November 2023
Heinemann, Udo
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske, Y., Cappel, C., Cremer, N., Hoffmann, P., Koudelka, T., Tholey, A., Heinemann, U., Daumke, O. and Damme, M.
Nucleic Acids Research 52
(1): 370-384.
11 January 2024
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T., Stolzenberg, S., Sticht, J., Wieczorek, M., Roske, Y., Günther, M., Dähn, S., Boesen, B.B., Calvo, M.M., Biese, C., Kuppler, F., Medina-García, Á., Álvaro-Benito, M., Höfer, T., Noé, F. and Freund, C.
Nature Chemical Biology 19
(10): 1196-1204.
October 2023
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A., Roske, Y., Yamada, S., Uehata, T., Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49
(9): 5369-5381.
21 May 2021
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M., Müller, M., Chiha, S., Ren, J., Albat, D., Soicke, A., Dohmen, S., Klein, M., Bruns, J., van Dinther, M., Opitz, R., Lindemann, P., Beerbaum, M., Motzny, K., Roske, Y., Schmieder, P., Volkmer, R., Nazaré, M., Heinemann, U., Oschkinat, H., Ten Dijke, P., Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117
(47): 29684-29690.
24 November 2020
Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S., Gohlke, U., Broeker, N.K., Roske, Y., Heinemann, U., Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140
(33): 10447-10455.
22 August 2018
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q., Roske, Y., Schuetz, A., Walentin, K., Ibraimi, I., Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46
(4): 2082-2095.
28 February 2018
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
Consentius, P., Gohlke, U., Loll, B., Alings, C., Mueller, R., Heinemann, U., Kaupp, M., Wahl, M. and Risse, T.
Journal of the American Chemical Society 138
(39): 12868-12875.
5 October 2016
Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
Kang, Y., Gohlke, U., Engström, O., Hamark, C., Scheidt, T., Kunstmann, S., Heinemann, U., Widmalm, G., Santer, M. and Barbirz, S.
Journal of the American Chemical Society 138
(29): 9109-9118.
27 July 2016
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M. and Heinemann, U.
Nature Communications 5
: 5701.
11 December 2014
Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A., Wagner, S., Ortwein, J., Kim, B.G., Lisurek, M., Beligny, S., Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51
(37): 9441-9447.
10 September 2012
PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactose.
Mueller, J.J., Weiss, M.S. and Heinemann, U.
Acta Crystallographica Section D 67
(Pt 11): 936-944.
November 2011
Crystal structure of nucleotide-free dynamin.
Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noe, F. and Daumke, O.
Nature 477
(7366): 556-560.
29 September 2011
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T. and Jarosch, E.
Molecular Cell 36
(5): 782-793.
11 December 2009
Protein production and purification.
Gräslund, S., Nordlund, P., Weigelt, J., Hallberg, M., Bray, J., Gileadi, O., Knapp, S., Oppermann, U., Arrowsmith, C., Hui, R., Ming, J., dhe-Paganon, S., Park, H.W., Savchenko, A., Yee, A., Edwards, A., Vincentelli, R., Cambillau, C., Kim, R., Kim, S.H., Rao, Z., Shi, Y., Terwilliger, T.C., Kim, C.Y., Hung, L.W., Waldo, G.S., Peleg, Y., Albeck, S., Unger, T., Dym, O., Prilusky, J., Sussman, J.L., Stevens, R.C., Lesley, S.A., Wilson, I.A., Joachimiak, A., Collart, F., Dementieva, I., Donnelly, M.I., Eschenfeldt, W.H., Kim, Y.M., Stols, L., Wu, R., Zhou, M., Burley, S.K., Emtage, J.S., Sauder, J.M., Thompson, D., Bain, K., Luz, J., Gheyi, T., Zhang, F., Atwell, S., Almo, S.C., Bonanno, J.B., Fiser, A., Swaminathan, S., Studier, F.W., Chance, M.R., Sali, A., Acton, T.B., Xiao, R., Zhao, L., Ma, L.C., Hunt, J.F., Tong, L., Cunningham, K., Inouye, M., Anderson, S., Janjua, H., Shastry, R., Ho, C.K., Wang, D., Wang, H., Jiang, M., Montelione, G.T., Stuart, D.I., Owens, R.J., Daenke, S., Schütz, A., Heinemann, U., Yokoyama, S., Büssow, K. and Gunsalus, K.C.
Nature Methods 5
(2): 135-146.
February 2008
Building functional modules from molecular interactions.
Hofmann, K.P., Spahn, C.M.T., Heinrich, R. and Heinemann, U.
Trends in Biochemical Sciences 31
(9): 497-508.
September 2006
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P., Kuemmel, D., Prinz, B., Holz, C., Schultchen, J., Lang, C., Niesen, F.H., Hofmann, K.P., Delbrueck, H., Behlke, J., Mueller, E.C., Jarosch, E., Sommer, T. and Heinemann, U.
EMBO Journal 24
(5): 875-884.
1 January 2005
Facilities and methods for the high-throughput crystal structural analysis of human proteins.
Heinemann, U., Buessow, K., Mueller, U. and Umbach, P.
Accounts of Chemical Research 36
(3): 157-163.
March 2003
LG/LNS domains: multiple functions - one business end?
Rudenko, G., Hohenester, E. and Muller, Y.A.
Trends in Biochemical Sciences 26
(6): 363-368.
1 January 2001
Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Schwartz, T., Behlke, J., Lowenhaupt, K., Heineman, U. and Rich, A.
Nature Structural Biology 8
(9): 761-765.
1 January 2001
Structural genomics in Europe: slow start, strong finish?
Heinemann, U.
Nature Structural Biology 7
(Suppl): 940-942.
1 November 2000
Two exposed amino acid residues confer thermostability on a cold shock protein.
Perl, D., Mueller, U., Heinemann, U. and Schmid, F.X.
Nature Structural Biology 7
: 380-383.
1 May 2000
Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
Grishkovskaya, I., Avvakumov, G.V., Sklenar, G., Dales, D., Hammond, G.L. and Muller, Y.A.
EMBO Journal 19
(4): 504-512.
15 February 2000
The Opitz syndrome gene product, MID1, associates with microtubules.
Schweiger, S., Foerster, J., Lehman, T., Suckow, V., Muller, Y.A., Walter, G., Davies, T., Porter, H., van Bokhoven, H., Lunt, P.W., Traub, P. and Ropers, H.H.
Proceedings of the National Academy of Sciences of the United States of America 96
: 2794-2799.
16 March 1999
Circular permutations of protein sequence: not so rare?
Heinemann, U. and Hahn, M.
Trends in Biochemical Sciences 20
(9): 349-350.
1 January 1995
Crystal structure of CspA, the major cold shock protein of Escherichia coli.
Schindelin, H., Jiang, W., Inouye, M. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91
(11): 5119-5123.
24 May 1994
Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis.
Hahn, M., Piotukh, K., Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91
: 10417-10421.
1 January 1994
Henssen, Anton (MDC/ECRC)
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung, K.L., Jones, M.G., Wong, I.T.L., Curtis, E.J., Lange, J.T., He, B.J., Luebeck, J., Schmargon, R., Scanu, E., Brückner, L., Yan, X., Li, R., Gnanasekar, A., Chamorro González, R., Belk, J.A., Liu, Z., Melillo, B., Bafna, V., Dörr, J.R., Werner, B., Huang, W., Cravatt, B.F., Henssen, A.G., Mischel, P.S and Chang, H.Y.
Nature 635
(8037): 201-209.
7 November 2024
Genetic determinants of micronucleus formation in vivo.
Adams, D.J., Barlas, B., McIntyre, R.E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J.R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N.A., Harle, V., Olvera-León, R., Robles-Espinoza, C.D., Speak, A.O., Geisler, N., Weninger, W.J., Geyer, S.H., Hewinson, J., Karp, N.A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M.S., Rowland, B.D., Lelliott, C.J., Del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A.G., Rooimans, M.A., de Lange, J., Mohun, T.J., Arends, M.J., Kentistou, K.A., Coelho, P.A., Zhao, Y., Zecchini, H., Perry, J.R.B., Jackson, S.P. and Balmus, G.
Nature 627
(8002): 130-136.
7 March 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
Nurminen, A., Jaatinen, S., Taavitsainen, S., Högnäs, G., Lesluyes, T., Ansari-Pour, N., Tolonen, T., Haase, K., Koskenalho, A., Kankainen, M., Jasu, J., Rauhala, H., Kesäniemi, J., Nikupaavola, T., Kujala, P., Rinta-Kiikka, I., Riikonen, J., Kaipia, A., Murtola, T., Tammela, T.L., Visakorpi, T., Nykter, M., Wedge, D.C., Van Loo, P. and Bova, G.S.
Genome Medicine 15
(1): 82.
12 October 2023
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E., Planas-Fèlix, M., Burkert, M., Puiggròs, M., Toedling, J., Thiessen, N., Blanc, E., Szymansky, A., Hertwig, F., Ishaque, N., Beule, D., Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F., Haase, K., Schulte, J.H. and Henssen, A.G.
Cell Genomics 3
(10): 100402.
11 October 2023
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14
(1): 3936.
4 July 2023
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55
(5): 880-890.
May 2023
Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq.
Chamorro González, R. and Henssen, A.G.
Nature Genetics 55
(5): 740-741.
May 2023
Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H., Schöberl, F., Giurgiu, M., Leal Silva, R.M., Scholz, V., Scharf, F., Wendlandt, M., Kleinle, S., Deschauer, M., Nübling, G., Heide, W., Babacan, S.S., Schneider, C., Neuhann, T., Hahn, K., Schoser, B., Holinski-Feder, E., Wolf, D.A. and Abicht, A.
Brain 146
(5): 1831-1843.
May 2023
Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch, T., Snajder, R., Leger, A., Simovic, M., Giurgiu, M., Villacorta, L., Henssen, A.G., Fröhling, S., Stegle, O., Birney, E., Bonder, M.J., Ernst, A. and Korbel, J.O.
Cell Genomics 3
(4): 100281.
12 April 2023
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
Danielli, S.G., Porpiglia, E., De Micheli, A.J., Navarro, N., Zellinger, M.J., Bechtold, I., Kisele, S., Volken, L., Marques, J.G., Kasper, S., Bode, P.K., Henssen, A.G., Gürgen, D., Delattre, O., Surdez, D., Roma, J., Bühlmann, P., Blau, H.M., Wachtel, M. and Schäfer, B.W.
Science Advances 9
(6): eade9238.
10 February 2023
Extrachromosomal DNA amplifications in cancer.
Yi, E., Chamorro González, R., Henssen, A.G. and Verhaak, R.G.W.
Nature Reviews Genetics 23
(12): 760-771.
December 2022
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L., Luebeck, J., Dehkordi, S.R., Colón, C.I., Li, R., Wong, I.T.L., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E., Moriceau, G., Zhang, X., Bailey, C., Houlahan, K.E., Yang, W., González, R.C., Swanton, C., Curtis, C., Jamal-Hanjani, M., Henssen, A.G., Law, J.A., Greenleaf, W.J., Lo, R.S., Mischel, P.S., Bafna, V. and Chang, H.Y.
Nature Genetics 54
(11): 1746–1754.
November 2022
The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T., Rose, J.C., Chen, C.Y., Pichugin, Y., Xie, L., Tang, J., Hung, K.L., Yost, K.E., Shi, Q., Erb, M.L., Rajkumar, U., Wu, S., Taschner-Mandl, S., Bernkopf, M., Swanton, C., Liu, Z., Huang, W., Chang, H.Y., Bafna, V., Henssen, A.G., Werner, B. and Mischel, P.S.
Nature Genetics 54
(10): 1527-1533.
October 2022
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13
(1): 4297.
25 July 2022
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M., Tucker, E., Dorel, M., Winkler, A., McGearey, A., Rodriguez-Fos, E., da Costa, B.M., Barker, K., Fyle, E., Calton, E., Eising, S., Ober, K., Hughes, D., Koutroumanidou, E., Carter, P., Stankunaite, R., Proszek, P., Jain, N., Rosswog, C., Dorado-Garcia, H., Molenaar, J.J., Hubank, M., Barone, G., Anderson, J., Lang, P., Deubzer, H.E., Künkele, A., Fischer, M., Eggert, A., Kloft, C., Henssen, A.G., Boettcher, M., Hertwig, F., Blüthgen, N., Chesler, L. and Schulte, J.H.
Molecular Cancer 21
(1): 126.
10 June 2022
Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G.
Cancer Discovery 12
(2): 293-295.
9 February 2022
The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E., Brückner, L. and Henssen, A.G.
Nature Genetics 54
(2): 107-114.
February 2022
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J., Huska, M., Cwikla, M.C., Kruetzfeldt, L.M., Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y., Burkert, M., Guergen, D., Szymansky, A., Astrahantseff, K., Kuenkele, A., Haase, K., Fischer, M., Deubzer, H.E., Hertwig, F., Hundsdoerfer, P., Henssen, A.G., Schwarz, R.F., Schulte, J.H. and Eggert, A.
Nature Communications 12
(1): 6804.
23 November 2021
Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O., Nehls, N., Prexler, C., von Heyking, K., Groll, T., Pardon, K., Garcia, H.D., Hensel, T., Gürgen, D., Henssen, A.G., Eggert, A., Steiger, K., Burdach, S. and Richter, G.H.S.
Journal of Experimental & Clinical Cancer Research 40
(1): 322.
15 October 2021
Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K., Kaljunen, H., Taavitsainen, S., Kaarijärvi, R., Järvelä, E., Rodriguez Martin, B., Haase, K., Woodcock, D.J., Tubio, J., Wedge, D.C., Nykter, M. and Bova, G.S.
Cancer Research 81
(19): 4901-4909.
October 2021
Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I., Poon, E., Henssen, A.G., Dorado Garcia, H., Gatti, M., Giansanti, C., Jamin, Y., Ade, C.P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G. and Eilers, M.
Nature Cancer 2
(3): 312-326.
March 2021
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
Heuser, Arnd
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C., Thery, F., Wirth, E.K., Ochs, S., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A.
Cardiovascular Research 120
(6): 644-657.
6 April 2024
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D.A., Blockx, I., Bortel, A., Broadwater, M., Cardoso, B.M., Célestine, M., Chavez-Negrete, J.E., Choi, S., Christiaen, E., Clavijo, P., Colon-Perez, L., Cramer, S., Daniele, T., Dempsey, E., Diao, Y., Doelemeyer, A., Dopfel, D., Dvořáková, L., Falfán-Melgoza, C., Fernandes, F.F., Fowler, C.F., Fuentes-Ibañez, A., Garin, C.M., Gelderman, E., Golden, C.E.M., Guo, C.C G., Henckens, M.J.A.G., Hennessy, L.A., Herman, P., Hofwijks, N., Horien, C., Ionescu, T.M., Jones, J., Kaesser, J., Kim, E., Lambers, H., Lazari, A., Lee, S.H., Lillywhite, A., Liu, Y., Liu, Y.Y., López-Castro, A., López-Gil, X., Ma, Z., MacNicol, E., Madularu, D., Mandino, F., Marciano, S., McAuslan, M.J., McCunn, P., McIntosh, A., Meng, X., Meyer-Baese, L., Missault, S., Moro, F., Naessens, D.M.P., Nava-Gomez, L.J., Nonaka, H., Ortiz, J.J., Paasonen, J., Peeters, L.M., Pereira, M., Perez, P.D., Pompilus, M., Prior, M., Rakhmatullin, R., Reimann, H.M., Reinwald, J., Del Rio, R.T., Rivera-Olvera, A., Ruiz-Pérez, D., Russo, G., Rutten, T.J., Ryoke, R., Sack, M., Salvan, P., Sanganahalli, B.G., Schroeter, A., Seewoo, B.J., Selingue, E., Seuwen, A., Shi, B., Sirmpilatze, N., Smith, J.A.B., Smith, C., Sobczak, F., Stenroos, P.J., Straathof, M., Strobelt, S., Sumiyoshi, A., Takahashi, K., Torres-García, M.E, Tudela, R., van den Berg, M., van der Marel, K., van Hout, A.T.B., Vertullo, R., Vidal, B., Vrooman, R.M., Wang, V.X., Wank, I., Watson, D.J.G., Yin, T., Zhang, Y., Zurbruegg, S., Achard, S., Alcauter, S., Auer, D.P., Barbier, E.L., Baudewig, J., Beckmann, C.F., Beckmann, N., Becq, G.J.P.C., Blezer, E.L.A., Bolbos, R., Boretius, S., Bouvard, S., Budinger, E., Buxbaum, J.D., Cash, D., Chapman, V., Chuang, K.H., Ciobanu, L., Coolen, B.F., Dalley, J.W., Dhenain, M., Dijkhuizen, R.M., Esteban, O., Faber, C., Febo, M., Feindel, K.W., Forloni, G., Fouquet, J., Garza-Villarreal, E.A., Gass, N., Glennon, J.C., Gozzi, A., Gröhn, O., Harkin, A., Heerschap, A., Helluy, X., Herfert, K., Heuser, A., Homberg, J.R., Houwing, D.J., Hyder, F., Ielacqua, G.D., Jelescu, I.O., Johansen-Berg, H., Kaneko, G., Kawashima, R., Keilholz, S.D., Keliris, G.A., Kelly, C., Kerskens, C., Khokhar, J.Y., Kind, P.C., Langlois, J.B., Lerch, J.P., López-Hidalgo, M.A, Manahan-Vaughan, D., Marchand, F., Mars, R.B., Marsella, G., Micotti, E., Muñoz-Moreno, E., Near, J., Niendorf, T., Otte, W.M., Pais-Roldán, P., Pan, W.J., Prado-Alcalá, R.A., Quirarte, G.L., Rodger, J., Rosenow, T., Sampaio-Baptista, C., Sartorius, A., Sawiak, S.J., Scheenen, T.W.J., Shemesh, N., Shih, Y.Y.I., Shmuel, A., Soria, G., Stoop, R., Thompson, G.J., Till, S.M., Todd, N., Van Der Linden, A., van der Toorn, A., van Tilborg, G.A.F, Vanhove, C., Veltien, A., Verhoye, M., Wachsmuth, L., Weber-Fahr, W., Wenk, P., Yu, X., Zerbi, V., Zhang, N., Zhang, B.B., Zimmer, L., Devenyi, G.A., Chakravarty, M.M. and Hess, A.
Nature Neuroscience 26
(4): 673-681.
April 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran, D., Kochlamazashvili, G., Pampaloni, N. P., Sposini, S., Shergill, J.K., Lehmann, M., Pashkova, N., Schmidt, C., Löwe, D., Napieczynska, H., Heuser, A., Plested, A.J.R., Perrais, D., Piper, R.C., Haucke, V. and Maritzen, T.
Science Advances 8
(21): eabl5032.
27 May 2022
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
(6): 1653-1668.
December 2021
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.
Goetzke, C.C., Althof, N., Neumaier, H.L., Heuser, A., Kaya, Z., Kespohl, M., Klingel, K. and Beling, A.
Basic Research in Cardiology 116
(1): 7.
1 February 2021
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M., Fischer, A., Goetzke, C.C., Neumaier, H.L., Sauter, M., Kespohl, M., Müller, A.M., Meckes, C., Salbach, C., Schenk, M., Heuser, A., Landmesser, U., Weiner, J., Meder, B., Lehmann, L., Kratzer, A., Klingel, K., Katus, H.A., Kaya, Z. and Beling, A.
Circulation 141
(23): 1885-1902.
9 June 2020
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N., Foster, D.J., Cunningham, M.W., Bercher, J., Nguyen, T., Shulga-Morskaya, S., Milstein, S., Shaikh, S., Rollins, J., Golic, M., Herse, F., Kräker, K., Bendix, I., Serdar, M., Napieczynska, H., Heuser, A., Gellhaus, A., Thiele, K., Wallukat, G., Müller, D.N., LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130
(6): 2928-2942.
1 June 2020
Statins reverse postpartum cardiovascular dysfunction in a rat model of preeclampsia.
Kräker, K., O'Driscoll, J.M., Schütte, T., Herse, F., Patey, O., Golic, M., Geisberger, S., Verlohren, S., Birukov, A., Heuser, A., Mueller, D.N., Thilaganathan, B., Dechend, R. and Haase, N.
Hypertension 75
(1): 202-210.
January 2020
The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
Althof, N., Goetzke, C.C., Kespohl, M., Voss, K., Heuser, A., Pinkert, S., Kaya, Z., Klingel, K. and Beling, A.
EMBO Molecular Medicine 10
(2): 200-218.
1 February 2018
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L., Haase, N., Golic, M., Rugor, J., Solano, M.E., Arck, P.C., Gauster, M., Huppertz, B., Emontzpohl, C., Stoppe, C., Bernhagen, J., Leng, L., Bucala, R., Schulz, H., Heuser, A., Weedon-Fekjær, S., Johnsen, G.M., Peetz, D., Luft, F.C., Staff, A.C., Müller, D.N., Dechend, R. and Herse, F.
Circulation Research 119
(1): 55-68.
24 June 2016
TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure.
An, J., Harms, C., Lättig-Tünnemann, G., Sellge, G., Mandic, A.D., Malato, Y., Heuser, A., Endres, M., Trautwein, C. and Donath, S.
Hepatology 56
(2): 715-726.
August 2012
Mutations in sarcomere protein genes in left ventricular noncompaction.
Klaassen, S., Probst, S., Oechslin, E., Gerull, B., Krings, G., Schuler, P., Greutmann, M., Huerlimann, D., Yegitbasi, M., Pons, L., Gramlich, M., Drenckhahn, J.D., Heuser, A., Berger, F., Jenni, R. and Thierfelder, L.
Circulation 117
(22): 2893-2901.
3 June 2008
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J., Fischer, J., Paskas, S., Heinig, M., Schulz, H., Goesele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., Gross, V., Hummel, O., Maatz, H., Patone, G., Saar, K., Vingron, M., Weldon, S.M., Lindpaintner, K., Hammock, B.D., Rohde, K., Dietz, R., Cook, S.A., Schunck, W.H., Luft, F.C. and Huebner, N.
Nature Genetics 40
(5): 529-537.
May 2008
Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.
Heuser, A., Plovie, E.R., Ellinor, P.T., Grossmann, K.S., Shin, J.T., Wichter, T., Basson, C.T., Lerman, B.B., Sasse-Klaassen, S., Thierfelder, L., MacRae, C.A. and Gerull, B.
American Journal of Human Genetics 79
(6): 1081-1088.
December 2006
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S., Probst, S., Gerull, B., Oechslin, E., Nuernberg, P., Heuser, A., Jenni, R., Hennies, H.C. and Thierfelder, L.
Circulation 109
(22): 2720-2723.
8 June 2004
Hirsch, Christian
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T. and Jarosch, E.
Molecular Cell 36
(5): 782-793.
11 December 2009
The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C., Gauss, R., Horn, S.C., Neuber, O. and Sommer, T.
Nature 458
(7237): 453-460.
26 March 2009
Coping with stress: cellular relaxation techniques.
Hirsch, C., Gauss, R. and Sommer, T.
Trends in Cell Biology 16
(12): 657-663.
December 2006
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
Gauss, R., Jarosch, E., Sommer, T. and Hirsch, C.
Nature Cell Biology 8
(8): 849-854.
August 2006
ERAD: the long road to destruction.
Meusser, B., Hirsch, C., Jarosch, E. and Sommer, T.
Nature Cell Biology 7
(8): 766-772.
August 2005
San1p, checking up on nuclear proteins.
Sommer, T. and Hirsch, C.
Cell 120
(6): 734-736.
1 January 2005
Hoepken, Uta
CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15
: 1383136.
24 June 2024
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83
(4): 499-507.
12 March 2024
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C., Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S., Tajbakhsh, S., Höpken, U.E. and Stricker, S.
Immunity 56
(6): 1204-1219.
13 June 2023
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13
(1): 7341.
29 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A., Bunse, M., Joedicke, J.J., Blanc, E., Gudipati, V., Moles, M.W., Shiku, H., Beule, D., Huppa, J.B., Höpken, U.E. and Rehm, A.
Molecular Therapy 30
(11): 3358-3378.
2 November 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
(10): msac175.
October 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12
(1): 240.
11 January 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80
(6): 1316-1329.
March 2020
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T., Zhou, X., Kosla, J., Adili, A., Garcia Beccaria, M., Kotsiliti, E., Pfister, D., Johlke, A.L., Sinha, A., Sankowski, R., Schick, M., Lewis, R., Dokalis, N., Seubert, B., Höchst, B., Inverso, D., Heide, D., Zhang, W., Weihrich, P., Manske, K., Wohlleber, D., Anton, M., Hoellein, A., Seleznik, G., Bremer, J., Bleul, S., Augustin, H.G., Scherer, F., Koedel, U., Weber, A., Protzer, U., Förster, R., Wirth, T., Aguzzi, A., Meissner, F., Prinz, M., Baumann, B., Höpken, U.E., Knolle, P.A., von Baumgarten, L., Keller, U. and Heikenwalder, M.
Cancer Cell 36
(3): 250-267.
16 September 2019
Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5
(6): 351-364.
June 2019
Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E.
Cancer Discovery 7
(1): 14-16.
January 2017
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Höpken, U.E.
Blood 124
(19): 2897-2898.
6 November 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37
(5): 854-866.
16 November 2012
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10
(11): 1193-1199.
November 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109
(3): 886-895.
1 February 2007
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W.
Journal of Experimental Medicine 201
(9): 1447-1457.
2 May 2005
All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E. and Lipp, M.
Immunity 20
(3): 244-246.
March 2004
Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A., Sebastiani, S., Höpken, U.E., Uguccioni, M., Lipp, M., Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198
(4): 615-621.
18 August 2003
Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E., Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Immunity 16
(2): 205-218.
1 January 2002
Huebner, Norbert
PITX2 deficiency leads to atrial mitochondrial dysfunction.
Reyat, J.S., Sommerfeld, L.C., O'Reilly, M., Cardoso, V.R., Thiemann, E., Khan, A.O., O'Shea, C., Harder, S., Müller, C., Barlow, J., Stapley, R.J., Chua, W., Kabir, S.N., Grech, O., Hummel, O., Hübner, N., Kääb, S., Mont, Ll., Hatem, S.N., Winters, J., Zeemering, S., Morgan, N.V., Rayes, J., Gehmlich, K., Stoll, M., Brand, T., Schweizer, M., Piasecki, A., Schotten, U., Gkoutos, G.V., Lorenz, K., Cuello, F., Kirchhof, P. and Fabritz, L.
Cardiovascular Research 120
(15): 1907-1923.
November 2024
Amplification of autoimmune organ damage by NKp46-activated ILC1.
Biniaris-Georgallis, S.I., Aschman, T., Stergioula, K., Schreiber, F., Jafari, V., Taranko, A., Karmalkar, T., Kasapi, A., Lenac Rovis, T., Jelencic, V., Bejarano, D.A., Fabry, L., Papacharalampous, M., Mattiola, I., Molgora, M., Hou, J., Hublitz, K.W., Heinrich, F., Guerra, G.M., Durek, P., Patone, G., Lindberg, E.L.H., Maatz, H., Hölsken, O., Krönke, G., Mortha, A., Voll, R.E., Clarke, A.J., Hauser, A.E., Colonna, M., Thurley, K., Schlitzer, A., Schneider, C., Stamatiades, E.G., Mashreghi, M.F., Jonjic, S., Hübner, N., Diefenbach, A., Kanda, M. and Triantafyllopoulou, A.
Nature 634
(8035): 952-960.
24 October 2024
Interleukin 11 therapy causes acute left ventricular dysfunction.
Sweeney, M., O’Fee, K., Villanueva-Hayes, C., Rahman, E., Lee, M., Tam, C.N., Pascual-Navarro, E., Maatz, H., Lindberg, E.L., Vanezis, K., Ramachandra, C.J., Andrew, Iv., Jennings, E.R., Lim, W.W., Widjaja, A.A., Carling, D., Hausenloy, D.J., Hubner, N., Barton, P.J.R. and Cook, S.A.
Cardiovascular Research
: cvae224.
9 October 2024
(In Press)
Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135
(6): 671-684.
30 August 2024
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Widjaja, A.A., Lim, W.W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C.M., Goh, J.W.T., Lim, R., Singh, B.K., Tan, J., Pua, C.J., Lim, S.Y., Adami, E., Schafer, S., George, B.L., Sweeney, M., Xie, C., Tripathi, M., Sims, N.A., Hübner, N., Petretto, E., Withers, D.J., Ho, L., Gil, J., Carling, D. and Cook, S.A.
Nature 632
(8023): 157-165.
1 August 2024
Intergenic risk variant rs56258221 skews the fate of naive CD4(+) T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.
Poch, T., Bahn, J., Casar, C., Krause, J., Evangelakos, I., Gilladi, H., Kunzmann, L.K., Laschtowitz, A., Iuso, N., Schäfer, A.M., Liebig, L.A., Steinmann, S., Sebode, M., Folseraas, T., Engesæter, L.K., Karlsen, T.H., Franke, A., Hubner, N., Schlein, C., Galun, E., Huber, S., Lohse, A.W., Gagliani, N., Schwinge, D. and Schramm, C.
Cell Reports Medicine 5
(7): 101620.
16 July 2024
Microproteins encoded by noncanonical ORFs are a major source of tumor-specific antigens in a liver cancer patient meta-cohort.
Camarena, M.E., Theunissen, P., Ruiz, M., Ruiz-Orera, J., Calvo-Serra, B., Castelo, R., Castro, C., Sarobe, P., Fortes, P., Perera-Bel, J. and Albà, M.M.
Science Advances 10
(28): eadn3628.
July 2024
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I.V., Oelen, R., Groot, H.E., Benjamins, J.W., Brambs, S., Kaiser, R., Gottschlich, A., Hoffmann, G.V., Eivers, L., Martinez-Navarro, A., Bruns, N., Stiller, S., Akgöl, S., Yue, K., Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O., Kobold, S., Petzold, T., Zimmer, R., Enard, W., Saar, K., Mertins, P., Huebner, N., van der Harst, P., Franke, L.H., van der Wijst, M.G.P., Massberg, S., Heinig, M., Nicolai, L. and Stark, K.
Nature Medicine 30
(6): 1696-1710.
June 2024
Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10
(12): eadl1710.
22 March 2024
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Hofman, D.A., Ruiz-Orera, J., Yannuzzi, I., Murugesan, R., Brown, A., Clauser, K.R., Condurat, A.L., van Dinter, J.T., Engels, S.A.G., Goodale, A., van der Lugt, J., Abid, T., Wang, L., Zhou, K.N., Vogelzang, J., Ligon, K.L., Phoenix, T.N., Roth, J.A., Root, D.E, Hubner, N., Golub, T.R., Bandopadhayay, P., van Heesch, S. and Prensner, J.R.
Molecular Cell 84
(2): 261-276.
18 January 2024
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M.K., Shringarpure, S.S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B.M., Thomas, L.F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J.V.T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A., Jeong, A., Fawcett, K.A., Baurecht, H., Rodriguez, E., Alves, A.C., Kumar, A., Sleiman, P.M., Chang, X., Medina-Gomez, C., Hu, C., Xu, C.J., Qi, C., El-Heis, S., Titcombe, P., Antoun, E., Fadista, J., Wang, C.A., Thiering, E., Wu, B., Kress, S., Kothalawala, D.M., Kadalayil, L., Duan, J., Zhang, H., Hadebe, S., Hoffmann, T., Jorgenson, E., Choquet, H., Risch, N., Njølstad, P., Andreassen, O.A., Johansson, S., Almqvist, C., Gong, T., Ullemar, V., Karlsson, R., Magnusson, P.K.E., Szwajda, A., Burchard, E.G., Thyssen, J.P., Hansen, T., Kårhus, L.L., Dantoft, T.M., Jeanrenaud, A.C.S.N., Ghauri, A., Arnold, A., Homuth, G., Lau, S., Nöthen, M.M., Hübner, N., Imboden, M., Visconti, A., Falchi, M., Bataille, V., Hysi, P., Ballardini, N., Boomsma, D.I., Hottenga, J.J., Müller-Nurasyid, M., Ahluwalia, T.S., Stokholm, J., Chawes, B., Schoos, A.M.M., Esplugues, A., Bustamante, M., Raby, B., Arshad, S., German, C., Esko, T., Milani, L.A., Metspalu, A., Terao, C., Abuabara, K., Løset, M., Hveem, K., Jacobsson, B., Pino-Yanes, M., Strachan, D.P., Grarup, N., Linneberg, A., Lee, Y., Probst-Hensch, N., Weidinger, S., Jarvelin, M.R., Melén, E., Hakonarson, H., Irvine, A.D., Jarvis, D., Nijsten, T., Duijts, L., Vonk, J.M., Koppelmann, G.H., Godfrey, K.M., Barton, S.J., Feenstra, B., Pennell, C.E., Sly, P.D., Holt, P.G., Williams, L.K., Bisgaard, H., Bønnelykke, K., Curtin, J., Simpson, A., Murray, C., Schikowski, T., Bunyavanich, S., Weiss, S.T., Holloway, J.W., Min, J.L., Brown, S.J., Standl, M. and Paternoster, L.
Nature Communications 14
(1): 6172.
4 October 2023
Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.
Cui, L., Yang, B., Xiao, S., Gao, J., Baud, A., Graham, D., McBride, M., Dominiczak, A., Schafer, S., Aumatell, R.L., Mont, C., Teruel, A.F., Hübner, N., Flint, J., Mott, R. and Huang, L.
Genome Biology 24
(1): 215.
29 September 2023
Spatially resolved multiomics of human cardiac niches.
Kanemaru, K., Cranley, J., Muraro, D., Miranda, A.M.A., Ho, S.Y., Wilbrey-Clark, A., Patrick Pett, J., Polanski, K., Richardson, L., Litvinukova, M., Kumasaka, R., Qin, Y., Jablonska, Z., Semprich, C.I., Mach, L., Dabrowska, M., Richoz, R., Bolt, L., Mamanova, L., Kapuge, R., Barnett, S.N., Perera, S., Talavera-López, C., Mulas, I., Mahbubani, K.T., Tuck, Liz, Wang, Lu, Huang, M.M., Prete, M., Pritchard, S., Dark, J., Saeb-Parsy, K., Patel, M., Clatworthy, M.R., Hübner, N., Chowdhury, R.A., Noseda, M. and Teichmann, S.A.
Nature 619
: 801-810.
27 July 2023
Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
Milenkovic, I., Santos Vieira, H.G., Lucas, M.C., Ruiz-Orera, J., Patone, G., Kesteven, S., Wu, J., Feneley, M., Espadas, G., Sabidó, E., Hübner, N., van Heesch, S., Völkers, M. and Novoa, E.M.
Nucleic Acids Research 51
(11): 5301-5324.
23 June 2023
Evolution and implications of de novo genes in humans.
Broeils, L.A., Ruiz-Orera, J., Snel, B., Hubner, N. and van Heesch, S.
Nature Ecology & Evolution 7
(6): 804-815.
June 2023
Single-cell transcriptomics for the assessment of cardiac disease.
Miranda, A.M.A., Janbandhu, V., Maatz, H., Kanemaru, K., Cranley, J., Teichmann, S.A., Huebner, N., Schneider, M.D., Harvey, R.P. and Noseda, M.
Nature Reviews Cardiology 20
(5): 289-308.
May 2023
Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Mueller-Calleja, N., Grunz, K., Nguyen, T.S., Posma, J., Pedrosa, D., Meineck, M., Hollerbach, A., Braun, J., Muth, S., Schild, H., Saar, K., Hübner, N., Krishnaswamy, S., Royce, J., Teyton, L., Lemmermann, N.A., Weinmann-Menke, J., Lackner, K.J. and Ruf, W.
Blood 143
(12): 1167-1180.
21 March 2023
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83
(6): 994-1011.e18.
16 March 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Widjaja, A.A., Viswanathan, S., Shekeran, S.G., Adami, E., Lim, W.W., Chothani, S., Tan, J., Goh, J.W.T., Chen, H.M., Lim, S.Y., Boustany-Kari, C.M., Hawkins, J., Petretto, E., Hübner, N., Schafer, S., Coffman, T.M. and Cook, S.A.
Nature Communications 13
(1): 7497.
5 December 2022
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.
Boix, O., Martinez, M., Vidal, S., Giménez-Alejandre, M., Palenzuela, L., Lorenzo-Sanz, L., Quevedo, L., Moscoso, O., Ruiz-Orera, J., Ximénez-Embún, P., Ciriaco, N., Nuciforo, P., Stephan-Otto Attolini, C., Albà, M.M., Muñoz, J., Tian, T.V., Varela, I., Vivancos, A., Ramón Y Cajal, S., Muñoz, P., Rivas, C. and Abad, M.
Nature Communications 13
(1): 6840.
11 November 2022
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana, S., Kretschmer, S., Hunger, S., Yan, X., Kuster, D., Traikov, S., Zillinger, T., Gentzel, M., Elangovan, S., Dasgupta, P., Chappidi, N., Lucas, N., Maser, K.I., Maatz, H., Rapp, A., Marchand, V., Chang, Y.T., Motorin, Y., Hubner, N., Hartmann, G., Hyman, A.A., Alberti, S. and Lee-Kirsch, M.A.
Molecular Cell 82
(19): 3712-3728.e10.
6 October 2022
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D., Lindberg, E.L., Maatz, H., Miranda, A.M.A., Viveiros, A., Shvetsov, N., Gärtner, A., Nadelmann, E.R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D.M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J.M., Barnett, S.N., Brown, K., Buchan, R.J., Chowdhury, R.A., Constantinou, C., Cranley, J., Felkin, L.E., Fox, H., Ghauri, A., Gummert, J., Kanda, M., Li, R., Mach, L., McDonough, B., Samari, S., Shahriaran, F., Yapp, C., Stanasiuk, C., Theotokis, P.I., Theis, F.J., van den Bogaerdt, A., Wakimoto, H., Ware, J.S., Worth, C.L., Barton, P.J.R., Lee, Y.A., Teichmann, S.A., Milting, H., Noseda, M., Oudit, G.Y., Heinig, M., Seidman, J.G., Hubner, N. and Seidman, C.E.
Science 377
(6606): eabo1984.
5 August 2022
A high-resolution map of human RNA translation.
Chothani, S.P., Adami, E., Widjaja, A.A., Langley, S.R., Viswanathan, S., Pua, C.J., Zhihao, N.T., Harmston, N., D'Agostino, G., Whiffin, N., Mao, W., Ouyang, J.F., Lim, W.W., Lim, S., Lee, C.Q.E., Grubman, A., Chen, J., Kovalik, J.P., Tryggvason, K., Polo, J.M., Ho, L., Cook, S.A., Rackham, O.J.L. and Schafer, S.
Molecular Cell 82
(15): 2885-2899.e8.
4 August 2022
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja, A., Wakimoto, H., DeLaughter, D.M., Reichart, D., Gorham, J., Conner, D.A., Lun, M., Probst, C.K., Sakai, N., Knipe, R.S., Montesi, S.B., Shea, B., Adam, L.P., Leinwand, L.A., Wan, W., Choi, E.S., Lindberg, E.L., Patone, G., Noseda, M., Hübner, N., Seidman, C.E., Tager, A.M., Seidman, J.G. and Ho, C.Y.
Proceedings of the National Academy of Sciences of the United States of America 119
(28): e2204174119.
12 July 2022
Standardized annotation of translated open reading frames.
Mudge, J.M., Ruiz-Orera, J., Prensner, J.R., Brunet, M.A., Calvet, F., Jungreis, I., Gonzalez, Jo.M., Magrane, M., Martinez, T.F., Schulz, J.F., Yang, Y.T., Albà, M.M., Aspden, J.L., Baranov, P.V., Bazzini, A.A., Bruford, E., Martin, M.J., Calviello, L., Carvunis, A.R., Chen, J., Couso, J.P., Deutsch, E.W., Flicek, P., Frankish, A., Gerstein, M., Hubner, N., Ingolia, N.T., Kellis, M., Menschaert, G., Moritz, R.L., Ohler, U., Roucou, X., Saghatelian, A., Weissman, J.S. and van Heesch, S.
Nature Biotechnology 40
(7): 994–999.
July 2022
A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome.
Widjaja, A.A., Shekeran, S., Adami, E., Goh, J., Tan, J., Viswanathan, S., Lim, S.Y., Tan, P.H., Hübner, N., Coffman, T. and Cook, S.
Journal of the American Society of Nephrology 33
(4): 718-730.
April 2022
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L.E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J.C., Scherer, C., Rubio-Acero, R., Eser, T., Deák, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K., Tomas, L., Schulz, C., Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M., Iannacone, M., Zimmer, R., Mertins, P., Hubner, N., Hoelscher, M., Massberg, S., Stark, K. and Nicolai, L.
Nature Communications 13
(1): 1018.
23 February 2022
Extracellular matrix in heart Failure: role of ADAMTS5 in proteoglycan remodeling.
Barallobre-Barreiro, J., Radovits, T., Fava, M., Mayr, U., Lin, W.Y., Ermolaeva, E., Martínez-López, D., Lindberg, E.L., Duregotti, E., Daróczi, L., Hasman, M., Schmidt, L.E., Singh, B., Lu, R., Baig, F., Siedlar, A.M., Cuello, F., Catibog, N., Theofilatos, K., Shah, A.M., Crespo-Leiro, M.G., Doménech, N., Hübner, N., Merkely, B. and Mayr, M.
Circulation 144
(25): 2021-2034.
21 December 2021
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S., Marenholz, I., Esparza-Gordillo, J., Arnau-Soler, A., Pairo-Castineira, E., Rüschendorf, F., Ahluwalia, T.S., Almqvist, C., Arnold, A., Baurecht, H., Bisgaard, H., Bønnelykke, K., Brown, S.J., Bustamante, M., Curtin, J.A., Custovic, A., Dharmage, S.C., Esplugues, A., Falchi, M., Fernandez-Orth, D., Ferreira, M.A.R., Franke, A., Gerdes, S., Gieger, C., Hakonarson, H., Holt, P.G., Homuth, G., Hubner, N., Hysi, P.G., Jarvelin, M.R., Karlsson, R., Koppelman, G.H., Lau, S., Lutz, M., Magnusson, P.K.E., Marks, G.B., Müller-Nurasyid, M., Nöthen, M.M., Paternoster, L., Pennell, C.E., Peters, A., Rawlik, K., Robertson, C.F., Rodriguez, E., Sebert, S., Simpson, A., Sleiman, P.M.A., Standl, M., Stölzl, D., Strauch, K., Szwajda, A., Tenesa, A., Thompson, P.J., Ullemar, V., Visconti, A., Vonk, J.M., Wang, C.A., Weidinger, S., Wielscher, M., Sargent, C.L., Xu, C.J. and Lee, Y.A.
Nature Communications 12
(1): 6618.
16 November 2021
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A., Gärtner, A., Cyganek, L., Tiburcy, M., Tuleta, I., Wellers, L., Folsche, L., Hobbach, A.J., von Frieling-Salewsky, M., Unger, A., Hucke, A., Koser, F., Kassner, A., Sielemann, K., Streckfuß-Bömeke, K., Hasenfuss, G., Goedel, A., Laugwitz, K.L., Moretti, A., Gummert, J.F., Dos Remedios, C.G., Reinecke, H., Knöll, R., van Heesch, S., Hubner, N., Zimmermann, W.H., Milting, H. and Linke, W.A.
Science Translational Medicine 13
(618): eabd3079.
3 November 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Witte, F., Ruiz-Orera, J., Ciolli Mattioli, C., Blachut, S., Adami, E., Schulz, J.F., Schneider-Lunitz, V., Hummel, O., Patone, G., Mücke, M.B., Šilhavý, Jan, Heinig, M., Bottolo, L., Sanchis, D., Vingron, M., Chekulaeva, M., Pravenec, M., Hubner, N. and van Heesch, S.
Genome Biology 22
(1): 191.
28 June 2021
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
Cuello, F., Knaust, A.E., Saleem, U., Loos, M., Raabe, J., Mosqueira, D., Laufer, S., Schweizer, M., Kraak, P., Flenner, F., Ulmer, B.M, Braren, I., Yin, X., Theofilatos, K., Ruiz-Orera, J., Patone, G., Klampe, B., Schulze, T., Piasecki, A., Pinto, Y., Vink, A., Hübner, N., Harding, S., Mayr, M., Denning, C., Eschenhagen, T. and Hansen, A.
EMBO Molecular Medicine 13
(6): e13074.
7 June 2021
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C., Luecken, M.D., Eraslan, G., Sikkema, L., Waghray, A., Heimberg, G., Kobayashi, Y., Vaishnav, E.D., Subramanian, A., Smillie, C., Jagadeesh, K.A., Duong, E.T., Fiskin, E., Triglia, E.T., Ansari, M., Cai, P., Lin, B., Buchanan, J., Chen, S., Shu, J., Haber, A.L., Chung, H., Montoro, D.T., Adams, T., Aliee, H., Allon, S.J., Andrusivova, Z., Angelidis, I., Ashenberg, O., Bassler, K., Bécavin, C., Benhar, I., Bergenstråhle, J., Bergenstråhle, L., Bolt, L., Braun, E., Bui, L.T., Callori, S., Chaffin, M., Chichelnitskiy, E., Chiou, J., Conlon, T.M., Cuoco, M.S., Cuomo, A.S.E., Deprez, M., Duclos, G., Fine, D., Fischer, D.S., Ghazanfar, S., Gillich, A., Giotti, B., Gould, J., Guo, M., Gutierrez, A.J., Habermann, A.C., Harvey, T., He, P., Hou, X., Hu, L., Hu, Y., Jaiswal, A., Ji, L., Jiang, P., Kapellos, T.S., Kuo, C.S., Larsson, L., Leney-Greene, M.A., Lim, K., Litviňuková, M., Ludwig, L.S., Lukassen, S., Luo, W., Maatz, H., Madissoon, E., Mamanova, L., Manakongtreecheep, K., Leroy, S., Mayr, C.H., Mbano, I.M., McAdams, A.M., Nabhan, A.N., Nyquist, S.K., Penland, L., Poirion, O.B., Poli, S., Qi, C.C., Queen, R., Reichart, D., Rosas, I., Schupp, J.C., Shea, C.V., Shi, X., Sinha, R., Sit, R.V., Slowikowski, K., Slyper, M., Smith, N.P., Sountoulidis, A., Strunz, M., Sullivan, T.B., Sun, D., Talavera-López, C., Tan, P., Tantivit, J., Travaglini, K.J., Tucker, N.R., Vernon, K.A., Wadsworth, M.H., Waldman, J., Wang, X., Xu, K., Yan, W., Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27
(3): 546-559.
2 March 2021
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe, C., Ammirati, E., Bozkurt, B., Caforio, A.L.P., Cooper, L.T., Felix, S.B., Hare, J.M., Heidecker, B., Heymans, S., Hübner, N., Kelle, S., Klingel, K., Maatz, H., Parwani, A.S., Spillmann, F., Starling, R.C., Tsutsui, H., Seferovic, P. and Van Linthout, S.
Nature Reviews Cardiology 18
(3): 169-193.
March 2021
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang, H., Hooper, C., Kelly, M., Steeples, V., Simon, J.N., Beglov, J., Azad, A.J., Leinhos, L., Bennett, P., Ehler, E., Kalisch-Smith, J.I., Sparrow, D.B., Fischer, R., Heilig, R., Isackson, H., Ehsan, M., Patone, G., Huebner, N., Davies, B., Watkins, H. and Gehmlich, K.
Basic Research in Cardiology 116
(1): 14.
26 February 2021
Uncovering de novo gene birth in yeast using deep transcriptomics.
Blevins, W.R., Ruiz-Orera, J., Messeguer, X., Blasco-Moreno, B., Villanueva-Cañas, J.L., Espinar, L., Díez, J., Carey, L.B. and Albà, M.M.
Nature Communications 12
(1): 604.
27 January 2021
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Norin, U., Rintisch, C., Meng, L., Forster, F., Ekman, D., Tuncel, J., Klocke, K., Bäcklund, J., Yang, M., Bonner, M.Y, Lahore, G.F., James, J., Shchetynsky, K., Bergquist, M., Gjertsson, I., Hubner, N., Bäckdahl, L. and Holmdahl, R.
Nature Communications 12
(1): 610.
27 January 2021
Cells of the adult human heart.
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C.L., Lindberg, E.L., Kanda, M., Polanski, K., Heinig, M., Lee, M.l, Nadelmann, E.R., Roberts, K., Tuck, L., Fasouli, E.S., DeLaughter, D.M., McDonough, B., Wakimoto, H., Gorham, J.M., Samari, S., Mahbubani, K.T., Saeb-Parsy, K., Patone, G., Boyle, J.J., Zhang, H., Zhang, H., Viveiros, A., Oudit, G.Y., Bayraktar, O., Seidman, J.G., Seidman, C.E., Noseda, M., Hubner, N. and Teichmann, S.A.
Nature 588
(7838): 466-472.
17 December 2020
LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X.M., Figlerowicz, M., Gasser, S.M., Hubner, N., Kjems, J., Knoblich, J.A., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J.C., Marioni, J., Marti-Renom, M.A., Netea, M.G., Nickel, D., Nollmann, M., Novak, H.R., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J.L., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F.J., Torres-Padilla, M.E., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M. and Voet, T.
Nature 587
(7834): 377-386.
19 November 2020
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K.B., Yoshida, M. and Barnes, J.L.
Nature Medicine 26
(5): 681-687.
May 2020
Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M., Ruiz-Orera, J., Albà, M.M. and Eyras, E.
Nature Communications 11
(1): 1768.
14 April 2020
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel, J., Hansen, C.E., Bettoni, C., Vogt, M.A., Lembrich, B., Natsagdorj, R., Huber, G., Brands, J., Schmidt, K., Assmann, J.C., Stölting, I., Saar, K., Sedlacik, J., Fiehler, J., Ludewig, P., Wegmann, M., Feller, N., Richter, M., Müller-Fielitz, H., Walther, T., König, G.M., Kostenis, E., Raasch, W., Hübner, N., Gass, P., Offermanns, S., de Wit, C., Wagner, C.A. and Schwaninger, M.
Proceedings of the National Academy of Sciences of the United States of America 117
(3): 1753-1761.
21 January 2020
Widespread translational control of fibrosis in the human heart by RNA-binding proteins.
Chothani, S., Schäfer, S., Adami, E., Viswanathan, S., Widjaja, A.A., Langley, S.R., Tan, J., Wang, M., Quaife, N.M., Pua, C.J., D'Agostino, G., Shekeran, S.G., George, B.L., Lim, S., Cao, E.Y., van Heesch, S., Witte, F., Felkin, L.E., Christodoulou, E.G., Dong, J., Blachut, S., Patone, G., Barton, P.J.R., Hubner, N., Cook, S.A. and Rackham, O.J.L.
Circulation 140
(11): 937-951.
10 September 2019
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Chen, H., Moreno-Moral, A., Pesce, F., Devapragash, N., Mancini, M., Heng, E.L., Rotival, M., Srivastava, P.K., Harmston, N., Shkura, K., Rackham, O.J.L., Yu, W.P., Sun, X.M., Tee, N.G.Z., Tan, E.L.S., Barton, P.J.R., Felkin, L.E., Lara-Pezzi, E., Angelini, G., Beltrami, C., Pravenec, M., Schafer, A., Bottolo, L., Hubner, N., Emanueli, C., Cook, S.A. and Petretto, E.
Nature Communications 10
(1): 3616.
9 August 2019
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes.
Toepfer, C.N., Sharma, A., Cicconet, M., Garfinkel, A.C., Mücke, M., Neyazi, M., Willcox, J.A.L., Agarwal, R., Schmid, M., Rao, J., Ewoldt, J., Pourquié, O., Chopra, A., Chen, C.S., Seidman, J.G. and Seidman, C.E.
Circulation Research 124
(8): 1172-1183.
12 April 2019
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
Eleven loci with new reproducible genetic associations with allergic disease risk.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Rüschendorf, F., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Karlsson, R., Almqvist, C., Koppelman, G.H. and Paternoster, L.
Journal of Allergy and Clinical Immunology 143
(2): 691-699.
February 2019
E47 modulates hepatic glucocorticoid action.
Hemmer, M.C., Wierer, M., Schachtrup, K., Downes, M., Hübner, N., Evans, R.M. and Uhlenhaut, N.H.
Nature Communications 10
(1): 306.
18 January 2019
Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study.
Marenholz, I., Grosche, S., Rüschendorf, F., Kalb, B., Blumchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Yürek, S., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hubner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 142
(4): 1368-1370.
October 2018
A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y., Eslami, A., van Ginkel, C.D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M.A., Allen, K., Mazer, B., de Groot, H., de Jong, N.W., Gerth van Wijk, R., Dubois, A.E.J., Grosche, S., Ashley, S., Rüschendorf, F., Kalb, B., Beyer, K., Nöthen, M.M., Lee, Y.A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J.S., Melles, R.B., Hong, X., Wang, X., Hui, J., Musk, A.W.B., Hunter, M., James, A.L., Koppelman, G.H., Sandford, A.J., Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141
(4): 1513-1516.
April 2018
IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S., Viswanathan, S., Widjaja, A.A., Lim, W.W., Moreno-Moral, A., DeLaughter, D.M., Ng, B., Patone, G., Chow, K., Khin, E., Tan, J., Chothani, S.P., Ye, L., Rackham, O.J., Ko, N.S., Sahib, N.E., Pua, C.J., Zhen, N.T., Xie, C., Wang, M., Maatz, H., Lim, S., Saar, K., Blachut, S., Petretto, E., Schmidt, S., Putoczki, T., Guimarães-Camboa, N., Wakimoto, H., van Heesch, S., Sigmundsson, K., Lim, S.L., Soon, J.L., Chao, V.T., Chua, Y.L., Tan, T.E., Evans, S.M., Loh, Y.J., Jamal, M.H., Ong, K.K., Chua, K.C., Ong, B.H., Chakaramakkil, M.J., Seidman, J.G., Seidman, C.E., Hubner, N., Sin, K.Y. and Cook, S.A.
Nature 552
(7683): 110-115.
7 December 2017
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Yi, Rueschendorf, F., Esparza-Gordillo, J., Medway, C.W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B.M., Witte, J.S., Hottenga, J.J., Willemsen, G., Zheng, J., Rodriguez, E., Hotze, M., Franke, A., Revez, J.A., Beesley, J., Matheson, M.C., Dharmage, S.C., Bain, L.M., Fritsche, L.G., Gabrielsen, M.E., Balliu, B., Nielsen, J.B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O.L., Løset, M., Abecasis, G.R., Willer, C.J., Arnold, A., Homuth, G., Schmidt, C.O., Thompson, P.J., Martin, N.G., Duffy, D.L., Novak, N., Schulz, H., Karrasch, S., Gieger, C., Strauch, K., Melles, R.B., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K.E., Jansen, R., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Almqvist, C., Karlsson, R., Koppelman, G.H. and Paternoster, L.
Nature Genetics 49
(12): 1752-1757.
December 2017
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Sassi, Y., Avramopoulos, P., Ramanujam, D., Grüter, L., Werfel, S., Giosele, S., Brunner, A.D., Esfandyari, D., Papadopoulou, A.S, De Strooper, B., Hübner, N., Kumarswamy, R., Thum, T., Yin, X., Mayr, M., Laggerbauer, B. and Engelhardt, S.
Nature Communications 8
(1): 1614.
20 November 2017
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Röblitz, H., Yürek, S., Tschirner, S., Hong, X., Wang, X., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hübner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Nature Communications 8
(1): 1056.
20 October 2017
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Heinig, M., Adriaens, M.E., Schafer, S., van Deutekom, H.W.M., Lodder, E.M., Ware, J.S., Schneider, V., Felkin, L.E., Creemers, E.E., Meder, B., Katus, H.A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N.H., George, A.L., Dos Remedios, C., Moreno-Moral, A., Pesce, F., Bauerfeind, A., Rüschendorf, F., Rintisch, C., Petretto, E., Barton, P.J., Cook, S.A., Pinto, Y.M., Bezzina, C.R. and Hubner, N.
Genome Biology 18
(1): 170.
14 September 2017
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Titin-truncating variants affect heart function in disease cohorts and the general population.
Schafer, S., de Marvao, A., Adami, E., Fiedler, L.R., Ng, B., Khin, E., Rackham, O.J.L., van Heesch, S., Pua, C.J., Kui, M., Walsh, R., Tayal, U., Prasad, S.K., Dawes, T.J.W., Ko, N.S.J., Sim, D., Chan, L.L.H., Chin, C.W.L., Mazzarotto, F., Barton, P.J., Kreuchwig, F., de Kleijn, D.P.V., Totman, T., Biffi, C., Tee, N., Rueckert, D., Schneider, V., Faber, A., Regitz-Zagrosek, V., Seidman, J.G., Seidman, C.E., Linke, W.A., Kovalik, J.P., O'Regan, D., Ware, J.S., Hubner, N. and Cook, S.A.
Nature Genetics 49
(1): 46-53.
January 2017
52 genetic loci influencing myocardial mass.
van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M.T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikaeinen, L.P., Polašek, O., Tanaka, T., Arking, D.E., Ulivi, S., Trompet, S., Mueller-Nurasyid, M., Smith, A.V., Dörr, M., Kerr, K.F., Magnani, J.W., Del Greco, M.F., Zhang, W., Nolte, I.M., Silva, C.T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G.R., Adriaens, M.E., Andersen, K., Barnett, P., Bis, J.C., Bodmer, R., Buckley, B.M., Campbell, H., Cannon, M.V., Chakravarti, A., Chen, L.Y., Delitala, A., Devereux, R.B., Doevendans, P.A., Dominiczak, A.F., Ferrucci, L., Ford, I., Gieger, C., Harris, T.B., Haugen, E., Heinig, M., Hernandez, D.G., Hillege, H.L., Hirschhorn, J.N., Hofman, A., Hubner, N., Hwang, S.J., Iorio, A., Kaehoenen, M., Kellis, M., Kolcic, I., Kooner, Is.K., Kooner, J.S., Kors, J.A., Lakatta, E.G., Lage, K., Launer, L.J., Levy, D., Lundby, A., Macfarlane, P.W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A.S., Nutile, T., Okin, P.M., Olsen, J.V., Oostra, B.A., Penninger, J.M., Pennacchio, L.A., Pers, T.H., Perz, S., Peters, A., Pinto, Y.M., Pfeufer, A., Pilia, M.G., Pramstaller, P.P., Prins, B.P., Raitakari, O.T., Raychaudhuri, S., Rice, K.M., Rossin, E.J., Rotter, J.I., Schaefer, S., Schlessinger, D., Schmidt, C.O., Sehmi, J., Sillje, H.H.W., Sinagra, G., Sinner, M.F., Slowikowski, K., Soliman, E.Z., Spector, T.D., Spiering, W., Stamatoyannopoulos, J.A., Stolk, R.P., Strauch, K., Tan, S.T., Tarasov, K.V., Trinh, B., Uitterlinden, A.G., van den Boogaard, M., van Duijn, C.M., van Gilst, W.H., Viikari, J.S., Visscher, P.M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C.X., Westra, H.J., Wijmenga, C., Wolffenbuttel, B.H., Yang, J., Bezzina, C.R., Munroe, P.B., Snieder, H., Wright, A.F., Rudan, I., Boyer, L.A., Asselbergs, F.W., van Veldhuisen, D.J., Stricker, B.H., Psaty, B.M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J.F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J.W., Kääb, S., Gudnason, V., Felix, S.B., Heckbert, S.R., de Boer, R.A., Newton-Cheh, C., Hicks, A.A., Chambers, J.C., Jamshidi, Y., Visel, A., Christoffels, V.M., Isaacs, A., Samani, N.J. and de Bakker, P.I.W.
Journal of the American College of Cardiology 68
(13): 1435-1448.
27 September 2016
Wars2 is a determinant of angiogenesis.
Wang, M., Sips, P., Khin, E., Rotival, M., Sun, X., Ahmed, R., Widjaja, A.A., Schafer, S., Yusoff, P., Choksi, Pe.K., Ko, N.S.J., Singh, M.K., Epstein, D., Guan, Y., Houštěk, J., Mracek, T., Nuskova, H., Mikell, B., Tan, J., Pesce, F., Kolar, F., Bottolo, L., Mancini, M., Hubner, N., Pravenec, M., Petretto, E., MacRae, C. and Cook, S.A.
Nature Communications 7
: 12061.
8 July 2016
Genome-wide polyadenylation maps reveal dynamic mRNA 3'-end formation in the failing human heart.
Creemers, E.E., Bawazeer, A., Ugalde, A.P., van Deutekom, H.W.M., van der Made, I., de Groot, N.E., Adriaens, M.E., Cook, S.A., Bezzina, C.R., Hubner, N., van der Velden, J., Elkon, R., Agami, R. and Pinto, Y.M.
Circulation Research 118
(3): 433-438.
5 February 2016
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O'Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.R., Noethen, M.M., Lau, S., Hübner, N., Lee, Y.A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M. and Weidinger, S.
Nature Genetics 47
(12): 1449-1456.
December 2015
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I., Esparza-Gordillo, J., Rüschendorf, F., Bauerfeind, A., Strachan, D.P., Spycher, B.D., Baurecht, H., Margaritte-Jeannin, P., Sääf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M.C., Li, J., Michel, S., Ang, W.Q., McArdle, W., Arnold, A., Homuth, G., Demenais, F., Bouzigon, E., Söderhäll, C., Pershagen, G., de Jongste, J.C., Postma, D.S., Braun-Fahrlaender, C., Horak, E., Ogorodova, L.M., Puzyrev, V.P., Bragina, E.Y., Hudson, T.J., Morin, C., Duffy, D.L., Marks, G.B., Robertson, C.F., Montgomery, G.W., Musk, B., Thompson, P.J., Martin, N.G., James, A., Sleiman, P., Toskala, E., Rodriguez, E., Fölster-Holst, R., Franke, A., Lieb, W., Gieger, C., Heinzmann, A., Rietschel, E., Keil, T., Cichon, S., Nöthen, M.M., Pennell, C.E., Sly, P.D., Schmidt, C.O., Matanovic, A., Schneider, V., Heinig, M., Hübner, N., Holt, P.G., Lau, S., Kabesch, M., Weidinger, S., Hakonarson, H., Ferreira, M.A.R., Laprise, C., Freidin, M.B., Genuneit, J., Koppelman, G.H., Melén, E., Dizier, M.H., Henderson, A.J. and Lee, Y.A.
Nature Communications 6
: 8804.
6 November 2015
High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J., Gebhardt, M., Heinig, M., Rintisch, C., Schroeder, A., Neuhofer, W., Hilgers, K., Manzel, A., Schwartz, C., Kleinewietfeld, M., Voelkl, J., Schatz, V., Linker, R.A., Lang, F., Voehringer, D., Wright, M.D., Hubner, N., Dechend, R., Jantsch, J., Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125
(11): 4223-4238.
2 November 2015
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.
Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.J., Xiao, F.L., Lee, Y.A., Franke, A. and Weidinger, S.
Journal of Allergy and Clinical Immunology 136
(3): 802-806.
September 2015
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T., Chopra, A., Nafissi, N., Polacheck, W.J., Benson, C.C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C.C., Haghighi, A., Homsy, J., Hubner, N., Church, G., Cook, S.A., Linke, W.A., Chen, C.S., Seidman, J.G. and Seidman, C.E.
Science 349
(6251): 982-986.
28 August 2015
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
Lim, H.W., Uhlenhaut, N.H., Rauch, A., Weiner, J., Hübner, S., Hübner, N., Won, K.J., Lazar, M.A., Tuckermann, J. and Steger, D.J.
Genome Research 25
(6): 836-844.
June 2015
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47
(6): 647-653.
June 2015
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Schafer, S., Adami, E., Heinig, M., Costa Rodrigues, K.E., Kreuchwig, F., Silhavy, J., van Heesch, S., Simaite, D., Rajewsky, N., Cuppen, E., Pravenec, M., Vingron, M., Cook, S.A. and Hubner, N.
Nature Communications 6
: 7200.
26 May 2015
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M., Ware, J.S., Herman, D.S., Schafer, S., Baksi, J., Bick, A.G., Buchan, R.J., Walsh, R., John, S., Wilkinson, S., Mazzarotto, F., Felkin, L.E., Gong, S., MacArthur, J.A.L., Cunningham, F., Flannick, J., Gabriel, S.B., Altshuler, D.M., Macdonald, P.S., Heinig, M., Keogh, A.M., Hayward, C.S., Banner, N.R., Pennell, D.J., O'Regan, D.P., San, T.R., de Marvao, A., Dawes, T.J.W., Gulati, A., Birks, E.J., Yacoub, M.H., Radke, M., Gotthardt, M., Wilson, J.G., O'Donnell, C.J., Prasad, S.K., Barton, P.J.R., Fatkin, D., Hubner, N., Seidman, J.G., Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7
(270): 270ra6.
14 January 2015
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O'Regan, G.M., Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J. and Brown, S.J.
American Journal of Human Genetics 96
(1): 104-120.
8 January 2015
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C., Kind, B., Reijns, M.A.M., Berndt, N., Martinez-Bueno, M., Wolf, C., Tüngler, V., Chara, O., Lee, Y.A., Hübner, N., Bicknell, L., Blum, S., Krug, C., Schmidt, F., Kretschmer, S., Koss, S., Astell, K.R., Ramantani, G., Bauerfeind, A., Morris, D.L., Cunninghame Graham, D.S., Bubeck, D., Leitch, A., Ralston, S.H., Blackburn, E.A., Gahr, M., Witte, T., Vyse, T.J., Melchers, I., Mangold, E., Nöthen, M.M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J.D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M.E., Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125
(1): 413-424.
2 January 2015
Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes.
Schubert, J., Siekierska, A., Langlois, M., May, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J.R., de Kovel, C.G.F., Thiele, H., Konrad, K., Kawalia, A., Toliat, M.R., Sander, T., Rueschendorf, F., Caliebe, A., Nagel, I., Kohl, B., Kecskes, A., Jacmin, M., Hardies, K., Weckhuysen, S., Riesch, E., Dorn, T., Brilstra, E.H., Baulac, S., Moller, R.S., Hjalgrim, H., Koeleman, B.P.C., Jurkat-Rott, K., Lehman-Horn, F., Roach, J.C., Glusman, G., Hood, L., Galas, D.J., Martin, B., de Witte, P.A.M., Biskup, S., De Jonghe, P., Helbig, I., Balling, R., Nuernberg, P., Crawford, A.D., Esguerra, C.V., Weber, Y.G. and Lerche, H.
Nature Genetics 46
(12): 1327-1332.
December 2014
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124
(8): 3419-3430.
1 August 2014
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal, M., Zheng, Y., Hultin, S., Audebert, S., van Harn, T., Johnsson, P., Lenander, C., Fritz, N., Mieth, C., Corcoran, M., Lembo, F., Hallstroem, M., Hartman, J., Mazure, N.M., Weide, T., Grander, D., Borg, J.P., Uhlen, P. and Holmgren, L.
Nature Communications 5
: 4557.
1 August 2014
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
Motamedi, F.J., Badro, D.A., Clarkson, M., Rita Lecca, M., Bradford, S.T., Buske, F.A., Saar, K., Hübner, N., Bräendli, A.W. and Schedl, A.
Nature Communications 5
: 4444.
17 July 2014
Natural variation of histone modification and its impact on gene expression in the rat genome.
Rintisch, C., Heinig, M., Bauerfeind, A., Schafer, S., Mieth, C., Patone, G., Hummel, O., Chen, W., Cook, S., Cuppen, E., Colomé-Tatché, M., Johannes, F., Jansen, R.C., Neil, H., Werner, M., Pravenec, M., Vingron, M. and Hubner, N.
Genome Research 24
(6): 942-953.
June 2014
Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A.
Auer, F., Rueschendorf, F., Gombert, M., Husemann, P., Ginzel, S., Izraeli, S., Harit, M., Weintraub, M., Weinstein, O.Y., Lerer, I., Stepensky, P., Borkhardt, A. and Hauer, J.
Leukemia 28
(5): 1136-1138.
May 2014
Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Aksoy, I., Giudice, V., Delahaye, E., Wianny, F., Aubry, M., Mure, M., Chen, J., Jauch, R., Bogu, G.K., Nolden, T., Himmelbauer, H., Doss, M.X., Sachinidis, A., Schulz, H., Hummel, O., Martinelli, P., Hübner, N., Stanton, L.W., Real, F.X., Bourillot, P.Y. and Savatier, P.
Nature Communications 5
: 3719.
28 April 2014
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
Meder, B., Rühle, F., Weis, T., Homuth, G., Keller, A., Franke, J., Peil, B., Bermejo, J.L., Frese, K., Huge, A., Witten, A., Vogel, B., Haas, J., Völker, U., Ernst, F., Teumer, A., Ehlermann, P., Zugck, C., Friedrichs, F., Kroemer, H., Dörr, M., Hoffmann, W., Maisch, B., Pankuweit, S., Ruppert, V., Scheffold, T., Kühl, U., Schultheiss, H.P., Kreutz, R., Ertl, G., Angermann, C., Charron, P., Villard, E., Gary, F., Isnard, R., Komajda, M., Lutz, M., Meitinger, T., Sinner, M.F., Wichmann, H.E., Krawczak, M., Ivandic, B., Weichenhan, D., Gelbrich, G., El-Mokhtari, N.E., Schreiber, S., Felix, S.B., Hasenfuß, G., Pfeufer, A., Hübner, N., Kääb, S., Arbustini, E., Rottbauer, W., Frey, N., Stoll, M. and Katus, H.A.
European Heart Journal 35
(16): 1069-1077.
21 April 2014
TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D., Rocca, E., Oonk, A.M.M., Schulz, H., Rohde, E., Bednarsch, J., Feenstra, I., Pennings, R.J.E., Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124
(3): 1214-1227.
3 March 2014
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α.
Brooke, M.A., Longhurst, H.J., Plagnol, V., Kirkby, N.S., Mitchell, J.A., Rüschendorf, F., Warner, T.D., Kelsell, D.P. and MacDonald, T.T.
Gut 63
(1): 96-104.
January 2014
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur, S.S., Diaz, A.G., Maratou, K., Sarkis, A., Rotival, M., Game, L., Tschannen, M.R., Kaisaki, P.J., Otto, G.W., John Ma, M.C., Keane, T.M., Hummel, O., Saar, K., Chen, W., Guryev, V., Gopalakrishnan, K., Garrett, M.R., Joe, B., Citterio, L., Bianchi, G., McBride, M., Dominiczak, A., Adams, D.J., Serikawa, T., Flicek, P., Cuppen, E., Hubner, N., Petretto, E., Gauguier, D., Kwitek, A., Jacob, H. and Aitman, T.J.
Cell 154
(3): 691-703.
1 August 2013
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo, J., Schaarschmidt, H., Liang, L., Cookson, W., Bauerfeind, A., Lee-Kirsch, M.A., Nemat, K., Henderson, J., Paternoster, L., Harper, J.L., Mangold, E., Nothen, M.M., Rüschendorf, F., Kerscher, T., Marenholz, I., Matanovic, A., Lau, S., Keil, T., Bauer, C.P., Kurek, M., Ciechanowicz, A., Macek, M., Franke, A., Kabesch, M., Hubner, N., Abecasis, G., Weidinger, S., Moffatt, M. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 132
(2): 371-377.
August 2013
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Arndt, A.K., Schaefer, S., Drenckhahn, J.D., Sabeh, M.K., Plovie, E.R., Caliebe, A., Klopocki, E., Musso, G., Werdich, A.A., Kalwa, H., Heinig, M., Padera, R.F., Wassilew, K., Bluhm, J., Harnack, C., Martitz, J., Barton, P.J., Greutmann, M., Berger, F., Huebner, N., Siebert, R., Kramer, H.H., Cook, S.A., Macrae, C.A. and Klaassen, S.
American Journal of Human Genetics 93
(1): 67-77.
11 July 2013
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud, A., Hermsen, R., Guryev, V., Stridh, P., Graham, D., McBride, M.W., Foroud, T., Calderari, S., Diez, M., Ockinger, J., Beyeen, A.D., Gillett, A., Abdelmagid, N., Guerreiro-Cacais, A.O., Jagodic, M., Tuncel, J., Norin, U., Beattie, E., Huynh, N., Miller, W.H., Koller, D.L., Alam, I., Falak, S., Osborne-Pellegrin, M., Martinez-Membrives, E., Canete, T., Blazquez, G., Vicens-Costa, E., Mont-Cardona, C., Diaz-Moran, S., Tobena, A., Hummel, O., Zelenika, D., Saar, K., Patone, G., Bauerfeind, A., Bihoreau, M.T., Heinig, M., Lee, Y.A., Rintisch, C., Schulz, H., Wheeler, D.A., Worley, K.C., Muzny, D.M., Gibbs, R.A., Lathrop, M., Lansu, N., Toonen, P., Ruzius, F.P., de Bruijn, E., Hauser, H., Adams, D.J., Keane, T., Atanur, S.S., Aitman, T.J., Flicek, P., Malinauskas, T., Jones, E.Y., Ekman, D., Lopez-Aumatell, R., Dominiczak, A.F., Johannesson, M., Holmdahl, R., Olsson, T., Gauguier, D., Hubner, N., Fernandez-Teruel, A., Cuppen, E., Mott, R. and Flint, J.
Nature Genetics 45
(7): 767-775.
July 2013
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M., Takahashi, A., Nakamura, Y., Tsoi, L.C., Stuart, P., Elder, J.T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M.M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B.O., Duerr, R.H., Büning, C., Brandt, S., Glas, J., McAleer, M.A., Fahy, C.M., Kabesch, M., Brown, S., McLean, W.H.I., Irvine, A.D., Schreiber, S., Lee, Y.A., Franke, A. and Weidinger, S.
Nature Genetics 45
(7): 808-812.
July 2013
Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes.
Uhlenhaut, N.H., Barish, G.D., Yu, R.T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N. and Evans, R.M.
Molecular Cell 49
(1): 158-171.
10 January 2013
A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G., Rump, A., Schulz, H., Stricker, S., Schulze, L., Platzer, K., Aydin, A., Tinschert, S., Goldring, M.B., Luft, F.C. and Bähring, S.
Journal of Clinical Investigation 122
(11): 3990-4002.
1 November 2012
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.
Dizier, M.H., Margaritte-Jeannin, P., Madore, A.M., Esparza-Gordillo, J., Moffatt, M.F., Corda, E., Monier, F., Guilloud-Bataille, M., Franke, A., Weidinger, S., Annesi-Maesano, I., Just, J., Pin, I., Kauffmann, F., Cookson, W., Lee, Y.A., Laprise, C., Lathrop, M., Bouzigon, E. and Demenais, F.
Journal of Allergy and Clinical Immunology 129
(6): 1547-1553.
June 2012
A genetic basis for mechanosensory traits in humans.
Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G., Schiska, D., Jaijo, T., Rueschendorf, F., Saar, K., Jordan, J., Millan, J.M., Gross, M. and Lewin, G.R.
PLoS Biology 10
(5): e1001318.
1 May 2012
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Lincoln, S.E., Parrish, A.M., Dauksaite, V., Vakeel, P., Klaassen, S., Gerull, B., Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R., Perrot, A., Ozcelik, C., Saar, K., Hubner, N. and Gotthardt, M.
Nature Medicine 18
(5): 766-773.
May 2012
Combined RNAi and localization for functionally dissecting long noncoding RNAs.
Chakraborty, D., Kappei, D., Theis, M., Nitzsche, A., Ding, L., Paszkowski-Rogacz, M., Surendranath, V., Berger, N., Schulz, H., Saar, K., Hubner, N. and Buchholz, F.
Nature Methods 9
(4): 360-362.
12 February 2012
Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss.
Baumann, M., Giunta, C., Krabichler, B., Rueschendorf, F., Zoppi, N., Colombi, M., Bittner, R.E., Quijano-Roy, S., Muntoni, F., Cirak, S., Schreiber, G., Zou, Y., Hu, Y., Romero, N.B., Carlier, R.Y., Amberger, A., Deutschmann, A., Straub, V., Rohrbach, M., Steinmann, B., Rostasy, K., Karall, D., Boennemann, C.G., Zschocke, J. and Fauth, C.
American Journal of Human Genetics 90
(2): 201-216.
10 February 2012
Inflammatory skin and bowel disease linked to ADAM17 deletion.
Blaydon, D.C., Biancheri, P., Di, W.L., Plagnol, V., Cabral, R.M., Brooke, M.A., van Heel, D.A., Ruschendorf, F., Toynbee, M., Walne, A., O'Toole, E.A., Martin, J.E., Lindley, K., Vulliamy, T., Abrams, D.J., MacDonald, T.T., Harper, J.I. and Kelsell, D.P.
New England Journal of Medicine 365
(16): 1502-1508.
20 October 2011
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe, C., Ye, J., Ahmed, R., Sun, X.M., Serafin, A., Ware, J., Bottolo, L., Muckett, P., Canas, X., Zhang, J., Rowe, G.C., Buchan, R., Lu, H., Braithwaite, A., Mancini, M., Hauton, D., Marti, R., Garcia-Arumi, E., Hubner, N., Jacob, H., Serikawa, T., Zidek, V., Papousek, F., Kolar, F., Cardona, M., Ruiz-Meana, M., Garcia-Dorado, D., Comella, J.X., Felkin, L.E., Barton, P.J., Arany, Z., Pravenec, M., Petretto, E., Sanchis, D. and Cook, S.A.
Nature 478
(7367): 114-118.
6 October 2011
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S.R., Bauerfeind, A., Hummel, O., Lee, Y.A., Paskas, S., Rintisch, C., Saar, K., Cooper, J., Buchan, R., Gray, E.E., Cyster, J.G., Braund, P., Gracey, J., Krishnan, U., Moore, J.S., Nelson, C.P., Pollard, H., Attwood, T., Crisp-Hihn, A., Foad, N., Jolley, J., Lloyd-Jones, H., Muir, D., Murray, E., O'Leary, K., Rankin, A., Sambrook, J., Godfroy, T., Brocheton, J., Proust, C., Schmitz, G., Heimerl, S., Lugauer, I., Belz, S., Gulde, S., Linsel-Nitschke, P., Sager, H., Schroeder, L., Lundmark, P., Syvannen, A.C., Neudert, J., Scholz, M., Deloukas, P., Gray, E., Gwilliams, R., Niblett, D., Erdmann, J., Hengstenberg, C., Maouche, S., Ouwehand, W.H., Rice, C.M., Samani, N.J., Schunkert, H., Goodall, A.H., Schulz, H., Roider, H.G., Vingron, M., Blankenberg, S., Muenzel, T., Zeller, T., Szymczak, S., Ziegler, A., Tiret, L., Smyth, D.J., Pravenec, M., Aitman, T.J., Cambien, F., Clayton, D., Todd, J.A., Huebner, N. and Cook, S.A.
Nature 467
(7314): 460-464.
23 September 2010
The genome sequence of the spontaneously hypertensive rat: analysis and functional significance.
Atanur, S.S., Birol, I., Guryev, V., Hirst, M., Hummel, O., Morrissey, C., Behmoaras, J., Fernandez-Suarez, X.M., Johnson, M.D., McLaren, W.M., Patone, G., Petretto, E., Plessy, C., Rockland, K.S., Rockland, C., Saar, K., Zhao, Y., Carninci, P., Flicek, P., Kurtz, T., Cuppen, E., Pravenec, M., Huebner, N., Jones, S.J., Birney, E. and Aitman, T.J.
Genome Research 20
(6): 791-803.
June 2010
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A., Monet-Lepretre, M., Gosele, C., Baron-Menguy, C., Hammes, A., Schmidt, S., Lemaire-Carrette, B., Domenga, V., Schedl, A., Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120
(2): 433-445.
1 February 2010
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y., Liska, F., Gosele, C., Sedova, L., Kren, V., Krenova, D., Ivics, Z., Huebner, N. and Izsvak, Z.
Genome Research 20
(1): 19-27.
January 2010
CLCN2 variants in idiopathic generalized epilepsy.
Kleefuss-Lie, A., Friedl, W., Cichon, S., Haug, K., Warnstedt, M., Alekov, A., Sander, T., Ramirez, A., Poser, B., Maljevic, S., Hebeisen, S., Kubisch, C., Rebstock, J., Horvath, S., Hallmann, K., Dullinger, J.S., Rau, B., Haverkamp, F., Beyenburg, S., Schulz, H., Janz, D., Giese, B., Muller-Newen, G., Propping, P., Elger, C.E., Fahlke, C. and Lerche, H.
Nature Genetics 41
(9): 954-955.
September 2009
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Henneke, M., Diekmann, S., Ohlenbusch, A., Kaiser, J., Engelbrecht, V., Kohlschuetter, A., Kraetzner, R., Madruga-Garrido, M., Mayer, M., Opitz, L., Rodriguez, D., Rueschendorf, F., Schumacher, J., Thiele, H., Thoms, S., Steinfeld, R., Nuernberg, P. and Gaertner, J.
Nature Genetics 41
(7): 773-775.
July 2009
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Ding, L., Paszkowski-Rogacz, M., Nitzsche, A., Slabicki, M.M., Heninger, A.K., Vries, I.D., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., Huebner, N., Doss, M.X., Sachinidis, A., Hescheler, J., Iacone, R., Anastassiadis, K., Stewart, A.F., Pisabarro, M.T., Caldarelli, A., Poser, I., Theis, M. and Buchholz, F.
Cell Stem Cell 4
(5): 403-415.
8 May 2009
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo, J., Weidinger, S., Foelster-Holst, R., Bauerfeind, A., Rueschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., Huebner, N., Wahn, U., Schreiber, S., Franke, A., Vogler, R., Heath, S., Baurecht, H., Novak, N., Rodriguez, E., Illig, T., Lee-Kirsch, M.A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M., Lee, Y.A. and Ruether, A.
Nature Genetics 41
(5): 596-601.
May 2009
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.
Huck, K., Feyen, O., Niehues, T., Rueschendorf, F., Huebner, N., Laws, H.J., Telieps, T., Knapp, S., Wacker, H.H., Meindl, A., Jumaa, H. and Borkhardt, A.
Journal of Clinical Investigation 119
(5): 1350-1358.
May 2009
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
Heinz-Erian, P., Mueller, T., Krabichler, B., Schranz, M., Becker, C., Rueschendorf, F., Nuernberg, P., Rossier, B., Vujic, M., Booth, I.W., Holmberg, C., Wijmenga, C., Grigelioniene, G., Kneepkens, C.M., Rosipal, S., Mistrik, M., Kappler, M., Michaud, L., Doczy, L.C., Siu, V.M., Krantz, M., Zoller, H., Utermann, G. and Janecke, A.R.
American Journal of Human Genetics 84
(2): 188-196.
13 February 2009
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig, I., Mefford, H.C., Sharp, A.J., Guipponi, M., Fichera, M., Franke, A., Muhle, H., de Kovel, C., Baker, C., von Spiczak, S., Kron, K.L., Steinich, I., Kleefuss-Lie, A.A., Leu, C., Gaus, V., Schmitz, B., Klein, K.M., Reif, P.S., Rosenow, F., Weber, Y., Lerche, H., Zimprich, F., Urak, L., Fuchs, K., Feucht, M., Genton, P., Thomas, P., Visscher, F., de Haan, G.J., Moller, R.S., Hjalgrim, H., Luciano, D., Wittig, M., Nothnagel, M., Elger, C.E., Nuernberg, P., Romano, C., Malafosse, A., Koeleman, B.P.C., Lindhout, D., Stephani, U., Schreiber, S., Eichler, E.E. and Sander, T.
Nature Genetics 41
(2): 160-162.
February 2009
The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations.
Lang, U.E., Hellweg, R., Sander, T. and Gallinat, J.
Molecular Psychiatry 14
(2): 120-122.
February 2009
PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.
Decker, E., Stellzig-Eisenhauer, A., Fiebig, B.S., Rau, C., Kress, W., Saar, K., Rueschendorf, F., Huebner, N., Grimm, T. and Weber, B.H.
American Journal of Human Genetics 83
(6): 781-786.
12 December 2008
A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults.
Gotthardt, D., Runz, H., Keitel, V., Fischer, C., Flechtenmacher, C., Wirtenberger, M., Weiss, K.H., Imparato, S., Braun, A., Hemminki, K., Stremmel, W., Rueschendorf, F., Stiehl, A., Kubitz, R., Burwinkel, B., Schirmacher, P., Knisely, A.S., Zschocke, J. and Sauer, P.
Hepatology 48
(4): 1157-1166.
October 2008
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
Pravenec, M., Churchill, P.C., Churchill, M.C., Viklicky, O., Kazdova, L., Aitman, T.J., Petretto, E., Huebner, N., Wallace, C.A., Zimdahl, H., Zidek, V., Landa, V., Dunbar, J., Bidani, A., Griffin, K., Qi, N., Maxova, M., Kren, V., Mlejnek, P., Wang, J. and Kurtz, T.W.
Nature Genetics 40
(8): 952-954.
August 2008
Progress and prospects in rat genetics: a community view.
Aitman, T.J., Critser, J.K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X.M., Flint, J., Gauguier, D., Geurts, A.M., Gould, M., Harris, P.C., Holmdahl, R., Huebner, N., Izsvak, Z., Jacob, H.J., Kuramoto, T., Kwitek, A.E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J.D., Szpirer, C., Twigger, S.N., Voigt, B. and Worley, K.C.
Nature Genetics 40
(5): 516-22.
May 2008
Distribution and functional impact of DNA copy number variation in the rat.
Guryev, V., Saar, K., Adamovic, T., Verheul, M., van Heesch, S., Cook, S., Pravenec, M., Aitman, T., Jacob, H., Shull, J.D., Huebner, N. and Cuppen, E.
Nature Genetics 40
(5): 538-545.
May 2008
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J., Fischer, J., Paskas, S., Heinig, M., Schulz, H., Goesele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., Gross, V., Hummel, O., Maatz, H., Patone, G., Saar, K., Vingron, M., Weldon, S.M., Lindpaintner, K., Hammock, B.D., Rohde, K., Dietz, R., Cook, S.A., Schunck, W.H., Luft, F.C. and Huebner, N.
Nature Genetics 40
(5): 529-537.
May 2008
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
Petretto, E., Sarwar, R., Grieve, I., Lu, H., Kumaran, M.K., Muckett, P.J., Mangion, J., Schroen, B., Benson, M., Punjabi, P.P., Prasad, S.K., Pennell, D.J., Kiesewetter, C., Tasheva, E.S., Corpuz, L.M., Webb, M.D., Conrad, G.W., Kurtz, T.W., Kren, V., Fischer, J., Huebner, N., Pinto, Y.M., Pravenec, M., Aitman, T.J. and Cook, S.A.
Nature Genetics 40
(5): 546-552.
May 2008
SNP and haplotype mapping for genetic analysis in the rat.
Saar, K., Beck, A., Bihoreau, M.T., Birney, E., Brocklebank, D., Chen, Y., Cuppen, E., Demonchy, S., Dopazo, J., Flicek, P., Foglio, M., Fujiyama, A., Gut, I.G., Gauguier, D., Guigo, R., Guryev, V., Heinig, M., Hummel, O., Jahn, N., Klages, S., Kren, V., Kube, M., Kuhl, H., Kuramoto, T., Kuroki, Y., Lechner, D., Lee, Y.A., Lopez-Bigas, N., Lathrop, G.M., Mashimo, T., Medina, I., Mott, R., Patone, G., Perrier-Cornet, J.A., Platzer, M., Pravenec, M., Reinhardt, R., Sakaki, Y., Schilhabel, M., Schulz, H., Serikawa, T., Shikhagaie, M., Tatsumoto, S., Taudien, S., Toyoda, A., Voigt, B., Zelenika, D., Zimdahl, H. and Huebner, N.
Nature Genetics 40
(5): 560-566.
May 2008
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Pasternack, S.M., von Kuegelgen, I., Aboud, K.A., Lee, Y.A., Rueschendorf, F., Voss, K., Hillmer, A.M., Molderings, G.J., Franz, T., Ramirez, A., Nuernberg, P., Noethen, M.M. and Betz, R.C.
Nature Genetics 40
(3): 329-334.
March 2008
Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians.
Kayser, M., Lao, O., Saar, K., Brauer, S., Wang, X., Nuernberg, P., Trent, R.J. and Stoneking, M.
American Journal of Human Genetics 82
(1): 194-198.
10 January 2008
Association and linkage of allelic variants of the dopamine transporter gene in ADHD.
Friedel, S., Saar, K., Sauer, S., Dempfle, A., Walitza, S., Renner, T., Romanos, M., Freitag, C., Seitz, C., Palmason, H., Scherag, A., Windemuth-Kieselbach, C., Schimmelmann, B.G., Wewetzer, C., Meyer, J., Warnke, A., Lesch, K.P., Reinhardt, R., Herpertz-Dahlmann, B., Linder, M., Hinney, A., Remschmidt, H., Schaefer, H., Konrad, K., Huebner, N. and Hebebrand, J.
Molecular Psychiatry 12
(10): 923-933.
October 2007
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch, M.A., Gong, M., Chowdhury, D., Senenko, L., Engel, K., Lee, Y.A., de Silva, U., Bailey, S.L., Witte, T., Vyse, T.J., Kere, J., Pfeiffer, C., Harvey, S., Wong, A., Koskenmies, S., Hummel, O., Rohde, K., Schmidt, R.E., Dominiczak, A.F., Gahr, M., Hollis, T., Perrino, F.W., Lieberman, J. and Huebner, N.
Nature Genetics 39
(9): 1065-1067.
September 2007
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C., Marenholz, I., Kerscher, T., Rueschendorf, F., Esparza-Gordillo, J., Worm, M., Gruber, C., Mayr, G., Albrecht, M., Rohde, K., Schulz, H., Wahn, U., Huebner, N. and Lee, Y.A.
PLoS Biology 5
(9): e242.
September 2007
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
Leach, N.T., Sun, Y., Michaud, S., Zheng, Y., Ligon, K.L., Ligon, A.H., Sander, T., Korf, B.R., Lu, W., Harris, D.J., Gusella, J.F., Maas, R.L., Quade, B.J., Cole, A.J., Kelz, M.B. and Morton, C.C.
American Journal of Human Genetics 80
(4): 792-799.
April 2007
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Blaydon, D.C., Ishii, Y., O'Toole, E.A., Unsworth, H.C., Teh, M.T., Rueschendorf, F., Sinclair, C., Hopsu-Havu, V.K., Tidman, N., Moss, C., Watson, R., de Berker, D., Wajid, M., Christiano, A.M. and Kelsell, D.P.
Nature Genetics 38
(11): 1245-1247.
November 2006
Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.
Lee-Kirsch, M.A., Gong, M., Schulz, H., Rüschendorf, F., Stein, A., Pfeiffer, C., Ballarini, A., Gahr, M., Hubner, N. and Linne, M.
American Journal of Human Genetics 79
(4): 731-737.
October 2006
Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis.
Maerschenz, S., Endres, A.S., Brinckmann, A., Heise, T., Kristiansen, G., Nuernberg, P., Krueger, D.H., Guenther, S. and Meisel, H.
Gastroenterology 131
(3): 765-780.
September 2006
Reply to "Normalization procedures and detection of linkage signal in genetical-genomics experiments".
Petretto, E., Mangion, J., Cook, S.A., Aitman, T.J., Pravenec, M., Schulz, H., Fischer, J. and Hubner, N.
Nature Genetics 38
(8): 858-859.
August 2006
A genome-wide scan for attention-deficit/hyperactivity disorder in 155 german sib-pairs.
Hebebrand, J., Dempfle, A., Saar, K., Thiele, H., Herpertz-Dahlmann, B., Linder, M., Kiefl, H., Remschmidt, H., Hemminger, U., Warnke, A., Knoelker, U., Heiser, P., Friedel, S., Hinney, A., Schaefer, H., Nuernberg, P. and Konrad, K.
Molecular Psychiatry 11
(2): 196-205.
February 2006
Expressing physiology.
Hubner, N.
Nature Genetics 38
(2): 140-141.
February 2006
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7
(2): 207-215.
February 2006
Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator.
Thiel, C.T., Horn, D., Zabel, B., Ekici, A.B., Salinas, K., Gebhart, E., Rueschendorf, F., Sticht, H., Spranger, J., Mueller, D., Zweier, C., Schmitt, M.E., Reis, A. and Rauch, A.
American Journal of Human Genetics 77
(5): 795-806.
1 November 2005
Role of endocytosis in cellular uptake of sex steroids.
Hammes, A., Andreassen, T.K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F.J., Luppa, P.B., Nykjaer, A. and Willnow, T.E.
Cell 122
(5): 751-762.
9 September 2005
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
Hubner, N., Wallace, C.A., Zimdahl, H., Petretto, E., Schulz, H., Maciver, F., Mueller, M., Hummel, O., Monti, J., Zidek, V., Musilova, A., Kren, V., Causton, H., Game, L., Born, G., Schmidt, S., Mueller, A., Cook, S.A., Kurtz, T.W., Whittaker, J., Pravenec, M. and Aitman, T.J.
Nature Genetics 37
(3): 243-253.
1 March 2005
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.
Metherell, L.A., Chapple, J.P., Cooray, S., David, A., Becker, C., Rueschendorf, F., Naville, D., Begeot, M., Khoo, B., Nuernberg, P., Huebner, A., Cheetham, M.E. and Clark, A.J.L.
Nature Genetics 37
(2): 166-170.
1 January 2005
Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.
Uhlenberg, B., Schuelke, M., Rueschendorf, F., Ruf, N., Kaindl, A.M., Henneke, M., Thiele, H., Stoltenburg-Didinger, G., Aksu, F., Topaloglu, H., Nuernberg, P., Huebner, C., Weschke, B. and Gaertner, J.
American Journal of Human Genetics 75
(2): 251-260.
August 2004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs, R.A., Weinstock, G.M., Metzker, M.L., Muzny, D.M., Sodergren, E.J., Scherer, S., Scott, G., Steffen, D., Worley, K.C., Burch, P.E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R., Holt, R.A., Adams, M.D., Amanatides, P.G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans, C.A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C.L., Nguyen, T., Pfannkoch, C.M., Sitter, C., Sutton, G.G., Venter, J.C., Woodage, T., Smith, D., Lee, H.M., Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss, R.B., Dunn, D.M., Green, E.D., Blakesley, R.W., Bouffard, G.G., de Jong, P.J., Osoegawa, K., Zhu, B., Marra, M., Schein, J., Bosdet, I., Fjell, C., Jones, S., Krzywinski, M., Mathewson, C., Siddiqui, A., Wye, N., McPherson, J., Zhao, S., Fraser, C.M., Shetty, J., Shatsman, S., Geer, K., Chen, Y., Abramzon, S., Nierman, W.C., Havlak, P.H., Chen, R., Durbin, K.J., Egan, A., Ren, Y., Song, X.Z., Li, B., Liu, Y., Qin, X., Cawley, S., Worley, K.C., Cooney, A.J., D'Souza, L.M., Martin, K., Wu, J.Q., Gonzalez-Garay, M.L., Jackson, A.R., Kalafus, K.J., McLeod, M.P., Milosavljevic, A., Virk, D., Volkov, A., Wheeler, D.A., Zhang, Z., Bailey, J.A., Eichler, E.E., Tuzun, E., Birney, E., Mongin, E., Ureta-Vidal, A., Woodwark, C., Zdobnov, E., Bork, P., Suyama, M., Torrents, D., Alexandersson, M., Trask, B.J., Young, J.M., Huang, H., Wang, H., Xing, H., Daniels, S., Gietzen, D., Schmidt, J., Stevens, K., Vitt, U., Wingrove, J., Camara, F., Alba, M.M., Abril, J.F., Guigo, R., Smit, A., Dubchak, I., Rubin, E.M., Couronne, O., Poliakov, A., Hübner, N., Ganten, D., Goesele, C., Hummel, O., Kreitler, T., Lee, Y.A., Monti, J., Schulz, H., Zimdahl, H., Himmelbauer, H., Lehrach, H., Jacob, H.J., Bromberg, S., Gullings-Handley, J., Jensen-Seaman, M.I., Kwitek, A.E., Lazar, J., Pasko, D., Tonellato, P.J., Twigger, S., Ponting, C.P., Duarte, J.M., Rice, S., Goodstadt, L., Beatson, S.A., Emes, R.D., Winter, E.E., Webber, C., Brandt, P., Nyakatura, G., Adetobi, M., Chiaromonte, F., Elnitski, L., Eswara, P., Hardison, R.C., Hou, M., Kolbe, D., Makova, K., Miller, W., Nekrutenko, A., Riemer, C., Schwartz, S., Taylor, J., Yang, S., Zhang, Y., Lindpaintner, K., Andrews, T.D., Caccamo, M., Clamp, M., Clarke, L., Curwen, V., Durbin, R., Eyras, E., Searle, S.M., Cooper, G.M., Batzoglou, S., Brudno, M., Sidow, A., Stone, E.A., Venter, J.C., Payseur, B.A., Bourque, G., Lopez-Otin, C., Puente, X.S., Chakrabarti, K., Chatterji, S., Dewey, C., Pachter, L., Bray, N., Yap, V.B., Caspi, A., Tesler, G., Pevzner, P.A., Haussler, D., Roskin, K.M., Baertsch, R., Clawson, H., Furey, T.S., Hinrichs, A.S., Karolchik, D., Kent, W.J., Rosenbloom, K.R., Trumbower, H., Weirauch, M., Cooper, D.N., Stenson, P.D., Ma, B., Brent, M., Arumugam, M., Shteynberg, D., Copley, R.R., Taylor, M.S., Riethman, H., Mudunuri, U., Peterson, J., Guyer, M., Felsenfeld, A., Old, S., Mockrin, S. and Collins, F.
Nature 428
(6982): 493-521.
1 April 2004
Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome.
Krzywinski, M., Wallis, J., Gösele, C., Bosdet, I., Chiu, R., Graves, T., Hummel, O., Layman, D., Mathewson, C., Wye, N., Zhu, B., Albracht, D., Asano, J., Barber, S., Brown-John, M., Chan, S., Chand, S., Cloutier, A., Davito, J., Fjell, C., Gaige, T., Ganten, D., Girn, N., Guggenheimer, K., Himmelbauer, H., Kreitler, T., Leach, S., Lee, D., Lehrach, H., Mayo, M., Mead, K., Olson, T., Pandoh, P., Prabhu, A.L., Shin, H., Taenzer, S., Thompson, J., Tsai, M., Walker, J., Yang, G., Sekhon, M., Hillier, L., Zimdahl, H., Marziali, A., Osoegawa, K., Zhao, S., Siddiqui, A., de Jong, P.J., Warren, W., Mardis, E., McPherson, J.D., Wilson, R., Hübner, N., Jones, S., Marra, M. and Schein, J.
Genome Research 14
(4): 766-779.
April 2004
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy.
Janecke, A.R., Thompson, D.A., Utermann, G., Becker, C., Huebner, C.A., Schmid, E., McHenry, C.L., Nair, A.R., Rueschendorf, F., Heckenlively, J., Wissinger, B., Nuernberg, P. and Gal, A.
Nature Genetics 36
(8): 850-854.
1 January 2004
A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H., Nyakatura, G., Brandt, P., Schulz, H., Hummel, O., Fartmann, B., Brett, D., Droege, M., Monti, J., Lee, Y.A., Sun, Y.Y., Zhao, S.Y., Winter, E.E., Ponting, C.P., Chen, Y., Kasprzyk, A., Birney, E., Ganten, D. and Hubner, N.
Science 303
(5659): 807-807.
1 January 2004
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.
Kreutz, R., Hübner, N., James, M.R., Bihoreau, M.T., Gauguier, D., Lathrop, G.M., Ganten, D. and Lindpaintner, K.
Proceedings of the National Academy of Sciences of the United States of America 92
(19): 8778-8782.
12 September 1995
Huppa, Johannes
CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15
: 1383136.
24 June 2024
Hörnberg, Hanna
Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383
(6686): 992-998.
1 March 2024
Ibanez-Tallon, Ines
Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula.
Frahm, S., Slimak, M.A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.F., Tsetlin, V., Maskos, U. and Ibanez-Tallon, I.
Neuron 70
(3): 522-535.
12 May 2011
The molecular and cellular identity of peripheral osmoreceptors.
Lechner, S.G., Markworth, S., Poole, K., Smith, E.S.J., Lapatsina, L., Frahm, S., May, M., Pischke, S., Suzuki, M., Ibanez-Tallon, I., Luft, F.C., Jordan, J. and Lewin, G.R.
Neuron 69
(2): 332-344.
27 January 2011
Silencing neurotransmission with membrane-tethered toxins.
Auer, S., Stuerzebecher, A.S., Juettner, R., Santos-Torres, J., Hanack, C., Frahm, S., Liehl, B. and Ibanez-Tallon, I.
Nature Methods 7
(3): 229-236.
March 2010
The rototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo.
Miwa, J.M., Stevens, T.R., King, S.L., Caldarone, B.J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R.M., Pavlides, C., Lester, H.A., Picciotto, M.R. and Heintz, N.
Neuron 51
(5): 587-600.
7 September 2006
Infante-Duarte, Carmen (ECRC)
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10
(1): 217.
15 January 2019
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Sawcer, S., Hellenthal, G., Pirinen, M., Spencer, C.C., Patsopoulos, N.A., Moutsianas, L., Dilthey, A., Su, Z., Freeman, C., Hunt, S.E., Edkins, S., Gray, E., Booth, D.R., Potter, S.C., Goris, A., Band, G., Oturai, A.B., Strange, A., Saarela, J., Bellenguez, C., Fontaine, B., Gillman, M., Hemmer, B., Gwilliam, R., Zipp, F., Jayakumar, A., Martin, R., Leslie, S., Hawkins, S., Giannoulatou, E., D'alfonso, S., Blackburn, H., Boneschi, F.M., Liddle, J., Harbo, H.F., Perez, M.L., Spurkland, A., Waller, M.J., Mycko, M.P., Ricketts, M., Comabella, M., Hammond, N., Kockum, I., McCann, O.T., Ban, M., Whittaker, P., Kemppinen, A., Weston, P., Hawkins, C., Widaa, S., Zajicek, J., Dronov, S., Robertson, N., Bumpstead, S.J., Barcellos, L.F., Ravindrarajah, R., Abraham, R., Alfredsson, L., Ardlie, K., Aubin, C., Baker, A., Baker, K., Baranzini, S.E., Bergamaschi, L., Bergamaschi, R., Bernstein, A., Berthele, A., Boggild, M., Bradfield, J.P., Brassat, D., Broadley, S.A., Buck, D., Butzkueven, H., Capra, R., Carroll, W.M., Cavalla, P., Celius, E.G., Cepok, S., Chiavacci, R., Clerget-Darpoux, F., Clysters, K., Comi, G., Cossburn, M., Cournu-Rebeix, I., Cox, M.B., Cozen, W., Cree, B.A., Cross, A.H., Cusi, D., Daly, M.J., Davis, E., de Bakker, P.I., Debouverie, M., D'hooghe, M.B., Dixon, K., Dobosi, R., Dubois, B., Ellinghaus, D., Elovaara, I., Esposito, F., Fontenille, C., Foote, S., Franke, A., Galimberti, D., Ghezzi, A., Glessner, J., Gomez, R., Gout, O., Graham, C., Grant, S.F., Guerini, F.R., Hakonarson, H., Hall, P., Hamsten, A., Hartung, H.P., Heard, R.N., Heath, S., Hobart, J., Hoshi, M., Infante-Duarte, C., Ingram, G., Ingram, W., Islam, T., Jagodic, M., Kabesch, M., Kermode, A.G., Kilpatrick, T.J., Kim, C., Klopp, N., Koivisto, K., Larsson, M., Lathrop, M., Lechner-Scott, J.S., Leone, M.A., Leppa, V., Liljedahl, U., Bomfim, I.L., Lincoln, R.R., Link, J., Liu, J., Lorentzen, A.R., Lupoli, S., Macciardi, F., Mack, T., Marriott, M., Martinelli, V., Mason, D., McCauley, J.L., Mentch, F., Mero, I.L., Mihalova, T., Montalban, X., Mottershead, J., Myhr, K.M., Naldi, P., Ollier, W., Page, A., Palotie, A., Pelletier, J., Piccio, L., Pickersgill, T., Piehl, F., Pobywajlo, S., Quach, H.L., Ramsay, P.P., Reunanen, M., Reynolds, R., Rioux, J.D., Rodegher, M., Roesner, S., Rubio, J.P., Ruckert, I.M., Salvetti, M., Salvi, E., Santaniello, A., Schaefer, C.A., Schreiber, S., Schulze, C., Scott, R.J., Sellebjerg, F., Selmaj, K.W., Sexton, D., Shen, L., Simms-Acuna, B., Skidmore, S., Sleiman, P.M., Smestad, C., Sorensen, P.S., Sondergaard, H.B., Stankovich, J., Strange, R.C., Sulonen, A.M., Sundqvist, E., Syvanen, A.C., Taddeo, F., Taylor, B., Blackwell, J.M., Tienari, P., Bramon, E., Tourbah, A., Brown, M.A., Tronczynska, E., Casas, J.P., Tubridy, N., Corvin, A., Vickery, J., Jankowski, J., Villoslada, P., Markus, H.S., Wang, K., Mathew, C.G., Wason, J., Palmer, C.N., Wichmann, H.E., Plomin, R., Willoughby, E., Rautanen, A., Winkelmann, J., Wittig, M., Trembath, R.C., Yaouanq, J., Viswanathan, A.C., Zhang, H., Wood, N.W., Zuvich, R., Deloukas, P., Langford, C., Duncanson, A., Oksenberg, J.R., Pericak-Vance, M.A., Haines, J.L., Olsson, T., Hillert, J., Ivinson, A.J., De Jager, P.L., Peltonen, L., Stewart, G.J., Hafler, D.A., Hauser, S.L., McVean, G., Donnelly, P. and Compston, A.
Nature 476
(7359): 214-219.
10 August 2011
Ivics, Zoltan
Hungary's 'reforms' are threatening basic science.
Izsvak, Z., Ivics, Z. and Mates, L.
Nature 443
(7110): 394.
28 September 2006
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21
(1): 8-11.
1 January 2005
Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z., Stuewe, E.E., Fiedler, D., Katzer, A., Jeggo, P.A. and Ivics, Z.
Molecular Cell 13
(2): 279-290.
1 January 2004
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R., Meuse, L., Chiu, W., Ivics, Z., Izsvak, Z. and Kay, M.A.
Nature Genetics 25
(1): 35-41.
1 May 2000
Izsvak, Zsuzsanna
Non-viral targeted insertion of large payloads into T cells.
Izsvak, Z.
Nature Biomedical Engineering
16 September 2024
(In Press)
Selection on synonymous sites: the unwanted transcript hypothesis.
Radrizzani, S., Kudla, G., Izsvák, Z. and Hurst, L.D.
Nature Reviews Genetics 25
(6): 431-448.
June 2024
Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M., Kondraskhina, A.M., Hurst, L.D. and Izsvák, Z.
Journal of Clinical Investigation 133
(14): e172278.
17 July 2023
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
(10): msac175.
October 2022
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M., Yu, H., Yu, X., Liang, S., Hu, Y., Luo, Y., Izsvák, Z., Sun, C. and Wang, J.
Cell Stem Cell 29
(3): 400-418.e13.
3 March 2022
Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C., Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M.G., Perriello, V.M., Rasko, T., Alberti, G., Magnani, C.F., Cappuzzello, C., Lundberg, F., Pande, A., Dastoli, G., Introna, M., Serafini, M., Biagi, E., Izsvák, Z., Biondi, A. and Tettamanti, S.
Molecular Therapy 28
(9): 1974-1986.
2 September 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T., Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M., Zink, A., Chondrogianni, N., Psomopoulos, F., Prigione, A., Ivics, Z., Pospisilova, S., Skladal, P., Izsvák, Z., Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L., Miskey, C., Zuliani, C., Querques, I., Kapitonov, V., Laukó, A., Fehér, A., Palazzo, A., Diem, T., Lustig, J., Sebe, A., Wang, Y., Dinnyés, A., Izsvák, Z., Barabas, O. and Ivics, Z.
Nucleic Acids Research 48
(1): 316-331.
1 January 2020
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H., Georgakopoulou, A., Psatha, N., Li, C., Capsali, C., Samal, H.B., Anagnostopoulos, A., Ehrhardt, A., Izsvák, Z., Papayannopoulou, T., Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129
(2): 598-615.
1 February 2019
Ten things you should know about transposable elements.
Bourque, G., Burns, K.H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z., Levin, H.L., Macfarlan, T.S., Mager, D.L. and Feschotte, C.
Genome Biology 19
(1): 199.
19 November 2018
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J., Singh, M., Herse, F., Przybyl, L., Haase, N., Golic, M., Yung, H.W., Huppertz, B., Cartwright, J.E., Whitley, G.S., Johnsen, G.M., Levi, G., Isbruch, A., Schulz, H., Luft, F.C., Müller, D.N., Staff, A.C., Hurst, L.D., Dechend, R. and Izsvák, Z.
Circulation 136
(19): 1824-1839.
7 November 2017
Gene therapy with the Sleeping Beauty transposon system.
Kebriaei, P., Izsvák, Z., Narayanavari, S.A., Singh, H. and Ivics, Z.
Trends in Genetics 33
(11): 852-870.
November 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y., Pryputniewicz-Dobrinska, D., Nagy, E.E., Kaufman, C.D., Singh, M., Yant, S., Wang, J., Dalda, A., Kay, M.A., Ivics, Z. and Izsvák, Z.
Nucleic Acids Research 45
(1): 311-326.
9 January 2017
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M., Saydaminova, K., Yumul, R., Krishnan, R., Liu, J., Nagy, E.E., Singh, M., Izsvák, Z., Cattaneo, R., Uckert, W., Palmer, D., Ng, P., Haworth, K.G., Kiem, H.P., Ehrhardt, A., Papayannopoulou, T. and Lieber, A.
Blood 128
(18): 2206-2217.
3 November 2016
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F., Wiedemann, L., Zuliani, C., Querques, I., Sebe, A., Mátés, L., Izsvák, Z., Ivics, Z. and Barabas, O.
Nature Communications 7
: 11126.
30 March 2016
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I., Messing, S.A., Thomas, J., Cosby, R.L., Bilic, I., Miskey, C., Gogol-Döring, A., Kapitonov, V., Diem, T., Dalda, A., Jurka, J., Pritham, E.J., Dyda, F., Izsvák, Z. and Ivics, Z.
Nature Communications 7
: 10716.
2 March 2016
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
(2): 327-346.
February 2016
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S., Fuchs, N.V., Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J.L., Faulkner, G.J. and Schumann, G.G.
Nature Communications 7
: 10286.
8 January 2016
Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C., Rosser, J.M., Newkirk, S.J., Yin, J., Jiang, X., Xing, Z., Whitmore, L., Bashir, S., Ivics, Z., Izsvák, Z., Ye, P., Yu, Y.E. and An, W.
Genome Research 25
(8): 1135-1146.
August 2015
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L., Harris, R.A., Gnerre, S., Veeramah, K.R., Lorente-Galdos, B., Huddleston, J., Meyer, T.J., Herrero, J., Roos, C., Aken, B., Anaclerio, F., Archidiacono, N., Baker, C., Barrell, D., Batzer, M.A., Beal, K., Blancher, A., Bohrson, C.L., Brameier, M., Campbell, M.S., Capozzi, O., Casola, C., Chiatante, G., Cree, A., Damert, A., de Jong, P.J., Dumas, L., Fernandez-Callejo, M., Flicek, P., Fuchs, N.V., Gut, I., Gut, M., Hahn, M.W., Hernandez-Rodriguez, J., Hillier, L.W., Hubley, R., Ianc, B., Izsvák, Z., Jablonski, N.G., Johnstone, L.M., Karimpour-Fard, A., Konkel, M.K., Kostka, D., Lazar, N.H., Lee, S.L., Lewis, L.R., Liu, Y., Locke, D.P., Mallick, S., Mendez, F.L., Muffato, M., Nazareth, L.V., Nevonen, K.A., O'Bleness, M., Ochis, C., Odom, D.T., Pollard, K.S., Quilez, J., Reich, D., Rocchi, M., Schumann, G.G., Searle, S., Sikela, J.M., Skollar, G., Smit, A., Sonmez, K., ten Hallers, B., Terhune, E., Thomas, G.W.C., Ullmer, B., Ventura, M., Walker, J.A., Wall, J.D., Walter, L., Ward, M.C., Wheelan, S.J., Whelan, C.W., White, S., Wilhelm, L.J., Woerner, A.E., Yandell, M., Zhu, B., Hammer, M.F., Marques-Bonet, T., Eichler, E.E., Fulton, L., Fronick, C., Muzny, D.M., Warren, W.C., Worley, K.C., Rogers, J., Wilson, R.K. and Gibbs, R.A.
Nature 513
(7517): 195-201.
11 September 2014
Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D., Waterhouse, P.D., Shelton, D., Shao, Y.W., Watling, C.M., Tang, Q.L., Harris, I.S., Dickson, B.C., Tharmapalan, P., Sandve, G.K., Zhang, X., Bailey, S.D., Berman, H., Wunder, J.S., Izsvák, Z., Lupien, M., Mak, T.W. and Khokha, R.
Nature Genetics 46
(9): 964-972.
September 2014
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Ivics, Z., Izsvak, Z., Medrano, G., Chapman, K.M. and Hamra, F.K.
Nature Protocols 6
(10): 1521-1535.
October 2011
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z., Froehlich, J., Grabundzija, I., Shirley, J.R., Powell, H.M., Chapman, K.M., Ivics, Z. and Hamra, F.K.
Nature Methods 7
(6): 443-445.
June 2010
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y., Liska, F., Gosele, C., Sedova, L., Kren, V., Krenova, D., Ivics, Z., Huebner, N. and Izsvak, Z.
Genome Research 20
(1): 19-27.
January 2010
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Vandendriessche, T., Ivics, Z., Izsvak, Z. and Chuah, M.K.
Blood 114
(8): 1461-1468.
20 August 2009
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X., Huang, X., Nodland, S.E., Mates, L., Ma, L., Izsvak, Z., Ivics, Z., Lebien, T.W., McIvor, R.S., Wagner, J.E. and Zhou, X.
Blood 114
(7): 1319-1330.
13 August 2009
Transposon-mediated genome manipulation in vertebrates.
Ivics, Z., Li, M.A., Mates, L., Boeke, J.D., Nagy, A., Bradley, A. and Izsvak, Z.
Nature Methods 6
(6): 415-422.
June 2009
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L., Chuah, M.K., Belay, E., Jerchow, B., Manoj, N., Acosta-Sanchez, A., Grzela, D.P., Schmitt, A., Becker, K., Matrai, J., Ma, L., Samara-Kuko, E., Gysemans, C., Pryputniewicz, D., Miskey, C., Fletcher, B., Vandendriessche, T., Ivics, Z. and Izsvak, Z.
Nature Genetics 41
(6): 753-761.
June 2009
Progress and prospects in rat genetics: a community view.
Aitman, T.J., Critser, J.K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X.M., Flint, J., Gauguier, D., Geurts, A.M., Gould, M., Harris, P.C., Holmdahl, R., Huebner, N., Izsvak, Z., Jacob, H.J., Kuramoto, T., Kwitek, A.E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J.D., Szpirer, C., Twigger, S.N., Voigt, B. and Worley, K.C.
Nature Genetics 40
(5): 516-22.
May 2008
Hungary's 'reforms' are threatening basic science.
Izsvak, Z., Ivics, Z. and Mates, L.
Nature 443
(7110): 394.
28 September 2006
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21
(1): 8-11.
1 January 2005
Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z., Stuewe, E.E., Fiedler, D., Katzer, A., Jeggo, P.A. and Ivics, Z.
Molecular Cell 13
(2): 279-290.
1 January 2004
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R., Meuse, L., Chiu, W., Ivics, Z., Izsvak, Z. and Kay, M.A.
Nature Genetics 25
(1): 35-41.
1 May 2000
Janz, Martin / Mathas, Stephan (MDC/ECRC)
Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial.
Borchmann, P., Ferdinandus, J., Schneider, G., Moccia, A., Greil, R., Hertzberg, M., Schaub, V., Hüttmann, A., Keil, F., Dierlamm, J., Hänel, M., Novak, U., Meissner, J., Zimmermann, A., Mathas, S., Zijlstra, J.M., Fosså, A., Viardot, A., Hertenstein, B., Martin, S., Giri, P., Scholl, S., Topp, M.S., Jung, W., Vucinic, V., Beck, H.J., Kerkhoff, A., Unger, B., Rank, A., Schroers, R., zum Büschenfelde, C.M., de Wit, M., Trautmann-Grill, K., Kamper, P., Molin, D., Kreissl, S., Kaul, H., von Tresckow, B., Borchmann, S., Behringer, K., Fuchs, M., Rosenwald, A., Klapper, W., Eich, H.T., Baues, C., Zomas, A., Hallek, M., Dietlein, M., Kobe, C. and Diehl, V.
Lancet 404
(10450): 341-352.
27 July 2024
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression.
Redmer, T., Raigel, M., Sternberg, C., Ziegler, R., Probst, C., Lindner, D., Aufinger, A., Limberger, T., Trachtova, K., Kodajova, P., Högler, S., Schlederer, M., Stoiber, S., Oberhuber, M., Bolis, M., Neubauer, H.A., Miranda, S., Tomberger, M., Harbusch, N.S., Garces de Los Fayos Alonso, I., Sternberg, F., Moriggl, R., Theurillat, J.P., Tichy, B., Bystry, V., Persson, J.L., Mathas, S., Aberger, F., Strobl, B., Pospisilova, S., Merkel, O., Egger, G., Lagger, S. and Kenner, L.
Molecular Cancer 23
(1): 114.
29 May 2024
Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced stage Hodgkin Lymphoma: results from the randomized international GHSG HD18 trial.
Ferdinandus, J., Müller, H., Damaschin, C., Jacob, A.S., Meissner, J., Krasniqi, F., Mey, U., Schöndube, D., Thiemer, J., Mathas, S., Zijlstra, J., Greil, R., Feuring-Buske, M., Markova, J., Rüffer, J.U., Kobe, C., Eich, H.T., Baues, C., Fuchs, M., Borchmann, P. and Behringer, K.
Annals of Oncology 35
(3): 276-284.
March 2024
High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial.
Schorb, E., Isbell, L.K., Kerkhoff, A., Mathas, S., Braulke, F., Egerer, G., Röth, A., Schliffke, S., Borchmann, P., Brunnberg, U., Kroschinsky, F., Möhle, R., Rank, A., Wellnitz, D., Kasenda, B., Pospiech, L., Wendler, J., Scherer, F., Deckert, M., Henkes, E., von Gottberg, P., Gmehlin, D., Backenstraß, M., Jensch, A., Burger-Martin, E., Grishina, O., Fricker, H., Malenica, N., Orbán, A., Duyster, J., Ihorst, G., Finke, J. and Illerhaus, G.
Lancet Haematology 11
(3): e196-e205.
March 2024
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14
(1): 6947.
7 November 2023
The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomas.
Kouroukli, A.G., Fischer, A., Kretzmer, H., Chteinberg, E., Rajaram, N., Glaser, S., Kolarova, J., Bashtrykov, P., Mathas, S., Drexler, H.G., Ohno, H., Ammerpohl, O., Jeltsch, A., Siebert, R. and Bens, S.
Blood Cancer Journal 13
(1): 98.
26 June 2023
Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.
Bonifacius, A., Lamottke, B., Tischer-Zimmermann, S., Schultze-Florey, R., Goudeva, L., Heuft, H.G., Arseniev, L., Beier, R., Beutel, G., Cario, G., Fröhlich, B., Greil, J., Hansmann, L., Hasenkamp, J., Höfs, M., Hundsdoerfer, P., Jost, E., Kafa, K., Kriege, O., Kröger, N., Mathas, S., Meisel, R., Nathrath, M., Putkonen, M., Ravens, S., Reinhardt, H.C., Sala, E., Sauer, M.G, Schmitt, C., Schroers, R., Steckel, N.K., Trappe, R.U., Verbeek, M., Wolff, D., Blasczyk, R., Eiz-Vesper, B. and Maecker-Kolhoff, B.
Journal of Clinical Investigation 133
(12): e163548.
15 June 2023
Nivolumab and doxorubicin, vinblastine, and dacarbazine in early-stage unfavorable Hodgkin Lymphoma: final analysis of the randomized german Hodgkin study group phase II NIVAHL trial.
Bröckelmann, P.J., Bühnen, I., Meissner, J., Trautmann-Grill, K., Herhaus, P., Halbsguth, T.V., Schaub, V., Kerkhoff, A., Mathas, S., Bormann, M., Dickhut, A., Kaul, H., Fuchs, M., Kobe, C., Baues, C., Borchmann, P., Engert, A. and von Tresckow, B.
Journal of Clinical Oncology 41
(6): 1193-1199.
20 February 2023
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N., Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A., André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M., Cui, C., Daumke, O., Del Bel, K.L., Eibel, H., Feng, X., Franke, V., Gebhardt, J.C.M., Götz, A., Grunwald, S., Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M., Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W., Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S., Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8
(79): eade7953.
January 2023
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso, I., Zujo, L., Wiest, I., Kodajova, P., Timelthaler, G., Edtmayer, S., Zrimšek, M., Kollmann, S., Giordano, C., Kothmayer, M., Neubauer, H.A., Dey, S., Schlederer, M., Schmalzbauer, B.S., Limberger, T., Probst, C., Pusch, O., Högler, S., Tangermann, S., Merkel, O., Schiefer, A.I., Kornauth, C., Prutsch, N., Zimmerman, M., Abraham, B., Anagnostopoulos, J., Quintanilla-Martinez, L., Mathas, S., Wolf, P., Stoiber, D., Staber, P.B., Egger, G., Klapper, W., Woessmann, W., Look, T.A., Gunning, P., Turner, S.D., Moriggl, R., Lagger, S. and Kenner, L.
Molecular Cancer 21
(1): 172.
31 August 2022
Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
Bishop, M.R., Dickinson, M., Purtill, D., Barba, P., Santoro, A., Hamad, N., Kato, K., Sureda, A., Greil, R., Thieblemont, C., Morschhauser, F., Janz, M., Flinn, I., Rabitsch, W., Kwong, Y.L., Kersten, M.J, Minnema, M.C., Holte, H., Chan, E.H.L., Martinez-Lopez, J., Müller, A.M.S., Maziarz, R.T., McGuirk, J.P., Bachy, E., Le Gouill, S., Dreyling, M., Harigae, H., Bond, D., Andreadis, C., McSweeney, P., Kharfan-Dabaja, M., Newsome, S., Degtyarev, E., Awasthi, R., Del Corral, C., Andreola, G., Masood, A., Schuster, S.J., Jäger, U., Borchmann, P. and Westin, J.R.
New England Journal of Medicine 386
(7): 629-639.
17 February 2022
Brentuximab vedotin-containing escalated BEACOPP variants for newly diagnosed advanced-stage classical Hodgkin lymphoma: follow-up analysis of a randomized phase II study from the German Hodgkin Study Group.
Damaschin, C., Goergen, H., Kreissl, S., Plütschow, A., Breywisch, F., Mathas, S., Meissner, J., Sökler, M., Topp, M.S., Vucinic, V., Zimmermann, A., von Tresckow, B., Fuchs, M., Engert, A., Borchmann, P. and Eichenauer, D.A.
Leukemia 36
(2): 580-582.
February 2022
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Liang, H.C., Costanza, M., Prutsch, N., Zimmerman, M.W., Gurnhofer, E., Montes-Mojarro, I.A., Abraham, B.J., Prokoph, N., Stoiber, S., Tangermann, S., Lobello, C., Oppelt, J., Anagnostopoulos, I., Hielscher, T., Pervez, S., Klapper, W., Zammarchi, F., Silva, D.A., Garcia, K.C., Baker, D., Janz, M., Schleussner, N., Fend, F., Pospíšilová, Š., Janiková, A., Wallwitz, J., Stoiber, D., Simonitsch-Klupp, I., Cerroni, L., Pileri, S., de Leval, L., Sibon, D., Fataccioli, V., Gaulard, P., Assaf, C., Knörr, F., Damm-Welk, C., Woessmann, W., Turner, S.D., Look, A.T., Mathas, S., Kenner, L. and Merkel, O.
Nature Communications 12
(1): 5577.
22 September 2021
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S., Bröckelmann, P.J., Iaccarino, I., Garcia-Marquez, M., Borchmann, S., Jochims, F., Kotrova, M., Pal, K., Brüggemann, M., Hartmann, E., Sasse, S., Kobe, C., Mathas, S., Soekler, M., Keller, U., Bormann, M., Zimmermann, A., Richter, J., Fuchs, M., von Tresckow, B., Borchmann, P., Schlößer, H., von Bergwelt-Baildon, M., Rosenwald, A., Engert, A. and Klapper, W.
Blood 136
(25): 2851-2863.
17 December 2020
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
Restriction of memory B cell differentiation at the germinal center B cell positive selection stage.
Toboso-Navasa, A., Gunawan, A., Morlino, G., Nakagawa, R., Taddei, A., Damry, D., Patel, Y., Chakravarty, P., Janz, M., Kassiotis, G., Brink, R., Eilers, M. and Calado, D.P.
Journal of Experimental Medicine 217
(7): e20191933.
6 July 2020
Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J., Goergen, H., Keller, U., Meissner, J., Ordemann, R., Halbsguth, T.V., Sasse, S., Sökler, M., Kerkhoff, A., Mathas, S., Hüttmann, A., Bormann, M., Zimmermann, A., Mettler, J., Fuchs, M., von Tresckow, B., Baues, C., Rosenwald, A., Klapper, W., Kobe, C., Borchmann, P. and Engert, A.
JAMA Oncology 6
(6): 872-880.
June 2020
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group.
Eichenauer, D.A., Plütschow, A., Kreissl, S., Sökler, M., Hellmuth, J.C., Meissner, J., Mathas, S., Topp, M.S., Behringer, K., Klapper, W., Kuhnert, G., Dietlein, M., Kobe, C., Fuchs, M., Diehl, V., Engert, A. and Borchmann, P.
Lancet Oncology 18
(12): 1680-1687.
December 2017
Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D., Hummel, F., Richter, J., Giefing, M., Hartmann, S., Hansmann, M.L., Kreher, S., Köchert, K., Krappmann, D., Klapper, W., Hummel, M., Wenzel, S.S., Lenz, G., Janz, M., Dörken, B., Siebert, R. and Mathas, S.
Leukemia 31
(3): 602-613.
March 2017
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J., Neuenschwander, M., Yu, Y., Däbritz, J.H.M., Neuendorff, N.R., Schleich, K., Bittner, A., Milanovic, M., Beuster, G., Radetzki, S., Specker, E., Reimann, M., Rosenbauer, F., Mathas, S., Lohneis, P., Hummel, M., Dörken, B., von Kries, J.P., Lee, S. and Schmitt, C.A.
Blood 129
(1): 71-81.
5 January 2017
The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.
Ullrich, K., Blumenthal-Barby, F., Lamprecht, B., Koechert, K., Lenze, D., Hummel, M., Mathas, S., Doerken, B. and Janz, M.
Leukemia 29
(5): 1213-1218.
May 2015
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A., Grau, M., Erdmann, T., Merkel, O., Sobhiafshar, U., Anagnostopoulos, I., Hummel, M., Siegert, A., Hayford, C., Madle, H., Wollert-Wulf, B., Fichtner, I., Dörken, B., Dirnhofer, S., Mathas, S., Janz, M., Emre, N.C.T., Rosenwald, A., Ott, G., Lenz, P., Tzankov, A. and Lenz, G.
Blood 125
(1): 124-132.
1 January 2015
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P., Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K., Sleckman, B.P., de Alboran, I.M., Janz, M., Rodig, S. and Rajewsky, K.
Nature Immunology 13
(11): 1092-1100.
November 2012
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger, A., Moebs, M., Ullmann, R., Koechert, K., Kreher, S., Lamprecht, B., Anagnostopoulos, I., Hummel, M., Richter, J., Beyer, M., Janz, M., Klemke, C.D., Stein, H., Doerken, B., Sterry, W., Schrock, E., Mathas, S. and Assaf, C.
Journal of Experimental Medicine 208
(8): 1585-1593.
1 August 2011
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Koechert, K., Bouhlel, M.A., Richter, J., Soler, E., Stadhouders, R., Joehrens, K., Wurster, K.D., Callen, D.F., Harte, M.F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., Cockerill, P.N., Siebert, R., Doerken, B., Bonifer, C. and Mathas, S.
Nature Medicine 16
(5): 571-579, 1p following 579.
May 2010
The dangers of transcription.
Mathas, S. and Misteli, T.
Cell 139
(6): 1047-1049.
11 December 2009
C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R., Janz, M., Galson, D.L., Gries, M., Li, S., Johrens, K., Anagnostopoulos, I., Doerken, B., Mapara, M.Y., Borghesi, L., Kardava, L., Roodman, G.D., Milcarek, C. and Lentzsch, S.
Blood 114
(18): 3890-3898.
29 October 2009
Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B., Kreher, S., Anagnostopoulos, I., Joehrens, K., Monteleone, G., Jundt, F., Stein, H., Janz, M., Doerken, B. and Mathas, S.
Blood 112
(8): 3339-3347.
15 October 2008
Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma.
Martin-Subero, J.I., Wlodarska, I., Bastard, C., Picquenot, J.M., Hoeppner, J., Giefing, M., Klapper, W., Siebert, R., Mathas, S., Joos, S., Stein, H. and Doerken, B.
Blood 108
: 401-403.
1 July 2006
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells.
Janz, M., Hummel, M., Truss, M., Wollert-Wulf, B., Mathas, S., Joehrens, K., Hagemeier, C., Bommert, K., Stein, H., Doerken, B. and Bargou, R.C.
Blood 107
(6): 2536-2539.
15 March 2006
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7
(2): 207-215.
February 2006
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S., Joehrens, K., Joos, S., Lietz, A., Hummel, F., Janz, M., Jundt, F., Anagnostopoulos, I., Bommert, K., Lichter, P., Stein, H., Scheidereit, C. and Doerken, B.
Blood 106
(13): 4287-4293.
25 August 2005
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F., Raetzel, N., Mueller, C., Calkhoven, C.F., Kley, K., Mathas, S., Lietz, A., Leutz, A. and Doerken, B.
Blood 106
: 1801-1807.
1 January 2005
Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R., Janz, M., Mapara, M.Y., Lemke, B., Stirling, D., Doerken, B., Zenke, M. and Lentzsch, S.
Blood 105
(10): 3833-3840.
1 January 2005
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.
Mathas, S., Lietz, A., Anagnostopoulos, I., Hummel, F., Wiesner, B., Janz, M., Jundt, F., Hirsch, B., Joehrens-Leder, K., Vornlocher, H.P., Bommert, K., Stein, H. and Doerken, B.
Journal of Experimental Medicine 199
(8): 1041-1052.
19 April 2004
Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S., Lietz, A., Janz, M., Hinz, M., Jundt, F., Scheidereit, C., Bommert, K. and Doerken, B.
Blood 102
(3): 1028-1034.
1 August 2003
Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S., Gries, M., Janz, M., Bargou, R., Doerken, B. and Mapara, M.Y.
Blood 101
(9): 3568-3573.
1 May 2003
Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196
(5): 605-617.
2 September 2002
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S., Hinz, M., Anagnostopoulos, L., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dörken, B. and Scheidereit, C.
EMBO Journal 21
(15): 4104-4113.
1 August 2002
Jentsch, Thomas
Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B., Zhang, S., Polovitskaya, M.M., Yi, J., Ye, B., Li, R., Huang, X., Yin, J., Neuens, S., Balfroid, T., Soblet, J., Vens, D., Aeby, A., Li, X., Cai, J., Song, Y., Li, Y., Tartaglia, M., Li, Y., Jentsch, T.J., Yang, M. and Liu, Z.
Science Advances 9
(41): eadg4479.
13 October 2023
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Campos, J., Mayer, C., D Este, E., Möbius, W., Cordano, C., Pröbstel, A.K., Gharagozloo, M., Zulji, A., Narayanan Naik, V., Delank, A.K., Cerina, M., Müntefering, T., Lerma-Martin, C., Sonner, J.K., Sin, J.H., Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K.C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T.J., Engelhardt, M., Budde, T., Nave, K.A., Calabresi, P.A., Friese, M.A., Green, A.J., Acuna, C., Rowitch, D.H., Meuth, S.G. and Schirmer, L.
Journal of Clinical Investigation 133
(7): e164223.
3 April 2023
SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A., López-Cayuqueo, K.I., Scherer, N., Wuttke, M., Wernstedt, A., González Fassrainer, D., Smith, D.E., van de Kamp, J.M., Ziegeler, K., Eckardt, K.U., Luft, F.C., Aronson, P.S., Köttgen, A., Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133
(3): e161849.
1 February 2023
Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 33
(8): 1528-1545.
August 2022
Proton-gated anion transport governs macropinosome shrinkage.
Zeziulia, M., Blin, S., Schmitt, F.W., Lehmann, M. and Jentsch, T.J.
Nature Cell Biology 24
(6): 885-895.
June 2022
Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C., Polovitskaya, M.M., Delgado, B.D., Jentsch, T.J. and Long, S.B.
Science Advances 8
(5): eabm3942.
2 February 2022
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.A., Carus-Cadavieco, M., Korotkova, T., Tzingounis, A.V., Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12
(1): 4801.
10 August 2021
Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Duncan, A.R., Polovitskaya, M.M., Gaitán-Peñas, H., Bertelli, S., VanNoy, G.E., Grant, P.E., O'Donnell-Luria, A., Valivullah, Z., Lovgren, A.K., England, E.M., Agolini, E., Madden, J.A., Schmitz-Abe, K., Kritzer, A., Hawley, P., Novelli, A., Alfieri, P., Colafati, G.S., Wieczorek, D., Platzer, K., Luppe, J., Koch-Hogrebe, M., Abou Jamra, R., Neira-Fresneda, J., Lehman, A., Boerkoel, C.F., Seath, K., Clarke, L., van Ierland, Y., Argilli, E., Sherr, E.H., Maiorana, A., Diel, T., Hempel, M., Bierhals, T., Estévez, R., Jentsch, T.J., Pusch, M. and Agrawal, P.B.
American Journal of Human Genetics 108
(8): 1450-1465.
5 August 2021
A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration.
Polovitskaya, M.M., Barbini, C., Martinelli, D., Harms, F.L., Cole, F.S., Calligari, P., Bocchinfuso, G., Stella, L., Ciolfi, A., Niceta, M., Rizza, T., Shinawi, M., Sisco, K., Johannsen, J., Denecke, J., Carrozzo, R., Wegner, D.J., Kutsche, K., Tartaglia, M. and Jentsch, T.J.
American Journal of Human Genetics 107
(6): 1062-1077.
3 December 2020
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C., Chen, X., Planells-Cases, R., Chu, J., Wang, L., Cao, L., Li, Z., López-Cayuqueo, K.I., Xie, Y., Ye, S., Wang, X., Ullrich, F., Ma, S., Fang, Y., Zhang, X., Qian, Z., Liang, X., Cai, S.Q., Jiang, Z., Zhou, D., Leng, Q., Xiao, T.S., Lan, K., Yang, Ji., Li, H., Peng, C., Qiu, Z., Jentsch, T.J. and Xiao, H.
Immunity 52
(5): 767-781.
19 May 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S., Gimber, N., Deuschel, D., Stuhlmann, T., Puchkov, D., Farsi, Z., Ludwig, C.F., Novarino, G., López-Cayuqueo, K.I., Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39
(9): e103358.
4 May 2020
Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C., Orozco, I.J., Hoegg-Beiler, M.B., Soria, A.H., Hübner, C.A., Fernandes-Rosa, F.L., Boulkroun, S., Zennaro, M.C. and Jentsch, T.J.
Nature Communications 10
(1): 4678.
15 October 2019
CLC chloride channels and transporters: structure, function, physiology, and disease.
Jentsch, T.J. and Pusch, M.
Physiological Reviews 98
(3): 1493-1590.
July 2018
LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T., Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9
(1): 1974.
17 May 2018
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Fernandes-Rosa, F.L., Daniil, G., Orozco, I.J., Göppner, C., El Zein, R., Jain, V., Boulkroun, S., Jeunemaitre, X., Amar, L., Lefebvre, H., Schwarzmayr, T., Strom, T.M., Jentsch, T.J. and Zennaro, M.C.
Nature Genetics 50
(3): 355-361.
March 2018
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer, E.E., Stuhlmann, T., Weinert, S., Haan, E., Van Esch, H., Holvoet, M., Boyle, J., Leffler, M., Raynaud, M., Moraine, C., van Bokhoven, H., Kleefstra, T., Kahrizi, K., Najmabadi, H., Ropers, H.H., Delgado, M.R., Sirsi, D., Golla, S., Sommer, A., Pietryga, M.P., Chung, W.K., Wynn, J., Rohena, L., Bernardo, E., Hamlin, D., Faux, B.M., Grange, D.K., Manwaring, L., Tolmie, J., Joss, S., Cobben, J.M., Duijkers, F.A.M., Goehringer, J.M., Challman, T.D., Hennig, F., Fischer, U., Grimme, A., Suckow, V., Musante, L., Nicholl, J., Shaw, M., Lodh, S.P., Niu, Z., Rosenfeld, J.A., Stankiewicz, P., Jentsch, T.J., Gecz, J., Field, M. and Kalscheuer, V.M.
Molecular Psychiatry 23
(2): 222-230.
February 2018
Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing, S., Rudnik, S., Damme, M., Luellmann-Rauch, R., Ichihara, A., Kornak, U., Eskelinen, E.L., Jabs, S., Heeren, J., De Brabander, J.K., Haas, A. and Saftig, P.
Autophagy 13
(4): 670-685.
April 2017
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Gödde, K., Gschwend, O., Puchkov, D., Pfeffer, C.K., Carleton, A. and Jentsch, T.J.
Nature Communications 7
: 12043.
8 July 2016
VRACs and other ion channels and transporters in the regulation of cell volume and beyond.
Jentsch, T.J.
Nature Reviews Molecular Cell Biology 17
(5): 293-307.
May 2016
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H., Haas, S.A., Chelly, J., Van Esch, H., Raynaud, M., de Brouwer, A.P.M., Weinert, S., Froyen, G., Frints, S.G.M., Laumonnier, F., Zemojtel, T., Love, M.I., Richard, H., Emde, A.K., Bienek, M., Jensen, C., Hambrock, M., Fischer, U., Langnick, C., Feldkamp, M., Wissink-Lindhout, W., Lebrun, N., Castelnau, L., Rucci, J., Montjean, R., Dorseuil, O., Billuart, P., Stuhlmann, T., Shaw, M., Corbett, M.A., Gardner, A., Willis-Owen, S., Tan, C., Friend, K.L., Belet, S., van Roozendaal, K.E.P., Jimenez-Pocquet, M., Moizard, M.P., Ronce, N., Sun, R., O'Keeffe, S., Chenna, R., van Bömmel, A., Goeke, J., Hackett, A., Field, M., Christie, L., Boyle, J., Haan, E., Nelson, J., Turner, G., Baynam, G., Gillessen-Kaesbach, G., Mueller, U., Steinberger, D., Budny, B., Badura-Stronka, M., Latos-Bieleńska, A., Ousager, L.B., Wieacker, P., Rodríguez Criado, G., Bondeson, M.L., Annerén, G., Dufke, A., Cohen, M., Van Maldergem, L., Vincent-Delorme, C., Echenne, B., Simon-Bouy, B., Kleefstra, T., Willemsen, M., Fryns, J.P., Devriendt, K., Ullmann, R., Vingron, M., Wrogemann, K., Wienker, T.F., Tzschach, A., van Bokhoven, H., Gecz, J., Jentsch, T.J., Chen, W., Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21
(1): 133-148.
January 2016
Optogenetic acidification of synaptic vesicles and lysosomes.
Rost, B.R., Schneider, F., Grauel, M.K., Wozny, C., Bentz, C.G., Blessing, A., Rosenmund, T., Jentsch, T.J., Schmitz, D., Hegemann, P. and Rosenmund, C.
Nature Neuroscience 18
(12): 1845-1852.
December 2015
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P., Korotkova, T., Heidenreich, M., Maier, N., Schuetze, S., Kobler, O., Zuschratter, W., Schmitz, D., Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6
: 6254.
4 February 2015
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J., Kassmann, M., Szijártó, I.A., Hercule, H.C., Tano, J.Y., Weinert, S., Heidenreich, M., Pathan, A.R., Anistan, Y.M., Alenina, N., Rusch, N.J., Bader, M., Jentsch, T.J. and Gollasch, M.
Circulation Research 115
(2): 263-272.
7 July 2014
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K., Ullrich, F., Muench, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M.A., von Kries, J.P., Stauber, T. and Jentsch, T.J.
Science 344
(6184): 634-638.
9 May 2014
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Hoegg-Beiler, M.B., Sirisi, S., Orozco, I.J., Ferrer, I., Hohensee, S., Auberson, M., Goedde, K., Vilches, C., de Heredia, M.L., Nunes, V., Estévez, R. and Jentsch, T.J.
Nature Communications 5
: 3475.
19 March 2014
From mice to man: chloride transport in leukoencephalopathy.
Jentsch, T.J.
Lancet Neurology 12
(7): 626-628.
July 2013
Chloride in vesicular trafficking and function.
Stauber, T. and Jentsch, T.J.
Annual Review of Physiology 75
: 453-477.
10 February 2013
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Jeworutzki, E., Lopez-Hernandez, T., Capdevila-Nortes, X., Sirisi, S., Bengtsson, L., Montolio, M., Zifarelli, G., Arnedo, T., Mueller, C.S., Schulte, U., Nunes, V., Martinez, A., Jentsch, T.J., Gasull, X., Pusch, M. and Estevez, R.
Neuron 73
(5): 951-961.
8 March 2012
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Heidenreich, M., Lechner, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aranguez, G., Moreno-Pelayo, M.A., Jentsch, T.J. and Lewin, G.R.
Nature Neuroscience 15
(1): 138-145.
2012
Ca(2+)-activated Cl(-) currents are dispensable for olfaction.
Billig, G.M., Pal, B., Fidzinski, P. and Jentsch, T.J.
Nature Neuroscience 14
(6): 763-769.
June 2011
ClC-3-A granular anion transporter involved in insulin secretion?
Jentsch, T.J., Maritzen, T., Keating, D.J., Zdebik, A.A. and Thevenod, F.
Cell Metabolism 12
(4): 307-308.
6 October 2010
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G., Weinert, S., Rickheit, G. and Jentsch, T.J.
Science 328
(5984): 1398-1401.
11 June 2010
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S., Jabs, S., Supanchart, C., Schweizer, M., Gimber, N., Richter, M., Rademann, J., Stauber, T., Kornak, U. and Jentsch, T.J.
Science 328
(5984): 1401-1403.
11 June 2010
No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.
Niemeyer, M.I., Cid, L.P., Sepulveda, F.V., Blanz, J., Auberson, M. and Jentsch, T.J.
Nature Genetics 42
(1): 3.
January 2010
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rust, M.B., Alper, S.L., Rudhard, Y., Shmukler, B.E., Vicente, R., Brugnara, C., Trudel, M., Jentsch, T.J. and Huebner, C.A.
Journal of Clinical Investigation 117
(6): 1708-1717.
1 June 2007
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C., Schoser, B.G.H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.A., Nothen, M.M., Wienker, T.F., Malin, J.P., Propping, P., Reis, A., Mortier, W., Jentsch, T.J., Vorgerd, M. and Kubisch, C.
Nature Genetics 28
(3): 218-219.
July 2001
Jordan, Jens
Plasma exchange for primary autoimmune autonomic failure.
Schroeder, C., Vernino, S., Birkenfeld, A.L., Tank, J., Heusser, K., Lipp, A., Benter, T., Lindschau, C., Kettritz, R., Luft, F.C. and Jordan, J.
New England Journal of Medicine 353
(15): 1585-1590.
13 October 2005
Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.
Christou, D.D., Jones, P.P., Jordan, J., Diedrich, A., Robertson, D. and Seals, D.R.
Circulation 111
: 494-498.
1 February 2005
Water potentiates the pressor effect of ephedra alkaloids.
Jordan, J., Shannon, J.R., Diedrich, A., Black, B., Robertson, D. and Biaggioni, I.
Circulation 109
(15): 1823-1825.
20 April 2004
Water ingestion as prophylaxis against syncope.
Lu, C.C., Diedrich, A., Tung, C.S., Paranjape, S.Y., Harris, P.A., Byrne, D.W., Jordan, J. and Robertson, D.
Circulation 108
(21): 2660-2665.
25 November 2003
Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition.
Tank, J., Schroeder, C., Diedrich, A., Szczech, E., Haertter, S., Sharma, A.M., Luft, F.C. and Jordan, J.
Circulation 107
(23): 2949-2954.
17 June 2003
Baroreflex buffering is reduced with age in healthy men.
Jones, P.P., Christou, D.D., Jordan, J. and Seals, D.R.
Circulation 107
(13): 1770-1774.
8 April 2003
Potential for sibutramine-yohimbine interaction? (correspondence).
Jordan, J. and Sharma, A.M.
Lancet 361
: 1826.
1 January 2003
Water drinking acutely improves orthostatic tolerance in healthy subjects.
Schroeder, C., Bush, V.E., Norcliffe, L.J., Luft, F.C., Tank, J., Jordan, J. and Hainsworth, R.
Circulation 106
(22): 2806-2811.
26 November 2002
Paradoxical effect of sibutramine on autonomic cardiovascular regulation.
Birkenfeld, A.L., Schroeder, C., Boschmann, M., Tank, J., Franke, G., Luft, F.C., Biaggioni, I., Sharma, A.M. and Jordan, J.
Circulation 106
(19): 2459-2465.
5 November 2002
Modulation of QT interval during autonomic nervous system blockade in humans.
Diedrich, A., Jordan, J., Shannon, J.R., Robertson, D. and Biaggioni, I.
Circulation 106
(17): 2238-2243.
22 October 2002
Catechol-O-methyltransferase and blood pressure in humans.
Jordan, J., Lipp, A., Tank, J., Schroeder, C., Stoffels, M., Franke, G., Diedrich, A., Arnold, G., Goldstein, D.S., Sharma, A.M. and Luft, F.C.
Circulation 106
(4): 460-465.
23 July 2002
Baroreflex buffering and susceptibility to vasoactive drugs.
Jordan, J., Tank, J., Shannon, J.R., Diedrich, A., Lipp, A., Schroeder, C., Arnold, G., Sharma, A.M., Biaggioni, I., Robertson, D. and Luft, F.C.
Circulation 105
(12): 1459-1464.
26 March 2002
Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance.
Schroeder, C., Tank, J., Boschmann, M., Diedrich, A., Sharma, A.M., Biaggioni, I., Luft, F.C. and Jordan, J.
Circulation 105
(3): 347-353.
22 January 2002
Altered autonomic support of arterial blood pressure with age in healthy men.
Jones, P.P., Shapiro, L.F., Keisling, G.A., Jordan, J., Shannon, J.R., Quaife, R.A. and Seals, D.R.
Circulation 104
: 2424-2429.
1 January 2001
Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact.
Jordan, J., Toka, H.R., Heusser, K., Toka, O., Shannon, J.R., Tank, J., Diedrich, A., Stabroth, C., Stoffels, M., Naraghi, R., Oelkers, W., Schuster, H., Schobel, H.P., Haller, H. and Luft, F.C.
Circulation 102
: 2611-2618.
21 November 2000
Traumatic ventricular aneurysm.
Jordan, J. and Dietz, R.
New England Journal of Medicine 336
(9): 625-625.
27 February 1997
Junker, Jan Philipp (BIMSB)
Mapping lineage-traced cells across time points with moslin.
Lange, M., Piran, Z., Klein, M., Spanjaard, B., Klein, D., Junker, J.P., Theis, F.J. and Nitzan, M.
Genome Biology 25
(1): 277.
21 October 2024
Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish.
Cardeira-da-Silva, J., Wang, Q., Sagvekar, P., Mintcheva, J., Latting, S., Günther, S., Ramadass, R., Yekelchyk, M., Preussner, J., Looso, M., Junker, J.P. and Stainier, D.Y.R.
Nature Communications 15
(1): 3637.
29 April 2024
Transcription factor induction of vascular blood stem cell niches in vivo.
Hagedorn, E.J., Perlin, J.R., Freeman, R.J., Wattrus, S.J., Han, T., Mao, C., Kim, J.W., Fernández-Maestre, I., Daily, M.L., D'Amato, C., Fairchild, M.J., Riquelme, R., Li, B., Ragoonanan, D.A.V.E., Enkhbayar, K., Henault, E.L., Wang, H.G., Redfield, S.E., Collins, S.H., Lichtig, A., Yang, S., Zhou, Y., Kunar, B., Gomez-Salinero, J.M., Dinh, T.T., Pan, J., Holler, K., Feldman, H.A., Butcher, E.C., van Oudenaarden, A., Rafii, S., Junker, J.P. and Zon, L.I.
Developmental Cell 58
(12): 1037-1051.
19 June 2023
Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
Boogerd, C.J., Lacraz, G.P.A., Vértesy, Á., van Kampen, S.J., Perini, I., de Ruiter, H., Versteeg, D., Brodehl, A., van der Kraak, P., Giacca, M., de Jonge, N., Junker, J.P., van Oudenaarden, A., Vink, A. and van Rooij, E.
Cardiovascular Research 119
(2): 477-491.
February 2023
Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C., Maghsudi, S. and Ohler, U.
Nucleic Acids Research 50
(18): e107.
14 October 2022
Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D. and Junker, J.P.
Nature Genetics 54
(8): 1227-1237.
August 2022
Transient activated fibroblasts contribute to zebrafish heart regeneration.
Junker, J.P. and Panáková, D.
Nature Genetics 54
(8): 1076-1077.
August 2022
Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M. and Junker, J.P.
Nature Communications 12
: 3358.
7 June 2021
Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49
(8): 4325-4337.
7 May 2021
The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D., Formichetti, S., Junker, J.P., Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16
(11): e9946.
1 November 2020
GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli, G., Custodio, J., Kallas, T., Agostini, F., Wernersson, E., Spanjaard, B., Mota, A., Kolbeinsdottir, S., Gelali, E., Crosetto, N. and Bienko, M.
Nature Biotechnology 38
(10): 1184-1193.
October 2020
Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.
Yvernogeau, L., Klaus, A., Maas, J., Morin-Poulard, I., Weijts, B., Schulte-Merker, S., Berezikov, E., Junker, J.P. and Robin, C.
Blood 136
(7): 831-844.
13 August 2020
Detouring the roadblocks in gene expression.
Junker, J.P.
Nature Reviews Molecular Cell Biology 20
(4): 197.
April 2019
Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars.
Spanjaard, B., Hu, B., Mitic, N., Olivares-Chauvet, P., Janjuha, S., Ninov, N. and Junker, J.P.
Nature Biotechnology 36
(5): 469-473.
May 2018
Methods for lineage tracing on the organism-wide level.
Spanjaard, B. and Junker, J.P.
Current Opinion in Cell Biology 49
: 16-21.
December 2017
Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.
Lacraz, G.P.A., Junker, J.P., Gladka, M.M., Molenaar, B., Scholman, K.T., Vigil-Garcia, M., Versteeg, D., de Ruiter, H., Vermunt, M.W., Creyghton, M.P., Huibers, M.M.H., de Jonge, N., van Oudenaarden, A. and van Rooij, E.
Circulation 136
(15): 1396-1409.
10 October 2017
Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations.
van den Brink, S.C., Sage, F., Vertesy, A., Spanjaard, B., Peterson-Maduro, J., Baron, C.S., Robin, C. and van Oudenaarden, A.
Nature Methods 14
(10): 935-936.
29 September 2017
Single-cell transcriptomics enters the age of mass production.
Junker, J.P. and van Oudenaarden, A.
Molecular Cell 58
(4): 563-564.
21 May 2015
Kainmüller, Dagmar
Metrics reloaded: recommendations for image analysis validation.
Maier-Hein, L., Reinke, A., Godau, P., Tizabi, M.D., Buettner, F., Christodoulou, E., Glocker, B., Isensee, F., Kleesiek, J., Kozubek, M., Reyes, M., Riegler, M.A., Wiesenfarth, M., Kavur, A.E., Sudre, C.H., Baumgartner, M., Eisenmann, M., Heckmann-Nötzel, D., Rädsch, T., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Blaschko, M.B., Cardoso, M.J., Cheplygina, V., Cimini, B.A., Collins, G.S., Farahani, K., Ferrer, L., Galdran, A., van Ginneken, B., Haase, R., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Karthikesalingam, A., Kofler, F., Kopp-Schneider, A., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G., Madani, A., Maier-Hein, K., Martel, A.L., Mattson, P., Meijering, E., Menze, B., Moons, K.G.M., Müller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rajpoot, N., Rieke, N., Saez-Rodriguez, J., Sánchez, C.I., Shetty, S., van Smeden, M., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Van Calster, B., Varoquaux, G. and Jäger, P.F.
Nature Methods 21
(2): 195-212.
12 February 2024
CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting.
Graham, S., Vu, Q.D., Jahanifar, M., Weigert, M., Schmidt, U., Zhang, W., Zhang, J., Yang, S., Xiang, J., Wang, X., Rumberger, J.L., Baumann, E., Hirsch, P., Liu, L., Hong, C., Aviles-Rivero, A.I., Jain, A., Ahn, H., Hong, Y., Azzuni, H., Xu, M., Yaqub, M., Blache, M.C., Piégu, B., Vernay, B., Scherr, T., Böhland, M., Löffler, K., Li, J., Ying, W., Wang, C., Snead, D., Raza, S.E.A., Minhas, F. and Rajpoot, N.M.
Medical Image Analysis 92
: 103047.
February 2024
Understanding metric-related pitfalls in image analysis validation.
Reinke, A., Tizabi, M.D., Baumgartner, M., Eisenmann, M., Heckmann-Nötzel, D., Kavur, A.E., Rädsch, T., Sudre, C.H., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Buettner, F., Cardoso, M.J., Cheplygina, V., Chen, J., Christodoulou, E., Cimini, B.A., Farahani, K., Ferrer, L., Galdran, A., van Ginneken, B., Glocker, B., Godau, P., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Isensee, F., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Kleesiek, J., Kofler, F., Kooi, T., Kopp-Schneider, A., Kozubek, M., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G., Madani, A., Maier-Hein, K., Martel, A.L., Meijering, E., Menze, B., Moons, K.G.M., Müller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rafelski, S.M., Rajpoot, N., Reyes, M., Riegler, M.A., Rieke, N., Saez-Rodriguez, J., Sánchez, C.I., Shetty, S., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Van Calster, B., Varoquaux, G., Yaniv, Z.R., Jäger, P.F. and Maier-Hein, L.
Nature Methods 21
(2): 182–194.
February 2024
Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering.
Liu, C.C., Greenwald, N.F., Kong, A., McCaffrey, E.F., Leow, K.X., Mrdjen, D., Cannon, B.J., Rumberger, J.L., Varra, S.R. and Angelo, M.
Nature Communications 14
(1): 4618.
1 August 2023
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations.
Malin-Mayor, C., Hirsch, P., Guignard, L., McDole, K., Wan, Y., Lemon, W.C., Kainmueller, D., Keller, P.J., Preibisch, S. and Funke, J.
Nature Biotechnology 44
(1): 44-49.
January 2023
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60
(6): 2102725.
1 December 2022
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
Michalick, L., Weidenfeld, S., Grimmer, B., Fatykhova, D., Solymosi, P.D., Behrens, F., Dohmen, M., Brack, M.C., Schulz, S., Thomasch, E., Simmons, S., Müller-Redetzky, H., Suttorp, N., Kurth, F., Neudecker, J., Toennies, M., Bauer, T.T., Eggeling, S., Corman, V.M., Hocke, A.C., Witzenrath, M., Hippenstiel, S. and Kuebler, W.M.
European Respiratory Journal 57
(3): 2002384.
11 March 2021
Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
Veenvliet, J.V., Bolondi, A., Kretzmer, H., Haut, L., Scholze-Wittler, M., Schifferl, D., Koch, F., Guignard, L., Kumar, A.S., Pustet, M., Heimann, S., Buschow, R., Wittler, L., Timmermann, B., Meissner, A. and Herrmann, B.G.
Science 370
(6522): eaba4937.
11 December 2020
Kaminski, Michael (BIMSB)
Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.
Ilia, K., Shakiba, N., Bingham, T., Jones, R.D., Kaminski, M.M., Aravera, E., Bruno, S., Palacios, S., Weiss, R., Collins, J.J., Del Vecchio, D. and Schlaeger, T.M.
Science Advances 9
(48): eadg8495.
December 2023
HNF1B alters an evolutionarily conserved nephrogenic program of target genes.
Grand, K., Stoltz, M., Rizzo, L., Röck, R., Kaminski, M.M., Salinas, G., Getwan, M., Naert, T., Pichler, R. and Lienkamp, S.S.
Journal of the American Society of Nephrology 34
(3): 412-432.
March 2023
Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease.
Pichler, R., Rizzo, L., Tröndle, K., Bühler, M., Brucker, H., Müller, A.L., Grand, K., Farè, S., Viau, A., Kaminski, M.M., Kuehn, E.W., Koch, F., Zimmermann, S., Koltay, P. and Lienkamp, S.S.
Biomaterials 291
: 121910.
December 2022
Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto, M., Kaminski, M.M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A.J., Tan, X., Kim, H., Dighe, A.S., Collins, J.J. and Stevens, M.M.
Nature Nanotechnology 17
(10): 1120-1126.
October 2022
CRISPR-based diagnostics.
Kaminski, M.M., Abudayyeh, O.O., Gootenberg, J.S., Zhang, F. and Collins, J.J.
Nature Biomedical Engineering 5
(7): 643-656.
July 2021
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
Kaminski, M.M., Alcantar, M.A., Lape, I.T., Greensmith, R., Huske, A.C., Valeri, J.A., Marty, F.M., Klämbt, V., Azzi, J., Akalin, E., Riella, L.V. and Collins, J.J.
Nature Biomedical Engineering 4
(6): 601-609.
June 2020
Kaplan, Oktay
G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch.
Kaplan, O.I., Berber, B., Hekim, N. and Doluca, O.
Nucleic Acids Research 44
(19): 9083-9095.
2 November 2016
Keller, Ulrich
New cardiovascular biomarkers in patients with advanced cancer – a prospective study comparing MR-proADM, MR-proANP, copeptin, high-sensitivity troponin T and NT-proBNP.
Anker, M.S., Lück, L.C., Khan, M.S., Porthun, J., Hadzibegovic, S., Lena, A., Wilkenshoff, U., Weinländer, P., Evertz, R., Totzeck, M., Mahabadi, A.A., Rassaf, T., Anker, S.D., Bullinger, L., Keller, U., Karakas, M., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure
26 November 2024
(In Press)
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy.
Gross, S., Ihlow, J., Busack, L., Adamiak, K., Schrezenmeier, J., Jesse, J., Schwarz, M., Flörcken, A., Vuong, L.G., Rieger, K., Krönke, J., le Coutre, P., Boldt, V., von Brünneck, A.C., Horst, D., Burmeister, T., Blau, I.W., Keller, U., Bullinger, L. and Westermann, J.
Blood Cancer Journal 14
(1): 160.
16 September 2024
Teclistamab-induced remission in refractory systemic lupus erythematosus.
Alexander, T., Krönke, J., Cheng, Q., Keller, U. and Krönke, G.
New England Journal of Medicine 391
(9): 864-866.
5 September 2024
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
A hypoxia-epigenetics axis drives EMT in pancreatic cancer.
Wirth, M. and Schneider, G.
Cancer Research 84
(11): 1739-1741.
1 June 2024
Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022.
Baumgartner, F., Baer, C., Bamopoulos, S.A., Ayoub, E., Truger, M., Meggendorfer, M., Lenk, M., Hoermann, G., Hutter, S., Müller, H., Walter, W., Mueller, M.L., Nadarajah, Ni., Blombery, P., Keller, U., Kern, W., Haferlach, C. and Haferlach, T.
Blood 143
(12): 1139-1156.
21 March 2024
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.
Dönig, J., Mende, H., Davila Gallesio, J., Wagner, K., Hotz, P., Schunck, K., Piller, T., Hölper, S., Uhan, S., Kaulich, M., Wirth, M., Keller, U., Tascher, G., Bohnsack, K.E. and Müller, S.
Nature Communications 14
(1): 8121.
8 December 2023
Leveraging large language models for decision support in personalized oncology.
Benary, M., Wang, X.D., Schmidt, M., Soll, D., Hilfenhaus, G., Nassir, M., Sigler, C., Knödler, M., Keller, U., Beule, D., Keilholz, U., Leser, U. and Rieke, D.T.
JAMA Network Open 6
(11): e2343689.
November 2023
Cardiovascular health-related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ-C30 questionnaire.
Anker, M.S., Potthoff, S.K., Lena, A., Porthun, J., Hadzibegovic, S., Evertz, R., Denecke, C., Fröhlich, A.K., Sonntag, F., Regitz-Zagrosek, V., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Spertus, J.A., Anker, S.D., Karakas, M., Bullinger, L., Keller, U., Landmesser, U., Butler, J. and von Haehling, S.
European Journal of Heart Failure 25
(9): 1635-1647.
September 2023
Clinical and prognostic relevance of cardiac wasting in patients with advanced cancer.
Lena, A., Wilkenshoff, U., Hadzibegovic, S., Porthun, J., Rösnick, L., Fröhlich, A.K., Zeller, T., Karakas, M., Keller, U., Ahn, J., Bullinger, L., Riess, H., Rosen, S.D., Lyon, A.R., Lüscher, T.F., Totzeck, M., Rassaf, T., Burkhoff, D., Mehra, M.R., Bax, J.J., Butler, J., Edelmann, F., Haverkamp, W., Anker, S.D., Packer, M., Coats, A.J.S., von Haehling, S., Landmesser, U. and Anker, M.S.
Journal of the American College of Cardiology 81
(16): 1569-1586.
25 April 2023
The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann, C., Spallek, R., Karpiuk, O., Heider, M., Schäffer, I., Zecha, J., Klaeger, S., Walzik, M., Öllinger, R., Engleitner, T., Wirth, M., Keller, U., Krönke, J., Rudelius, M., Kossatz, S., Rad, R., Kuster, B. and Bassermann, F.
EMBO Journal 41
(20): e110871.
17 October 2022
Reduced splenic uptake on (68)Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis.
Kraus, S., Klassen, P., Kircher, M., Dierks, A., Habringer, S., Gäble, A., Kortüm, K.M., Weinhold, N., Ademaj-Kospiri, V., Werner, R.A., Schirbel, A., Buck, A.K., Herhaus, P., Wester, H.J., Rosenwald, A., Weber, W.A., Einsele, H., Keller, U., Rasche, L. and Lapa, C.
Theranostics 12
(13): 5986-5994.
8 August 2022
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M., Böger, M., Yousefian, S., Grunert, C., Zhang, L., Hotz, P.W., Gottschlich, A., Köse, H., Isaakidis, K., Vonficht, D., Grünschläger, F., Rohleder, E., Wagner, K., Dönig, J., Igl, V., Brzezicha, B., Baumgartner, F., Habringer, S., Löber, J., Chapuy, B., Weidinger, C., Kobold, S., Haas, S., Busse, A.B., Müller, S., Wirth, M., Schick, M. and Keller, U.
Journal of Clinical Investigation 132
(9): e152383.
2 May 2022
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J., Bamopoulos, S.A., Köse, H., Orben, F., Zang, C., Pons, M., den Dekker, A.T., Brouwer, R.W.W., Baluapuri, A., Habringer, S., Reichert, M., Illendula, A., Krämer, O.H., Schick, M., Wolf, E., van IJcken, W.F.J., Esposito, I., Keller, U., Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119
(9): e2105691119.
1 March 2022
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13
(1): 1009.
23 February 2022
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Schick, M., Zhang, L., Maurer, S., Maurer, H.C., Isaakaidis, K., Schneider, L., Patra, U., Schunck, K., Rohleder, E., Hofstetter, J., Baluapuri, A., Scherger, A.K., Slotta-Huspenina, J., Hettler, F., Weber, J., Engleitner, T., Maresch, R., Slawska, J., Lewis, R., Istvanffy, R., Habringer, S., Steiger, K., Baiker, A., Oostendorp, R.A.J., Miething, C., Lenhof, H.P., Bassermann, F., Chapuy, B., Wirth, M., Wolf, E., Rad, R., Müller, S. and Keller, U.
Nature Communications 13
(1): 281.
12 January 2022
Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
Kayser, S., Schlenk, R.F., Lebon, D., Carre, M., Götze, K.S., Stölzel, F., Berceanu, A., Schäfer-Eckart, K., Peterlin, P., Hicheri, Y., Rahme, R., Raffoux, E., Chermat, F., Krause, S.W., Aulitzky, W.E., Rigaudeau, S., Noppeney, R., Berthon, C., Görner, M., Jost, E., Carassou, P., Keller, U., Orvain, C., Braun, T., Saillard, C., Arar, A., Kunzmann, V., Wemeau, M., De Wit, M., Niemann, D., Bonmati, C., Schwänen, C., Abraham, J., Aljijakli, A., Haiat, S., Krämer, A., Reichle, A., Gnadler, M., Willekens, C., Spiekermann, K., Hiddemann, W., Müller-Tidow, C., Thiede, C., Röllig, C., Serve, H., Bornhäuser, M., Baldus, C.D., Lengfelder, E., Fenaux, P., Platzbecker, U. and Adès, L.
Haematologica 106
(12): 3100-3106.
December 2021
CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.
Lewis, R., Maurer, H.C., Singh, N., Gonzalez-Menendez, I., Wirth, M., Schick, M., Zhang, L., Isaakidis, K., Scherger, A.K., Schulze, V., Lu, J., Zenz, T., Steiger, K., Rad, R., Quintanilla-Martinez, L., Espeli, M., Balabanian, K., Keller, U. and Habringer, S.
Leukemia 35
: 2895-2905.
October 2021
High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
Çınar, Ö., Brzezicha, B., Grunert, C., Kloetzel, P.M., Beier, C., Peuker, C.A., Keller, U., Pezzutto, A. and Busse, A.
Journal for ImmunoTherapy of Cancer 9
(7): e002410.
30 July 2021
PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial.
Kreissl, S., Goergen, H., Buehnen, I., Kobe, C., Moccia, A., Greil, R., Eichenauer, D.A., Zijlstra, J.M., Markova, J., Meissner, J., Feuring-Buske, M., Soekler, M., Beck, H.J., Willenbacher, W., Ludwig, W.D., Pabst, T., Topp, M.S., Hitz, F., Bentz, M., Keller, U.B., Kühnhardt, D., Ostermann, H., Hertenstein, B., Aulitzky, W., Maschmeyer, G., Vieler, T., Eich, H., Baues, C., Stein, H., Fuchs, M., Diehl, V., Dietlein, M., Engert, A. and Borchmann, P.
Lancet Haematology 8
(6): e398-e409.
June 2021
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M., Eichner, R., Stroh, J., Morath, V., Kuisl, A., Zecha, J., Lawatscheck, J., Baek, K., Garz, A.K., Rudelius, M., Deuschle, F.C., Keller, U., Lemeer, S., Verbeek, M., Götze, K.S., Skerra, A., Weber, W.A., Buchner, J., Schulman, B.A., Kuster, B., Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81
(6): 1170-1186.
18 March 2021
Early response to first-line anti-PD-1 treatment in Hodgkin lymphoma: a PET-based analysis from the prospective, randomized phase II NIVAHL trial.
Voltin, C.A., Mettler, J., van Heek, L., Goergen, H., Müller, H., Baues, C., Keller, U., Meissner, J., Trautmann-Grill, K., Kerkhoff, A., Fuchs, M., Sasse, S., von Tresckow, B., Dietlein, M., Borchmann, P., Engert, A., Kobe, C. and Bröckelmann, P.J.
Clinical Cancer Research 27
(2): 402-407.
January 2021
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke, S., Bröckelmann, P.J., Iaccarino, I., Garcia-Marquez, M., Borchmann, S., Jochims, F., Kotrova, M., Pal, K., Brüggemann, M., Hartmann, E., Sasse, S., Kobe, C., Mathas, S., Soekler, M., Keller, U., Bormann, M., Zimmermann, A., Richter, J., Fuchs, M., von Tresckow, B., Borchmann, P., Schlößer, H., von Bergwelt-Baildon, M., Rosenwald, A., Engert, A. and Klapper, W.
Blood 136
(25): 2851-2863.
17 December 2020
CXCR4-targeted PET imaging of central nervous system B-cell lymphoma.
Herhaus, P., Lipkova, J., Lammer, F., Yakushev, I., Vag, T., Slotta-Huspenina, J., Habringer, S., Lapa, C., Pukrop, T., Hellwig, D., Wiestler, B., Buck, A.K., Deckert, M., Wester, H.J., Bassermann, F., Schwaiger, M., Weber, W.A., Menze, B. and Keller, U.
Journal of Nuclear Medicine 61
(12): 1765-1771.
1 December 2020
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Biederstädt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H.P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G. and Keller, U.
Gut 69
(8): 1472-1482.
August 2020
Efficacy of nivolumab and AVD in early-stage unfavorable classic Hodgkin lymphoma: the randomized phase 2 German Hodgkin Study Group NIVAHL trial.
Bröckelmann, P.J., Goergen, H., Keller, U., Meissner, J., Ordemann, R., Halbsguth, T.V., Sasse, S., Sökler, M., Kerkhoff, A., Mathas, S., Hüttmann, A., Bormann, M., Zimmermann, A., Mettler, J., Fuchs, M., von Tresckow, B., Baues, C., Rosenwald, A., Klapper, W., Kobe, C., Borchmann, P. and Engert, A.
JAMA Oncology 6
(6): 872-880.
June 2020
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T., Zhou, X., Kosla, J., Adili, A., Garcia Beccaria, M., Kotsiliti, E., Pfister, D., Johlke, A.L., Sinha, A., Sankowski, R., Schick, M., Lewis, R., Dokalis, N., Seubert, B., Höchst, B., Inverso, D., Heide, D., Zhang, W., Weihrich, P., Manske, K., Wohlleber, D., Anton, M., Hoellein, A., Seleznik, G., Bremer, J., Bleul, S., Augustin, H.G., Scherer, F., Koedel, U., Weber, A., Protzer, U., Förster, R., Wirth, T., Aguzzi, A., Meissner, F., Prinz, M., Baumann, B., Höpken, U.E., Knolle, P.A., von Baumgarten, L., Keller, U. and Heikenwalder, M.
Cancer Cell 36
(3): 250-267.
16 September 2019
Radioimmunotherapy in relapsed/refractory mantle cell lymphoma patients: final results of a European MCL network phase II trial.
Ferrero, S., Pastore, A., Scholz, C.W., Forstpointner, R., Pezzutto, A., Bergmann, L., Truemper, L., Finke, J., Keller, U., Ghione, P., Passera, R., Hiddemann, W., Weigert, O., Unterhalt, M. and Dreyling, M.
Leukemia 30
(4): 984-987.
April 2016
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
(90)Yttrium-ibritumomab-tiuxetan as first-line treatment for follicular lymphoma: 30 months of follow-up data from an international multicenter phase II clinical trial.
Scholz, C.W., Pinto, A., Linkesch, W., Lindén, O., Viardot, A., Keller, U., Hess, G., Lastoria, S., Lerch, K., Frigeri, F., Arcamone, M., Stroux, A., Frericks, B., Pott, C. and Pezzutto, A.
Journal of Clinical Oncology 31
(3): 308-313.
20 January 2013
Kemmner, Wolfgang
Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma.
Juettner, S., Wissmann, C., Joens, T., Vieth, M., Hertel, J., Gretschel, S., Schlag, P.M., Kemmner, W. and Hoecker, M.
Journal of Clinical Oncology 24
(2): 228-240.
10 January 2006
Laser microdissection of a colon cancer specimen with subsequent RNA isolation, mRNA amplification and microarray hybridization.
Stoinski-Bungs, E., Seeger, S., Kemmner, W., Scheinert, P. and Krupp, G.
Nature Methods Application Notes
: an10-an11.
1 January 2006
Kempa, Stefan (BIMSB)
p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10
(43): eadp8783.
25 October 2024
Targeting HFpEF: unlocking the potential of glucagon receptor blockade.
Santiago Padilla, L. and Schiattarella, G.G.
Circulation Research 135
(5): 629-631.
16 August 2024
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20
(10): 1544-1552.
October 2023
Salt sensitivity includes effects on immune cell signalling and metabolism.
Müller, D.N., Geisberger, S., Kleinewietfeld, M. and Jantsch, J.
Nature Reviews Immunology 23
(6): 341-342.
June 2023
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F., Hamad, I., Arroyo Hornero, R., Geisberger, S., Roels, J., Van Zeebroeck, L., Dyczko, A., van Gisbergen, M.W., Kurniawan, H., Wagner, A., Yosef, N., Weiss, S.N.Y., Schmetterer, K.G., Schröder, A., Krampert, L., Haase, S., Bartolomaeus, H., Hellings, N., Saeys, Y., Dubois, L.J., Brenner, D., Kempa, S., Hafler, D.A., Stegbauer, J., Linker, R.A., Jantsch, J., Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35
(2): 299-315.
7 February 2023
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 33
(8): 1528-1545.
August 2022
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C.H., Müller, S., Mastrobuoni, G., Hazapis, O.G., Del Giudice, S., Schwefel, D., Bley, N., Voigt, F., Chao, J.A., Kempa, S., Hüttelmaier, S., Selbach, M. and Landthaler, M.
Nature Communications 13
(1): 2727.
18 May 2022
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144
(2): 144-158.
13 July 2021
Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W., Jürges, C.S., Hennig, T., Wyler, E., Prusty, B., Rutkowski, A.J., L'hernault, A., Djakovic, L., Göbel, M., Döring, K., Menegatti, J., Antrobus, R., Matheson, N.J., Künzig, F.W.H., Mastrobuoni, G., Bielow, C., Kempa, S., Liang, C., Dandekar, T., Zimmer, R., Landthaler, M., Grässer, F., Lehner, P.J., Friedel, C.C., Erhard, F. and Dölken, L.
Nature Communications 11
(1): 2038.
27 April 2020
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., Silveira Vidal, R., Schülein-Völk, C., Chang, Y.C., Ade, C.P., Mastrobuoni, G., Girard, C., Kumar, A., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D. and Eilers, M.
Molecular Cell 77
(6): 1322-1339.
19 March 2020
Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G.I., Eilers, E., Bader, V., Haase, S., Kaisler, J., David, C., Schneider, R., Troisi, R., Zent, D., Hegelmaier, T., Dokalis, N., Gerstein, S., Del Mare-Roumani, S., Amidror, S., Staszewski, O., Poschmann, G., Stühler, K., Hirche, F., Balogh, A., Kempa, S., Träger, P., Zaiss, M.M., Holm, J.B., Massa, M.G., Nielsen, H.B., Faissner, A., Lukas, C., Gatermann, S.G., Scholz, M., Przuntek, H., Prinz, M., Forslund, S.K., Winklhofer, K.F., Müller, D.N., Linker, R.A., Gold, R. and Haghikia, A.
Cell 180
(6): 1067-1080.
19 March 2020
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M., Gonzalez, E., Teixeira da Costa, A.R., Wask, L., Gravenstein, I., Pardo, M., Pietzke, M., Gurumurthy, R.K., Angermann, J., Laudeley, R., Glage, S., Meyer, M., Chumduri, C., Kempa, S., Dinkel, K., Unger, A., Klebl, B., Klos, A. and Meyer, T.F.
Cell Host & Microbe 23
(5): 661-671.
9 May 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S., Witte, N., Weber, P., Goehring, I., Tolkachov, A., von Loeffelholz, C., Döcke, S., Bauer, M., Stockmann, M., Pfeiffer, A.F.H., Birkenfeld, A.L., Pietzke, M., Kempa, S., Muenzner, M. and Schupp, M.
Nature Communications 8
(1): 384.
30 August 2017
The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure, F.R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C.P., Mastrobuoni, G., Vanselow, J.T., Schlosser, A., Wolf, E., Kempa, S. and Eilers, M.
EMBO Journal 36
(13): 1854-1868.
3 July 2017
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G., Raffel, S., Sormani, M., Zanardi, F., Lonardi, S., Zasada, C., Perucho, L., Petrocelli, V., Haake, A., Lee, A.K., Bugatti, M., Paul, U., Van Anken, E., Pasqualucci, L., Rabadan, R., Siebert, R., Kempa, S., Ponzoni, M., Facchetti, F., Rajewsky, K. and Casola, S.
Nature 546
(7657): 302-306.
8 June 2017
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356
(6335): 307-311.
21 April 2017
OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
Roest, H.L., Sachsenberg, T., Aiche, S., Bielow, C., Weisser, H., Aicheler, F., Andreotti, S., Ehrlich, H.C., Gutenbrunner, P., Kenar, E., Liang, X., Nahnsen, S., Nilse, L., Pfeuffer, J., Rosenberger, G., Rurik, M., Schmitt, U., Veit, J., Walzer, M., Wojnar, D., Wolski, W.E., Schilling, O., Choudhary, J.S., Malmstroem, L., Aebersold, R., Reinert, K. and Kohlbacher, O.
Nature Methods 13
(9): 741-748.
September 2016
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M.N., Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126
(7): 2706-2720.
1 July 2016
A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer.
von Eyss, B., Jaenicke, L.A., Kortlever, R.M., Royla, N., Wiese, K.E., Letschert, S., McDuffus, L.A., Sauer, M., Rosenwald, A., Evan, G.I., Kempa, S. and Eilers, M.
Cancer Cell 28
(6): 743-757.
14 December 2015
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.H., May, C., Wilck, N., Balogh, A., Ostermann, A.I., Schebb, N.H., Akkad, D.A., Grohme, D.A., Kleinewietfeld, M., Kempa, S., Thöne, J., Demir, S., Müller, D.N., Gold, R. and Linker, R.A.
Immunity 43
(4): 817-829.
20 October 2015
Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M. and Obermayer, B.
Genome Biology 16
: 179.
14 September 2015
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.
Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., Bomze, D., Elena-Herrmann, B., Scherf, T., Nissim-Rafinia, M., Kempa, S., Itskovitz-Eldor, J., Meshorer, E., Aberdam, D. and Nahmias, Y.
Cell Metabolism 21
(3): 392-402.
3 March 2015
GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C., Moroni, M., Lima, W.C., Wende, H., Kirchner, M., Adelfinger, L., Schrenk-Siemens, K., Tappe-Theodor, A., Wetzel, C., Kuich, P.H., Gassmann, M., Roggenkamp, D., Bettler, B., Lewin, G.R., Selbach, M. and Siemens, J.
Cell 160
(4): 759-770.
12 February 2015
MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H., Schueler, M., Munschauer, M., Mastrobuoni, G., Chen, W., Kempa, S., Dieterich, C. and Landthaler, M.
Molecular Cell 54
(4): 573-585.
22 May 2014
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu, L., Ulbrich, J., Mueller, J., Wuestefeld, T., Aeberhard, L., Kress, T.R., Muthalagu, N., Rycak, L., Rudalska, R., Moll, R., Kempa, S., Zender, L., Eilers, M. and Murphy, D.J.
Nature 483
(7391): 608-612.
29 March 2012
In vivo and transcriptome-wide identification of RNA binding protein target sites.
Jungkamp, A.C., Stoeckius, M., Mecenas, D., Gruen, D., Mastrobuoni, G., Kempa, S. and Rajewsky, N.
Molecular Cell 44
(5): 828-840.
9 December 2011
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C., Wang, Y., Gruen, D., Mastrobuoni, G., You, X., Tolle, D., Dodt, M., Mackowiak, S.D., Gogol-Doering, A., Oenal, P., Rybak, A., Ross, E., Alvarado, A.S., Kempa, S., Dieterich, C., Rajewsky, N. and Chen, W.
Genome Research 21
(7): 1193-1200.
July 2011
Kempermann, Gerd
They are not too excited: the possible role of adult-born neurons in epilepsy.
Kempermann, G.
Neuron 52
(6): 935-937.
21 December 2006
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P.M., Wolf, S., Hoertnagl, H., Raine, C.S., Schneider-Stock, R., Nitsch, R. and Ullrich, O.
Neuron 49
(1): 67-79.
5 January 2006
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis.
Berliocchi, L., Fava, E., Leist, M., Horvat, V., Dinsdale, D., Read, D. and Nicotera, P.
Journal of Cell Biology 168
(4): 607-618.
14 February 2005
Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells.
Emsley, J.G., Mitchell, B.D., Kempermann, G. and Macklis, J.D.
Progress in Neurobiology 75
: 321-341.
1 January 2005
Milestones of neuronal development in the adult hippocampus.
Kempermann, G., Jessberger, S., Steiner, B. and Kronenberg, G.
Trends in Neurosciences 27
(8): 447-452.
1 August 2004
The Collaborative Cross, a community resource for the genetic analysis of complex traits.
Churchill, G., Airey, D.C., Allayee, H., Angel, J.M., Attie, A.D., Beatty, J., Beavis, W.D., Belknap, J.K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K.W., Buck, K.J., Buckler, E., Burmeister, M., Chesler, E.J., Cheverud, J.M., Clapcote, S., Cook, M.N., Cox, R.D., Crabbe, J.C., Crusio, W.E., Darvasi, A., Deschnepper, C.F., Doerge, R.W., Farber, C.R., Forejt, J., Gaile, D., Garlow, S.J., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W.K., de Haan, G., Hayes, N.L., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H.C., Iraqi, F.A., Ivandic, B., Jacob, H.J., Jansen, R.C., Jjepsen, K.J., Johnson, D.K., Johnson, T.E., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, R.F., Llamas, B., Lammert, F., Lassalle, J.M., Lowenstein, P.R., Lu, L., Lusiss, A., Manly, K.F., Marcucio, R., Matthews, D., Medrano, J.F., Miller, D.R., Mittleman, G., Mock, B.A., Mogil, J.S., Montagutelli, X., Morahan, G., Morris, D.G., Mott, R., Nadeau, J.H., Nagase, H., Nowakowski, R.S., O'Hara, B.F., Osadchuk, A.V., Page, G.P., Paigen, B., Paigen, K., Palmer, A.A., Pan, H.J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, D.R., Qi, Z.H., Reeves, R.H., Roder, J., Rosen, G.D., Schadt, E.E., Schalkwyk, L.C., Seltzer, Z., Shimomura, K., Shou, S.M., Sillanpaeae, M.J., Siracusa, L.D., Snoeck, H.W., Spearow, J.L., Svenson, K., Tarantino, L.M., Threadgill, D., Toth, L.A., Valdar, W., de Villena, F.P.M., Warden, C., Whatley, S., Williams, R.W., Wiltshire, T., Yi, N.J., Zhang, D.B., Zhang, M. and Zou, F.
Nature Genetics 36
: 1133-1137.
1 January 2004
Neuroscience - Microglia: The enemy within?
Kempermann, G. and Neumann, H.
Science 302
(5651): 1689-1690.
5 December 2003
The nature and identification of quantitative trait loci: a community's view.
Abiola, O., Angel, J.M., Avner, P., Bachmanov, A.A., Belknap, J.K., Bennett, B., Blankenhorn, E.P., Blizard, D.A., Bolivar, V., Brockmann, G.A., Buck, K.J., Bureau, J.F., Casley, W.L., Chesler, E.J., Cheverud, J.M., Churchill, G.A., Cook, M., Crabbe, J.C., Crusio, W.E., Darvasi, A., de Haan, G., Dermant, P., Doerge, R.W., Elliot, R.W., Farber, C.R., Flaherty, L., Flint, J., Gershenfeld, H., Gibson, J.P., Gu, J., Gu, W., Himmelbauer, H., Hitzemann, R., Hsu, H.C., Hunter, K., Iraqi, F.F., Jansen, R.C., Johnson, T.E., Jones, B.C., Kempermann, G., Lammert, F., Lu, L., Manly, K.F., Matthews, D.B., Medrano, J.F., Mehrabian, M., Mittlemann, G., Mock, B.A., Mogil, J.S., Montagutelli, X., Morahan, G., Mountz, J.D., Nagase, H., Nowakowski, R.S., O'Hara, B.F., Osadchuk, A.V., Paigen, B., Palmer, A.A., Peirce, J.L., Pomp, D., Rosemann, M., Rosen, G.D., Schalkwyk, L.C., Seltzer, Z., Settle, S., Shimomura, K., Shou, S., Sikela, J.M., Siracusa, L.D., Spearow, J.L., Teuscher, C., Threadgill, D.W., Toth, L.A., Toye, A.A., Vadasz, C., Van Zant, G., Wakeland, E., Williams, R.W., Zhang, H.G. and Zou, F.
Nature Reviews Genetics 4
(11): 911-916.
1 November 2003
Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.
Priller, J., Persons, D.A., Klett, F.F., Kempermann, G., Kreutzberg, G.W. and Dirnagl, U.
Journal of Cell Biology 155
(5): 733-738.
26 November 2001
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.
Hammes, A., Guo, J.K., Lutsch, G., Leheste, J.R., Landrock, D., Ziegler, U., Gubler, M.C. and Schedl, A.
Cell 106
(3): 319-329.
10 August 2001
Smooth-muscle contraction without smooth-muscle myosin.
Morano, I., Chai, G.X., Baltas, L.G., Lamounier-Zepter, V., Lutsch, G., Kott, M., Haase, H. and Bader, M.
Nature Cell Biology 2
(6): 371-375.
1 June 2000
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
Kettenmann, Helmut
Microglia states and nomenclature: A field at its crossroads.
Paolicelli, R.C., Sierra, A., Stevens, B., Tremblay, M.E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G.C., Butovsky, O., Carson, M.J., Castellano, B., Colonna, M., Cowley, S.A., Cunningham, C., Davalos, D., De Jager, P.L., de Strooper, B., Denes, A., Eggen, B.J.L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C.K., Gokce, O., Gomez-Nicola, D., González, B., Gordon, S., Graeber, M.B., Greenhalgh, A.D., Gressens, P., Greter, M., Gutmann, D.H., Haass, C., Heneka, M.T., Heppner, F.L., Hong, S., Hume, D.A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B.W., Miron, V.E., Molofsky, A.V., Monje, M., Mracsko, E., Nadjar, A., Neher, J.J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V.H., Popovich, P.G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R.M., Salter, M.W., Schaefer, A., Schafer, D.P., Schwartz, M., Simons, M., Smith, C.J., Streit, W.J., Tay, T.L., Tsai, L.H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S.A., Wu, L.J. and Wyss-Coray, T.
Neuron 110
(21): 3458-3483.
2 November 2022
Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J.P., Petzold, G.C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N.J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D.E., Bonvento, G., Butt, A.M., Chen, W.T., Cohen-Salmon, M., Cunningham, C., Deneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J.E., Goldman, S.A., Götz, M., Gutiérrez, A., Haydon, P.G., Heiland, D.H., Hol, E.M., Holt, M.G., Iino, M., Kastanenka, K.V., Kettenmann, H., Khakh, B.S., Koizumi, S., Lee, C.J., Liddelow, S.A., MacVicar, B.A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A.V., Murai, K.K., Norris, C.M., Okada, S., Oliet, S.H.R., Oliveira, J.F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B.G., Pfrieger, F.W., Poskanzer, K.E., Quintana, F.J., Ransohoff, R.M., Riquelme-Perez, M., Robel, S., Rose, C.R., Rothstein, J.D., Rouach, N., Rowitch, D.H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R.A., Vitorica, J., Wanner, I.B., Wood, L.B., Wu, J., Zheng, B., Zimmer, E.R., Zorec, R., Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24
(3): 312-325.
March 2021
Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A., Haage, V., Yang, S., Wegner, S., Ersoy, B., Ugursu, B., Rex, A., Kronenberg, G., Gertz, K., Endres, M., Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91
: 89-104.
January 2021
Microglia/brain macrophages as central drivers of brain tumor pathobiology.
Gutmann, D.H. and Kettenmann, H.
Neuron 104
(3): 442-449.
6 November 2019
Cien años de microglía: milestones in a century of microglial research.
Sierra, A., Paolicelli, R.C. and Kettenmann, H.
Trends in Neurosciences 42
(11): 778-792.
November 2019
Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135
(4): 551.
April 2018
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.
Szulzewsky, F., Schwendinger, N., Güneykaya, D., Cimino, P.J., Hambardzumyan, D., Synowitz, M., Holland, E.C. and Kettenmann, H.
Neuro-Oncology 20
(3): 355-366.
19 February 2018
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A., Dejanovic, B., Hetsch, F., Semtner, M., Fusca, D., Arjune, S., Santamaria-Araujo, J.A., Winkelmann, A., Ayton, S., Bush, A.I., Kloppenburg, P., Meier, J.C., Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127
(12): 4365-4378.
1 December 2017
Building bridges through science.
Lissek, T., Adams, M., Adelman, J., Ahissar, E., Akaaboune, M., Akil, H., al'Absi, M., Arain, F., Arango-Lasprilla, J.C., Atasoy, D., Avila, J., Badawi, A., Bading, H., Baig, A.M., Baleriola, J., Belmonte, C., Bertocchi, I., Betz, H., Blakemore, C., Blanke, O., Boehm-Sturm, P., Bonhoeffer, T., Bonifazi, P., Brose, N., Campolongo, P., Celikel, T., Chang, C.C., Chang, T.Y., Citri, A., Cline, H.T., Cortes, J.M., Cullen, K., Dean, K., Delgado-Garcia, J.M., Desroches, M., Disterhoft, J.F., Dowling, J.E., Draguhn, A., El-Khamisy, S.F., El Manira, A., Enam, S.A., Encinas, J.M., Erramuzpe, A., Esteban, J.A., Fariñas, I., Fischer, E., Fukunaga, I., Gabilondo, I., Ganten, D., Gidon, A., Gomez-Esteban, J.C., Greengard, P., Grinevich, V., Gruart, A., Guillemin, R., Hariri, A.R., Hassan, B., Haeusser, M., Hayashi, Y., Hussain, N.K., Jabbar, A.A., Jaber, M., Jahn, R., Janahi, E.M., Kabbaj, M., Kettenmann, H., Kindt, M., Knafo, S., Köhr, G., Komai, S., Krugers, H., Kuhn, B., Ghazal, N.L., Larkum, M.E., London, M., Lutz, B., Matute, C., Martinez-Millan, L., Maroun, M., McGaugh, J., Moustafa, A.A., Nasim, A., Nave, K.A., Neher, E., Nikolich, K., Outeiro, T., Palmer, L.M., Penagarikano, O., Perez-Otano, I., Pfaff, D.W., Poucet, B., Rahman, A.U., Ramos-Cabrer, P., Rashidy-Pour, A., Roberts, R.J., Rodrigues, S., Sanes, J.R., Schaefer, A.T., Segal, M., Segev, I., Shafqat, S., Siddiqui, N.A., Soreq, H., Soriano-Garcia, E., Spanagel, R., Sprengel, R., Stuart, G., Südhof, T.C., Tønnesen, J., Treviño, M., Uthman, B.M., Venter, J.C., Verkhratsky, A., Weiss, C., Wiesel, T.N., Yaksi, E., Yizhar, O., Young, L.J., Young, P., Zawia, N.H., Zugaza, J.L. and Hasan, M.T.
Neuron 96
(4): 730-735.
15 November 2017
Microglia in physiology and disease.
Wolf, S.A., Boddeke, H.W.G.M. and Kettenmann, H.
Annual Review of Physiology 79
: 619-643.
February 2017
The role of microglia and macrophages in glioma maintenance and progression.
Hambardzumyan, D., Gutmann, D.H. and Kettenmann, H.
Nature Neuroscience 19
(1): 20-27.
January 2016
Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Hoffmann, C.J., Harms, U., Rex, A., Szulzewsky, F., Wolf, S.A., Grittner, U., Lättig-Tünnemann, G., Sendtner, M., Kettenmann, H., Dirnagl, U., Endres, M. and Harms, C.
Circulation 131
(20): 1772-1782.
19 May 2015
Microglia: new roles for the synaptic stripper.
Kettenmann, H., Kirchhoff, F. and Verkhratsky, A.
Neuron 77
(1): 10-18.
9 January 2013
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E.S.J., Wend, P., Purfürst, B., Nuber, U.A., Gurok, U., Matyash, V., Waelzlein, J.H., Chirasani, S.R., Dittmar, G., Cravatt, B.F., Momma, S., Lewin, G.R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H. and Glass, R.
Nature Medicine 18
(8): 1232-1238.
August 2012
Physiology of microglia.
Kettenmann, H., Hanisch, U.K., Noda, M. and Verkhratsky, A.
Physiological Reviews 91
(2): 461-553.
April 2011
Neuroglia: the 150 years after.
Kettenmann, H. and Verkhratsky, A.
Trends in Neurosciences 31
(12): 653-659.
December 2008
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
Rose, C., Ytrebo, L.M., Davies, N.A., Sen, S., Nedredal, G.I., Belanger, M., Revhaug, A. and Jalan, R.
Hepatology 46
(6): 1883-1892.
December 2007
Microglia: active sensor and versatile effector cells in the normal and pathologic brain.
Hanisch, U.K. and Kettenmann, H.
Nature Neuroscience 10
(11): 1387-1394.
November 2007
Neurotransmitter receptors on microglia.
Pocock, J.M. and Kettenmann, H.
Trends in Neurosciences 30
(10): 527-535.
October 2007
Neuroscience: The brain's garbage men.
Kettenmann, H.
Nature 446
(7139): 987-989.
26 April 2007
Triggering the brain's pathology sensor.
Kettenmann, H.
Nature Neuroscience 9
(12): 1463-1464.
December 2006
Neuronal or glial progeny: Regional differences in radial glia fate.
Malatesta, P., Hack, M.A., Hartfuss, E., Kettenmann, H., Klinkert, W., Kirchhoff, F. and Goetz, M.
Neuron 37
(5): 751-764.
6 March 2003
Exciting you: signals from another kingdom.
Schipke, C.G. and Spier, A.D.
Trends in Neurosciences 24
(12): 692.
1 December 2001
Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors?
van Rossum, D. and Hanisch, U.K.
Trends in Neurosciences 22
: 290-295.
1 July 1999
Glial calcium: Homeostasis and signaling function.
Verkhratsky, A., Orkand, R.K. and Kettenmann, H.
Physiological Reviews 78
(1): 99-141.
January 1998
Alexander von Humboldt and the concept of animal electricity.
Kettenmann, H.
Trends in Neurosciences 20
: 239-242.
1 January 1997
Na+/Ca2+ exchanger modulates kainate- triggered Ca2+ signaling in Bergmann glial cells in situ.
Kirischuk, S., Kettenmann, H. and Verkhratsky, A.
FASEB Journal 11
: 566-572.
1 January 1997
Calcium signalling in glial cells.
Verkhratsky, A. and Kettenmann, H.
Trends in Neurosciences 19
(8): 346-352.
1 August 1996
Beyond the neuronal circuitry.
Kettenmann, H.
Trends in Neurosciences 19
: 305-306.
1 January 1996
Interleukin-2 as a neuroregulatory cytokine.
Hanisch, U.K. and Quirion, R.
Brain Research Brain Research Reviews 21
: 246-284.
1 January 1995
Kettritz, Ralph (ECRC)
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83
(4): 499-507.
12 March 2024
Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132
(23): e160089.
1 December 2022
The Case: Is this hemolytic uremic syndrome?
Kettritz, R., Düttmann, W., Brand, A. and Luft, F.C.
Kidney International 102
(5): 1195-1196.
November 2022
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A., Sonnemann, J., Amann, K., Mildner, A., Lodka, D., Kling, L., Bieringer, M., Schneider, U., Leutz, A., Enghard, P., Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81
(8): 1162-1172.
August 2022
Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31
(7): 1569-1584.
July 2020
Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
Eulenberg-Gustavus, C., Bähring, S., Maass, P., Luft, F.C. and Kettritz, R.
Journal of Experimental Medicine 214
(7): 2089-2101.
3 July 2017
Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
Nickolas, T.L., Schmidt-Ott, K.M., Canetta, P., Forster, C., Singer, E., Sise, M., Elger, A., Maarouf, O., Sola-Del Valle, D.A., O'Rourke, M., Sherman, E., Lee, P., Geara, A., Imus, P., Guddati, A., Polland, A., Rahman, W., Elitok, S., Malik, N., Giglio, J., El-Sayegh, S., Devarajan, P., Hebbar, S., Saggi, S.J., Hahn, B., Kettritz, R., Luft, F.C. and Barasch, J.
Journal of the American College of Cardiology 59
(3): 246-255.
17 January 2012
BK channels in innate immune functions of neutrophils and macrophages.
Essin, K., Gollasch, M., Rolle, S., Weissgerber, P., Sausbier, M., Bohn, E., Autenrieth, I.B., Ruth, P., Luft, F.C., Nauseef, W.M. and Kettritz, R.
Blood 113
(6): 1326-1331.
5 February 2009
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
von Vietinghoff, S., Tunnemann, G., Eulenberg, C., Wellner, M., Cardoso, M.C., Luft, F.C. and Kettritz, R.
Blood 109
(10): 4487-4493.
15 May 2007
Pseudo-pseudo Meigs' syndrome.
Schmitt, R., Weichert, W., Schneider, W., Luft, F.C. and Kettritz, R.
Lancet 366
: 1672.
5 November 2005
Plasma exchange for primary autoimmune autonomic failure.
Schroeder, C., Vernino, S., Birkenfeld, A.L., Tank, J., Heusser, K., Lipp, A., Benter, T., Lindschau, C., Kettritz, R., Luft, F.C. and Jordan, J.
New England Journal of Medicine 353
(15): 1585-1590.
13 October 2005
Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M., Rolle, S., Wellner, M., Cardoso, M.C., Scheidereit, C., Luft, F.C. and Kettritz, R.
Blood 102
(6): 2259-2267.
15 September 2003
Kirwan, Jennifer (MDC/BIH)
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C., Thery, F., Wirth, E.K., Ochs, S., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A.
Cardiovascular Research 120
(6): 644-657.
6 April 2024
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15
(1): 2788.
30 March 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease.
Essex, M., Rios Rodriguez, V., Rademacher, J., Proft, F., Löber, U., Marko, L., Pleyer, U., Strowig, T., Marchand, J., Kirwan, J.A., Siegmund, B., Forslund, S.K. and Poddubnyy, D.
Arthritis & Rheumatology 76
(1): 48-58.
January 2024
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L., Frainay, C., Chazalviel, M., Cabanettes, F., Gloaguen, Y., Camenen, E., Merlet, B., Heux, S., Portais, J.C., Poupin, N., Vinson, F. and Jourdan, F.
Nucleic Acids Research 46
(W1): W495-W502.
2 July 2018
Klaassen, Sabine (ECRC)
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Arndt, A.K., Schaefer, S., Drenckhahn, J.D., Sabeh, M.K., Plovie, E.R., Caliebe, A., Klopocki, E., Musso, G., Werdich, A.A., Kalwa, H., Heinig, M., Padera, R.F., Wassilew, K., Bluhm, J., Harnack, C., Martitz, J., Barton, P.J., Greutmann, M., Berger, F., Huebner, N., Siebert, R., Kramer, H.H., Cook, S.A., Macrae, C.A. and Klaassen, S.
American Journal of Human Genetics 93
(1): 67-77.
11 July 2013
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Lincoln, S.E., Parrish, A.M., Dauksaite, V., Vakeel, P., Klaassen, S., Gerull, B., Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R., Perrot, A., Ozcelik, C., Saar, K., Hubner, N. and Gotthardt, M.
Nature Medicine 18
(5): 766-773.
May 2012
Mutations in sarcomere protein genes in left ventricular noncompaction.
Klaassen, S., Probst, S., Oechslin, E., Gerull, B., Krings, G., Schuler, P., Greutmann, M., Huerlimann, D., Yegitbasi, M., Pons, L., Gramlich, M., Drenckhahn, J.D., Heuser, A., Berger, F., Jenni, R. and Thierfelder, L.
Circulation 117
(22): 2893-2901.
3 June 2008
Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.
Heuser, A., Plovie, E.R., Ellinor, P.T., Grossmann, K.S., Shin, J.T., Wichter, T., Basson, C.T., Lerman, B.B., Sasse-Klaassen, S., Thierfelder, L., MacRae, C.A. and Gerull, B.
American Journal of Human Genetics 79
(6): 1081-1088.
December 2006
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S., Probst, S., Gerull, B., Oechslin, E., Nuernberg, P., Heuser, A., Jenni, R., Hennies, H.C. and Thierfelder, L.
Circulation 109
(22): 2720-2723.
8 June 2004
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Gerull, B., Gramlich, M., Atherton, J., McNabb, M., Trombitas, K., Sasse-Klaassen, S., Seidman, J.G., Seidman, C., Granzier, H., Labeit, S., Frenneaux, M. and Thierfelder, L.
Nature Genetics 30
(2): 201-204.
February 2002
Klussmann, Enno
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
Subramaniam, G., Schleicher, K., Kovanich, D., Zerio, A., Folkmanaite, M., Chao, Y.C., Surdo, N.C., Koschinski, A., Hu, J., Scholten, A., Heck, A.J.R, Ercu, M., Sholokh, A., Chan Park, K., Klussmann, E., Meraviglia, V., Bellin, M., Zanivan, S., Hester, S., Mohammed, S. and Zaccolo, M.
Circulation Research 132
(7): 828-848.
31 March 2023
Aquaporin-2 is not alone.
Klussmann, E.
Kidney International 103
(3): 458-460.
March 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R., Aronsen, J.M., Bergan-Dahl, A., Moutty, M.C., Lunde, M., Lunde, P.K., Jarstadmarken, H., Wanichawan, P., Pereira, L., Kolstad, T.R.S., Dalhus, B., Subramanian, H., Hille, S., Christensen, G., Müller, O.J., Nikolaev, V., Bers, D.M., Sjaastad, I., Shen, X., Louch, W.E., Klussmann, E. and Sejersted, O.M.
Circulation Research 130
(1): 27-44.
7 January 2022
Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M., Subramaniam, S., Chomsky-Hecht, O., Tsemakhovich, V., Flockerzi, V., Klussmann, E., Hirsch, J.A., Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118
(21): e2100021118.
17 May 2021
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C., Silva, R.L., Margaria, J.P., Pirali, T., Mattos, M.S., Kraemer, L.R., Reis, D.C., Grosa, G., Copperi, F., Dalmarco, E.M., Lima-Júnior, R.C.P., Aprile, S., Sala, V., Dal Bello, F., Prado, D.S., Alves-Filho, J.C., Medana, C., Cassali, G.D., Tron, G.C., Teixeira, M.M., Ciraolo, E., Russo, R.C. and Hirsch, E.
Nature Communications 9
(1): 5232.
12 December 2018
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47
(6): 647-653.
June 2015
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J.P., Cooper, D.M.F., Knapp, S., Rademann, J., Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52
(46): 12187-12191.
11 November 2013
Koehler, Matthias
Axoplasmic importins enable retrograde injury signaling in lesioned nerve.
Hanz, S., Perlson, E., Willis, D., Zheng, J.Q., Massarwa, R., Huerta, J.J., Koltzenburg, M., Koehler, M., van Minnen, J., Twiss, J.L. and Fainzilber, M.
Neuron 40
(6): 1095-1104.
18 December 2003
Krappmann, Daniel
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T.W., Ruland, J., Heissmeyer, V. and Krappmann, D.
Molecular Cell 23
(1): 13-23.
7 July 2006
Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., Heins, G., Ehrhardt, C. and Wolff, T.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13640-13645.
9 September 2005
Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196
(5): 605-617.
2 September 2002
Krause, Ernst-Georg
S100A1: A regulator of myocardial contractility.
Most, P., Bernotat, J., Ehlermann, P., Pleger, S.T., Reppel, M., Boerries, M., Niroomand, F., Pieske, B., Janssen, P.M.L., Eschenhagen, T., Karczewski, P., Smith, G.L., Koch, W.J.K., Katus, H.A. and Remppis, A.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13889-13894.
1 January 2001
Kudryashev, Mikhail
Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14
(1): 6543.
17 October 2023
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Faelber, K., Dietrich, L., Noel, J.K., Wollweber, F., Pfitzner, A.K., Mühleip, A., Sánchez, R., Kudryashev, M., Chiaruttini, N., Lilie, H., Schlegel, J., Rosenbaum, E., Hessenberger, M., Matthaeus, C., Kunz, S., von der Malsburg, A., Noé, F., Roux, A., van der Laan, M., Kühlbrandt, W. and Daumke, O.
Nature 571
(7765): 429-433.
18 July 2019
Kuehn, Ralf (MDC/BIH)
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T., Graf, R., Acevedo-Ochoa, E., Trombke, J., Weber, T., Sommermann, T., Salomon, C., Kühn, R., Rajewsky, K. and Chu, V.T.
Leukemia 38
(9): 2003-2015.
September 2024
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9
(92): eadi0042.
2 February 2024
A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M., Serve, S., Marx, A.F., Fadejeva, J., Saikali, P., Dzamukova, M., Durán-Hernández, N., Kommer, C., Heinrich, F., Durek, P., Heinz, G.A., Höfer, T., Mashreghi, M.F., Kühn, R., Pinschewer, D.D. and Löhning, M.
Nature Immunology 25
(2): 256-267.
February 2024
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24
(3): 414-422.
March 2023
In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C., Acemel, R.D., Jedamzick, J., Bolondi, A., Cova, G., Brieske, N., Kühn, R., Wittler, L., Real, F.M. and Lupiáñez, D.G.
Nature Genetics 54
(7): 1026-1036.
July 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K. and Chu, V.T.
Science Advances 8
(22): eabm9106.
3 June 2022
Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L.. and Löhning, M.
Nature Communications 13
(1): 3059.
1 June 2022
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T., Graf, R., Wulf-Goldenberg, A., Stecklum, M., Strauß, G., Kühn, R., Kocks, C., Rajewsky, K. and Chu, V.T.
Molecular Therapy 28
(12): 2621-2634.
2 December 2020
Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling, S.A., Fiedler, P., Lechner, M., Pollithy, A., Ehrenberg, S., Schiefer, A.I., Kenner, L., Feuchtinger, A., Kühn, R., Swinerd, G., Schmidt-Supprian, M., Strobl, L.J. and Zimber-Strobl, U.
Blood 133
(24): 2597-2609.
13 June 2019
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J., Rathkolb, B., Oestereicher, M.A., Schütt, C., Ravindranath, A.C., Leuchtenberger, S., Sharma, S., Kistler, M., Willershäuser, M., Brommage, R., Meehan, T.F., Mason, J., Haselimashhadi, H., Hough, T., Mallon, A.M., Wells, S., Santos, L., Lelliott, C.J., White, J.K., Sorg, T., Champy, M.F., Bower, L.R., Reynolds, C. L., Flenniken, A.M., Murray, St.A., Nutter, L.M.J., Svenson, K.L., West, D., Tocchini-Valentini, G.P., Beaudet, A.L., Bosch, F., Braun, R.B., Dobbie, M.S., Gao, X., Herault, Y., Moshiri, A., Moore, B.A., Kent Lloyd, K.C., McKerlie, C., Masuya, H., Tanaka, N., Flicek, P., Parkinson, H.E., Sedlacek, R., Seong, J.K., Wang, C.K.L., Moore, M., Brown, S.D., Tschöp, M.H., Wurst, W., Klingenspor, M., Wolf, E., Beckers, J., Machicao, F., Peter, A., Staiger, H., Häring, H.U., Grallert, H., Campillos, M., Maier, H., Fuchs, H., Gailus-Durner, V., Werner, T. and Hrabe de Angelis, M.
Nature Communications 9
(1): 288.
18 January 2018
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357
(6357): eaam8526.
22 September 2017
Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. and Chu, V.T.
Genome Biology 16
(1): 244.
10 November 2015
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K. and Kühn, R.
Nature Biotechnology 33
(5): 543-548.
May 2015
Kunz, Severine
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14
(1): 8043.
19 December 2023
Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. and Daumke, O.
Science Advances 8
(35): eabo4946.
2 September 2022
Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C., Dietert, K., Schotsaert, M., Martínez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M., Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S., Gruber, A.D., Hoetzenecker, W., Steinkellner, H., Purfuerst, B., Motz, R., Di Pierro, F., Lamprecht, B., Osterrieder, N., Landthaler, M., Drosten, C., García-Sastre, A., Langer, R., Ralser, M., Eils, R., Reimann, M., Fan, D.N.Y. and Schmitt, C.A.
Nature 599
: 283-289.
11 November 2021
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
Lacadie, Scott
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C, Daub, C.O., Lenhard, B. and Müller, F.
Nature Genetics 54
(7): 1037-1050.
July 2022
Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M., Karabacak, A., Glahs, A., Kolundzic, E., Hirsekorn, A., Carda, A., Tursun, B., Zinzen, R.P., Lacadie, S.A. and Ohler, U.
Nature Communications 9
(1): 4472.
26 October 2018
Redundant regulation.
Lacadie, S.A. and Ohler, U.
Nature Ecology & Evolution 2
(3): 418-419.
March 2018
Human promoters are intrinsically directional.
Duttke, S.H.C., Lacadie, S.A., Ibrahim, M.M., Glass, C.K., Corcoran, D.L., Benner, C., Heinz, S., Kadonaga, J.T. and Ohler, U.
Molecular Cell 57
(4): 674-684.
19 February 2015
NextGen speaks.
Lacadie, S.A.
Science 340
(6128): 29.
April 2013
Landthaler, Markus (BIMSB)
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E., Lauber, C., Manukyan, A., Deter, A., Quedenau, C., Teixeira Alves, L.G., Wylezich, C., Borodina, T., Seitz, S., Altmüller, J. and Landthaler, M.
Environment International 190
: 108875.
August 2024
Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E., Landthaler, M., Jung, K. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 35
(7): 838-853.
July 2024
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A., Plewka, J., Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A.N., Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova, Y., Minia, I., Mak, P., Landthaler, M., Nowotny, M., Dubin, G., Sattler, M., Suder, P., Popowicz, G.M., Pyrć, K. and Czarna, A.
Nucleic Acids Research 52
(11): 6441-6458.
24 June 2024
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J., Meinhardt, J., Aschman, T., Chua, R.L., Farztdinov, V., Lukassen, S., Ten, F.W., Friebel, E., Ishaque, N., Franz, J., Huhle, V.H., Mothes, R., Peters, K., Thomas, C., Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D., Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S., Horst, D., Kurth, F., Müller, M.A., Gassen, N.C., Melchert, J., Jechow, K., Timmermann, B., Fernandez-Zapata, C., Böttcher, C., Stenzel, W., Krüger, E., Landthaler, M., Wyler, E., Corman, V., Stadelmann, C., Ralser, M., Eils, R., Heppner, F.L., Mülleder, M., Conrad, C. and Radbruch, H.
Nature Neuroscience 27
(3): 409-420.
March 2024
Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
Uehata, T., Yamada, S., Ori, D., Vandenbon, A., Giladi, A., Jelinski, A., Murakawa, Y., Watanabe, H., Takeuchi, K., Toratani, K., Mino, T., Kiryu, H., Standley, D.M., Tsujimura, T., Ikawa, T., Kondoh, G., Landthaler, M., Kawamoto, H., Rodewald, H.R., Amit, I., Yamamoto, R., Miyazaki, M. and Takeuchi, O.
Blood 143
(3): 243-257.
18 January 2024
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8
(7): 1252-1266.
July 2023
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles, G., Adler, J.M., Pennitz, P., Peidli, S., Teixeira Alves, L.G., Baumgardt, M., Bushe, J., Voss, A., Langenhagen, A., Langner, C., Martin Vidal, R., Pott, F., Kazmierski, J., Ebenig, A., Lange, M.V., Mühlebach, M.D., Goekeri, C., Simmons, S., Xing, N., Abdelgawad, A., Herwig, S., Cichon, G., Niemeyer, D., Drosten, C., Goffinet, C., Landthaler, M., Blüthgen, N., Wu, H., Witzenrath, M., Gruber, A.D., Praktiknjo, S.D., Osterrieder, N., Wyler, E., Kunec, D. and Trimpert, J.
Nature Microbiology 8
(5): 860-874.
May 2023
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60
(6): 2102725.
1 December 2022
A critical period of translational control during brain development at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29
(12): 1277-1290.
December 2022
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, S., Hurdiss, D.L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N., Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D., Paladino, M., Schiegg, D., Mangold, S., Reichen, C., Radom, F., Kaufmann, Y., Schaible, D., Schlegel, I., Zitt, C., Sigrist, G., Straumann, M., Wolter, J., Comby, M., Sacarcelik, F., Drulyte, I., Lyoo, H., Wang, C., Li, W., Du, W., Binz, H.K., Herrup, R., Lusvarghi, S., Neerukonda, S.N., Vassell, R., Wang, W., Adler, J.M., Eschke, K., Nascimento, M., Abdelgawad, A., Gruber, A.D., Bushe, J., Kershaw, O., Knutson, C.G., Balavenkatraman, K.K., Ramanathan, K., Wyler, E., Teixeira Alves, L.G., Lewis, S., Watson, R., Haeuptle, M.A., Zürcher, A., Dawson, K.M., Steiner, D., Weiss, C.D., Amstutz, P., van Kuppeveld, F.J.M., Stumpp, M.T., Bosch, B.J., Engler, O. and Trimpert, J.
Nature Biotechnology 40
(12): 1845-1854.
December 2022
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27
(43): 2101089.
27 October 2022
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C.H., Müller, S., Mastrobuoni, G., Hazapis, O.G., Del Giudice, S., Schwefel, D., Bley, N., Voigt, F., Chao, J.A., Kempa, S., Hüttelmaier, S., Selbach, M. and Landthaler, M.
Nature Communications 13
(1): 2727.
18 May 2022
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler, E., Adler, J.M., Eschke, K., Teixeira Alves, G., Peidli, S., Pott, F., Kazmierski, J., Michalick, L., Kershaw, O., Bushe, J., Andreotti, S., Pennitz, P., Abdelgawad, A., Postmus, D., Goffinet, C., Kreye, J., Reincke, S.M., Prüss, H., Blüthgen, N., Gruber, A.D., Kuebler, W.M., Witzenrath, M., Landthaler, M., Nouailles, G. and Trimpert, J.
Molecular Therapy 30
(5): 1952-1965.
4 May 2022
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74
(6): 1039-1046.
15 March 2022
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D., Wyler, E., Landthaler, M., Obermayer, B., von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185
(3): 493-512.
3 February 2022
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I.L., Mittermaier, M., Mache, C., Chua, R.L., Knoll, R., Timm, S., Brumhard, S., Krammer, T., Zauber, H., Hiller, A.L., Pascual-Reguant, A., Mothes, R., Bülow, R.D., Schulze, J., Leipold, A.M., Djudjaj, S., Erhard, F., Geffers, R., Pott, F., Kazmierski, J., Radke, J., Pergantis, P., Baßler, K., Conrad, C., Aschenbrenner, A.C., Sawitzki, B., Landthaler, M., Wyler, E., Horst, D., Hippenstiel, S., Hocke, A., Heppner, F.L., Uhrig, A., Garcia, C., Machleidt, F., Herold, S., Elezkurtaj, S., Thibeault, C., Witzenrath, M., Cochain, C., Suttorp, N., Drosten, C., Goffinet, C., Kurth, F., Schultze, J.L., Radbruch, H., Ochs, M., Eils, R., Müller-Redetzky, H., Hauser, A.E., Luecken, M.D., Theis, F.J., Conrad, C., Wolff, T., Boor, P., Selbach, M., Saliba, A.E. and Sander, L.E.
Cell 184
(26): 6243-6261.
22 December 2021
Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F., Postmus, D., Brown, R.J.P., Wyler, E., Neumann, E., Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10
(1): 2151-2168.
16 November 2021
Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C., Dietert, K., Schotsaert, M., Martínez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M., Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S., Gruber, A.D., Hoetzenecker, W., Steinkellner, H., Purfuerst, B., Motz, R., Di Pierro, F., Lamprecht, B., Osterrieder, N., Landthaler, M., Drosten, C., García-Sastre, A., Langer, R., Ralser, M., Eils, R., Reimann, M., Fan, D.N.Y. and Schmitt, C.A.
Nature 599
: 283-289.
11 November 2021
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., Raabe, J., Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., Monin, M.B., Hoffmeister, C., Schlabe, S., De Domenico, E., Reusch, N., Händler, K., Reynolds, G., Blüthgen, N., Hack, G., Finnemann, C., Nischalke, H.D., Strassburg, C.P., Stephenson, E., Su, Y., Gardner, L., Yuan, D., Chen, D., Goldman, J., Rosenstiel, P., Schmidt, S.V., Latz, E., Hrusovsky, K., Ball, A.J., Johnson, J.M., Koenig, P.A., Schmidt, F.I., Haniffa, M., Heath, J.R., Kümmerer, B.M., Keitel, V., Jensen, B., Stubbemann, P., Kurth, F., Sander, L.E., Sawitzki, B., Aschenbrenner, A.C., Schultze, J.L. and Nattermann, J.
Immunity 54
(11): 2650-2669.
9 November 2021
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F., Bischoff, P., Peidli, S., Sieber, A., Trinks, A., Lüthen, M., Obermayer, B., Blanc, E., Ruchiy, Y., Sell, T., Mamlouk, S., Arsie, R., Wei, T.T., Klotz-Noack, K., Schwarz, R.F., Sawitzki, B., Kamphues, C., Beule, D., Landthaler, M., Sers, C., Horst, D., Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13
(10): e14123.
7 October 2021
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G., Wyler, E., Pennitz, P., Postmus, D., Vladimirova, D., Kazmierski, J., Pott, F., Dietert, K., Muelleder, M., Farztdinov, V., Obermayer, B., Wienhold, S.M., Andreotti, S., Hoefler, T., Sawitzki, B., Drosten, C., Sander, L.E., Suttorp, N., Ralser, M., Beule, D., Gruber, A.D., Goffinet, C., Landthaler, M., Trimpert, J. and Witzenrath, M.
Nature Communications 12
(1): 4869.
11 August 2021
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C., Papies, J., Bajaj, T., Emanuel, J., Dethloff, F., Chua, R.L., Trimpert, J., Heinemann, N., Niemeyer, C., Weege, F., Hönzke, K., Aschman, T., Heinz, D.E., Weckmann, K., Ebert, T., Zellner, A., Lennarz, M., Wyler, E., Schroeder, S., Richter, A., Niemeyer, D., Hoffmann, K., Meyer, T.F., Heppner, F.L., Corman, V.M., Landthaler, M., Hocke, A.C., Morkel, M., Osterrieder, N., Conrad, C., Eils, R., Radbruch, H., Giavalisco, P., Drosten, C. and Müller, M.A.
Nature Communications 12
(1): 3818.
21 June 2021
Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S., Schultze, H., Shastry, K.L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N.A., Ktena, S., Tran, F., Bitzer, M., Ossowski, S., Casadei, N., Herr, C., Petersheim, D., Behrends, U., Kern, F., Fehlmann, T., Schommers, P., Lehmann, C., Augustin, M., Rybniker, J., Altmüller, J., Mishra, N., Bernardes, J.P., Krämer, B., Bonaguro, L., Schulte-Schrepping, J., De Domenico, E., Siever, C., Kraut, M., Desai, M., Monnet, B., Saridaki, M., Siegel, C.M., Drews, A., Nuesch-Germano, M., Theis, H., Heyckendorf, J., Schreiber, S., Kim-Hellmuth, S., Nattermann, J., Skowasch, D., Kurth, I., Keller, A., Bals, R., Nürnberg, P., Rieß, O., Rosenstiel, P., Netea, M.G., Theis, F., Mukherjee, S., Backes, M., Aschenbrenner, A.C., Ulas, T., Breteler, M.M.B., Giamarellos-Bourboulis, E.J., Kox, M., Becker, M., Cheran, S., Woodacre, M.S., Goh, E.L. and Schultze, J.L.
Nature 594
(7862): 265-270.
10 June 2021
Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M. and Junker, J.P.
Nature Communications 12
: 3358.
7 June 2021
DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L., Venkataramanan, S., Rogowski, K.J., Wyler, E., Wilkins, K., Tejura, M., Thai, B., Krol, J., Filipowicz, W., Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49
(9): 5336-5350.
May 2021
Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L., Krupp, F., Harnett, D., Turko, P., Ambrozkiewicz, M.C., Sprink, T., Imami, K., Günnigmann, M., Zinnall, U., Vieira-Vieira, C.H., Schaub, T., Münster-Wandowski, A., Bürger, J., Borisova, E., Yamamoto, H., Rasin, M.R., Ohler, U., Beule, D., Mielke, T., Tarabykin, V., Landthaler, M., Kramer, G., Vida, I., Selbach, M. and Spahn, C.M.T.
Molecular Cell 81
(2): 304-322.
21 January 2021
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., Baßler, K., Saridaki, M., Knoll, R., Pecht, T., Kapellos, T.S., Doulou, S., Kröger, C., Herbert, M., Holsten, L., Horne, A., Gemünd, I.D., Rovina, N., Agrawal, S., Dahm, K., van Uelft, M., Drews, A., Lenkeit, L., Bruse, N., Gerretsen, J., Gierlich, J., Becker, M., Händler, K., Kraut, M., Theis, H., Mengiste, S., Domenico, E., Schulte-Schrepping, J., Seep, L., Raabe, J., Hoffmeister, C., ToVinh, M., Keitel, V., Rieke, G., Talevi, V., Skowasch, D., Aziz, N.A., Pickkers, P., van de Veerdonk, F.L., Netea, M.G., Schultze, J.L., Kox, M., Breteler, M.M.B., Nattermann, J., Koutsoukou, A., Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13
(1): 7.
13 January 2021
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P., Mishra, N., Tran, F., Bahmer, T., Best, L., Blase, J.I., Bordoni, D., Franzenburg, J., Geisen, U., Josephs-Spaulding, J., Köhler, P., Künstner, A., Rosati, E., Aschenbrenner, A.C., Bacher, P., Baran, N., Boysen, T., Brandt, B., Bruse, N., Dörr, J., Dräger, A., Elke, G., Ellinghaus, D., Fischer, J., Forster, M., Franke, A., Franzenburg, S., Frey, N., Friedrichs, A., Fuß, J., Glück, A., Hamm, J., Hinrichsen, F., Hoeppner, M.P., Imm, S., Junker, R., Kaiser, S., Kan, Y.H., Knoll, R., Lange, C., Laue, G., Lier, C., Lindner, M., Marinos, G., Markewitz, R., Nattermann, J., Noth, R., Pickkers, P., Rabe, K.F., Renz, A., Röcken, C., Rupp, J., Schaffarzyk, A., Scheffold, A., Schulte-Schrepping, J., Schunk, D., Skowasch, D., Ulas, T., Wandinger, K.P., Wittig, M., Zimmermann, J., Busch, H., Hoyer, B.F., Kaleta, C., Heyckendorf, J., Kox, M., Rybniker, J., Schreiber, S., Schultze, J.L. and Rosenstiel, P.
Immunity 53
(6): 1296-1314.
15 December 2020
Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., De Domenico, E., Wendisch, Da., Grasshoff, M., Kapellos, T.S., Beckstette, M., Pecht, T., Saglam, A., Dietrich, O., Mei, H.E., Schulz, A.R., Conrad, C., Kunkel, D., Vafadarnejad, E., Xu, C.J., Horne, A., Herbert, M., Drews, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., Müller-Redetzky, H., Heim, K.M., Machleidt, F., Uhrig, A., Bosquillon de Jarcy, L., Jürgens, L., Stegemann, M., Glösenkamp, C.R., Volk, H.D., Goffinet, C., Landthaler, M., Wyler, E., Georg, P., Schneider, M., Dang-Heine, C., Neuwinger, N., Kappert, K., Tauber, R., Corman, V., Raabe, J., Kaiser, K.M., Vinh, M.T., Rieke, G., Meisel, C., Ulas, T., Becker, M., Geffers, R., Witzenrath, M., Drosten, C., Suttorp, N., von Kalle, C., Kurth, F., Händler, K., Schultze, J.L., Aschenbrenner, A.C., Li, Y., Nattermann, J., Sawitzki, B., Saliba, A.E. and Sander, L.E.
Cell 182
(6): 1419-1440.
17 September 2020
Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W., Jürges, C.S., Hennig, T., Wyler, E., Prusty, B., Rutkowski, A.J., L'hernault, A., Djakovic, L., Göbel, M., Döring, K., Menegatti, J., Antrobus, R., Matheson, N.J., Künzig, F.W.H., Mastrobuoni, G., Bielow, C., Kempa, S., Liang, C., Dandekar, T., Zimmer, R., Landthaler, M., Grässer, F., Lehner, P.J., Friedel, C.C., Erhard, F. and Dölken, L.
Nature Communications 11
(1): 2038.
27 April 2020
The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T., Schmid, M., Dou, Y., Garland, W., Milek, M., Imami, K., Johnsen, D., Polak, P., Andersen, J.S., Selbach, M., Landthaler, M. and Jensen, T.
Nucleic Acids Research 48
(5): 2518-2530.
18 March 2020
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E., Franke, V., Menegatti, J., Kocks, C., Boltengagen, A., Praktiknjo, S., Walch-Rückheim, B., Bosse, J., Rajewsky, N., Grässer, F., Akalin, A. and Landthaler, M.
Nature Communications 10
(1): 4878.
25 October 2019
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K., Milek, M., Bogdanow, B., Yasuda, T., Kastelic, N., Zauber, H., Ishihama, Y., Landthaler, M. and Selbach, M.
Molecular Cell 72
(1): 84-98.
4 October 2018
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E., Menegatti, J., Franke, V., Kocks, C., Boltengagen, A., Hennig, T., Theil, K., Rutkowski, A., Ferrai, C., Baer, L., Kermas, L., Friedel, C., Rajewsky, N., Akalin, A., Dölken, L., Grässer, F. and Landthaler, M.
Genome Biology 18
(1): 209.
31 October 2017
DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M., Imami, K., Mukherjee, N., De Bortoli, F., Zinnall, U., Hazapis, O., Trahan, C., Oeffinger, M., Heyd, F., Ohler, U., Selbach, M. and Landthaler, M.
Genome Research 27
(8): 1344-1359.
August 2017
Translation of circRNAs.
Pamudurti, N.R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., Shenzis, S., Samson, M., Dittmar, G., Landthaler, M., Chekulaeva, M., Rajewsky, N. and Kadener, S.
Molecular Cell 66
(1): 9-21.
6 April 2017
Eyes on translation.
Chekulaeva, M. and Landthaler, M.
Molecular Cell 63
(6): 918-925.
15 September 2016
The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway.
Hasler, D., Lehmann, G., Murakawa, Y., Klironomos, F., Jakob, L., Grässer, F.A., Rajewsky, N., Landthaler, M. and Meister, G.
Molecular Cell 63
(1): 110-124.
7 July 2016
The mRNA-bound proteome of the early fly embryo.
Wessels, H.H., Imami, K., Baltz, A.G., Kolinski, M., Beldovskaya, A., Selbach, M., Small, S., Ohler, U. and Landthaler, M.
Genome Research 26
(7): 1000-1009.
July 2016
Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L., Mukherjee, N., Wyler, E., Zauber, H., Hirsekorn, A., Selbach, M., Landthaler, M., Obermayer, B. and Ohler, U.
Nature Methods 13
(2): 165-170.
February 2016
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.
Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H.H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., Vinuesa, C.G., Ohler, U., Standley, D.M., Landthaler, M., Fujiwara, T. and Takeuchi, O.
Cell 161
(5): 1058-1073.
21 May 2015
Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M. and Heinemann, U.
Nature Communications 5
: 5701.
11 December 2014
A variety of dicer substrates in human and C. elegans.
Rybak-Wolf, A., Jens, M., Murakawa, Y., Herzog, M., Landthaler, M. and Rajewsky, N.
Cell 159
(5): 1153-1167.
20 November 2014
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124
(8): 3419-3430.
1 August 2014
MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H., Schueler, M., Munschauer, M., Mastrobuoni, G., Chen, W., Kempa, S., Dieterich, C. and Landthaler, M.
Molecular Cell 54
(4): 573-585.
22 May 2014
Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M., Munschauer, M., Gregersen, L.H., Finzel, A., Loewer, A., Chen, W., Landthaler, M. and Dieterich, C.
Genome Biology 15
(1): R15.
13 January 2014
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495
(7441): 333-338.
21 March 2013
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G., Munschauer, M., Schwanhaeusser, B., Vasile, A., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., Wyler, E., Bonneau, R., Selbach, M., Dieterich, C. and Landthaler, M.
Molecular Cell 46
(5): 674-690.
8 June 2012
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Lebedeva, S., Jens, M., Theil, K., Schwanhaeusser, B., Selbach, M., Landthaler, M. and Rajewsky, N.
Molecular Cell 43
(3): 340-352.
5 August 2011
Chaperones get RISC loaded.
Landthaler, M.
Molecular Cell 39
(2): 161-162.
30 July 2010
Le Noble, Ferdinand
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Lee, S., Hannappel, E., Bock-Marquette, I., Theisen, D., Leitner, L., Boekstegers, P., Cierniewski, C., Mueller, O.J., le Noble, F., Adams, R.H., Weinl, C., Nordheim, A., Reichart, B., Weber, C., Olson, E., Posern, G., Deindl, E., Niemann, H. and Kupatt, C.
Nature Communications 5
: 3970.
9 June 2014
Bone biology: vessels of rejuvenation.
le Noble, F. and le Noble, J.
Nature 507
(7492): 313-314.
20 March 2014
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495
(7441): 333-338.
21 March 2013
Extrinsic notch ligand delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Napp, L.C., Augustynik, M., Paesler, F., Krishnasamy, K., Woiterski, J., Limbourg, A., Bauersachs, J., Drexler, H., le Noble, F. and Limbourg, F.P.
Circulation Research 110
(4): 530-550.
17 February 2012
The shunt problem: control of functional shunting in normal and tumour vasculature.
Pries, A.R., Hoepfner, M., le Noble, F., Dewhirst, M.W. and Secomb, T.W.
Nature Reviews Cancer 10
(8): 587-593.
August 2010
Fetal growth restriction results in remodeled and less efficient hearts in children.
Crispi, F., Bijnens, B., Figueras, F., Bartrons, J., Eixarch, E., le Noble, F., Ahmed, A. and Gratacos, E.
Circulation 121
(22): 2427-2436.
8 June 2010
Lee, Young-Ae (MDC/ECRC)
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M.K., Shringarpure, S.S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B.M., Thomas, L.F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J.V.T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A., Jeong, A., Fawcett, K.A., Baurecht, H., Rodriguez, E., Alves, A.C., Kumar, A., Sleiman, P.M., Chang, X., Medina-Gomez, C., Hu, C., Xu, C.J., Qi, C., El-Heis, S., Titcombe, P., Antoun, E., Fadista, J., Wang, C.A., Thiering, E., Wu, B., Kress, S., Kothalawala, D.M., Kadalayil, L., Duan, J., Zhang, H., Hadebe, S., Hoffmann, T., Jorgenson, E., Choquet, H., Risch, N., Njølstad, P., Andreassen, O.A., Johansson, S., Almqvist, C., Gong, T., Ullemar, V., Karlsson, R., Magnusson, P.K.E., Szwajda, A., Burchard, E.G., Thyssen, J.P., Hansen, T., Kårhus, L.L., Dantoft, T.M., Jeanrenaud, A.C.S.N., Ghauri, A., Arnold, A., Homuth, G., Lau, S., Nöthen, M.M., Hübner, N., Imboden, M., Visconti, A., Falchi, M., Bataille, V., Hysi, P., Ballardini, N., Boomsma, D.I., Hottenga, J.J., Müller-Nurasyid, M., Ahluwalia, T.S., Stokholm, J., Chawes, B., Schoos, A.M.M., Esplugues, A., Bustamante, M., Raby, B., Arshad, S., German, C., Esko, T., Milani, L.A., Metspalu, A., Terao, C., Abuabara, K., Løset, M., Hveem, K., Jacobsson, B., Pino-Yanes, M., Strachan, D.P., Grarup, N., Linneberg, A., Lee, Y., Probst-Hensch, N., Weidinger, S., Jarvelin, M.R., Melén, E., Hakonarson, H., Irvine, A.D., Jarvis, D., Nijsten, T., Duijts, L., Vonk, J.M., Koppelmann, G.H., Godfrey, K.M., Barton, S.J., Feenstra, B., Pennell, C.E., Sly, P.D., Holt, P.G., Williams, L.K., Bisgaard, H., Bønnelykke, K., Curtin, J., Simpson, A., Murray, C., Schikowski, T., Bunyavanich, S., Weiss, S.T., Holloway, J.W., Min, J.L., Brown, S.J., Standl, M. and Paternoster, L.
Nature Communications 14
(1): 6172.
4 October 2023
Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B., Marenholz, I., Jeanrenaud, A.C.S.N., Meixner, L., Arnau-Soler, A., Rosillo-Salazar, O.D., Ghauri, A., Cibin, P., Blümchen, K., Schlags, R., Hansen, G., Seidenberg, J., Keil, T., Lau, S., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 150
(5): 1125-1134.
November 2022
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D., Lindberg, E.L., Maatz, H., Miranda, A.M.A., Viveiros, A., Shvetsov, N., Gärtner, A., Nadelmann, E.R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D.M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J.M., Barnett, S.N., Brown, K., Buchan, R.J., Chowdhury, R.A., Constantinou, C., Cranley, J., Felkin, L.E., Fox, H., Ghauri, A., Gummert, J., Kanda, M., Li, R., Mach, L., McDonough, B., Samari, S., Shahriaran, F., Yapp, C., Stanasiuk, C., Theotokis, P.I., Theis, F.J., van den Bogaerdt, A., Wakimoto, H., Ware, J.S., Worth, C.L., Barton, P.J.R., Lee, Y.A., Teichmann, S.A., Milting, H., Noseda, M., Oudit, G.Y., Heinig, M., Seidman, J.G., Hubner, N. and Seidman, C.E.
Science 377
(6606): eabo1984.
5 August 2022
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S., Marenholz, I., Esparza-Gordillo, J., Arnau-Soler, A., Pairo-Castineira, E., Rüschendorf, F., Ahluwalia, T.S., Almqvist, C., Arnold, A., Baurecht, H., Bisgaard, H., Bønnelykke, K., Brown, S.J., Bustamante, M., Curtin, J.A., Custovic, A., Dharmage, S.C., Esplugues, A., Falchi, M., Fernandez-Orth, D., Ferreira, M.A.R., Franke, A., Gerdes, S., Gieger, C., Hakonarson, H., Holt, P.G., Homuth, G., Hubner, N., Hysi, P.G., Jarvelin, M.R., Karlsson, R., Koppelman, G.H., Lau, S., Lutz, M., Magnusson, P.K.E., Marks, G.B., Müller-Nurasyid, M., Nöthen, M.M., Paternoster, L., Pennell, C.E., Peters, A., Rawlik, K., Robertson, C.F., Rodriguez, E., Sebert, S., Simpson, A., Sleiman, P.M.A., Standl, M., Stölzl, D., Strauch, K., Szwajda, A., Tenesa, A., Thompson, P.J., Ullemar, V., Visconti, A., Vonk, J.M., Wang, C.A., Weidinger, S., Wielscher, M., Sargent, C.L., Xu, C.J. and Lee, Y.A.
Nature Communications 12
(1): 6618.
16 November 2021
Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis.
Thyssen, J.P., Ahluwalia, T.S., Paternoster, L., Ballardini, N., Bergström, A., Melén, E., Chawes, B., Stokholm, J., Hourihane, J.O., O'Sullivan, D.M., Bager, P., Maelbye, M., Bustamante, M., Torrent, M., Esplugues, A., Duijts, L., Hu, C., Elbert, N.J., Pasmans, S.G.M.A., Nijsten, T.E C., von Berg, A., Standl, M., Schikowski, T., Herberth, G., Heinrich, J., Lee, Y.A., Marenholz, I., Lau, S., Curtin, J.A., Simpson, A., Custovic, A., Pennell, C.E., Wang, C.A., Holt, P.G., Bisgaard, H. and Bønnelykke, K.
Allergy 75
(6): 1481-1485.
June 2020
Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy.
Asai, Y., Martino, D., Eiwegger, T., Nadeau, K., Koppelman, G.H., Clarke, A.E., Lee, Y.A., Chan, E.S., Simons, E., Laprise, C., Mazer, B., Marenholz, I., Royce, D., Elliott, S.J., Hampson, C., Gerdts, J., Eslami, A., Soller, L., Hui, J., Azad, M., Sandford, A. and Daley, D.
Allergy 75
(9): 2383-2387.
23 April 2020
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha, S., Baurecht, H., Novak, N., Rodríguez, E., Bej, S., Mayr, G., Emmert, H., Stölzl, D., Gerdes, S., Degenhardt, F., Hübenthal, M., Ellinghaus, E., Jung, E.S., Kässens, J.C., Wienbrandt, L., Lieb, W., Müller-Nurasyid, M., Hotze, M., Dand, N., Grosche, S., Marenholz, I., Arnold, A., Homuth, G., Schmidt, C.O., Wehkamp, U., Nöthen, M.M., Hoffmann, P., Paternoster, L., Standl, M., Bønnelykke, K., Ahluwalia, T.S., Bisgaard, H., Peters, A., Gieger, C., Waldenberger, M., Schulz, H., Strauch, K., Werfel, T., Lee, Y.A., Wolfien, M., Rosenstiel, P., Wolkenhauer, O., Schreiber, St., Franke, A., Weidinger, S. and Ellinghaus, D.
Journal of Allergy and Clinical Immunology 145
(4): 1208-1218.
April 2020
Eleven loci with new reproducible genetic associations with allergic disease risk.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Rüschendorf, F., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Karlsson, R., Almqvist, C., Koppelman, G.H. and Paternoster, L.
Journal of Allergy and Clinical Immunology 143
(2): 691-699.
February 2019
Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study.
Marenholz, I., Grosche, S., Rüschendorf, F., Kalb, B., Blumchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Yürek, S., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hubner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 142
(4): 1368-1370.
October 2018
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage, J., Standl, M., Curtin, J.A., Jessen, L.E., Thorsen, J., Tian, C., Schoettler, N., Flores, C., Abdellaoui, A., Ahluwalia, T.S., Alves, A.C., Amaral, A.F.S., Antó, J.M., Arnold, A., Barreto-Luis, A., Baurecht, H., van Beijsterveldt, C.E.M., Bleecker, E.R., Bonàs-Guarch, S., Boomsma, D.I., Brix, S., Bunyavanich, S., Burchard, E.G., Chen, Z., Curjuric, I., Custovic, A., den Dekker, H.T., Dharmage, S.C., Dmitrieva, J., Duijts, L., Ege, M.J., Gauderman, W.J., Georges, M., Gieger, C., Gilliland, F., Granell, R., Gui, H., Hansen, T., Heinrich, J., Henderson, J., Hernandez-Pacheco, N., Holt, P., Imboden, M., Jaddoe, V.W.V., Jarvelin, M.R., Jarvis, D.L., Jensen, K.K., Jónsdóttir, I., Kabesch, M., Kaprio, J., Kumar, A., Lee, Y.A., Levin, A.M., Li, X., Lorenzo-Diaz, F., Melén, E., Mercader, J.M., Meyers, D.A., Myers, R., Nicolae, D.L., Nohr, E.A., Palviainen, T., Paternoster, L., Pennell, C.E., Pershagen, G., Pino-Yanes, M., Probst-Hensch, N.M., Rüschendorf, F., Simpson, A., Stefansson, K., Sunyer, J., Sveinbjornsson, G., Thiering, E., Thompson, P.J., Torrent, M., Torrents, D., Tung, J.Y., Wang, C.A., Weidinger, S., Weiss, S., Willemsen, G., Williams, L.K., Ober, C., Hinds, D.A., Ferreira, M.A., Bisgaard, H., Strachan, D.P. and Bønnelykke, K.
Nature Genetics 50
(8): 1072-1080.
August 2018
A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y., Eslami, A., van Ginkel, C.D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M.A., Allen, K., Mazer, B., de Groot, H., de Jong, N.W., Gerth van Wijk, R., Dubois, A.E.J., Grosche, S., Ashley, S., Rüschendorf, F., Kalb, B., Beyer, K., Nöthen, M.M., Lee, Y.A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J.S., Melles, R.B., Hong, X., Wang, X., Hui, J., Musk, A.W.B., Hunter, M., James, A.L., Koppelman, G.H., Sandford, A.J., Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141
(4): 1513-1516.
April 2018
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F., Margaritte-Jeannin, P., Barnes, K.C., Cookson, W.O.C., Altmüller, J., Ang, W., Barr, R.G., Beaty, T.H., Becker, A.B., Beilby, J., Bisgaard, H., Bjornsdottir, U.S., Bleecker, E., Bonnelykke, K., Boomsma, D.I., Bouzigon, E., Brightling, C.E., Brossard, M., Brusselle, G.G., Burchard, E., Burkart, K.M., Bush, A., Chan-Yeung, M., Chung, K.F., Couto Alves, A., Curtin, J.A., Custovic, A., Daley, D., de Jongste, J.C., Del-Rio-Navarro, B.E., Donohue, K.M., Duijts, L., Eng, C., Eriksson, J.G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M.A., Freidin, M.B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S.A, Gilliland, F., Granell, R., Graves, P.E., Gudbjartsson, D.F., Haahtela, T., Heckbert, S.R., Heederik, D., Heinrich, J., Helioevaara, M., Henderson, J., Himes, B.E., Hirose, H., Hirschhorn, J.N., Hofman, A., Holt, P., Hottenga, J., Hudson, T.J., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V.W.V., James, A., Janson, C., Jarvelin, M.R., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kähönen, M., Kantor, D.B., Karunas, A.S., Khusnutdinova, E., Koppelman, G.H., Kozyrskyj, A.L., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y.A., Lehtimaeki, T., Letort, S., Levin, A.M., Li, G., Liang, L., Loehr, L.R., London, S.J., Loth, D.W., Manichaikul, A., Marenholz, I., Martinez, F.J., Matheson, M.C., Mathias, R.A., Matsumoto, K., Mbarek, H., McArdle, W.L., Melbye, M., Melen, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A.W., Myers, R.A., Nieuwenhuis, M.A.E., Noguchi, E., O'Connor, G.T., Ogorodova, L.M., Palmer, C.D., Palotie, A., Park, J.E., Pennell, C.E., Pershagen, G., Polonikov, A., Postma, D.S., Probst-Hensch, N., Puzyrev, V.P., Raby, B.A., Raitakari, O.T., Ramasamy, A., Rich, S.S., Robertson, C.F., Romieu, I., Salam, M.T., Salomaa, V., Schluenssen, V., Scott, R., Selivanova, P.A., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L.J., Solodilova, M., Standl, M., Stefansson, K., Strachan, D.P., Stricker, B.H., Takahashi, A., Thompson, P.J., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C.M.T., Torgerson, D.G., Tsunoda, T., Uitterlinden, A.G., van der Valk, R.J.P., Vaysse, A., Vedantam, S., von Berg, A., von Mutius, E., Vonk, J.M., Waage, J., Wareham, N.J., Weiss, S.T., White, W.B., Wickman, M., Widén, E., Willemsen, G., Williams, L.K., Wouters, I.M., Yang, J.J., Zhao, J.H., Moffatt, M.F., Ober, C. and Nicolae, D.L.
Nature Genetics 50
(1): 42-53.
January 2018
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Yi, Rueschendorf, F., Esparza-Gordillo, J., Medway, C.W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B.M., Witte, J.S., Hottenga, J.J., Willemsen, G., Zheng, J., Rodriguez, E., Hotze, M., Franke, A., Revez, J.A., Beesley, J., Matheson, M.C., Dharmage, S.C., Bain, L.M., Fritsche, L.G., Gabrielsen, M.E., Balliu, B., Nielsen, J.B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O.L., Løset, M., Abecasis, G.R., Willer, C.J., Arnold, A., Homuth, G., Schmidt, C.O., Thompson, P.J., Martin, N.G., Duffy, D.L., Novak, N., Schulz, H., Karrasch, S., Gieger, C., Strauch, K., Melles, R.B., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K.E., Jansen, R., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Almqvist, C., Karlsson, R., Koppelman, G.H. and Paternoster, L.
Nature Genetics 49
(12): 1752-1757.
December 2017
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Röblitz, H., Yürek, S., Tschirner, S., Hong, X., Wang, X., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hübner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Nature Communications 8
(1): 1056.
20 October 2017
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.
Sarnowski, C., Laprise, C., Malerba, G., Moffatt, M.F., Dizier, M.H., Morin, A., Vincent, Q.B., Rohde, K., Esparza-Gordillo, J., Margaritte-Jeannin, P., Liang, L., Lee, Y.A., Bousquet, J., Siroux, V., Pignatti, P.F., Cookson, W.O., Lathrop, M., Pastinen, T., Demenais, F. and Bouzigon, E.
Journal of Allergy and Clinical Immunology 138
(3): 748-753.
September 2016
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y.A.E., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nöthen, M.M., Irvine, A.D., McLean, W.H.I., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N. and Weidinger, S.
Journal of Allergy and Clinical Immunology 137
(1): 130-136.
January 2016
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O'Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.R., Noethen, M.M., Lau, S., Hübner, N., Lee, Y.A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M. and Weidinger, S.
Nature Genetics 47
(12): 1449-1456.
December 2015
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I., Esparza-Gordillo, J., Rüschendorf, F., Bauerfeind, A., Strachan, D.P., Spycher, B.D., Baurecht, H., Margaritte-Jeannin, P., Sääf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M.C., Li, J., Michel, S., Ang, W.Q., McArdle, W., Arnold, A., Homuth, G., Demenais, F., Bouzigon, E., Söderhäll, C., Pershagen, G., de Jongste, J.C., Postma, D.S., Braun-Fahrlaender, C., Horak, E., Ogorodova, L.M., Puzyrev, V.P., Bragina, E.Y., Hudson, T.J., Morin, C., Duffy, D.L., Marks, G.B., Robertson, C.F., Montgomery, G.W., Musk, B., Thompson, P.J., Martin, N.G., James, A., Sleiman, P., Toskala, E., Rodriguez, E., Fölster-Holst, R., Franke, A., Lieb, W., Gieger, C., Heinzmann, A., Rietschel, E., Keil, T., Cichon, S., Nöthen, M.M., Pennell, C.E., Sly, P.D., Schmidt, C.O., Matanovic, A., Schneider, V., Heinig, M., Hübner, N., Holt, P.G., Lau, S., Kabesch, M., Weidinger, S., Hakonarson, H., Ferreira, M.A.R., Laprise, C., Freidin, M.B., Genuneit, J., Koppelman, G.H., Melén, E., Dizier, M.H., Henderson, A.J. and Lee, Y.A.
Nature Communications 6
: 8804.
6 November 2015
Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years.
Grabenhenrich, L.B., Keil, T., Reich, A., Gough, H., Beschorner, J., Hoffmann, U., Bauer, C.P., Forster, J., Schuster, A., Schramm, D., Nitsche, O., Zepp, F., Lee, Y.A., Bergmann, R., Bergmann, K., Wahn, U. and Lau, S.
Journal of Allergy and Clinical Immunology 136
(4): 932-940.
October 2015
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.
Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.J., Xiao, F.L., Lee, Y.A., Franke, A. and Weidinger, S.
Journal of Allergy and Clinical Immunology 136
(3): 802-806.
September 2015
eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.
Huang, J., Chen, J., Esparza, J., Ding, J., Elder, J.T., Abecasis, G.R., Lee, Y.A., Lathrop, G.M., Moffatt, M.F., Cookson, W.O.C. and Liang, L.
Nature Communications 6
: 6821.
8 May 2015
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O'Regan, G.M., Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J. and Brown, S.J.
American Journal of Human Genetics 96
(1): 104-120.
8 January 2015
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C., Kind, B., Reijns, M.A.M., Berndt, N., Martinez-Bueno, M., Wolf, C., Tüngler, V., Chara, O., Lee, Y.A., Hübner, N., Bicknell, L., Blum, S., Krug, C., Schmidt, F., Kretschmer, S., Koss, S., Astell, K.R., Ramantani, G., Bauerfeind, A., Morris, D.L., Cunninghame Graham, D.S., Bubeck, D., Leitch, A., Ralston, S.H., Blackburn, E.A., Gahr, M., Witte, T., Vyse, T.J., Melchers, I., Mangold, E., Nöthen, M.M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J.D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M.E., Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125
(1): 413-424.
2 January 2015
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.
Scholtens, S., Postma, D.S., Moffatt, M.F., Panasevich, S., Granell, R., Henderson, A.J., Melen, E., Nyberg, F., Pershagen, G., Jarvis, D., Ramasamy, A., Wjst, M., Svanes, C., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., von Mutius, E., Ege, M.J., Braun-Fahrlaender, C., Genuneit, J., Brunekreef, B., Smit, H.A., Wijga, A.H., Kerkhof, M., Curjuric, I., Imboden, M., Thun, G.A., Probst-Hensch, N., Freidin, M.B., Bragina, E.I., Deev, I.A., Puzyrev, V.P., Daley, D., Park, J., Becker, A., Chan-Yeung, M., Kozyrskyj, A.L., Pare, P., Marenholz, I., Lau, S., Keil, T., Lee, Y.A., Kabesch, M., Wijmenga, C., Franke, L., Nolte, I.M., Vonk, J., Kumar, A., Farrall, M., Cookson, W.O.C.M., Strachan, D.P., Koppelman, G.H. and Boezen, H.M.
Journal of Allergy and Clinical Immunology 133
(3): 885-888.
March 2014
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Saunders, S.P., Goh, C.S.M., Brown, S.J., Palmer, C.N.A., Porter, R.M., Cole, C., Campbell, L.E., Gierlinski, M., Barton, G.J., Schneider, G., Balmain, A., Prescott, A.R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y.A., Tavendale, R., Mukhopadhyay, S., Turner, S.W., Madhok, V.B., Sullivan, F.M., Relton, C., Burn, J., Meggitt, S., Smith, C.H., Allen, M.A., Barker, J.N.W.N., Reynolds, N.J., Cordell, H.J., Irvine, A.D., McLean, W.H.I., Sandilands, A. and Fallon, P.G.
Journal of Allergy and Clinical Immunology 132
(5): 1121-1129.
November 2013
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo, J., Schaarschmidt, H., Liang, L., Cookson, W., Bauerfeind, A., Lee-Kirsch, M.A., Nemat, K., Henderson, J., Paternoster, L., Harper, J.L., Mangold, E., Nothen, M.M., Rüschendorf, F., Kerscher, T., Marenholz, I., Matanovic, A., Lau, S., Keil, T., Bauer, C.P., Kurek, M., Ciechanowicz, A., Macek, M., Franke, A., Kabesch, M., Hubner, N., Abecasis, G., Weidinger, S., Moffatt, M. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 132
(2): 371-377.
August 2013
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud, A., Hermsen, R., Guryev, V., Stridh, P., Graham, D., McBride, M.W., Foroud, T., Calderari, S., Diez, M., Ockinger, J., Beyeen, A.D., Gillett, A., Abdelmagid, N., Guerreiro-Cacais, A.O., Jagodic, M., Tuncel, J., Norin, U., Beattie, E., Huynh, N., Miller, W.H., Koller, D.L., Alam, I., Falak, S., Osborne-Pellegrin, M., Martinez-Membrives, E., Canete, T., Blazquez, G., Vicens-Costa, E., Mont-Cardona, C., Diaz-Moran, S., Tobena, A., Hummel, O., Zelenika, D., Saar, K., Patone, G., Bauerfeind, A., Bihoreau, M.T., Heinig, M., Lee, Y.A., Rintisch, C., Schulz, H., Wheeler, D.A., Worley, K.C., Muzny, D.M., Gibbs, R.A., Lathrop, M., Lansu, N., Toonen, P., Ruzius, F.P., de Bruijn, E., Hauser, H., Adams, D.J., Keane, T., Atanur, S.S., Aitman, T.J., Flicek, P., Malinauskas, T., Jones, E.Y., Ekman, D., Lopez-Aumatell, R., Dominiczak, A.F., Johannesson, M., Holmdahl, R., Olsson, T., Gauguier, D., Hubner, N., Fernandez-Teruel, A., Cuppen, E., Mott, R. and Flint, J.
Nature Genetics 45
(7): 767-775.
July 2013
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M., Takahashi, A., Nakamura, Y., Tsoi, L.C., Stuart, P., Elder, J.T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M.M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B.O., Duerr, R.H., Büning, C., Brandt, S., Glas, J., McAleer, M.A., Fahy, C.M., Kabesch, M., Brown, S., McLean, W.H.I., Irvine, A.D., Schreiber, S., Lee, Y.A., Franke, A. and Weidinger, S.
Nature Genetics 45
(7): 808-812.
July 2013
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.
Dizier, M.H., Margaritte-Jeannin, P., Madore, A.M., Esparza-Gordillo, J., Moffatt, M.F., Corda, E., Monier, F., Guilloud-Bataille, M., Franke, A., Weidinger, S., Annesi-Maesano, I., Just, J., Pin, I., Kauffmann, F., Cookson, W., Lee, Y.A., Laprise, C., Lathrop, M., Bouzigon, E. and Demenais, F.
Journal of Allergy and Clinical Immunology 129
(6): 1547-1553.
June 2012
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S.R., Bauerfeind, A., Hummel, O., Lee, Y.A., Paskas, S., Rintisch, C., Saar, K., Cooper, J., Buchan, R., Gray, E.E., Cyster, J.G., Braund, P., Gracey, J., Krishnan, U., Moore, J.S., Nelson, C.P., Pollard, H., Attwood, T., Crisp-Hihn, A., Foad, N., Jolley, J., Lloyd-Jones, H., Muir, D., Murray, E., O'Leary, K., Rankin, A., Sambrook, J., Godfroy, T., Brocheton, J., Proust, C., Schmitz, G., Heimerl, S., Lugauer, I., Belz, S., Gulde, S., Linsel-Nitschke, P., Sager, H., Schroeder, L., Lundmark, P., Syvannen, A.C., Neudert, J., Scholz, M., Deloukas, P., Gray, E., Gwilliams, R., Niblett, D., Erdmann, J., Hengstenberg, C., Maouche, S., Ouwehand, W.H., Rice, C.M., Samani, N.J., Schunkert, H., Goodall, A.H., Schulz, H., Roider, H.G., Vingron, M., Blankenberg, S., Muenzel, T., Zeller, T., Szymczak, S., Ziegler, A., Tiret, L., Smyth, D.J., Pravenec, M., Aitman, T.J., Cambien, F., Clayton, D., Todd, J.A., Huebner, N. and Cook, S.A.
Nature 467
(7314): 460-464.
23 September 2010
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo, J., Weidinger, S., Foelster-Holst, R., Bauerfeind, A., Rueschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., Huebner, N., Wahn, U., Schreiber, S., Franke, A., Vogler, R., Heath, S., Baurecht, H., Novak, N., Rodriguez, E., Illig, T., Lee-Kirsch, M.A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M., Lee, Y.A. and Ruether, A.
Nature Genetics 41
(5): 596-601.
May 2009
SNP and haplotype mapping for genetic analysis in the rat.
Saar, K., Beck, A., Bihoreau, M.T., Birney, E., Brocklebank, D., Chen, Y., Cuppen, E., Demonchy, S., Dopazo, J., Flicek, P., Foglio, M., Fujiyama, A., Gut, I.G., Gauguier, D., Guigo, R., Guryev, V., Heinig, M., Hummel, O., Jahn, N., Klages, S., Kren, V., Kube, M., Kuhl, H., Kuramoto, T., Kuroki, Y., Lechner, D., Lee, Y.A., Lopez-Bigas, N., Lathrop, G.M., Mashimo, T., Medina, I., Mott, R., Patone, G., Perrier-Cornet, J.A., Platzer, M., Pravenec, M., Reinhardt, R., Sakaki, Y., Schilhabel, M., Schulz, H., Serikawa, T., Shikhagaie, M., Tatsumoto, S., Taudien, S., Toyoda, A., Voigt, B., Zelenika, D., Zimdahl, H. and Huebner, N.
Nature Genetics 40
(5): 560-566.
May 2008
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Pasternack, S.M., von Kuegelgen, I., Aboud, K.A., Lee, Y.A., Rueschendorf, F., Voss, K., Hillmer, A.M., Molderings, G.J., Franz, T., Ramirez, A., Nuernberg, P., Noethen, M.M. and Betz, R.C.
Nature Genetics 40
(3): 329-334.
March 2008
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch, M.A., Gong, M., Chowdhury, D., Senenko, L., Engel, K., Lee, Y.A., de Silva, U., Bailey, S.L., Witte, T., Vyse, T.J., Kere, J., Pfeiffer, C., Harvey, S., Wong, A., Koskenmies, S., Hummel, O., Rohde, K., Schmidt, R.E., Dominiczak, A.F., Gahr, M., Hollis, T., Perrino, F.W., Lieberman, J. and Huebner, N.
Nature Genetics 39
(9): 1065-1067.
September 2007
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C., Marenholz, I., Kerscher, T., Rueschendorf, F., Esparza-Gordillo, J., Worm, M., Gruber, C., Mayr, G., Albrecht, M., Rohde, K., Schulz, H., Wahn, U., Huebner, N. and Lee, Y.A.
PLoS Biology 5
(9): e242.
September 2007
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
Schumacher, J., Kaneva, R., Jamra, R.A., Diaz, G.O., Ohlraun, S., Milanova, V., Lee, Y.A., Rivas, F., Mayoral, F., Fuerst, R., Flaquer, A., Windemuth, C., Gay, E., Sanz, S., Gonzalez, M.J., Gil, S., Cabaleiro, F., del Rio, F., Perez, F., Haro, J., Kostov, C., Chorbov, V., Nikolova-Hill, A., Stoyanova, V., Onchev, G., Kremensky, I., Strauch, K., Schulze, T.G., Nuernberg, P., Gaebel, W., Klimke, A., Auburger, G., Wienker, T.F., Kalaydjieva, L., Propping, P., Cichon, S., Jablensky, A., Rietschel, M. and Noethen, M.M.
American Journal of Human Genetics 77
(6): 1102-1111.
1 December 2005
A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H., Nyakatura, G., Brandt, P., Schulz, H., Hummel, O., Fartmann, B., Brett, D., Droege, M., Monti, J., Lee, Y.A., Sun, Y.Y., Zhao, S.Y., Winter, E.E., Ponting, C.P., Chen, Y., Kasprzyk, A., Birney, E., Ganten, D. and Hubner, N.
Science 303
(5659): 807-807.
1 January 2004
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C., Schoser, B.G.H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.A., Nothen, M.M., Wienker, T.F., Malin, J.P., Propping, P., Reis, A., Mortier, W., Jentsch, T.J., Vorgerd, M. and Kubisch, C.
Nature Genetics 28
(3): 218-219.
July 2001
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee, Y.A., Wahn, U., Kehrt, R., Tarani, L., Businco, L., Gustafsson, D., Andersson, F., Oranje, A.P., Wolkertstorfer, A., von Berg, A., Hoffmann, U., Kuester, W., Wienker, T.F., Rueschendorf, F. and Reis, A.
Nature Genetics 26
: 470-473.
1 December 2000
Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Lee, Y.A., Rueschendorf, F., Windemuth, C., Schmitt-Egenolf, M., Stadelmann, A., Nuernberg, G., Staender, M., Wienker, T.F., Reis, A. and Traupe, H.
American Journal of Human Genetics 67
(4): 1020-1024.
1 October 2000
Localization of a gene for syndactyly type 1 to chromosome 2q34-q36.
Bosse, K., Betz, R.C., Lee, Y.A., Wienker, T.F., Reis, A., Kleen, H., Propping, P., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 67
: 492-497.
1 August 2000
A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
Betz, R.C., Lee, Y.A., Bygum, A., Brandrup, F., Bernal, A.I., Toribio, J., Alvarez, J.I., Kukuk, G.M., Ibsen, H.H.W., Rasmussen, H.B., Wienker, T.F., Reis, A., Propping, P., Kruse, R., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 66
: 1979-1983.
1 June 2000
A gene for an autosomal dominant scleroatrophic syndrome predisposing to skin cancer (Huriez Syndrome) maps to chromosome 4q23.
Lee, Y.A., Stevens, H.P., Delaporte, E., Wahn, U. and Reis, A.
American Journal of Human Genetics 66
: 326-330.
1 January 2000
Leonhardt, Heinrich
Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L., Carlton, P.M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B., Cardoso, M.C., Agard, D.A., Gustafsson, M.G., Leonhardt, H. and Sedat, J.W.
Science 320
(5881): 1332-1336.
6 June 2008
Leutz, Achim
Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M., Chao, C.C., Wang, Y.C., Kenison, J.E., Li, Z., Rone, J.M., Rejano-Gordillo, C.M., Polonio, C.M., Gutierrez-Vazquez, C., Piester, G., Plasencia, A., Li, L., Giovannoni, F., Lee, H.G., Faust Akl, C., Wheeler, M.A., Mascanfroni, I., Jaronen, M., Alsuwailm, M., Hewson, P., Yeste, A., Andersen, B.M., Franks, D.G., Huang, C.J., Ekwudo, M., Tjon, E.C., Rothhammer, V., Takenaka, M., de Lima, K.A., Linnerbauer, M., Guo, L., Covacu, R., Queva, H., Fonseca-Castro, P.H., Bladi, M.A., Cox, L.M., Hodgetts, K.J., Hahn, M.E., Mildner, A., Korzenik, J., Hauser, R., Snapper, S.B. and Quintana, F.J.
Nature 611
(7937): 801-809.
24 November 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A., Sonnemann, J., Amann, K., Mildner, A., Lodka, D., Kling, L., Bieringer, M., Schneider, U., Leutz, A., Enghard, P., Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81
(8): 1162-1172.
August 2022
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A., Wagner, L.K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., Leutz, A., Amit, I. and Mildner, A.
Nature Immunology 21
(5): 525-534.
May 2020
C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B., Maurizio, J., Kandalla, P.K., Brisou, G., Simonnet, L., Huber, C., Gimenez, G., Matcovitch-Natan, O., Reinhardt, S., David, E., Mildner, A., Leutz, A., Nadel, B., Bordi, C., Amit, I., Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26
(5): 657-674.
May 2020
Mapping the lung.
Mildner, A. and Yona, S.
Science 363
(6432): 1154-1155.
15 March 2019
Good things come in threes.
Yona, S. and Mildner, A.
Science Immunology 3
(30): eaav5545.
7 December 2018
Developmental and functional heterogeneity of monocytes.
Guilliams, M., Mildner, A. and Yona, S.
Immunity 49
(4): 595-613.
16 October 2018
SIRT1 regulates macrophage self-renewal.
Imperatore, F., Maurizio, J., Vargas Aguilar, S., Busch, C.J., Favret, J., Kowenz-Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., Berruyer, C. and Sieweke, M.H.
EMBO Journal 36
(16): 2353-2372.
15 August 2017
Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A., Schönheit, J., Giladi, A., David, E., Lara-Astiaso, D., Lorenzo-Vivas, E., Paul, F., Chappell-Maor, L., Priller, J., Leutz, A., Amit, I. and Jung, S.
Immunity 46
(5): 849-862.
16 May 2017
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E., Iwata, A., Albring, J., Wu, X., Tussiwand, R., Kc, W., Kretzer, N.M., Briseno, C.G., Durai, V., Bagadia, P., Haldar, M., Schoenheit, J., Rosenbauer, F., Murphy, T.L. and Murphy, K.M.
Nature Immunology 16
(7): 708-717.
July 2015
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Scheller, M., Schönheit, J., Zimmermann, K., Leser, U., Rosenbauer, F. and Leutz, A.
Journal of Experimental Medicine 210
(11): 2239-2256.
21 October 2013
A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
Pless, O., Kowenz-Leutz, E., Dittmar, G. and Leutz, A.
Nature Protocols 6
(3): 359-364.
February 2011
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Orinska, Z., Foeger, N., Huber, M., Marschall, J., Mirghomizadeh, F., Du, X., Scheller, M., Rosenstiel, P., Goldmann, T., Bollinger, A., Beutler, B.A. and Bulfone-Paus, S.
Blood 116
(15): 2665-2675.
14 October 2010
Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E., Pless, O., Dittmar, G., Knoblich, M. and Leutz, A.
EMBO Journal 29
(6): 1105-1115.
17 March 2010
C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K., Bégay, V., Smink, J.J., Zaragoza, K., Wiesenthal, V., Doerken, B., Calkhoven, C.F. and Leutz, A.
Genes & Development 24
(1): 15-20.
1 January 2010
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M., Vockentanz, L., Kharazi, S., Huska, M.R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., Nerlov, C., Leutz, A., Andrade-Navarro, M.A., Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41
(11): 1207-1215.
November 2009
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G., Scheller, M., Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W., Leutz, A., Huelsken, J. and Held, W.
Blood 111
(1): 142-149.
1 January 2008
Analysis of translation initiation using a translation control reporter system.
Wiesenthal, V., Leutz, A. and Calkhoven, C.F.
Nature Protocols 1
(3): 1531-1537.
9 November 2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7
(10): 1037-1047.
October 2006
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C. and Tenen, D.G.
Nature Genetics 38
(1): 27-37.
January 2006
Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain.
Mo, X., Kowenz-Leutz, E., Laumonnier, Y., Xu, H. and Leutz, A.
Genes & Development 19
(20): 2447-2457.
29 September 2005
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F., Raetzel, N., Mueller, C., Calkhoven, C.F., Kley, K., Mathas, S., Lietz, A., Leutz, A. and Doerken, B.
Blood 106
: 1801-1807.
1 January 2005
Ras induces mediator complex exchange on C/EBPβ.
Mo, X.M., Kowenz-Leutz, E., Xu, H. and Leutz, A.
Molecular Cell 13
(2): 241-250.
30 January 2004
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Bourbon, H.M., Aguilera, A., Ansari, A.Z., Asturias, F.J., Berk, A.J., Bjorklund, S., Blackwell, T.K., Borggrefe, T., Carey, M., Carlson, M., Conaway, J.W., Conaway, R.C., Emmons, S.W., Fondell, J.D., Freedman, L.P., Fukasawa, T., Gustafsson, C.M., Han, M., He, X., Herman, P.K., Hinnebusch, A.G., Holmberg, S., Holstege, F.C., Jaehning, J.A., Kim, Y.J., Kuras, L., Leutz, A., Lis, J.T., Meisterernest, M., Naar, A.M., Nasmyth, K., Parvin, J.D., Ptashne, M., Reinberg, D., Ronne, H., Sadowski, I., Sakurai, H., Sipiczki, M., Sternberg, P.W., Stillman, D.J., Strich, R., Struhl, K., Svejstrup, J.Q., Tuck, S., Winston, F., Roeder, R.G. and Kornberg, R.D.
Molecular Cell 14
(5): 553-557.
1 January 2004
Translational control of SCL-isoform expression in hematopoietic lineage choice.
Calkhoven, C.F., Mueller, C., Martin, R., Krosl, G., Hoang, T. and Leutz, A.
Genes & Development 17
(8): 959-964.
15 April 2003
Activation of the Notch-regulated transcription factor CBF1/RBP-J kappa through the 13SE1A oncoprotein.
Ansieau, S., Strobl, L.J. and Leutz, A.
Genes & Development 15
(4): 380-385.
1 January 2001
Chromatin remodeling in development and differentiation.
Mueller, C. and Leutz, A.
Current Opinion in Genetics & Development 11
(2): 167-174.
1 January 2001
Cooperation between C/EBP alphaTBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Pedersen, T.A., Kowenz-Leutz, E., Leutz, A. and Nerlov, C.
Genes & Development 15
(21): 3208-3216.
1 January 2001
Translational control of C/EBP alpha and C/EBP beta isoform expression.
Calkhoven, C.F., Mueller, C. and Leutz, A.
Genes & Development 14
(15): 1920-1932.
1 August 2000
A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.
Kowenz-Leutz, E. and Leutz, A.
Molecular Cell 4
(5): 735-743.
November 1999
Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways.
Mueller, C., Alunni-Fabroni, M., Kowenz-Leutz, E., Mo, X.M., Tommasino, M. and Leutz, A.
Proceedings of the National Academy of Sciences of the United States of America 96
: 7276-7281.
22 June 1999
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Nerlov, C., McNagny, K.M., Doederlein, G., Kowenz-Leutz, E. and Graf, T.
Genes & Development 12
(15): 2413-2423.
1 August 1998
The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.
Kowenz-Leutz, E., Herr, P., Niss, K. and Leutz, A.
Cell 91
: 185-195.
1 January 1997
NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.
Mueller, C., Kowenz-Leutz, E., Grieser-Ade, S., Graf, T. and Leutz, A.
EMBO Journal 14
(24): 6127-6135.
1 January 1995
Novel mechanism of C/EBPbeta (NF-M) transcriptional control: activation through derepression.
Kowenz-Leutz, E., Twamley, G., Ansieau, S. and Leutz, A.
Genes & Development 8
(22): 2781-2791.
15 November 1994
Lewin, Gary
Piezo2 voltage-block regulates mechanical pain sensitivity.
Sánchez-Carranza, O., Chakrabarti, S., Kühnemund, J., Schwaller, F., Bégay, V., García-Contreras, J.A., Wang, Lin and Lewin, G.R.
Brain 147
(10): 3487-3500.
October 2024
Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383
(6686): 992-998.
1 March 2024
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15
(1): 898.
6 February 2024
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees, T.A., Wang, N., Adamek, P., Zeitzschel, N., Verkest, C., La Porta, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Begay, V., Lee, Y.J., Tappe-Theodor, A., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
Nature Communications 14
(1): 1899.
5 April 2023
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier, M., Gupta, M., Akgül, S., McDougall, M., Imhof, T., Nikodemus, D., Reuten, R., Moya-Torres, A., To, V., Ferens, F., Heide, F., Padilla-Meier, G.P., Kukura, P., Huang, W., Gerisch, B., Mörgelin, M., Poole, K., Antebi, A., Koch, M. and Stetefeld, J.
Nature Communications 14
(1): 1226.
3 March 2023
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brieño-Enríquez, M.A., Bronner, G.N., Coen, C., Delaney, M.A., Dengler-Crish, C.M., Edrey, Y.H., Faulkes, C.G., Frankel, D., Friedlander, G., Gibney, P.A., Gorbunova, V., Hine, C., Holmes, M.M., Jarvis, J.U.M., Kawamura, Y., Kutsukake, N., Kenyon, C., Khaled, W.T., Kikusui, T., Kissil, J., Lagestee, S., Larson, J., Lauer, A., Lavrenchenko, L.A., Lee, A., Levitt, J.B., Lewin, G.R., Lewis Hardell, K.N., Lin, T.D., Mason, M.J., McCloskey, D., McMahon, M., Miura, K., Mogi, K., Narayan, V., O'Connor, T.P., Okanoya, K., O'Riain, M.J., Park, T.J., Place, N.J., Podshivalova, K., Pamenter, M.E., Pyott, S.J., Reznick, J., Ruby, J.G., Salmon, A.B., Santos-Sacchi, J., Sarko, D.K., Seluanov, A., Shepard, A., Smith, M., Storey, K.B., Tian, X., Vice, E.N., Viltard, M., Watarai, Ak., Wywial, E., Yamakawa, M., Zemlemerova, E.D., Zions, M. and Smith, E.S.J.
Biological Reviews 97
(1): 115-140.
February 2022
SPFH protein cage - one ring to rule them all.
Daumke, O. and Lewin, G.R.
Cell Research 32
(2): 117-118.
February 2022
Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J., Veviurko, G., Bennett, N.C., Hart, D.W., Mograby, L. and Lewin, G.R.
Science 371
(6528): 503-507.
29 January 2021
USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Schwaller, F., Bégay, V., García-García, G., Taberner, F.J., Moshourab, R., McDonald, B., Docter, T., Kühnemund, J., Ojeda-Alonso, J., Paricio-Montesinos, R., Lechner, S.G., Poulet, J.F.A., Millan, J.M. and Lewin, G.R.
Nature Neuroscience 24
(1): 74-81.
January 2021
SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N., Taberner, F.J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K.K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S.G., Nawroth, P.P., Lewin, G.R. and Kuner, R.
Neuron 107
(6): 1141-1159.
23 September 2020
The sensory coding of warm perception.
Paricio-Montesinos, R., Schwaller, F., Udhayachandran, A., Rau, F., Walcher, J., Evangelista, R., Vriens, J., Voets, T., Poulet, J.F.A. and Lewin, G.R.
Neuron 106
(5): 830-841.
3 June 2020
Rapid molecular evolution of pain insensitivity in multiple African rodents.
Eigenbrod, O., Debus, K.Y., Reznick, J., Bennett, N.C., Sánchez-Carranza, O., Omerbašić, D., Hart, D.W., Barker, A.J., Zhong, W., Lutermann, H., Katandukila, J.V., Mgode, G., Park, T.J. and Lewin, G.R.
Science 364
(6443): 852-859.
31 May 2019
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E., Loud, M.C., Daou, I., Marshall, K.L., Schwaller, F., Kühnemund, J., Francisco, A.G., Keenan, W.T., Dubin, A.E., Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10
(462): eaat9897.
10 October 2018
Voltage gating of mechanosensitive PIEZO channels.
Moroni, M., Servin-Vences, M.R., Fleischer, R., Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9
(1): 1096.
15 March 2018
Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability.
Dawes, J.M., Weir, G.A., Middleton, S.J., Patel, R., Chisholm, K.I., Pettingill, P., Peck, L.J., Sheridan, J., Shakir, A., Jacobson, L., Gutierrez-Mecinas, M., Galino, J., Walcher, J., Kühnemund, J., Kuehn, H., Sanna, M.D., Lang, B., Clark, A.J., Themistocleous, A.C., Iwagaki, N., West, S.J., Werynska, K., Carroll, L., Trendafilova, T., Menassa, D.A., Giannoccaro, M.P., Coutinho, E., Cervellini, I., Tewari, D., Buckley, C., Leite, M.I., Wildner, H., Zeilhofer, H.U., Peles, E., Todd, A.J., McMahon, S.B., Dickenson, A.H., Lewin, G.R., Vincent, A. and Bennett, D.L.
Neuron 97
(4): 806-822.
21 February 2018
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356
(6335): 307-311.
21 April 2017
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20
(2): 209-218.
February 2017
Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
Grandin, M., Meier, M., Delcros, J.G., Nikodemus, D., Reuten, R., Patel, T.R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., Abes, R., Dean, Y., Neves, D., Bernet, A., Depil, S., Schneiders, F., Poole, K., Dante, R., Koch, M., Mehlen, P. and Stetefeld, J.
Cancer Cell 29
(2): 173-185.
8 February 2016
Photoswitchable fatty acids enable optical control of TRPV1.
Frank, J.A., Moroni, M., Moshourab, R., Sumser, M., Lewin, G.R. and Trauner, D.
Nature Communications 6
: 7118.
21 May 2015
GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C., Moroni, M., Lima, W.C., Wende, H., Kirchner, M., Adelfinger, L., Schrenk-Siemens, K., Tappe-Theodor, A., Wetzel, C., Kuich, P.H., Gassmann, M., Roggenkamp, D., Bettler, B., Lewin, G.R., Selbach, M. and Siemens, J.
Cell 160
(4): 759-770.
12 February 2015
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K., Wende, H., Prato, V., Song, K., Rostock, C., Loewer, A., Utikal, J., Lewin, G.R., Lechner, S.G. and Siemens, J.
Nature Neuroscience 18
(1): 10-16.
January 2015
Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade, S.S., Woo, S.H., Dubin, A.E., Moshourab, R.A., Wetzel, C., Petrus, M., Mathur, J., Bégay, V., Coste, B., Mainquist, J., Wilson, A.J., Francisco, A.G., Reddy, K., Qiu, Z., Wood, J.N., Lewin, G.R. and Patapoutian, A.
Nature 516
(7529): 121-125.
4 December 2014
A somatosensory circuit for cooling perception in mice.
Milenkovic, N., Zhao, W.J., Walcher, J., Albert, T., Siemens, J., Lewin, G.R. and Poulet, J.F.A.
Nature Neuroscience 17
(11): 1560-1566.
November 2014
Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole, K., Herget, R., Lapatsina, L., Ngo, H.D. and Lewin, G.R.
Nature Communications 5
: 3520.
24 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
Natural selection and pain meet at a sodium channel.
Lewin, G.R.
Science 342
(6157): 428-429.
25 October 2013
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E.S.J., Wend, P., Purfürst, B., Nuber, U.A., Gurok, U., Matyash, V., Waelzlein, J.H., Chirasani, S.R., Dittmar, G., Cravatt, B.F., Momma, S., Lewin, G.R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H. and Glass, R.
Nature Medicine 18
(8): 1232-1238.
August 2012
A genetic basis for mechanosensory traits in humans.
Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G., Schiska, D., Jaijo, T., Rueschendorf, F., Saar, K., Jordan, J., Millan, J.M., Gross, M. and Lewin, G.R.
PLoS Biology 10
(5): e1001318.
1 May 2012
The transcription factor c-Maf controls touch receptor development and function.
Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. and Birchmeier, C.
Science 335
(6074): 1373-1376.
16 March 2012
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo, C., Gangadharan, V., Bali, K.K., Xie, R.G., Agarwal, N., Kurejova, M., Tappe-Theodor, A., Tegeder, I., Feil, S., Lewin, G., Polgar, E., Todd, A.J., Schlossmann, J., Hofmann, F., Liu, D.L., Hu, S.J., Feil, R., Kuner, T. and Kuner, R.
PLoS Biology 10
(3): e1001283.
13 March 2012
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Heidenreich, M., Lechner, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aranguez, G., Moreno-Pelayo, M.A., Jentsch, T.J. and Lewin, G.R.
Nature Neuroscience 15
(1): 138-145.
2012
The molecular basis of acid insensitivity in the African naked mole-rat.
Smith, E.S.J., Omerbasic, D., Lechner, S.G., Anirudhan, G., Lapatsina, L. and Lewin, G.R.
Science 334
(6062): 1557-1560.
16 December 2011
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Chiang, L.Y., Poole, K., Oliveira, B.E., Duarte, N., Bernal Sierra, Y.A., Bruckner-Tuderman, L., Koch, M., Hu, J. and Lewin, G.R.
Nature Neuroscience 14
(8): 993-1000.
3 July 2011
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan, V., Wang, R., Ulzhoefer, B., Luo, C., Bardoni, R., Bali, K.K., Agarwal, N., Tegeder, I., Hildebrandt, U., Nagy, G.G., Todd, A.J., Ghirri, A., Haeussler, A., Sprengel, R., Seeburg, P.H., Macdermott, A.B., Lewin, G.R. and Kuner, R.
Journal of Clinical Investigation 121
(4): 1608-1623.
1 April 2011
The molecular and cellular identity of peripheral osmoreceptors.
Lechner, S.G., Markworth, S., Poole, K., Smith, E.S.J., Lapatsina, L., Frahm, S., May, M., Pischke, S., Suzuki, M., Ibanez-Tallon, I., Luft, F.C., Jordan, J. and Lewin, G.R.
Neuron 69
(2): 332-344.
27 January 2011
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B., Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14
(1): 54-61.
January 2011
Evidence for a protein tether involved in somatic touch.
Hu, J., Chiang, L.Y., Koch, M. and Lewin, G.R.
EMBO Journal 29
(4): 855-867.
17 February 2010
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J., Lu, Y., Jüttner, R., Smith, E.S.J., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. and Lewin, G.R.
PLoS Biology 6
(1): e13.
29 January 2008
Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N., Frahm, C., Gassmann, M., Griffel, C., Erdmann, B., Birchmeier, C., Lewin, G.R. and Garratt, A.N.
Neuron 56
(5): 893-906.
6 December 2007
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10
(11): 1449-1457.
November 2007
A stomatin-domain protein essential for touch sensation in the mouse.
Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Harder, L., Eilers, A., Moshourab, R., Kozlenkov, A., Labuz, D., Caspani, O., Erdmann, B., Machelska, H., Heppenstall, P.A. and Lewin, G.R.
Nature 445
(7124): 206-209.
11 January 2007
The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain.
Hartmann, B., Ahmadi, S., Heppenstall, P.A., Lewin, G.R., Schott, C., Borchardt, T., Seeburg, P.H., Zeilhofer, H.U., Sprengel, R. and Kuner, R.
Neuron 44
(4): 637-650.
18 November 2004
The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function.
Page, A.J., Brierley, S.M., Martin, C.M., Martinez-Salgado, C., Wemmie, J.A., Brennan, T.J., Symonds, E., Omari, T., Lewin, G.R., Welsh, M.J. and Blackshaw, L.A.
Gastroenterology 127
(6): 1739-1747.
1 January 2004
A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Shin, J.B., Martinez-Salgado, C., Heppenstall, P.A. and Lewin, G.R.
Nature Neuroscience 6
(7): 724-730.
July 2003
cGMP-mediated signaling via cGKIαs required for the guidance and connectivity of sensory axons.
Schmidt, H., Werner, M., Heppenstall, P.A., Henning, M., More, M.I., Kuehbandner, S., Lewin, G.R., Hofmann, F., Feil, R. and Rathjen, F.G.
Journal of Cell Biology 159
(3): 489-498.
11 November 2002
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M. and Birchmeier, C.
Neuron 34
(4): 551-562.
16 May 2002
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.
Postigo, A., Calella, A.M., Fritzsch, B., Knipper, M., Katz, D., Eilers, A., Schimmang, T., Lewin, G.R., Klein, R. and Minichiello, L.
Genes & Development 16
(5): 633-645.
1 January 2002
The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice.
Price, M.P., McIlwrath, S.L., Xie, J.H., Cheng, C., Qiao, J., Tarr, D.E., Sluka, K.A., Brennan, T.J., Lewin, G.R. and Welsh, M.J.
Neuron 32
(6): 1071-1083.
20 December 2001
BDNF but not NT-4 is required for normal flexion reflex plasticity and function.
Heppenstall, P.A. and Lewin, G.R.
Proceedings of the National Academy of Sciences of the United States of America 98
(14): 8107-8112.
3 July 2001
The mammalian sodium channel BNC1 is required for normal touch sensation.
Price, M.P., Lewin, G.R., McIlwrath, S.L., Cheng, C., Xie, J.H., Heppenstall, P.A., Stucky, C.L., Mannsfeldt, A.G., Brennan, T.J., Drummond, H.A., Qiao, J., Benson, C.J., Tarr, D.E., Hrstka, R.F., Yang, B.L., Williamson, R.A. and Welsh, M.J.
Nature 407
(6807): 1007-1011.
26 October 2000
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.
Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C.M., Calixto, J.B., Lewin, G.R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 8140-8145.
5 July 2000
A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control.
Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., Bulfone-Paus, S., Hagen, E., Braun, A., Lommatzsch, M., Renz, H. and Paus, R.
FASEB Journal 13
: 395-410.
1 February 1999
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.
Minichiello, L., Casagranda, F., Tatche, R.S., Stucky, C.L., Postigo, A., Lewin, G.R., Davies, A.M. and Klein, R.
Neuron 21
: 335-345.
1 August 1998
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G.R. and Birchmeier, C.
Nature 389
(6652): 725-730.
16 October 1997
Neurotrophins live or let die: Does p75NTR decide.
Carter, B.D. and Lewin, G.R.
Neuron 18
: 187-190.
1 January 1997
Lipp, Martin
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Höpken, U.E.
Blood 124
(19): 2897-2898.
6 November 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
Vaeth, M., Mueller, G., Stauss, D., Dietz, L., Klein-Hessling, S., Serfling, E., Lipp, M., Berberich, I. and Berberich-Siebelt, F.
Journal of Experimental Medicine 211
(3): 545-561.
10 March 2014
A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice.
Baddack, U., Hartmann, S., Bang, H., Grobe, J., Loddenkemper, C., Lipp, M. and Mueller, G.
Nature Communications 4
: 1644.
2013
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37
(5): 854-866.
16 November 2012
CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
Nakamoto, N., Ebinuma, H., Kanai, T., Chu, P.S., Ono, Y., Mikami, Y., Ojiro, K., Lipp, M., Love, P.E., Saito, H. and Hibi, T.
Gastroenterology 142
(2): 366-376.
February 2012
Luminal CD4 + T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
Nemoto, Y., Kanai, T., Shinohara, T., Ito, T., Nakamura, T., Okamoto, R., Tsuchiya, K., Lipp, M., Eishi, Y. and Watanabe, M.
Gastroenterology 141
(6): 2130-2139.e11.
December 2011
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10
(11): 1193-1199.
November 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Buonamici, S., Trimarchi, T., Ruocco, M.G., Reavie, L., Cathelin, S., Mar, B.G., Klinakis, A., Lukyanov, Y., Tseng, J.C., Sen, F., Gehrie, E., Li, M., Newcomb, E., Zavadil, J., Meruelo, D., Lipp, M., Ibrahim, S., Efstratiadis, A., Zagzag, D., Bromberg, J.S., Dustin, M.L. and Aifantis, I.
Nature 459
(7249): 1000-1004.
18 June 2009
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.
Schneider, M.A., Meingassner, J.G., Lipp, M., Moore, H.D. and Rot, A.
Journal of Experimental Medicine 204
(4): 735-745.
16 April 2007
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109
(3): 886-895.
1 February 2007
Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.
Yasuda, T., Kuwabara, T., Nakano, H., Aritomi, K., Onodera, T., Lipp, M., Takahama, Y. and Kakiuchi, T.
Blood 109
(2): 449-456.
15 January 2007
Coordination between CCR7- and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.
Liu, C., Saito, F., Liu, Z., Lei, Y., Uehara, S., Love, P., Lipp, M., Kondo, S., Manley, N. and Takahama, Y.
Blood 108
(8): 2531-2539.
15 October 2006
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., Boyd, R.L. and Takahama, Y.
Immunity 24
(2): 165-177.
February 2006
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Debes, G.F., Arnold, C.N., Young, A.J., Krautwald, S., Lipp, M., Hay, J.B. and Butcher, E.C.
Nature Immunology 6
(9): 889-894.
14 August 2005
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W.
Journal of Experimental Medicine 201
(9): 1447-1457.
2 May 2005
Role of CCL21 in recruitment of T precursor cells to fetal thymus.
Liu, C., Ueno, T., Kuse, S., Saito, F., Nitta, T., Piali, L., Nakano, H., Kakiuchi, T., Lipp, M., Hollander, G.A. and Takahama, Y.
Blood 105
(1): 31-39.
1 January 2005
CCR7 signals are essential for cortex-medulla migration of developing thymocytes.
Ueno, T., Saito, F., Gray, D.H.D., Kuse, S., Hieshima, K., Nakano, H., Kakiuchi, T., Lipp, M., Boyd, R.L. and Takahama, Y.
Journal of Experimental Medicine 200
(4): 493-505.
16 August 2004
All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E. and Lipp, M.
Immunity 20
(3): 244-246.
March 2004
Lymphoid organogenesis: getting the green light from RORgammat.
Lipp, M. and Mueller, G.
Nature Immunology 5
(1): 12-14.
1 January 2004
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for TH1 priming.
Martin-Fontecha, A., Thomsen, L.L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A. and Sallusto, F.
Nature Immunology 5
(12): 1260-1265.
1 January 2004
Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Prinz, M., Heikenwalder, M., Junt, T., Schwarz, P., Glatzel, M., Heppner, F.L., Fu, Y.X., Lipp, M. and Aguzzi, A.
Nature 425
(6961): 957-962.
30 October 2003
Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A., Sebastiani, S., Höpken, U.E., Uguccioni, M., Lipp, M., Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198
(4): 615-621.
18 August 2003
Differentiation of effector/memory V ae 2 T cells and migratory routes in lymph nodes or inflammatory sites.
Dieli, F., Poccia, F., Lipp, M., Sireci, G., Caccamo, N., Di Sano, C. and Salerno, A.
Journal of Experimental Medicine 198
(3): 391-397.
4 August 2003
Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs.
Ohl, L., Henning, G., Krautwald, S., Lipp, M., Hardtke, S., Bernhardt, G., Pabst, O. and Foerster, R.
Journal of Experimental Medicine 197
(9): 1199-1204.
5 May 2003
Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development.
Mueller, G. and Lipp, M.
Current Opinion in Immunology 15
(2): 217-224.
April 2003
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma.
Smith, J.R., Braziel, R.M., Paoletti, S., Lipp, M., Uguccioni, M. and Rosenbaum, J.T.
Blood 101
(3): 815-821.
1 February 2003
CD4+CD3- cells induce Peyer's patch development: role of α4 β1 integrin activation by CXCR5.
Finke, D., Acha-Orbea, H., Mattis, A., Lipp, M. and Kraehenbuhl, J.P.
Immunity 17
(3): 363-373.
September 2002
Chemokine requirements for B cell entry to lymph nodes and Peyers patches.
Okada, T., Ngo, V.N., Ekland, E.H., Foerster, R., Lipp, M., Littman, D.R. and Cyster, J.G.
Journal of Experimental Medicine 196
(1): 65-75.
1 July 2002
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Reif, K., Ekland, E.H., Ohl, L., Nakano, H., Lipp, M., Foerster, R. and Cyster, J.G.
Nature 416
: 94-99.
1 January 2002
Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E., Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Immunity 16
(2): 205-218.
1 January 2002
CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: Modulation by FTY720.
Henning, G., Ohl, H., Junt, T., Reiterer, P., Brinkmann, V., Nakano, H., Hohenberger, W., Lipp, M. and Foerster, R.
Journal of Experimental Medicine 194
(12): 1875-1881.
17 December 2001
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
Holst, P.J., Rosenkilde, M.M., Manfra, D., Chen, S.C., Wiekowski, M.T., Holst, B., Cifire, F., Lipp, M., Schwartz, T.W. and Lira, S.A.
Journal of Clinical Investigation 108
(12): 1789-1796.
December 2001
Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC.
Ishikawa, S., Sato, T., Abe, M., Nagai, S., Onai, N., Yoneyama, H., Zhang, Y.Y., Suzuki, T., Hashimoto, S., Shirai, T., Lipp, M. and Matsushima, K.
Journal of Experimental Medicine 193
(12): 1393-1402.
18 June 2001
Skewed maturation of memory HIV-specific CD8 T lymphocytes.
Champagne, P., Ogg, G.S., King, A.S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G.P., Fleury, S., Lipp, M., Foerster, R., Rowland-Jones, S., Sekaly, R.P., McMichael, A.J. and Pantaleo, G.
Nature 410
(6824): 106-111.
1 March 2001
Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.
Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Foerster, R., Lipp, M., Toes, R.E.M., Melief, C.J., Marvel, J. and Vivier, E.
Nature Immunology 2
(5): 430-435.
1 January 2001
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production.
Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M. and Foerster, R.
Journal of Experimental Medicine 192
(11): 1545-1551.
4 December 2000
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.
Schaerli, P., Willimann, K., Lang, A.B., Lipp, M., Loetscher, P. and Moser, B.
Journal of Experimental Medicine 192
(11): 1553-1562.
4 December 2000
A chemokine-driven positive feedback loop organizes lymphoid follicles.
Ansel, K.M., Ngo, V.N., Hyman, P.L., Luther, S.A., Foerster, R., Sedgwick, J.D., Browning, J.L., Lipp, M. and Cyster, J.G.
Nature 406
(6793): 309-314.
20 July 2000
CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.
Cook, D.N., Prosser, D.M., Forster, R., Zhang, J., Kuklin, N.A., Abbondanzo, S.J., Niu, X.D., Chen, S.C., Manfra, D.J., Wiekowski, M.T., Sullivan, L.M., Smith, S.R., Greenberg, H.B., Narula, S.K., Lipp, M. and Lira, S.A.
Immunity 12
(5): 495-503.
1 May 2000
NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue.
Pabst, O., Foerster, R., Lipp, M., Engel, H. and Arnold, H.H.
EMBO Journal 19
(9): 2015-2023.
1 January 2000
Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.
Walker, L.S.K., Gulbranson-Judge, A., Flynn, S., Brocker, T., Raykundalia, C., Goodall, M., Foerster, R., Lipp, M. and Lane, P.
Journal of Experimental Medicine 190
(8): 1115-1122.
18 October 1999
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
Sallusto, F., Lenig, D., Foerster, R., Lipp, M. and Lanzavecchia, A.
Nature 401
(6754): 708-712.
14 October 1999
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Foerster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Mueller, I., Wolf, E. and Lipp, M.
Cell 99
(1): 23-33.
1 October 1999
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen.
Foerster, R., Mattis, A., Kremmer, E., Wolf, E., Brem, G. and Lipp, M.
Cell 87
(6): 1037-1047.
13 December 1996
The E2F transcription factor activates a replication-dependet human H2A gene in early S phase of the cell cycle.
Oswald, F., Dobner, T. and Lipp, M.
Molecular and Cellular Biology 16
(5): 1889-1895.
1 January 1996
Loewer, Alexander (BIMSB)
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K., Wende, H., Prato, V., Song, K., Rostock, C., Loewer, A., Utikal, J., Lewin, G.R., Lechner, S.G. and Siemens, J.
Nature Neuroscience 18
(1): 10-16.
January 2015
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W., Theillet, F.X., Katzer, A., Finzel, A., Mishall, K.M., Powell, A.T., Wu, H., Manieri, W., Dieterich, C., Selenko, P., Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10
(12): 1000-1002.
December 2014
Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E., Rother, M., Kerr, M.C., Al-Zeer, M.A., Abu-Lubad, M., Kessler, M., Brinkmann, V., Loewer, A. and Meyer, T.F.
Nature Communications 5
: 5201.
13 November 2014
Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M., Munschauer, M., Gregersen, L.H., Finzel, A., Loewer, A., Chen, W., Landthaler, M. and Dieterich, C.
Genome Biology 15
(1): R15.
13 January 2014
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495
(7441): 333-338.
21 March 2013
Lohse, Martin
Cell swelling enhances ligand-driven β-adrenergic signaling.
Sirbu, A., Bathe-Peters, M., Kumar, J.L.M, Inoue, A., Lohse, M.J. and Annibale, P.
Nature Communications 15
(1): 7822.
7 September 2024
Functional modulation of PTH1R activation and signaling by RAMP2.
Nemec, K., Schihada, H., Kleinau, G., Zabel, U., Grushevsky, E.O., Scheerer, P., Lohse, M.J. and Maiellaro, I.
Proceedings of the National Academy of Sciences of the United States of America 119
(32): e2122037119.
9 August 2022
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M.J. and Bock, A.
Cell 185
(7): 1130-1142.e11.
31 March 2022
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118
(23): e2101119118.
8 June 2021
Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A., Serfling, R., Möller, J., Thomas, R., De Faveri, C., Zabel, U., Scarselli, M., Beck-Sickinger, A.G., Bock, A., Coin, I., Lohse, M.J. and Annibale, P.
Nature Protocols 16
(3): 1419-1451.
March 2021
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir, A., Möller, J., Arimont, M., Bobkov, V., Perpiñá-Viciano, C., Hoffmann, C., Inoue, A., Heukers, R., de Graaf, C., Smit, M.J., Annibale, P. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 117
(46): 29144-29154.
17 November 2020
Optical mapping of cAMP signaling at the nanometer scale.
Bock, A., Annibale, P., Konrad, C., Hannawacker, A., Anton, S.E., Maiellaro, I., Zabel, U., Sivaramakrishnan, S., Falcke, M. and Lohse, M.J.
Cell 182
(6): 1519-1530.
17 September 2020
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J., Isbilir, A., Sungkaworn, T., Osberg, B., Karathanasis, C., Sunkara, V., Grushevskyi, E.O., Bock, A., Annibale, P., Heilemann, M., Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16
(9): 946-954.
September 2020
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Uroda, T., Chillón, I., Annibale, P., Teulon, J.M., Pessey, O., Karuppasamy, M., Pellequer, J.L. and Marcia, M.
Nature Protocols 15
(6): 2107-2139.
June 2020
Spatial heterogeneity in molecular brightness.
Annibale, P. and Lohse, M.J.
Nature Methods 17
(3): 273-275.
March 2020
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
Uroda, T., Anastasakou, E., Rossi, A., Teulon, J.M., Pellequer, J.L., Annibale, P., Pessey, O., Inga, A., Chillón, I. and Marcia, M.
Molecular Cell 75
(5): 982-995.
5 September 2019
Does divergent binding pocket closure drive ligand bias for class A GPCRs?
Bermudez, M. and Bock, A.
Trends in Pharmacological Sciences 40
(4): 236-239.
April 2019
Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M., Gallion, J., Picard, L.P., Wilkins, A.D., Le Gouill, C., Audet, M., Stallaert, W., Lohse, M.J., Kimmel, M., Lichtarge, O. and Bouvier, M.
Nature Communications 8
(1): 2169.
18 December 2017
Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T., Jobin, M.L., Burnecki, K., Weron, A., Lohse, M.J. and Calebiro, D.
Nature 550
(7677): 543-547.
26 October 2017
Ludwig, Leif (MDC/BIMSB/BIH)
Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations.
Penter, L., Cieri, N., Maurer, K., Kwok, M., Lyu, H., Lu, W.S., Oliveira, G., Gohil, S.H., Leshchiner, I., Lareau, C.A., Ludwig, L.S., Neuberg, D.S., Kim, H.T., Li, S., Bullinger, L., Ritz, J., Getz, G., Garcia, J.S., Soiffer, R.J., Livak, K.J. and Wu, C.J.
Blood Cancer Discovery 5
(6): 442-459.
1 November 2024
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B., Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T., Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D., Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology
28 September 2024
(In Press)
Mitochondrial genetics through the lens of single-cell multi-omics.
Nitsch, L., Lareau, C.A. and Ludwig, L.S.
Nature Genetics 56
(7): 1355-1365.
July 2024
Systematic benchmarking of single-cell ATAC-sequencing protocols.
De Rop, F.V., Hulselmans, G., Flerin, C., Soler-Vila, P., Rafels, A., Christiaens, V., González-Blas, C.B., Marchese, D., Caratù, G., Poovathingal, S., Rozenblatt-Rosen, O., Slyper, M., Luo, W., Muus, C., Duarte, F., Shrestha, R., Bagdatli, S.T., Corces, M.R., Mamanova, L., Knights, A., Meyer, K.B., Mulqueen, R., Taherinasab, A., Maschmeyer, P., Pezoldt, J., Lambert, C.L.G., Iglesias, M., Najle, S.R., Dossani, Z.Y., Martelotto, L.G., Burkett, Z., Lebofsky, R., Martin-Subero, J.I., Pillai, S., Sebé-Pedrós, A., Deplancke, B., Teichmann, S.A., Ludwig, L.S., Braun, T.P., Adey, A.C., Greenleaf, W.J., Buenrostro, J.D., Regev, A., Aerts, S. and Heyn, H.
Nature Biotechnology 42
(6): 916-926.
June 2024
Latent human herpesvirus 6 is reactivated in CAR T cells.
Lareau, C.A., Yin, Y., Maurer, K., Sandor, K.D., Daniel, B., Yagnik, G., Peña, J., Crawford, J.C., Spanjaart, A.M., Gutierrez, J.C., Haradhvala, N.J., Riberdy, J.M., Abay, T., Stickels, R.R., Verboon, J.M., Liu, V., Buquicchio, F.A., Wang, F., Southard, J., Song, R., Li, W., Shrestha, A., Parida, L., Getz, G., Maus, M.V., Li, S., Moore, A., Roberts, Z.J., Ludwig, L.S., Talleur, A.C., Thomas, P.G., Dehghani, H., Pertel, T., Kundaje, A., Gottschalk, S., Roth, T.L., Kersten, M.J., Wu, C.J., Majzner, R.G. and Satpathy, A.T.
Nature 623
: 608-615.
16 November 2023
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.
Lareau, C.A., Dubois, S.M., Buquicchio, F.A., Hsieh, Y.H., Garg, K., Kautz, P., Nitsch, L., Praktiknjo, S.D., Maschmeyer, P., Verboon, J.M., Gutierrez, J.C., Yin, Y., Fiskin, E., Luo, W., Mimitou, E.P., Muus, C., Malhotra, R., Parikh, S., Fleming, M.D., Oevermann, L., Schulte, J., Eckert, C., Kundaje, A., Smibert, P., Vardhana, S.A., Satpathy, A.T., Regev, A., Sankaran, V.G., Agarwal, S. and Ludwig, L.S.
Nature Genetics 55
(7): 1198-1209.
July 2023
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.
Lareau, C.A., Liu, V., Muus, C., Praktiknjo, S.D., Nitsch, L., Kautz, P., Sandor, K., Yin, Y., Gutierrez, J.C., Pelka, K., Satpathy, A.T., Regev, A., Sankaran, V.G. and Ludwig, L.S.
Nature Protocols 18
(5): 1416-1440.
May 2023
Mitochondrial DNA mutations as natural barcodes for lineage tracing of murine tumor models.
Penter, L., Ten Hacken, E., Southard, J., Lareau, C., Ludwig, L.S., Li, S., Neuberg, D.S., Livak, K.J. and Wu, C.J.
Cancer Research 83
(5): 667-672.
1 March 2023
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
Rückert, T., Lareau, C.A., Mashreghi, M.F., Ludwig, L.S. and Romagnani, C.
Nature Immunology 23
(11): 1551-1563.
November 2022
Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1.
Ludwig, L.S., Lareau, C.A., Bao, E.L., Liu, N., Utsugisawa, T., Tseng, A.M., Myers, S.A., Verboon, J.M., Ulirsch, J.C., Luo, W., Muus, C., Fiorini, C., Olive, M.E., Vockley, C.M., Munschauer, M., Hunter, A., Ogura, H., Yamamoto, T., Inada, H., Nakagawa, S., Ozono, S., Subramanian, V., Chiarle, R., Glader, B., Carr, S.A., Aryee, M.J., Kundaje, A., Orkin, S., Regev, A., McCavit, T., Kanno, H. and Sankaran, V.G.
Blood 139
(16): 2534-2546.
21 April 2022
Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Fiskin, E., Lareau, C.A., Ludwig, L.S., Eraslan, G., Liu, F., Ring, A.M., Xavier, R.J. and Regev, A.
Nature Biotechnology 40
(3): 374-381.
March 2022
Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.
Miller, T.E., Lareau, C.A., Verga, J.A., DePasquale, E.A.K., Liu, V., Ssozi, D., Sandor, K., Yin, Y., Ludwig, L.S., El Farran, C.A., Morgan, D.M., Satpathy, A.T., Griffin, G.K., Lane, A.A., Love, J.C., Bernstein, B.E., Sankaran, V.G. and van Galen, P.
Nature Biotechnology 40
(7): 1030-1034.
24 February 2022
Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L., Gohil, S.H., Lareau, C., Ludwig, L.S., Parry, E.M., Huang, T., Li, S., Zhang, W., Livitz, D., Leshchiner, I., Parida, L., Getz, G., Rassenti, L.Z., Kipps, T.J., Brown, J.R., Davids, M.S., Neuberg, D.S., Livak, K.J., Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11
(12): 3048-3063.
December 2021
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
Mimitou, E.P., Lareau, C.A., Chen, K.Y., Zorzetto-Fernandes, A.L., Hao, Y., Takeshima, Y., Luo, W., Huang, T.S., Yeung, B.Z., Papalexi, E., Thakore, P.I., Kibayashi, T., Wing, J.B., Hata, M., Satija, R., Nazor, K.L., Sakaguchi, S., Ludwig, L.S., Sankaran, V.G., Regev, A. and Smibert, P.
Nature Biotechnology 39
(10): 1246-1258.
October 2021
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C., Luecken, M.D., Eraslan, G., Sikkema, L., Waghray, A., Heimberg, G., Kobayashi, Y., Vaishnav, E.D., Subramanian, A., Smillie, C., Jagadeesh, K.A., Duong, E.T., Fiskin, E., Triglia, E.T., Ansari, M., Cai, P., Lin, B., Buchanan, J., Chen, S., Shu, J., Haber, A.L., Chung, H., Montoro, D.T., Adams, T., Aliee, H., Allon, S.J., Andrusivova, Z., Angelidis, I., Ashenberg, O., Bassler, K., Bécavin, C., Benhar, I., Bergenstråhle, J., Bergenstråhle, L., Bolt, L., Braun, E., Bui, L.T., Callori, S., Chaffin, M., Chichelnitskiy, E., Chiou, J., Conlon, T.M., Cuoco, M.S., Cuomo, A.S.E., Deprez, M., Duclos, G., Fine, D., Fischer, D.S., Ghazanfar, S., Gillich, A., Giotti, B., Gould, J., Guo, M., Gutierrez, A.J., Habermann, A.C., Harvey, T., He, P., Hou, X., Hu, L., Hu, Y., Jaiswal, A., Ji, L., Jiang, P., Kapellos, T.S., Kuo, C.S., Larsson, L., Leney-Greene, M.A., Lim, K., Litviňuková, M., Ludwig, L.S., Lukassen, S., Luo, W., Maatz, H., Madissoon, E., Mamanova, L., Manakongtreecheep, K., Leroy, S., Mayr, C.H., Mbano, I.M., McAdams, A.M., Nabhan, A.N., Nyquist, S.K., Penland, L., Poirion, O.B., Poli, S., Qi, C.C., Queen, R., Reichart, D., Rosas, I., Schupp, J.C., Shea, C.V., Shi, X., Sinha, R., Sit, R.V., Slowikowski, K., Slyper, M., Smith, N.P., Sountoulidis, A., Strunz, M., Sullivan, T.B., Sun, D., Talavera-López, C., Tan, P., Tantivit, J., Travaglini, K.J., Tucker, N.R., Vernon, K.A., Wadsworth, M.H., Waldman, J., Wang, X., Xu, K., Yan, W., Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27
(3): 546-559.
2 March 2021
Luft, Friedrich C. (MDC/ECRC)
Water conservation overrides osmotic diuresis during SGLT2 inhibition in patients with heart failure.
Marton, A., Saffari, S.E., Rauh, M., Sun, R.N., Nagel, A.M., Linz, P., Lim, T.T., Takase-Minegishi, K., Pajarillaga, A., Saw, S., Morisawa, N., Yam, W.K., Minegishi, S., Totman, J.J., Teo, S., Teo, L.L.Y., Ng, C.T., Kitada, K., Wild, J., Kovalik, J.P., Luft, F.C., Greasley, P.J., Chin, C.W.L., Sim, D.K.L. and Titze, J.
Journal of the American College of Cardiology 83
(15): 1386-1398.
16 April 2024
SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A., López-Cayuqueo, K.I., Scherer, N., Wuttke, M., Wernstedt, A., González Fassrainer, D., Smith, D.E., van de Kamp, J.M., Ziegeler, K., Eckardt, K.U., Luft, F.C., Aronson, P.S., Köttgen, A., Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133
(3): e161849.
1 February 2023
The Case: Is this hemolytic uremic syndrome?
Kettritz, R., Düttmann, W., Brand, A. and Luft, F.C.
Kidney International 102
(5): 1195-1196.
November 2022
Epigenetic "transgenerational" inheritance.
Luft, F.C.
Circulation 146
(14): 1096-1098.
4 October 2022
Translating plasma sodium, stores, and hydration state from mouse to man.
Luft, F.C.
European Heart Journal 43
(35): 3349-3351.
14 September 2022
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
(6): 1653-1668.
December 2021
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13
(1): 713-727.
February 2021
I'm pickin' up good dilations.
Luft, F.C.
Cardiovascular Research 117
(1): 27-28.
1 January 2021
Salt and cardiovascular disease: insufficient evidence to recommend low sodium intake.
O'Donnell, M., Mente, A., Alderman, M.H., Brady, A.J.B., Diaz, R., Gupta, R., López-Jaramillo, P., Luft, F.C., Lüscher, T.F., Mancia, G., Mann, J.F.E., McCarron, D., McKee, M., Messerli, F.H., Moore, L.L., Narula, J., Oparil, S., Packer, M., Prabhakaran, D., Schutte, A., Sliwa, K., Staessen, J.A., Yancy, C. and Yusuf, S.
European Heart Journal 41
(35): 3363-3373.
14 September 2020
Norman M. Kaplan: January 2, 1931-April 5, 2020.
Townsend, R.R., DiPette, D.J., Luft, F.C., Weinberger, M.H. and Ram, V.
Hypertension 76
(2): 291-293.
August 2020
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N., Foster, D.J., Cunningham, M.W., Bercher, J., Nguyen, T., Shulga-Morskaya, S., Milstein, S., Shaikh, S., Rollins, J., Golic, M., Herse, F., Kräker, K., Bendix, I., Serdar, M., Napieczynska, H., Heuser, A., Gellhaus, A., Thiele, K., Wallukat, G., Müller, D.N., LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130
(6): 2928-2942.
1 June 2020
B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116
(5): 1059-1070.
1 April 2020
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11
(1): 103-119.
February 2020
Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome.
Maass, P.G., Weise, A., Rittscher, K., Lichtenwald, J., Barutcu, A.R., Liehr, T., Aydin, A., Wefeld-Neuenfeld, Y., Pölsler, L., Tinschert, S., Rinn, J.L., Luft, F.C. and Bähring, S.
EMBO Journal 37
(15): e96257.
1 August 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J., Singh, M., Herse, F., Przybyl, L., Haase, N., Golic, M., Yung, H.W., Huppertz, B., Cartwright, J.E., Whitley, G.S., Johnsen, G.M., Levi, G., Isbruch, A., Schulz, H., Luft, F.C., Müller, D.N., Staff, A.C., Hurst, L.D., Dechend, R. and Izsvák, Z.
Circulation 136
(19): 1824-1839.
7 November 2017
Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
Eulenberg-Gustavus, C., Bähring, S., Maass, P., Luft, F.C. and Kettritz, R.
Journal of Experimental Medicine 214
(7): 2089-2101.
3 July 2017
High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K., Daub, S., Zhang, Y., Klein, J. D., Nakano, D., Pedchenko, T., Lantier, L., LaRocque, L.M., Marton, A., Neubert, P., Schröder, A., Rakova, N., Jantsch, J., Dikalova, A.E., Dikalov, S.I., Harrison, D.G., Müller, D.N., Nishiyama, A., Rauh, M., Harris, R. C., Luft, F.C., Wassermann, D.H., Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127
(5): 1944-1959.
1 May 2017
Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N., Kitada, K., Lerchl, K., Dahlmann, A., Birukov, A., Daub, S., Kopp, C., Pedchenko, T., Zhang, Y., Beck, L., Johannes, B., Marton, A., Müller, D.N., Rauh, M., Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127
(5): 1932-1943.
1 May 2017
The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association.
Mancia, G., Oparil, S., Whelton, P.K., McKee, M., Dominiczak, A., Luft, F.C., AlHabib, K., Lanas, F., Damasceno, A., Prabhakaran, D., La Torre, G., Weber, M., O'Donnell, M., Smith, S.C. and Narula, J.
European Heart Journal 38
(10): 712-719.
7 March 2017
Risk factors: evolving epidemiology of sodium intake and CVD.
Luft, F.C.
Nature Reviews Cardiology 13
(8): 445-446.
August 2016
CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L., Haase, N., Golic, M., Rugor, J., Solano, M.E., Arck, P.C., Gauster, M., Huppertz, B., Emontzpohl, C., Stoppe, C., Bernhagen, J., Leng, L., Bucala, R., Schulz, H., Heuser, A., Weedon-Fekjær, S., Johnsen, G.M., Peetz, D., Luft, F.C., Staff, A.C., Müller, D.N., Dechend, R. and Herse, F.
Circulation Research 119
(1): 55-68.
24 June 2016
11-β hydroxysteroid dehydrogenase-2 and salt-sensitive hypertension.
Luft, F.C.
Circulation 133
(14): 1335-1337.
5 April 2016
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.H., May, C., Wilck, N., Balogh, A., Ostermann, A.I., Schebb, N.H., Akkad, D.A., Grohme, D.A., Kleinewietfeld, M., Kempa, S., Thöne, J., Demir, S., Müller, D.N., Gold, R. and Linker, R.A.
Immunity 43
(4): 817-829.
20 October 2015
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47
(6): 647-653.
June 2015
Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.
Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K.J., Gebhardt, M., Heinig, M., Neubert, P., Fischer, F., Teufel, S., David, J.P., Neufert, C., Cavallaro, A., Rakova, N., Küper, C., Beck, F.X., Neuhofer, W., Muller, D.N., Schuler, G., Uder, M., Bogdan, C., Luft, F.C. and Titze, J.
Cell Metabolism 21
(3): 493-501.
3 March 2015
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H., Schröder, A., Neuhofer, W., Jantsch, J., Kopp, C., Karlsen, T.V., Boschmann, M., Goss, J., Bry, M., Rakova, N., Dahlmann, A., Brenner, S., Tenstad, O., Nurmi, H., Mervaala, E., Wagner, H., Beck, F.X., Müller, D.N., Kerjaschki, D., Luft, F.C., Harrison, D.G., Alitalo, K. and Titze, J.
Journal of Clinical Investigation 123
(7): 2803-2815.
1 July 2013
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187
(4): 387-396.
15 February 2013
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., Vassilieva, G., Lenkova, L., Johannes, B., Wabel, P., Moissl, U., Vienken, J., Gerzer, R., Eckardt, K.U., Müller, D.N., Kirsch, K., Morukov, B., Luft, F.C. and Titze, J.
Cell Metabolism 17
(1): 125-131.
8 January 2013
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Herse, F., LaMarca, B., Hubel, C.A., Kaartokallio, T., Lokki, A.I., Ekholm, E., Laivuori, H., Gauster, M., Huppertz, B., Sugulle, M., Ryan, M.J., Novotny, S., Brewer, J., Park, J.K., Kacik, M., Hoyer, J., Verlohren, S., Wallukat, G., Rothe, M., Luft, F.C., Muller, D.N., Schunck, W.H., Staff, A.C. and Dechend, R.
Circulation 126
(25): 2990-2999.
18 December 2012
A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G., Rump, A., Schulz, H., Stricker, S., Schulze, L., Platzer, K., Aydin, A., Tinschert, S., Goldring, M.B., Luft, F.C. and Bähring, S.
Journal of Clinical Investigation 122
(11): 3990-4002.
1 November 2012
Rats, salt, and history.
Luft, F.C.
Cell Metabolism 15
(2): 129-130.
8 February 2012
Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
Nickolas, T.L., Schmidt-Ott, K.M., Canetta, P., Forster, C., Singer, E., Sise, M., Elger, A., Maarouf, O., Sola-Del Valle, D.A., O'Rourke, M., Sherman, E., Lee, P., Geara, A., Imus, P., Guddati, A., Polland, A., Rahman, W., Elitok, S., Malik, N., Giglio, J., El-Sayegh, S., Devarajan, P., Hebbar, S., Saggi, S.J., Hahn, B., Kettritz, R., Luft, F.C. and Barasch, J.
Journal of the American College of Cardiology 59
(3): 246-255.
17 January 2012
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
Haufe, S., Engeli, S., Kast, P., Boehnke, J., Utz, W., Haas, V., Hermsdorf, M., Maehler, A., Wiesner, S., Birkenfeld, A.L., Sell, H., Otto, C., Mehling, H., Luft, F.C., Eckel, J., Schulz-Menger, J., Boschmann, M. and Jordan, J.
Hepatology 53
(5): 1504-1514.
May 2011
Pathophysiology and management of hypokalemia: a clinical perspective.
Unwin, R.J., Luft, F.C. and Shirley, D.G.
Nature Reviews Nephrology 7
(2): 75-84.
February 2011
The molecular and cellular identity of peripheral osmoreceptors.
Lechner, S.G., Markworth, S., Poole, K., Smith, E.S.J., Lapatsina, L., Frahm, S., May, M., Pischke, S., Suzuki, M., Ibanez-Tallon, I., Luft, F.C., Jordan, J. and Lewin, G.R.
Neuron 69
(2): 332-344.
27 January 2011
Divergent effects of central and peripheral renin on body weight and metabolism.
Luft, F.C.
Cell Metabolism 12
(5): 423-424.
3 November 2010
Novel baroreflex activation therapy in resistant hypertension results of a European multi-center feasibility study.
Scheffers, I.J., Kroon, A.A., Schmidli, J., Jordan, J., Tordoir, J.J., Mohaupt, M.G., Luft, F.C., Haller, H., Menne, J., Engeli, S., Ceral, J., Eckert, S., Erglis, A., Narkiewicz, K., Philipp, T. and de Leeuw, P.W.
Journal of the American College of Cardiology 56
(15): 1254-1258.
5 October 2010
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patients.
Munoz Saravia, S.G., Haberland, A., Bartel, S., Araujo, R., Valda, G., Duchen, D., Diaz Ramirez, I., Borges, A.C., Wallukat, G. and Schimke, I.
Journal of the American College of Cardiology 56
(6): 526-527.
3 August 2010
Cardiac involvement in sporadic inclusion-body myositis.
Utz, W., Schmidt, S., Schulz-Menger, J., Luft, F. and Spuler, S.
Circulation 121
(5): 706-708.
9 February 2010
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon their potential impact for early risk assessment in asymptomatic Chagas' patients.
Wallukat, G., Munoz Saravia, S.G., Haberland, A., Bartel, S., Araujo, R., Valda, G., Duchen, D., Diaz Ramirez, I., Borges, A.C. and Schimke, I.
Journal of the American College of Cardiology 55
(5): 463-468.
2 February 2010
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119
(22): 2904-2912.
9 June 2009
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.K., Beck, F.X., Mueller, D.N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., van Rooijen, N., Kurtz, A., Hilgers, K.F., Alitalo, K., Eckardt, K.U., Luft, F.C., Kerjaschki, D. and Titze, J.
Nature Medicine 15
(5): 545-552.
May 2009
BK channels in innate immune functions of neutrophils and macrophages.
Essin, K., Gollasch, M., Rolle, S., Weissgerber, P., Sausbier, M., Bohn, E., Autenrieth, I.B., Ruth, P., Luft, F.C., Nauseef, W.M. and Kettritz, R.
Blood 113
(6): 1326-1331.
5 February 2009
Angiogenesis factors and preeclampsia.
Dechend, R. and Luft, F.C.
Nature Medicine 14
(11): 1187-1188.
November 2008
Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
Gratze, P., Dechend, R., Stocker, C., Park, J.K., Feldt, S., Shagdarsuren, E., Wellner, M., Gueler, F., Rong, S., Gross, V., Obst, M., Plehm, R., Alenina, N., Zenclussen, A., Titze, J., Small, K., Yokota, Y., Zenke, M., Luft, F.C. and Mueller, D.N.
Circulation 117
(20): 2645-2656.
20 May 2008
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J., Fischer, J., Paskas, S., Heinig, M., Schulz, H., Goesele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., Gross, V., Hummel, O., Maatz, H., Patone, G., Saar, K., Vingron, M., Weldon, S.M., Lindpaintner, K., Hammock, B.D., Rohde, K., Dietz, R., Cook, S.A., Schunck, W.H., Luft, F.C. and Huebner, N.
Nature Genetics 40
(5): 529-537.
May 2008
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
von Vietinghoff, S., Tunnemann, G., Eulenberg, C., Wellner, M., Cardoso, M.C., Luft, F.C. and Kettritz, R.
Blood 109
(10): 4487-4493.
15 May 2007
Pseudo-pseudo Meigs' syndrome.
Schmitt, R., Weichert, W., Schneider, W., Luft, F.C. and Kettritz, R.
Lancet 366
: 1672.
5 November 2005
Plasma exchange for primary autoimmune autonomic failure.
Schroeder, C., Vernino, S., Birkenfeld, A.L., Tank, J., Heusser, K., Lipp, A., Benter, T., Lindschau, C., Kettritz, R., Luft, F.C. and Jordan, J.
New England Journal of Medicine 353
(15): 1585-1590.
13 October 2005
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.
Sausbier, M., Arntz, C., Bucurenciu, I., Zhao, H., Zhou, X.B., Sausbier, U., Feil, S., Kamm, S., Essin, K., Sailer, C.A., Abdullah, U., Krippeit-Drews, P., Feil, R., Hofmann, F., Knaus, H.G., Kenyon, C., Shipston, M.J., Storm, J.F., Neuhuber, W., Korth, M., Schubert, R., Gollasch, M. and Ruth, P.
Circulation 112
: 60-68.
5 July 2005
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection (authors reply inN Engl J Med. 2005 May 12;352(19):2027-8).
Dragun, D., Mueller, D.N., Braesen, J.H., Fritsche, L., Nieminen-Kelhae, M., Dechend, R., Kintscher, U., Rudolph, B., Hoebeke, J., Eckert, D., Mazak, I., Plehm, R., Schoenemann, C., Unger, T., Budde, K., Neumayer, H.H., Luft, F.C. and Wallukat, G.
New England Journal of Medicine 352
(6): 558-569.
1 January 2005
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Fiebeler, A., Nussberger, J., Shagdarsuren, E., Rong, S., Hilfenhaus, G., Al-Saadi, N., Dechend, R., Wellner, M., Meiners, S., Maser-Gluth, C., Jeng, A.Y., Webb, R.L., Luft, F.C. and Mueller, D.N.
Circulation 111
(23): 3087-3094.
1 January 2005
Paracrine role for periadventitial adipose tissue in the regulation of arterial tone.
Gollasch, M. and Dubrovska, G.
Trends in Pharmacological Sciences 25
: 647-653.
1 December 2004
Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells.
Mazak, I., Fiebeler, A., Muller, D.N., Park, J.K., Shagdarsuren, E., Lindschau, C., Dechend, R., Viedt, C., Pilz, B., Haller, H. and Luft, F.C.
Circulation 109
(22): 2792-2800.
8 June 2004
Axoplasmic importins enable retrograde injury signaling in lesioned nerve.
Hanz, S., Perlson, E., Willis, D., Zheng, J.Q., Massarwa, R., Huerta, J.J., Koltzenburg, M., Koehler, M., van Minnen, J., Twiss, J.L. and Fainzilber, M.
Neuron 40
(6): 1095-1104.
18 December 2003
Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M., Rolle, S., Wellner, M., Cardoso, M.C., Scheidereit, C., Luft, F.C. and Kettritz, R.
Blood 102
(6): 2259-2267.
15 September 2003
A splice mutation in a Syrian autosomal recessive hypercholesterolemia family causes a two-nucleotide deletion of mRNA.
Al Kateb, H., Bautz, E.K.F., Luft, F.C. and Bähring, S.
Circulation Research 93
(5): E49-E50.
5 September 2003
Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation.
Dechend, R., Gieffers, J., Dietz, R., Joerres, A., Rupp, J., Luft, F.C. and Maass, M.
Circulation 108
(3): 261-265.
22 July 2003
The renal arterial resistance index and renal allograft survival.
Radermacher, J., Mengel, M., Ellis, S., Stuht, S., Hiss, M., Schwarz, A., Eisenberger, U., Burg, M., Luft, F.C., Gwinner, W. and Haller, H.
New England Journal of Medicine 349
(2): 115-124.
10 July 2003
Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition.
Tank, J., Schroeder, C., Diedrich, A., Szczech, E., Haertter, S., Sharma, A.M., Luft, F.C. and Jordan, J.
Circulation 107
(23): 2949-2954.
17 June 2003
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase.
Dechend, R., Viedt, C., Mueller, D.N., Ugele, B., Brandes, R.P., Wallukat, G., Park, J.K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J. and Luft, F.C.
Circulation 107
(12): 1632-1639.
1 April 2003
Water drinking acutely improves orthostatic tolerance in healthy subjects.
Schroeder, C., Bush, V.E., Norcliffe, L.J., Luft, F.C., Tank, J., Jordan, J. and Hainsworth, R.
Circulation 106
(22): 2806-2811.
26 November 2002
Paradoxical effect of sibutramine on autonomic cardiovascular regulation.
Birkenfeld, A.L., Schroeder, C., Boschmann, M., Tank, J., Franke, G., Luft, F.C., Biaggioni, I., Sharma, A.M. and Jordan, J.
Circulation 106
(19): 2459-2465.
5 November 2002
Homocysteine and risk of ischemic heart disease and stroke - a meta-analysis.
JAMA: Journal of the American Medical Association 288
(16): 2015-2022.
23 October 2002
Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly).
Hoffmann, K., Dreger, C.K., Olins, A.L., Olins, D.E., Shultz, L.D., Lucke, B., Karl, H., Kaps, R., Mueller, D., Vaya, A., Aznar, J., Ware, R.E., Cruz, N.S., Lindner, T.H., Herrmann, H., Reis, A. and Sperling, K.
Nature Genetics 31
(4): 410-414.
August 2002
Catechol-O-methyltransferase and blood pressure in humans.
Jordan, J., Lipp, A., Tank, J., Schroeder, C., Stoffels, M., Franke, G., Diedrich, A., Arnold, G., Goldstein, D.S., Sharma, A.M. and Luft, F.C.
Circulation 106
(4): 460-465.
23 July 2002
Baroreflex buffering and susceptibility to vasoactive drugs.
Jordan, J., Tank, J., Shannon, J.R., Diedrich, A., Lipp, A., Schroeder, C., Arnold, G., Sharma, A.M., Biaggioni, I., Robertson, D. and Luft, F.C.
Circulation 105
(12): 1459-1464.
26 March 2002
Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance.
Schroeder, C., Tank, J., Boschmann, M., Diedrich, A., Sharma, A.M., Biaggioni, I., Luft, F.C. and Jordan, J.
Circulation 105
(3): 347-353.
22 January 2002
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice.
Drab, M., Verkade, P., Elger, M., Kasper, M., Lohn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F.C., Schedl, A., Haller, H. and Kurzchalia, T.V.
Science 293
(5539): 2449-2452.
28 September 2001
Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Dechend, R., Fiebeler, A., Park, J.K., Muller, D.N., Theuer, J., Mervaala, E., Bieringer, M., Gulba, D., Dietz, R., Luft, F.C. and Haller, H.
Circulation 104
: 576-581.
1 January 2001
Altered autonomic support of arterial blood pressure with age in healthy men.
Jones, P.P., Shapiro, L.F., Keisling, G.A., Jordan, J., Shannon, J.R., Quaife, R.A. and Seals, D.R.
Circulation 104
: 2424-2429.
1 January 2001
A region on chromosome 3 is linked to dizygotic twinning.
Busjahn, A., Knoblauch, H., Faulhaber, H.D., Aydin, A., Uhlmann, R., Tuomilehto, J., Kaprio, J., Jedrusik, P., Januszewicz, A., Strelau, J., Schuster, H., Luft, F.C. and Mueller-Myhsok, B.
Nature Genetics 26
(4): 398-399.
1 December 2000
Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact.
Jordan, J., Toka, H.R., Heusser, K., Toka, O., Shannon, J.R., Tank, J., Diedrich, A., Stabroth, C., Stoffels, M., Naraghi, R., Oelkers, W., Schuster, H., Schobel, H.P., Haller, H. and Luft, F.C.
Circulation 102
: 2611-2618.
21 November 2000
AT1 receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor.
Dechend, R., Homuth, V., Wallukat, G., Kreuzer, J., Park, J.K., Theuer, J., Juepner, A., Gulba, D.C., Mackman, N., Haller, H. and Luft, F.C.
Circulation 101
: 2382-2387.
23 May 2000
Dynamics of DNA replication factories in living cells.
Leonhardt, H., Rahn, H.P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D. and Cardoso, M.C.
Journal of Cell Biology 149
(2): 271-279.
17 April 2000
A cholesterol-lowering gene maps to chromosome 13q.
Knoblauch, H., Mueller-Myhsok, B., Busjahn, A., Avi, L.B., Bähring, S., Baron, H., Heath, S.C., Uhlmann, R., Faulhaber, H.D., Shpitzen, S., Aydin, A., Reshef, A., Rosenthal, M., Eliav, O., Muhl, A., Lowe, A., Schurr, D., Harats, D., Jeschke, E., Friedlander, Y., Schuster, H., Luft, F.C. and Leitersdorf, E.
American Journal of Human Genetics 66
(1): 157-166.
1 January 2000
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
Alternative splicing of human genes - more the rule than the exception?
Hanke, J., Brett, D., Zastrow, I., Aydin, A., Delbrueck, S., Lehmann, G., Luft, F.C., Reich, J. and Bork, P.
Trends in Genetics 15
: 389-390.
1 October 1999
Coma in a park.
Pilz, B., Mesner, C., Baetgen, S. and Luft, F.C.
Lancet 354
: 1090.
25 September 1999
Diagnosis of hemochromatosis.
Kalantar-Zadeh, K. and Luft, F.C.
Annals of Internal Medicine 131
(4): 311.
17 August 1999
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Wallukat, G., Homuth, V., Fischer, T., Lindschau, C., Horstkamp, B., Jupner, A., Baur, E., Nissen, E., Vetter, K., Neichel, D., Dudenhausen, J.W., Haller, H. and Luft, F.C.
Journal of Clinical Investigation 103
(7): 945-952.
1 April 1999
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3.
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I. and Willnow, T.E.
Cell 96
(4): 507-515.
19 February 1999
Cutting edge of cardiomyopathy.
Poepping, I., Thalhammer, C., Pilz, B. and Luft, F.C.
Lancet 32
(9139): 1518-1518.
7 November 1998
Families with autosomal dominant brachydactyly type E, short stature, and severe hypertension.
Toka, H.R., Bähring, S., Chitayat, D., Melby, J.C., Whitehead, R., Jeschke, E., Wienker, T.F., Toka, O., Schuster, H. and Luft, F.C.
Annals of Internal Medicine 129
(3): 204-208.
1 August 1998
Endothelial-cell permeability and protein kinase C in pre-eclampsia.
Haller, H., Hempel, A., Homuth, V., Mandelkow, A., Busjahn, A., Maasch, C., Drab, M., Lindschau, C., Juepner, A., Vetter, K., Dudenhausen, J. and Luft, F.C.
Lancet 351
(9107): 945-949.
28 March 1998
L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells.
Gollasch, M., Haase, H., Ried, C., Lindschau, C., Morano, I., Luft, F.C. and Haller, H.
FASEB Journal 12
: 593-601.
1 January 1998
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Deletion at 12p in a japanese child with brachydactyly overlaps the assigned locus of brachydactyly with hypertension in a turkish family.
Bähring, S., Nagai, T., Toka, H.R., Nitz, I., Toka, O., Aydin, A., Muhl, A., Wienker, T.F., Schuster, H. and Luft, F.C.
American Journal of Human Genetics 60
: 732-735.
1 January 1997
Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo.
Cardoso, M.C., Joseph, C., Rahn, H.P., Reusch, R., Nadal-Ginard, B. and Leonhardt, H.
Journal of Cell Biology 139
: 579-587.
1 January 1997
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
Gestational diabetes.
Knoblauch, H. and Luft, F.C.
Lancet 347
(9003): 759-760.
16 March 1996
Severe autosomal dominant hypertension and brachydactyly in a unique turkish kindred maps to human chromosome 12.
Schuster, H., Wienker, T.F., Bähring, S., Bilginturan, N., Toka, H.R., Neitzel, H., Jeschke, E., Toka, O., Gilbert, D., Lowe, A., Ott, J., Haller, H. and Luft, F.C.
Nature Genetics 13
(1): 98-100.
1 January 1996
Medical compared with surgical treatment for massive pulmonary embolism.
Gulba, D., Schmid, C., Borst, H.G., Lichtlen, P.R., Dietz, R. and Luft, F.C.
Lancet 343
(8897): 576-577.
5 March 1994
Lupianez, Dario (BIMSB)
Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.
Hurtado, A., Mota-Gómez, I., Lao, M., Real, F.M., Jedamzick, J., Burgos, M., Lupiáñez, D.G., Jiménez, R. and Barrionuevo, F.J.
Nature Communications 15
(1): 3809.
7 May 2024
Cancer evolution: a multifaceted affair.
Ciriello, G., Magnani, L., Aitken, S.J., Akkari, L., Behjati, S., Hanahan, D., Landau, D.A., Lopez-Bigas, N., Lupiáñez, D.G., Marine, J.C., Martin-Villalba, A., Natoli, G., Obenauf, A.C., Oricchio, E., Scaffidi, P., Sottoriva, A., Swarbrick, A., Tonon, G., Vanharanta, S. and Zuber, J.
Cancer Discovery 14
: 1-13.
January 2024
The little skate genome and the evolutionary emergence of wing-like fins.
Marlétaz, F., de la Calle-Mustienes, E., Acemel, R.D., Paliou, C., Naranjo, S., Martínez-García, P.M., Cases, I., Sleight, V.A., Hirschberger, C., Marcet-Houben, M., Navon, D., Andrescavage, A., Skvortsova, K., Duckett, P.Ed., González-Rajal, Á., Bogdanovic, O., Gibcus, J.H., Yang, L., Gallardo-Fuentes, L., Sospedra, I., Lopez-Rios, J., Darbellay, F., Visel, A., Dekker, J., Shubin, N., Gabaldón, T., Nakamura, T., Tena, J.J., Lupianez, D.G., Rokhsar, D.S. and Gómez-Skarmeta, J.L.
Nature 616
(7957): 495-503.
20 April 2023
Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert, R., Hetzel, S., Bailly, N., Haggerty, C., Ilik, I.A., Yung, P.Y.K., Navarro, C., Bolondi, A., Kumar, A.S., Anania, C., Brändl, B., Meierhofer, D., Lupianez, D.G., Müller, F.J., Aktas, T., Elsässer, S.J., Kretzmer, H., Smith, Z.D. and Meissner, A.
Nature Cell Biology 25
: 579–591.
April 2023
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C., Acemel, R.D., Jedamzick, J., Bolondi, A., Cova, G., Brieske, N., Kühn, R., Wittler, L., Real, F.M. and Lupiáñez, D.G.
Nature Genetics 54
(7): 1026-1036.
July 2022
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C, Daub, C.O., Lenhard, B. and Müller, F.
Nature Genetics 54
(7): 1037-1050.
July 2022
The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M., Haas, S.A., Franchini, P., Xiong, P., Simakov, O., Kuhl, H., Schöpflin, R., Heller, D., Moeinzadeh, M.H., Heinrich, V., Krannich, T., Bressin, A., Hartmann, M.F., Wudy, S.A., Dechmann, D.K.N., Hurtado, A., Barrionuevo, F.J., Schindler, M., Harabula, I., Osterwalder, M., Hiller, M., Wittler, L., Visel, A., Timmermann, B., Meyer, A., Vingron, M., Jiménez, R., Mundlos, S. and Lupiáñez, D.G.
Science 370
(6513): 208-214.
9 October 2020
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
Kragesteen, B.K., Spielmann, M., Paliou, C., Heinrich, V., Schöpflin, R., Esposito, A., Annunziatella, C., Bianco, S., Chiariello, A.M., Jerković, I., Harabula, I., Guckelberger, P., Pechstein, M., Wittler, L., Chan, Wi.L., Franke, M., Lupiáñez, D.G., Kraft, K., Timmermann, B., Vingron, M., Visel, A., Nicodemi, M., Mundlos, S. and Andrey, G.
Nature Genetics 50
(10): 1463-1473.
October 2018
Structural variation in the 3D genome.
Spielmann, M., Lupiáñez, D.G. and Mundlos, S.
Nature Reviews Genetics 19
(7): 453-467.
July 2018
Polymer physics predicts the effects of structural variants on chromatin architecture.
Bianco, S., Lupiáñez, D.G., Chiariello, A.M., Annunziatella, C., Kraft, K., Schöpflin, R., Wittler, L., Andrey, G., Vingron, M., Pombo, A., Mundlos, S. and Nicodemi, M.
Nature Genetics 50
(5): 662-667.
May 2018
Meier, Jochen
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A., Maggio, N., Eller, J., Caliskan, G., Semtner, M., Häussler, U., Jüttner, R., Dugladze, T., Smolinsky, B., Kowalczyk, S., Chronowska, E., Schwarz, G., Rathjen, F.G., Rechavi, G., Haas, C.A., Kulik, A., Gloveli, T., Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124
(2): 696-711.
3 February 2014
Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Juettner, R., More, M.I., Das, D., Babich, A., Meier, J., Henning, M., Erdmann, B., Mueller, E.C., Otto, A., Grantyn, R. and Rathjen, F.G.
Neuron 46
(2): 233-245.
21 May 2005
Mertins, Philipp (MDC/BIH)
Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O., Kirchner, M., Mertins, P., Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57
(9): 2140-2156.e10.
10 September 2024
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5
(8): 1267-1284.
August 2024
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I.V., Oelen, R., Groot, H.E., Benjamins, J.W., Brambs, S., Kaiser, R., Gottschlich, A., Hoffmann, G.V., Eivers, L., Martinez-Navarro, A., Bruns, N., Stiller, S., Akgöl, S., Yue, K., Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O., Kobold, S., Petzold, T., Zimmer, R., Enard, W., Saar, K., Mertins, P., Huebner, N., van der Harst, P., Franke, L.H., van der Wijst, M.G.P., Massberg, S., Heinig, M., Nicolai, L. and Stark, K.
Nature Medicine 30
(6): 1696-1710.
June 2024
Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15
(1): 2611.
23 March 2024
Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10
(12): eadl1710.
22 March 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Wang, Z., Shaabani, S., Gao, X., Ng, Y.L.D., Sapozhnikova, V., Mertins, P., Krönke, J. and Dömling, A.
Nature Communications 14
(1): 8437.
19 December 2023
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119
(18): 2902-2916.
December 2023
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37
(11): 2237-2249.
November 2023
Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
Schaupp, L., Addante, A., Völler, M., Fentker, K., Kuppe, A., Bardua, M., Duerr, J., Piehler, L., Röhmel, J., Thee, S., Kirchner, M., Ziehm, M., Lauster, D., Haag, R., Gradzielski, M., Stahl, M., Mertins, P., Boutin, S., Graeber, S.Y. and Mall, M.A.
European Respiratory Journal 62
(2): 2202153.
1 August 2023
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14
(1): 3936.
4 July 2023
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83
(6): 994-1011.e18.
16 March 2023
Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 11
(3): e006784.
14 March 2023
Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S., von Kügelgen, N., Dantsuji, S., Ron, M., Breimann, L., Baranovskii, A., Lödige, I., Kirchner, M., Fischer, M., Zerna, N., Bujanic, L., Mertins, P., Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26
(3): 394-405.
March 2023
Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132
(23): e160089.
1 December 2022
DNA methylation-based classification of sinonasal tumors.
Jurmeister, P., Glöß, S., Roller, R., Leitheiser, M., Schmid, S., Mochmann, L.H., Payá Capilla, E., Fritz, R., Dittmayer, C., Friedrich, C., Thieme, A., Keyl, P., Jarosch, A., Schallenberg, S., Bläker, H., Hoffmann, I., Vollbrecht, C., Lehmann, A., Hummel, M., Heim, D., Haji, M., Harter, P., Englert, B., Frank, S., Hench, J., Paulus, W., Hasselblatt, M., Hartmann, W., Dohmen, H., Keber, U., Jank, P., Denkert, C., Stadelmann, C., Bremmer, F., Richter, A., Wefers, A., Ribbat-Idel, J., Perner, S., Idel, C., Chiariotti, L., Della Monica, R., Marinelli, A., Schüller, U., Bockmayr, M., Liu, J., Lund, V.J., Forster, M., Lechner, M., Lorenzo-Guerra, S.L., Hermsen, M., Johann, P.D., Agaimy, A., Seegerer, P., Koch, A., Heppner, F., Pfister, S.M., Jones, D.T.W., Sill, M., von Deimling, A., Snuderl, M., Müller, K.R., Forgó, E., Howitt, B.E., Mertins, P., Klauschen, F. and Capper, D.
Nature Communications 13
(1): 7148.
28 November 2022
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K., Kirchner, M., Mertins, P., Zuberbier, T. and Babina, M.
Allergy 77
(11): 3337-3349.
November 2022
H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10
(10): e005535.
27 October 2022
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13
(1): 6407.
27 October 2022
Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
Pardo, M., Offer, S., Hartner, E., Di Bucchianico, S., Bisig, C., Bauer, S., Pantzke, J., Zimmermann, E.J., Cao, X., Binder, S., Kuhn, E., Huber, A., Jeong, S., Käfer, U., Schneider, E., Mesceriakovas, A., Bendl, J., Brejcha, R., Buchholz, A., Gat, D., Hohaus, T., Rastak, N., Karg, E., Jakobi, G., Kalberer, M., Kanashova, T., Hu, Y., Ogris, C., Marsico, A., Theis, F., Shalit, T., Gröger, T., Rüger, C.P., Oeder, S., Orasche, J., Paul, A., Ziehm, T., Zhang, Z.H., Adam, T., Sippula, O., Sklorz, M., Schnelle-Kreis, J., Czech, H., Kiendler-Scharr, A., Zimmermann, R. and Rudich, Y.
Environment International 166
: 107366.
August 2022
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13
(1): 4297.
25 July 2022
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H., Flórez, A.F., Kreth, S., Brückner, L.M., Yildiz, U., Gartlgruber, M., Odoni, D.I., Poschet, G., Garbowicz, K., Shao, C., Klein, C., Meier, J., Zeisberger, P., Nadler-Holly, M., Ziehm, M., Paul, F., Burhenne, J., Bell, E., Shaikhkarami, M., Würth, R., Stainczyk, S.A., Wecht, E.M., Kreth, J., Büttner, M., Ishaque, N., Schlesner, M., Nicke, B., Stresemann, C., Llamazares-Prada, M., Reiling, J.H., Fischer, M., Amit, I., Selbach, M., Herrmann, C., Wölfl, S., Henrich, K.O., Höfer, T., Trumpp, A. and Westermann, F.
Nature Cancer 3
(4): 471-485.
28 April 2022
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G., Conlon, T.M., Jeridi, A., Kim, R., Ertüz, Z., Lang, N.J., Ansari, M., Novikova, M., Jiang, D., Strunz, M., Gaianova, M., Hollauer, C., Gabriel, C., Angelidis, I., Doll, S., Pestoni, J.C., Edelmann, S.L., Kohlhepp, M.S., Guillot, A., Bassler, K., Van Eeckhoutte, H.P., Kayalar, Ö., Konyalilar, N., Kanashova, T., Rodius, S., Ballester-López, C., Genes Robles, C.M., Smirnova, N., Rehberg, M., Agarwal, C., Krikki, I., Piavaux, B., Verleden, S.E., Vanaudenaerde, B., Königshoff, M., Dittmar, G., Bracke, K.R., Schultze, J.L., Watz, H., Eickelberg, O., Stoeger, T., Burgstaller, G., Tacke, F., Heissmeyer, V., Rinkevich, Y., Bayram, H., Schiller, H.B., Conrad, M., Schneider, R. and Yildirim, A.Ö.
Nature Communications 13
(1): 1303.
14 March 2022
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13
(1): 1009.
23 February 2022
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L.E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J.C., Scherer, C., Rubio-Acero, R., Eser, T., Deák, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K., Tomas, L., Schulz, C., Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M., Iannacone, M., Zimmer, R., Mertins, P., Hubner, N., Hoelscher, M., Massberg, S., Stark, K. and Nicolai, L.
Nature Communications 13
(1): 1018.
23 February 2022
Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
Offer, S., Hartner, E., Di Bucchianico, S., Bisig, C., Bauer, S., Pantzke, J., Zimmermann, E.J., Cao, X., Binder, S., Kuhn, E., Huber, A., Jeong, S., Käfer, U., Martens, P., Mesceriakovas, A., Bendl, J., Brejcha, R., Buchholz, A., Gat, D., Hohaus, T., Rastak, N., Jakobi, G., Kalberer, M., Kanashova, T., Hu, Y., Ogris, C., Marsico, A., Theis, F., Pardo, M., Gröger, T., Oeder, S., Orasche, J., Paul, A., Ziehm, T., Zhang, Z.H., Adam, T., Sippula, O., Sklorz, M., Schnelle-Kreis, J., Czech, H., Kiendler-Scharr, A., Rudich, Y. and Zimmermann, R.
Environmental Health Perspectives 130
(2): 27003.
3 February 2022
CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N., Eckstein, J., Wallach, I., Nordmeyer, S., Kelm, M., Kirchner, M., Goubergrits, L., Schafstedde, M., Hennemuth, A., Kraus, M., Grune, T., Mertins, P., Kuehne, T. and Holzhütter, H.G.
Circulation 144
(24): 1926-1939.
14 December 2021
Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann, M., Gambara, G., Brzezicha, B., Popp, O., Pachmayr, E., Wedeken, L., Pflaume, A., Mokritzkij, M., Gül-Klein, S., Brandl, A., Schweiger-Eisbacher, C., Mertins, P., Hoffmann, J., Keilholz, U., Walther, W., Regenbrecht, C., Rau, B. and Stein, U.
Molecular Cancer 20
(1): 129.
21 October 2021
Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C., Schallenberg, S., Kirchner, M., Ziehm, M., Niquet, S., Haji, M., Beier, C., Neudecker, J., Klauschen, F. and Mertins, P.
Nature Communications 12
(1): 3576.
11 June 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W.
Cancer Research 81
(8): 2116-2127.
April 2021
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A., Sieverling, L., Nadler-Holly, M., Ziehm, M., Toprak, U.H., Herrmann, C., Ishaque, N., Okonechnikov, K., Gartlgruber, M., Park, Y.G., Wecht, E.M., Savelyeva, L., Henrich, K.O., Rosswog, C., Fischer, M., Hero, B., Jones, D.T.W., Pfaff, E., Witt, O., Pfister, S.M., Volckmann, Ri., Koster, J., Kiesel, K., Rippe, K., Taschner-Mandl, S., Ambros, P., Brors, B., Selbach, M., Feuerbach, L. and Westermann, F.
Nature Communications 12
(1): 1269.
24 February 2021
Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts.
Stegbauer, J., Kraus, M., Nordmeyer, S., Kirchner, M., Ziehm, M., Dommisch, H., Kelle, S., Kelm, M., Baczko, I., Landmesser, U., Tschope, C., Knosalla, C., Falcke, M., Schapranow, M.P., Regitz-Zagrosek, V., Mertins, P. and Kuehne, T.
Hypertension 76
(6): e41-e43.
December 2020
Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy.
Krug, K., Jaehnig, E.J., Satpathy, S., Blumenberg, L., Karpova, A., Anurag, M., Miles, G., Mertins, P., Geffen, Y., Tang, L.C., Heiman, D.I., Cao, S., Maruvka, Y.E., Lei, J.T., Huang, C., Kothadia, R.B., Colaprico, A., Birger, C., Wang, J., Dou, Y., Wen, B., Shi, Z., Liao, Y., Wiznerowicz, M., Wyczalkowski, M.A., Chen, X.S., Kennedy, J.J., Paulovich, A.G., Thiagarajan, M., Kinsinger, C.R., Hiltke, T., Boja, E.S., Mesri, M., Robles, A.I., Rodriguez, H., Westbrook, T.F., Ding, L., Getz, G., Clauser, K.R., Fenyö, D., Ruggles, K.V., Zhang, B., Mani, D.R, Carr, S.A., Ellis, M.J. and Gillette, M.A.
Cell 183
(5): 1436-1456.
25 November 2020
Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations.
Pandey, S., Gruenbaum, A., Kanashova, T., Mertins, P., Cluzel, P. and Chevrier, N.
Cell Systems 11
(5): 495-508.
18 November 2020
Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F., Fink, C., Hüttemeister, J., Kirchner, M., Radke, M.H., Lopez Carballo, J., Wagner, E., Kohl, T., Lehnart, S.E., Mertins, P. and Gotthardt, M.
Nature Communications 11
(1): 3133.
19 June 2020
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M., Rademacher, J., Bagshaw, R.D., Wortmann, C., Barth, C., van Unen, J., Alp, K.M., Giudice, G., Eccles, R.L., Heinrich, L.E., Pascual-Vargas, P., Sanchez-Castro, M., Brandenburg, L., Mbamalu, G., Tucholska, M., Spatt, L., Czajkowski, M.T., Welke, R.W., Zhang, S., Nguyen, V., Rrustemi, T., Trnka, P., Freitag, K., Larsen, B., Popp, O., Mertins, P., Gingras, A.C., Roth, F.P., Colwill, K., Bakal, C., Pertz, O., Pawson, T., Petsalaki, E. and Rocks, O.
Nature Cell Biology 22
(4): 498-511.
April 2020
Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D., Mani, D.C., Satpathy, S., Fereshetian, S., Gasser, J.A., Svinkina, T., Olive, M.E., Ebert, B.L., Mertins, P. and Carr, S.A.
Nature Communications 11
(1): 359.
17 January 2020
Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J., Mahnke, N.A., Hofman, Z.L.M., Maat, S.d., Wu, J., Bonnekoh, H., Pengelly, R.J., Ennis, S., Holloway, J.W., Kirchner, M., Mertins, P., Church, M.K., Maurer, M., Maas, C. and Krause, K.
Nature Communications 11
(1): 179.
10 January 2020
Phosphorylation of RAB7 by TBK1/IKKε regulates innate immune signaling in triple negative breast cancer.
Ritter, J.L., Zhu, Z., Thai, T.C., Mahadevan, N.R., Mertins, P., Knelson, E.H., Piel, B.P., Han, S., Jaffe, J.D., Carr, S.A., Barbie, D.A. and Barbie, T.U.
Cancer Research 80
(1): 44-56.
January 2020
Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
Lupberger, J., Croonenborghs, T., Roca Suarez, A.A., Van Renne, N., Jühling, F., Oudot, M.A., Virzì, A., Bandiera, S., Jamey, C., Meszaros, G., Brumaru, D., Mukherji, A., Durand, S.C., Heydmann, L., Verrier, E.R., El Saghire, H., Hamdane, N., Bartenschlager, R., Fereshetian, S., Ramberger, E., Sinha, R., Nabian, M., Everaert, C., Jovanovic, M., Mertins, P., Carr, S.A., Chayama, K., Dali-Youcef, N., Ricci, R., Bardeesy, N.M., Fujiwara, N., Gevaert, O., Zeisel, M.B., Hoshida, Y., Pochet, N. and Baumert, T.F.
Gastroenterology 157
(2): 537-551.
August 2019
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities.
Vasaikar, S., Huang, C., Wang, X., Petyuk, V.A., Savage, S.R., Wen, B., Dou, Y., Zhang, Y., Shi, Z., Arshad, O.A., Gritsenko, M.A., Zimmerman, L.J., McDermott, J.E., Clauss, T.R., Moore, R.J., Zhao, R., Monroe, M.E., Wang, Y.T., Chambers, M.C., Slebos, R.J.C., Lau, K.S., Mo, Q., Ding, L., Ellis, M., Thiagarajan, M., Kinsinger, C.R., Rodriguez, H., Smith, R.D., Rodland, K.D., Liebler, D.C., Liu, T. and Zhang, B.
Cell 177
(4): 1035-1049.
2 May 2019
The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37
(24): e98658.
14 December 2018
PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn, J.D., Miller, P.G., Silver, A.J., Sellar, R.S., Bhatt, S., Gibson, C., McConkey, M., Adams, D., Mar, B., Mertins, P., Fereshetian, S., Krug, K., Zhu, H., Letai, A., Carr, S.A., Doench, J., Jaiswal, S. and Ebert, B.L.
Blood 132
(11): 1095-1105.
13 September 2018
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S., Zhou, J., Liu, J.B., Wu, Z., Xu, X., Li, T., Xu, D., Schumacher, S.E., Puschhof, J., McFarland, J., Zou, C., Dulak, A., Henderson, L., Xu, P., O'Day, E., Rendak, R., Liao, W.L., Cecchi, F., Hembrough, T., Schwartz, S., Szeto, C., Rustgi, A.K., Wong, K.K., Diehl, J.A., Jensen, K., Graziano, F., Ruzzo, A., Fereshetian, S., Mertins, P., Carr, S.A., Beroukhim, R., Nakamura, K., Oki, E., Watanabe, M., Baba, H., Imamura, Y., Catenacci, D. and Bass, A.J.
Nature Medicine 24
(7): 968-977.
July 2018
CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Scholl, U.I., Stölting, G., Schewe, J., Thiel, A., Tan, H., Nelson-Williams, C., Vichot, A.A., Jin, S.C., Loring, E., Untiet, V., Yoo, T., Choi, J., Xu, S., Wu, A., Kirchner, M., Mertins, P., Rump, L.C., Onder, A.M., Gamble, C., McKenney, D., Lash, R.W., Jones, D.P., Chune, G., Gagliardi, P., Choi, M., Gordon, R., Stowasser, M., Fahlke, C. and Lifton, R.P.
Nature Genetics 50
(3): 349-354.
March 2018
Picky: a simple online PRM and SRM method designer for targeted proteomics.
Zauber, H., Kirchner, M. and Selbach, M.
Nature Methods 15
(3): 156-157.
28 February 2018
Metzger, Jakob (BIMSB)
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Meyer, Irmtraud (BIMSB)
e-RNA: a collection of web-servers for the prediction and visualisation of RNA secondary structure and their functional features.
Tsybulskyi, V., Semenchenko, E. and Meyer, I.M.
Nucleic Acids Research 51
(W1): W160-W167.
5 July 2023
CYCLeR - a novel tool for the full isoform assembly and quantification of circRNAs.
Stefanov, S.R. and Meyer, I.M.
Nucleic Acids Research 51
(2): e10.
25 January 2023
ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.
Tsybulskyi, V. and Meyer, I.M.
Nucleic Acids Research 50
(15): e85.
26 August 2022
CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo.
Martín, A.L., Mounir, M. and Meyer, I.M.
Nucleic Acids Research 49
(4): e19.
26 February 2021
R-chie: a web server and R package for visualizing cis and trans RNA-RNA, RNA-DNA and DNA-DNA interactions.
Tsybulskyi, V., Mounir, M. and Meyer, I.M.
Nucleic Acids Research 48
(18): e105.
9 October 2020
The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B., Wang, X., Eichelbaum, K., Sadewasser, A., Husic, I., Paki, K., Budt, M., Hergeselle, M., Vetter, B., Hou, J., Chen, W., Wiebusch, L., Meyer, I.M., Wolff, T. and Selbach, M.
Nature Communications 10
(1): 5518.
4 December 2019
Discovering novel hydrolases from hot environments.
Wohlgemuth, R., Littlechild, J., Monti, D., Schnorr, K., van Rossum, T., Siebers, B., Menzel, P., Kublanov, I.V., Rike, A.G., Skretas, G., Szabo, Z., Peng, X. and Young, M.J.
Biotechnology Advances 36
(8): 2077-2100.
December 2018
Morano, Ingo
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
4D visualization of replication foci in mammalian cells corresponding to individual replicons.
Chagin, V.O., Casas-Delucchi, C.S., Reinhart, M., Schermelleh, L., Markaki, Y., Maiser, A., Bolius, J.J., Bensimon, A., Fillies, M., Domaing, P., Rozanov, Y.M., Leonhardt, H. and Cardoso, M.C.
Nature Communications 7
: 11231.
7 April 2016
Photocontrol of contracting muscle fibers.
Hoppmann, C., Schmieder, P., Domaing, P., Vogelreiter, G., Eichhorst, J., Wiesner, B., Morano, I., Rueck-Braun, K. and Beyermann, M.
Angewandte Chemie International Edition 50
(33): 7699-7702.
8 August 2011
Smooth-muscle contraction without smooth-muscle myosin.
Morano, I., Chai, G.X., Baltas, L.G., Lamounier-Zepter, V., Lutsch, G., Kott, M., Haase, H. and Bader, M.
Nature Cell Biology 2
(6): 371-375.
1 June 2000
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells.
Gollasch, M., Haase, H., Ried, C., Lindschau, C., Morano, I., Luft, F.C. and Haller, H.
FASEB Journal 12
: 593-601.
1 January 1998
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Mueller, Dominik N. / Dechend, Ralph (MDC/ECRC)
High-sensitivity cardiac troponin I enhances preeclampsia prediction beyond maternal factors and the sFlt-1/PlGF ratio.
Bacmeister, L., Goßling, A., Buellesbach, A., Birukov, A., Myers, J.E., Thomas, S.T., Lee, S., Andersen, M.S., Jorgensen, J.S., Diemert, A., Blois, S.M., Arck, P.C., Hecher, K., Herse, F., Blankenberg, S., Dechend, R., Westermann, D. and Zeller, T.
Circulation 149
(2): 95-106.
9 January 2024
Autoantibodies against the chemokine receptor 3 predict cardiovascular risk.
Müller, F.S., Aherrahrou, Z., Grasshoff, H., Heidorn, M.W., Humrich, J.Y., Johanson, L., Aherrahrou, R., Reinberger, T., Schulz, A., Ten Cate, V., Robles, A.P., Koeck, T., Rapp, S., Lange, T., Brachaczek, L., Luebber, F., Erdmann, J., Heidecke, H., Schulze-Forster, K., Dechend, R., Lackner, K.J., Pfeiffer, N., Ghaemi Kerahrodi, J., Tüscher, O., Schwarting, A., Strauch, K., Münzel, T., Prochaska, J.H., Riemekasten, G. and Wild, P.S.
European Heart Journal 44
(47): 4935-4949.
14 December 2023
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Samuelsson, A.M., Bartolomaeus, T.U.P., Anandakumar, H., Thowsen, I., Nikpey, E., Han, J., Marko, L., Finne, K., Tenstad, O., Eckstein, J., Berndt, N., Kühne, T., Kedziora, S., Sultan, I., Skogstrand, T., Karlsen, T.V., Nurmi, H., Forslund, S.K., Bollano, E., Alitalo, K., Muller, D.N. and Wiig, H.
Cardiovascular Research 119
(7): 1553-1567.
4 July 2023
Salt sensitivity includes effects on immune cell signalling and metabolism.
Müller, D.N., Geisberger, S., Kleinewietfeld, M. and Jantsch, J.
Nature Reviews Immunology 23
(6): 341-342.
June 2023
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F., Hamad, I., Arroyo Hornero, R., Geisberger, S., Roels, J., Van Zeebroeck, L., Dyczko, A., van Gisbergen, M.W., Kurniawan, H., Wagner, A., Yosef, N., Weiss, S.N.Y., Schmetterer, K.G., Schröder, A., Krampert, L., Haase, S., Bartolomaeus, H., Hellings, N., Saeys, Y., Dubois, L.J., Brenner, D., Kempa, S., Hafler, D.A., Stegbauer, J., Linker, R.A., Jantsch, J., Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35
(2): 299-315.
7 February 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Endothelin antagonists and the quest for a new therapeutic option in resistant hypertension.
Dechend, R. and Delles, C.
Lancet 400
(10367): 1900-1901.
3 December 2022
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Gawałko, M., Agbaedeng, T.A., Saljic, A., Mueller, D.N., Wilck, N., Schnabel, R., Penders, J., Rienstra, M., van Gelder, I., Jespersen, T., Schotten, U., Crijns, H.J.G.M., Kalman, J.M., Sanders, P., Nattel, S., Dobrev, D. and Linz, D.
Cardiovascular Research 118
(11): 2415–2427.
July 2022
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O., Halpert, G., Schimke, L.F., Ostrinski, Y., Vojdani, A., Baiocchi, G.C., Freire, P.P., Filgueiras, I.S., Zyskind, I., Lattin, M.T., Tran, F., Schreiber, S., Marques, A.H.C., Plaça, D.R., Fonseca, D.L.M., Humrich, J.Y., Müller, A., Giil, L.M., Graßhoff, H., Schumann, A., Hackel, A., Junker, J., Meyer, C., Ochs, H.D., Lavi, Y.B., Scheibenbogen, C., Dechend, R., Jurisica, I., Schulze-Forster, K., Silverberg, J.I., Amital, H., Zimmerman, J., Heidecke, H., Rosenberg, A.Z., Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13
(1): 1220.
9 March 2022
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia, A., Zimmermann, F., Schumann, P., Jasina, A., Roessler, J., Schmidt, D., Heinze, P., Kaisler, J., Nageswaran, V., Aigner, A., Ceglarek, U., Cineus, R., Hegazy, A.N., van der Vorst, E.P.C., Döring, Y., Strauch, C.M., Nemet, I., Tremaroli, V., Dwibedi, C., Kränkel, N., Leistner, D.M., Heimesaat, M.M., Bereswill, S., Rauch, G., Seeland, U., Soehnlein, O., Müller, D.N., Gold, R., Bäckhed, F., Hazen, S.L., Haghikia, A. and Landmesser, U.
European Heart Journal 43
(6): ehab644.
7 February 2022
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Golic, M. and Kräker, K.
Diabetologia 64
(12): 2829-2842.
December 2021
Targeted diets for the gut microbiota and the potential cardiovascular effects.
Chiva-Blanch, G. and Mueller, D.N.
Cardiovascular Research 117
(11): e135–e137.
1 October 2021
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144
(2): 144-158.
13 July 2021
Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Huhn, K., Linz, P., Pemsel, F., Michalke, B., Seyferth, S., Kopp, C., Chaudri, M.A., Rothhammer, V., Dörfler, A., Uder, M., Nagel, A.M., Müller, D.N., Waschbisch, A., Lee, D.H., Bäuerle, T., Linker, R.A. and Haase, S.
Proceedings of the National Academy of Sciences of the United States of America 118
(28): e2102549118.
13 July 2021
Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort.
Birukov, A., Andersen, L.B., Andersen, M.S., Nielsen, J.H., Nielsen, F.g, Kyhl, H.B., Jørgensen, J.S., Grandjean, P., Dechend, R. and Jensen, T.K.
Environment International 151
: 106442.
June 2021
Sodium and its manifold impact on our immune system.
Jobin, K., Müller, D.N., Jantsch, J. and Kurts, C.
Trends in Immunology 42
(6): 469-479.
June 2021
Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E., Schewe, J., Zhang, J., Dinh, H.A., Forslund, S.K., Markó, L., Hellmig, N., Peters, J., Muller, D.N., Lifton, R.P., Nottoli, T., Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118
(17): e2014876118.
27 April 2021
The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K. and Muller, D.N.
Circulation Research 128
(7): 934-950.
2 April 2021
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12
(1): 1970.
30 March 2021
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
(3): 863-875.
1 March 2021
Will postnatal renin-angiotensin system blockade improve long-term maternal cardiovascular health after preeclampsia?
Staff, A.C. and Dechend, R.
Hypertension 76
(6): 1704-1706.
December 2020
Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.
Leistner, D.M., Kränkel, N., Meteva, D., Abdelwahed, Y.S., Seppelt, C., Stähli, B.E., Rai, H., Skurk, C., Lauten, A., Mochmann, H.C., Fröhlich, G., Rauch-Kröhnert, U., Flores, E., Riedel, M., Sieronski, L., Kia, S., Strässler, E., Haghikia, A., Dirks, F., Steiner, J. K., Mueller, D.N., Volk, H.D., Klotsche, J., Joner, M., Libby, P. and Landmesser, U.
European Heart Journal 41
(37): 3549-3560.
20 October 2020
Microscopy with undetected photons in the mid-infrared.
Kviatkovsky, I., Chrzanowski, H.M., Avery, E.G., Bartolomaeus, H. and Ramelow, S.
Science Advances 6
(42): eabd0264.
14 October 2020
Blood pressure and angiogenic markers in pregnancy: contributors to pregnancy-induced hypertension and offspring cardiovascular risk.
Birukov, A.., Herse, F., Nielsen, J.H., Kyhl, H.B., Golic, M., Kräker, K., Haase, N., Busjahn, A., Bruun, S., Jensen, B.L., Müller, D.N., Jensen, T.K., Christesen, H.T., Andersen, M.S., Jørgensen, J.S., Dechend, R. and Andersen, L.B.
Hypertension 76
(3): 901-909.
September 2020
Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142
(2): 133-149.
14 July 2020
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N., Foster, D.J., Cunningham, M.W., Bercher, J., Nguyen, T., Shulga-Morskaya, S., Milstein, S., Shaikh, S., Rollins, J., Golic, M., Herse, F., Kräker, K., Bendix, I., Serdar, M., Napieczynska, H., Heuser, A., Gellhaus, A., Thiele, K., Wallukat, G., Müller, D.N., LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130
(6): 2928-2942.
1 June 2020
Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H., Avery, E.G., Bartolomaeus, T.U.P., Kozhakhmetov, S., Zhumadilov, Z., Müller, D.N., Wilck, N., Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116
(7): 1252-1253.
June 2020
Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes.
Lekva, T., Sugulle, M., Moe, K., Redman, C., Dechend, R. and Staff, A.C.
Hypertension 75
(6): 1513-1522.
June 2020
Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A., Wiesemann, S., Golic, M., Balogh, A., Marko, L., Rakova, N., Wilck, N., Blaszczyk, E., Lim, C., Weiss, S., Kräker, K., Haase, N., Frolova, A., Jørgensen, J.S., Daub, S., Mueller, D.N., Herse, F., Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13
(5): 1291-1293.
May 2020
The (pro)renin receptor: what's in a name?
Simons, M., Bader, M. and Müller, D.N.
Nature Reviews Nephrology 16
(5): 304.
May 2020
B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116
(5): 1059-1070.
1 April 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G.I., Eilers, E., Bader, V., Haase, S., Kaisler, J., David, C., Schneider, R., Troisi, R., Zent, D., Hegelmaier, T., Dokalis, N., Gerstein, S., Del Mare-Roumani, S., Amidror, S., Staszewski, O., Poschmann, G., Stühler, K., Hirche, F., Balogh, A., Kempa, S., Träger, P., Zaiss, M.M., Holm, J.B., Massa, M.G., Nielsen, H.B., Faissner, A., Lukas, C., Gatermann, S.G., Scholz, M., Przuntek, H., Prinz, M., Forslund, S.K., Winklhofer, K.F., Müller, D.N., Linker, R.A., Gold, R. and Haghikia, A.
Cell 180
(6): 1067-1080.
19 March 2020
Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K., Jung, M., Foinquinos, A., San José, G., Beaumont, J., Bock, K., Grote-Levi, L., Xiao, K., Bär, C., Pfanne, A., Just, A., Zimmer, K., Ngoy, S., López, B., Ravassa, S., Samolovac, S., Janssen-Peters, H., Remke, J., Scherf, K., Dangwal, S., Piccoli, M.T., Kleemiss, F., Kreutzer, F.P., Kenneweg, F., Leonardy, J., Hobuß, L., Santer, L., Do, Q.T., Geffers, R., Braesen, J.H., Schmitz, J., Brandenberger, C., Müller, D.N., Wilck, N., Kaever, V., Bähre, H., Batkai, S., Fiedler, J., Alexander, K.M., Wertheim, B.M., Fisch, S., Liao, R., Diez, J., González, A. and Thum, T.
Circulation 141
(9): 751-767.
3 March 2020
Statins reverse postpartum cardiovascular dysfunction in a rat model of preeclampsia.
Kräker, K., O'Driscoll, J.M., Schütte, T., Herse, F., Patey, O., Golic, M., Geisberger, S., Verlohren, S., Birukov, A., Heuser, A., Mueller, D.N., Thilaganathan, B., Dechend, R. and Haase, N.
Hypertension 75
(1): 202-210.
January 2020
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Schewe, J., Seidel, E., Forslund, S., Marko, L., Peters, J., Muller, D.N., Fahlke, C., Stölting, G. and Scholl, U.
Nature Communications 10
(1): 5155.
14 November 2019
The role of sodium in modulating immune cell function.
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H. and Müller, D.N.
Nature Reviews Nephrology 15
(9): 546-558.
September 2019
The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution.
Taylor, D.M., Aronow, B.J., Tan, K., Bernt, K., Salomonis, N., Greene, C.S., Frolova, A., Henrickson, S.E., Wells, A., Pei, L., Jaiswal, J.K., Whitsett, J., Hamilton, K.E., MacParland, S.A., Kelsen, J., Heuckeroth, R.O., Potter, S.S., Vella, L.A., Terry, N.A., Ghanem, L.R., Kennedy, B.C., Helbig, I., Sullivan, K.E., Castelo-Soccio, L., Kreigstein, A., Herse, F., Nawijn, M.C., Koppelman, G.H., Haendel, M., Harris, N.L., Rokita, J.L., Zhang, Y., Regev, A., Rozenblatt-Rosen, O., Rood, J.E., Tickle, T.L, Vento-Tormo, R., Alimohamed, S., Lek, M., Mar, J.C., Loomes, K.M., Barrett, D.M., Uapinyoying, P., Beggs, A.H., Agrawal, P.B., Chen, Y.W., Muir, A.B., Garmire, L.X., Snapper, S.B., Nazarian, J., Seeholzer, S.H., Fazelinia, H., Singh, L.N., Faryabi, R.B., Raman, P., Dawany, N., Xie, H.M., Devkota, B., Diskin, S.J., Anderson, S.A., Rappaport, E.F., Peranteau, W., Wikenheiser-Brokamp, K.A., Teichmann, S., Wallace, D., Peng, T., Ding, Y.Y., Kim, M.S., Xing, Y., Kong, S.W., Bönnemann, C.G., Mandl, K.D. and White, P.S.
Developmental Cell 49
(1): 10-29.
8 April 2019
Sodium in the microenvironment regulates immune responses and tissue homeostasis.
Müller, D.N., Wilck, N., Haase, S., Kleinewietfeld, M. and Linker, R.A.
Nature Reviews Immunology 19
(4): 243-254.
April 2019
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.
Cabral-Marques, O., Marques, A., Giil, L.M., De Vito, R., Rademacher, J., Günther, J., Lange, T., Humrich, J.Y., Klapa, S., Schinke, S., Schimke, L.F., Marschner, G., Pitann, S., Adler, S., Dechend, R., Müller, D.N., Braicu, I., Sehouli, J., Schulze-Forster, K., Trippel, T., Scheibenbogen, C., Staff, A., Mertens, P.R., Löbel, M., Mastroianni, J., Plattfaut, C., Gieseler, F., Dragun, D., Engelhardt, B.E., Fernandez-Cabezudo, M.J., Ochs, H.D., Al-Ramadi, B.K., Lamprecht, P., Mueller, A., Heidecke, H. and Riemekasten, G.
Nature Communications 9
(1): 5224.
6 December 2018
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J., Luong, T.T., Tuffaha, R., Musculus, K., Auer, T., Lian, X., Daniel, C., Zickler, D., Boehme, B., Sacherer, M., Metzler, B., Kuhl, D., Gollasch, M., Amann, K., Müller, D.N., Pieske, B., Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128
(7): 3024-3040.
2 July 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J., Singh, M., Herse, F., Przybyl, L., Haase, N., Golic, M., Yung, H.W., Huppertz, B., Cartwright, J.E., Whitley, G.S., Johnsen, G.M., Levi, G., Isbruch, A., Schulz, H., Luft, F.C., Müller, D.N., Staff, A.C., Hurst, L.D., Dechend, R. and Izsvák, Z.
Circulation 136
(19): 1824-1839.
7 November 2017
High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K., Daub, S., Zhang, Y., Klein, J. D., Nakano, D., Pedchenko, T., Lantier, L., LaRocque, L.M., Marton, A., Neubert, P., Schröder, A., Rakova, N., Jantsch, J., Dikalova, A.E., Dikalov, S.I., Harrison, D.G., Müller, D.N., Nishiyama, A., Rauh, M., Harris, R. C., Luft, F.C., Wassermann, D.H., Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127
(5): 1944-1959.
1 May 2017
Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N., Kitada, K., Lerchl, K., Dahlmann, A., Birukov, A., Daub, S., Kopp, C., Pedchenko, T., Zhang, Y., Beck, L., Johannes, B., Marton, A., Müller, D.N., Rauh, M., Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127
(5): 1932-1943.
1 May 2017
CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L., Haase, N., Golic, M., Rugor, J., Solano, M.E., Arck, P.C., Gauster, M., Huppertz, B., Emontzpohl, C., Stoppe, C., Bernhagen, J., Leng, L., Bucala, R., Schulz, H., Heuser, A., Weedon-Fekjær, S., Johnsen, G.M., Peetz, D., Luft, F.C., Staff, A.C., Müller, D.N., Dechend, R. and Herse, F.
Circulation Research 119
(1): 55-68.
24 June 2016
High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J., Gebhardt, M., Heinig, M., Rintisch, C., Schroeder, A., Neuhofer, W., Hilgers, K., Manzel, A., Schwartz, C., Kleinewietfeld, M., Voelkl, J., Schatz, V., Linker, R.A., Lang, F., Voehringer, D., Wright, M.D., Hubner, N., Dechend, R., Jantsch, J., Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125
(11): 4223-4238.
2 November 2015
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.H., May, C., Wilck, N., Balogh, A., Ostermann, A.I., Schebb, N.H., Akkad, D.A., Grohme, D.A., Kleinewietfeld, M., Kempa, S., Thöne, J., Demir, S., Müller, D.N., Gold, R. and Linker, R.A.
Immunity 43
(4): 817-829.
20 October 2015
New role for the (pro)renin receptor in T cell development.
Geisberger, S., Maschke, U., Gebhardt, M., Kleinewietfeld, M., Manzel, A., Linker, R.A., Chidgey, A., Dechend, R., Nguyen, G., Daumke, O., Muller, D.N., Wright, M.D. and Binger, K.J.
Blood 126
(4): 504-507.
23 July 2015
Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.
Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K.J., Gebhardt, M., Heinig, M., Neubert, P., Fischer, F., Teufel, S., David, J.P., Neufert, C., Cavallaro, A., Rakova, N., Küper, C., Beck, F.X., Neuhofer, W., Muller, D.N., Schuler, G., Uder, M., Bogdan, C., Luft, F.C. and Titze, J.
Cell Metabolism 21
(3): 493-501.
3 March 2015
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H., Schröder, A., Neuhofer, W., Jantsch, J., Kopp, C., Karlsen, T.V., Boschmann, M., Goss, J., Bry, M., Rakova, N., Dahlmann, A., Brenner, S., Tenstad, O., Nurmi, H., Mervaala, E., Wagner, H., Beck, F.X., Müller, D.N., Kerjaschki, D., Luft, F.C., Harrison, D.G., Alitalo, K. and Titze, J.
Journal of Clinical Investigation 123
(7): 2803-2815.
1 July 2013
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R.A., Muller, D.N. and Hafler, D.A.
Nature 496
(7446): 518-522.
25 April 2013
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E.G., Wieghofer, P., Heinrich, A., Riemke, P., Hoelscher, C., Müller, D.N., Luckow, B., Brocker, T., Debowski, K., Fritz, G., Opdenakker, G., Diefenbach, A., Biber, K., Heikenwalder, M., Geissmann, F., Rosenbauer, F. and Prinz, M.
Nature Neuroscience 16
(3): 273-280.
March 2013
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., Vassilieva, G., Lenkova, L., Johannes, B., Wabel, P., Moissl, U., Vienken, J., Gerzer, R., Eckardt, K.U., Müller, D.N., Kirsch, K., Morukov, B., Luft, F.C. and Titze, J.
Cell Metabolism 17
(1): 125-131.
8 January 2013
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Herse, F., LaMarca, B., Hubel, C.A., Kaartokallio, T., Lokki, A.I., Ekholm, E., Laivuori, H., Gauster, M., Huppertz, B., Sugulle, M., Ryan, M.J., Novotny, S., Brewer, J., Park, J.K., Kacik, M., Hoyer, J., Verlohren, S., Wallukat, G., Rothe, M., Luft, F.C., Muller, D.N., Schunck, W.H., Staff, A.C. and Dechend, R.
Circulation 126
(25): 2990-2999.
18 December 2012
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119
(22): 2904-2912.
9 June 2009
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.K., Beck, F.X., Mueller, D.N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., van Rooijen, N., Kurtz, A., Hilgers, K.F., Alitalo, K., Eckardt, K.U., Luft, F.C., Kerjaschki, D. and Titze, J.
Nature Medicine 15
(5): 545-552.
May 2009
Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
Gratze, P., Dechend, R., Stocker, C., Park, J.K., Feldt, S., Shagdarsuren, E., Wellner, M., Gueler, F., Rong, S., Gross, V., Obst, M., Plehm, R., Alenina, N., Zenclussen, A., Titze, J., Small, K., Yokota, Y., Zenke, M., Luft, F.C. and Mueller, D.N.
Circulation 117
(20): 2645-2656.
20 May 2008
Subacute coronary stent thrombosis in cancer patients.
Gross, C.M., Posch, M.G., Geier, C., Olthoff, H., Kraemer, J., Dechend, R., Dietz, R. and Oezcelik, C.
Journal of the American College of Cardiology 51
(12): 1232-1233.
25 March 2008
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection (authors reply inN Engl J Med. 2005 May 12;352(19):2027-8).
Dragun, D., Mueller, D.N., Braesen, J.H., Fritsche, L., Nieminen-Kelhae, M., Dechend, R., Kintscher, U., Rudolph, B., Hoebeke, J., Eckert, D., Mazak, I., Plehm, R., Schoenemann, C., Unger, T., Budde, K., Neumayer, H.H., Luft, F.C. and Wallukat, G.
New England Journal of Medicine 352
(6): 558-569.
1 January 2005
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Fiebeler, A., Nussberger, J., Shagdarsuren, E., Rong, S., Hilfenhaus, G., Al-Saadi, N., Dechend, R., Wellner, M., Meiners, S., Maser-Gluth, C., Jeng, A.Y., Webb, R.L., Luft, F.C. and Mueller, D.N.
Circulation 111
(23): 3087-3094.
1 January 2005
Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells.
Mazak, I., Fiebeler, A., Muller, D.N., Park, J.K., Shagdarsuren, E., Lindschau, C., Dechend, R., Viedt, C., Pilz, B., Haller, H. and Luft, F.C.
Circulation 109
(22): 2792-2800.
8 June 2004
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase.
Dechend, R., Viedt, C., Mueller, D.N., Ugele, B., Brandes, R.P., Wallukat, G., Park, J.K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J. and Luft, F.C.
Circulation 107
(12): 1632-1639.
1 April 2003
Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Dechend, R., Fiebeler, A., Park, J.K., Muller, D.N., Theuer, J., Mervaala, E., Bieringer, M., Gulba, D., Dietz, R., Luft, F.C. and Haller, H.
Circulation 104
: 576-581.
1 January 2001
Mähler, Anja (ECRC)
Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104
(2): 388-393.
August 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Golic, M. and Kräker, K.
Diabetologia 64
(12): 2829-2842.
December 2021
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144
(2): 144-158.
13 July 2021
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12
(1): 1970.
30 March 2021
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
(3): 863-875.
1 March 2021
Na, Il-Kang (ECRC)
Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma.
Schmiester, M., Maier, R., Riedel, R., Durek, P., Frentsch, M., Kolling, S., Mashreghi, M.F., Jenq, R., Zhang, L., Peterson, C.B., Bullinger, L., Chang, H.D. and Na, I.K.
Gut Microbes 14
(1): e2081475.
29 May 2022
Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.
Mensen, A., Jöhrens, K., Anagnostopoulos, I., Demski, S., Oey, M., Stroux, A., Hemmati, P., Westermann, J., Blau, O., Wittenbecher, F., Movassaghi, K., Szyska, M., Thomas, S., Dörken, B., Scheibenbogen, C., Arnold, R. and Na, I.K.
Blood 124
(6): 963-972.
7 August 2014
Niendorf, Thoralf
Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
Haueise, T., Schick, F., Stefan, N., Schlett, C.L., Weiss, J.B., Nattenmüller, J., Göbel-Guéniot, K., Norajitra, T., Nonnenmacher, T., Kauczor, H.U., Maier-Hein, K.H., Niendorf, T., Pischon, T., Jöckel, K.H., Umutlu, L., Peters, A., Rospleszcz, S., Kröncke, T., Hosten, N., Völzke, H., Krist, L., Willich, S.N., Bamberg, F. and Machann, J.
Science Advances 9
(19): eadd0433.
12 May 2023
A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D.A., Blockx, I., Bortel, A., Broadwater, M., Cardoso, B.M., Célestine, M., Chavez-Negrete, J.E., Choi, S., Christiaen, E., Clavijo, P., Colon-Perez, L., Cramer, S., Daniele, T., Dempsey, E., Diao, Y., Doelemeyer, A., Dopfel, D., Dvořáková, L., Falfán-Melgoza, C., Fernandes, F.F., Fowler, C.F., Fuentes-Ibañez, A., Garin, C.M., Gelderman, E., Golden, C.E.M., Guo, C.C G., Henckens, M.J.A.G., Hennessy, L.A., Herman, P., Hofwijks, N., Horien, C., Ionescu, T.M., Jones, J., Kaesser, J., Kim, E., Lambers, H., Lazari, A., Lee, S.H., Lillywhite, A., Liu, Y., Liu, Y.Y., López-Castro, A., López-Gil, X., Ma, Z., MacNicol, E., Madularu, D., Mandino, F., Marciano, S., McAuslan, M.J., McCunn, P., McIntosh, A., Meng, X., Meyer-Baese, L., Missault, S., Moro, F., Naessens, D.M.P., Nava-Gomez, L.J., Nonaka, H., Ortiz, J.J., Paasonen, J., Peeters, L.M., Pereira, M., Perez, P.D., Pompilus, M., Prior, M., Rakhmatullin, R., Reimann, H.M., Reinwald, J., Del Rio, R.T., Rivera-Olvera, A., Ruiz-Pérez, D., Russo, G., Rutten, T.J., Ryoke, R., Sack, M., Salvan, P., Sanganahalli, B.G., Schroeter, A., Seewoo, B.J., Selingue, E., Seuwen, A., Shi, B., Sirmpilatze, N., Smith, J.A.B., Smith, C., Sobczak, F., Stenroos, P.J., Straathof, M., Strobelt, S., Sumiyoshi, A., Takahashi, K., Torres-García, M.E, Tudela, R., van den Berg, M., van der Marel, K., van Hout, A.T.B., Vertullo, R., Vidal, B., Vrooman, R.M., Wang, V.X., Wank, I., Watson, D.J.G., Yin, T., Zhang, Y., Zurbruegg, S., Achard, S., Alcauter, S., Auer, D.P., Barbier, E.L., Baudewig, J., Beckmann, C.F., Beckmann, N., Becq, G.J.P.C., Blezer, E.L.A., Bolbos, R., Boretius, S., Bouvard, S., Budinger, E., Buxbaum, J.D., Cash, D., Chapman, V., Chuang, K.H., Ciobanu, L., Coolen, B.F., Dalley, J.W., Dhenain, M., Dijkhuizen, R.M., Esteban, O., Faber, C., Febo, M., Feindel, K.W., Forloni, G., Fouquet, J., Garza-Villarreal, E.A., Gass, N., Glennon, J.C., Gozzi, A., Gröhn, O., Harkin, A., Heerschap, A., Helluy, X., Herfert, K., Heuser, A., Homberg, J.R., Houwing, D.J., Hyder, F., Ielacqua, G.D., Jelescu, I.O., Johansen-Berg, H., Kaneko, G., Kawashima, R., Keilholz, S.D., Keliris, G.A., Kelly, C., Kerskens, C., Khokhar, J.Y., Kind, P.C., Langlois, J.B., Lerch, J.P., López-Hidalgo, M.A, Manahan-Vaughan, D., Marchand, F., Mars, R.B., Marsella, G., Micotti, E., Muñoz-Moreno, E., Near, J., Niendorf, T., Otte, W.M., Pais-Roldán, P., Pan, W.J., Prado-Alcalá, R.A., Quirarte, G.L., Rodger, J., Rosenow, T., Sampaio-Baptista, C., Sartorius, A., Sawiak, S.J., Scheenen, T.W.J., Shemesh, N., Shih, Y.Y.I., Shmuel, A., Soria, G., Stoop, R., Thompson, G.J., Till, S.M., Todd, N., Van Der Linden, A., van der Toorn, A., van Tilborg, G.A.F, Vanhove, C., Veltien, A., Verhoye, M., Wachsmuth, L., Weber-Fahr, W., Wenk, P., Yu, X., Zerbi, V., Zhang, N., Zhang, B.B., Zimmer, L., Devenyi, G.A., Chakravarty, M.M. and Hess, A.
Nature Neuroscience 26
(4): 673-681.
April 2023
First in vivo fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod.
Starke, L., Millward, J.M., Prinz, C., Sherazi, F., Waiczies, H., Lippert, C., Nazaré, M., Paul, F., Niendorf, T. and Waiczies, S.
Theranostics 13
(4): 1217-1234.
5 February 2023
Radiofrequency induced heating of biodegradable orthopaedic screw implants during magnetic resonance imaging.
Espiritu, J., Berangi, M., Cwieka, H., Iskhakova, K., Kuehne, A., Florian Wieland, D.C., Zeller-Plumhoff, B., Niendorf, T., Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 25
: 86-94.
23 January 2023
Framework and baseline examination of the German National Cohort (NAKO).
Peters, A., Peters, A., Greiser, K.H., Göttlicher, S., Ahrens, W., Albrecht, M., Bamberg, F., Bärnighausen, T., Becher, H., Berger, K., Beule, A., Boeing, H., Bohn, B., Bohnert, K., Braun, B., Brenner, H., Bülow, R., Castell, S., Damms-Machado, A., Dörr, M., Ebert, N., Ecker, M., Emmel, C., Fischer, B., Franzke, C.W., Gastell, S., Giani, G., Günther, M., Günther, K., Günther, K.P., Haerting, J., Haug, U., Heid, I.M., Heier, M., Heinemeyer, D., Hendel, T., Herbolsheimer, F., Hirsch, J., Hoffmann, W., Holleczek, B., Hölling, H., Hörlein, A., Jöckel, K.H., Kaaks, R., Karch, A., Karrasch, S., Kartschmit, N., Kauczor, H.U., Keil, T., Kemmling, Y., Klee, B., Klüppelholz, B., Kluttig, A., Kofink, L., Köttgen, A., Kraft, D., Krause, G., Kretz, L., Krist, L., Kühnisch, J., Kuß, O., Legath, N., Lehnich, A.T., Leitzmann, M., Lieb, W., Linseisen, J., Loeffler, M., Macdonald, A., Maier-Hein, K.H., Mangold, N., Meinke-Franze, C., Meisinger, C., Melzer, J., Mergarten, B., Michels, K.B., Mikolajczyk, R., Moebus, S., Mueller, U., Nauck, M., Niendorf, T., Nikolaou, K., Obi, N., Ostrzinski, S., Panreck, L., Pigeot, I., Pischon, T., Pschibul-Thamm, I., Rathmann, W., Reineke, A., Roloff, S., Rujescu, D., Rupf, S., Sander, O., Schikowski, T., Schipf, S., Schirmacher, P., Schlett, C.L., Schmidt, B., Schmidt, G., Schmidt, M., Schöne, G., Schulz, H., Schulze, M.B., Schweig, A., Sedlmeier, A.M., Selder, S., Six-Merker, J., Sowade, R., Stang, A., Stegle, O., Steindorf, K., Stübs, G., Swart, E., Teismann, H., Thiele, I., Thierry, S., Ueffing, M., Völzke, H., Waniek, S., Weber, A., Werner, N., Wichmann, H.E., Willich, S.N., Wirkner, K., Wolf, K., Wolff, R., Zeeb, H., Zinkhan, M. and Zschocke, J.
European Journal of Epidemiology 37
(10): 1107-1124.
October 2022
Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J., Berangi, M., Yiannakou, C., Silva, E., Francischello, R., Kuehne, A., Niendorf, T., Könneker, S., Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15
: 382-391.
September 2022
An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Hahn, T., Ernsting, J., Winter, N.R., Holstein, V., Leenings, R., Beisemann, M., Fisch, L., Sarink, K., Emden, D., Opel, N., Redlich, R., Repple, J., Grotegerd, D., Meinert, S., Hirsch, J.G., Niendorf, T., Endemann, B., Bamberg, F., Kröncke, T., Bülow, R., Völzke, H., von Stackelberg, O., Sowade, R.F., Umutlu, L., Schmidt, B., Caspers, S., Kugel, H., Kircher, T., Risse, B., Gaser, C., Cole, J.H., Dannlowski, U. and Berger, K.
Science Advances 8
(1): eabg9471.
7 January 2022
In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Prinz, C., Starke, L., Millward, J.M., Fillmer, A., Delgado, P.R., Waiczies, H., Pohlmann, A., Rothe, M., Nazaré, M., Paul, F., Niendorf, T. and Waiczies, S.
Theranostics 11
(6): 2490-2504.
1 January 2021
Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Dusek, P., Mekle, R., Skowronska, M., Acosta-Cabronero, J., Huelnhagen, T., Robinson, S.D., Schubert, F., Deschauer, M., Els, A., Ittermann, B., Schottmann, G., Madai, V.I., Paul, F., Klopstock, T., Kmiec, T., Niendorf, T., Wuerfel, J. and Schneider, S.A.
Movement Disorders 35
(1): 142-150.
January 2020
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.
Feutlinske, F., Browarski, M., Ku, M.C., Trnka, P., Waiczies, S., Niendorf, T., Stallcup, W.B., Glass, R., Krause, E. and Maritzen, T.
Nature Communications 6
: 8535.
5 October 2015
Blood oxygen level-dependent magnetic resonance imaging in patients with stress-induced angina.
Friedrich, M.G., Niendorf, T., Schulz-Menger, J., Gross, C.M. and Dietz, R.
Circulation 108
(18): 2219-2223.
1 January 2003
Nuernberg, Peter
Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis.
Maerschenz, S., Endres, A.S., Brinckmann, A., Heise, T., Kristiansen, G., Nuernberg, P., Krueger, D.H., Guenther, S. and Meisel, H.
Gastroenterology 131
(3): 765-780.
September 2006
A genome-wide scan for attention-deficit/hyperactivity disorder in 155 german sib-pairs.
Hebebrand, J., Dempfle, A., Saar, K., Thiele, H., Herpertz-Dahlmann, B., Linder, M., Kiefl, H., Remschmidt, H., Hemminger, U., Warnke, A., Knoelker, U., Heiser, P., Friedel, S., Hinney, A., Schaefer, H., Nuernberg, P. and Konrad, K.
Molecular Psychiatry 11
(2): 196-205.
February 2006
NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.
Wojnowski, L., Kulle, B., Schirmer, M., Schlueter, G., Schmidt, A., Rosenberger, A., Vonhof, S., Bickeboeller, H., Toliat, M.R., Suk, E.K., Tzvetkov, M., Kruger, A., Seifert, S., Kloess, M., Hahn, H., Loeffler, M., Nuernberg, P., Pfreundschuh, M., Truemper, L., Brockmoeller, J. and Hasenfuss, G.
Circulation 112
(24): 3754-3762.
5 December 2005
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
Schumacher, J., Kaneva, R., Jamra, R.A., Diaz, G.O., Ohlraun, S., Milanova, V., Lee, Y.A., Rivas, F., Mayoral, F., Fuerst, R., Flaquer, A., Windemuth, C., Gay, E., Sanz, S., Gonzalez, M.J., Gil, S., Cabaleiro, F., del Rio, F., Perez, F., Haro, J., Kostov, C., Chorbov, V., Nikolova-Hill, A., Stoyanova, V., Onchev, G., Kremensky, I., Strauch, K., Schulze, T.G., Nuernberg, P., Gaebel, W., Klimke, A., Auburger, G., Wienker, T.F., Kalaydjieva, L., Propping, P., Cichon, S., Jablensky, A., Rietschel, M. and Noethen, M.M.
American Journal of Human Genetics 77
(6): 1102-1111.
1 December 2005
Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.
Hillmer, A.M., Hanneken, S., Ritzmann, S., Becker, T., Freudenberg, J., Brockschmidt, F.F., Flaquer, A., Freudenberg-Hua, Y., Jamra, R.A., Metzen, C., Heyn, U., Schweiger, N., Betz, R.C., Blaumeiser, B., Hampe, J., Schreiber, S., Schulze, T.G., Hennies, H.C., Schumacher, J., Propping, P., Ruzicka, T., Cichon, S., Wienker, T.F., Kruse, R. and Noethen, M.M.
American Journal of Human Genetics 77
(1): 140-148.
July 2005
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.
Metherell, L.A., Chapple, J.P., Cooray, S., David, A., Becker, C., Rueschendorf, F., Naville, D., Begeot, M., Khoo, B., Nuernberg, P., Huebner, A., Cheetham, M.E. and Clark, A.J.L.
Nature Genetics 37
(2): 166-170.
1 January 2005
Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.
Uhlenberg, B., Schuelke, M., Rueschendorf, F., Ruf, N., Kaindl, A.M., Henneke, M., Thiele, H., Stoltenburg-Didinger, G., Aksu, F., Topaloglu, H., Nuernberg, P., Huebner, C., Weschke, B. and Gaertner, J.
American Journal of Human Genetics 75
(2): 251-260.
August 2004
Allelic heterogeneity in the COH1 gene explains clinical variability in Cohen syndrome.
Hennies, H.C., Rauch, A., Seifert, W., Schumi, C., Moser, E., Al-Taji, E., Tariverdian, G., Chrzanowska, K.H., Krajewska-Walasek, M., Rajab, A., Giugliani, R., Neumann, T.E., Eckl, K.M., Karbasiyan, M., Reis, A. and Horn, D.
American Journal of Human Genetics 75
(1): 138-145.
July 2004
Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement.
Thiele, H., Sakano, M., Kitagawa, H., Sugahara, K., Rajab, A., Hoehne, W., Ritter, H., Leschik, G., Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 101
(27): 10155-10160.
23 June 2004
Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S., Probst, S., Gerull, B., Oechslin, E., Nuernberg, P., Heuser, A., Jenni, R., Hennies, H.C. and Thierfelder, L.
Circulation 109
(22): 2720-2723.
8 June 2004
Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4).
Donaudy, F., Snoeckx, R., Pfister, M., Zenner, H.P., Blin, N., Di Stazio, M., Ferrara, A., Lanzara, C., Ficarella, R., Declau, F., Pusch, C.M., Nuernberg, P., Melchionda, S., Zelante, L., Ballana, E., Estivill, X., Van Camp, G., Gasparini, P. and Savoia, A.
American Journal of Human Genetics 74
(4): 770-776.
April 2004
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy.
Janecke, A.R., Thompson, D.A., Utermann, G., Becker, C., Huebner, C.A., Schmid, E., McHenry, C.L., Nair, A.R., Rueschendorf, F., Heckenlively, J., Wissinger, B., Nuernberg, P. and Gal, A.
Nature Genetics 36
(8): 850-854.
1 January 2004
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
Lehmann, K., Seemann, P., Stricker, S., Sammar, M., Meyer, B., Suering, K., Majewski, F., Tinschert, S., Grzeschik, K.H., Mueller, D., Knaus, P., Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 100
(21): 12277-12282.
14 October 2003
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
Geier, C., Perrot, A., Ozcelik, C., Binner, P., Counsell, D., Hoffmann, K., Pilz, B., Martiniak, Y., Gehmlich, K., van der Ven, P.F.M., Furst, D.O., Vornwald, A., von Hodenberg, E., Nuernberg, P., Scheffold, T., Dietz, R. and Osterziel, K.J.
Circulation 107
(10): 1390-1395.
18 March 2003
Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.
Rutsch, F., Ruf, N., Vaingankar, S., Toliat, M.R., Suk, A., Hoehne, W., Schauer, G., Lehmann, M., Roscioli, T., Schnabel, D., Epplen, J.T., Knisely, A., Superti-Furga, A., McGill, J., Filippone, M., Sinaiko, A.R., Vallance, H., Hinrichs, B., Smith, W., Ferre, M., Terkeltaub, R. and Nuernberg, P.
Nature Genetics 34
(4): 379-381.
1 January 2003
A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution.
Otto, E., Hoefele, J., Ruf, R., Mueller, A.M., Hiller, K.S., Wolf, M.T.F., Schuermann, M.J., Becker, A., Birkenhaeger, R., Sudbrak, R., Hennies, H.C., Nuernberg, P. and Hildebrandt, F.
American Journal of Human Genetics 71
(5): 1161-1167.
November 2002
Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly).
Hoffmann, K., Dreger, C.K., Olins, A.L., Olins, D.E., Shultz, L.D., Lucke, B., Karl, H., Kaps, R., Mueller, D., Vaya, A., Aznar, J., Ware, R.E., Cruz, N.S., Lindner, T.H., Herrmann, H., Reis, A. and Sperling, K.
Nature Genetics 31
(4): 410-414.
August 2002
Mapping of gene loci for nephronophthisis type 4 and Senior-Loken syndrome, to chromosome 1p36.
Schuermann, M.J., Otto, E., Becker, A., Saar, K., Rueschendorf, F., Polak, B.C., Ala-Mello, S., Hoefele, J., Wiedensohler, A., Haller, M., Omran, H., Nuernberg, P. and Hildebrandt, F.
American Journal of Human Genetics 70
(5): 1240-1246.
May 2002
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
Hampe, J., Frenzel, H., Mirza, M.M., Croucher, P.J., Cuthbert, A., Mascheretti, S., Huse, K., Platzer, M., Bridger, S., Meyer, B., Nuernberg, P., Stokkers, P., Krawczak, M., Mathew, C.G., Curran, M. and Schreiber, S.
Proceedings of the National Academy of Sciences of the United States of America 99
(1): 321-326.
8 January 2002
A comprehensive linkage analysis for myocardial infarction and its related risk factors.
Broeckel, U., Hengstenberg, C., Mayer, B., Holmer, S., Martin, L.J., Comuzzie, A.G., Blangero, J., Nuernberg, P., Reis, A., Riegger, G.A.J., Jacob, H.J. and Schunkert, H.
Nature Genetics 30
: 210-214.
1 January 2002
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C., Schoser, B.G.H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.A., Nothen, M.M., Wienker, T.F., Malin, J.P., Propping, P., Reis, A., Mortier, W., Jentsch, T.J., Vorgerd, M. and Kubisch, C.
Nature Genetics 28
(3): 218-219.
July 2001
SPINK1 mutations in chronic pancreatitis.
Witt, H., Hennies, H.C. and Becker, M.
Gastroenterology 120
(4): 1060-1061.
March 2001
A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22.
Vanita, A., Singh, J.R., Sarhadi, V.K., Singh, D., Reis, A., Rueschendorf, F., Becker-Follmann, J., Jung, M. and Sperling, K.
American Journal of Human Genetics 68
(2): 509-514.
February 2001
Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1.
Grohmann, K., Schuelke, M., Diers, A., Hoffmann, K., Lucke, B., Adams, C., Bertini, E., Leonhardt-Horti, H., Muntoni, F., Ouvrier, R., Pfeufer, A., Rossi, R., Van Maldergem, L., Wilmshurst, J.M., Wienker, T.R., Sendtner, M., Rudnik-Schoeneborn, S., Zerres, K. and Huebner, C.
Nature Genetics 29
(1): 75-77.
1 January 2001
Identification, by homozygosity mapping, of a novel locus for autosomal recessive congenital ichthyosis on chromosome 17p, and evidence for further genetic heterogeneity.
Krebsova, A., Kuester, W., Lestringant, G.G., Schulze, B., Hinz, B., Frossard, P.M., Reis, A. and Hennies, H.C.
American Journal of Human Genetics 69
(1): 216-222.
1 January 2001
A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3.
Leal, A., Morera, B., del Valle, G., Heuss, D., Kayser, C., Berghoff, M., Villegas, R., Hernandez, E., Mendez, M., Hennies, H.C., Neundoerfer, B., Barrantes, R., Reis, A. and Rautenstrauss, B.
American Journal of Human Genetics 68
: 269-274.
1 January 2001
Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.
Nuernberg, P., Thiele, H., Chandler, D., Hoehne, W., Cunningham, M.L., Ritter, H., Leschik, G., Uhlmann, K., Mischung, C., Harrop, K., Goldblatt, J., Borochowitz, Z.U., Kotzot, D., Westermann, F., Mundlos, S., Braun, H.S., Laing, N. and Tinschert, S.
Nature Genetics 28
(1): 37-41.
1 January 2001
Paternal relatedness and age proximity regulate social relationships among adult female rhesus macaques.
Widdig, A., Nuernberg, P., Krawczak, M., Streich, W.J. and Bercovitch, F.B.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13769-13773.
1 January 2001
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee, Y.A., Wahn, U., Kehrt, R., Tarani, L., Businco, L., Gustafsson, D., Andersson, F., Oranje, A.P., Wolkertstorfer, A., von Berg, A., Hoffmann, U., Kuester, W., Wienker, T.F., Rueschendorf, F. and Reis, A.
Nature Genetics 26
: 470-473.
1 December 2000
Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15.
Stoeber, G., Saar, K., Rueschendorf, F., Meyer, J., Nuernberg, G., Jatzke, S., Franzek, E., Reis, A., Lesch, K.P., Wienker, T.F. and Beckmann, H.
American Journal of Human Genetics 67
: 1201-1207.
1 November 2000
Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Lee, Y.A., Rueschendorf, F., Windemuth, C., Schmitt-Egenolf, M., Stadelmann, A., Nuernberg, G., Staender, M., Wienker, T.F., Reis, A. and Traupe, H.
American Journal of Human Genetics 67
(4): 1020-1024.
1 October 2000
Localization of a gene for syndactyly type 1 to chromosome 2q34-q36.
Bosse, K., Betz, R.C., Lee, Y.A., Wienker, T.F., Reis, A., Kleen, H., Propping, P., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 67
: 492-497.
1 August 2000
Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E. and Balling, R.
Nature Genetics 25
: 444-447.
1 August 2000
A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
Betz, R.C., Lee, Y.A., Bygum, A., Brandrup, F., Bernal, A.I., Toribio, J., Alvarez, J.I., Kukuk, G.M., Ibsen, H.H.W., Rasmussen, H.B., Wienker, T.F., Reis, A., Propping, P., Kruse, R., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 66
: 1979-1983.
1 June 2000
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis.
Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., Landt, O. and Becker, M.
Nature Genetics 25
(2): 213-216.
1 June 2000
A gene for an autosomal dominant scleroatrophic syndrome predisposing to skin cancer (Huriez Syndrome) maps to chromosome 4q23.
Lee, Y.A., Stevens, H.P., Delaporte, E., Wahn, U. and Reis, A.
American Journal of Human Genetics 66
: 326-330.
1 January 2000
Identification of a new gene locus for adolescent nephronophthisis, on chromosome 3q22 in a large venezuelan pedigree.
Omran, H., Fernandez, C., Jung, M., Haeffner, K., Fargier, B., Villaquiran, A., Waldherr, R., Gretz, N., Brandis, M., Rueschendorf, F., Reis, A. and Hildebrandt, F.
American Journal of Human Genetics 66
(1): 118-127.
1 January 2000
Homozygosity mapping in families with Joubert syndrome identifies a locus on chromosome 9q34.3 and evidence for genetic heterogeneity.
Saar, K., Al-Gazali, L., Sztriha, L., Rueschendorf, F., Nur-E-Kamal, M., Reis, A. and Bayoumi, R.
American Journal of Human Genetics 65
: 1666-1671.
1 December 1999
Diaphragmatic spinal muscular atrophy with respiratory distress is heterogeneous, and one form is linked to chromosome 11q13-q21.
Grohmann, K., Wienker, T.F., Saar, K., Rudnik-Schoeneborn, S., Stoltenburg-Didinger, G., Rossi, R., Novelli, G., Nuernberg, G., Pfeufer, A., Wirth, B., Reis, A., Zerres, K. and Huebner, C.
American Journal of Human Genetics 65
: 1459-1462.
1 November 1999
Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B.
Bittner, R.E., Anderson, L.V.B., Burkhardt, E., Bashir, R., Vafiadaki, E., Ivanova, S., Raffelsberger, T., Maerk, I., Hoeger, H., Jung, M., Karbasiyan, M., Storch, M., Lassmann, H., Moss, J.A., Davison, K., Harrison, R., Bushby, K.M.D. and Reis, A.
Nature Genetics 23
: 141-142.
1 October 1999
Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22.
Jung, M., Poepping, I., Perrot, A., Ellmer, A.E., Wienker, T.F., Dietz, R., Reis, A. and Osterziel, K.J.
American Journal of Human Genetics 65
(4): 1068-1077.
October 1999
The Fanconi anemia group E gene, FANCE, maps to chromosome 6p.
Waisfisz, Q., Saar, K., Morgan, N.V., Altay, C., Leegwater, P.A., de Winter, J.P., Komatsu, K., Evans, G.R., Wegner, R.D., Reis, A., Joenje, H., Arwert, F., Mathew, C.G., Pronk, J.C. and Digweed, M.
American Journal of Human Genetics 64
: 1400-1405.
1 May 1999
Limb mammary syndrome: A new genetic disorder with mammary hypoplasia, ectrodactyly, and other hand/foot anomalies maps to human chromosome 3q27.
van Bokhoven, H., Jung, M., Smits, A.P.T., van Beersum, S., Rueschendorf, F., van Steensel, M., Veenstra, M., Tuerlings, J.H.A.M., Mariman, E.C.M., Brunner, H.G., Wienker, T.F., Reis, A., Ropers, H.H. and Hamel, B.C.J.
American Journal of Human Genetics 64
(2): 538-546.
February 1999
Hereditary isolated renal magnesium loss maps to chromosome 11q23.
Meij, I.C., Saar, K., van den Heuvel, L.P.W.J., Nuernberg, G., Vollmer, M., Hildebrandt, F., Reis, A., Monnens, L.A.H. and Knoers, N.V.A.M.
American Journal of Human Genetics 64
: 180-188.
1 January 1999
The gene for human fibronectin glomerulopathy maps to 1q32, in the region of the regulation of complement activation gene cluster.
Vollmer, M., Jung, M., Rueschendorf, F., Ruf, R., Wienker, T.F., Reis, A., Krapf, R. and Hildebrandt, F.
American Journal of Human Genetics 63
(6): 1724-1731.
December 1998
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta 1 subunit gene SCN1B.
Wallace, R.H., Wang, D.W., Singh, R., Scheffer, I.E., George, A.L., Phillips, H.A., Saar, K., Reis, A., Johnson, E.W., Sutherland, G.R., Berkovic, S.F. and Mulley, J.C.
Nature Genetics 19
(4): 366-370.
1 August 1998
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.
Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K.M., Chrzanowska, K.H., Saar, K., Beckmann, G., Seemanova, E., Cooper, P.R., Nowak, N.J., Stumm, M., Weemaes, C.M.R., Gatti, R.A., Wilson, R.K., Digweed, M., Rosenthal, A., Sperling, K., Concannon, P. and Reis, A.
Cell 93
(3): 467-476.
1 May 1998
Gene localization for an autosomal dominant familial periodic fever to 12p13.
Mulley, J., Saar, K., Hewitt, G., Rueschendorf, F., Phillips, H., Colley, A., Sillence, D., Reis, A. and Wilson, M.
American Journal of Human Genetics 62
(4): 884-889.
April 1998
Nearby stop codons in exons of the neurofibromatosis type 1 gene are disparate splice effectors.
Hoffmeyer, S., Nuernberg, P., Ritter, H., Fahsold, R., Leistner, W., Kaufmann, D. and Krone, W.
American Journal of Human Genetics 62
(2): 269-277.
6 February 1998
The gene for autosomal dominant craniometaphyseal dysplasia maps to chromosome 5p and is distinct from the growth hormone receptor gene.
Nuernberg, P., Tinschert, S., Mrug, M., Hampe, J., Mueller, C.R., Fuhrmann, E., Braun, H.S. and Reis, A.
American Journal of Human Genetics 61
(4): 918-923.
October 1997
Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in south african afrikaans-speakers.
Starfield, M., Hennies, H.C., Jung, M., Jenkins, T., Wienker, T.F., Hull, P., Spurdle, A., Kuester, W., Ramsay, M. and Reis, A.
American Journal of Human Genetics 61
(2): 370-378.
August 1997
The gene for the ataxia telangiectasia variant, nijmegen breakage syndrome, maps to a 1 cm interval on chromosome 8q21.
Saar, K., Chrzanowska, K.H., Stumm, M., Jung, M., Nuernberg, G., Wienker, T.F., Seemanova, E., Wegner, R.D., Reis, A. and Sperling, K.
American Journal of Human Genetics 60
(3): 605-610.
March 1997
Obermayer, Benedikt
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M., Solana, J., Wolf, F.A., Ayoub, S., Misios, A., Glažar, P., Obermayer, B., Theis, F.J., Kocks, C. and Rajewsky, N.
Science 360
(6391): eaaq1723.
25 May 2018
Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L., Mukherjee, N., Wyler, E., Zauber, H., Hirsekorn, A., Selbach, M., Landthaler, M., Obermayer, B. and Ohler, U.
Nature Methods 13
(2): 165-170.
February 2016
Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M. and Obermayer, B.
Genome Biology 16
: 179.
14 September 2015
Mixed messages: re-initiation factors regulate translation of animal mRNAs.
Obermayer, B. and Rajewsky, N.
Cell Research 24
(12): 1383-1384.
December 2014
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.
Bazzini, A.A., Johnstone, T.G., Christiano, R., Mackowiak, S.D., Obermayer, B., Fleming, E.S., Vejnar, C.E., Lee, M.T., Rajewsky, N., Walther, T.C. and Giraldez, A.J.
EMBO Journal 33
(9): 981-993.
2 May 2014
Oertel, Frederike Cosima (ECRC)
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.
Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J.I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J.P., Zimmermann, H.G., Oertel, F.C., Ringelstein, M., Brandt, A.U., Paul, F., Aktas, O., Hartung, H.P., Wiendl, H., Meuth, S.G. and Albrecht, P.
Nature Communications 15
(1): 5243.
19 June 2024
Ohler, Uwe (BIMSB)
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.
Puttick, C., Jones, T.P., Leung, M.M., Galvez-Cancino, F., Liu, J., Varas-Godoy, M., Rowan, A., Pich, O., Martinez-Ruiz, C., Bentham, R., Dijkstra, K.K., Black, J.R.M., Rosenthal, R., Kanu, N., Litchfield, K., Salgado, R., Moore, D.A., Van Loo, P., Jamal-Hanjani, M., Quezada, S.A., Swanton, C. and McGranahan, N.
Nature Genetics 56
(10): 2121-2131.
October 2024
Liam tackles complex multimodal single-cell data integration challenges.
Rautenstrauch, P. and Ohler, U.
Nucleic Acids Research 52
(12): e52.
8 July 2024
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
Tiniakou, I., Hsu, P.F., Lopez-Zepeda, L.S., Garipler, G., Esteva, E., Adams, N.M., Jang, G., Soni, C., Lau, C.M., Liu, F., Khodadadi-Jamayran, A., Rodrick, T.C., Jones, D., Tsirigos, A., Ohler, U., Bedford, M.T., Nimer, S.D., Kaartinen, V., Mazzoni, E.O. and Reizis, B.
Science Immunology 9
(94): eadi1023.
12 April 2024
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma.
Pan, X., AbdulJabbar, K., Coelho-Lima, J., Grapa, A.I., Zhang, H., Cheung, A.H.K., Baena, J., Karasaki, T., Wilson, C.R., Sereno, M., Veeriah, S., Aitken, S.J., Hackshaw, A., Nicholson, A.G., Jamal-Hanjani, M., Swanton, C., Yuan, Y., Le Quesne, J. and Moore, D.A.
Nature Cancer 5
(2): 347-363.
February 2024
Genomic–transcriptomic evolution in lung cancer and metastasis.
Martínez-Ruiz, C., Black, J.R.M., Puttick, C., Hill, M.S., Demeulemeester, J., Larose Cadieux, E., Thol, K., Jones, T.P., Veeriah, S., Naceur-Lombardelli, C., Toncheva, A., Prymas, P., Rowan, A., Ward, S., Cubitt, L., Athanasopoulou, F., Pich, O., Karasaki, T., Moore, D.A., Salgado, R., Colliver, E., Castignani, C., Dietzen, M., Huebner, A., Al Bakir, M., Tanić, M., Watkins, T.B.K., Lim, E.L., Al-Rashed, A.M., Lang, D., Clements, J., Cook, D.E., Rosenthal, R., Wilson, G. A., Frankell, A.M., de Carné Trécesson, S., East, P., Kanu, N., Litchfield, K., Birkbak, N.J., Hackshaw, A., Beck, S., Van Loo, P., Jamal-Hanjani, M., McGranahan, N. and Swanton, C.
Nature 616
(7957): 543-552.
20 April 2023
Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng, K.W., Boumelha, J., Enfield, K.S.S., Almagro, J., Cha, H., Pich, O., Karasaki, T., Moore, D.A., Salgado, R., Sivakumar, M., Young, G., Molina-Arcas, M., de Carné Trécesson, S., Anastasiou, P., Fendler, A., Au, L., Shepherd, S.T.C., Martínez-Ruiz, C., Puttick, C., Black, J.R.M., Watkins, T.B.K., Kim, H., Shim, S., Faulkner, N., Attig, J., Veeriah, S., Magno, N., Ward, S., Frankell, A.M., Al Bakir, M., Lim, E.L., Hill, M.S., Wilson, G.A., Cook, D.E., Birkbak, N.J., Behrens, A., Yousaf, N., Popat, S., Hackshaw, A., Hiley, C.T., Litchfield, K., McGranahan, N., Jamal-Hanjani, M., Larkin, J., Lee, S.H., Turajlic, S., Swanton, C., Downward, J. and Kassiotis, G.
Nature 616
(7957): 563-573.
20 April 2023
Lung adenocarcinoma promotion by air pollutants.
Hill, W., Lim, E.L., Weeden, C.E., Lee, C., Augustine, M., Chen, K., Kuan, F.C., Marongiu, F., Evans, E.J., Moore, D.A., Rodrigues, F.S., Pich, O., Bakker, B., Cha, H., Myers, R., van Maldegem, F., Boumelha, J., Veeriah, S., Rowan, A., Naceur-Lombardelli, C., Karasaki, T., Sivakumar, M., De, S., Caswell, D.R., Nagano, A., Black, J.R.M., Martínez-Ruiz, C., Ryu, M.H., Huff, R.D., Li, S., Favé, M.J., Magness, A., Suárez-Bonnet, A., Priestnall, S.L., Lüchtenborg, M., Lavelle, K., Pethick, J., Hardy, S., McRonald, F.E., Lin, M.H., Troccoli, C.I., Ghosh, M., Miller, Y.E., Merrick, D.T., Keith, R.L., Al Bakir, M., Bailey, C., Hill, M.S., Saal, L.H., Chen, Y., George, A.M., Abbosh, C., Kanu, N., Lee, S.H., McGranahan, N., Berg, C.D., Sasieni, P., Houlston, R., Turnbull, C., Lam, S., Awadalla, P., Grönroos, E., Downward, J., Jacks, T., Carlsten, C., Malanchi, I., Hackshaw, A., Litchfield, K., DeGregori, J., Jamal-Hanjani, M. and Swanton, C.
Nature 616
(7955): 159-167.
6 April 2023
Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root.
Nolan, T.M., Vukašinović, N., Hsu, C.W., Zhang, J., Vanhoutte, I., Shahan, R., Taylor, I.W., Greenstreet, L., Heitz, M., Afanassiev, A., Wang, P., Szekely, P., Brosnan, A., Yin, Y., Schiebinger, G., Ohler, U., Russinova, E. and Benfey, P.N.
Science 379
(6639): eadf4721.
31 March 2023
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19.
Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.C., Liu, Z., Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.J., Cornberg, M., Schulte, L.N. and Li, Y.
Cell Genomics 3
(2): 100232.
8 February 2023
A critical period of translational control during brain development at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29
(12): 1277-1290.
December 2022
Cluster-independent marker feature identification from single-cell omics data using SEMITONES.
Vlot, A.H.C., Maghsudi, S. and Ohler, U.
Nucleic Acids Research 50
(18): e107.
14 October 2022
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
Poetz, F., Lebedeva, S., Schott, J., Lindner, D., Ohler, U. and Stoecklin, G.
Genome Biology 23
(1): 193.
12 September 2022
Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R., Rautenstrauch, P., Ghanbari, M., James, A.R., Kirchler, M., Ohler, U., Konigorski, S. and Lippert, C.
Nature Communications 13
(1): 5332.
10 September 2022
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C, Daub, C.O., Lenhard, B. and Müller, F.
Nature Genetics 54
(7): 1037-1050.
July 2022
Standardized annotation of translated open reading frames.
Mudge, J.M., Ruiz-Orera, J., Prensner, J.R., Brunet, M.A., Calvet, F., Jungreis, I., Gonzalez, Jo.M., Magrane, M., Martinez, T.F., Schulz, J.F., Yang, Y.T., Albà, M.M., Aspden, J.L., Baranov, P.V., Bazzini, A.A., Bruford, E., Martin, M.J., Calviello, L., Carvunis, A.R., Chen, J., Couso, J.P., Deutsch, E.W., Flicek, P., Frankish, A., Gerstein, M., Hubner, N., Ingolia, N.T., Kellis, M., Menschaert, G., Moritz, R.L., Ohler, U., Roucou, X., Saghatelian, A., Weissman, J.S. and van Heesch, S.
Nature Biotechnology 40
(7): 994–999.
July 2022
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74
(6): 1039-1046.
15 March 2022
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.
Shahan, R., Hsu, C.W., Nolan, T.M., Cole, B.J., Taylor, I.W., Greenstreet, L., Zhang, S., Afanassiev, A., Vlot, A.H.C., Schiebinger, G., Benfey, P.N. and Ohler, U.
Developmental Cell 57
(4): 543-560.
28 February 2022
Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W., Akalin, A. and Ohler, U.
Nature Machine Intelligence 4
(2): 162-168.
February 2022
Intricacies of single-cell multi-omics data integration.
Rautenstrauch, P., Vlot, A.H.C., Saran, S. and Ohler, U.
Trends in Genetics 38
(2): 128-139.
February 2022
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F., Corbo, J., Levdansky, Y., Spiegelhalter, A., Lindner, D., Magg, V., Lebedeva, S., Schweiggert, J., Schott, J., Valkov, E. and Stoecklin, G.
Nature Communications 12
(1): 7175.
9 December 2021
Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
Carley, L.N., Mojica, J.P., Wang, B., Chen, C.Y., Lin, Y.P., Prasad, K.V.S.K, Chan, E., Hsu, C.W., Keith, R., Nuñez, C.L., Olson-Manning, C.F., Rushworth, C.A., Wagner, M.R., Wang, J., Yeh, P.M., Reichelt, M., Ghattas, K., Gershenzon, J., Lee, C.R. and Mitchell-Olds, T.
Nature Ecology & Evolution 5
: 1135-1144.
August 2021
Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M. and Junker, J.P.
Nature Communications 12
: 3358.
7 June 2021
Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M.M., Lence, T., Wessels, H.H., Dassi, E., Aiello, G., Sutandy, F.X.R., Scheibe, M., Edupuganti, R.R., Busch, A., Möckel, M.M., Vermeulen, M., Butter, F., König, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A., Soldano, A. and Roignant, J.Y.
EMBO Journal 40
(4): e104975.
15 February 2021
Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L., Krupp, F., Harnett, D., Turko, P., Ambrozkiewicz, M.C., Sprink, T., Imami, K., Günnigmann, M., Zinnall, U., Vieira-Vieira, C.H., Schaub, T., Münster-Wandowski, A., Bürger, J., Borisova, E., Yamamoto, H., Rasin, M.R., Ohler, U., Beule, D., Mielke, T., Tarabykin, V., Landthaler, M., Kramer, G., Vida, I., Selbach, M. and Spahn, C.M.T.
Molecular Cell 81
(2): 304-322.
21 January 2021
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., Baßler, K., Saridaki, M., Knoll, R., Pecht, T., Kapellos, T.S., Doulou, S., Kröger, C., Herbert, M., Holsten, L., Horne, A., Gemünd, I.D., Rovina, N., Agrawal, S., Dahm, K., van Uelft, M., Drews, A., Lenkeit, L., Bruse, N., Gerretsen, J., Gierlich, J., Becker, M., Händler, K., Kraut, M., Theis, H., Mengiste, S., Domenico, E., Schulte-Schrepping, J., Seep, L., Raabe, J., Hoffmeister, C., ToVinh, M., Keitel, V., Rieke, G., Talevi, V., Skowasch, D., Aziz, N.A., Pickkers, P., van de Veerdonk, F.L., Netea, M.G., Schultze, J.L., Kox, M., Breteler, M.M.B., Nattermann, J., Koutsoukou, A., Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13
(1): 7.
13 January 2021
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P., Mishra, N., Tran, F., Bahmer, T., Best, L., Blase, J.I., Bordoni, D., Franzenburg, J., Geisen, U., Josephs-Spaulding, J., Köhler, P., Künstner, A., Rosati, E., Aschenbrenner, A.C., Bacher, P., Baran, N., Boysen, T., Brandt, B., Bruse, N., Dörr, J., Dräger, A., Elke, G., Ellinghaus, D., Fischer, J., Forster, M., Franke, A., Franzenburg, S., Frey, N., Friedrichs, A., Fuß, J., Glück, A., Hamm, J., Hinrichsen, F., Hoeppner, M.P., Imm, S., Junker, R., Kaiser, S., Kan, Y.H., Knoll, R., Lange, C., Laue, G., Lier, C., Lindner, M., Marinos, G., Markewitz, R., Nattermann, J., Noth, R., Pickkers, P., Rabe, K.F., Renz, A., Röcken, C., Rupp, J., Schaffarzyk, A., Scheffold, A., Schulte-Schrepping, J., Schunk, D., Skowasch, D., Ulas, T., Wandinger, K.P., Wittig, M., Zimmermann, J., Busch, H., Hoyer, B.F., Kaleta, C., Heyckendorf, J., Kox, M., Rybniker, J., Schreiber, S., Schultze, J.L. and Rosenstiel, P.
Immunity 53
(6): 1296-1314.
15 December 2020
Lineage-resolved enhancer and promoter usage during a time course of embryogenesis.
Reddington, J.P., Garfield, D.A., Sigalova, O.M., Karabacak Calviello, A., Marco-Ferreres, R., Girardot, C., Viales, R.R., Degner, J.F., Ohler, U. and Furlong, E.E.M.
Developmental Cell 55
(5): 648-664.
7 December 2020
Quantification of translation uncovers the functions of the alternative transcriptome.
Calviello, L., Hirsekorn, A. and Ohler, U.
Nature Structural & Molecular Biology 27
(8): 717-725.
August 2020
Deep learning for genomics using Janggu.
Kopp, W., Monti, R., Tamburrini, A., Ohler, U. and Akalin, A.
Nature Communications 11
(1): 3488.
13 July 2020
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C., Müller, M., Pak, H.S., Harnett, D., Huber, F., Grun, D., Leleu, M., Auger, A., Arnaud, M., Stevenson, B.J., Michaux, J., Bilic, I., Hirsekorn, A., Calviello, L., Simó-Riudalbas, L., Planet, E., Lubiński, J., Bryśkiewicz, M., Wiznerowicz, M., Xenarios, I., Zhang, L., Trono, D., Harari, A., Ohler, U., Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11
(1): 1293.
10 March 2020
A conserved noncoding locus regulates random monoallelic Xist expression across a topological boundary.
Galupa, R., Nora, E.P., Worsley-Hunt, R., Picard, C., Gard, C., van Bemmel, J.G., Servant, N., Zhan, Y., El Marjou, F., Johanneau, C., Diabangouaya, P., Le Saux, A., Lameiras, S., Pipoli da Fonseca, J., Loos, F., Gribnau, J., Baulande, S., Ohler, U., Giorgetti, L. and Heard, E.
Molecular Cell 77
(2): 352-367.
16 January 2020
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H., Lebedeva, S., Hirsekorn, A., Wurmus, R., Akalin, A., Mukherjee, N. and Ohler, U.
Nature Communications 10
(1): 1626.
9 April 2019
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C., Vieira-Vieira, C.H., Hick, T., Wessels, H.H., Figini, D., Moschall, R., Medenbach, J., Ohler, U., Granneman, S., Selbach, M. and Beckmann, B.M.
Nature Communications 10
(1): 990.
1 March 2019
Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
Karabacak Calviello, A., Hirsekorn, A., Wurmus, R., Yusuf, D. and Ohler, U.
Genome Biology 20
(1): 42.
21 February 2019
Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N., Wessels, H.H., Lebedeva, S., Sajek, M., Ghanbari, M., Garzia, A., Munteanu, A., Yusuf, D., Farazi, T., Hoell, J.I., Akat, K.M., Akalin, A., Tuschl, T. and Ohler, U.
Nucleic Acids Research 47
(2): 570-581.
25 January 2019
omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data.
Drewe-Boss, P., Wessels, H.H. and Ohler, U.
Genome Biology 19
: 183.
1 November 2018
Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M., Karabacak, A., Glahs, A., Kolundzic, E., Hirsekorn, A., Carda, A., Tursun, B., Zinzen, R.P., Lacadie, S.A. and Ohler, U.
Nature Communications 9
(1): 4472.
26 October 2018
Redundant regulation.
Lacadie, S.A. and Ohler, U.
Nature Ecology & Evolution 2
(3): 418-419.
March 2018
ssHMM: extracting intuitive sequence-structure motifs from high-throughput RNA-binding protein data.
Heller, D., Krestel, R., Ohler, U., Vingron, M. and Marsico, A.
Nucleic Acids Research 45
(19): 11004-11018.
2 November 2017
McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
Hafez, D., Karabacak, A., Krueger, S., Hwang, Y.C., Wang, L.S., Zinzen, R.P. and Ohler, U.
Genome Biology 18
(1): 199.
26 October 2017
Beyond read-counts: Ribo-seq data analysis to understand the functions of the transcriptome.
Calviello, L. and Ohler, U.
Trends in Genetics 33
(10): 728-744.
October 2017
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M., Imami, K., Mukherjee, N., De Bortoli, F., Zinnall, U., Hazapis, O., Trahan, C., Oeffinger, M., Heyd, F., Ohler, U., Selbach, M. and Landthaler, M.
Genome Research 27
(8): 1344-1359.
August 2017
The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
Grüning, B.A., Fallmann, J., Yusuf, D., Will, S., Erxleben, A., Eggenhofer, F., Houwaart, T., Batut, B., Videm, P., Bagnacani, A., Wolfien, M., Lott, S.C., Hoogstrate, Y., Hess, W.R., Wolkenhauer, O., Hoffmann, S., Akalin, A., Ohler, U., Stadler, P.F. and Backofen, R.
Nucleic Acids Research 45
(W1): W560-W566.
3 July 2017
RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Uyar, B., Yusuf, D., Wurmus, R., Rajewsky, N., Ohler, U. and Akalin, A.
Nucleic Acids Research 45
(10): e91.
2 June 2017
A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells.
Velasco, S., Ibrahim, M.M., Kakumanu, A., Garipler, G., Aydin, B., Al-Sayegh, M.A., Hirsekorn, A., Abdul-Rahman, F., Satija, R., Ohler, U., Mahony, S. and Mazzoni, E.O.
Cell Stem Cell 20
(2): 205-217.
2 February 2017
Integrative classification of human coding and noncoding genes through RNA metabolism profiles.
Mukherjee, N., Calviello, L., Hirsekorn, A., de Pretis, S., Pelizzola, M. and Ohler, U.
Nature Structural & Molecular Biology 24
(1): 86-96.
January 2017
The mRNA-bound proteome of the early fly embryo.
Wessels, H.H., Imami, K., Baltz, A.G., Kolinski, M., Beldovskaya, A., Selbach, M., Small, S., Ohler, U. and Landthaler, M.
Genome Research 26
(7): 1000-1009.
July 2016
Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L., Mukherjee, N., Wyler, E., Zauber, H., Hirsekorn, A., Selbach, M., Landthaler, M., Obermayer, B. and Ohler, U.
Nature Methods 13
(2): 165-170.
February 2016
Perspectives on unidirectional versus divergent transcription.
Duttke, S.H.C., Lacadie, S.A., Ibrahim, M.M., Glass, C.K., Corcoran, D.L., Benner, C., Heinz, S., Kadonaga, J.T. and Ohler, U.
Molecular Cell 60
(3): 348-349.
5 November 2015
Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A., Sozzani, R., Yardımcı, G.G., Petricka, J.J., Vernoux, T., Blilou, I., Alonso, J., Winter, C.M., Ohler, U., Scheres, B. and Benfey, P.N.
Science 350
(6259): 426-430.
23 October 2015
Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M. and Obermayer, B.
Genome Biology 16
: 179.
14 September 2015
Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.
Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H.H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., Vinuesa, C.G., Ohler, U., Standley, D.M., Landthaler, M., Fujiwara, T. and Takeuchi, O.
Cell 161
(5): 1058-1073.
21 May 2015
Human promoters are intrinsically directional.
Duttke, S.H.C., Lacadie, S.A., Ibrahim, M.M., Glass, C.K., Corcoran, D.L., Benner, C., Heinz, S., Kadonaga, J.T. and Ohler, U.
Molecular Cell 57
(4): 674-684.
19 February 2015
Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.
Zemojtel, T., Koehler, S., Mackenroth, L., Jaeger, M., Hecht, J., Krawitz, P., Graul-Neumann, L., Doelken, S., Ehmke, N., Spielmann, M., Oien, N.C., Schweiger, M.R., Krueger, U., Frommer, G., Fischer, B., Kornak, U., Floettmann, R., Ardeshirdavani, A., Moreau, Y., Lewis, S.E., Haendel, M., Smedley, D., Horn, D., Mundlos, S. and Robinson, P.N.
Science Translational Medicine 6
(252): 252ra123.
3 September 2014
Global target mRNA specification and regulation by the RNA-binding protein ZFP36.
Mukherjee, N., Jacobs, N.C., Hafner, M., Kennington, E.A., Nusbaum, J.D., Tuschl, T., Blackshear, P.J. and Ohler, U.
Genome Biology 15
(1): R12.
8 January 2014
Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits.
Megraw, M., Mukherjee, S. and Ohler, U.
Genome Biology 14
(8): R85.
23 August 2013
MicroRNA target site identification by integrating sequence and binding information.
Majoros, W.H., Lekprasert, P., Mukherjee, N., Skalsky, R.L., Corcoran, D.L., Cullen, B.R. and Ohler, U.
Nature Methods 10
(7): 630-633.
July 2013
NextGen speaks.
Lacadie, S.A.
Science 340
(6128): 29.
April 2013
Panakova, Daniela
Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D. and Junker, J.P.
Nature Genetics 54
(8): 1227-1237.
August 2022
Transient activated fibroblasts contribute to zebrafish heart regeneration.
Junker, J.P. and Panáková, D.
Nature Genetics 54
(8): 1076-1077.
August 2022
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9
(1): 2161.
4 June 2018
Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D. and Mosimann, C.
Nature Communications 9
(1): 2001.
21 May 2018
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G. and Traver, D.
EMBO Journal 33
(20): 2363-2373.
16 October 2014
Paul, Friedemann (ECRC)
Autoantigen-specific CD4(+) T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.S., Dargvainiene, J., Martini, G.R., Stürner, K.H., Schröder, I., Markewitz, R., Hartl, J., Hastermann, M., Duchow, A., Schindler, P., Becker, M., Bautista, C., Gottfreund, J., Walter, J., Polansky, J.K., Yang, M., Naghavian, R., Wendorff, M., Schuster, E.M., Dahl, A., Petzold, A., Reinhardt, S., Franke, A., Wieczorek, M., Henschel, L., Berger, D., Heine, G., Holtsche, M., Häußler, V., Peters, C., Schmidt, E., Fillatreau, S., Busch, D.H., Wandinger, K.P., Schober, K., Martin, R., Paul, F., Leypoldt, F. and Scheffold, A.
Immunity 57
(10): 2416-2432.e8.
8 October 2024
The influence of MOGAD on diagnosis of multiple sclerosis using MRI.
Geraldes, R., Arrambide, G., Banwell, B., Rovira, À., Cortese, R., Lassmann, H., Messina, S., Rocca, M.A., Waters, P., Chard, D., Gasperini, C., Hacohen, Y., Mariano, R., Paul, F., DeLuca, G.C., Enzinger, C., Kappos, L., Leite, M.I., Sastre-Garriga, J., Yousry, T., Ciccarelli, O., Filippi, M., Barkhof, F. and Palace, J.
Nature Reviews Neurology 20
(10): 620-635.
October 2024
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.
Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J.I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J.P., Zimmermann, H.G., Oertel, F.C., Ringelstein, M., Brandt, A.U., Paul, F., Aktas, O., Hartung, H.P., Wiendl, H., Meuth, S.G. and Albrecht, P.
Nature Communications 15
(1): 5243.
19 June 2024
Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories.
Gross, C.C., Schulte-Mecklenbeck, A., Steinberg, O.V., Wirth, T., Lauks, S., Bittner, S., Schindler, P., Baranzini, S.E., Groppa, S., Bellmann-Strobl, J., Bünger, N., Chien, C., Dawin, E., Eveslage, M., Fleischer, V., Gonzalez-Escamilla, G., Gisevius, B., Haas, J., Kerschensteiner, M., Kirstein, L., Korsukewitz, C., Lohmann, L., Lünemann, J.D., Luessi, F., Meyer Zu Hörste, G., Motte, J., Ruck, T., Ruprecht, K., Schwab, N., Steffen, F., Meuth, S.G., Paul, F., Wildemann, B., Kümpfel, T., Gold, R., Hahn, T., Zipp, F., Klotz, L. and Wiendl, H.
Science Translational Medicine 16
(740): eade8560.
March 2024
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133
(13): e164637.
3 July 2023
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.
Arends, C.M., Liman, T.G., Strzelecka, P.M., Kufner, A., Löwe, P., Huo, S., Stein, C.M., Piper, S.K., Tilgner, M., Sperber, P.S., Dimitriou, S., Heuschmann, P., Hablesreiter, R., Harms, C., Bullinger, L., Weber, J.E., Endres, M. and Damm, F.
Blood 141
(7): 787-799.
16 February 2023
First in vivo fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod.
Starke, L., Millward, J.M., Prinz, C., Sherazi, F., Waiczies, H., Lippert, C., Nazaré, M., Paul, F., Niendorf, T. and Waiczies, S.
Theranostics 13
(4): 1217-1234.
5 February 2023
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93
(9): 960-971.
September 2022
In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Prinz, C., Starke, L., Millward, J.M., Fillmer, A., Delgado, P.R., Waiczies, H., Pohlmann, A., Rothe, M., Nazaré, M., Paul, F., Niendorf, T. and Waiczies, S.
Theranostics 11
(6): 2490-2504.
1 January 2021
Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Dusek, P., Mekle, R., Skowronska, M., Acosta-Cabronero, J., Huelnhagen, T., Robinson, S.D., Schubert, F., Deschauer, M., Els, A., Ittermann, B., Schottmann, G., Madai, V.I., Paul, F., Klopstock, T., Kmiec, T., Niendorf, T., Wuerfel, J. and Schneider, S.A.
Movement Disorders 35
(1): 142-150.
January 2020
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10
(1): 217.
15 January 2019
Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye, J., Wenke, N.K., Chayka, M., Leubner, J., Murugan, R., Maier, N., Jurek, B., Ly, L.T., Brandl, D., Rost, B.R., Stumpf, A., Schulz, P., Radbruch, H., Hauser, A.E., Pache, F., Meisel, A., Harms, L., Paul, F., Dirnagl, U., Garner, C., Schmitz, D., Wardemann, H. and Prüss, H.
Brain 139
(10): 2641-2652.
1 October 2016
Chronic cerebrospinal venous insufficiency in multiple sclerosis: the final curtain.
Paul, F. and Wattjes, M.P.
Lancet 383
(9912): 106-108.
11 January 2014
Peters, Oliver (ECRC)
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann, S.M., Krueger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., Habbel, P., Kaelin, R., Franzoni, E., Rybak, A., Nguyen, D., Veh, R., Ninnemann, O., Peters, O., Nitsch, R., Heppner, F.L., Golenbock, D., Schott, E., Ploegh, H.L., Wulczyn, F.G. and Lehnardt, S.
Nature Neuroscience 15
(6): 827-835.
June 2012
Pezzutto, Antonio
High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.
Çınar, Ö., Brzezicha, B., Grunert, C., Kloetzel, P.M., Beier, C., Peuker, C.A., Keller, U., Pezzutto, A. and Busse, A.
Journal for ImmunoTherapy of Cancer 9
(7): e002410.
30 July 2021
Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
Wulf, G.G., Altmann, B., Ziepert, M., D'Amore, F., Held, G., Greil, R., Tournilhac, O., Relander, T., Viardot, A., Wilhelm, M., Wilhelm, C., Pezzutto, A., Zijlstra, J.M., Van Den Neste, E., Lugtenburg, P.J., Doorduijn, J.K., van Gelder, M., van Imhoff, G.W., Zettl, F., Braulke, F., Nickelsen, M., Glass, B., Rosenwald, A., Gaulard, P., Loeffler, M., Pfreundschuh, M., Schmitz, N. and Trümper, L.
Leukemia 35
(1): 143-155.
January 2021
High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Hehlmann, R., Voskanyan, A., Lauseker, M., Pfirrmann, M., Kalmanti, L., Rinaldetti, S., Kohlbrenner, K., Haferlach, C., Schlegelberger, B., Fabarius, A., Seifarth, W., Spieß, B., Wuchter, P., Krause, S., Kolb, H.J., Neubauer, A., Hossfeld, D.K., Nerl, C., Gratwohl, A., Baerlocher, G.M., Burchert, A., Brümmendorf, T.H., Hasford, J., Hochhaus, A., Saußele, S. and Baccarani, M.
Leukemia 34
(8): 2074-2086.
August 2020
Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part phase Ib/II study.
Rambaldi, A., Iurlo, A., Vannucchi, A.M., Noble, R., von Bubnoff, N., Guarini, A., Martino, B., Pezzutto, A., Carli, G., De Muro, M., Luciani, S., McMullin, M.F., Cambier, N., Marolleau, J.P., Mesa, R.A., Tibes, R., Pancrazzi, A., Gesullo, F., Bettica, P., Manzoni, S. and Di Tollo, S.
Leukemia 34
(8): 2234-2237.
August 2020
Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
Horwitz, S., O'Connor, O.A., Pro, B., Illidge, T., Fanale, M., Advani, R., Bartlett, N.L., Christensen, J.H., Morschhauser, F., Domingo-Domenech, E., Rossi, G., Kim, W.S., Feldman, T., Lennard, A., Belada, D., Illés, A., Tobinai, K., Tsukasaki, K., Yeh, S.P., Shustov, A., Hüttmann, A., Savage, K.J., Yuen, S., Iyer, S., Zinzani, P.L., Hua, Z., Little, M., Rao, S., Woolery, J., Manley, T. and Trümper, L.
Lancet 393
(10168): 229-240.
19 January 2019
Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
Hehlmann, R., Lauseker, M., Saußele, S., Pfirrmann, M., Krause, S., Kolb, H.J., Neubauer, A., Hossfeld, D.K., Nerl, C., Gratwohl, A., Baerlocher, G.M., Heim, D., Brümmendorf, T.H., Fabarius, A., Haferlach, C., Schlegelberger, B., Müller, M.C., Jeromin, S., Proetel, U., Kohlbrenner, K., Voskanyan, A., Rinaldetti, S., Seifarth, W., Spieß, B., Balleisen, L., Goebeler, M.C., Hänel, M., Ho, A., Dengler, J., Falge, C., Kanz, L., Kremers, S., Burchert, A., Kneba, M., Stegelmann, F., Köhne, C.A., Lindemann, H.W., Waller, C.F., Pfreundschuh, M., Spiekermann, K., Berdel, W.E., Müller, L., Edinger, M., Mayer, J., Beelen, D.W., Bentz, M., Link, H., Hertenstein, B., Fuchs, R., Wernli, M., Schlegel, F., Schlag, R., de Wit, M., Trümper, L., Hebart, H., Hahn, M., Thomalla, J., Scheid, C., Schafhausen, P., Verbeek, W., Eckart, M.J., Gassmann, W., Pezzutto, A., Schenk, M., Brossart, P., Geer, T., Bildat, S., Schäfer, E., Hochhaus, A. and Hasford, J.
Leukemia 31
(11): 2398-2406.
November 2017
Phase II trial of temsirolimus for relapsed/refractory primary CNS lymphoma.
Korfel, A., Schlegel, U., Herrlinger, U., Dreyling, M., Schmidt, C., von Baumgarten, L., Pezzutto, A., Grobosch, T., Kebir, S., Thiel, E., Martus, P. and Kiewe, P.
Journal of Clinical Oncology 34
(15): 1757-1763.
20 May 2016
Radioimmunotherapy in relapsed/refractory mantle cell lymphoma patients: final results of a European MCL network phase II trial.
Ferrero, S., Pastore, A., Scholz, C.W., Forstpointner, R., Pezzutto, A., Bergmann, L., Truemper, L., Finke, J., Keller, U., Ghione, P., Passera, R., Hiddemann, W., Weigert, O., Unterhalt, M. and Dreyling, M.
Leukemia 30
(4): 984-987.
April 2016
Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML-Study IV.
Saussele, S., Krauss, M.P., Hehlmann, R., Lauseker, M., Proetel, U., Kalmanti, L., Hanfstein, B., Fabarius, A., Kraemer, D., Berdel, W.E., Bentz, M., Staib, P., de Wit, M., Wernli, M., Zettl, F., Hebart, H.F., Hahn, M., Heymanns, J., Schmidt-Wolf, I., Schmitz, N., Eckart, M.J., Gassmann, W., Bartholomaeus, A., Pezzutto, A., Oppliger Leibundgut, E., Heim, D., Krause, S.W., Burchert, A., Hofmann, W.K., Hasford, J., Hochhaus, A., Pfirrmann, M. and Müller, M.C.
Blood 126
(1): 42-49.
2 July 2015
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.
Mensen, A., Jöhrens, K., Anagnostopoulos, I., Demski, S., Oey, M., Stroux, A., Hemmati, P., Westermann, J., Blau, O., Wittenbecher, F., Movassaghi, K., Szyska, M., Thomas, S., Dörken, B., Scheibenbogen, C., Arnold, R. and Na, I.K.
Blood 124
(6): 963-972.
7 August 2014
(90)Yttrium-ibritumomab-tiuxetan as first-line treatment for follicular lymphoma: 30 months of follow-up data from an international multicenter phase II clinical trial.
Scholz, C.W., Pinto, A., Linkesch, W., Lindén, O., Viardot, A., Keller, U., Hess, G., Lastoria, S., Lerch, K., Frigeri, F., Arcamone, M., Stroux, A., Frericks, B., Pott, C. and Pezzutto, A.
Journal of Clinical Oncology 31
(3): 308-313.
20 January 2013
Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R.A., Daniel, P.T., Bommert, K., Vassilev, L.T. and Bargou, R.C.
Blood 106
: 3609-3617.
4 August 2005
Piazza, Ilaria
Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Malinovska, L., Cappelletti, V., Kohler, D., Piazza, I., Tsai, T.H., Pepelnjak, M., Stalder, P., Dörig, C., Sesterhenn, F., Elsässer, F., Kralickova, L., Beaton, N., Reiter, L., de Souza, N., Vitek, O. and Picotti, P.
Nature Protocols 18
: 659-682.
16 March 2023
Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li, B., Zeis, P., Zhang, Y., Alekseenko, A., Fürst, E., Sanchez, Y.P., Lin, G., Tekkedil, M.M., Piazza, I., Steinmetz, L.M. and Pelechano, V.
Nature Communications 14
(1): 910.
17 February 2023
The rise of proteome-wide biophysics.
Mateus, A., Savitski, M.M. and Piazza, I.
Molecular Systems Biology 17
(7): e10442.
July 2021
A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I., Beaton, N., Bruderer, R., Knobloch, T., Barbisan, C., Chandat, L., Sudau, A., Siepe, I., Rinner, O., de Souza, N., Picotti, P. and Reiter, L.
Nature Communications 11
(1): 4200.
21 August 2020
Pischon, Tobias
Likelihood of post-COVID condition in people with hybrid immunity; data from the German National Cohort (NAKO).
Mikolajczyk, R., Diexer, S., Klee, B., Pfrommer, L., Purschke, O., Fricke, J., Ahnert, P., Gabrysch, S., Gottschick, C., Bohn, B., Brenner, H., Buck, C., Castell, S., Gastell, S., Greiser, K.H., Harth, V., Heise, J.K., Holleczek, B., Kaaks, R., Keil, T., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, Cl., Michels, K.B., Moreno Velásquez, I., Obi, N., Panreck, L., Peters, A., Pischon, T., Schikowski, T., Schmidt, B., Standl, M., Stang, A., Völzke, H., Weber, A., Zeeb, H. and Karch, A.
Journal of Infection 89
(2): 106206.
August 2024
Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.
Fislage, M., Winzeck, S., Woodrow, R., Lammers-Lietz, F., Stamatakis, E.A., Correia, M.M., Preller, J., Feinkohl, I., Hendrikse, J., Pischon, T., Spies, C.D., Slooter, A.J.C., Winterer, G., Menon, D.K. and Zacharias, N.
Alzheimer's and Dementia 20
(4): 2861-2872.
April 2024
Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
Haueise, T., Schick, F., Stefan, N., Schlett, C.L., Weiss, J.B., Nattenmüller, J., Göbel-Guéniot, K., Norajitra, T., Nonnenmacher, T., Kauczor, H.U., Maier-Hein, K.H., Niendorf, T., Pischon, T., Jöckel, K.H., Umutlu, L., Peters, A., Rospleszcz, S., Kröncke, T., Hosten, N., Völzke, H., Krist, L., Willich, S.N., Bamberg, F. and Machann, J.
Science Advances 9
(19): eadd0433.
12 May 2023
Framework and baseline examination of the German National Cohort (NAKO).
Peters, A., Peters, A., Greiser, K.H., Göttlicher, S., Ahrens, W., Albrecht, M., Bamberg, F., Bärnighausen, T., Becher, H., Berger, K., Beule, A., Boeing, H., Bohn, B., Bohnert, K., Braun, B., Brenner, H., Bülow, R., Castell, S., Damms-Machado, A., Dörr, M., Ebert, N., Ecker, M., Emmel, C., Fischer, B., Franzke, C.W., Gastell, S., Giani, G., Günther, M., Günther, K., Günther, K.P., Haerting, J., Haug, U., Heid, I.M., Heier, M., Heinemeyer, D., Hendel, T., Herbolsheimer, F., Hirsch, J., Hoffmann, W., Holleczek, B., Hölling, H., Hörlein, A., Jöckel, K.H., Kaaks, R., Karch, A., Karrasch, S., Kartschmit, N., Kauczor, H.U., Keil, T., Kemmling, Y., Klee, B., Klüppelholz, B., Kluttig, A., Kofink, L., Köttgen, A., Kraft, D., Krause, G., Kretz, L., Krist, L., Kühnisch, J., Kuß, O., Legath, N., Lehnich, A.T., Leitzmann, M., Lieb, W., Linseisen, J., Loeffler, M., Macdonald, A., Maier-Hein, K.H., Mangold, N., Meinke-Franze, C., Meisinger, C., Melzer, J., Mergarten, B., Michels, K.B., Mikolajczyk, R., Moebus, S., Mueller, U., Nauck, M., Niendorf, T., Nikolaou, K., Obi, N., Ostrzinski, S., Panreck, L., Pigeot, I., Pischon, T., Pschibul-Thamm, I., Rathmann, W., Reineke, A., Roloff, S., Rujescu, D., Rupf, S., Sander, O., Schikowski, T., Schipf, S., Schirmacher, P., Schlett, C.L., Schmidt, B., Schmidt, G., Schmidt, M., Schöne, G., Schulz, H., Schulze, M.B., Schweig, A., Sedlmeier, A.M., Selder, S., Six-Merker, J., Sowade, R., Stang, A., Stegle, O., Steindorf, K., Stübs, G., Swart, E., Teismann, H., Thiele, I., Thierry, S., Ueffing, M., Völzke, H., Waniek, S., Weber, A., Werner, N., Wichmann, H.E., Willich, S.N., Wirkner, K., Wolf, K., Wolff, R., Zeeb, H., Zinkhan, M. and Zschocke, J.
European Journal of Epidemiology 37
(10): 1107-1124.
October 2022
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019.
Tran, K.B., Lang, J.J., Compton, K., Xu, R., Acheson, A.R., Henrikson, H.J., Kocarnik, J.M., Penberthy, L., Aali, A., Abbas, Q., Abbasi, B., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abbastabar, H., Abdelmasseh, M., Abd-Elsalam, S., Abdelwahab, A.A., Abdoli, G., Abdulkadir, H.A., Abedi, A., Abegaz, K.H., Abidi, H., Aboagye, R.G., Abolhassani, H., Absalan, A., Abtew, Yo.D., Abubaker Ali, H., Abu-Gharbieh, E., Achappa, B., Acuna, J.M., Addison, D., Addo, I.Y., Adegboye, O.A., Adesina, M.A., Adnan, M., Adnani, Q.E.S., Advani, S.M., Afrin, S., Afzal, M.S., Aggarwal, M., Ahinkorah, B.O., Ahmad, A.R., Ahmad, R., Ahmad, S., Ahmad, S., Ahmadi, S., Ahmed, H., Ahmed, L.A., Ahmed, M.B., Ahmed Rashid, T., Aiman, W., Ajami, M., Akalu, G.T., Akbarzadeh-Khiavi, M., Aklilu, A., Akonde, M., Akunna, C.J., Al Hamad, H., Alahdab, F., Alanezi, F.M., Alanzi, T.M., Alessy, S.A., Algammal, A.M., Al-Hanawi, M.K., Alhassan, R.K., Ali, B.A., Ali, L., Ali, S.S., Alimohamadi, Y., Alipour, V., Aljunid, S.M., Alkhayyat, M., Al-Maweri, S.A.A., Almustanyir, S., Alonso, N., Alqalyoobi, S., Al-Raddadi, R.M., Al-Rifai, R.H.H., Al-Sabah, S.K., Al-Tammemi, A.B., Altawalah, H., Alvis-Guzman, N., Amare, F., Ameyaw, E.K., Aminian Dehkordi, J.J., Amirzade-Iranaq, M.H., Amu, H., Amusa, G.A., Ancuceanu, R., Anderson, J.A., Animut, Y.A., Anoushiravani, A., Anoushirvani, A.A., Ansari-Moghaddam, A., Ansha, M.G., Antony, B., Antwi, M.H., Anwar, S.L., Anwer, R., Anyasodor, A.E., Arabloo, J., Arab-Zozani, M., Aremu, O., Argaw, A.M., Ariffin, H., Aripov, T., Arshad, M., Artaman, A., Arulappan, J., Aruleba, R.T., Aryannejad, A., Asaad, M., Asemahagn, M.A., Asemi, Z., Asghari-Jafarabadi, M., Ashraf, T., Assadi, R., Athar, M., Athari, S.S., Atout, M.M.W., Attia, S., Aujayeb, A., Ausloos, M., Avila-Burgos, L., Awedew, A.F., Awoke, M.A., Awoke, T., Ayala Quintanilla, B.P., Ayana, T.M., Ayen, S.S., Azadi, D., Azadnajafabad, S., Azami-Aghdash, S., Azanaw, M.M., Azangou-Khyavy, M., Azari Jafari, A., Azizi, H., Azzam, A.Y.Y., Babajani, A., Badar, M., Badiye, A.D., Baghcheghi, N., Bagheri, N., Bagherieh, S., Bahadory, S., Baig, A.A., Baker, J.L., Bakhtiari, A., Bakshi, R.K., Banach, M., Banerjee, I., Bardhan, M., Barone-Adesi, F., Barra, F., Barrow, A., Bashir, N.Z., Bashiri, A., Basu, S., Batiha, A.M.M., Begum, A., Bekele, A.B., Belay, A.S., Belete, M.A., Belgaumi, U.I., Bell, A.W., Belo, L., Benzian, H., Berhie, A.Y., Bermudez, A.N.C., Bernabe, E., Bhagavathula, A.S., Bhala, N., Bhandari, B.B., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhojaraja, V.S., Bhuyan, S.S., Bibi, S., Bilchut, A.H., Bintoro, B.S., Biondi, A., Birega, M.G.B., Birhan, H.E., Bjørge, T., Blyuss, O., Bodicha, B.B.A., Bolla, S.R., Boloor, A., Bosetti, C., Braithwaite, D., Brauer, M., Brenner, H., Briko, A.N., Briko, N.I., Buchanan, C.M., Bulamu, N.B., Bustamante-Teixeira, M.T., Butt, M.H., Butt, N.S., Butt, Z.A., Caetano dos Santos, F.L., Cámera, L.A., Cao, C., Cao, Y., Carreras, G., Carvalho, M., Cembranel, F., Cerin, E., Chakraborty, P.A., Charalampous, P., Chattu, V.K., Chimed-Ochir, O., Chirinos-Caceres, J.L., Cho, D.Y., Cho, W.C.S., Christopher, D.J., Chu, D.T., Chukwu, I.S., Cohen, A.J., Conde, J., Cortés, S., Costa, V.M., Cruz-Martins, N., Culbreth, G.T., Dadras, O., Dagnaw, F.T., Dahlawi, S.M.A, Dai, X., Dandona, L., Dandona, R., Daneshpajouhnejad, P., Danielewicz, A., Dao, A.T.M., Darvishi Cheshmeh Soltani, R., Darwesh, A.M., Das, S., Davitoiu, D.V., Davtalab Esmaeili, E., De la Hoz, F.P., Debela, S.A., Dehghan, A., Demisse, B., Demisse, F.W., Denova-Gutiérrez, E., Derakhshani, A., Derbew Molla, M., Dereje, D., Deribe, K.S., Desai, R., Desalegn, M.D., Dessalegn, F.N., Dessalegni, S.A.A., Dessie, G., Desta, A.A., Dewan, S.M.R., Dharmaratne, S.D., Dhimal, M., Dianatinasab, M., Diao, N., Diaz, D., Digesa, L.E., Dixit, S.G., Doaei, S., Doan, L.P., Doku, P.N., Dongarwar, D., dos Santos, W.M., Driscoll, T.R., Dsouza, H.L., Durojaiye, O.C., Edalati, S., Eghbalian, F., Ehsani-Chimeh, E., Eini, E., Ekholuenetale, M., Ekundayo, T.C., Ekwueme, D.U., El Tantawi, M., Elbahnasawy, M.A., Elbarazi, I., Elghazaly, H., Elhadi, M., El-Huneidi, W., Emamian, M.H., Engelbert Bain, L., Enyew, D.B., Erkhembayar, R., Eshetu, T., Eshrati, B., Eskandarieh, S., Espinosa-Montero, J., Etaee, F., Etemadimanesh, A., Eyayu, T., Ezeonwumelu, I.J., Ezzikouri, S., Fagbamigbe, A.F., Fahimi, S., Fakhradiyev, I.R., Faraon, E.J.A., Fares, J., Farmany, A., Farooque, U., Farrokhpour, H., Fasanmi, A.O., Fatehizadeh, A., Fatima, W., Fattahi, H., Fekadu, G., Feleke, B.E., Ferrari, A.A., Ferrero, S., Ferro Desideri, L., Filip, I., Fischer, F., Foroumadi, R., Foroutan, M., Fukumoto, T., Gaal, P.A., Gad, M.M., Gadanya, M.A., Gaipov, A., Galehdar, N., Gallus, S., Garg, T., Gaspar Fonseca, M., Gebremariam, Y.H., Gebremeskel, T.G., Gebremichael, M.A., Geda, Y.F., Gela, Y.Y., Gemeda, B.N.B., Getachew, M., Getachew, M.E., Ghaffari, K., Ghafourifard, M., Ghamari, S.H., Ghasemi Nour, M., Ghassemi, F., Ghimire, A., Ghith, N., Gholamalizadeh, M., Gholizadeh Navashenaq, J., Ghozy, S., Gilani, S.A., Gill, P.S., Ginindza, T.G., Gizaw, A.T.T., Glasbey, J.C., Godos, J., Goel, A., Golechha, M., Goleij, P., Golinelli, D., Golitaleb, M., Gorini, G., Goulart, B.N.G., Grosso, G., Guadie, H.A., Gubari, M.I.M., Gudayu, T.W., Guerra, M.R., Gunawardane, D.A., Gupta, B., Gupta, S., Gupta, V.B., Gupta, V.K., Gurara, M.K., Guta, A., Habibzadeh, P., Haddadi Avval, A., Hafezi-Nejad, N., Hajj Ali, A., Haj-Mirzaian, A., Halboub, E.S., Halimi, A., Halwani, R., Hamadeh, R.R., Hameed, S., Hamidi, S., Hanif, A., Hariri, S., Harlianto, N.I., Haro, J.M., Hartono, R.K., Hasaballah, A.I., Hasan, S.M.M., Hasani, H., Hashemi, S.M., Hassan, A.M., Hassanipour, S., Hayat, K., Heidari, G., Heidari, M., Heidarymeybodi, Z., Herrera-Serna, B.Y., Herteliu, C., Hezam, K., Hiraike, Y., Hlongwa, M.M., Holla, R., Holm, M., Horita, N., Hoseini, M., Hossain, M.M., Hossain, M.B.H., Hosseini, M.S., Hosseinzadeh, A., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Huang, J., Hugo, F.N., Humayun, A., Hussain, S., Hussein, N.R., Hwang, B.F., Ibitoye, S.E., Iftikhar, P.M., Ikuta, K.S., Ilesanmi, O.St., Ilic, I.M., Ilic, M.D., Immurana, M., Innos, K., Iranpour, P., Irham, L.M., Islam, M.S., Islam, R.M., Islami, F., Ismail, N.E., Isola, G., Iwagami, M., J, L.M., Jaiswal, A., Jakovljevic, M., Jalili, M., Jalilian, S., Jamshidi, E., Jang, S.I., Jani, C.T., Javaheri, T., Jayarajah, U.U., Jayaram, S., Jazayeri, S.B., Jebai, R., Jemal, B., Jeong, W., Jha, R.P., Jindal, H.A., John-Akinola, Y.O., Jonas, J.B., Joo, T., Joseph, N., Joukar, F., Jozwiak, J.J., Jürisson, M., Kabir, A., Kacimi, S.E.O., Kadashetti, V., Kahe, F., Kakodkar, P.V., Kalankesh, L.R., Kalankesh, L.R., Kalhor, R., Kamal, V.K., Kamangar, F., Kamath, A., Kanchan, T., Kandaswamy, E., Kandel, H., Kang, H.J., Kanno, G.G., Kapoor, N., Kar, S.S., Karanth, S.D., Karaye, I.M., Karch, A., Karimi, A., Kassa, B.G., Katoto, P.D.M.C., Kauppila, J.H., Kaur, H., Kebede, A.G., Keikavoosi-Arani, L., Kejela, G.G., Kemp Bohan, P.M., Keramati, M., Keykhaei, M., Khajuria, H., Khan, A., Khan, A.A.K., Khan, E.A., Khan, G., Khan, M.N., Khan, M.A.B., Khanali, J., Khatab, K., Khatatbeh, M.M., Khatib, M.N., Khayamzadeh, M., Khayat Kashani, H.R., Khazeei Tabari, M.A., Khezeli, M., Khodadost, M., Kim, M.S., Kim, Y.J., Kisa, A., Kisa, S., Klugar, M., Klugarová, J., Kolahi, A.A., Kolkhir, P., Kompani, F., Koul, P.A., Koulmane Laxminarayana, S.L., Koyanagi, A., Krishan, K., Krishnamoorthy, Y., Kucuk Bicer, B., Kugbey, N., Kulimbet, M., Kumar, A., Kumar, G.A., Kumar, N., Kurmi, O.P., Kuttikkattu, A., La Vecchia, C., Lahiri, A., Lal, D.K., Lám, J., Lan, Q., Landires, I., Larijani, B., Lasrado, S., Lau, J., Lauriola, P., Ledda, C., Lee, S.W., Lee, S.W.H., Lee, W.C., Lee, Y.Y., Lee, Y.H., Legesse, S.M., Leigh, J., Leong, E., Li, M.C., Lim, S.S., Liu, G., Liu, J., Lo, C.H., Lohiya, A., Lopukhov, P.D., Lorenzovici, L., Lotfi, M., Loureiro, J.A., Lunevicius, R., Madadizadeh, F., Mafi, A.R., Magdeldin, S., Mahjoub, S., Mahmoodpoor, A., Mahmoudi, M., Mahmoudimanesh, M., Mahumud, R.A., Majeed, A., Majidpoor, J., Makki, A., Makris, K.C., Malakan Rad, E., Malekpour, M.R., Malekzadeh, R., Malik, A.A., Mallhi, T.H., Mallya, S.D., Mamun, M.A., Manda, A.L., Mansour-Ghanaei, F., Mansouri, B., Mansournia, M.A., Mantovani, L.G., Martini, S., Martorell, M., Masoudi, S., Masoumi, S.Z., Matei, C.N., Mathews, E., Mathur, M.R., Mathur, V., McKee, M., Meena, J.K., Mehmood, K., Mehrabi Nasab, E., Mehrotra, R., Melese, A., Mendoza, W., Menezes, R.G., Mengesha, S.D., Mensah, L.G., Mentis, A.F.A., Mera-Mamián, A.Y.M., Meretoja, T.J., Merid, M.W., Mersha, A.G., Meselu, B.T., Meshkat, M., Mestrovic, T., Miao Jonasson, J., Miazgowski, T., Michalek, I.M., Mijena, G.F.W., Miller, T.R., Mir, S.A., Mirinezhad, S.K., Mirmoeeni, S., Mirza-Aghazadeh-Attari, M., Mirzaei, H., Mirzaei, H.R., Misganaw, A.S., Misra, S., Mohammad, K.A., Mohammadi, E., Mohammadi, M., Mohammadian-Hafshejani, A., Mohammadpourhodki, R., Mohammed, A., Mohammed, S., Mohan, S., Mohseni, M., Moka, N., Mokdad, A.H., Molassiotis, A., Molokhia, M., Momenzadeh, K., Momtazmanesh, S., Monasta, L., Mons, U., Montasir, A.A., Montazeri, F., Montero, A., Moosavi, M.A., Moradi, A., Moradi, Y., Moradi Sarabi, M., Moraga, P., Morawska, L., Morrison, S.D., Morze, J., Mosapour, A., Mostafavi, E., Mousavi, S.M., Mousavi Isfahani, H., Mousavi Khaneghah, A., Mpundu-Kaambwa, C., Mubarik, S., Mulita, F., Munblit, D., Munro, S.B., Murillo-Zamora, E., Musa, J., Nabhan, A.F., Nagarajan, A.J., Nagaraju, S.P., Nagel, G., Naghipour, M., Naimzada, M.D., Nair, T.S., Naqvi, A.A., Narasimha Swamy, S., Narayana, A.I., Nassereldine, H., Natto, Z.S., Nayak, B.P., Ndejjo, R., Nduaguba, S.O., Negash, W.W., Nejadghaderi, S.A., Nejati, K., Neupane Kandel, S., Nguyen, H.V.N., Niazi, R.K., Noor, N.M., Noori, M., Noroozi, N., Nouraei, H., Nowroozi, A., Nuñez-Samudio, V., Nzoputam, C.I., Nzoputam, O.J., Oancea, B., Odukoya, O.O., Oghenetega, O.B., Ogunsakin, R.E., Oguntade, A.S., Oh, I.H., Okati-Aliabad, H., Okekunle, A.P., Olagunju, A.T., Olagunju, T.O., Olakunde, B.O., Olufadewa, I.L., Omer, E., Omonisi, A.E.E., Ong, S., Onwujekwe, O.E., Orru, H., Otstavnov, S.S., Oulhaj, A., Oumer, B., Owopetu, O.F., Oyinloye, B.E., P A, M., Padron-Monedero, A., Padubidri, J., Pakbin, B., Pakshir, K., Pakzad, R., Palicz, T., Pana, A., Pandey, A., Pandey, A., Pant, S., Pardhan, S., Park, E.C., Park, E.K., Park, S., Patel, J., Pati, S., Paudel, R., Paudel, U., Paun, M., Pazoki Toroudi, H., Peng, M., Pereira, J., Pereira, R.B., Perna, S., Perumalsamy, N., Pestell, R.G., Pezzani, R., Piccinelli, C., Pillay, J.D., Piracha, Z.Z., Pischon, T., Postma, M.J., Pourabhari Langroudi, A., Pourshams, A., Pourtaheri, N., Prashant, A., Qadir, M.M.F., Quazi Syed, Z., Rabiee, M., Rabiee, N., Radfar, A., Radhakrishnan, R.A., Radhakrishnan, V., Raeisi, M., Rafiee, A., Rafiei, A., Raheem, N., Rahim, F., Rahman, M.O., Rahman, M., Rahman, M.A., Rahmani, A.M., Rahmani, S., Rahmanian, V., Rajai, N., Rajesh, A., Ram, P., Ramezanzadeh, K., Rana, J., Ranabhat, K., Ranasinghe, P., Rao, C.R., Rao, S.J., Rashedi, S., Rashidi, A., Rashidi, M., Rashidi, M.M., Ratan, Z.A., Rawaf, D.L., Rawaf, S., Rawal, L., Rawassizadeh, R., Razeghinia, M.S., Rehman, A.U., Rehman, I.U., Reitsma, M.B, Renzaho, A.M.N., Rezaei, M., Rezaei, N., Rezaei, N., Rezaei, N., Rezaei, S., Rezaeian, M., Rezapour, A., Riad, A., Rikhtegar, R., Rios-Blancas, M., Roberts, T.J., Rohloff, P., Romero-Rodríguez, E., Roshandel, G., Rwegerera, G.M., S, M., Saber-Ayad, M.M., Saberzadeh-Ardestani, B., Sabour, S., Saddik, B., Sadeghi, E., Saeb, M.R., Saeed, U., Safaei, M., Safary, A., Sahebazzamani, M., Sahebkar, A., Sahoo, H., Sajid, M.R., Salari, H., Salehi, S., Salem, M.R., Salimzadeh, H., Samodra, Y.L., Samy, A.M., Sanabria, J., Sankararaman, S., Sanmarchi, F., Santric-Milicevic, M.M., Saqib, M.A.N., Sarveazad, A., Sarvi, F., Sathian, B., Satpathy, M., Sayegh, N., Schneider, I.J.C., Schwarzinger, M., Šekerija, M., Senthilkumaran, S., Sepanlou, S.G., Seylani, A., Seyoum, K., Sha, F., Shafaat, O., Shah, P.A., Shahabi, S., Shahid, I., Shahrbaf, M.A., Shahsavari, H.R., Shaikh, M.A., Shaka, M.F., Shaker, E., Shannawaz, M., Sharew, M.M.S., Sharifi, A., Sharifi-Rad, J., Sharma, P., Shashamo, B.B., Sheikh, A., Sheikh, M., Sheikhbahaei, S., Sheikhi, R.A., Sheikhy, A., Shepherd, P.R., Shetty, A., Shetty, J.K., Shetty, R.S., Shibuya, K., Shirkoohi, R., Shirzad-Aski, H., Shivakumar, K.M., Shivalli, S., Shivarov, V., Shobeiri, P., Shokri Varniab, Z., Shorofi, S.A., Shrestha, S., Sibhat, M.M., Siddappa Malleshappa, S.K., Sidemo, N.B., Silva, D.A.S., Silva, L.M.L.R., Silva Julian, G., Silvestris, N., Simegn, W., Singh, A.D., Singh, A., Singh, G., Singh, H., Singh, J.A., Singh, J.K., Singh, P., Singh, S., Sinha, D.N., Sinke, A.H., Siraj, M.S., Sitas, F., Siwal, S.S., Skryabin, V.Y., Skryabina, A. A., Socea, B., Soeberg, M.J., Sofi-Mahmudi, A., Solomon, Y., Soltani-Zangbar, M.S., Song, S., Song, Y., Sorensen, R.J.D., Soshnikov, S., Sotoudeh, H., Sowe, A., Sufiyan, M.B., Suk, R., Suleman, M., Suliankatchi Abdulkader, R., Sultana, S., Sur, D., Szócska, M., Tabaeian, S.P., Tabarés-Seisdedos, R., Tabatabaei, S.M., Tabuchi, T., Tadbiri, H., Taheri, E., Taheri, M., Taheri Soodejani, M., Takahashi, K., Talaat, I.M., Tampa, M., Tan, K.K., Tat, N.Y., Tat, V.Y., Tavakoli, A., Tavakoli, A., Tehrani-Banihashemi, A., Tekalegn, Y., Tesfay, F.H., Thapar, R., Thavamani, A., Thoguluva Chandrasekar, V., Thomas, N., Thomas, N.K., Ticoalu, J.H.V., Tiyuri, A., Tollosa, D.N., Topor-Madry, R., Touvier, M., Tovani-Palone, M.R., Traini, E., Tran, M.T.N., Tripathy, J.P., Ukke, G.G., Ullah, I., Ullah, S., Ullah, S., Unnikrishnan, B., Vacante, M., Vaezi, M., Valadan Tahbaz, S., Valdez, P.R., Vardavas, C., Varthya, S.B., Vaziri, S., Velazquez, D.Z., Veroux, M., Villeneuve, P.J., Violante, F.S., Vladimirov, S.K., Vlassov, V., Vo, B., Vu, L.G., Wadood, A.W., Waheed, Y., Walde, M.T., Wamai, R.G., Wang, C., Wang, F., Wang, N., Wang, Y., Ward, P., Waris, A., Westerman, R., Wickramasinghe, N.D., Woldemariam, M., Woldu, B., Xiao, H., Xu, S., Xu, X., Yadav, L., Yahyazadeh Jabbari, S.H., Yang, L., Yazdanpanah, F., Yeshaw, Y., Yismaw, Y., Yonemoto, N., Younis, M.Z., Yousefi, Z., Yousefian, F., Yu, C., Yu, Y., Yunusa, I., Zahir, M., Zaki, N., Zaman, B.A., Zangiabadian, M., Zare, F., Zare, I., Zareshahrabadi, Z., Zarrintan, A., Zastrozhin, M.S., Zeineddine, M.A., Zhang, D., Zhang, J., Zhang, Y., Zhang, Z.J., Zhou, L., Zodpey, S., Zoladl, M., Vos, T., Hay, S.I., Force, L.M. and Murray, C.J.L.
Lancet 400
(10352): 563-591.
20 August 2022
Statistical analysis in the German National Cohort (NAKO) - specific aspects and general recommendations.
Kuss, O., Becher, H., Wienke, A., Ittermann, T., Ostrzinski, S., Schipf, S., Schmidt, C.O., Leitzmann, M., Pischon, T., Krist, L., Roll, S., Sand, M., Pohlabeln, H., Rach, S., Jöckel, K.H., Stang, A., Mueller, U.A., Werdecker, A., Westerman, R., Greiser, K.H. and Michels, K.B.
European Journal of Epidemiology 37
(4): 429-436.
April 2022
Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Hur, J., Otegbeye, E., Joh, H.K., Nimptsch, K., Ng, K., Ogino, S., Meyerhardt, J.A., Chan, A.T., Willett, W.C., Wu, K., Giovannucci, E. and Cao, Y.
Gut 70
(12): 2330-2336.
December 2021
Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp.
Joh, H.K., Lee, D.H., Hur, J., Nimptsch, K., Chang, Y., Joung, H., Zhang, X., Rezende, L.F.M., Lee, J.E., Ng, K., Chen, Y., Tabung, F.K., Meyerhardt, J.A., Chan, A.T., Pischon, T., Song, M., Fuchs, C.S., Willett, W.C., Cao, Y., Ogino, S., Giovannucci, E. and Wu, K.
Gastroenterology 161
(1): 128-142.
July 2021
Methodology of measuring postoperative cognitive dysfunction: a systematic review.
Borchers, F., Spies, C.D., Feinkohl, I., Brockhaus, W.R., Kraft, A., Kozma, P., Fislage, M., Kühn, S., Ionescu, C., Speidel, S., Hadzidiakos, D., Veldhuijzen, D.S., Yürek, F., Evered, L.A. and Ottens, T.H.
British Journal of Anaesthesia 126
(6): 1119-1127.
June 2021
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort.
Aglago, E.K., Huybrechts, I., Murphy, N., Casagrande, C., Nicolas, G., Pischon, T., Fedirko, V., Severi, G., Boutron-Ruault, M.C., Fournier, A., Katzke, V., Kühn, T., Olsen, A., Tjønneland, A., Dahm, C.C., Overvad, K., Lasheras, C., Agudo, A., Sánchez, M.J., Amiano, P., Huerta, J.M., Ardanaz, E., Perez-Cornago, A., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Bueno-de-Mesquita, B., May, A., Derksen, J.W.G., Hellstrand, S., Ohlsson, B., Wennberg, M., Van Guelpen, B., Skeie, G., Brustad, M., Weiderpass, E., Cross, A.J., Ward, H., Riboli, E., Norat, T., Chajes, V. and Gunter, M.J.
Clinical Gastroenterology and Hepatology 18
(3): 654-666.
March 2020
Association between physical activity and risk of hepatobiliary cancers: a multinational cohort study.
Baumeister, S.E., Schlesinger, S., Aleksandrova, K., Jochem, C., Jenab, M., Gunter, M.J., Overvad, K., Tjønneland, A., Boutron-Ruault, M.C., Carbonnel, F., Fournier, A., Kühn, T., Kaaks, R., Pischon, T., Boeing, H., Trichopoulou, A., Bamia, C., La Vecchia, C., Masala, G., Panico, S., Fasanelli, F., Tumino, R., Grioni, S., de Mesquita, B.B., Vermeulen, R., May, A.M., Borch, K.B., Oyeyemi, S.O., Ardanaz, E., Rodríguez-Barranco, M., López, M.D.C., Felez-Nobrega, M., Sonestedt, E., Ohlsson, B., Hemmingsson, O., Werner, M., Perez-Cornago, A., Ferrari, P., Stepien, M., Freisling, H., Tsilidis, K.K., Ward, H., Riboli, E., Weiderpass, E. and Leitzmann, M.F.
Journal of Hepatology 70
(5): 885-892.
May 2019
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet 392
(10159): 1923-1994.
2018
Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
Dimitrakopoulou, V.I., Tsilidis, K.K., Haycock, P.C., Dimou, N.L., Al-Dabhani, K., Martin, R.M., Lewis, S.J., Gunter, M.J., Mondul, A., Shui, I.M., Theodoratou, E., Nimptsch, K., Lindstroem, S., Albanes, D., Kuehn, T., Key, T.J., Travis, R.C., Vimaleswaran, K.S., Kraft, P., Pierce, B.L. and Schildkraut, J.M.
BMJ 359
: j4761.
31 October 2017
How to manage the obese patient with cancer.
Renehan, A.G., Harvie, M., Cutress, R.I., Leitzmann, M., Pischon, T., Howell, S. and Howell, A.
Journal of Clinical Oncology 34
(35): 4284-4294.
10 December 2016
A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
Aleksandrova, K., Chuang, S.C., Boeing, H., Zuo, H., Tell, G.S., Pischon, T., Jenab, M., Bueno-de-Mesquita, B., Vollset, S.E., Midttun, Ø., Ueland, P.M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M.C., Kaaks, R., Kühn, T., Tjønneland, A., Overvad, K., Quirós, J.R., Jakszyn, P., Sánchez, M.J., Dorronsoro, M., Chirlaque, M.D., Ardanaz, E., Khaw, K.T., Wareham, N.J., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A.M., Palmqvist, R., Ljuslinder, I., Kong, S.Y.J., Freisling, H., Gunter, M.J., Lu, Y., Cross, A.J., Riboli, E. and Vineis, P.
Journal of the National Cancer Institute 107
(4): djv010.
April 2015
Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer.
Aleksandrova, K., Boeing, H., Nöthlings, U., Jenab, M., Fedirko, V., Kaaks, R., Lukanova, A., Trichopoulou, A., Trichopoulos, D., Boffetta, P., Trepo, E., Westhpal, S., Duarte-Salles, T., Stepien, M., Overvad, K., Tjønneland, A., Halkjaer, J., Boutron-Ruault, M.C., Dossus, L., Racine, A., Lagiou, P., Bamia, C., Benetou, V., Agnoli, C., Palli, D., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, B., Peeters, P.H., Gram, I.T., Lund, E., Weiderpass, E., Quirós, J.R., Agudo, A., Sánchez, M.J., Gavrila, D., Barricarte, A., Dorronsoro, M., Ohlsson, B., Lindkvist, B., Johansson, A., Sund, M., Khaw, K.T., Wareham, N., Travis, R.C., Riboli, E. and Pischon, T.
Hepatology 60
(3): 858-871.
September 2014
Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.
Kyrø, C, Olsen, A, Landberg, R, Skeie, G, Loft, S, Åman, P, Leenders, M, Dik, VK, Siersema, PD, Pischon, T., Christensen, J, Overvad, K, Boutron-Ruault, MC, Fagherazzi, G, Cottet, V, Kühn, T, Chang-Claude, J, Boeing, H, Trichopoulou, A, Bamia, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Peeters, PH, Weiderpass, E, Bakken, T, Åsli, LA, Argüelles, M, Jakszyn, P, Sánchez, MJ, Amiano, P, Huerta, JM, Barricarte, A, Ljuslinder, I, Palmqvist, R, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Ferrari, P, Freisling, H, Jenab, M, Gunter, MJ, Murphy, N, Riboli, E, Tjønneland, A and Bueno-de-Mesquita, HB
Journal of the National Cancer Institute 106
(1): djt352.
1 January 2014
Novel biomarkers for pre-diabetes identified by metabolomics.
Wang-Sattler, R., Yu, Z., Herder, C., Messias, A.C., Floegel, A., He, Y., Heim, K., Campillos, M., Holzapfel, C., Thorand, B., Grallert, H., Xu, T., Bader, E., Huth, C., Mittelstrass, K., Doering, A., Meisinger, C., Gieger, C., Prehn, C., Roemisch-Margl, W., Carstensen, M., Xie, L., Yamanaka-Okumura, H., Xing, G., Ceglarek, U., Thiery, J., Giani, G., Lickert, H., Lin, X., Li, Y., Boeing, H., Joost, H.G., de Angelis, M.H., Rathmann, W., Suhre, K., Prokisch, H., Peters, A., Meitinger, T., Roden, M., Wichmann, H.E., Pischon, T., Adamski, J. and Illig, T.
Molecular Systems Biology 8
: 615.
25 September 2012
Editorial authors' reply to Freedhoff: "Advice to avoid low carbohydrate-high protein diets is not evidence based".
Floegel, A. and Pischon, T.
British Medical Journal 345
(7869): e5109.
6 August 2012
Low carbohydrate-high protein diets.
Floegel, A. and Pischon, T.
British Medical Journal 345
(7864): e3801.
19 June 2012
Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study.
Trichopoulos, D., Bamia, C., Lagiou, P., Fedirko, V., Trepo, E., Jenab, M., Pischon, T., Noethlings, U., Overved, K., Tjonneland, A., Outzen, M., Clavel-Chapelon, F., Kaaks, R., Lukanova, A., Boeing, H., Aleksandrova, K., Benetou, V., Zylis, D., Palli, D., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, H.B., Van Kranen, H.J., Peeters, P.H., Lund, E., Quiros, J.R., Gonzalez, C.A., Sanchez Perez, M.J., Navarro, C., Dorronsoro, M., Barricarte, A., Lindkvist, B., Regner, S., Werner, M., Hallmans, G., Khaw, K.T., Wareham, N., Key, T., Romieu, I., Chuang, S.C., Murphy, N., Boffetta, P., Trichopoulou, A. and Riboli, E.
Journal of the National Cancer Institute 103
(22): 1686-1695.
16 November 2011
Urinary sodium excretion and cardiovascular disease mortality.
Aleksandrova, K., Pischon, T. and Weikert, C.
JAMA: Journal of the American Medical Association 306
(10): 1083.
14 September 2011
Pombo, Ana (BIMSB)
Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo.
Bolesani, E., Bornhorst, D., Iyer, L.I., Zawada, D., Friese, N., Morgan, M., Lange, L., Gonzalez, D., Schrode, N., Leffler, A., Wunder, J., Franke, A., Drakhlis, L., Sebra, R., Schambach, A., Goedel, A., Dubois, N., Dobreva, G., Moretti, A., Zelarayán, L.C., Abdelilah-Seyfried, S. and Zweigerdt, R.
Cardiovascular Research 120
(11): 1295-1311.
July 2024
Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells.
Chiariello, A.M., Abraham, Alex, Bianco, S., Esposito, A., Fontana, A., Vercellone, F., Conte, M. and Nicodemi, M.
Nature Communications 15
(1): 4014.
13 May 2024
Epigenetic regulatory layers in the 3D nucleus.
Willemin, A., Szabo, D. and Pombo, A.
Molecular Cell 84
(3): 415-428.
1 February 2024
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Beagrie, R.A., Thieme, C.J., Annunziatella, C., Baugher, C., Zhang, Y., Schueler, M., Kukalev, A., Kempfer, R., Chiariello, A.M., Bianco, S., Li, Y., Davis, T., Scialdone, A., Welch, L.R., Nicodemi, M. and Pombo, A.
Nature Methods 20
(7): 1037-1047.
July 2023
Genome architecture mapping detects transcriptionally active, multiway chromatin contacts.
Thieme, C.J. and Pombo, A.
Nature Methods 20
(7): 993-994.
July 2023
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Yanchus, C., Drucker, K.L., Kollmeyer, T.M., Tsai, R., Winick-Ng, W., Liang, M., Malik, A., Pawling, J., De Lorenzo, S.B., Ali, A., Decker, P.A., Kosel, M.L., Panda, A., Al-Zahrani, K.N., Jiang, L., Browning, J.W.L., Lowden, C., Geuenich, M., Hernandez, J.J., Gosio, J.T., Ahmed, M., Loganathan, S.K., Berman, J., Trcka, D., Michealraj, K.A., Fortin, J., Carson, B., Hollingsworth, E.W., Jacinto, S., Mazrooei, P., Zhou, L., Elia, A., Lupien, M., He, H.H., Murphy, D.J., Wang, L., Abyzov, A., Dennis, J.W., Maass, P.G., Campbell, K., Wilson, M.D., Lachance, D.H., Wrensch, M., Wiencke, J., Mak, T., Pennacchio, L.A., Dickel, D.E., Visel, A., Wrana, J., Taylor, M.D., Zadeh, G., Dirks, P., Eckel-Passow, J.E., Attisano, L., Pombo, A., Ida, C.M., Kvon, E.Z., Jenkins, R.B. and Schramek, D.
Science 378
(6615): 68-78.
7 October 2022
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel, A.R., Szabo, Q., Chiariello, A.M., Chudzik, K., Schöpflin, R., Rothe, P., Mattei, A.L., Zehnder, To., Harnett, D., Laupert, V., Bianco, S., Hetzel, S., Glaser, J., Phan, M.H.Q., Schindler, M., Ibrahim, D.M., Paliou, C., Esposito, A., Prada-Medina, C.A., Haas, S.A., Giere, P., Vingron, M., Wittler, L., Meissner, A., Nicodemi, M., Cavalli, G., Bantignies, F., Mundlos, S. and Robson, M.I.
Cell 185
(20): 3689-3704.
29 September 2022
Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
Conte, M., Irani, E., Chiariello, A.M., Abraham, A., Bianco, S., Esposito, A. and Nicodemi, M.
Nature Communications 13
(1): 4070.
13 July 2022
Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W., Kukalev, A., Harabula, I., Zea-Redondo, L., Szabó, D., Meijer, M., Serebreni, L., Zhang, Y., Bianco, S., Chiariello, A.M., Irastorza-Azcarate, I., Thieme, C.J., Sparks, T.M., Carvalho, S., Fiorillo, L., Musella, F., Irani, E., Triglia, E.T., Kolodziejczyk, A.A., Abentung, A., Apostolova, G., Paul, E.J., Franke, V., Kempfer, R., Akalin, A., Teichmann, S.A., Dechant, G., Ungless, M.A., Nicodemi, M., Welch, L., Castelo-Branco, G. and Pombo, A.
Nature 599
(7886): 684-691.
25 November 2021
CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
Franke, M., De la Calle-Mustienes, E., Neto, A., Almuedo-Castillo, M., Irastorza-Azcarate, I., Acemel, R.D., Tena, J.J., Santos-Pereira, J.M. and Gómez-Skarmeta, J.L.
Nature Communications 12
(1): 5415.
13 September 2021
CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
Huang, H., Zhu, Q., Jussila, A., Han, Y., Bintu, B., Kern, C., Conte, M., Zhang, Y., Bianco, S., Chiariello, A.M., Yu, M., Hu, R., Tastemel, M., Juric, I., Hu, M., Nicodemi, M., Zhuang, X. and Ren, B.
Nature Genetics 53
(7): 1064-1074.
July 2021
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J.A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M.C., Chatelain, C., Carninci, P., de Hoon, M.J.L., Wasserman, W.W., Bréhélin, L. and Lecellier, C.H.
Nature Communications 12
(1): 3297.
2 June 2021
Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin.
Fiorillo, L., Musella, F., Conte, M., Kempfer, R., Chiariello, A.M., Bianco, S., Kukalev, A., Irastorza-Azcarate, I., Esposito, A., Abraham, A., Prisco, A., Pombo, A. and Nicodemi, M.
Nature Methods 18
(5): 482-490.
May 2021
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation.
Kubo, N., Ishii, H., Xiong, X., Bianco, S., Meitinger, F., Hu, R., Hocker, J.D., Conte, M., Gorkin, D., Yu, M., Li, B., Dixon, J.R., Hu, M., Nicodemi, M., Zhao, H. and Ren, B.
Nature Structural & Molecular Biology 28
(2): 152-161.
February 2021
Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Alcalá-Vida, R., Seguin, J., Lotz, C., Molitor, A.M., Irastorza-Azcarate, I., Awada, A., Karasu, N., Bombardier, A., Cosquer, B., Skarmeta, J.L.G., Cassel, J.C., Boutillier, A.L., Sexton, T. and Merienne, K.
Nature Communications 12
(1): 364.
13 January 2021
LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X.M., Figlerowicz, M., Gasser, S.M., Hubner, N., Kjems, J., Knoblich, J.A., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J.C., Marioni, J., Marti-Renom, M.A., Netea, M.G., Nickel, D., Nollmann, M., Novak, H.R., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J.L., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F.J., Torres-Padilla, M.E., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M. and Voet, T.
Nature 587
(7834): 377-386.
19 November 2020
Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
Conte, M., Fiorillo, L., Bianco, S., Chiariello, A.M., Esposito, A. and Nicodemi, M.
Nature Communications 11
(1): 3289.
3 July 2020
Methods for mapping 3D chromosome architecture.
Kempfer, R. and Pombo, A.
Nature Reviews Genetics 21
(4): 207-226.
April 2020
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Dellino, G.I., Palluzzi, F., Chiariello, A.M., Piccioni, R., Bianco, S., Furia, L., De Conti, G., Bouwman, B.A.M., Melloni, G., Guido, D., Giacò, L., Luzi, L., Cittaro, D., Faretta, M., Nicodemi, M., Crosetto, N. and Pelicci, P.G.
Nature Genetics 51
(6): 1011-1023.
June 2019
R-loops enhance polycomb repression at a subset of developmental regulator genes.
Skourti-Stathaki, K., Torlai Triglia, E., Warburton, M., Voigt, P., Bird, A. and Pombo, A.
Molecular Cell 73
(5): 930-945.
7 March 2019
Challenges and guidelines toward 4D nucleome data and model standards.
Marti-Renom, M.A., Almouzni, G., Bickmore, W.A., Bystricky, K., Cavalli, G., Fraser, P., Gasser, S.M., Giorgetti, L., Heard, E., Nicodemi, M., Nollmann, M., Orozco, M., Pombo, A. and Torres-Padilla, M.E.
Nature Genetics 50
(10): 1352-1358.
October 2018
Polymer physics predicts the effects of structural variants on chromatin architecture.
Bianco, S., Lupiáñez, D.G., Chiariello, A.M., Annunziatella, C., Kraft, K., Schöpflin, R., Wittler, L., Andrey, G., Vingron, M., Pombo, A., Mundlos, S. and Nicodemi, M.
Nature Genetics 50
(5): 662-667.
May 2018
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E., Menegatti, J., Franke, V., Kocks, C., Boltengagen, A., Hennig, T., Theil, K., Rutkowski, A., Ferrai, C., Baer, L., Kermas, L., Friedel, C., Rajewsky, N., Akalin, A., Dölken, L., Grässer, F. and Landthaler, M.
Genome Biology 18
(1): 209.
31 October 2017
The 4D nucleome project.
Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J. and Zhong, S.
Nature 549
(7671): 219-226.
14 September 2017
Cell cycle: continuous chromatin changes.
Beagrie, R.A. and Pombo, A.
Nature 547
(7661): 34-35.
6 July 2017
Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.
Kar, G., Kim, J.K., Kolodziejczyk, A.A., Natarajan, K.N., Torlai Triglia, E., Mifsud, B., Elderkin, S., Marioni, J.C., Pombo, A. and Teichmann, S.A.
Nature Communications 8
(1): 36.
26 June 2017
Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.
Barbieri, M., Xie, S.Q., Torlai Triglia, E., Chiariello, A.M., Bianco, S., de Santiago, I., Branco, M.R., Rueda, D., Nicodemi, M. and Pombo, A.
Nature Structural & Molecular Biology 24
(6): 515-524.
June 2017
Keep them close: PRC2 poises enhancer-promoter interactions at anterior neuronal genes.
Caglio, Giulia, Torlai Triglia, E. and Pombo, A.
Cell Stem Cell 20
(5): 573-575.
4 May 2017
Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie, R.A., Scialdone, A., Schueler, M., Kraemer, D.C.A., Chotalia, M., Xie, S.Q., Barbieri, M., de Santiago, I., Lavitas, L.M., Branco, M.R., Fraser, J., Dostie, J., Game, L., Dillon, N., Edwards, P.A.W., Nicodemi, M. and Pombo, A.
Nature 543
(7646): 519-524.
23 March 2017
A finer print than TADs: PRC1-mediated domains.
Torlai Triglia, E., Rito, Tiago and Pombo, A.
Molecular Cell 65
(3): 373-375.
2 February 2017
Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke, M., Ibrahim, D.M., Andrey, G., Schwarzer, W., Heinrich, V., Schoepflin, R., Kraft, K., Kempfer, R., Jerkovic, I., Chan, W.L., Spielmann, M., Timmermann, B., Wittler, L., Kurth, I., Cambiaso, P., Zuffardi, O., Houge, G., Lambie, L., Brancati, F., Pombo, A., Vingron, M., Spitz, F. and Mundlos, S.
Nature 538
(7624): 265-269.
13 October 2016
Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.
Le, H.Q., Ghatak, S., Yeung, C.Y.C., Tellkamp, F., Günschmann, C., Dieterich, C., Yeroslaviz, A., Habermann, B., Pombo, A., Niessen, C.M. and Wickström, S.A.
Nature Cell Biology 18
(8): 864-875.
August 2016
Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.
Fraser, J., Ferrai, C., Chiariello, A.M., Schueler, M., Rito, T., Laudanno, G., Barbieri, M., Moore, B.L., Kraemer, D.C.A., Aitken, S., Xie, S.Q., Morris, K.J., Itoh, M., Kawaji, H., Jaeger, I., Hayashizaki, Y., Carninci, P., Forrest, A.R.R., Semple, C.A., Dostie, J., Pombo, A. and Nicodemi, M.
Molecular Systems Biology 11
(12): 852.
23 December 2015
Three-dimensional genome architecture: players and mechanisms.
Pombo, A. and Dillon, N.
Nature Reviews Molecular Cell Biology 16
(4): 245-257.
April 2015
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner, E., Daub, C.O., Vitting-Seerup, K., Andersson, R., Lilje, B., Drabløs, F., Lennartsson, A., Rönnerblad, M., Hrydziuszko, O., Vitezic, M., Freeman, T.C., Alhendi, A., Arner, P., Axton, R., Baillie, J.K., Beckhouse, A., Bodega, B., Briggs, J., Brombacher, F., Davis, M., Detmar, M., Ehrlund, A., Endoh, M., Eslami, A., Fagiolini, M., Fairbairn, L., Faulkner, G.J., Ferrai, C., Fisher, M.E., Forrester, L., Goldowitz, D., Guler, R., Ha, T., Hara, M., Herlyn, M., Ikawa, T., Kai, C., Kawamoto, H., Khachigian, L., Klinken, P.S., Kojima, S., Koseki, H., Klein, S., Mejhert, N., Miyaguchi, K., Mizuno, Y., Morimoto, M., Morris, K.J., Mummery, C., Nakachi, Y., Ogishima, S., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D., Passier, R., Patrikakis, M., Pombo, A., Qin, X.Y., Roy, S., Sato, H., Savvi, S., Saxena, A., Schwegmann, A., Sugiyama, D., Swoboda, R., Tanaka, H., Tomoiu, A., Winteringham, L.N., Wolvetang, E., Yanagi-Mizuochi, C., Yoneda, M., Zabierowski, S., Zhang, P., Abugessaisa, I., Bertin, N., Diehl, A.D., Fukuda, S., Furuno, M., Harshbarger, J., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Ishizu, Y., Itoh, M., Kawashima, T., Kojima, M., Kondo, N., Lizio, M., Meehan, T.F., Mungall, C.J., Murata, M., Nishiyori-Sueki, H., Sahin, S., Sato-Nagao, S., Severin, J., de Hoon, M.J., Kawai, J., Kasukawa, T., Lassmann, T., Suzuki, H., Kawaji, H., Summers, K.M., Wells, C., Hume, D.A., Forrest, A.R.R., Sandelin, A., Carninci, P. and Hayashizaki, Y.
Science 347
(6225): 1010-1014.
27 February 2015
Stem cell epigenetics: looking forward.
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Lim, D.A., Meshorer, E., Pombo, A., Sander, M. and Xu, G.L.
Cell Stem Cell 14
(6): 706-709.
5 June 2014
Poole, Kathryn
Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
Grandin, M., Meier, M., Delcros, J.G., Nikodemus, D., Reuten, R., Patel, T.R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., Abes, R., Dean, Y., Neves, D., Bernet, A., Depil, S., Schneiders, F., Poole, K., Dante, R., Koch, M., Mehlen, P. and Stetefeld, J.
Cancer Cell 29
(2): 173-185.
8 February 2016
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Chiang, L.Y., Poole, K., Oliveira, B.E., Duarte, N., Bernal Sierra, Y.A., Bruckner-Tuderman, L., Koch, M., Hu, J. and Lewin, G.R.
Nature Neuroscience 14
(8): 993-1000.
3 July 2011
The molecular and cellular identity of peripheral osmoreceptors.
Lechner, S.G., Markworth, S., Poole, K., Smith, E.S.J., Lapatsina, L., Frahm, S., May, M., Pischke, S., Suzuki, M., Ibanez-Tallon, I., Luft, F.C., Jordan, J. and Lewin, G.R.
Neuron 69
(2): 332-344.
27 January 2011
Potente, Michael (MDC/BIH)
iSuRe-HadCre is an essential tool for effective conditional genetics.
Garcia-Gonzalez, I., Rocha, S.F., Hamidi, A., Garcia-Ortega, L., Regano, A., Sanchez-Muñoz, M.S., Lytvyn, M., Garcia-Cabero, A., Roig-Soucase, S., Schoofs, H., Castro, M., Sabata, H., Potente, M., Graupera, M., Makinen, T. and Benedito, R.
Nucleic Acids Research 52
(13): e56.
22 July 2024
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li, X., Wu, F., Günther, S., Looso, M., Kuenne, C., Zhang, T., Wiesnet, M., Klatt, S., Zukunft, S., Fleming, I., Poschet, G., Wietelmann, A., Atzberger, A., Potente, M., Yuan, X. and Braun, T.
Nature 622
(7983): 619-626.
19 October 2023
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong, Y.T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A.S.H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., Lim, J., Watanabe, S., Guenther, S., Schneider, A., Zanconato, F., Kaulich, M., Pan, D., Braun, T., Gerhardt, H., Efeyan, A., Carmeliet, P., Piccolo, S., Grosso, A.R. and Potente, M.
Nature Metabolism 4
(6): 672-682.
June 2022
The blood-brain barrier-a metabolic ecosystem.
Castro, M. and Potente, M.
EMBO Journal 41
(9): e111189.
2 May 2022
Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
Kaneshige, A., Kaji, T., Zhang, L., Saito, H., Nakamura, A., Kurosawa, T., Ikemoto-Uezumi, M., Tsujikawa, K., Seno, S., Hori, M., Saito, Y., Matozaki, T., Maehara, K., Ohkawa, Y., Potente, M., Watanabe, S., Braun, T., Uezumi, A. and Fukada, S.I.
Cell Stem Cell 29
(2): 265-280.
3 February 2022
Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
Heumüller, A.W., Jones, A. N., Mourão, A., Klangwart, M., Shi, C., Wittig, I., Fischer, A., Muhly Reinholz, M., Buchmann, G.K., Dieterich, C., Potente, M., Braun, T., Grote, P., Jaé, N., Sattler, M. and Dimmeler, S.
Circulation Research 130
(1): 67-79.
7 January 2022
Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J., Luxán, G., Abplanalp, W.T., Glaser, S.F., Rasper, T., Fischer, A., Muhly-Reinholz, M., Potente, M., Assmus, B., John, D., Zeiher, A.M. and Dimmeler, S.
Nature Communications 12
(1): 3964.
25 June 2021
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren, A.A., Snellings, D.A., Su, Y.S., Hong, C.C., Castro, M., Tang, A.T., Detter, M.R., Hobson, N., Girard, R., Romanos, S., Lightle, R., Moore, T., Shenkar, R., Benavides, C., Beaman, M.M., Mueller-Fielitz, H., Chen, M., Mericko, P., Yang, J., Sung, D.C., Lawton, M.T., Ruppert, M., Schwaninger, M., Körbelin, J., Potente, M., Awad, I.A., Marchuk, D.A. and Kahn, M.L.
Nature 594
(7862): :271-276.
10 June 2021
Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J., Shi, C., Costa, A.S.H., Choi, J., Kim, J., Doddaballapur, A., Sugino, T., Ong, Y.T., Castro, M., Zimmermann, B., Kaulich, M., Guenther, S., Wilhelm, K., Kubota, Y., Braun, T., Koh, G.Y., Grosso, A.R., Frezza, C. and Potente, M.
Nature Cell Biology 23
: 413-423.
April 2021
Arterialization requires the timely suppression of cell growth.
Luo, W., Garcia-Gonzalez, I., Fernández-Chacón, M., Casquero-Garcia, V., Sanchez-Muñoz, M.S., Mühleder, S., Garcia-Ortega, L., Andrade, J., Potente, M. and Benedito, R.
Nature 589
(7842): 437-441.
21 January 2021
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M.F., Lim, R., Zimmermann, B., Aspalter, I.M., Franco, C.A., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K., Keller, C., Brüning, J.C., Gerhardt, H., Carmeliet, P. and Potente, M.
Nature 529
(7585): 216-220.
14 January 2016
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Vinals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M.
Nature Communications 6
: 7935.
31 July 2015
Poulet, James
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15
(1): 898.
6 February 2024
The cellular coding of temperature in the mammalian cortex.
Vestergaard, M., Carta, M., Güney, G. and Poulet, J.F.A.
Nature 614
(7949): 725-731.
23 February 2023
The brain's encoding of warm and cool.
Vestergaard, M. and Poulet, J.
Nature
8 February 2023
(In Press)
Deep tissue scattering compensation with three-photon F-SHARP.
Berlage, C., Tantirigama, M.L.S., Babot, M., Di Battista, D., Whitmire, C., Papadopoulos, I.N., Poulet, J.F.A., Larkum, M. and Judkewitz, B.
Optica 8
(12): 1613-1619.
20 December 2021
A medullary centre for lapping in mice.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
Nature Communications 12
: 6307.
2 November 2021
USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Schwaller, F., Bégay, V., García-García, G., Taberner, F.J., Moshourab, R., McDonald, B., Docter, T., Kühnemund, J., Ojeda-Alonso, J., Paricio-Montesinos, R., Lechner, S.G., Poulet, J.F.A., Millan, J.M. and Lewin, G.R.
Nature Neuroscience 24
(1): 74-81.
January 2021
Dynamic conjugate F-SHARP microscopy.
Papadopoulos, I.N., Jouhanneau, J.S., Takahashi, N., Kaplan, D., Larkum, M., Poulet, J. and Judkewitz, B.
Light: Science & Applications 9
(1): 110.
30 June 2020
The sensory coding of warm perception.
Paricio-Montesinos, R., Schwaller, F., Udhayachandran, A., Rau, F., Walcher, J., Evangelista, R., Vriens, J., Voets, T., Poulet, J.F.A. and Lewin, G.R.
Neuron 106
(5): 830-841.
3 June 2020
Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T., Braud, S., Jüttner, R., Voigt, B.C., Paulick, K., Sheean, M.E., Klisch, C., Gueneykaya, D., Rathjen, F.G., Geiger, J.R.P., Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37
(17): e98858.
3 September 2018
Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo.
Jouhanneau, J.S., Kremkow, J. and Poulet, J.F.A.
Nature Communications 9
(1): 1540.
18 April 2018
Precisely timed nicotinic activation drives SST inhibition in neocortical circuits.
Urban-Ciecko, J., Jouhanneau, J.S., Myal, S.E., Poulet, J.F.A. and Barth, A.L.
Neuron 97
(3): 611-625.
7 February 2018
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
Scattering compensation by focus scanning holographic aberration probing (F-SHARP).
Papadopoulos, I.N., Jouhanneau, J.S., Poulet, J.F.A. and Judkewitz, B.
Nature Photonics 11
(2): 116-123.
February 2017
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20
(2): 209-218.
February 2017
Matching cell type to function in cortical circuits.
Estebanez, L., Kremkow, J. and Poulet, J.F.A.
Neuron 87
(2): 249-251.
15 July 2015
Cortical fosGFP expression reveals broad receptive field excitatory neurons targeted by POm.
Jouhanneau, J.S., Ferrarese, L., Estebanez, L., Audette, N.J., Brecht, M., Barth, AL. and Poulet, J.F.A.
Neuron 84
(5): 1065-1078.
3 December 2014
A somatosensory circuit for cooling perception in mice.
Milenkovic, N., Zhao, W.J., Walcher, J., Albert, T., Siemens, J., Lewin, G.R. and Poulet, J.F.A.
Nature Neuroscience 17
(11): 1560-1566.
November 2014
Keeping an eye on cortical States.
Poulet, J.F.A.
Neuron 84
(2): 246-248.
22 October 2014
Barrel cortex function.
Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C.C.H., Poulet, J.F.A., Staiger, J.F., Luhmann, H.J. and Schwarz, C.
Progress in Neurobiology 103
: 3-27.
April 2013
Experimental evidence for sparse firing in the neocortex.
Barth, A.L. and Poulet, J.F.A.
Trends in Neurosciences 35
(6): 345-355.
June 2012
Thalamic control of cortical states.
Poulet, J.F.A., Fernandez, L.M.J., Crochet, S. and Petersen, C.C.H.
Nature Neuroscience 15
(3): 370-372.
22 January 2012
Coherent phasic excitation during hippocampal ripples.
Maier, N., Tejero-Cantero, A., Dorrn, A.L., Winterer, J., Beed, P.S., Morris, G., Kempter, R., Poulet, J.F.A., Leibold, C. and Schmitz, D.
Neuron 72
(1): 137-152.
6 October 2011
Synaptic mechanisms underlying sparse coding of active touch.
Crochet, S., Poulet, J.F.A., Kremer, Y. and Petersen, C.C.H.
Neuron 69
(6): 1160-1175.
24 March 2011
An embedded subnetwork of highly active neurons in the neocortex.
Yassin, L., Benedetti, B.L., Jouhanneau, J.S., Wen, J.A., Poulet, J.F.A. and Barth, A.L.
Neuron 68
(6): 1043-1050.
22 December 2010
Developmental sensory experience balances cortical excitation and inhibition.
Dorrn, A.L., Yuan, K., Barker, A.J., Schreiner, C.E. and Froemke, R.C.
Nature 465
(7300): 932-936.
17 June 2010
Poy, Matthew
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh, Y.T., Sona, C., Yan, X., Li, Y., Pathak, A., McDermott, M.I., Xie, Z., Liu, L., Arunagiri, A., Wang, Y., Cazenave-Gassiot, A., Ghosh, A., von Meyenn, F., Kumarasamy, S., Najjar, S.M., Jia, S., Wenk, M.R., Traynor-Kaplan, A., Arvan, P., Barg, S., Bankaitis, V.A. and Poy, M.N.
Nature Communications 14
(1): 4250.
17 July 2023
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M.N., Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126
(7): 2706-2720.
1 July 2016
Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Tattikota, S.G., Rathjen, T., McAnulty, S.J., Wessels, H.H., Akerman, I., van de Bunt, M., Hausser, J., Esguerra, J.L.S., Musahl, A., Pandey, A.K., You, X., Chen, W., Herrera, P.L., Johnson, P.R., O'Carroll, D., Eliasson, L., Zavolan, M., Gloyn, A.L., Ferrer, J., Shalom-Feuerstein, R., Aberdam, D. and Poy, M.N.
Cell Metabolism 19
(1): 122-134.
7 January 2014
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton, M., Levin, A., Slyper, M., Alkalay, I., Horwitz, E., Mor, H., Kredo-Russo, S., Avnit-Sagi, T., Cojocaru, G., Zreik, F., Bentwich, Z., Poy, M.N., Artis, D., Walker, M.D., Hornstein, E., Pikarsky, E. and Ben-Neriah, Y.
Nature Immunology 12
(3): 239-246.
March 2011
Preibisch, Stephan (BIMSB)
Best practice standards for circular RNA research.
Nielsen, A.F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T.B., Irimia, M., Kadener, S., Kristensen, L.S., Legnini, I., Morlando, M., Jarlstad Olesen, M.T., Pasterkamp, R.J., Preibisch, S., Rajewsky, N., Suenkel, C. and Kjems, J.
Nature Methods 19
(10): 1208-1220.
October 2022
Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.
Le Poul, Y., Xin, Y., Ling, L., Mühling, B., Jaenichen, R., Hörl, D., Bunk, D., Harz, H., Leonhardt, H., Wang, Y., Osipova, E., Museridze, M., Dharmadhikari, D., Murphy, E., Rohs, R., Preibisch, S., Prud'homme, B. and Gompel, N.
Science Advances 6
(49): eabe2955.
2 December 2020
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
Hörl, D., Rojas Rusak, F., Preusser, F., Tillberg, P., Randel, N., Chhetri, R.K., Cardona, A., Keller, P.J., Harz, H., Leonhardt, H., Treier, M. and Preibisch, S.
Nature Methods 16
(9): 870-874.
September 2019
Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.
Vladimirov, N., Wang, C., Höckendorf, B., Pujala, A., Tanimoto, M., Mu, Y., Yang, C.T., Wittenbach, J.D., Freeman, J., Preibisch, S., Koyama, M., Keller, P.J. and Ahrens, M.B.
Nature Methods 15
(12): 1117-1125.
December 2018
Preissner, Robert
Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O., Zincke, F., Eckert, A., Kobelt, D., Preissner, S., Liebeskind, J.M., Gunkel, N., Putzker, K., Lewis, J., Preissner, S., Kortüm, B., Walther, W., Mura, K., Bourne, P.E., Stein, U. and Preissner, R.
Clinical and Translational Medicine 12
(2): e726.
20 February 2022
Prigione, Alessandro
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T., Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M., Zink, A., Chondrogianni, N., Psomopoulos, F., Prigione, A., Ivics, Z., Pospisilova, S., Skladal, P., Izsvák, Z., Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A., Buntru, A., Arnsburg, K., Ast, A., Iburg, M., Juenemann, K., Pigazzini, M.L., Mlody, B., Puchkov, D., Priller, J., Wanker, E.E., Prigione, A. and Kirstein, J.
EMBO Journal 37
(2): 282-299.
17 January 2018
Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49
: 71-76.
December 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
A glycolytic solution for pluripotent stem cells.
Mlody, B. and Prigione, A.
Cell Stem Cell 19
(4): 419-420.
6 October 2016
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
(2): 327-346.
February 2016
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A., Prigione, A., Cramer, T., Wamelink, M.M.C., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N.M., Krueger, A., Tauqeer Alam, M., Keller, M.A., Breitenbach, M., Brindle, K.M., Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90
(3): 927-963.
August 2015
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
Purfuerst, Bettina
Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C., Dietert, K., Schotsaert, M., Martínez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M., Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S., Gruber, A.D., Hoetzenecker, W., Steinkellner, H., Purfuerst, B., Motz, R., Di Pierro, F., Lamprecht, B., Osterrieder, N., Landthaler, M., Drosten, C., García-Sastre, A., Langer, R., Ralser, M., Eils, R., Reimann, M., Fan, D.N.Y. and Schmitt, C.A.
Nature 599
: 283-289.
11 November 2021
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11
(1): 929.
17 February 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Faelber, K., Dietrich, L., Noel, J.K., Wollweber, F., Pfitzner, A.K., Mühleip, A., Sánchez, R., Kudryashev, M., Chiaruttini, N., Lilie, H., Schlegel, J., Rosenbaum, E., Hessenberger, M., Matthaeus, C., Kunz, S., von der Malsburg, A., Noé, F., Roux, A., van der Laan, M., Kühlbrandt, W. and Daumke, O.
Nature 571
(7765): 429-433.
18 July 2019
mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A., Buntru, A., Schindler, F., Hasenkopf, R., Schulz, A., Brusendorf, L., Klockmeier, K., Grelle, G., McMahon, B., Niederlechner, H., Jansen, I., Diez, L., Edel, J., Boeddrich, A., Franklin, S.A., Baldo, B., Schnoegl, S., Kunz, S., Purfürst, B., Gaertner, A., Kampinga, H.H., Morton, A.J., Petersén, Å., Kirstein, J., Bates, G.P. and Wanker, E.E.
Molecular Cell 71
(5): 675-688.
6 September 2018
Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M., Zerbes, R.M., Rampelt, H., Kunz, S., Xavier, A.H., Purfürst, B., Lilie, H., Pfanner, N., van der Laan, M. and Daumke, O.
Nature Communications 8
: 15258.
31 May 2017
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J., Bezzina, C.R., Freiberg, F., Verkerk, A.O., Adriaens, M.E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T.T., Baczko, I., Dos Remedios, C.G., George, A.L., Bishopric, N.H., Lodder, E.M., de Bakker, J.M.T., Fischer, R., Coronel, R., Wilde, A.A.M., Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63
(6): 549-559.
18 February 2014
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D., Vasyutina, E., Czajkowski, M.T., Griger, J., Rassek, C., Rahn, H.P., Purfürst, B., Wende, H. and Birchmeier, C.
Developmental Cell 23
(3): 469-481.
11 September 2012
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E.S.J., Wend, P., Purfürst, B., Nuber, U.A., Gurok, U., Matyash, V., Waelzlein, J.H., Chirasani, S.R., Dittmar, G., Cravatt, B.F., Momma, S., Lewin, G.R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H. and Glass, R.
Nature Medicine 18
(8): 1232-1238.
August 2012
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B., Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14
(1): 54-61.
January 2011
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J., Lu, Y., Jüttner, R., Smith, E.S.J., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. and Lewin, G.R.
PLoS Biology 6
(1): e13.
29 January 2008
Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N., Frahm, C., Gassmann, M., Griffel, C., Erdmann, B., Birchmeier, C., Lewin, G.R. and Garratt, A.N.
Neuron 56
(5): 893-906.
6 December 2007
A stomatin-domain protein essential for touch sensation in the mouse.
Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Harder, L., Eilers, A., Moshourab, R., Kozlenkov, A., Labuz, D., Caspani, O., Erdmann, B., Machelska, H., Heppenstall, P.A. and Lewin, G.R.
Nature 445
(7124): 206-209.
11 January 2007
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S., Bergmann, N., Luo, X., Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173
(4): 559-570.
22 May 2006
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 167
(1): 149-160.
11 October 2004
Rahn, Hans-Peter
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D., Vasyutina, E., Czajkowski, M.T., Griger, J., Rassek, C., Rahn, H.P., Purfürst, B., Wende, H. and Birchmeier, C.
Developmental Cell 23
(3): 469-481.
11 September 2012
Rajewsky, Klaus
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T., Graf, R., Acevedo-Ochoa, E., Trombke, J., Weber, T., Sommermann, T., Salomon, C., Kühn, R., Rajewsky, K. and Chu, V.T.
Leukemia 38
(9): 2003-2015.
September 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9
(92): eadi0042.
2 February 2024
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler, F., Ostertag, M.S., Sommermann, T., Weidl, D., Sterz, K.R., Kutz, H., Moosmann, A., Feller, S.M., Geerlof, A., Biesinger, B., Popowicz, G.M., Kirchmair, J. and Kieser, A.
Nature Communications 15
(1): 414.
10 January 2024
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14
(1): 6947.
7 November 2023
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Griger, J., Widholz, S.A., Jesinghaus, M., de Andrade Krätzig, N., Lange, S., Engleitner, T., Montero, J.J., Zhigalova, E., Öllinger, R., Suresh, V., Winkler, W., Lier, S., Baranov, O., Trozzo, R., Ben Khaled, N., Chakraborty, S., Yu, J., Konukiewitz, B., Steiger, K., Pfarr, N., Rajput, A., Sailer, D., Keller, G., Schirmacher, P., Röcken, C., Fagerstedt, K.W., Mayerle, J., Schmidt-Supprian, M., Schneider, G., Weichert, W., Calado, D.P., Sommermann, T., Klöppel, G., Rajewsky, K., Saur, D. and Rad, R.
Cancer Cell 41
(7): 1327-1344.e10.
10 July 2023
B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
Schmid, V.K., Khadour, A., Ahmed, N., Brandl, C., Nitschke, L., Rajewsky, K., Jumaa, H. and Hobeika, E.
Haematologica 107
(8): 1796-1814.
August 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K. and Chu, V.T.
Science Advances 8
(22): eabm9106.
3 June 2022
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P., Song, T., Yao, Y., Fehlner-Peach, H., Diamond, B., Gu, H., Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118
(30): e2100576118.
27 July 2021
CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T., Graf, R., Wulf-Goldenberg, A., Stecklum, M., Strauß, G., Kühn, R., Kocks, C., Rajewsky, K. and Chu, V.T.
Molecular Therapy 28
(12): 2621-2634.
2 December 2020
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T., Yasuda, T., Ronen, J., Wirtz, T., Weber, T., Sack, U., Caeser, R., Zhang, J., Li, X., Chu, V.T., Jauch, A., Unger, K., Hodson, D.J., Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117
(25): 14421-14432.
23 June 2020
The advent and rise of monoclonal antibodies.
Rajewsky, K.
Nature 575
(7781): 47-49.
November 2019
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B., Hewitt, S.L., Heltemes-Harris, L.M., Mandal, M., Johnson, K., Rajewsky, K., Koralov, S.B., Clark, M.R., Farrar, M.A. and Skok, J.A.
Nature Communications 10
(1): 4768.
18 October 2019
BCR-dependent lineage plasticity in mature B cells.
Graf, R., Seagal, J., Otipoby, K.L., Lam, K.P., Ayoub, S., Zhang, B., Sander, S., Chu, V.T. and Rajewsky, K.
Science 363
(6428): 748-753.
15 February 2019
Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
Kabrani, E., Chu, V.T., Tasouri, E., Sommermann, T., Baßler, K., Ulas, T., Zenz, T., Bullinger, L., Schultze, J.L., Rajewsky, K. and Sander, S.
Blood 132
(25): 2670-2683.
20 December 2018
Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T., Blankenstein, T. and Willimsky, G.
Blood 132
(9): 924-934.
30 August 2018
Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., Levin-Klein, R., Goren, A., Rajewsky, K., Kaestner, K.H. and Cedar, H.
Nature Communications 9
(1): 2040.
23 May 2018
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G., Raffel, S., Sormani, M., Zanardi, F., Lonardi, S., Zasada, C., Perucho, L., Petrocelli, V., Haake, A., Lee, A.K., Bugatti, M., Paul, U., Van Anken, E., Pasqualucci, L., Rabadan, R., Siebert, R., Kempa, S., Ponzoni, M., Facchetti, F., Rajewsky, K. and Casola, S.
Nature 546
(7657): 302-306.
8 June 2017
miR-23~27~24 clusters control effector T cell differentiation and function.
Cho, S., Wu, C.J., Yasuda, T., Cruz, L.O., Khan, A.A., Lin, L.L., Nguyen, D.T., Miller, M., Lee, H.M., Kuo, M.L., Broide, D.H., Rajewsky, K., Rudensky, A.Y. and Lu, L.F.
Journal of Experimental Medicine 213
(2): 235-249.
8 February 2016
Immunological memory: lessons from the past and a look to the future.
Farber, D.L., Netea, M.G., Radbruch, A., Rajewsky, K. and Zinkernagel, R.M.
Nature Reviews Immunology 16
(2): 124-128.
February 2016
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M.F., Lim, R., Zimmermann, B., Aspalter, I.M., Franco, C.A., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K., Keller, C., Brüning, J.C., Gerhardt, H., Carmeliet, P. and Potente, M.
Nature 529
(7585): 216-220.
14 January 2016
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S., Chu, V.T., Yasuda, T., Franklin, A., Graf, R., Calado, D.P., Li, S., Imami, K., Selbach, M., Di Virgilio, M., Bullinger, L. and Rajewsky, K.
Immunity 43
(6): 1075-1086.
15 December 2015
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J.L., Goossens, N., Nakagawa, S., Gunasekaran, G., Schwartz, M.E., Kobayashi, M., Kumada, H., Berger, M., Pappo, O., Rajewsky, K., Hoshida, Y., Karin, M., Heikenwalder, M., Ben-Neriah, Y. and Pikarsky, E.
Nature Immunology 16
(12): 1235-1244.
December 2015
Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. and Chu, V.T.
Genome Biology 16
(1): 244.
10 November 2015
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K. and Kühn, R.
Nature Biotechnology 33
(5): 543-548.
May 2015
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P., Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K., Sleckman, B.P., de Alboran, I.M., Janz, M., Rodig, S. and Rajewsky, K.
Nature Immunology 13
(11): 1092-1100.
November 2012
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K. and Takemori, T.
Journal of Experimental Medicine 209
(11): 2079-2097.
22 October 2012
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Sander, S., Calado, D.P., Srinivasan, L., Köchert, K., Zhang, B., Rosolowski, M., Rodig, S.J., Holzmann, K., Stilgenbauer, S., Siebert, R., Bullinger, L. and Rajewsky, K.
Cancer Cell 22
(2): 167-179.
14 August 2012
Rajewsky, Nikolaus (BIMSB)
Challenges and opportunities in the clinical translation of high-resolution spatial transcriptomics.
Pentimalli, T.M., Karaiskos, N. and Rajewsky, N.
Annual Review of Pathology : Mechanisms of Disease
30 October 2024
(In Press)
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Open-ST: high-resolution spatial transcriptomics in 3D.
Schott, M., León-Periñán, D., Splendiani, E., Strenger, L., Licha, J.R., Pentimalli, T.M., Schallenberg, S., Alles, J., Samut Tagliaferro, S., Boltengagen, A., Ehrig, S., Abbiati, S., Dommerich, S., Pagani, M., Ferretti, E., Macino, G., Karaiskos, N. and Rajewsky, N.
Cell 187
(15): 3953-3972.e26.
25 July 2024
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20
(10): 1544-1552.
October 2023
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14
(1): 3936.
4 July 2023
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8
(7): 1252-1266.
July 2023
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.
Piwecka, M., Rajewsky, N. and Rybak-Wolf, A.
Nature Reviews Neurology 19
(6): 346–362.
June 2023
Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H.C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N. and Hilgers, V.
Cell 186
(11): 2438-2455.
25 May 2023
Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14
(1): 3025.
25 May 2023
Curvature in biological systems: its quantification, emergence and implications across the scales.
Schamberger, B., Roschger, A., Ziege, R., Anselme, K., Amar, M.B., Bykowski, M., Castro, A.P.G., Cipitria, A., Coles, R., Dimova, R., Eder, M., Ehrig, S., Escudero, L.M., Evans, M.E., Fernandes, P.R., Fratzl, P., Geris, L., Gierlinger, N., Hannezo, E., Iglič, A., Kirkensgaard, J.J.K., Kollmannsberger, P., Kowalewska, Ł., Kurniawan, N.A., Papantoniou, I., Pieuchot, L., Pires, T.H.V., Renner, L., Sageman-Furnas, A., Schröder-Turk, G.E., Sengupta, A., Sharma, V.R., Tagua, A., Tomba, C., Trepat, X., Waters, S.L., Yeo, E., Bidan, C.M. and Dunlop, J.W.C.
Advanced Materials 35
(13): e2206110.
15 March 2023
A guide to naming eukaryotic circular RNAs.
Chen, L.L., Bindereif, A., Bozzoni, I., Chang, H.Y., Matera, A.G., Gorospe, M., Hansen, T.B., Kjems, J., Ma, X.K., Pek, J.W., Rajewsky, N., Salzman, J., Wilusz, J.E., Yang, L. and Zhao, F.
Nature Cell Biology 25
(1): 1-5.
January 2023
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J., Kim, S.J., Skopnik, C.M., Hinze, C., Boltengagen, A., Metzke, D., Grothgar, E., Prskalo, L., Wagner, L., Freund, P., Görlich, N., Muench, F., Schmidt-Ott, K.M., Mashreghi, M.F., Kocks, C., Eckardt, K.U., Rajewsky, N. and Enghard, P.
Kidney International 102
(6): 1359-1370.
December 2022
Cell type diversity in a developing octopus brain.
Styfhals, R., Zolotarov, G., Hulselmans, G., Spanier, K.I., Poovathingal, S., Elagoz, A.M., De Winter, S., Deryckere, A., Rajewsky, N., Ponte, G., Fiorito, G., Aerts, S. and Seuntjens, E.
Nature Communications 13
(1): 7392.
30 November 2022
MicroRNAs are deeply linked to the emergence of the complex octopus brain.
Zolotarov, G., Fromm, B., Legnini, I., Ayoub, S., Polese, G., Maselli, V., Chabot, P.J., Vinther, J., Styfhals, R., Seuntjens, E., Di Cosmo, A., Peterson, K.J. and Rajewsky, N.
Science Advances 8
(47): eadd9938.
25 November 2022
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27
(43): 2101089.
27 October 2022
Best practice standards for circular RNA research.
Nielsen, A.F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T.B., Irimia, M., Kadener, S., Kristensen, L.S., Legnini, I., Morlando, M., Jarlstad Olesen, M.T., Pasterkamp, R.J., Preibisch, S., Rajewsky, N., Suenkel, C. and Kjems, J.
Nature Methods 19
(10): 1208-1220.
October 2022
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74
(6): 1039-1046.
15 March 2022
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., Raabe, J., Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., Monin, M.B., Hoffmeister, C., Schlabe, S., De Domenico, E., Reusch, N., Händler, K., Reynolds, G., Blüthgen, N., Hack, G., Finnemann, C., Nischalke, H.D., Strassburg, C.P., Stephenson, E., Su, Y., Gardner, L., Yuan, D., Chen, D., Goldman, J., Rosenstiel, P., Schmidt, S.V., Latz, E., Hrusovsky, K., Ball, A.J., Johnson, J.M., Koenig, P.A., Schmidt, F.I., Haniffa, M., Heath, J.R., Kümmerer, B.M., Keitel, V., Jensen, B., Stubbemann, P., Kurth, F., Sander, L.E., Sawitzki, B., Aschenbrenner, A.C., Schultze, J.L. and Nattermann, J.
Immunity 54
(11): 2650-2669.
9 November 2021
NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport.
Moriel, N., Senel, E., Friedman, N., Rajewsky, N., Karaiskos, N. and Nitzan, M.
Nature Protocols 16
(9): 4177-4200.
September 2021
Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S., Schultze, H., Shastry, K.L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N.A., Ktena, S., Tran, F., Bitzer, M., Ossowski, S., Casadei, N., Herr, C., Petersheim, D., Behrends, U., Kern, F., Fehlmann, T., Schommers, P., Lehmann, C., Augustin, M., Rybniker, J., Altmüller, J., Mishra, N., Bernardes, J.P., Krämer, B., Bonaguro, L., Schulte-Schrepping, J., De Domenico, E., Siever, C., Kraut, M., Desai, M., Monnet, B., Saridaki, M., Siegel, C.M., Drews, A., Nuesch-Germano, M., Theis, H., Heyckendorf, J., Schreiber, S., Kim-Hellmuth, S., Nattermann, J., Skowasch, D., Kurth, I., Keller, A., Bals, R., Nürnberg, P., Rieß, O., Rosenstiel, P., Netea, M.G., Theis, F., Mukherjee, S., Backes, M., Aschenbrenner, A.C., Ulas, T., Breteler, M.M.B., Giamarellos-Bourboulis, E.J., Kox, M., Becker, M., Cheran, S., Woodacre, M.S., Goh, E.L. and Schultze, J.L.
Nature 594
(7862): 265-270.
10 June 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C., Karaiskos, N., Boltengagen, A., Walentin, K., Redo, K., Himmerkus, N., Bleich, M., Potter, S.S., Potter, A.S., Eckardt, K.U., Kocks, C., Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32
(2): 291-306.
February 2021
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., Baßler, K., Saridaki, M., Knoll, R., Pecht, T., Kapellos, T.S., Doulou, S., Kröger, C., Herbert, M., Holsten, L., Horne, A., Gemünd, I.D., Rovina, N., Agrawal, S., Dahm, K., van Uelft, M., Drews, A., Lenkeit, L., Bruse, N., Gerretsen, J., Gierlich, J., Becker, M., Händler, K., Kraut, M., Theis, H., Mengiste, S., Domenico, E., Schulte-Schrepping, J., Seep, L., Raabe, J., Hoffmeister, C., ToVinh, M., Keitel, V., Rieke, G., Talevi, V., Skowasch, D., Aziz, N.A., Pickkers, P., van de Veerdonk, F.L., Netea, M.G., Schultze, J.L., Kox, M., Breteler, M.M.B., Nattermann, J., Koutsoukou, A., Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13
(1): 7.
13 January 2021
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P., Mishra, N., Tran, F., Bahmer, T., Best, L., Blase, J.I., Bordoni, D., Franzenburg, J., Geisen, U., Josephs-Spaulding, J., Köhler, P., Künstner, A., Rosati, E., Aschenbrenner, A.C., Bacher, P., Baran, N., Boysen, T., Brandt, B., Bruse, N., Dörr, J., Dräger, A., Elke, G., Ellinghaus, D., Fischer, J., Forster, M., Franke, A., Franzenburg, S., Frey, N., Friedrichs, A., Fuß, J., Glück, A., Hamm, J., Hinrichsen, F., Hoeppner, M.P., Imm, S., Junker, R., Kaiser, S., Kan, Y.H., Knoll, R., Lange, C., Laue, G., Lier, C., Lindner, M., Marinos, G., Markewitz, R., Nattermann, J., Noth, R., Pickkers, P., Rabe, K.F., Renz, A., Röcken, C., Rupp, J., Schaffarzyk, A., Scheffold, A., Schulte-Schrepping, J., Schunk, D., Skowasch, D., Ulas, T., Wandinger, K.P., Wittig, M., Zimmermann, J., Busch, H., Hoyer, B.F., Kaleta, C., Heyckendorf, J., Kox, M., Rybniker, J., Schreiber, S., Schultze, J.L. and Rosenstiel, P.
Immunity 53
(6): 1296-1314.
15 December 2020
LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X.M., Figlerowicz, M., Gasser, S.M., Hubner, N., Kjems, J., Knoblich, J.A., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J.C., Marioni, J., Marti-Renom, M.A., Netea, M.G., Nickel, D., Nollmann, M., Novak, H.R., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J.L., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F.J., Torres-Padilla, M.E., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M. and Voet, T.
Nature 587
(7834): 377-386.
19 November 2020
The transcriptome dynamics of single cells during the cell cycle.
Schwabe, D., Formichetti, S., Junker, J.P., Falcke, M. and Rajewsky, N.
Molecular Systems Biology 16
(11): e9946.
1 November 2020
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Ho-Xuan, H., Glažar, P., Latini, C., Heizler, K., Haase, J., Hett, R., Anders, M., Weichmann, F., Bruckmann, A., Van den Berg, D., Hüttelmaier, S., Rajewsky, N., Hackl, C. and Meister, G.
Nucleic Acids Research 48
(18): 10368-10382.
9 October 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11
(1): 991.
20 February 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
Gene expression cartography.
Nitzan, M., Karaiskos, N., Friedman, N. and Rajewsky, N.
Nature 576
(7785): 132-137.
5 December 2019
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E., Franke, V., Menegatti, J., Kocks, C., Boltengagen, A., Praktiknjo, S., Walch-Rückheim, B., Bosse, J., Rajewsky, N., Grässer, F., Akalin, A. and Landthaler, M.
Nature Communications 10
(1): 4878.
25 October 2019
Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K., Imami, K. and Rajewsky, N.
Nature Communications 10
(1): 4205.
16 September 2019
FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
Legnini, I., Alles, J., Karaiskos, N., Ayoub, S. and Rajewsky, N.
Nature Methods 16
(9): 879-886.
September 2019
The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178
(1): 242-260.
27 June 2019
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.
Wolf, F.A., Hamey, F.K., Plass, M., Solana, J., Dahlin, J.S., Göttgens, B., Rajewsky, N., Simon, L. and Theis, F.J.
Genome Biology 20
(1): 59.
19 March 2019
BCR-dependent lineage plasticity in mature B cells.
Graf, R., Seagal, J., Otipoby, K.L., Lam, K.P., Ayoub, S., Zhang, B., Sander, S., Chu, V.T. and Rajewsky, K.
Science 363
(6428): 748-753.
15 February 2019
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M., Solana, J., Wolf, F.A., Ayoub, S., Misios, A., Glažar, P., Obermayer, B., Theis, F.J., Kocks, C. and Rajewsky, N.
Science 360
(6391): eaaq1723.
25 May 2018
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.
Verduci, L., Ferraiuolo, M., Sacconi, A., Ganci, F., Vitale, J., Colombo, T., Paci, P., Strano, S., Macino, G., Rajewsky, N. and Blandino, G.
Genome Biology 18
(1): 237.
20 December 2017
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E., Menegatti, J., Franke, V., Kocks, C., Boltengagen, A., Hennig, T., Theil, K., Rutkowski, A., Ferrai, C., Baer, L., Kermas, L., Friedel, C., Rajewsky, N., Akalin, A., Dölken, L., Grässer, F. and Landthaler, M.
Genome Biology 18
(1): 209.
31 October 2017
The Drosophila embryo at single-cell transcriptome resolution.
Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., Kocks, C., Rajewsky, N. and Zinzen, R.P.
Science 358
(6360): 194-199.
13 October 2017
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357
(6357): eaam8526.
22 September 2017
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Uyar, B., Yusuf, D., Wurmus, R., Rajewsky, N., Ohler, U. and Akalin, A.
Nucleic Acids Research 45
(10): e91.
2 June 2017
Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.
Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., Sthandier, O., Fatica, A., Santini, T., Andronache, A., Wade, M., Laneve, P., Rajewsky, N. and Bozzoni, I.
Molecular Cell 66
(1): 22-37.e9.
6 April 2017
Translation of circRNAs.
Pamudurti, N.R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., Shenzis, S., Samson, M., Dittmar, G., Landthaler, M., Chekulaeva, M., Rajewsky, N. and Kadener, S.
Molecular Cell 66
(1): 9-21.
6 April 2017
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Stunnenberg, H.G. and Hirst, M.
Cell 167
(7): 1145-1149.
17 November 2016
Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glažar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A.., Ardakani, F.B., Feuerbach, L., Gorka, O., Ebert, P., Müller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Fröhler, S., Felder, B., Gasparoni, N., Imbusch, C.D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A.S., Sieverling, L., Chang, H.D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.R., Rosenstiel, P., Schulz, M.H., Schultze, J.L., Radbruch, A., Walter, J., Hamann, A. and Polansky, J.K.
Immunity 45
(5): 1148-1161.
15 November 2016
The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway.
Hasler, D., Lehmann, G., Murakawa, Y., Klironomos, F., Jakob, L., Grässer, F.A., Rajewsky, N., Landthaler, M. and Meister, G.
Molecular Cell 63
(1): 110-124.
7 July 2016
Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M. and Obermayer, B.
Genome Biology 16
: 179.
14 September 2015
Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed.
Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., Herzog, M., Schreyer, L., Papavasileiou, P., Ivanov, A., Öhman, M., Refojo, D., Kadener, S. and Rajewsky, N.
Molecular Cell 58
(5): 870-885.
4 June 2015
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Schafer, S., Adami, E., Heinig, M., Costa Rodrigues, K.E., Kreuchwig, F., Silhavy, J., van Heesch, S., Simaite, D., Rajewsky, N., Cuppen, E., Pravenec, M., Vingron, M., Cook, S.A. and Hubner, N.
Nature Communications 6
: 7200.
26 May 2015
Competition between target sites of regulators shapes post-transcriptional gene regulation.
Jens, M. and Rajewsky, N.
Nature Reviews Genetics 16
(2): 113-126.
February 2015
Paternal diet defines offspring chromatin state and intergenerational obesity.
Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P.M., Stoeckius, M., Ruf, M., Rajewsky, N., Reuter, G., Iovino, N., Ribeiro, C., Alenius, M., Heyne, S., Vavouri, T. and Pospisilik, J.A.
Cell 159
(6): 1352-1364.
4 December 2014
Mixed messages: re-initiation factors regulate translation of animal mRNAs.
Obermayer, B. and Rajewsky, N.
Cell Research 24
(12): 1383-1384.
December 2014
A variety of dicer substrates in human and C. elegans.
Rybak-Wolf, A., Jens, M., Murakawa, Y., Herzog, M., Landthaler, M. and Rajewsky, N.
Cell 159
(5): 1153-1167.
20 November 2014
circRNA biogenesis competes with pre-mRNA splicing.
Ashwal-Fluss, R., Meyer, M., Pamudurti, N.R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N. and Kadener, S.
Molecular Cell 56
(1): 55-66.
2 October 2014
Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.
Stoeckius, M., Grün, D., Kirchner, M., Ayoub, S., Torti, F., Piano, F., Herzog, M., Selbach, M. and Rajewsky, N.
EMBO Journal 33
(16): 1751-1766.
18 August 2014
Paternal RNA contributions in the Caenorhabditis elegans zygote.
Stoeckius, M., Grün, D. and Rajewsky, N.
EMBO Journal 33
(16): 1740-1750.
18 August 2014
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124
(8): 3419-3430.
1 August 2014
Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.
Grosswendt, S., Filipchyk, A., Manzano, M., Klironomos, F., Schilling, M., Herzog, M., Gottwein, E. and Rajewsky, N.
Molecular Cell 54
(6): 1042-1054.
19 June 2014
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.
Bazzini, A.A., Johnstone, T.G., Christiano, R., Mackowiak, S.D., Obermayer, B., Fleming, E.S., Vejnar, C.E., Lee, M.T., Rajewsky, N., Walther, T.C. and Giraldez, A.J.
EMBO Journal 33
(9): 981-993.
2 May 2014
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495
(7441): 333-338.
21 March 2013
In vivo and transcriptome-wide identification of RNA binding protein target sites.
Jungkamp, A.C., Stoeckius, M., Mecenas, D., Gruen, D., Mastrobuoni, G., Kempa, S. and Rajewsky, N.
Molecular Cell 44
(5): 828-840.
9 December 2011
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Lebedeva, S., Jens, M., Theil, K., Schwanhaeusser, B., Selbach, M., Landthaler, M. and Rajewsky, N.
Molecular Cell 43
(3): 340-352.
5 August 2011
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C., Wang, Y., Gruen, D., Mastrobuoni, G., You, X., Tolle, D., Dodt, M., Mackowiak, S.D., Gogol-Doering, A., Oenal, P., Rybak, A., Ross, E., Alvarado, A.S., Kempa, S., Dieterich, C., Rajewsky, N. and Chen, W.
Genome Research 21
(7): 1193-1200.
July 2011
Integrative analysis of the caenorhabditis elegans genome by the modENCODE project.
Gerstein, M.B., Lu, Z.J., Van Nostrand, E.L., Cheng, C., Arshinoff, B.I., Liu, T., Yip, K.Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, R.K., Feng, X., Leng, J., Vielle, A., Niu, W., Rhrissorrakrai, K., Agarwal, A., Alexander, R.P., Barber, G., Brdlik, C.M., Brennan, J., Brouillet, J.J., Carr, A., Cheung, M.S., Clawson, H., Contrino, S., Dannenberg, L.O., Dernburg, A.F., Desai, A., Dick, L., Dose, A.C., Du, J., Egelhofer, T., Ercan, S., Euskirchen, G., Ewing, B., Feingold, E.A., Gassmann, R., Good, P.J., Green, P., Gullier, F., Gutwein, M., Guyer, M.S., Habegger, L., Han, T., Henikoff, J.G., Henz, S.R., Hinrichs, A., Holster, H., Hyman, T., Iniguez, A.L., Janette, J., Jensen, M., Kato, M., Kent, W.J., Kephart, E., Khivansara, V., Khurana, E., Kim, J.K., Kolasinska-Zwierz, P., Lai, E.C., Latorre, I., Leahey, A., Lewis, S., Lloyd, P., Lochovsky, L., Lowdon, R.F., Lubling, Y., Lyne, R., Maccoss, M., Mackowiak, S.D., Mangone, M., McKay, S., Mecenas, D., Merrihew, G., Miller, D.M., Muroyama, A., Murray, J.I., Ooi, S.L., Pham, H., Phippen, T., Preston, E.A., Rajewsky, N., Raetsch, G., Rosenbaum, H., Rozowsky, J., Rutherford, K., Ruzanov, P., Sarov, M., Sasidharan, R., Sboner, A., Scheid, P., Segal, E., Shin, H., Shou, C., Slack, F.J., Slightam, C., Smith, R., Spencer, W.C., Stinson, E.O., Taing, S., Takasaki, T., Vafeados, D., Voronina, K., Wang, G., Washington, N.L., Whittle, C.M., Wu, B., Yan, K.K., Zeller, G., Zha, Z., Zhong, M., Zhou, X., Ahringer, J., Strome, S., Gunsalus, K.C., Micklem, G., Liu, X.S., Reinke, V., Kim, S.K., Hillier, L.W., Henikoff, S., Piano, F., Snyder, M., Stein, L., Lieb, J.D. and Waterston, R.H.
Science 330
(6012): 1775-1787.
24 December 2010
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B., Haftmann, C., Sgouroudis, E., Kuehl, A.A., Hegazy, A.N., Panse, I., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G.A., Fang, Z., Li, N., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F.M., Baumgrass, R., Bosio, A., Mollenkopf, H.J., Gruen, J., Thiel, A., Chen, W., Hoefer, T., Loddenkemper, C., Loehning, M., Chang, H.D., Rajewsky, N., Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11
(11): 1057-1062.
November 2010
The landscape of C. elegans 3'UTRs.
Mangone, M., Manoharan, A.P., Thierry-Mieg, D., Thierry-Mieg, J., Han, T., Mackowiak, S., Mis, E., Zegar, C., Gutwein, M.R., Khivansara, V., Attie, O., Chen, K., Salehi-Ashtiani, K., Vidal, M., Harkins, T.T., Bouffard, P., Suzuki, Y., Sugano, S., Kohara, Y., Rajewsky, N., Piano, F., Gunsalus, K.C. and Kim, J.K.
Science 329
(5990): 432-435.
23 July 2010
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius, M., Maaskola, J., Colombo, T., Rahn, H.P., Friedlaender, M.R., Li, N., Chen, W., Piano, F. and Rajewsky, N.
Nature Methods 6
(10): 745-751.
October 2009
A human snoRNA with microRNA-like functions.
Ender, C., Krek, A., Friedlaender, M.R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N. and Meister, G.
Molecular Cell 32
(4): 519-528.
21 November 2008
Widespread changes in protein synthesis induced by microRNAs.
Selbach, M., Schwanhaeusser, B., Thierfelder, N., Fang, Z., Khanin, R. and Rajewsky, N.
Nature 455
(7209): 58-63.
4 September 2008
Discovering microRNAs from deep sequencing data using miRDeep.
Friedlaender, M.R., Chen, W., Adamidi, C., Maaskola, J., Einspanier, R., Knespel, S. and Rajewsky, N.
Nature Biotechnology 26
(4): 407-415.
April 2008
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Koralov, S.B., Muljo, S.A., Galler, G.R., Krek, A., Chakraborty, T., Kanellopoulou, C., Jensen, K., Cobb, B.S., Merkenschlager, M., Rajewsky, N. and Rajewsky, K.
Cell 132
(5): 860-874.
7 March 2008
Regulation of the germinal center response by microRNA-155.
Thai, T.H., Calado, D.P., Casola, S., Ansel, K.M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J.L., Schmidt-Supprian, M., Rajewsky, N., Yancopoulos, G., Rao, A. and Rajewsky, K.
Science 316
(5824): 604-608.
27 April 2007
The evolution of gene regulation by transcription factors and microRNAs.
Chen, K. and Rajewsky, N.
Nature Reviews Genetics 8
(2): 93-103.
February 2007
Natural selection on human microRNA binding sites inferred from SNP data.
Chen, K. and Rajewsky, N.
Nature Genetics 38
(12): 1452-1456.
1 December 2006
L(ou)sy miRNA targets?
Rajewsky, N.
Nature Structural & Molecular Biology 13
(9): 754-755.
September 2006
Rathjen, Fritz G.
Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T., Braud, S., Jüttner, R., Voigt, B.C., Paulick, K., Sheean, M.E., Klisch, C., Gueneykaya, D., Rathjen, F.G., Geiger, J.R.P., Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37
(17): e98858.
3 September 2018
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A., Maggio, N., Eller, J., Caliskan, G., Semtner, M., Häussler, U., Jüttner, R., Dugladze, T., Smolinsky, B., Kowalczyk, S., Chronowska, E., Schwarz, G., Rathjen, F.G., Rechavi, G., Haas, C.A., Kulik, A., Gloveli, T., Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124
(2): 696-711.
3 February 2014
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M., Schuster, S., Juettner, R., Parthasarathy, S., Tarabykin, V. and Birchmeier, W.
Genes & Development 26
(15): 1743-1757.
1 August 2012
Silencing neurotransmission with membrane-tethered toxins.
Auer, S., Stuerzebecher, A.S., Juettner, R., Santos-Torres, J., Hanack, C., Frahm, S., Liehl, B. and Ibanez-Tallon, I.
Nature Methods 7
(3): 229-236.
March 2010
The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U., Shi, Y., Wrackmeyer, U., Fischer, R., Chen, C., Schirdewan, A., Juettner, R., Rathjen, F.G., Poller, W., Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205
(10): 2369-2379.
29 September 2008
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J., Lu, Y., Jüttner, R., Smith, E.S.J., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. and Lewin, G.R.
PLoS Biology 6
(1): e13.
29 January 2008
Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Juettner, R., More, M.I., Das, D., Babich, A., Meier, J., Henning, M., Erdmann, B., Mueller, E.C., Otto, A., Grantyn, R. and Rathjen, F.G.
Neuron 46
(2): 233-245.
21 May 2005
cGMP-mediated signaling via cGKIαs required for the guidance and connectivity of sensory axons.
Schmidt, H., Werner, M., Heppenstall, P.A., Henning, M., More, M.I., Kuehbandner, S., Lewin, G.R., Hofmann, F., Feil, R. and Rathjen, F.G.
Journal of Cell Biology 159
(3): 489-498.
11 November 2002
Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation.
More, M.I., Kirsch, F.P. and Rathjen, F.G.
Journal of Cell Biology 154
(1): 187-196.
9 July 2001
Immunoglobulin superfamily receptors: cis-interactions, intracellular adapters and alternative splicing regulate adhesion.
Bruemmendorf, T. and Lemmon, V.
Current Opinion in Cell Biology 13
(5): 611-618.
1 January 2001
Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick.
Perrin, F.E., Rathjen, F.G. and Stoeckli, E.T.
Neuron 30
(3): 707-723.
1 January 2001
Pathological missense mutations of neural cell adhesion molecule L1 affect hemophilic and heterophilic binding activities.
De Angelis, E., MacFarlane, J., Du, J.S., Yeo, G., Hicks, R., Rathjen, F.G., Kenwrick, S. and Bruemmendorf, T.
EMBO Journal 18
: 4744-4753.
1 September 1999
Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP.
Marg, A., Sirim, P., Spaltmann, F., Plagge, A., Kauselmann, G., Buck, F., Rathjen, F.G. and Bruemmendorf, T.
Journal of Cell Biology 145
(4): 865-876.
17 May 1999
Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells.
Volkmer, H., Zacharias, U., Noerenberg, U. and Rathjen, F.G.
Journal of Cell Biology 142
: 1083-1093.
24 August 1998
Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation.
Schumacher, S., Volkmer, H., Buck, F., Otto, A., Tarnok, A., Roth, S. and Rathjen, F.G.
Journal of Cell Biology 136
(4): 895-906.
24 February 1997
Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites.
Volkmer, H., Leuschner, R., Zacharias, U. and Rathjen, F.G.
Journal of Cell Biology 135
(4): 1059-1069.
November 1996
Characterization of functional domains of the tenascin-R (restrictin) polypeptide: cell attachment site, binding with F11 and enhancement of F11 mediated neurite outgrowth by tenascin-R.
Noerenberg, U., Hubert, M., Bruemmendorf, T., Tarnok, A. and Rathjen, F.G.
Journal of Cell Biology 130
(2): 473-484.
July 1995
Rehm, Armin
CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15
: 1383136.
24 June 2024
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13
(1): 7341.
29 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A., Bunse, M., Joedicke, J.J., Blanc, E., Gudipati, V., Moles, M.W., Shiku, H., Beule, D., Huppa, J.B., Höpken, U.E. and Rehm, A.
Molecular Therapy 30
(11): 3358-3378.
2 November 2022
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12
(1): 240.
11 January 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80
(6): 1316-1329.
March 2020
Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5
(6): 351-364.
June 2019
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109
(3): 886-895.
1 February 2007
Reich, Jens
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics.
Sakenova, N., Cacace, E., Orakov, A., Huber, F., Varik, V., Kritikos, G., Michiels, J., Bork, P., Cossart, P., Goemans, C.V. and Typas, A.
Nature Microbiology
2 December 2024
(In Press)
The STRING database in 2025: protein networks with directionality of regulation.
Szklarczyk, D., Nastou, K., Koutrouli, M., Kirsch, R., Mehryary, F., Hachilif, R., Hu, D., Peluso, M.E., Huang, Q., Fang, T., Doncheva, N.T., Pyysalo, S., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research
18 November 2024
(In Press)
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations.
Nishijima, S., Stankevic, E., Aasmets, O., Schmidt, T.S.B., Nagata, N., Keller, M.I., Ferretti, P., Juel, H.B., Fullam, A., Robbani, S.M., Schudoma, C., Hansen, J.K., Holm, L.A., Israelsen, M., Schierwagen, R., Torp, N., Telzerow, A., Hercog, R., Kandels, S., Hazenbrink, D.H.M., Arumugam, M., Bendtsen, F., Brøns, C., Fonvig, C.E., Holm, J.C., Nielsen, T., Pedersen, J.S., Thiele, M.S., Trebicka, J., Org, E., Krag, A., Hansen, T., Kuhn, M. and Bork, P.
Cell
13 November 2024
(In Press)
Emergence of community behaviors in the gut microbiota upon drug treatment.
Garcia-Santamarina, S., Kuhn, M., Devendran, S., Maier, L., Driessen, M., Mateus, A., Mastrorilli, E., Brochado, A.R., Savitski, M.M., Patil, K.R., Zimmermann, M., Bork, P. and Typas, A.
Cell 187
(22): 6346-6357.e20.
31 October 2024
A catalog of small proteins from the global microbiome.
Duan, Y., Santos-Júnior, C.D., Schmidt, T.S., Fullam, A., de Almeida, B.L.S., Zhu, C., Kuhn, M., Zhao, X.M., Bork, P. and Coelho, L.P.
Nature Communications 15
(1): 7563.
31 August 2024
Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts.
Lai, S., Wang, H., Bork, P., Chen, W.H. and Zhao, X.M.
Science Advances 10
(33): eadn3316.
16 August 2024
Review: Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases.
Thiele, M., Villesen, I.., Niu, L., Johansen, S., Sulek, K., Nishijima, S., Van Espen, L., Keller, M., Israelsen, M., Suvitaival, T., de Zawadzki, A., Juel, H.B., Brol, M.J., Stinson, S.E., Huang, Y., Alvarez Silva, M.C., Kuhn, M., Anastasiadou, E., Leeming, D.J., Karsdal, M., Matthijnssens, J., Arumugam, M., Dalgaard, L.T., Legido-Quigley, C., Mann, M., Trebicka, J., Bork, P., Jensen, L.J., Hansen, T. and Krag, A.
Journal of Hepatology 81
(2): 345-359.
August 2024
Discovery of antimicrobial peptides in the global microbiome with machine learning.
Santos-Júnior, C.D., Torres, M.D.T., Duan, Y., Rodríguez Del Río, Á., Schmidt, T.S.B., Chong, H., Fullam, A., Kuhn, M., Zhu, C., Houseman, A., Somborski, J., Vines, A., Zhao, X.M., Bork, P., Huerta-Cepas, J., de la Fuente-Nunez, C. and Coelho, L.P.
Cell 187
(14): 3761-3778.
11 July 2024
Efficient recovery of complete gut viral genomes by combined short- and long-read sequencing.
Chen, J., Sun, C., Dong, Y., Jin, M., Lai, S., Jia, L., Zhao, X., Wang, H., Gao, N.L., Bork, P., Liu, Z., Chen, W.H. and Zhao, X.M.
Advanced Science 11
(13): 2305818.
3 April 2024
High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.
Müller, P., de la Cuesta-Zuluaga, J., Kuhn, M., Baghai Arassi, M., Treis, T., Blasche, S., Zimmermann, M., Bork, P., Patil, K.R., Typas, A., Garcia-Santamarina, S. and Maier, L.
Nature Protocols 19
(3): 668-699.
March 2024
Functional and evolutionary significance of unknown genes from uncultivated taxa.
Rodríguez Del Río, Á., Giner-Lamia, J., Cantalapiedra, C.P., Botas, J., Deng, Z., Hernández-Plaza, A., Munar-Palmer, M., Santamaría-Hernando, S., Rodríguez-Herva, J.J., Ruscheweyh, H.J., Paoli, L., Schmidt, T.S.B., Sunagawa, S., Bork, P., López-Solanilla, E., Coelho, L.P. and Huerta-Cepas, J.
Nature 626
(7998): 377-384.
8 February 2024
SPIRE: a Searchable, Planetary-scale mIcrobiome REsource.
Schmidt, T.S.B., Fullam, A., Ferretti, P., Orakov, A., Maistrenko, O.M., Ruscheweyh, H.J., Letunic, I., Duan, Y., Van Rossum, T., Sunagawa, S., Mende, D.R., Finn, R.D., Kuhn, M., Pedro Coelho, L. and Bork, P.
Nucleic Acids Research 52
(D1): D777-D783.
5 January 2024
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S.K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J.E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M.T., Hoyles, L., Alves, R., Helft, G., Isnard, R., Køber, L., Coelho, L.P., Rouault, C., Gauguier, D., Gøtze, J.P., Prifti, E., Froguel, P., Zucker, J.D., Bäckhed, F., Vestergaard, H., Hansen, T., Oppert, J.M., Blüher, M., Nielsen, J., Raes, J., Bork, P., Yaqoob, M.M., Stumvoll, M., Pedersen, O., Ehrlich, S.D., Clément, K. and Dumas, M.E.
Nature Communications 14
(1): 5843.
20 September 2023
Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases.
Sun, C., Chen, J., Jin, M., Zhao, X., Li, Y., Dong, Y., Gao, N., Liu, Z., Bork, P., Zhao, X.M. and Chen, W.H.
Advanced Science 10
(25): 2302159.
5 September 2023
Enterotypes of the human gut mycobiome.
Lai, S., Yan, Y., Pu, Y., Lin, S., Qiu, J.G., Jiang, B.H., Keller, M.I., Wang, M., Bork, P., Chen, W.H., Zheng, Y. and Zhao, X.M.
Microbiome 11
(1): 179.
11 August 2023
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
Kennedy, K.M., de Goffau, M.C., Perez-Muñoz, M.E., Arrieta, M.C., Bäckhed, F., Bork, P., Braun, T., Bushman, F.D., Dore, J., de Vos, W.M., Earl, A.M., Eisen, J.A., Elovitz, M.A., Ganal-Vonarburg, S.C., Gänzle, M.G., Garrett, W.S., Hall, L.J., Hornef, M.W., Huttenhower, C., Konnikova, L., Lebeer, S., Macpherson, A.J., Massey, R.C., McHardy, A.C., Koren, O., Lawley, T.D., Ley, R.E., O'Mahony, L., O'Toole, P.W., Pamer, E.G., Parkhill, J., Raes, J., Rattei, T., Salonen, A., Segal, E., Segata, N., Shanahan, F., Sloboda, D.M., Smith, G.C.S., Sokol, H., Spector, T.D., Surette, M.G., Tannock, G.W., Walker, A.W., Yassour, M. and Walter, J.
Nature 613
(7945): 639-649.
26 January 2023
proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes.
Fullam, A., Letunic, I., Schmidt, T.S.B., Ducarmon, Q.R., Karcher, N., Khedkar, S., Kuhn, M., Larralde, M., Maistrenko, O.M., Malfertheiner, L., Milanese, A., Rodrigues, J.F.M., Sanchis-López, C., Schudoma, C., Szklarczyk, D., Sunagawa, S., Zeller, G., Huerta-Cepas, J., von Mering, C., Bork, P. and Mende, D.R.
Nucleic Acids Research 51
(D1): D760-D766.
6 January 2023
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.
Szklarczyk, D., Kirsch, R., Koutrouli, M., Nastou, K., Mehryary, F., Hachilif, R., Gable, A.L., Fang, T., Doncheva, N.T., Pyysalo, S., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 51
(D1): D638-D646.
6 January 2023
Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by integrated multi-omic analyses.
Kunath, B.J., Hickl, O., Queirós, P., Martin-Gallausiaux, C., Lebrun, L.A., Halder, R., Laczny, C.C., Schmidt, T.S.B., Hayward, M.R., Becher, D., Heintz-Buschart, A., de Beaufort, C., Bork, P., May, P. and Wilmes, P.
Microbiome 10
(1): 243.
28 December 2022
Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments.
Ruscheweyh, H.J., Milanese, A., Paoli, L., Karcher, N., Clayssen, Q., Keller, M.I., Wirbel, J., Bork, P., Mende, D.R., Zeller, G. and Sunagawa, S.
Microbiome 10
(1): 212.
5 December 2022
Dissecting the intracellular pancreatic tumor microbiome at single-cell level.
Schmidt, T.S.B. and Bork, P.
Cancer Cell 40
(10): 1083-1085.
10 October 2022
Drivers and determinants of strain dynamics following fecal microbiota transplantation.
Schmidt, T.S.B., Li, S.S., Maistrenko, O.M., Akanni, W., Coelho, L.P., Dolai, S., Fullam, A., Glazek, A.M., Hercog, R., Herrema, H., Jung, F., Kandels, S., Orakov, A., Thielemann, R., von Stetten, M., Van Rossum, T., Benes, V., Borody, T.J., de Vos, W.M., Ponsioen, C.Y., Nieuwdorp, M. and Bork, P.
Nature Medicine 28
(9): 1902-1912.
September 2022
Biosynthetic potential of the global ocean microbiome.
Paoli, L., Ruscheweyh, H.J., Forneris, C.C., Hubrich, F., Kautsar, S., Bhushan, A., Lotti, A., Clayssen, Q., Salazar, G., Milanese, A., Carlström, C.I., Papadopoulou, C., Gehrig, D., Karasikov, M., Mustafa, H., Larralde, M., Carroll, L.M., Sánchez, P., Zayed, A.A., Cronin, D.R., Acinas, S.G., Bork, P., Bowler, C., Delmont, T.O., Gasol, J.M., Gossert, A.D., Kahles, A., Sullivan, M.B., Wincker, P., Zeller, G., Robinson, S.L., Piel, J. and Sunagawa, S.
Nature 607
(7917): 111-118.
7 July 2022
A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal, E., Schmidt, T.S.B., Molina-Montes, E., Rodríguez-Perales, S., Wirbel, J., Maistrenko, O.M., Akanni, W.A., Alashkar Alhamwe, B., Alves, R.J., Carrato, A., Erasmus, H.P., Estudillo, L., Finkelmeier, F., Fullam, A., Glazek, A.M., Gómez-Rubio, P., Hercog, R., Jung, F., Kandels, S., Kersting, S., Langheinrich, M., Márquez, M., Molero, X., Orakov, A., Van Rossum, T., Torres-Ruiz, R., Telzerow, A., Zych, K., Benes, V., Zeller, G., Trebicka, J., Real, F.X., Malats, N. and Bork, P.
Gut 71
(7): 1359-1372.
7 June 2022
Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S., Smyshlyaev, G., Letunic, I., Maistrenko, O.M., Coelho, L.P., Orakov, A., Forslund, S.K., Hildebrand, F., Luetge, M., Schmidt, T.S.B., Barabas, O. and Bork, P.
Nucleic Acids Research 50
(6): 3155-3168.
8 April 2022
Towards the biogeography of prokaryotic genes.
Coelho, L.P., Alves, R., Del Río, Á.R., Myers, P.N., Cantalapiedra, C.P., Giner-Lamia, J., Schmidt, T.S., Mende, D.R., Orakov, A., Letunic, I., Hildebrand, F., Van Rossum, T., Forslund, S.K., Khedkar, S., Maistrenko, O.M., Pan, S., Jia, L., Ferretti, P., Sunagawa, S., Zhao, X.M., Nielsen, H.B., Huerta-Cepas, J. and Bork, P.
Nature 601
(7892): 252-256.
13 January 2022
Compendium of 530 metagenome-assembled bacterial and archaeal genomes from the polar Arctic Ocean.
Royo-Llonch, M., Sánchez, P., Ruiz-González, C., Salazar, G., Pedrós-Alió, C., Sebastián, M., Labadie, K., Paoli, L., M. Ibarbalz, F., Zinger, L., Churcheward, B., Chaffron, S., Eveillard, D., Karsenti, E., Sunagawa, S., Wincker, P., Karp-Boss, L., Bowler, C. and Acinas, S.G.
Nature Microbiology 6
(12): 1561-1574.
December 2021
Unravelling the collateral damage of antibiotics on gut bacteria.
Maier, L., Goemans, C.V., Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., Garcia-Santamarina, S., Cacace, E., Zhang, B., Gekeler, C., Banerjee, T., Anderson, E.E., Milanese, A., Löber, U., Forslund, S.K., Patil, K.R., Zimmermann, M., Stecher, B., Zeller, G., Bork, P. and Typas, A.
Nature 599
: 120-124.
4 November 2021
Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
Gebert, J., Gelincik, O., Oezcan-Wahlbrink, M., Marshall, J.D., Hernandez-Sanchez, A., Urban, K., Long, M., Cortes, E., Tosti, E., Katzenmaier, E.M., Song, Y., Elsaadi, A., Deng, N., Vilar, E., Fuchs, V., Nelius, N., Yuan, Y.P., Ahadova, A., Sei, S., Shoemaker, R.H., Umar, A., Wei, L., Liu, S., Bork, P., Edelmann, W., von Knebel Doeberitz, M., Lipkin, S.M. and Kloor, M.
Gastroenterology 161
(4): 288-1302.e13.
October 2021
Bioaccumulation of therapeutic drugs by human gut bacteria.
Klünemann, M., Andrejev, S., Blasche, S., Mateus, A., Phapale, P., Devendran, S., Vappiani, J., Simon, B., Scott, T.A., Kafkia, E., Konstantinidis, D., Zirngibl, K., Mastrorilli, E., Banzhaf, M., Mackmull, M.T., Hövelmann, F., Nesme, L., Brochado, A.R., Maier, L., Bock, T., Periwal, V., Kumar, M., Kim, Y., Tramontano, M., Schultz, C., Beck, M., Hennig, J., Zimmermann, M., Sévin, D.C., Cabreiro, F., Savitski, M.M., Bork, P., Typas, A. and Patil, K.R.
Nature 597
: 533-538.
23 September 2021
Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F., Gossmann, T.I., Frioux, C., Özkurt, E., Myers, P.N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H.B. and Bork, P.
Cell Host & Microbe 29
(7): 1167-1176.
14 June 2021
GUNC: detection of chimerism and contamination in prokaryotic genomes.
Orakov, A., Fullam, A., Coelho, L.P., Khedkar, S., Szklarczyk, D., Mende, D.R., Schmidt, T.S.B. and Bork, P.
Genome Biology 22
(1): 178.
13 June 2021
Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.
Wirbel, J., Zych, K., Essex, M., Karcher, N., Kartal, E., Salazar, G., Bork, P., Sunagawa, S. and Zeller, G.
Genome Biology 22
(1): 93.
30 March 2021
OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.
Gurumayum, S., Jiang, P., Hao, X., Campos, T.L., Young, N.D., Korhonen, P.K., Gasser, R.B., Bork, P., Zhao, X.M., He, L.J. and Chen, W.H.
Nucleic Acids Research 49
(D1): D998-D1003.
8 January 2021
SMART: recent updates, new developments and status in 2020.
Letunic, I., Khedkar, S. and Bork, P.
Nucleic Acids Research 49
(D1): D458-D460.
8 January 2021
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.
Szklarczyk, D., Gable, A.L., Nastou, K.C., Lyon, D., Kirsch, R., Pyysalo, S., Doncheva, N.T., Legeay, M., Fang, T., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 49
(D): D605-D612.
8 January 2021
Diversity within species: interpreting strains in microbiomes.
Van Rossum, T., Ferretti, P., Maistrenko, O.M. and Bork, P.
Nature Reviews Microbiology 18
: 491-506.
September 2020
Tara Oceans: towards global ocean ecosystems biology.
Sunagawa, S., Acinas, S.G., Bork, P., Bowler, C., Eveillard, D., Gorsky, G., Guidi, L., Iudicone, D., Karsenti, E., Lombard, F., Ogata, H., Pesant, S., Sullivan, M.B., Wincker, P. and de Vargas, C.
Nature Reviews Microbiology 18
(8): 428-445.
August 2020
Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.
Maistrenko, O.M., Mende, D.R., Luetge, M., Hildebrand, F., Schmidt, T.S.B., Li, S.S., Rodrigues, J.F.M., von Mering, C., Pedro Coelho, L., Huerta-Cepas, J., Sunagawa, S. and Bork, P.
ISME Journal 14
(5): 1247-1259.
May 2020
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.
Mende, D.R., Letunic, I., Maistrenko, O.M., Schmidt, T.S.B., Milanese, A., Paoli, L., Hernández-Plaza, A., Orakov, A.N., Forslund, S.K., Sunagawa, S., Zeller, G., Huerta-Cepas, J., Coelho, L.P. and Bork, P.
Nucleic Acids Research 48
(D1): D621-D625.
8 January 2020
Gene expression changes and community turnover differentially shape the global ocean metatranscriptome.
Salazar, G., Paoli, L., Alberti, A., Huerta-Cepas, J., Ruscheweyh, H.J., Cuenca, M., Field, C.M., Coelho, L.P., Cruaud, C., Engelen, S., Gregory, A.C., Labadie, K., Marec, C., Pelletier, E., Royo-Llonch, M., Roux, S., Sánchez, P., Uehara, H., Zayed, A.A., Zeller, G., Carmichael, M., Dimier, C., Ferland, J., Kandels, S., Picheral, M., Pisarev, S., Poulain, J., Acinas, S.G., Babin, M., Bork, P., Bowler, C., de Vargas, C., Guidi, L., Hingamp, P., Iudicone, D., Karp-Boss, L., Karsenti, E., Ogata, H., Pesant, S., Speich, S., Sullivan, M.B., Wincker, P. and Sunagawa, S.
Cell 179
(5): 1068-1083.
14 November 2019
Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
Tito, R.Y., Chaffron, S., Caenepeel, C., Lima-Mendez, G., Wang, J., Vieira-Silva, S., Falony, G., Hildebrand, F., Darzi, Y., Rymenans, L., Verspecht, C., Bork, P., Vermeire, S., Joossens, M. and Raes, J.
Gut 68
(7): 1180-1189.
7 June 2019
NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language.
Coelho, L.P., Alves, R., Monteiro, P., Huerta-Cepas, J., Freitas, A.T. and Bork, P.
Microbiome 7
(1): 84.
3 June 2019
Disentangling genetic and environmental effects on the proteotypes of individuals.
Romanov, N., Kuhn, M., Aebersold, R., Ori, A., Beck, M. and Bork, P.
Cell 177
(5): 1308-1318.
16 May 2019
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
Thomas, A.M., Manghi, P., Asnicar, F., Pasolli, E., Armanini, F., Zolfo, M., Beghini, F., Manara, S., Karcher, N., Pozzi, C., Gandini, S., Serrano, D., Tarallo, S., Francavilla, A., Gallo, G., Trompetto, M., Ferrero, G., Mizutani, S., Shiroma, H., Shiba, S., Shibata, T., Yachida, S., Yamada, T., Wirbel, J., Schrotz-King, P., Ulrich, C.M., Brenner, H., Arumugam, M., Bork, P., Zeller, G., Cordero, F., Dias-Neto, E., Setubal, J.C., Tett, A., Pardini, B., Rescigno, M., Waldron, L., Naccarati, A. and Segata, N.
Nature Medicine 25
(4): 667-678.
April 2019
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Wirbel, J., Pyl, P.T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J.S., Voigt, A.Y., Palleja, A., Ponnudurai, R., Sunagawa, S., Coelho, L.P., Schrotz-King, P., Vogtmann, E., Habermann, N., Niméus, E., Thomas, A.M., Manghi, P., Gandini, S., Serrano, D., Mizutani, S., Shiroma, H., Shiba, S., Shibata, T., Yachida, S., Yamada, T., Waldron, L., Naccarati, A., Segata, N., Sinha, R., Ulrich, C.M., Brenner, H., Arumugam, M., Bork, P. and Zeller, G.
Nature Medicine 25
(4): 679-689.
April 2019
Microbial abundance, activity and population genomic profiling with mOTUs2.
Milanese, A., Mende, D.R., Paoli, L., Salazar, G., Ruscheweyh, H.J., Cuenca, M., Hingamp, P., Alves, R., Costea, P.I., Coelho, L.P., Schmidt, T.S.B., Almeida, A., Mitchell, A.L., Finn, R.D., Huerta-Cepas, J., Bork, P., Zeller, G. and Sunagawa, S.
Nature Communications 10
(1): 1014.
4 March 2019
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Huerta-Cepas, J., Szklarczyk, D., Heller, D., Hernández-Plaza, A., Forslund, S.K., Cook, H., Mende, D.R., Letunic, I., Rattei, T., Jensen, L.J., von Mering, C. and Bork, P.
Nucleic Acids Research 47
(D1): D309-D314.
8 January 2019
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
Szklarczyk, D., Gable, A.L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N.T., Morris, J.H., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 47
(D1): D607-D613.
8 January 2019
Recovery of gut microbiota of healthy adults following antibiotic exposure.
Palleja, A., Mikkelsen, K.H., Forslund, S.K., Kashani, A., Allin, K.H., Nielsen, T., Hansen, T.H., Liang, S., Feng, Q., Zhang, C., Pyl, P.T., Coelho, L.P., Yang, H., Wang, J., Typas, A., Nielsen, M.F., Nielsen, H.B., Bork, P., Wang, J., Vilsbøll, T., Hansen, T., Knop, F.K., Arumugam, M. and Pedersen, O.
Nature Microbiology 3
: 1255-1265.
November 2018
Structure and function of the global topsoil microbiome.
Bahram, M., Hildebrand, F., Forslund, S.K., Anderson, J.L., Soudzilovskaia, N.A., Bodegom, P.M., Bengtsson-Palme, J., Anslan, S., Coelho, L.P., Harend, H., Huerta-Cepas, J., Medema, M.H., Maltz, M.R., Mundra, S., Olsson, P.A., Pent, M., Põlme, S., Sunagawa, S., Ryberg, M., Tedersoo, L. and Bork, P.
Nature 560
(7717): 233-237.
9 August 2018
iPath3.0: interactive pathways explorer v3.
Darzi, Y., Letunic, I., Bork, P. and Yamada, T.
Nucleic Acids Research 46
(W1): W510-W513.
2 July 2018
Species-specific activity of antibacterial drug combinations.
Brochado, A.R., Telzerow, A., Bobonis, J., Banzhaf, M., Mateus, A., Selkrig, J., Huth, E., Bassler, S., Zamarreño Beas, J., Zietek, M., Ng, N., Foerster, S., Ezraty, B., Py, B., Barras, F., Savitski, M.M., Bork, P., Göttig, S. and Typas, A.
Nature 559
(7713): 259-263.
July 2018
Pervasive protein thermal stability variation during the cell cycle.
Becher, I., Andrés-Pons, A., Romanov, N., Stein, F., Schramm, M., Baudin, F., Helm, D., Kurzawa, N., Mateus, A., Mackmull, M.T., Typas, A., Müller, C.W., Bork, P., Beck, M. and Savitski, M.M.
Cell 173
(6): 1495-1507.
31 May 2018
Similarity of the dog and human gut microbiomes in gene content and response to diet.
Coelho, L.P., Kultima, J.R., Costea, P.I., Fournier, C., Pan, Y., Czarnecki-Maulden, G., Hayward, M.R., Forslund, S.K., Schmidt, T.S.B., Descombes, P., Jackson, J.R., Li, Q. and Bork, P.
Microbiome 6
(1): 72.
19 April 2018
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.
Tramontano, M., Andrejev, S., Pruteanu, M., Klünemann, M., Kuhn, M., Galardini, M., Jouhten, P., Zelezniak, A., Zeller, G., Bork, P., Typas, A. and Patil, K.R.
Nature Microbiology 3
(3): 514-522.
April 2018
Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E.E., Brochado, A.R., Fernandez, K.C., Dose, H., Mori, H., Patil, K.R., Bork, P. and Typas, A.
Nature 555
(7698): 623-628.
29 March 2018
Transposase-DNA complex structures reveal mechanisms for conjugative transposition of antibiotic resistance.
Rubio-Cosials, A., Schulz, E.C., Lambertsen, L., Smyshlyaev, G., Rojas-Cordova, C., Forslund, K., Karaca, E., Bebel, A., Bork, P. and Barabas, O.
Cell 173
(1): 208-220.
22 March 2018
The human gut microbiome: from association to modulation.
Schmidt, T.S.B., Raes, J. and Bork, P.
Cell 172
(6): 1198-1215.
8 March 2018
A global ocean atlas of eukaryotic genes.
Carradec, Q., Pelletier, E., Da Silva, C., Alberti, A., Seeleuthner, Y., Blanc-Mathieu, R., Lima-Mendez, G., Rocha, F., Tirichine, L., Labadie, K., Kirilovsky, A., Bertrand, A., Engelen, S., Madoui, M.A., Méheust, R., Poulain, J., Romac, S., Richter, D.J., Yoshikawa, G., Dimier, C., Kandels-Lewis, S., Picheral, M., Searson, S., Jaillon, O., Aury, J.M., Karsenti, E., Sullivan, M.B., Sunagawa, S., Bork, P., Not, F., Hingamp, P., Raes, J., Guidi, L., Ogata, H., De Vargas, C., Iudicone, D., Bowler, C. and Wincker, P.
Nature Communications 9
(1): 373.
25 January 2018
MVP: a microbe-phage interaction database.
Gao, N.L., Zhang, C., Zhang, Z., Hu, S., Lercher, M.J., Zhao, X.M., Bork, P., Liu, Z. and Chen, W.H.
Nucleic Acids Research 46
(D1): D700-D707.
4 January 2018
Enterotypes in the landscape of gut microbial community composition.
Costea, P.I., Hildebrand, F., Manimozhiyan, A., Baeckhed, F., Blaser, M.J., Bushman, F.D., de Vos, W.M., Ehrlich, S.D., Fraser, C.M., Hattori, M., Huttenhower, C., Jeffery, I.B., Knights, D., Lewis, J.D., Ley, R.E., Ochman, H., O'Toole, P.W., Quince, C., Relman, D.A., Shanahan, F., Sunagawa, S., Wang, J., Weinstock, G.M., Wu, G.D., Zeller, G., Zhao, L., Raes, J., Knight, R. and Bork, P.
Nature Microbiology 3
(1): 8-16.
January 2018
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N., Matus, M.G., Kearney, S.M., Olesen, S.W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F.H., Tsvetkov, D., Klug, L., Costea, P.I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., Neubert, P., Frätzer, C., Krannich, A., Gollasch, M., Grohme, D.A., Côrte-Real, B.F., Gerlach, R.G., Basic, M., Typas, A., Wu, C., Titze, J.M., Jantsch, J., Boschmann, M., Dechend, R., Kleinewietfeld, M., Kempa, S., Bork, P., Linker, R.A., Alm, E.J. and Müller, D.N.
Nature 551
(7682): 585-589.
30 November 2017
Towards standards for human fecal sample processing in metagenomic studies.
Costea, P.I., Zeller, G., Sunagawa, S., Pelletier, E., Alberti, A., Levenez, F., Tramontano, M., Driessen, M., Hercog, R., Jung, F.E., Kultima, J.R., Hayward, M.R., Coelho, L.P., Allen-Vercoe, E., Bertrand, L., Blaut, M., Brown, J.R.M., Carton, T., Cools-Portier, S., Daigneault, M., Derrien, M., Druesne, A., de Vos, W.M., Finlay, B.B., Flint, H.J., Guarner, F., Hattori, M., Heilig, H., Luna, R.A., van Hylckama Vlieg, J., Junick, J., Klymiuk, I., Langella, P., Le Chatelier, Z., Mai, V., Manichanh, C., Martin, J.C., Mery, C., Morita, H., O'Toole, P.W., Orvain, C., Patil, K.R., Penders, J., Persson, S., Pons, N., Popova, M., Salonen, A., Saulnier, D., Scott, K.P., Singh, B., Slezak, K., Veiga, P., Versalovic, J., Zhao, L., Zoetendal, E.G., Ehrlich, S.D., Dore, J. and Bork, P.
Nature Biotechnology 35
(11): 1069-1076.
November 2017
Fast genome-wide functional annotation through orthology assignment by eggNOG-mapper.
Huerta-Cepas, J., Forslund, K., Coelho, L.P., Szklarczyk, D., Jensen, L.J., von Mering, C. and Bork, P.
Molecular Biology and Evolution 34
(8): 2115-2122.
1 August 2017
OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines.
Chen, W.H., Lu, G., Chen, X., Zhao, X.M. and Bork, P.
Nucleic Acids Research 45
(D1): D940-D944.
4 January 2017
proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
Mende, D.R., Letunic, I., Huerta-Cepas, J., Li, S.S., Forslund, K., Sunagawa, S. and Bork, P.
Nucleic Acids Research 45
(D1): D529-D534.
4 January 2017
The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Szklarczyk, D., Morris, J.H., Cook, H., Kuhn, M., Wyder, S., Simonovic, M., Santos, A., Doncheva, N.T., Roth, A., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 45
(D1): D362-D368.
4 January 2017
Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
Roux, S., Brum, J.R., Dutilh, B.E., Sunagawa, S., Duhaime, M.B., Loy, A., Poulos, B.T., Solonenko, N., Lara, E., Poulain, J., Pesant, S., Kandels-Lewis, S., Dimier, C., Picheral, M., Searson, S., Cruaud, C., Alberti, A., Duarte, C.M., Gasol, J.M., Vaque, D., Bork, P., Acinas, S.G., Wincker, P. and Sullivan, M.B.
Nature 537
(7622): 689-693.
29 September 2016
Human gut microbes impact host serum metabolome and insulin sensitivity.
Pedersen, H.K., Gudmundsdottir, V., Nielsen, H.B., Hyotylainen, T., Nielsen, T., Jensen, B.A.H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D.R., Pöhö, P., Hellgren, L.I., Arumugam, M., Sunagawa, S., Vieira-Silva, S., Jørgensen, T., Holm, J.B., Trošt, K., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Oresic, M., Ehrlich, S.D. and Pedersen, O.
Nature 535
(7612): 376-381.
21 July 2016
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.
Letunic, I. and Bork, P.
Nucleic Acids Research 44
(W1): W242-W245.
8 July 2016
Standardized benchmarking in the quest for orthologs.
Altenhoff, A.M., Boeckmann, B., Capella-Gutierrez, S., Dalquen, D.A., DeLuca, T., Forslund, K., Huerta-Cepas, J., Linard, B., Pereira, C., Pryszcz, L.P., Schreiber, F., da Silva, A.S., Szklarczyk, D., Train, C.M., Bork, P., Lecompte, O., von Mering, C., Xenarios, I., Sjölander, K., Jensen, L.J., Martin, M.J., Muffato, M., Gabaldón, T., Lewis, S.E., Thomas, P.D., Sonnhammer, E. and Dessimoz, C.
Nature Methods 13
(5): 425-430.
May 2016
Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li, S.S., Zhu, A., Benes, V., Costea, P.I., Hercog, R., Hildebrand, F., Huerta-Cepas, J., Nieuwdorp, M., Salojaervi, J., Voigt, A.Y., Zeller, G., Sunagawa, S., de Vos, W.M. and Bork, P.
Science 352
(6285): 586-589.
29 April 2016
Plankton networks driving carbon export in the oligotrophic ocean.
Guidi, L., Chaffron, S., Bittner, L., Eveillard, D., Larhlimi, A., Roux, S., Darzi, Y., Audic, S., Berline, L., Brum, J., Coelho, L.P., Espinoza, J.C.I., Malviya, S., Sunagawa, S., Dimier, C., Kandels-Lewis, S., Picheral, M., Poulain, J., Searson, S., Stemmann, L., Not, F., Hingamp, P., Speich, S., Follows, M., Karp-Boss, L., Boss, E., Ogata, H., Pesant, S., Weissenbach, J., Wincker, P., Acinas, S.G., Bork, P., de Vargas, C., Iudicone, D., Sullivan, M.B., Raes, J., Karsenti, E., Bowler, C. and Gorsky, G.
Nature 532
(7600): 465-470.
28 April 2016
Energy efficiency trade-offs drive nucleotide usage in transcribed regions.
Chen, W.H., Lu, G., Bork, P., Hu, S. and Lercher, M.J.
Nature Communications 7
: 11334.
21 April 2016
Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton.
Cornejo-Castillo, F.M., Cabello, A.M., Salazar, G., Sanchez-Baracaldo, P., Lima-Mendez, G., Hingamp, P., Alberti, A., Sunagawa, S., Bork, P., de Vargas, C., Raes, J., Bowler, C., Wincker, P., Zehr, J.P., Gasol, J.M., Massana, R. and Acinas, S.G.
Nature Communications 7
: 11071.
22 March 2016
Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori, A., Iskar, M., Buczak, K., Kastritis, P., Parca, L., Andres-Pons, A., Singer, S., Bork, P. and Beck, M.
Genome Biology 17
(1): 47.
14 March 2016
Integration of multi-omics data of a genome-reduced bacterium: prevalence of post-transcriptional regulation and its correlation with protein abundances.
Chen, W.H., van Noort, V., Lluch-Senar, M., Hennrich, M.L., Wodke, J.A.H., Yus, E., Alibes, A., Roma, G., Mende, D.R., Pesavento, C., Typas, A., Gavin, A.C., Serrano, L. and Bork, P.
Nucleic Acids Research 44
(3): 1192-1202.
18 February 2016
eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Huerta-Cepas, J., Szklarczyk, D., Forslund, K., Cook, H., Heller, D., Walter, M.C., Rattei, T., Mende, D.R., Sunagawa, S., Kuhn, M., Jensen, L.J., von Mering, C. and Bork, P.
Nucleic Acids Research 44
(D1): D286-D293.
4 January 2016
The SIDER database of drugs and side effects.
Kuhn, M., Letunic, I., Jensen, L.J. and Bork, P.
Nucleic Acids Research 44
(D1): D1075-D1079.
4 January 2016
STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.
Szklarczyk, D., Santos, A., von Mering, C., Jensen, L.J., Bork, P. and Kuhn, M.
Nucleic Acids Research 44
(D1): D380-D384.
4 January 2016
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K., Hildebrandt, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., Pedersen, H.K., Arumugam, M., Kristiansen, K., Voigt, A.Y., Vestergaard, H., Hercog, R., Costea, P.I., Kultima, J.R., Li, J., Jørgensen, T., Levenez, F., Dore, J., Nielsen, H.B., Brunak, S., Raes, J., Hansen, T., Wang, J., Ehrlich, S.D., Bork, P. and Pedersen, O.
Nature 528
(7581): 262-266.
10 December 2015
Operon structure and cotranslational subunit association direct protein assembly in bacteria.
Shieh, Y.W., Minguez, P., Bork, P., Auburger, J.J., Guilbride, D.L., Kramer, G. and Bukau, B.
Science 350
(6261): 678-680.
6 November 2015
Patterns and ecological drivers of ocean viral communities.
Brum, J.R., Ignacio-Espinoza, J.C., Roux, S., Doulcier, G., Acinas, S.G., Alberti, A., Chaffron, S., Cruaud, C., de Vargas, C., Gasol, J.M., Gorsky, G., Gregory, A.C., Guidi, L., Hingamp, P., Iudicone, D., Not, F., Ogata, H., Pesant, S., Poulos, B.T., Schwenck, S.M., Speich, S., Dimier, C., Kandels-Lewis, S., Picheral, M., Searson, S., Bork, P., Bowler, C., Sunagawa, S., Wincker, P., Karsenti, E. and Sullivan, M.B.
Science 348
(6237): 1261498.
22 May 2015
Determinants of community structure in the global plankton interactome.
Lima-Mendez, G., Faust, K., Henry, N., Decelle, J., Colin, S., Carcillo, F., Chaffron, S., Ignacio-Espinosa, J.C., Roux, S., Vincent, F., Bittner, L., Darzi, Y., Wang, J., Audic, S., Berline, L., Bontempi, G., Cabello, A.M., Coppola, L., Cornejo-Castillo, F.M., d' Ovidio, F., De Meester, L., Ferrera, I., Garet-Delmas, M.J., Guidi, L., Lara, E., Pesant, S., Royo-Llonch, M., Salazar, G., Sanchez, P., Sebastian, M., Souffreau, C., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Gorsky, G., Not, F., Ogata, H., Speich, S., Stemmann, L., Weissenbach, J., Wincker, P., Acinas, S.G., Sunagawa, S., Bork, P., Sullivan, M.B., Karsenti, E., Bowler, C., de Vargas, C. and Raes, J.
Science 348
(6237): 1262073.
22 May 2015
Structure and function of the global ocean microbiome.
Sunagawa, S., Coelho, L.P., Chaffron, S., Kultima, J.R., Labadie, K., Salazar, G., Djahanschiri, B., Zeller, G., Mende, D.R., Alberti, A., Cornejo-Castillo, F.M., Costea, P.I., Cruaud, C., d'Ovidio, F., Engelen, S., Ferrera, I., Gasol, J.M., Guidi, L., Hildebrand, F., Kokoszka, F., Lepoivre, C., Lima-Mendez, G., Poulain, J., Poulos, B.T., Royo-Llonch, M., Sarmento, H., Vieira-Silva, S., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Bowler, C., de Vargas, C., Gorsky, G., Grimsley, N., Hingamp, P., Iudicone, D., Jaillon, O., Not, F., Ogata, H., Pesant, S., Speich, S., Stemmann, L., Sullivan, M.B., Weissenbach, J., Wincker, P., Karsenti, E., Raes, J., Acinas, S.G. and Bork, P.
Science 348
(6237): 1261359.
22 May 2015
Environmental characteristics of Agulhas rings affect interocean plankton transport.
Villar, E., Farrant, G.K., Follows, M., Garczarek, L., Speich, S., Audic, S., Bittner, L., Blanke, B., Brum, J.R., Brunet, C., Casotti, R., Chase, A., Dolan, J.R., d'Ortenzio, F., Gattuso, J.P., Grima, N., Guidi, L., Hill, C.N., Jahn, O., Jamet, J.L., Le Goff, H., Lepoivre, C., Malviya, S., Pelletier, E., Romagnan, J.B., Roux, S., Santini, S., Scalco, E., Schwenck, S.M., Tanaka, A., Testor, P., Vannier, T., Vincent, F., Zingone, A., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Acinas, S.G., Bork, P., Boss, E., de Vargas, C., Gorsky, G., Ogata, H., Pesant, S., Sullivan, M.B., Sunagawa, S., Wincker, P., Karsenti, E., Bowler, C., Not, F., Hingamp, P. and Iudicone, D.
Science 348
(6237): 1261447.
22 May 2015
Eukaryotic plankton diversity in the sunlit ocean.
de Vargas, C., Audic, S., Henry, N., Decelle, J., Mahe, F., Logares, R., Lara, E., Berney, C., Le Bescot, N., Probert, I., Carmichael, M., Poulain, J., Romac, S., Colin, S., Aury, J.M., Bittner, L., Chaffron, S., Dunthorn, M., Engelen, S., Flegontova, O., Guidi, L., Horak, A., Jaillon, O., Lima-Mendez, G., Lukes, J., Malviya, S., Morard, R., Mulot, M., Scalco, E., Siano, R., Vincent, F., Zingone, A., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Acinas, S.G., Bork, P., Bowler, C., Gorsky, G., Grimsley, N., Hingamp, P., Iudicone, D., Not, F., Ogata, H., Pesant, S., Raes, J., Sieracki, M.E., Speich, S., Stemmann, L., Sunagawa, S., Weissenbach, J., Wincker, P. and Karsenti, E.
Science 348
(6237): 1261605.
22 May 2015
Computational eco-systems biology in Tara Oceans: translating data into knowledge.
Sunagawa, S., Karsenti, E., Bowler, C. and Bork, P.
Molecular Systems Biology 11
(5): 809.
21 May 2015
Temporal and technical variability of human gut metagenomes.
Voigt, A.Y., Costea, P.I., Kultima, J.R., Li, S.S., Zeller, G., Sunagawa, S. and Bork, P.
Genome Biology 16
(1): 73.
8 April 2015
Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.
Lluch-Senar, M., Delgado, J., Chen, W.-H., Llorens-Rico, V., O'Reilly, F.J., Wodke, J.A.H., Unal, E.B., Yus, E., Martinez, S., Nichols, R.J., Ferrar, T., Vivancos, A., Schmeisky, A., Stuelke, J., van Noort, V., Gavin, A.-C., Bork, P. and Serrano, L.
Molecular Systems Biology 11
(1): 780.
21 January 2015
Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller, G., Tap, J., Voigt, A.Y., Sunagawa, S., Kultima, J.R., Costea, P.I., Amiot, A., Boehm, J., Brunetti, F., Habermann, N., Hercog, R., Koch, M., Luciani, A., Mende, D.R., Schneider, M.A., Schrotz-King, P., Tournigand, C., Tran Van Nhieu, J., Yamada, T., Zimmermann, J., Benes, V., Kloor, M., Ulrich, C.M., von Knebel Doeberitz, M., Sobhani, I. and Bork, P.
Molecular Systems Biology 10
(11): 766.
28 November 2014
An integrated catalog of reference genes in the human gut microbiome.
Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J.R., Prifti, E., Nielsen, T., Juncker, A.S., Manichanh, C., Chen, B., Zhang, W., Levenez, F., Wang, J., Xu, X., Xiao, L., Liang, S., Zhang, D., Zhang, Z., Chen, W., Zhao, H., Al-Aama, J.Y., Edris, S., Yang, H., Wang, J., Hansen, T., Nielsen, H.B., Brunak, S., Kristiansen, K., Guarner, F., Pedersen, O., Dore, J., Ehrlich, S.D., Bork, P. and Wang, J.
Nature Biotechnology 32
(8): 834-841.
August 2014
Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
Nielsen, H.B., Almeida, M., Juncker, A.S., Rasmussen, S., Li, J., Sunagawa, S., Plichta, D.R., Gautier, L., Pedersen, A.G., Le Chatelier, E., Pelletier, E., Bonde, I., Nielsen, T., Manichanh, C., Arumugam, M., Batto, J.M., Quintanilha Dos Santos, M.B., Blom, N., Borruel, N., Burgdorf, K.S., Boumezbeur, F., Casellas, F., Dore, J., Dworzynski, P., Guarner, F., Hansen, T., Hildebrand, F., Kaas, R.S., Kennedy, S., Kristiansen, K., Kultima, J.R., Leonard, P., Levenez, F., Lund, O., Moumen, B., Le Paslier, D., Pons, N., Pedersen, O., Prifti, E., Qin, J., Raes, J., Sorensen, S., Tap, J., Tims, S., Ussery, D.W., Yamada, T., Renault, P., Sicheritz-Ponten, T., Bork, P., Wang, J., Brunak, S. and Ehrlich, S.D.
Nature Biotechnology 32
(8): 822-828.
August 2014
Evolution and functional cross-talk of protein post-translational modifications.
Beltrao, P., Bork, P., Krogan, N.J. and van Noort, V.
Molecular Systems Biology 9
: 714.
22 December 2013
Metagenomic species profiling using universal phylogenetic marker genes.
Sunagawa, S., Mende, D.R., Zeller, G., Izquierdo-Carrasco, F., Berger, S.A., Kultima, J.R., Coelho, L.P., Arumugam, M., Tap, J., Nielsen, H.B., Rasmussen, S., Brunak, S., Pedersen, O., Guarner, F., de Vos, W.M., Wang, J., Li, J., Dore, J., Ehrlich, S.D., Stamatakis, A. and Bork, P.
Nature Methods 10
(12): 1196-1199.
December 2013
Accurate and universal delineation of prokaryotic species.
Mende, D.R., Sunagawa, S., Zeller, G. and Bork, P.
Nature Methods 10
(9): 881-884.
September 2013
Genomic variation landscape of the human gut microbiome.
Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D.R., Kultima, J.R., Martin, J., Kota, K., Sunyaev, S.R., Weinstock, G.M. and Bork, P.
Nature 493
(7430): 45-50.
3 January 2013
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.
Iskar, M., Zeller, G., Blattmann, P., Campillos, M., Kuhn, M., Kaminska, K.H., Runz, H., Gavin, A.C., Pepperkok, R., van Noort, V. and Bork, P.
Molecular Systems Biology 9
: 662.
2013
Systematic identification of proteins that elicit drug side effects.
Kuhn, M., Al Banchaabouchi, M., Campillos, M., Jensen, L.J., Gross, C., Gavin, A.C. and Bork, P.
Molecular Systems Biology 9
: 663.
2013
Deciphering a global network of functionally associated post-translational modifications.
Minguez, P., Parca, L., Diella, F., Mende, D.R., Kumar, R., Helmer-Citterich, M., Gavin, A.C., van Noort, V. and Bork, P.
Molecular Systems Biology 8
: 599.
17 July 2012
Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours.
Yamada, T., Waller, A.S., Raes, J., Zelezniak, A., Perchat, N., Perret, A., Salanoubat, M., Patil, K.R., Weissenbach, J. and Bork, P.
Molecular Systems Biology 8
: 581.
8 May 2012
Enterotypes of the human gut microbiome.
Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D.R., Fernandes, G.R., Tap, J., Bruls, T., Batto, J.M., Bertalan, M., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H.B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E.G., Wang, J., Guarner, F., Pedersen, O., de Vos, W.M., Brunak, S., Dore, J., Weissenbach, J., Ehrlich, S.D. and Bork, P.
Nature 473
(7346): 174-180.
12 May 2011
Ontologies in quantitative biology: a basis for comparison, integration, and discovery.
Jensen, L.J. and Bork, P.
PLoS Biology 8
(5): e1000374.
25 May 2010
Ageing-related chromatin defects through loss of the NURD complex.
Pegoraro, G., Kubben, N., Wickert, U., Goehler, H., Hoffmann, K. and Misteli, T.
Nature Cell Biology 11
(10): 1261-1267.
October 2009
Biochemistry. Not comparable, but complementary.
Jensen, L.J. and Bork, P.
Science 322
(5898): 56-57.
3 October 2008
Drug target identification using side-effect similarity.
Campillos, M., Kuhn, M., Gavin, A.C., Jensen, L.J. and Bork, P.
Science 321
(5886): 263-266.
11 July 2008
The genome of the model beetle and pest tribolium castaneum.
Nature 452
(7190): 949-955.
24 April 2008
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch, M.A., Gong, M., Chowdhury, D., Senenko, L., Engel, K., Lee, Y.A., de Silva, U., Bailey, S.L., Witte, T., Vyse, T.J., Kere, J., Pfeiffer, C., Harvey, S., Wong, A., Koskenmies, S., Hummel, O., Rohde, K., Schmidt, R.E., Dominiczak, A.F., Gahr, M., Hollis, T., Perrino, F.W., Lieberman, J. and Huebner, N.
Nature Genetics 39
(9): 1065-1067.
September 2007
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C., Marenholz, I., Kerscher, T., Rueschendorf, F., Esparza-Gordillo, J., Worm, M., Gruber, C., Mayr, G., Albrecht, M., Rohde, K., Schulz, H., Wahn, U., Huebner, N. and Lee, Y.A.
PLoS Biology 5
(9): e242.
September 2007
Systematic discovery of in vivo phosphorylation networks.
Linding, R., Jensen, L.J., Ostheimer, G.J., van Vugt, M.A., Jorgensen, C., Miron, I.M., Diella, F., Colwill, K., Taylor, L., Elder, K., Metalnikov, P., Nguyen, V., Pasculescu, A., Jin, J., Park, J.G., Samson, L.D., Woodgett, J.R., Russell, R.B., Bork, P., Yaffe, M.B. and Pawson, T.
Cell 129
(7): 1415-1426.
29 June 2007
Insights into social insects from the genome of the honeybee Apis mellifera.
Nature 443
(7114): 931-949.
26 October 2006
Co-evolution of transcriptional and post-translational cell-cycle regulation.
Jensen, L.J., Jensen, T.S., de Lichtenberg, U., Brunak, S. and Bork, P.
Nature 443
(7111): 594-597.
4 October 2006
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
Witt, H., Sahin-Toth, M., Landt, O., Chen, J.M., Kaehne, T., Drenth, J.P., Kukor, Z., Szepessy, E., Halangk, W., Dahm, S., Rohde, K., Schulz, H.U., Le Marechal, C., Akar, N., Ammann, R.W., Truninger, K., Bargetzi, M., Bhatia, E., Castellani, C., Cavestro, G.M., Cerny, M., Destro-Bisol, G., Spedini, G., Eiberg, H., Jansen, J.B., Koudova, M., Rausova, E., Macek, M., Malats, N., Real, F.X., Menzel, H.J., Moral, P., Galavotti, R., Pignatti, P.F., Rickards, O., Spicak, J., Zarnescu, N.O., Boeck, W., Gress, T.M., Friess, H., Ockenga, J., Schmidt, H., Pfuetzer, R., Loehr, M., Simon, P., Weiss, F.U., Lerch, M.M., Teich, N., Keim, V., Berg, T., Wiedenmann, B., Luck, W., Groneberg, D.A., Becker, M., Keil, T., Kage, A., Bernardova, J., Braun, M., Gueldner, C., Halangk, J., Rosendahl, J., Witt, U., Treiber, M., Nickel, R. and Ferec, C.
Nature Genetics 38
(6): 668-673.
June 2006
Toward automatic reconstruction of a highly resolved tree of life.
Ciccarelli, F.D., Doerks, T., von Mehring, C., Creevey, C.J., Snel, B. and Bork, P.
Science 311
(5765): 1283-1287.
3 March 2006
Literature mining for the biologist: from information retrieval to biological discovery.
Jensen, L.J., Saric, J. and Bork, P.
Nature Reviews Genetics 7
(2): 119-129.
February 2006
The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates.
Nothnagel, M. and Rohde, K.
American Journal of Human Genetics 77
(6): 988-998.
1 December 2005
Initial sequence of the chimpanzee genome and comparison with the human genome.
Mikkelsen, T.S., Hillier, L.W., Eichler, E.E., Zody, M.C., Jaffe, D.B., Yang, S.P., Enard, W., Hellmann, I., Lindblad-Toh, K., Altheide, T.K., Archidiacono, N., Bork, P., Butler, J., Chang, J.L., Cheng, Z., Chinwalla, A.T., de Jong, P., Delehaunty, K.D., Fronick, C.C., Fulton, L.L., Gilad, Y., Glusman, G., Gnerre, S., Graves, T.A., Hayakawa, T., Hayden, K.E., Huang, X.Q., Ji, H.K., Kent, W.J., King, M.C., Kulbokas, E.J., Lee, M.K., Liu, G., Lopez-Otin, C., Makova, K.D., Man, O., Mardis, E.R., Mauceli, E., Miner, T.L., Nash, W.E., Nelson, J.O., Paeaebo, S., Patterson, N.J., Pohl, C.S., Pollard, K.S., Pruefer, K., Puente, X.S., Reich, D., Rocchi, M., Rosenbloom, K., Ruvolo, M., Richter, D.J., Schaffner, S.F., Smit, A.F.A., Smith, S.M., Suyama, M., Taylor, J., Torrents, D., Tuzun, E., Varki, A., Velasco, G., Ventura, M., Wallis, J.W., Wendl, M.C., Wilson, R.K., Lander, E.S. and Waterston, R.H.
Nature 437
(7055): 69-87.
1 September 2005
Systematic association of genes to phenotypes by genome and literature mining.
Korbel, J.O., Doerks, T., Jensen, L.J., Perez-Iratxeta, C., Kaczanowski, S., Hooper, S.D., Andrade, M.A. and Bork, P.
PLoS Biology 3
(5): e134.
5 April 2005
Dynamic complex formation during the yeast cell cycle.
de Lichtenberg, U., Jensen, L.J., Brunak, S. and Bork, P.
Science 307
(5710): 724-727.
4 February 2005
Complex genomic rearrangements lead to novel primate gene function.
Ciccarelli, F.D., von Mering, C., Suyama, M., Harrington, E.D., Izaurralde, E. and Bork, P.
Genome Research 15
(3): 343-351.
1 January 2005
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.
Hillier, L.W., Miller, W., Birney, E., Warren, W., Hardison, R.C., Ponting, C.P., Bork, P., Burt, D.W., Groenen, M.A.M., Delany, M.E., Dodgson, J.B., Chinwalla, A.T., Cliften, P.F., Clifton, S.W., Delehaunty, K.D., Fronick, C., Fulton, R.S., Graves, T.A., Kremitzki, C., Layman, D., Magrini, V., McPherson, J.D., Miner, T.L., Minx, P., Nash, W.E., Nhan, M.N., Nelson, J.O., Oddy, L.G., Pohl, C.S., Randall-Maher, J., Smith, S.M., Wallis, J.W., Yang, S.P., Romanov, M.N., Rondelli, C.M., Paton, B., Smith, J., Morrice, D., Daniels, L., Tempest, H.G., Robertson, L., Masabanda, J.S., Griffin, D.K., Vignal, A., Fillon, V., Jacobbson, L., Kerje, S., Andersson, L., Crooijmans, R.P.M., Aerts, J., van der Poel, J.J., Ellegren, H., Caldwell, R.B., Hubbard, S.J., Grafham, D.V., Kierzek, A.M., McLaren, S.R., Overton, I.M., Arakawa, H., Beattie, K.J., Bezzubov, Y., Boardman, P.E., Bonfield, J.K., Croning, M.D.R., Davies, R.M., Francis, M.D., Humphray, S.J., Scott, C.E., Taylor, R.G., Tickle, C., Brown, W.R.A., Rogers, J., Buerstedde, J.M., Wilson, S.A., Stubbs, L., Ovcharenko, I., Gordon, L., Lucas, S., Miller, M.M., Inoko, H., Shiina, T., Kaufman, J., Salomonsen, J., Skjoedt, K., Wong, G.K.S., Wang, J., Liu, B., Wang, J., Yu, J., Yang, H.M., Nefedov, M., Koriabine, M., de Jong, P.J., Goodstadt, L., Webber, C., Dickens, N.J., Letunic, I., Suyama, M., Torrents, D., von Mering, C., Zdobnov, E.M., Makova, K., Nekrutenko, A., Elnitski, L., Eswara, P., King, D.C., Yang, S., Tyekucheva, S., Radakrishnan, A., Harris, R.S., Chiaromonte, F., Taylor, J., He, J.B., Rijnkels, M., Griffiths-Jones, S., Ureta-Vidal, A., Hoffman, M.M., Severin, J., Searle, S.M.J., Law, A.S., Speed, D., Waddington, D., Cheng, Z., Tuzun, E., Eichler, E., Bao, Z.R., Flicek, P., Shteynberg, D.D., Brent, M.R., Bye, J.M., Huckle, E.J., Chatterji, S., Dewey, C., Pachter, L., Kouranov, A., Mourelatos, Z., Hatzigeorgiou, A.G., Paterson, A.H., Ivarie, R., Brandstrom, M., Axelsson, E., Backstrom, N., Berlin, S., Webster, M.T., Pourquie, O., Reymond, A., Ucla, C., Antonarakis, S.E., Long, M.Y., Emerson, J.J., Betran, E., Dupanloup, I., Kaessmann, H., Hinrichs, A.S., Bejerano, G., Furey, T.S., Harte, R.A., Raney, B., Siepel, A., Kent, W.J., Haussler, D., Eyras, E., Castelo, R., Abril, J.F., Castellano, S., Camara, F., Parra, G., Guigo, R., Bourque, G., Tesler, G., Pevzner, P.A., Smit, A., Fulton, L.A., Mardis, E.R. and Wilson, R.K.
Nature 432
(7018): 695-716.
9 December 2004
Analysis of genomic context: prediction of functional associations from conserved bidirectionally transcribed gene pairs.
Korbel, J.O., Jensen, L.J., von Mering, C. and Bork, P.
Nature Biotechnology 22
(7): 911-917.
1 July 2004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs, R.A., Weinstock, G.M., Metzker, M.L., Muzny, D.M., Sodergren, E.J., Scherer, S., Scott, G., Steffen, D., Worley, K.C., Burch, P.E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R., Holt, R.A., Adams, M.D., Amanatides, P.G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans, C.A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C.L., Nguyen, T., Pfannkoch, C.M., Sitter, C., Sutton, G.G., Venter, J.C., Woodage, T., Smith, D., Lee, H.M., Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss, R.B., Dunn, D.M., Green, E.D., Blakesley, R.W., Bouffard, G.G., de Jong, P.J., Osoegawa, K., Zhu, B., Marra, M., Schein, J., Bosdet, I., Fjell, C., Jones, S., Krzywinski, M., Mathewson, C., Siddiqui, A., Wye, N., McPherson, J., Zhao, S., Fraser, C.M., Shetty, J., Shatsman, S., Geer, K., Chen, Y., Abramzon, S., Nierman, W.C., Havlak, P.H., Chen, R., Durbin, K.J., Egan, A., Ren, Y., Song, X.Z., Li, B., Liu, Y., Qin, X., Cawley, S., Worley, K.C., Cooney, A.J., D'Souza, L.M., Martin, K., Wu, J.Q., Gonzalez-Garay, M.L., Jackson, A.R., Kalafus, K.J., McLeod, M.P., Milosavljevic, A., Virk, D., Volkov, A., Wheeler, D.A., Zhang, Z., Bailey, J.A., Eichler, E.E., Tuzun, E., Birney, E., Mongin, E., Ureta-Vidal, A., Woodwark, C., Zdobnov, E., Bork, P., Suyama, M., Torrents, D., Alexandersson, M., Trask, B.J., Young, J.M., Huang, H., Wang, H., Xing, H., Daniels, S., Gietzen, D., Schmidt, J., Stevens, K., Vitt, U., Wingrove, J., Camara, F., Alba, M.M., Abril, J.F., Guigo, R., Smit, A., Dubchak, I., Rubin, E.M., Couronne, O., Poliakov, A., Hübner, N., Ganten, D., Goesele, C., Hummel, O., Kreitler, T., Lee, Y.A., Monti, J., Schulz, H., Zimdahl, H., Himmelbauer, H., Lehrach, H., Jacob, H.J., Bromberg, S., Gullings-Handley, J., Jensen-Seaman, M.I., Kwitek, A.E., Lazar, J., Pasko, D., Tonellato, P.J., Twigger, S., Ponting, C.P., Duarte, J.M., Rice, S., Goodstadt, L., Beatson, S.A., Emes, R.D., Winter, E.E., Webber, C., Brandt, P., Nyakatura, G., Adetobi, M., Chiaromonte, F., Elnitski, L., Eswara, P., Hardison, R.C., Hou, M., Kolbe, D., Makova, K., Miller, W., Nekrutenko, A., Riemer, C., Schwartz, S., Taylor, J., Yang, S., Zhang, Y., Lindpaintner, K., Andrews, T.D., Caccamo, M., Clamp, M., Clarke, L., Curwen, V., Durbin, R., Eyras, E., Searle, S.M., Cooper, G.M., Batzoglou, S., Brudno, M., Sidow, A., Stone, E.A., Venter, J.C., Payseur, B.A., Bourque, G., Lopez-Otin, C., Puente, X.S., Chakrabarti, K., Chatterji, S., Dewey, C., Pachter, L., Bray, N., Yap, V.B., Caspi, A., Tesler, G., Pevzner, P.A., Haussler, D., Roskin, K.M., Baertsch, R., Clawson, H., Furey, T.S., Hinrichs, A.S., Karolchik, D., Kent, W.J., Rosenbloom, K.R., Trumbower, H., Weirauch, M., Cooper, D.N., Stenson, P.D., Ma, B., Brent, M., Arumugam, M., Shteynberg, D., Copley, R.R., Taylor, M.S., Riethman, H., Mudunuri, U., Peterson, J., Guyer, M., Felsenfeld, A., Old, S., Mockrin, S. and Collins, F.
Nature 428
(6982): 493-521.
1 April 2004
A molecular genetic and statistical approach for the diagnosis of dual-site cancers.
Brinkmann, D., Ryan, A., Ayhan, A., McCluggage, W.G., Feakins, R., Santibanez-Koref, M.F., Mein, C.A., Gayther, S.A. and Jacobs, I.J.
Journal of the National Cancer Institute 96
(19): 1441-1446.
1 January 2004
Global analysis of bacterial transcription factors to predict cellular target processes.
Doerks, T., Andrade, M.A., Lathe, W., von Mering, C. and Bork, P.
Trends in Genetics 20
(3): 126-131.
1 January 2004
Estimating rates of alternative splicing in mammals and invertebrates.
Harrington, E.D., Boue, S., Valcarcel, J., Reich, J.G. and Bork, P.
Nature Genetics 36
(9): 916-917.
1 January 2004
The HUPO PSI's Molecular Interaction format - a community standard for the representation of protein interaction data.
Hermjakob, H., Montecchi-Palazzi, L., Bader, G., Wojcik, R., Salwinski, L., Ceol, A., Moore, S., Orchard, S., Sarkans, U., von Mering, C., Roechert, B., Poux, S., Jung, E., Mersch, H., Kersey, P., Lappe, M., Li, Y.X., Zeng, R., Rana, D., Nikolski, M., Husi, H., Brun, C., Shanker, K., Grant, S.G.N., Sander, C., Bork, P., Zhu, W.M., Pandey, A., Brazma, A., Jacq, B., Vidal, M., Sherman, D., Legrain, P., Cesareni, G., Xenarios, L., Eisenberg, D., Steipe, B., Hogue, C. and Apweiler, R.
Nature Biotechnology 22
(2): 177-183.
1 January 2004
The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold.
Ciccarelli, F.D., Bork, P. and Kerkhoff, E.
Trends in Biochemical Sciences 28
(7): 349-352.
7 July 2003
Systematic discovery of analogous enzymes in thiamin biosynthesis.
Morett, E., Korbel, J., Rajan, E., Saab-Rincon, G., Olvera, L., Olvera, M., Steffen, S., Snel, B. and Bork, P.
Nature Biotechnology 21
(7): 790-795.
July 2003
Metabolites: a helping hand for pathway evolution?
Schmidt, S., Sunyaev, S., Bork, P. and Dandekar, T.
Trends in Biochemical Sciences 28
(6): 336-341.
June 2003
Increase of functional diversity by alternative splicing.
Kriventseva, E.V., Koch, I., Apweiler, R., Vingron, M., Bork, P., Gelfand, M.S. and Sunyaev, S.
Trends in Genetics 19
(3): 124-128.
March 2003
Genome evolution reveals biochemical networks and functional modules.
von Mering, C., Zdobnov, E.M., Tsoka, S., Ciccarelli, F.D., Pereira-Leal, J.B., Ouzounis, C.A. and Bork, P.
Proceedings of the National Academy of Sciences of the United States of America 100
(26): 15428-15433.
1 January 2003
Metabolic network structure determines key aspects of functionality and regulation.
Stelling, J., Klamt, S., Bettenbrock, K., Schuster, S. and Gilles, E.D.
Nature 420
(6912): 190-193.
14 November 2002
Worldwide scientific publishing activity.
Perez-Iratxeta, C. and Andrade, M.A.
Science 297
(5581): 519-519.
26 July 2002
Association of genes to genetically inherited diseases using data mining.
Perez-Iratxeta, C., Bork, P. and Andrade, M.A.
Nature Genetics 31
(3): 316-319.
July 2002
Genome organization: Teamed up for transcription.
von Mering, C. and Bork, P.
Nature 417
(6891): 797-798.
20 June 2002
Mapping of gene loci for nephronophthisis type 4 and Senior-Loken syndrome, to chromosome 1p36.
Schuermann, M.J., Otto, E., Becker, A., Saar, K., Rueschendorf, F., Polak, B.C., Ala-Mello, S., Hoefele, J., Wiedensohler, A., Haller, M., Omran, H., Nuernberg, P. and Hildebrandt, F.
American Journal of Human Genetics 70
(5): 1240-1246.
May 2002
Embryonic stem cells - The debate in Germany.
Reich, J.G.
Science 296
(5566): 265-265.
12 April 2002
BSD: a novel domain in transcription factors and synapse-associated proteins.
Doerks, T., Huber, S., Buchner, E. and Bork, P.
Trends in Biochemical Sciences 27
(4): 168-170.
1 April 2002
Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms (Reprinted from Current Opinion in Structural Biology, vol 11, pg 125-130, 2001).
Sunyaev, S.R., Lathe, W. and Bork, P.
Trends in Genetics
(Suppl. March): S19-S24.
March 2002
Alternative splicing and genome complexity.
Brett, D., Pospisil, H., Valcarel, J., Reich, J. and Bork, P.
Nature Genetics 30
(1): 29-30.
1 January 2002
CASH - a beta-helix domain widespread among carbohydrate-binding proteins.
Ciccarelli, F.D., Copley, R.R., Doerks, T., Russell, R.B. and Bork, P.
Trends in Biochemical Sciences 27
(2): 59-62.
1 January 2002
AMOP, a protein module aternativelly spliced in cancer cells.
Ciccarelli, F.D., Doerks, T. and Bork, P.
Trends in Biochemical Sciences 27
: 113-115.
1 January 2002
Inversions and the dynamics of eukaryotic gene order.
Huynen, M.A., Snel, B. and Bork, P.
Trends in Genetics 17
(6): 304-306.
1 June 2001
The draft sequences. Filling in the gaps.
Bork, P. and Copley, R.
Nature 409
(6822): 818-820.
15 February 2001
Initial sequencing and analysis of the human genome.
Lander, E.S., Linton, L.M., Birren, B., Nusbaum, C., Zody, M.C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., McEwan, P., McKernan, K., Meldrim, J., Mesirov, J.P., Miranda, C., Morris, W., Naylor, J., Raymond, C., Rosetti, M., Santos, R., Sheridan, A., Sougnez, C., Stange-Thomann, N., Stojanovic, N., Subramanian, A., Wyman, D., Rogers, J., Sulston, J., Ainscough, R., Beck, S., Bentley, D., Burton, J., Clee, C., Carter, N., Coulson, A., Deadman, R., Deloukas, P., Dunham, A., Dunham, I., Durbin, R., French, L., Grafham, D., Gregory, S., Hubbard, T., Humphray, S., Hunt, A., Jones, M., Lloyd, C., McMurray, A., Matthews, L., Mercer, S., Milne, S., Mullikin, J.C., Mungall, A., Plumb, R., Ross, M., Shownkeen, R., Sims, S., Waterston, R.H., Wilson, R.K., Hillier, L.W., McPherson, J.D., Marra, M.A., Mardis, E.R., Fulton, L.A., Chinwalla, A.T., Pepin, K.H., Gish, W.R., Chissoe, S.L., Wendl, M.C., Delehaunty, K.D., Miner, T.L., Delehaunty, A., Kramer, J.B., Cook, L.L., Fulton, R.S., Johnson, D.L., Minx, P.J., Clifton, S.W., Hawkins, T., Branscomb, E., Predki, P., Richardson, P., Wenning, S., Slezak, T., Doggett, N., Cheng, J.F., Olsen, A., Lucas, S., Elkin, C., Uberbacher, E., Frazier, M., Gibbs, R.A., Muzny, D.M., Scherer, S.E., Bouck, J.B., Sodergren, E.J., Worley, K.C., Rives, C.M., Gorrell, J.H., Metzker, M.L., Naylor, S.L., Kucherlapati, R.S., Nelson, D.L., Weinstock, G.M., Sakaki, Y., Fujiyama, A., Hattori, M., Yada, T., Toyoda, A., Itoh, T., Kawagoe, C., Watanabe, H., Totoki, Y., Taylor, T., Weissenbach, J., Heilig, R., Saurin, W., Artiguenave, F., Brottier, P., Bruls, T., Pelletier, E., Robert, C., Wincker, P., Rosenthal, A., Platzer, M., Nyakatura, G., Taudien, S., Rump, A., Yang, H.M., Yu, J., Wang, J., Huang, G.Y., Gu, J., Hood, L., Rowen, L., Madan, A., Qin, S.Z., Davis, R.W., Federspiel, N.A., Abola, A.P., Proctor, M.J., Myers, R.M., Schmutz, J., Dickson, M., Grimwood, J., Cox, D.R. and Olson, M.V.
Nature 409
(6822): 860-921.
15 February 2001
A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22.
Vanita, A., Singh, J.R., Sarhadi, V.K., Singh, D., Reis, A., Rueschendorf, F., Becker-Follmann, J., Jung, M. and Sperling, K.
American Journal of Human Genetics 68
(2): 509-514.
February 2001
DDT - a novel domain in different transcription and chromosome remodeling factors.
Doerks, T., Copley, R. and Bork, P.
Trends in Biochemical Sciences 26
: 145-146.
1 January 2001
XplorMed: a tool for exploring MEDLINE abstracts.
Perez-Iratxeta, C., Bork, P. and Andrade, M.A.
Trends in Biochemical Sciences 26
(9): 573-575.
1 January 2001
Cooperation and competition in the evolution of ATP-producing pathways.
Pfeiffer, T., Schuster, S. and Bonhoeffer, S.
Science 292
: 504-507.
1 January 2001
Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms.
Sunyaev, S.R., Lathe, W. and Bork, P.
Current Opinion in Structural Biology 11
(1): 125-130.
1 January 2001
Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15.
Stoeber, G., Saar, K., Rueschendorf, F., Meyer, J., Nuernberg, G., Jatzke, S., Franzek, E., Reis, A., Lesch, K.P., Wienker, T.F. and Beckmann, H.
American Journal of Human Genetics 67
: 1201-1207.
1 November 2000
GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins.
Doerks, T., Strauss, M., Brendel, M. and Bork, P.
Trends in Biochemical Sciences 25
(10): 483-485.
1 October 2000
Gene context conservation of a higher order than operons.
Lathe, W.C., Snel, B. and Bork, P.
Trends in Biochemical Sciences 25
(10): 474-479.
1 October 2000
Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Lee, Y.A., Rueschendorf, F., Windemuth, C., Schmitt-Egenolf, M., Stadelmann, A., Nuernberg, G., Staender, M., Wienker, T.F., Reis, A. and Traupe, H.
American Journal of Human Genetics 67
(4): 1020-1024.
1 October 2000
EST analysis online: WWW tools for detection of SNPs and alternative splice forms.
Brett, D., Lehmann, G., Hanke, J., Gross, S., Reich, J. and Bork, P.
Trends in Genetics 16
(9): 416-418.
1 September 2000
SNP frequencies in human genes - an excess of rare alleles and differing modes of selection.
Sunyaev, S.R., Lathe, W.C., Ramensky, V.E. and Bork, P.
Trends in Genetics 16
(8): 335-337.
1 August 2000
L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7.
Doerks, T., Bork, P., Kamberov, E., Makarova, O., Muecke, S. and Margolis, B.
Trends in Biochemical Sciences 25
: 317-318.
1 July 2000
Automated annotation of GPI anchor sites: case study C-elegans.
Eisenhaber, B., Bork, P., Yuan, Y.P., Loeffler, G. and Eisenhaber, F.
Trends in Biochemical Sciences 25
(7): 340-341.
1 July 2000
Sequences and topology. Genome and proteome informatics - Editorial overview.
Bork, P. and Eisenberg, D.
Current Opinion in Structural Biology 10
(3): 341-342.
1 June 2000
Exploitation of gene context.
Huynen, M.A., Snel, B., Lathe, W. and Bork, P.
Current Opinion in Structural Biology 10
(3): 366-370.
1 June 2000
More than 1,000 putative new human signalling proteins revealed by EST data mining.
Schultz, J., Doerks, T., Ponting, C.P., Copley, R.R. and Bork, P.
Nature Genetics 25
(2): 201-204.
1 June 2000
Towards a structural basis of human non-synonymous single nucleotide polymorphisms.
Sunyaev, S.R., Ramensky, V. and Bork, P.
Trends in Genetics 16
(5): 198-200.
1 May 2000
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks.
Schuster, S., Fell, D.A. and Dandekar, T.
Nature Biotechnology 18
(3): 326-332.
1 March 2000
The GeneQuiz web server: protein functional analysis through the Web.
Hoersch, S., Leroy, C., Brown, N.P., Andrade, M.A. and Sander, C.
Trends in Biochemical Sciences 25
(1): 33-35.
28 January 2000
A cholesterol-lowering gene maps to chromosome 13q.
Knoblauch, H., Mueller-Myhsok, B., Busjahn, A., Avi, L.B., Bähring, S., Baron, H., Heath, S.C., Uhlmann, R., Faulhaber, H.D., Shpitzen, S., Aydin, A., Reshef, A., Rosenthal, M., Eliav, O., Muhl, A., Lowe, A., Schurr, D., Harats, D., Jeschke, E., Friedlander, Y., Schuster, H., Luft, F.C. and Leitersdorf, E.
American Journal of Human Genetics 66
(1): 157-166.
1 January 2000
Genome evolution - gene fusion versus gene fission.
Snel, B., Bork, P. and Huynen, M.
Trends in Genetics 16
: 9-11.
1 January 2000
Lateral gene transfer, genome surveys, and the phylogeny of prokaryotes.
Huynen, M.A., Snel, B. and Bork, P.
Science 286
(5444): 1443a.
19 November 1999
View from the east.
Reich, J.G.
Science 286
(5442): 1087-1087.
5 November 1999
Alternative splicing of human genes - more the rule than the exception?
Hanke, J., Brett, D., Zastrow, I., Aydin, A., Delbrueck, S., Lehmann, G., Luft, F.C., Reich, J. and Bork, P.
Trends in Genetics 15
: 389-390.
1 October 1999
Domains in plexins: links to integrins and transcription factors.
Bork, P., Doerks, T., Springer, T.A. and Snel, B.
Trends in Biochemical Sciences 24
: 261-263.
1 July 1999
A novel transactivation domain in parkin.
Morett, E. and Bork, P.
Trends in Biochemical Sciences 24
: 229-231.
1 June 1999
The mahogany protein is a receptor involved in suppression of obesity.
Nagle, D.L., McGrail, S.H., Vitale, J., Wolf, E.A., Dussault, B.J., DiRocco, L., Holmgren, L., Montagno, J., Bork, P., Huszar, D., Fairchild-Huntress, V., Ge, P., Keilty, J., Ebeling, C., Baldini, L., Gilchrist, J., Burn, P., Carlson, G.A. and Moore, K.J.
Nature 398
: 148-152.
11 March 1999
Genome phylogeny based on gene content.
Snel, B., Bork, P. and Huynen, M.A.
Nature Genetics 21
: 108-110.
1 January 1999
Conservation of gene order: a fingerprint of proteins that physically interact.
Dandekar, T., Snel, B., Huynen, M. and Bork, P.
Trends in Biochemical Sciences 23
(9): 324-328.
1 September 1998
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.
Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K.M., Chrzanowska, K.H., Saar, K., Beckmann, G., Seemanova, E., Cooper, P.R., Nowak, N.J., Stumm, M., Weemaes, C.M.R., Gatti, R.A., Wilson, R.K., Digweed, M., Rosenthal, A., Sperling, K., Concannon, P. and Reis, A.
Cell 93
(3): 467-476.
1 May 1998
Predicting functions from protein sequences - where are the bottlenecks?
Bork, P. and Koonin, E.V.
Nature Genetics 18
: 313-318.
1 January 1998
Protein annotation: detective work for function prediction.
Doerks, T., Bairoch, A. and Bork, P.
Trends in Genetics 14
: 248-250.
1 January 1998
Wanted: subcellular localization of proteins based on sequence.
Eisenhaber, F. and Bork, P.
Trends in Cell Biology 8
: 169-170.
1 January 1998
Gene families: the taxonomy of protein paralogs and chimeras.
Henikoff, S., Greene, E.A., Pietrokovski, S., Bork, P., Attwood, T.K. and Hood, L.
Science 278
(5338): 609-614.
24 October 1997
Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in south african afrikaans-speakers.
Starfield, M., Hennies, H.C., Jung, M., Jenkins, T., Wienker, T.F., Hull, P., Spurdle, A., Kuester, W., Ramsay, M. and Reis, A.
American Journal of Human Genetics 61
(2): 370-378.
August 1997
A novel class of RanGTP binding proteins.
Goerlich, D., Dabrowski, M., Bischoff, F.R., Kutay, U., Bork, P., Hartmann, E., Prehn, S. and Izaurralde, E.
Journal of Cell Biology 138
(1): 65-80.
14 July 1997
The gene for the ataxia telangiectasia variant, nijmegen breakage syndrome, maps to a 1 cm interval on chromosome 8q21.
Saar, K., Chrzanowska, K.H., Stumm, M., Jung, M., Nuernberg, G., Wienker, T.F., Seemanova, E., Wegner, R.D., Reis, A. and Sperling, K.
American Journal of Human Genetics 60
(3): 605-610.
March 1997
Cytoplasmic signalling domains: the next generation.
Bork, P., Schultz, J. and Ponting, C.P.
Trends in Biochemical Sciences 22
: 296-298.
1 January 1997
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
Bork, P., Hofmann, K., Bucher, P., Neuwald, A., Altschul, S.F. and Koonin, E.V.
FASEB Journal 11
(1): 68-76.
1 January 1997
Deletion at 12p in a japanese child with brachydactyly overlaps the assigned locus of brachydactyly with hypertension in a turkish family.
Bähring, S., Nagai, T., Toka, H.R., Nitz, I., Toka, O., Aydin, A., Muhl, A., Wienker, T.F., Schuster, H. and Luft, F.C.
American Journal of Human Genetics 60
: 732-735.
1 January 1997
Genome maps 8. Building gene families. Wall chart.
Greene, E.A., Pietrokovski, S., Henikoff, S., Bork, P., Attwood, T.K., Hood, L. and Bairoch, A.
Science 278
: 615-626.
1 January 1997
A putative nucleic acid-binding domain in Werner's and Bloom's syndrome helicases.
Morozov, V., Mushegian, A.R., Koonin, E.V. and Bork, P.
Trends in Biochemical Sciences 22
: 417-418.
1 January 1997
SPRY domains in ryanodine receptors (Ca2+ release channels).
Ponting, C., Schultz, J. and Bork, P.
Trends in Biochemical Sciences 22
: 193-194.
1 January 1997
Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.
Rohde, K., Teare, M.D. and Koref, M.S.
American Journal of Human Genetics 61
: 418-422.
1 January 1997
Secreted fringe like signaling molecules may be glycosyltransferases.
Yuan, Y.P., Schultz, J., Mlodzik, M. and Bork, P.
Cell 88
: 9-11.
1 January 1997
BRCA1 protein products ... Functional motifs...
Koonin, E.V., Altschul, S.F. and Bork, P.
Nature Genetics 13
(3): 266-268.
1 July 1996
Sperm-egg binding protein or proto-oncogene?
Bork, P.
Science 271
(5254): 1431-1432.
1 January 1996
Internal repeats in the BRCA2 protein sequence.
Bork, P., Blomberg, N. and Nilges, M.
Nature Genetics 13
: 22-23.
1 January 1996
Go hunting in sequence databases but watch out for the traps.
Bork, P. and Bairoch, A.
Trends in Genetics 12
: 425-427.
1 January 1996
Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction.
Gibson, T., Koonin, E.V., Musco, G., Pastore, A. and Bork, P.
Trends in Neurosciences 19
: 465-468.
1 January 1996
Ancient duplication of dna polymerase inferred from analysis of complete bacterial genomes.
Koonin, E.V. and Bork, P.
Trends in Biochemical Sciences 21
(4): 128-129.
1 January 1996
Non-orthologous gene displacement.
Koonin, E.V., Mushegian, A.R. and Bork, P.
Trends in Genetics 12
: 334-336.
1 January 1996
Identification and mutation analysis of the complete gene for the Chediak-Higashi syndrome.
Nagle, D.L., Karim, M., Woolf, E.A., Holmgren, L., Bork, P., Misumi, D., McGrail, D., Dussault, J.R., Duyk, G., Spritz, R.A. and Moore, K.J.
Nature Genetics 14
: 307-312.
1 January 1996
Pleckstrin's repeat performance: a novel domain in g protein signaling.
Ponting, C.P. and Bork, P.
Trends in Biochemical Sciences 21
: 245-246.
1 January 1996
Severe autosomal dominant hypertension and brachydactyly in a unique turkish kindred maps to human chromosome 12.
Schuster, H., Wienker, T.F., Bähring, S., Bilginturan, N., Toka, H.R., Neitzel, H., Jeschke, E., Toka, O., Gilbert, D., Lowe, A., Ott, J., Haller, H. and Luft, F.C.
Nature Genetics 13
(1): 98-100.
1 January 1996
Heat repeats in Huntington's disease protein.
Andrade, M.A. and Bork, P.
Nature Genetics 11
(2): 115-116.
1 October 1995
Polycystic kidney disease: the complete structure of the PKD1 gene and its protein.
Gluecksmann-Kuis, M.A., Tayber, O., Woolf, E.A., Bougueleret, L., Deng, N.H., Alperin, G.D., Iris, F., Hawkins, F., Munro, C., Lakey, N., Duyk, G., Schneider, M.C., Geng, L., Zhang, F., Zhao, Z.H., Torosian, S., Zhou, J., Reeders, S.T., Bork, P., Pohlschmidt, M., Lohning, C., Kraus, B., Nowicka, U., Leung, A.L.S. and Frischauf, A.M.
Cell 81
(2): 289-298.
21 April 1995
A phosphotyrosine interaction domain.
Bork, P. and Margolis, B.
Cell 80
(5): 693-694.
1 January 1995
Challenging times for bioinformatics.
Casari, G., Andrade, M.A., Bork, P., Daruvar, A., Ouzounis, C., Schneider, R., Tamames, J., Valencia, A. and Sander, C.
Nature 376
: 647-648.
1 January 1995
The WW domain: a signalling site in dystrophin.
Bork, P. and Sudol, M.
Trends in Biochemical Sciences 19
(12): 531-533.
1 December 1994
Yeast chromosome III: new gene functions.
Koonin, E., Bork, P. and Sander, C.
EMBO Journal 13
: 493-503.
1 January 1994
An adhesive domain detected in functionally diverse receptors.
Beckmann, G. and Bork, P.
Trends in Biochemical Sciences 18
: 40-41.
1 January 1993
Molecular modelling of the norrie disease protein predicts a cystine knot growth factor tertiary structure.
Meitinger, T., Meindl, A., Bork, P., Rost, B., Sander, C., Haasemann, M. and Murken, J.
Nature Genetics 5
: 376-380.
1 January 1993
Proposed acquisition of an animal protein domain by bacteria.
Bork, P. and Doolittle, R.F.
Proceedings of the National Academy of Sciences of the United States of America 89
: 8990-8994.
1 January 1992
Reszka, Regina
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Jacobs, A., Voges, J., Reszka, R., Lercher, M., Gossmann, A., Kracht, L., Kaestle, C., Wagner, R., Wienhard, K. and Heiss, W.D.
Lancet 358
(9283): 727-729.
1 January 2001
S100A1: A regulator of myocardial contractility.
Most, P., Bernotat, J., Ehlermann, P., Pleger, S.T., Reppel, M., Boerries, M., Niroomand, F., Pieske, B., Janssen, P.M.L., Eschenhagen, T., Karczewski, P., Smith, G.L., Koch, W.J.K., Katus, H.A. and Remppis, A.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13889-13894.
1 January 2001
Both beta2- and beta1-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling ofbeta2-adrenergic receptors to G(s)-protein.
Molenaar, P., Bartel, S., Cochrane, A., Vetter, D., Jalali, H., Pohlner, P., Burrell, K., Karczewski, P., Krause, E.G. and Kaumann, A.
Circulation 102
(15): 1814-1821.
10 October 2000
Robson, Michael (BIMSB)
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel, A.R., Szabo, Q., Chiariello, A.M., Chudzik, K., Schöpflin, R., Rothe, P., Mattei, A.L., Zehnder, To., Harnett, D., Laupert, V., Bianco, S., Hetzel, S., Glaser, J., Phan, M.H.Q., Schindler, M., Ibrahim, D.M., Paliou, C., Esposito, A., Prada-Medina, C.A., Haas, S.A., Giere, P., Vingron, M., Wittler, L., Meissner, A., Nicodemi, M., Cavalli, G., Bantignies, F., Mundlos, S. and Robson, M.I.
Cell 185
(20): 3689-3704.
29 September 2022
Rocks, Oliver
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M., Rademacher, J., Bagshaw, R.D., Wortmann, C., Barth, C., van Unen, J., Alp, K.M., Giudice, G., Eccles, R.L., Heinrich, L.E., Pascual-Vargas, P., Sanchez-Castro, M., Brandenburg, L., Mbamalu, G., Tucholska, M., Spatt, L., Czajkowski, M.T., Welke, R.W., Zhang, S., Nguyen, V., Rrustemi, T., Trnka, P., Freitag, K., Larsen, B., Popp, O., Mertins, P., Gingras, A.C., Roth, F.P., Colwill, K., Bakal, C., Pertz, O., Pawson, T., Petsalaki, E. and Rocks, O.
Nature Cell Biology 22
(4): 498-511.
April 2020
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C., Grabiger, S., Schwefel, D., Faelber, K., Rosenbaum, E., Mears, J., Rocks, O. and Daumke, O.
EMBO Journal 32
(9): 1280-1292.
2 May 2013
Roetzschke, Olaf
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119
(22): 2904-2912.
9 June 2009
A xenon-129 biosensor for monitoring MHC-peptide interactions.
Schlundt, A., Kilian, W., Beyermann, M., Sticht, J., Guenther, S., Hoepner, S., Falk, K., Roetzschke, O., Mitschang, L. and Freund, C.
Angewandte Chemie International Edition 48
(23): 4142-4145.
25 May 2009
In vivo-activated CD103+ Foxp3+ Tregs: of men and mice.
Roetzschke, O., Borsellino, G., Battistini, L., Falk, K. and Kleinewietfeld, M.
Blood 113
(9): 2119-2120.
26 February 2009
CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells.
Kleinewietfeld, M., Starke, M., Mitri, D.D., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 113
(4): 827-836.
22 January 2009
Hydrolysis of extracellular ATP by CD39+ Treg cells: context matters!
Kleinewietfeld, M., Dimitri, D., Sternjak, A., Diamantini, A., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 111
(2): 965-966.
15 January 2008
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.
Borsellino, G., Kleinewietfeld, M., Di Mitri, D., Sternjak, A., Diamantini, A., Giometto, R., Hoepner, S., Centonze, D., Bernardi, G., Dell'Acqua, M.L., Rossini, P.M., Battistini, L., Roetzschke, O. and Falk, K.
Blood 110
(4): 1225-1232.
15 August 2007
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W.
Nature Immunology 7
(4): 392-400.
April 2006
CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset.
Kleinewietfeld, M., Puentes, F., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 105
(7): 2877-2886.
1 January 2005
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Roetzschke, O., Lau, J.M., Hofstätter, M., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 99
(26): 16946-16950.
24 December 2002
The final cut: how ERAP1 trims MHC ligands to size.
Falk, K. and Roetzschke, O.
Nature Immunology 3
(12): 1121-1122.
December 2002
Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope.
Stienekemeier, M., Falk, K., Roetzschke, O., Weishaupt, A., Schneider, C., Toyka, K.V., Gold, R. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13872-13877.
1 November 2001
Rosenbauer, Frank
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer, J., Walter, C., Tönges, A., Aleth, H., Costa Jordão, M.J., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., Vogl, T., Prinz, M., Dugas, M., Jacobsen, I.D. and Rosenbauer, F.
Nature Immunology 20
(5): 546-558.
May 2019
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Staber, P.B., Zhang, P., Ye, M., Welner, R.S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B.A., Zhang, H., Alberich-Jorda, M., Lee, S., Yang, H., Ng, F., Zhang, J., Leddin, M., Silberstein, L.E., Hoefler, G., Orkin, S.H., Goettgens, B., Rosenbauer, F., Huang, G. and Tenen, D.G.
Molecular Cell 49
(5): 934-946.
7 March 2013
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M., Vockentanz, L., Kharazi, S., Huska, M.R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., Nerlov, C., Leutz, A., Andrade-Navarro, M.A., Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41
(11): 1207-1215.
November 2009
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Ebralidze, A.K., Guibal, F.C., Steidl, U., Zhang, P., Lee, S., Bartholdy, B., Jorda, M.A., Petkova, V., Rosenbauer, F., Huang, G., Dayaram, T., Klupp, J., O'Brien, K.B., Will, B., Hoogenkamp, M., Borden, K.L., Bonifer, C. and Tenen, D.G.
Genes & Development 22
(15): 2085-2092.
1 August 2008
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., Kobayashi, S., Costa, D.B., Schulz, T., OBrien, K.B., Verhaak, R.G.W., Delwel, R., Haase, D., Truemper, L., Krauter, J., Kohwi-Shigematsu, T., Griesinger, F. and Tenen, D.G.
Journal of Clinical Investigation 117
(9): 2611-2620.
4 September 2007
Transcription factors in myeloid development: balancing differentiation with transformation.
Rosenbauer, F. and Tenen, D.G.
Nature Reviews Immunology 7
(2): 105-117.
February 2007
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
Steidl, U., Rosenbauer, F., Verhaak, R.G.W., Gu, X., Ebralidze, A., Otu, H.H., Klippel, S., Steidl, C., Bruns, I., Costa, D.B., Wagner, K., Aivado, M., Kobbe, G., Valk, P.J.M., Passegue, E., Libermann, T.A., Delwel, R. and Tenen, D.G.
Nature Genetics 38
(11): 1269-1277.
November 2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7
(10): 1037-1047.
October 2006
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C. and Tenen, D.G.
Nature Genetics 38
(1): 27-37.
January 2006
Rosenthal, Walter
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J.P., Cooper, D.M.F., Knapp, S., Rademann, J., Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52
(46): 12187-12191.
11 November 2013
Rybak-Wolf, Agnieszka (BIMSB)
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20
(10): 1544-1552.
October 2023
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8
(7): 1252-1266.
July 2023
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.
Piwecka, M., Rajewsky, N. and Rybak-Wolf, A.
Nature Reviews Neurology 19
(6): 346–362.
June 2023
Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H.C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N. and Hilgers, V.
Cell 186
(11): 2438-2455.
25 May 2023
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
Sander, Maike
Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang, G., Chiou, J., Zeng, C., Miller, M., Matta, I., Han, J.Y., Kadakia, N., Okino, M.L., Beebe, E., Mallick, M., Camunas-Soler, J., Dos Santos, T., Dai, X.Q., Ellis, C., Hang, Y., Kim, S.K., MacDonald, P.E., Kandeel, F.R., Preissl, S., Gaulton, K.J. and Sander, M.
Nature Genetics 55
(6): 984-994.
June 2023
The 4D nucleome project.
Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J. and Zhong, S.
Nature 549
(7671): 219-226.
14 September 2017
Stem cell epigenetics: looking forward.
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Lim, D.A., Meshorer, E., Pombo, A., Sander, M. and Xu, G.L.
Cell Stem Cell 14
(6): 706-709.
5 June 2014
Role of adrenal renin in the regulation of adrenal steroidogenesis corticotropin.
Sander, M., Ganten, D. and Mellon, S.H.
Proceedings of the National Academy of Sciences of the United States of America 91
(1): 148-152.
4 January 1994
Sanders, Ashley (MDC/BIMSB/BIH)
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
Leppä, A.M., Grimes, K., Jeong, H., Huang, F.Y., Andrades, A., Waclawiczek, A., Boch, T., Jauch, A., Renders, S., Stelmach, P., Müller-Tidow, C., Karpova, D., Sohn, M., Grünschläger, F., Hasenfeld, P., Benito Garagorri, E., Thiel, V., Dolnik, A., Rodriguez-Martin, B., Bullinger, L., Mrózek, K., Eisfeld, A.K., Krämer, A., Sanders, A.D., Korbel, J.O. and Trumpp, A.
Nature Genetics 56
(12): 2790-2803.
December 2024
p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10
(43): eadp8783.
25 October 2024
Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.
Grimes, K., Jeong, H., Amoah, A., Xu, N., Niemann, J., Raeder, B., Hasenfeld, P., Stober, C., Rausch, T., Benito, E., Jann, J.C., Nowak, D., Emini, R., Hoenicka, M., Liebold, A., Ho, A., Shuai, S., Geiger, H., Sanders, A.D. and Korbel, J.O.
Nature Genetics 56
(6): 1134-1146.
June 2024
Unlocking the secrets of structural variants in a healthy tissue.
Korbel, J.O. and Sanders, A.D.
Nature Genetics 56
(6): 1047-1048.
June 2024
Pangenome graph construction from genome alignments with Minigraph-Cactus.
Hickey, G., Monlong, J., Ebler, J., Novak, A.M., Eizenga, J.M., Gao, Y., Marschall, T., Li, H. and Paten, B.
Nature Biotechnology 42
(4): 663-673.
April 2024
Functional analysis of structural variants in single cells using Strand-seq.
Jeong, H., Grimes, K., Rauwolf, K.K., Bruch, P.M., Rausch, T., Hasenfeld, P., Benito, E., Roider, T., Sabarinathan, R., Porubsky, D., Herbst, S.A., Erarslan-Uysal, B., Jann, J.C., Marschall, T., Nowak, D., Bourquin, J.P., Kulozik, A.E., Dietrich, S., Bornhauser, B., Sanders, A.D. and Korbel, J.O.
Nature Biotechnology 41
(6): 832-844.
June 2023
Recombination between heterologous human acrocentric chromosomes.
Guarracino, A., Buonaiuto, S., de Lima, L.G., Potapova, T., Rhie, A., Koren, S., Rubinstein, B., Fischer, C., Gerton, J.L., Phillippy, A.M., Colonna, V. and Garrison, E.
Nature 617
(7960): 335-343.
11 May 2023
A draft human pangenome reference.
Liao, W.W., Asri, M., Ebler, J., Doerr, D., Haukness, M., Hickey, G., Lu, S., Lucas, J.K., Monlong, J., Abel, H.J., Buonaiuto, S., Chang, X.H., Cheng, H., Chu, J., Colonna, V., Eizenga, J.M., Feng, X., Fischer, C., Fulton, R.S., Garg, S., Groza, C., Guarracino, A., Harvey, W.T., Heumos, S., Howe, K., Jain, M., Lu, T.Y., Markello, C., Martin, F.J., Mitchell, M.W., Munson, K.M., Mwaniki, M.N., Novak, A.M., Olsen, H.E., Pesout, T., Porubsky, D., Prins, P., Sibbesen, J.A., Sirén, J., Tomlinson, C., Villani, F., Vollger, M.R., Antonacci-Fulton, L.L., Baid, G., Baker, C.A., Belyaeva, A., Billis, K., Carroll, A., Chang, P.C., Cody, S., Cook, D.E., Cook-Deegan, R.M., Cornejo, O.E., Diekhans, M., Ebert, P., Fairley, S., Fedrigo, O., Felsenfeld, A.L., Formenti, G., Frankish, A., Gao, Yan, Garrison, N.A., Giron, C.G., Green, R.E., Haggerty, L., Hoekzema, K., Hourlier, T., Ji, H.P., Kenny, E.E., Koenig, B.A., Kolesnikov, A., Korbel, J.O., Kordosky, J., Koren, S., Lee, H.J., Lewis, A.P., Magalhães, H., Marco-Sola, S., Marijon, P., McCartney, A., McDaniel, J., Mountcastle, J., Nattestad, M., Nurk, S., Olson, N.D., Popejoy, A.B., Puiu, D., Rautiainen, M., Regier, A.A., Rhie, A., Sacco, S., Sanders, A.D., Schneider, V.A., Schultz, B.I., Shafin, K., Smith, M.W., Sofia, H.J., Abou Tayoun, A.N., Thibaud-Nissen, F., Tricomi, F.F., Wagner, J., Walenz, B., Wood, J.M.D., Zimin, A.V., Bourque, G., Chaisson, M.J P, Flicek, Paul, Phillippy, A.M., Zook, J.M., Eichler, E.E., Haussler, D., Wang, T., Jarvis, E.D., Miga, K.H., Garrison, E., Marschall, T., Hall, I.M., Li, H. and Paten, B.
Nature 617
(7960): 312-324.
11 May 2023
Increased mutation and gene conversion within human segmental duplications.
Vollger, M.R., Dishuck, P.C., Harvey, W.T., DeWitt, W.S., Guitart, X., Goldberg, M.E., Rozanski, A.N., Lucas, J., Asri, M., Munson, K.M., Lewis, A.P., Hoekzema, K., Logsdon, G.A., Porubsky, D., Paten, B., Harris, K., Hsieh, P.H. and Eichler, E.E.
Nature 617
(7960): 325-334.
11 May 2023
Inversion polymorphism in a complete human genome assembly.
Porubsky, D., Harvey, W.T., Rozanski, A.N., Ebler, J., Höps, W., Ashraf, H., Hasenfeld, P., Paten, B., Sanders, A.D., Marschall, T., Korbel, J.O. and Eichler, E.E.
Genome Biology 24
(1): 100.
30 April 2023
Single-cell multi-omics allows functional characterization of structural variants.
Korbel, J.O. and Sanders, A.D.
Nature Biotechnology
24 November 2022
Semi-automated assembly of high-quality diploid human reference genomes.
Jarvis, E.D., Formenti, G., Rhie, A., Guarracino, A., Yang, C., Wood, J., Tracey, A., Thibaud-Nissen, F., Vollger, M.R., Porubsky, D., Cheng, H., Asri, M., Logsdon, G.A., Carnevali, P., Chaisson, M.J.P., Chin, C.S., Cody, S., Collins, J., Ebert, P., Escalona, M., Fedrigo, O., Fulton, R.S., Fulton, L.L., Garg, S., Gerton, J.L., Ghurye, J., Granat, A., Green, R.E., Harvey, W., Hasenfeld, P., Hastie, A., Haukness, M., Jaeger, E.B., Jain, M., Kirsche, M., Kolmogorov, M., Korbel, J.O., Koren, S., Korlach, J., Lee, J., Li, D., Lindsay, T., Lucas, J., Luo, F., Marschall, T., Mitchell, M.W., McDaniel, J., Nie, F., Olsen, H.E., Olson, N.D., Pesout, T., Potapova, T., Puiu, D., Regier, A., Ruan, J., Salzberg, S.L., Sanders, A.D., Schatz, M.C., Schmitt, A., Schneider, V.A., Selvaraj, S., Shafin, K., Shumate, A., Stitziel, N.O., Stober, C., Torrance, J., Wagner, J., Wang, J., Wenger, A., Xiao, C., Zimin, A.V., Zhang, G., Wang, T., Li, H., Garrison, E., Haussler, D., Hall, I., Zook, J.M., Eichler, E.E., Phillippy, A.M., Paten, B., Howe, K. and Miga, K.H.
Nature 611
(7936): 519-531.
17 November 2022
Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
Letizia, M., Wang, Y.H., Kaufmann, U., Gerbeth, L., Sand, A., Brunkhorst, M., Weidner, P., Ziegler, J.F., Böttcher, C., Schlickeiser, S., Fernández, C., Yamashita, M., Stauderman, K., Sun, K., Kunkel, D., Prakriya, M., Sanders, A.D., Siegmund, B., Feske, S. and Weidinger, C.
EMBO Molecular Medicine 14
(9): e15687.
7 September 2022
Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
Porubsky, D., Höps, W., Ashraf, H., Hsieh, P.H., Rodriguez-Martin, B., Yilmaz, F., Ebler, J., Hallast, P., Maggiolini, F.A.M., Harvey, W.T., Henning, B., Audano, P.A., Gordon, D.S., Ebert, P., Hasenfeld, P., Benito, E., Zhu, Q., Lee, C., Antonacci, F., Steinrücken, M., Beck, C.R., Sanders, A.D., Marschall, T., Eichler, E.E. and Korbel, J.O.
Cell 185
(11): 1986-2005.
26 May 2022
Sattentau, Quentin James
Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15
(1): 6851.
10 August 2024
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z., Zhang, S., Dupont, M., Ragaller, F., Sjule, E., Cabezas-Caballero, J., Deimel, L.P., Robertson, H., Russell, R.A., Dushek, O., Sezgin, E., Karaji, N. and Sattentau, Q.J.
Nature Communications 15
(1): 541.
15 January 2024
Sauer, Sascha (BIMSB/BIH)
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C., Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S., Tajbakhsh, S., Höpken, U.E. and Stricker, S.
Immunity 56
(6): 1204-1219.
13 June 2023
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55
(5): 880-890.
May 2023
BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13
(1): 1577.
24 March 2022
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić, S., Prada-Medina, C.A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C.M., Antony, P., Timmermann, B., Sauer, S., Pereira, S.L., Schwamborn, J.C., May, P., Grünewald, A. and Spielmann, M.
Brain 145
(3): 964-978.
March 2022
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K., Fogo, M.S., Pinto, B.G.G., Alves, A.Y., Suzuki, A.M., Morales, A.G., Ezquina, S., Sosa, O.J., Sutton, G.J., Sunaga-Franze, D.Y., Bueno, A.P., Seabra, G., Sardinha, L., Costa, S.S., Rosenberg, C., Zachi, E.C., Sertie, A.L., Martins-de-Souza, D., Reis, E.M., Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26
(5): 1589-1605.
May 2021
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J., Heuberger, J., Vidal, R., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. and Birchmeier, W.
Nature Communications 11
(1): 6422.
21 December 2020
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel, B., Czimmerer, Z., Halasz, L., Boto, P., Kolostyak, Z., Poliska, S., Berger, W.K., Tzerpos, P., Nagy, G., Horvath, A., Hajas, G., Cseh, T., Nagy, A., Sauer, S., Francois-Deleuze, J., Szatmari, I., Bacsi, A. and Nagy, L.
Genes & Development 34
(21-22): 1474-1492.
1 November 2020
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D. and le Noble, F.
Nature Communications 11
(1): 5319.
21 October 2020
Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B., Alonso, G., Georgana, I., El-Jesr, M., Martín, R., Shair, K.H.Y., Fischer, C., Sauer, S., Maluquer de Motes, C. and Alcamí, A.
Science Advances 6
(38): eabb4565.
18 September 2020
Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W., Shang, F., Wang, X., Fanti, A.K., Greco, A., Busch, K., Klapproth, K., Zhang, Q., Quedenau, C., Sauer, S., Feyerabend, T.B., Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27
(3): 383-395.
3 September 2020
Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
Preussner, M., Gao, Q., Morrison, E., Herdt, O., Finkernagel, F., Schumann, M., Krause, E., Freund, C., Chen, W. and Heyd, F.
Genome Biology 21
(1): 186.
29 July 2020
Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E., Lafzi, A., Moutinho, C., Ziegenhain, C., McCarthy, D.J., Álvarez-Varela, A., Batlle, E., Sagar, Grün, D., Lau, J.K., Boutet, S.C., Sanada, C., Ooi, A., Jones, R.C., Kaihara, K., Brampton, C., Talaga, Y., Sasagawa, Y., Tanaka, K., Hayashi, T., Braeuning, C., Fischer, C., Sauer, S., Trefzer, T., Conrad, C., Adiconis, X., Nguyen, L.T., Regev, A., Levin, J.Z., Parekh, S., Janjic, A., Wange, L.E., Bagnoli, J.W., Enard, W., Gut, M., Sandberg, R., Nikaido, I., Gut, I., Stegle, O. and Heyn, H.
Nature Biotechnology 38
(6): 747-755.
June 2020
CRISPLD1: a novel conserved target in the transition to human heart failure.
Khadjeh, S., Hindmarsh, V., Weber, F., Cyganek, L., Vidal, R.O., Torkieh, S., Streckfuss-Bömeke, K., Lbik, D., Tiburcy, M., Mohamed, B.A., Bonn, S., Toischer, K. and Hasenfuss, G.
Basic Research in Cardiology 115
(3): 27.
7 March 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
Pivovarova-Ramich, O., Markova, M., Weber, D., Sucher, S., Hornemann, S., Rudovich, N., Raila, J., Sunaga-Franze, D., Sauer, S., Rohn, S., Pfeiffer, A.F.H. and Grune, T.
Redox Biology 29
(2): 101397.
January 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C., Berger, H., Antanaviciute, A., Vidal, R., Sauer, S., Simmons, A., Meyer, T.F. and Sigal, M.
Nature Communications 10
(1): 4368.
25 September 2019
R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M., Del Mar Reinés, M., Müllerke, S., Fischer, C., Kapalczynska, M., Berger, H., Bakker, E.R.M., Mollenkopf, H.J., Rothenberg, M.E., Wiedenmann, B., Sauer, S. and Meyer, T.F.
Nature Cell Biology 21
(7): 812-823.
July 2019
A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
Hernáez, B., Alonso-Lobo, J.M., Montanuy, I., Fischer, C., Sauer, S., Sigal, L., Sevilla, N. and Alcamí, A.
Nature Communications 9
(1): 5440.
21 December 2018
The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B., Nagy, G., Czimmerer, Z., Horvath, A., Hammers, D.W., Cuaranta-Monroy, I., Poliska, S., Tzerpos, P., Kolostyak, Z., Hays, T.T., Patsalos, A., Houtman, R., Sauer, S., Francois-Deleuze, J., Rastinejad, F., Balint, B.L., Sweeney, H.L. and Nagy, L.
Immunity 49
(4): 615-626.
16 October 2018
The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B., Nagy, G., Horvath, A., Czimmerer, Z., Cuaranta-Monroy, I., Poliska, S., Hays, T.T., Sauer, S., Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46
(9): 4425-4439.
18 May 2018
Faecal microbiota composition associates with abdominal pain in the general population.
Hadizadeh, F., Bonfiglio, F., Belheouane, M., Vallier, M., Sauer, S., Bang, C., Bujanda, L., Andreasson, A., Agreus, L., Engstrand, L., Talley, N.J., Rafter, J., Baines, J.F., Walter, S., Franke, A. and D'Amato, M.
Gut 67
(4): 778-779.
8 March 2018
The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z., Daniel, B., Horvath, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M.M., Cuaranta-Monroy, I., Simandi, Z., Steiner, L., Nagy, B., Poliska, S., Banko, C., Bacso, Z., Schulman, I.G., Sauer, S., Deleuze, J.F., Allen, J.E., Benko, S. and Nagy, L.
Immunity 48
(1): 75-90.
16 January 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M., Klinger, B., Klünemann, M., Sieber, A., Uhlitz, F., Sauer, S., Garnett, M.J., Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9
(1): 20.
2 January 2018
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W., Feyerabend, T.B., Rössler, J., Wang, X., Postrach, D., Busch, K., Rode, I., Klapproth, K., Dietlein, N., Quedenau, C., Chen, W., Sauer, S., Wolf, S., Höfer, T. and Rodewald, H.Re.
Nature 548
(7668): 456-460.
24 August 2017
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Stunnenberg, H.G. and Hirst, M.
Cell 167
(7): 1145-1149.
17 November 2016
OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
Simandi, Z., Horvath, A., Wright, L.C., Cuaranta-Monroy, I., De Luca, I., Karolyi, K., Sauer, S., Deleuze, J.F., Gudas, L.J., Cowley, S.M. and Nagy, L.
Molecular Cell 63
(4): 647-661.
18 August 2016
Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S.F., Powell, C.A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G.F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J.A., Frye, M., Prokisch, H. and Minczuk, M.
Nature Communications 7
: 12039.
30 June 2016
A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M., Grossmann, A., Woodsmith, J., Özkan, Z., Birth, P., Meierhofer, D., Benlasfer, N., Valovka, T., Timmermann, B., Wanker, E.E., Sauer, S. and Stelzl, U.
Nature Methods 10
(4): 339-342.
April 2013
Association and linkage of allelic variants of the dopamine transporter gene in ADHD.
Friedel, S., Saar, K., Sauer, S., Dempfle, A., Walitza, S., Renner, T., Romanos, M., Freitag, C., Seitz, C., Palmason, H., Scherag, A., Windemuth-Kieselbach, C., Schimmelmann, B.G., Wewetzer, C., Meyer, J., Warnke, A., Lesch, K.P., Reinhardt, R., Herpertz-Dahlmann, B., Linder, M., Hinney, A., Remschmidt, H., Schaefer, H., Konrad, K., Huebner, N. and Hebebrand, J.
Molecular Psychiatry 12
(10): 923-933.
October 2007
Sawamiphak, Suphansa
The significant impact of experimental variables on the gut microbiome.
Zakarauskas-Seth, B.I. and Sawamiphak, S.
Cardiovascular Research 120
(10): 1100-1101.
July 2024
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
Zaupa, M., Nagaraj, N., Sylenko, A., Baier, H., Sawamiphak, S. and Filosa, A.
Neuron 112
(7): 1150-1164.e6.
3 April 2024
Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages.
Apaydin, O., Altaikyzy, A., Filosa, A. and Sawamiphak, S.
Developmental Cell 58
(22): 2460-2476.e7.
20 November 2023
Interferon-γ drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload.
Apaydin, D.C., Zakarauskas-Seth, B.I., Carnevale, L., Apaydin, O., Perrotta, M., Carnevale, R., Kotini, M.P., Kotlar-Goldaper, I., Belting, H.G., Carnevale, D., Filosa, A. and Sawamiphak, S.
Cardiovascular research 119
(5): 1234-1249.
May 2023
Transient cardiomyocyte fusion regulates cardiac development in zebrafish.
Sawamiphak, S., Kontarakis, Z., Filosa, A., Reischauer, S. and Stainier, D.Y.R.
Nature Communications 8
(1): 1525.
15 November 2017
Scheidereit, Claus
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts.
Kolesnichenko, M. and Scheidereit, C.
Signal Transduction and Targeted Therapy 9
(1): 179.
29 July 2024
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14
(1): 6947.
7 November 2023
TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41
(21): e110372.
2 November 2022
Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12
(6): 1653-1668.
December 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11
(1): 103-119.
February 2020
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37
(24): e98658.
14 December 2018
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann, S.M., Krueger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., Habbel, P., Kaelin, R., Franzoni, E., Rybak, A., Nguyen, D., Veh, R., Ninnemann, O., Peters, O., Nitsch, R., Heppner, F.L., Golenbock, D., Schott, E., Ploegh, H.L., Wulczyn, F.G. and Lehnardt, S.
Nature Neuroscience 15
(6): 827-835.
June 2012
It takes two to tango: IκBs, the multifunctional partners of NF-κB.
Hinz, M., Coel Arslan, S. and Scheidereit, C.
Immunological Reviews 246
(1): 59-76.
March 2012
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Doerken, B., Lenz, G., Scheidereit, C., Schmitt, C.A. and Lee, S.
Genes & Development 25
(20): 2137-2146.
15 October 2011
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz, M., Stilmann, M., Coel Arslan, S., Khanna, K.K., Dittmar, G. and Scheidereit, C.
Molecular Cell 40
(1): 63-74.
8 October 2010
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch, A., Seitz, S., Baschant, U., Schilling, A.F., Illing, A., Stride, B., Kirilov, M., Mandic, V., Takacz, A., Schmidt-Ullrich, R., Ostermay, S., Schinke, T., Spanbroek, R., Zaiss, M.M., Angel, P.E., Lerner, U.H., David, J.P., Reichardt, H.M., Amling, M., Schuetz, G. and Tuckermann, J.P.
Cell Metabolism 11
(6): 517-531.
9 June 2010
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M., Hinz, M., Coel Arslan, S., Zimmer, A., Schreiber, V. and Scheidereit, C.
Molecular Cell 36
(3): 365-378.
13 November 2009
Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y., Tomann, P., Andl, T., Gallant, N.M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M.L., Morrisey, E.E., Overbeek, P.A., Scheidereit, C., Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17
(1): 49-61.
21 July 2009
The hair follicle as a dynamic miniorgan.
Schneider, M.R., Schmidt-Ullrich, R. and Paus, R.
Current Biology 19
(3): R132-T142.
10 February 2009
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Visekruna, A., Joeris, T., Seidel, D., Kroesen, A., Loddenkemper, C., Zeitz, M., Kaufmann, S.H.E., Schmidt-Ullrich, R. and Steinhoff, U.
Journal of Clinical Investigation 116
(12): 3195-3203.
December 2006
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T.W., Ruland, J., Heissmeyer, V. and Krappmann, D.
Molecular Cell 23
(1): 13-23.
7 July 2006
Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., Heins, G., Ehrhardt, C. and Wolff, T.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13640-13645.
9 September 2005
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S., Joehrens, K., Joos, S., Lietz, A., Hummel, F., Janz, M., Jundt, F., Anagnostopoulos, I., Bommert, K., Lichter, P., Stein, H., Scheidereit, C. and Doerken, B.
Blood 106
(13): 4287-4293.
25 August 2005
Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Freund, C., Schmidt-Ullrich, R., Baurand, A., Dunger, S., Schneider, W., Loser, P., El-Jamali, A., Dietz, R., Scheidereit, C. and Bergmann, M.W.
Circulation 111
(18): 2319-2325.
1 January 2005
A dual role for lkkalpha in tooth development.
Ohazama, A., Hu, Y.L., Schmidt-Ullrich, R., Cao, Y.X., Scheidereit, C., Karin, M. and Sharpe, P.T.
Developmental Cell 6
(2): 219-227.
1 January 2004
Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M., Rolle, S., Wellner, M., Cardoso, M.C., Scheidereit, C., Luft, F.C. and Kettritz, R.
Blood 102
(6): 2259-2267.
15 September 2003
Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S., Lietz, A., Janz, M., Hinz, M., Jundt, F., Scheidereit, C., Bommert, K. and Doerken, B.
Blood 102
(3): 1028-1034.
1 August 2003
Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196
(5): 605-617.
2 September 2002
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S., Hinz, M., Anagnostopoulos, L., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dörken, B. and Scheidereit, C.
EMBO Journal 21
(15): 4104-4113.
1 August 2002
In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Mehrhof, F.B., Mueller, F.U., Bergmann, M.W., Li, P.F., Wang, Y.B., Schmitz, W., Dietz, R. and von Harsdorf, R.
Circulation 104
: 2088-2094.
1 January 2001
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
Slaugenhaupt, S.A., Blumenfeld, A., Gill, S.P., Leyne, M., Mull, J., Cuajungco, M.P., Liebert, C.B., Chadwick, B., Idelson, M., Reznik, L., Robbins, C.M., Makalowska, I., Brownstein, M.J., Krappmann, D., Scheidereit, C., Maayan, C., Axelrod, F.B. and Gusella, J.F.
American Journal of Human Genetics 68
: 598-605.
1 January 2001
NF-kappaB and the innate immune response.
Hatada, E.N., Krappmann, D. and Scheidereit, C.
Current Opinion in Immunology 12
: 52-58.
1 February 2000
NF-kappaB p105 is a target of I kappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Heissmeyer, V., Krappmann, D., Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 18
: 4766-4778.
1 September 1999
Signal transduction. Docking IkappaB kinases.
Scheidereit, C.
Nature 395
: 225-226.
17 September 1998
Different mechanisms control signal-induced degradation and basal turnover of the NF-kappab inhibitor ikappabalpha in vivo.
Krappmann, D., Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 15
(23): 6716-6726.
2 December 1996
Scherneck, Siegfried
Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1.
Janke, J., Schlueter, K., Jandrig, B., Theile, M., Koelble, K., Arnold, W., Grinstein, E., Schwartz, A., Estevez-Schwarz, L., Schlag, P.M., Jockusch, B.M. and Scherneck, S.
Journal of Experimental Medicine 191
(10): 1675-1685.
15 May 2000
Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.
Lakhani, S.R., Jacquemier, J., Sloane, J.P., Gusterson, B.A., Anderson, T.J., Vandevijver, M.J., Farid, L.M., Venter, D., Antoniou, A., Storferisser, A., Smyth, E., Steel, C.M., Haites, N., Scott, R.J., Goldgar, D., Neuhausen, S., Daly, P.A., Ormiston, W., Mcmanus, R., Scherneck, S., Ponder, B.A.J., Ford, D., Peto, J., Stoppa-Lyonnet, D., Bignon, Y.J., Struewing, J.P., Spurr, N.K., Bishop, D.T., Klijn, J.G.M., Devilee, P., Cornelisse, C.J., Lasset, C., Lenoir, G., Barkardottir, R.B., Egilsson, V., Hamann, U., Changclaude, J., Sobol, H., Weber, B., Stratton, M.R. and Easton, D.F.
Journal of the National Cancer Institute 90
(15): 1138-1145.
5 August 1998
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families.
Ford, D., Easton, D.F., Stratton, M., Narod, S., Goldgar, D., Devilee, P., Bishop, D.T., Weber, B., Lenoir, G., Chang-Claude, J., Sobol, H., Teare, M.D., Struewing, J., Arason, A., Scherneck, S., Peto, J., Rebbeck, T.R., Tonin, P., Neuhausen, S., Barkardottir, R., Eyfjord, J., Lynch, H., Ponder, B.A.J., Gayther, S.A., Birch, J.M., Lindblom, A., Stoppa-Lyonnet, D., Bignon, Y., Borg, A., Hamann, U., Haites, N., Scott, R.J., Maugard, C.M., Vasen, H., Seitz, S., Cannon-Albright, L.A., Schofield, A. and Zelada-Hedman, M.
American Journal of Human Genetics 62
(3): 676-689.
March 1998
Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases.
Lakhani, S.R., Easton, D.F., Stratton, M.R., Storferisser, A., Anderson, T.J., Farid, L.M., Gusterson, B.A., Jaquemier, J., Sloane, J.P., Venter, D., Vandevijver, M.J., Bishop, D.T., Barkardottir, R.B., Bignon, Y.J., Cornelisse, C., Changclaude, J., Daly, P.A., Devilee, P., Egilsson, V., Ford, D., Goldgar, D., Haites, N., Hamann, U., Klijn, J.G.M., Lasset, C., Lenoir, G., Mcmanus, R., Neuhausen, S., Ormiston, W., Ponder, B.A.J., Peto, J., Steel, C.M., Stoppa-Lyonnet, D., Smyth, E., Sobol, H., Spurr, N., Scott, R.J., Scherneck, S., Streuwing, J.P., Vasen, H. and Weber, B.
Lancet 349
: 1505-1510.
1 January 1997
Correlation between genotype and phenotype in patients with cystic fibrosis.
Hamosh, A., Grade, K., Coutelle, C. and Reis, A.
New England Journal of Medicine 329
(18): 1308-1313.
28 October 1993
Schiattarella, Gabriele G.
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications.
Bode, D., Pronto, J.R.D., Schiattarella, G.G. and Voigt, N.
Nature Reviews Cardiology 21
(10): 682-700.
October 2024
Systems biology approach uncovers candidates for liver-heart interorgan crosstalk in HFpEF.
Strocchi, S., Liu, L., Wang, R., Häseli, S.P., Capone, F., Bode, D., Nambiar, N., Eroglu, T., Santiago Padilla, L., Farrelly, C., Vacca, A., Mascagni, M., Oeing, C.U., Kintscher, U., Jung, S., Diezel, S.A., Liévano Contreras, S.V., Zhou, M., Seldin, M. and Schiattarella, G.G.
Circulation Research 135
(8): 873-876.
27 September 2024
Targeting HFpEF: unlocking the potential of glucagon receptor blockade.
Santiago Padilla, L. and Schiattarella, G.G.
Circulation Research 135
(5): 629-631.
16 August 2024
Lysozyme 1 inflamed CCR2(+) macrophages promote obesity-induced cardiac dysfunction.
Zhang, L., Han, H., Xu, A., Sathe, A., Fu, S., Zhao, J., Cai, W., Yang, Y., Liu, J., Bai, H., Ben, J., Zhu, X., Li, X., Yang, Q., Wang, Z., Gu, Y., Xing, C., Schiattarella, G.G., Cheng, S.Y., Zhang, H. and Chen, Q.
Circulation Research 135
(5): 596-613.
16 August 2024
Tackling metabolic defects in HFpEF.
Wang, R. and Schiattarella, G.G.
European Heart Journal 45
(17): 1494-1496.
1 May 2024
A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on pulmonary circulation & right ventricular function.
Ameri, P., Mercurio, V., Pollesello, P., Anker, M.S., Backs, Jo., Bayes-Genis, A., Borlaug, B.A., Burkhoff, D., Caravita, S., Chan, S.Y., de Man, F., Giannakoulas, G., González, A., Guazzi, M., Hassoun, P.M., Hemnes, A.R., Maack, C., Madden, B., Melenovsky, V., Müller, O.J., Papp, Z., Pullamsetti, S.S., Rainer, P.P., Redfield, M.M., Rich, S., Schiattarella, G.G., Skaara, H., Stellos, K., Tedford, R.J., Thum, T., Vachiery, J.L., van der Meer, P., Van Linthout, S., Pruszczyk, P., Seferovic, P., Coats, A.J.S., Metra, M., Rosano, G., Rosenkranz, S. and Tocchetti, C.G.
European Journal of Heart Failure 26
(4): 707-729.
April 2024
From gut to heart: role of indole-3-propionic acid in HFpEF.
Vacca, A. and Schiattarella, G.G.
Circulation Research 134
(4): 390-392.
16 February 2024
Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
Smolgovsky, S., Bayer, A.L., Kaur, K., Sanders, E., Aronovitz, M., Filipp, M.E., Thorp, E.B., Schiattarella, G.G., Hill, J.A., Blanton, R.M., Cubillos-Ruiz, J.R. and Alcaide, P.
Journal of Clinical Investigation 133
(24): e171874.
15 December 2023
Comments on the myPACE randomized clinical trial.
Rodolico, D. and Schiattarella, G.G.
JAMA Cardiology 8
(8): 794-795.
August 2023
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
Ziegler, K.A., Ahles, A., Dueck, A., Esfandyari, D., Pichler, P., Weber, K., Kotschi, S., Bartelt, A., Sinicina, I., Graw, M., Leonhardt, H., Weckbach, L.T., Massberg, S., Schifferer, M., Simons, M., Hoeher, L., Luo, J., Ertürk, A., Schiattarella, G.G., Sassi, Y., Misgeld, T. and Engelhardt, S.
Science 381
(6655): 285-290.
21 July 2023
The lure of cardiac metabolism in the diagnosis, prevention, and treatment of heart failure.
Rodolico, D., Schiattarella, G.G. and Taegtmeyer, H.
JACC: Heart Failure 11
(6): 637-645.
June 2023
Cardiometabolic HFpEF: NASH of the heart.
Capone, F., Vettor, Roberto and Schiattarella, G.G.
Circulation 147
(6): 451-453.
7 February 2023
Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint
Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial & Pericardial Diseases.
Gyöngyösi, M., Alcaide, P., Asselbergs, F.W., Brundel, B.J.J.M., Camici, G.G., da Costa Martins, P., Ferdinandy, P., Fontana, M., Girao, H., Gnecchi, M., Gollmann-Tepeköylü, C., Kleinbongard, P., Krieg, T., Madonna, R., Paillard, M., Pantazis, A., Perrino, C., Pesce, M., Schiattarella, G.G., Sluijter, J.P.G., Steffens, S., Tschöpe, C., Van Linthout, S. and Davidson, S.M.
Cardiovascular Research 119
(2): 336-356.
February 2023
Cardiac metabolism in HFpEF: from fuel to signalling.
Capone, F., Sotomayor-Flores, C., Bode, D., Wang, R., Rodolico, D., Strocchi, S. and Schiattarella, G.G.
Cardiovascular Research 118
(18): 3556-3575.
December 2022
Impaired AMP-activated protein kinase signaling in heart failure with preserved ejection fraction-associated atrial fibrillation.
Tong, D., Schiattarella, G.G., Jiang, N., Daou, D., Luo, Y., Link, M.S., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 146
(1): 73-76.
5 July 2022
Canagliflozin and myocardial oxidative stress: SGLT1 inhibition takes centre stage.
Schiattarella, G.G. and Bode, D.
European Heart Journal 42
(48): 4961-4963.
21 December 2021
Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models.
Withaar, C., Lam, C.S.P., Schiattarella, G.G., de Boer, R.A. and Meems, L.M.G.
European Heart Journal 42
(43): 4420-4430.
14 November 2021
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G., Altamirano, F., Kim, S.Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K.M., Villalobos, E., Spurgin, S.B., Waldman, M., Jiang, N., May, H.I., Hill, T.M., Luo, Y., Yoo, H., Zaha, V.G., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 12
(1): 1684.
16 March 2021
Schmidt, Deborah
Structure, interaction and nervous connectivity of beta cell primary cilia.
Müller, A., Klena, N., Pang, S., Garcia, L.E.G., Topcheva, O., Aurrecoechea Duran, S., Sulaymankhil, D., Seliskar, M., Mziaut, H., Schöniger, E., Friedland, D., Kipke, N., Kretschmar, S., Münster, C., Weitz, J., Distler, M., Kurth, T., Schmidt, D., Hess, H.F., Xu, C.S., Pigino, G. and Solimena, M.
Nature Communications 15
(1): 9168.
24 October 2024
Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets.
Müller, A., Schmidt, D., Albrecht, J.P., Rieckert, L., Otto, M., Galicia Garcia, L.E., Fabig, G., Solimena, M. and Weigert, M.
Nature Protocols 19
(5): 1436-1466.
May 2024
RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
Bahry, E., Breimann, L., Zouinkhi, M., Epstein, L., Kolyvanov, K., Mamrak, N., King, B., Long, Xi, Harrington, K.I.S., Lionnet, T. and Preibisch, S.
Nature Methods 19
(12): 1563-1567.
December 2022
Schmidt-Ott, Kai
Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E., Landthaler, M., Jung, K. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 35
(7): 838-853.
July 2024
Insm1 regulates mTEC development and immune tolerance.
Tao, W., Ye, Z., Wei, Y., Wang, J., Yang, W., Yu, G., Xiong, J. and Jia, S.
Cellular and Molecular Immunology 20
(12): 1472-1486.
December 2023
Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury.
Sieckmann, T., Schley, G., Ögel, N., Kelterborn, S., Boivin, F.J., Fähling, M., Ashraf, M.I., Reichel, M., Vigolo, E., Hartner, A., Lichtenberger, F.B., Breiderhoff, T., Knauf, F., Rosenberger, C., Aigner, F., Schmidt-Ott, K., Scholz, H. and Kirschner, K.M.
Kidney International 104
(1): 90-107.
July 2023
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60
(6): 2102725.
1 December 2022
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J., Kim, S.J., Skopnik, C.M., Hinze, C., Boltengagen, A., Metzke, D., Grothgar, E., Prskalo, L., Wagner, L., Freund, P., Görlich, N., Muench, F., Schmidt-Ott, K.M., Mashreghi, M.F., Kocks, C., Eckardt, K.U., Rajewsky, N. and Enghard, P.
Kidney International 102
(6): 1359-1370.
December 2022
Acute kidney injury in patients receiving pembrolizumab combination therapy versus pembrolizumab monotherapy for advanced lung cancer.
Gupta, S., Strohbehn, I.A., Wang, Q., Hanna, P.E., Seethapathy, R., Prosek, J.M., Herrmann, S.M., Abudayyeh, A., Malik, A.B., Loew, S., Carlos, C.A., Chang, W.T., Beckerman, P., Mithani, Z., Shah, C.V., Renaghan, A., de Seigneux, S., Campedel, L., Kitchlu, A., Shin, D.S., Coppock, G., Lumlertgul, N., Garcia, P., Ortiz-Melo, D.I., Rashidi, A., Sprangers, B., Aggarwal, V., Benesova, K., Jhaveri, K.D., Cortazar, F.B., Weins, A., Zuo, Y., Mooradian, M.J., Reynolds, K.L., Leaf, D.E. and Sise, M.E.
Kidney International 102
(4): 930-935.
October 2022
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14
(1): 103.
9 September 2022
Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta, S., Short, S.A.P., Sise, M.E., Prosek, J.M., Madhavan, S.M., Soler, M.J., Ostermann, M., Herrmann, S.M., Abudayyeh, A., Anand, S., Glezerman, I., Motwani, S.S., Murakami, N., Wanchoo, R., Ortiz-Melo, D.I., Rashidi, A., Sprangers, B., Aggarwal, V., Malik, A.B., Loew, S., Carlos, C.A., Chang, W.T., Beckerman, P., Mithani, Z., Shah, C.V., Renaghan, A.D., Seigneux, S.D., Campedel, L., Kitchlu, A., Shin, D.S., Rangarajan, S., Deshpande, P., Coppock, G., Eijgelsheim, M., Seethapathy, H., Lee, M.D., Strohbehn, I.A., Owen, D.H., Husain, M., Garcia-Carro, C., Bermejo, S., Lumlertgul, N., Seylanova, N., Flanders, L., Isik, B., Mamlouk, O., Lin, J.S., Garcia, P., Kaghazchi, A., Khanin, Y., Kansal, S.K., Wauters, E., Chandra, S., Schmidt-Ott, K.M., Hsu, R.K., Tio, M.C., Sarvode Mothi, S., Singh, H., Schrag, D., Jhaveri, K.D., Reynolds, K.L., Cortazar, F.B. and Leaf, D.E.
Journal for ImmunoTherapy of Cancer 9
(10): e003467.
October 2021
Long-term effects of COVID-19 on kidney function.
Enghard, P., Hardenberg, J.H., Stockmann, H., Hinze, C., Eckardt, K.U. and Schmidt-Ott, K.M.
Lancet 397
(10287): 1806-1807.
15 May 2021
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection.
Scholz, H., Boivin, F.J., Schmidt-Ott, K.M., Bachmann, S., Eckardt, K.U., Scholl, U.I. and Persson, P.B.
Nature Reviews Nephrology 17
(5): 335-349.
May 2021
High rates of long-term renal recovery in survivors of coronavirus disease 2019-associated acute kidney injury requiring kidney replacement therapy.
Stockmann, H., Hardenberg, J.H.B., Aigner, A., Hinze, C., Gotthardt, I., Stier, B., Eckardt, K.U., Schmidt-Ott, K.M. and Enghard, P.
Kidney International 99
(4): 1021-1022.
April 2021
Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C., Karaiskos, N., Boltengagen, A., Walentin, K., Redo, K., Himmerkus, N., Bleich, M., Potter, S.S., Potter, A.S., Eckardt, K.U., Kocks, C., Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32
(2): 291-306.
February 2021
Mix for regeneration: nephron replacement by transplanted cells.
Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 31
(12): 2743-2745.
December 2020
Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31
(7): 1569-1584.
July 2020
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q., Roske, Y., Schuetz, A., Walentin, K., Ibraimi, I., Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46
(4): 2082-2095.
28 February 2018
Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F., Gasparoni, N., Gasparoni, G., Gianmoena, K., Cadenas, C., Polansky, J.K., Ebert, P., Nordstroem, K., Barann, M., Sinha, A., Froehler, S., Xiong, J., Dehghani Amirabad, A., Behjati Ardakani, F., Hutter, B., Zipprich, G., Felder, B., Eils, J., Brors, B., Chen, W., Hengstler, J.G., Hamann, A., Lengauer, T., Rosenstiel, P., Walter, J. and Schulz, M.H.
Nucleic Acids Research 45
(1): 54-66.
9 January 2017
Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glažar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A.., Ardakani, F.B., Feuerbach, L., Gorka, O., Ebert, P., Müller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Fröhler, S., Felder, B., Gasparoni, N., Imbusch, C.D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A.S., Sieverling, L., Chang, H.D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.R., Rosenstiel, P., Schulz, M.H., Schultze, J.L., Radbruch, A., Walter, J., Hamann, A. and Polansky, J.K.
Immunity 45
(5): 1148-1161.
15 November 2016
α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N., Kulkarni, R., Werth, M., Schmidt-Ott, K.M., Forster, C., Deng, R., Zhang, Q., Singer, E., Klose, A.D., Shen, T.H., Francis, K.P., Ray, S., Vijayakumar, S., Seward, S., Bovino, M.E., Xu, K., Takabe, Y., Amaral, F.E., Mohan, S., Wax, R., Corbin, K., Sanna-Cherchi, S., Mori, K., Johnson, L., Nickolas, T., D’Agati, V., Lin, C.S., Qiu, A., Al-Awqati, Q., Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124
(7): 2963-2976.
1 July 2014
Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
Nickolas, T.L., Schmidt-Ott, K.M., Canetta, P., Forster, C., Singer, E., Sise, M., Elger, A., Maarouf, O., Sola-Del Valle, D.A., O'Rourke, M., Sherman, E., Lee, P., Geara, A., Imus, P., Guddati, A., Polland, A., Rahman, W., Elitok, S., Malik, N., Giglio, J., El-Sayegh, S., Devarajan, P., Hebbar, S., Saggi, S.J., Hahn, B., Kettritz, R., Luft, F.C. and Barasch, J.
Journal of the American College of Cardiology 59
(3): 246-255.
17 January 2012
The Ngal reporter mouse detects the response of the kidney to injury in real time.
Paragas, N., Qiu, A., Zhang, Q., Samstein, B., Deng, S.X., Schmidt-Ott, K.M., Viltard, M., Yu, W., Forster, C.S., Gong, G., Liu, Y., Kulkarni, R., Mori, K., Kalandadze, A., Ratner, A.J., Devarajan, P., Landry, D.W., D'Agati, V., Lin, C.S. and Barasch, J.
Nature Medicine 17
(2): 216-222.
February 2011
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao, G., Clifton, M., Hoette, T.M., Mori, K., Deng, S.X., Qiu, A., Viltard, M., Williams, D., Paragas, N., Leete, T., Kulkarni, R., Li, X., Lee, B., Kalandadze, A., Ratner, A.J., Pizarro, J.C., Schmidt-Ott, K.M., Landry, D.W., Raymond, K.N., Strong, R.K. and Barasch, J.
Nature Chemical Biology 6
(8): 602-609.
August 2010
Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Li, J.Y., Paragas, N., Ned, R.M., Qiu, A., Viltard, M., Leete, T., Drexler, I.R., Chen, X., Sanna-Cherchi, S., Mohammed, F., Williams, D., Lin, C.S., Schmidt-Ott, K.M., Andrews, N.C. and Barasch, J.
Developmental Cell 16
(1): 35-46.
20 January 2009
Schmitt, Clemens
Cellular senescence: Neither irreversible nor reversible.
Reimann, M., Lee, S. and Schmitt, C.A.
Journal of Experimental Medicine 221
(4): e20232136.
1 April 2024
Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14
(3): 492-507.
1 March 2024
Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine - a prospective cohort study by the AGMT.
Pleyer, L., Vaisband, M., Drost, M., Pfeilstöcker, M., Stauder, R., Heibl, S., Sill, H., Girschikofsky, M., Stampfl-Mattersberger, M., Pichler, A., Hartmann, B., Petzer, A., Schreder, M., Schmitt, C.A., Vallet, S., Melchardt, T., Zebisch, A., Pichler, P., Zaborsky, N., Machherndl-Spandl, S., Wolf, D., Keil, F., Hasenauer, J., Larcher-Senn, J. and Greil, R.
American Journal of Hematology 98
(11): 1685-1698.
November 2023
Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.
Bonifacius, A., Lamottke, B., Tischer-Zimmermann, S., Schultze-Florey, R., Goudeva, L., Heuft, H.G., Arseniev, L., Beier, R., Beutel, G., Cario, G., Fröhlich, B., Greil, J., Hansmann, L., Hasenkamp, J., Höfs, M., Hundsdoerfer, P., Jost, E., Kafa, K., Kriege, O., Kröger, N., Mathas, S., Meisel, R., Nathrath, M., Putkonen, M., Ravens, S., Reinhardt, H.C., Sala, E., Sauer, M.G, Schmitt, C., Schroers, R., Steckel, N.K., Trappe, R.U., Verbeek, M., Wolff, D., Blasczyk, R., Eiz-Vesper, B. and Maecker-Kolhoff, B.
Journal of Clinical Investigation 133
(12): e163548.
15 June 2023
COVID-19 and cellular senescence.
Schmitt, C.A., Tchkonia, T., Niedernhofer, L.J., Robbins, P.D., Kirkland, J.L. and Lee, S.
Nature Reviews Immunology 23
(4): 251-263.
April 2023
A cFLIP-flop switch for senolysis.
Fan, D.N.Y. and Schmitt, C.A.
Nature Cancer 3
(11): 1279-1281.
November 2022
Senescence and cancer - role and therapeutic opportunities.
Schmitt, C.A., Wang, B. and Demaria, M.
Nature Reviews Clinical oncology 19
(10): 619–636.
October 2022
The genomic and transcriptional landscape of primary central nervous system lymphoma.
Radke, J., Ishaque, N., Koll, R., Gu, Z., Schumann, E., Sieverling, L., Uhrig, S., Hübschmann, D., Toprak, U.H., López, C., Hostench, X.P., Borgoni, S., Juraeva, D., Pritsch, F., Paramasivam, N., Balasubramanian, G.P., Schlesner, M., Sahay, S., Weniger, M., Pehl, D., Radbruch, H., Osterloh, A., Korfel, A., Misch, M., Onken, J., Faust, K., Vajkoczy, P., Moskopp, D., Wang, Y., Jödicke, A., Trümper, L., Anagnostopoulos, I., Lenze, D., Küppers, R., Hummel, M., Schmitt, C.A., Wiestler, O.D., Wolf, S., Unterberg, A., Eils, R., Herold-Mende, C., Brors, B., Siebert, R., Wiemann, S. and Heppner, F.L.
Nature Communications 13
(1): 2558.
10 May 2022
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke, A.C., Doebele, C., Zindel, A., Lee, K.S., Rieke, S.A., Ceribelli, M., Comoglio, F., Phelan, J.D., Wang, J.Q., Pikman, Y., Jahn, D., Häupl, B., Schneider, C., Scheich, S., Tosto, F.A., Bohnenberger, H., Stauder, P., Schnütgen, F., Slabicki, M., Coulibaly, Z.A., Wolf, S., Bojarczuk, K., Chapuy, B., Brandts, C.H., Stroebel, P., Lewis, C.A., Engelke, M., Xu, X., Kim, H., Dang, T.H., Schmitz, R., Hodson, D.J., Stegmaier, K., Urlaub, H., Serve, H., Schmitt, C.A., Kreuz, F., Knittel, G., Rabinowitz, J.D., Reinhardt, H.C., Vander Heiden, M.G., Thomas, C., Staudt, L.M., Zenz, T. and Oellerich, T.
Blood 139
(4): 538-553.
27 January 2022
Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C., Dietert, K., Schotsaert, M., Martínez-Romero, C., Singh, G., Kunz, S., Niemeyer, D., Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M., Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S., Gruber, A.D., Hoetzenecker, W., Steinkellner, H., Purfuerst, B., Motz, R., Di Pierro, F., Lamprecht, B., Osterrieder, N., Landthaler, M., Drosten, C., García-Sastre, A., Langer, R., Ralser, M., Eils, R., Reimann, M., Fan, D.N.Y. and Schmitt, C.A.
Nature 599
: 283-289.
11 November 2021
Therapy-induced senescence: opportunities to improve anticancer therapy.
Prasanna, P.G., Citrin, D.E., Hildesheim, J., Ahmed, M.M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J., Kron, S.J., Anscher, M.S., Sharpless, N.E., Campisi, J., Brown, S.L., Niedernhofer, L.J., O'Loghlen, A., Georgakilas, A.G., Paris, F., Gius, D., Gewirtz, D.A., Schmitt, C.A., Abazeed, M.E., Kirkland, J.L., Richmond, A., Romesser, P.B., Lowe, S.W., Gil, J., Mendonca, M.S., Burma, S., Zhou, D. and Coleman, C.N.
Journal of the National Cancer Institute 113
(10): 1285-1298.
October 2021
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann, J., Lorenz, C., Borchmann, S., Nishii, K., Wegner, J., Meder, L., Ostendorp, J., Ast, D.F., Heimsoeth, A., Nakasuka, T., Hirabae, A., Okawa, S., Dammert, M.A., Plenker, D., Klein, S., Lohneis, P., Gu, J., Godfrey, L.K., Forster, J., Trajkovic-Arsic, M., Zillinger, T., Haarmann, M., Quaas, A., Lennartz, S., Schmiel, M., D'Rozario, J., Thomas, E.S., Li, H., Schmitt, C.A., George, J., Thomas, R.K., von Karstedt, S., Hartmann, G., Büttner, R., Ullrich, R.T., Siveke, J.T., Ohashi, K., Schlee, M. and Sos, M.L.
Nature Communications 12
(1): 5505.
17 September 2021
Humoral and cellular immune responses in SARS-CoV-2 mRNA-vaccinated patients with cancer.
Mairhofer, M., Kausche, L., Kaltenbrunner, S., Ghanem, R., Stegemann, M., Klein, K., Pammer, M., Rauscher, I., Salzer, H.J.F., Doppler, S., Habringer, A., Paar, C., Kimeswenger, S., Hoetzenecker, W., Lamprecht, B., Lee, S. and Schmitt, C.A.
Cancer Cell 39
(9): 1171-1172.
13 September 2021
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann, M., Schrezenmeier, J.F., Richter-Pechanska, P., Dolnik, A., Hick, T.P., Schleich, K., Cai, X., Fan, D.N.Y., Lohneis, P., Masswig, S., Denker, S., Busse, A., Knittel, G., Flümann, R., Childs, D., Childs, L., Gätjens-Sanchez, A.M., Bullinger, L., Rosenwald, A., Reinhardt, H.C. and Schmitt, C.A.
Blood 137
(20): 2785-2899.
20 May 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K., Kase, J., Dörr, J.R., Trescher, S., Bhattacharya, A., Yu, Y., Wailes, E.M., Fan, D.N.Y., Lohneis, P., Milanovic, M., Lau, A., Lenze, D., Hummel, M., Chapuy, B., Leser, U., Reimann, M., Lee, S. and Schmitt, C.A.
Nature Communications 11
(1): 3651.
20 July 2020
AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R.I., Roux, P.F., de Freitas, J.A.N.L.F., Robinson, L., Doré, G., Sun, B., Belenki, D., Milanovic, M., Herbig, U., Schmitt, C.A., Gil, J. and Bischof, O.
Nature Cell Biology 22
(7): 842-855.
July 2020
Cellular senescence: defining a path forward.
Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D.C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A.B., Narita, M., Niedernhofer, L., Passos, J.F., Robbins, P.D., Schmitt, C.A., Sedivy, J., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M. and Demaria, M.
Cell 179
(4): 813-827.
31 October 2019
The dynamic nature of senescence in cancer.
Lee, S. and Schmitt, C.A.
Nature Cell Biology 21
(1): 94-101.
January 2019
The Senescence-Stemness Alliance - a cancer-hijacked regeneration principle.
Milanovic, M., Yu, Y. and Schmitt, C.A.
Trends in Cell Biology 28
(12): 1049-1061.
December 2018
UnSASPing senescence: unmasking tumor suppression?
Schmitt, C.A.
Cancer Cell 34
(1): 6-8.
9 July 2018
Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M.S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dörken, B., Speck, C., Mallette, F.A., Zon, L.I., Holmen, S.L., Peeper, D.S., Samuels, Y., Schmitt, C.A. and Lee, S.
Cancer Cell 33
(2): 322-336.
12 February 2018
Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M., Fan, D.N.Y., Belenki, D., Däbritz, J.H.M., Zhao, Z., Yu, Y., Dörr, J.R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G., Lee, S. and Schmitt, C.A.
Nature 553
(7686): 96-100.
4 January 2018
EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.
Young, E., Noerenberg, D., Mansouri, L., Ljungström, V., Frick, M., Sutton, L.A., Blakemore, S.J., Galan-Sousa, J., Plevova, K., Baliakas, P., Rossi, D., Clifford, R., Roos-Weil, D., Navrkalova, V., Dörken, B., Schmitt, C.A., Smedby, K.E., Juliusson, G., Giacopelli, B., Blachly, J.S., Belessi, C., Panagiotidis, P., Chiorazzi, N., Davi, F., Langerak, A.W., Oscier, D., Schuh, A., Gaidano, G., Ghia, P., Xu, W., Fan, L., Bernard, O.A., Nguyen-Khac, F., Rassenti, L., Li, J., Kipps, T.J., Stamatopoulos, K., Pospisilova, S., Zenz, T., Oakes, C.C., Strefford, J.C., Rosenquist, R. and Damm, F.
Leukemia 31
(7): 1547-1554.
July 2017
Initiation of acute graft-versus-host disease by angiogenesis.
Riesner, K., Shi, Y., Jacobi, A., Kräter, M., Kalupa, M., McGearey, A., Mertlitz, S., Cordes, S., Schrezenmeier, J.F., Mengwasser, J., Westphal, S., Perez-Hernandez, D., Schmitt, C., Dittmar, G., Guck, J. and Penack, O.
Blood 129
(14): 2021-2032.
6 April 2017
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J., Neuenschwander, M., Yu, Y., Däbritz, J.H.M., Neuendorff, N.R., Schleich, K., Bittner, A., Milanovic, M., Beuster, G., Radetzki, S., Specker, E., Reimann, M., Rosenbauer, F., Mathas, S., Lohneis, P., Hummel, M., Dörken, B., von Kries, J.P., Lee, S. and Schmitt, C.A.
Blood 129
(1): 71-81.
5 January 2017
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J., Yu, Y., Akilli Öztürk, Ö., Holland, J.D., Besser, D., Fritzmann, J., Wulf-Goldenberg, A., Eckert, K., Fichtner, I. and Birchmeier, W.
Gut 65
(10): 1690-1701.
October 2016
The persistent dynamic secrets of senescence.
Schmitt, C.A.
Nature Cell Biology 18
(9): 913-915.
September 2016
B cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B cell lymphoma in mice.
Knittel, G., Liedgens, P., Korovkina, D., Seeger, J.M., Al-Baldawi, Y., Al-Maarri, M., Fritz, C., Vlantis, K., Bezhanova, S., Scheel, A.H., Wolz, O.O., Reimann, M., Möller, P., López, C., Schlesner, M., Lohneis, P., Weber, A.N.R., Trümper, L., Staudt, L.M., Ortmann, M., Pasparakis, M., Siebert, R., Schmitt, C.A., Klatt, A.R., Wunderlich, F.T., Schäfer, S.C., Persigehl, T., Montesinos-Rongen, M., Odenthal, M., Büttner, R., Frenzel, L.P., Kashkar, H. and Reinhardt, H.C.
Blood 127
(22): 2732-2741.
2 June 2016
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501
(7467): 421-425.
19 September 2013
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Bywater, M.J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C., Wall, M., Cluse, L., Drygin, D., Anderes, K., Huser, N., Proffitt, C., Bliesath, J., Haddach, M., Schwaebe, M.K., Ryckman, D.M., Rice, W.G., Schmitt, C., Lowe, S.W., Johnstone, R.W., Pearson, R.B., McArthur, G.A. and Hannan, R.D.
Cancer Cell 22
(1): 51-65.
10 July 2012
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Doerken, B., Lenz, G., Scheidereit, C., Schmitt, C.A. and Lee, S.
Genes & Development 25
(20): 2137-2146.
15 October 2011
Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J.R., Tabor, V., Aichele, P., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17
(3): 262-272.
16 March 2010
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Bouchard, C., Lee, S., Paulus-Hock, V., Loddenkemper, C., Eilers, M. and Schmitt, C.A.
Genes & Development 21
(21): 2775-2787.
1 November 2007
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann, M., Loddenkemper, C., Rudolph, C., Schildhauer, I., Teichmann, B., Stein, H., Schlegelberger, B., Doerken, B. and Schmitt, C.A.
Blood 110
(8): 2996-3004.
15 October 2007
Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A.H., Schlegelberger, B., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Nature 436
(7051): 660-665.
4 August 2005
Cellular senescence in cancer treatment: friend or foe?
Kahlem, P., Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113
(2): 169-174.
January 2004
Senescence apoptosis and therapy - cutting the lifelines of cancer.
Schmitt, C.A.
Nature Reviews Cancer 3
(4): 286-295.
April 2003
Chemotherapy response and resistance.
Lee, S. and Schmitt, C.A.
Current Opinion in Genetics & Development 13
(1): 90-96.
February 2003
Schmitz, Dietmar
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.
Wietek, J., Nozownik, A., Pulin, M., Saraf-Sinik, I., Matosevich, N., Gowrishankar, R., Gat, A., Malan, D., Brown, B.J., Dine, J., Imambocus, B.N., Levy, R., Sauter, K., Litvin, A., Regev, N., Subramaniam, S., Abrera, K., Summarli, D., Goren, E.M., Mizrachi, G., Bitton, E., Benjamin, A., Copits, B.A., Sasse, P., Rost, B.R., Schmitz, D., Bruchas, M.R., Soba, P., Oren-Suissa, M., Nir, Y., Wiegert, J.S. and Yizhar, O.
Nature Methods 21
(7): 1275-1287.
July 2024
Genetic identification of medullary neurons underlying congenital hypoventilation.
Cui, K., Xia, Y., Patnaik, A., Salivara, A., Lowenstein, E.D., Isik, E.G., Knorz, A.L., Airaghi, L., Crotti, M., Garratt, A.N., Meng, F., Schmitz, D., Studer, M., Rijli, F.M., Nothwang, H.G., Rost, B.R., Strauß, U. and Hernandez-Miranda, L.R.
Science Advances 10
(25): eadj0720.
21 June 2024
Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit.
Peng, Y., Bjelde, A., Aceituno, P.V., Mittermaier, F.X., Planert, H., Grosser, S., Onken, J., Faust, K., Kalbhenn, T., Simon, M., Radbruch, H., Fidzinski, P., Schmitz, D., Alle, H., Holtkamp, M., Vida, I., Grewe, B.F. and Geiger, J.R.P.
Science 384
(6693): 338-343.
26 April 2024
Gamma oscillation plasticity is mediated via parvalbumin interneurons.
Hadler, M.D., Tzilivaki, A., Schmitz, D., Alle, H. and Geiger, J.R.P.
Science Advances 10
(5): eadj7427.
2 February 2024
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14
(1): 8043.
19 December 2023
Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
Reincke, S.M., von Wardenburg, N., Homeyer, M.A., Kornau, H.C., Spagni, G., Li, L.Y., Kreye, J., Sánchez-Sendín, E., Blumenau, S., Stappert, D., Radbruch, H., Hauser, A.E., Künkele, A., Edes, I., Schmitz, D. and Prüss, H.
Cell 186
(23): 5084-5097.e18.
9 November 2023
Hippocampal GABAergic interneurons and memory.
Tzilivaki, A., Tukker, J.J., Maier, N., Poirazi, P., Sammons, R.P. and Schmitz, D.
Neuron 111
(20): 3154-3175.
18 October 2023
Play and tickling responses map to the lateral columns of the rat periaqueductal gray.
Gloveli, N., Simonnet, J., Tang, W., Concha-Miranda, M., Maier, E., Dvorzhak, A., Schmitz, D. and Brecht, M.
Neuron 111
(19): 3041-3052.
4 October 2023
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.
Fernandez Lahore, R.G., Pampaloni, N.P., Schiewer, E., Heim, M.M., Tillert, L., Vierock, J., Oppermann, J., Walther, J., Schmitz, D., Owald, D., Plested, A.J.R., Rost, B.R. and Hegemann, P.
Nature Communications 13
(1): 7844.
21 December 2022
Optogenetics at the presynapse.
Rost, B.R., Wietek, J., Yizhar, O. and Schmitz, D.
Nature Neuroscience 25
(8): 984-998.
August 2022
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
Hesse, J., Schleimer, J.H., Maier, N., Schmitz, D. and Schreiber, S.
Nature Communications 13
(1): 3934.
8 July 2022
Interneuron switching on and off across memory rhythms.
Tzilivaki, A., Maier, N. and Schmitz, D.
Neuron 110
(12): 1884-1886.
15 June 2022
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial.
Schwarz, C., Benson, G.S., Horn, N., Wurdack, K., Grittner, U., Schilling, R., Märschenz, S., Köbe, T., Hofer, S.J., Magnes, C., Stekovic, S., Eisenberg, T., Sigrist, S.J., Schmitz, D., Wirth, M., Madeo, F. and Flöel, A.
JAMA Network Open 5
(5): e2213875.
26 May 2022
Brain-wide interactions during hippocampal sharp wave ripples.
Nitzan, N., Swanson, R., Schmitz, D. and Buzsáki, G.
Proceedings of the National Academy of Sciences of the United States of America 119
(20): e2200931119.
17 May 2022
Microcircuits for spatial coding in the medial entorhinal cortex.
Tukker, J.J., Beed, P., Brecht, M., Kempter, R., Moser, E.I. and Schmitz, D.
Physiological Reviews 102
(2): 653-688.
1 April 2022
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Reincke, S.M., Yuan, M., Kornau, H.C., Corman, V.M., van Hoof, S., Sánchez-Sendin, E., Ramberger, M., Yu, W., Hua, Y., Tien, H., Schmidt, M.L., Schwarz, T., Jeworowski, L.M., Brandl, S.E., Rasmussen, H.F., Homeyer, M.A., Stöffler, L., Barner, M., Kunkel, D., Huo, S., Horler, J., von Wardenburg, N., Kroidl, I., Eser, T.M., Wieser, A., Geldmacher, C., Hoelscher, M., Gänzer, H., Weiss, G., Schmitz, D., Drosten, C., Prüss, H., Wilson, I.A. and Kreye, J.
Science 375
(6582): 782-787.
18 February 2022
Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures.
Kreye, J., Wright, S.K., van Casteren, A., Stoeffler, L., Machule, M.L., Reincke, S.M., Nikolaus, M., van Hoof, S., Sanchez-Sendin, E., Homeyer, M.A., Gómez, C.C., Kornau, H.C., Schmitz, D., Kaindl, A.M., Boehm-Sturm, P., Mueller, S., Wilson, M.A., Upadhya, M.A., Dhangar, D.R., Greenhill, S., Woodhall, G., Turko, P., Vida, I., Garner, C.C., Wickel, J., Geis, C., Fukata, Y., Fukata, M. and Prüss, H.
Journal of Experimental Medicine 218
(11): e20210012.
1 November 2021
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin.
Mahn, M., Saraf-Sinik, I., Patil, P., Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S. and Yizhar, O.
Neuron 109
(10): 1621-1635.
19 May 2021
Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum.
Kuijpers, M., Kochlamazashvili, G., Stumpf, A., Puchkov, D., Swaminathan, A., Lucht, M.T., Krause, E., Maritzen, T., Schmitz, D. and Haucke, V.
Neuron 109
(2): 299-313.
20 January 2021
A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Rodríguez de los Santos, M., Rivalan, M., David, F.S., Stumpf, A., Pitsch, J., Tsortouktzidis, D., Velasquez, L.M., Voigt, A., Schilling, K., Mattei, D., Long, M., Vogt, G., Knaus, A., Fischer-Zirnsak, B., Wittler, L., Timmermann, B., Robinson, P.N., Horn, D., Mundlos, S., Kornak, U., Becker, A.J., Schmitz, D., Winter, Y. and Krawitz, P.M.
Proceedings of the National Academy of Sciences of the United States of America 118
(2): e2014481118.
12 January 2021
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Kreye, J., Reincke, S.M., Kornau, H.C., Sánchez-Sendin, E., Corman, V.M., Liu, H., Yuan, M., Wu, N.C., Zhu, X., Lee, C.C.D., Trimpert, J., Höltje, M., Dietert, K., Stöffler, L., von Wardenburg, N., van Hoof, S., Homeyer, M.A., Hoffmann, J., Abdelgawad, A., Gruber, A.D., Bertzbach, L.D., Vladimirova, D., Li, L.Y., Barthel, P.C., Skriner, K., Hocke, A.C., Hippenstiel, S., Witzenrath, M., Suttorp, N., Kurth, F., Franke, C., Endres, M., Schmitz, D., Jeworowski, L.M., Richter, A., Schmidt, M.L., Schwarz, T., Müller, M.A., Drosten, C., Wendisch, D., Sander, L.E., Osterrieder, N., Wilson, I.A. and Prüss, H.
Cell 183
(4): 1058-1069.
12 November 2020
Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N., McKenzie, S., Beed, P., English, D.F., Oldani, S., Tukker, J.J., Buzsáki, G. and Schmitz, D.
Nature Communications 11
(1): 1947.
23 April 2020
Human cerebrospinal fluid monoclonal LGI1 autoantibodies increase neuronal excitability.
Kornau, H.C., Kreye, J., Stumpf, A., Fukata, Y., Parthier, D., Sammons, R.P., Imbrosci, B., Kurpjuweit, S., Kowski, A.B., Fukata, M., Prüss, H. and Schmitz, D.
Annals of Neurology 87
(3): 405-418.
March 2020
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10
(1): 217.
15 January 2019
Potassium channel-based optogenetic silencing.
Bernal Sierra, Y.A., Rost, B.R., Pofahl, M., Fernandes, A.M., Kopton, R.A., Moser, S., Holtkamp, D., Masala, N., Beed, P., Tukker, J.J., Oldani, S., Bönigk, W., Kohl, P., Baier, H., Schneider-Warme, F., Hegemann, P., Beck, H., Seifert, R. and Schmitz, D.
Nature Communications 9
(1): 4611.
5 November 2018
Optogenetic tools for subcellular applications in neuroscience.
Rost, B.R., Schneider-Warme, F., Schmitz, D. and Hegemann, Peter
Neuron 96
(3): 572-603.
1 November 2017
Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye, J., Wenke, N.K., Chayka, M., Leubner, J., Murugan, R., Maier, N., Jurek, B., Ly, L.T., Brandl, D., Rost, B.R., Stumpf, A., Schulz, P., Radbruch, H., Hauser, A.E., Pache, F., Meisel, A., Harms, L., Paul, F., Dirnagl, U., Garner, C., Schmitz, D., Wardemann, H. and Prüss, H.
Brain 139
(10): 2641-2652.
1 October 2016
Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus.
Stempel, A.V., Stumpf, A., Zhang, H.Y., Özdoğan, T., Pannasch, U., Theis, A.K., Otte, D.M., Wojtalla, A., Racz, I., Ponomarenko, A., Xi, Z.X., Zimmer, A. and Schmitz, D.
Neuron 90
(4): 795-809.
18 May 2016
Cellular and system biology of memory: Timing, molecules, and beyond.
Korte, M. and Schmitz, D.
Physiological Reviews 96
(2): 647-693.
April 2016
Optogenetic acidification of synaptic vesicles and lysosomes.
Rost, B.R., Schneider, F., Grauel, M.K., Wozny, C., Bentz, C.G., Blessing, A., Rosenmund, T., Jentsch, T.J., Schmitz, D., Hegemann, P. and Rosenmund, C.
Nature Neuroscience 18
(12): 1845-1852.
December 2015
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P., Korotkova, T., Heidenreich, M., Maier, N., Schuetze, S., Kobler, O., Zuschratter, W., Schmitz, D., Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6
: 6254.
4 February 2015
Retrograde signaling causes excitement.
Schmitz, D., Breustedt, J. and Gundlfinger, A.
Neuron 81
(4): 717-719.
19 February 2014
Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.
Beed, P., Gundlfinger, A., Schneiderbauer, S., Song, J., Boehm, C., Burgalossi, A., Brecht, M., Vida, I. and Schmitz, D.
Neuron 79
(6): 1197-1207.
18 September 2013
Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.
Kintscher, M., Wozny, C., Johenning, F.W., Schmitz, D. and Breustedt, J.
Nature Communications 4
: 2392.
3 September 2013
Coherent phasic excitation during hippocampal ripples.
Maier, N., Tejero-Cantero, A., Dorrn, A.L., Winterer, J., Beed, P.S., Morris, G., Kempter, R., Poulet, J.F.A., Leibold, C. and Schmitz, D.
Neuron 72
(1): 137-152.
6 October 2011
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T., Beed, P., Vogt, J., Schuchmann, S., Maier, N., Kintscher, M., Breustedt, J., Schuelke, M., Streu, N., Kieselmann, O., Brunk, I., Laube, G., Strauss, U., Battefeld, A., Wende, H., Birchmeier, C., Wiese, S., Sendtner, M., Kawabe, H., Kishimoto-Suga, M., Brose, N., Baumgart, J., Geist, B., Aoki, J., Savaskan, N.E., Braeuer, A.U., Chun, J., Ninnemann, O., Schmitz, D. and Nitsch, R.
Cell 138
(6): 1222-12235.
18 September 2009
Schreiber, Adrian (ECRC)
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83
(4): 499-507.
12 March 2024
Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132
(23): e160089.
1 December 2022
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A., Sonnemann, J., Amann, K., Mildner, A., Lodka, D., Kling, L., Bieringer, M., Schneider, U., Leutz, A., Enghard, P., Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81
(8): 1162-1172.
August 2022
Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31
(7): 1569-1584.
July 2020
Schroeder, Bjoern Christian
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C., Seniuk, A., Sokolov, M.V., Huebner, A.K., Klementowicz, A.E., Szijártó, I.A., Schleifenbaum, J., Vitzthum, H., Gollasch, M., Ehmke, H., Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124
(2): 675-686.
3 February 2014
Schuetz, Anja
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24
(3): 414-422.
March 2023
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q., Roske, Y., Schuetz, A., Walentin, K., Ibraimi, I., Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46
(4): 2082-2095.
28 February 2018
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M. and Heinemann, U.
Nature Communications 5
: 5701.
11 December 2014
Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A., Wagner, S., Ortwein, J., Kim, B.G., Lisurek, M., Beligny, S., Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51
(37): 9441-9447.
10 September 2012
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T. and Jarosch, E.
Molecular Cell 36
(5): 782-793.
11 December 2009
Protein production and purification.
Gräslund, S., Nordlund, P., Weigelt, J., Hallberg, M., Bray, J., Gileadi, O., Knapp, S., Oppermann, U., Arrowsmith, C., Hui, R., Ming, J., dhe-Paganon, S., Park, H.W., Savchenko, A., Yee, A., Edwards, A., Vincentelli, R., Cambillau, C., Kim, R., Kim, S.H., Rao, Z., Shi, Y., Terwilliger, T.C., Kim, C.Y., Hung, L.W., Waldo, G.S., Peleg, Y., Albeck, S., Unger, T., Dym, O., Prilusky, J., Sussman, J.L., Stevens, R.C., Lesley, S.A., Wilson, I.A., Joachimiak, A., Collart, F., Dementieva, I., Donnelly, M.I., Eschenfeldt, W.H., Kim, Y.M., Stols, L., Wu, R., Zhou, M., Burley, S.K., Emtage, J.S., Sauder, J.M., Thompson, D., Bain, K., Luz, J., Gheyi, T., Zhang, F., Atwell, S., Almo, S.C., Bonanno, J.B., Fiser, A., Swaminathan, S., Studier, F.W., Chance, M.R., Sali, A., Acton, T.B., Xiao, R., Zhao, L., Ma, L.C., Hunt, J.F., Tong, L., Cunningham, K., Inouye, M., Anderson, S., Janjua, H., Shastry, R., Ho, C.K., Wang, D., Wang, H., Jiang, M., Montelione, G.T., Stuart, D.I., Owens, R.J., Daenke, S., Schütz, A., Heinemann, U., Yokoyama, S., Büssow, K. and Gunsalus, K.C.
Nature Methods 5
(2): 135-146.
February 2008
Schulz-Menger, Jeanette (ECRC)
Stress CMR Perfusion Imaging in the Medicare-Eligible Population: Insights From the SPINS Study.
Ge, Y., Antiochos, P., Bernhard, B., Heydari, B., Steel, K., Bingham, S., Mikolich, J.R., Arai, A.E., Bandettini, W.P., Patel, A.R., Shanbhag, S.M., Farzaneh-Far, A., Heitner, J.F., Shenoy, C., Leung, S.W., Gonzalez, J.A., Shah, D.J., Raman, S.V., Ferrari, V.A., Schulz-Menger, J., Stuber, M., Simonetti, O.P. and Kwong, R.Y.
JACC: Cardiovascular Imaging
16 October 2024
(In Press)
Association of adverse clinical outcomes with peri-infarct ischemia detected by stress cardiac magnetic imaging.
Bernhard, B., Ge, Y., Antiochos, P., Heydari, B., Islam, S., Sanchez Santiuste, N., Steel, K.E., Bingham, S., Mikolich, J.R., Arai, A.E., Bandettini, W.P., Patel, A.R., Shanbhag, S.M., Farzaneh-Far, A., Heitner, J.F., Shenoy, C., Leung, S.W., Gonzalez, J.A., Raman, S.V., Ferrari, V.A., Shah, D.J., Schulz-Menger, J., Stuber, M., Simonetti, O.P. and Kwong, R.Y.
Journal of the American College of Cardiology 84
(5): 417-429.
30 July 2024
Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A., Wiesemann, S., Golic, M., Balogh, A., Marko, L., Rakova, N., Wilck, N., Blaszczyk, E., Lim, C., Weiss, S., Kräker, K., Haase, N., Frolova, A., Jørgensen, J.S., Daub, S., Mueller, D.N., Herse, F., Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13
(5): 1291-1293.
May 2020
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
Haufe, S., Engeli, S., Kast, P., Boehnke, J., Utz, W., Haas, V., Hermsdorf, M., Maehler, A., Wiesner, S., Birkenfeld, A.L., Sell, H., Otto, C., Mehling, H., Luft, F.C., Eckel, J., Schulz-Menger, J., Boschmann, M. and Jordan, J.
Hepatology 53
(5): 1504-1514.
May 2011
Effect of binge drinking on the heart as assessed by cardiac magnetic resonance imaging.
Zagrosek, A., Messroghli, D., Schulz, O., Dietz, R. and Schulz-Menger, J.
JAMA: Journal of the American Medical Association 304
(12): 1328-1330.
22 September 2010
Cardiac involvement in sporadic inclusion-body myositis.
Utz, W., Schmidt, S., Schulz-Menger, J., Luft, F. and Spuler, S.
Circulation 121
(5): 706-708.
9 February 2010
Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling.
Rudolph, A., Abdel-Aty, H., Bohl, S., Boye, P., Zagrosek, A., Dietz, R. and Schulz-Menger, J.
Journal of the American College of Cardiology 53
(3): 284-291.
20 January 2009
The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance.
Friedrich, M.G., Abdel-Aty, H., Taylor, A.J., Schulz-Menger, J., Messroghli, D. and Dietz, R.
Journal of the American College of Cardiology 51
(16): 1581-1587.
22 April 2008
Letter regarding article by Sharkey et al. "Acute and reversible cardiomyopathy provoked by stress in women from the United States".
Abdel-Aty, H., Dietz, R. and Schulz-Menger, J.
Circulation 112
: e51.
19 July 2005
Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction.
Abdel-Aty, H., Zagrosek, A., Schulz-Menger, J., Taylor, A.J., Messroghli, D., Kumar, A., Gross, M., Dietz, R. and Friedrich, M.G.
Circulation 109
(20): 2411-2416.
25 May 2004
Schwarz, Roland (BIMSB)
Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk.
de Biase, M.S., Massip, F., Wei, T.T., Giorgi, F.M., Stark, R., Stone, A., Gladwell, A., O'Reilly, M., Schütte, D., de Santiago, I., Meyer, K.B., Markowetz, F., Ponder, B.A.J., Rintoul, R.C. and Schwarz, R.F.
Genome Medicine 16
(1): 54.
8 April 2024
IL-33 expression is lower in current smokers at both transcriptomic and protein level.
Faiz, A., Mahbub, R.M., Boedijono, F.S., Tomassen, M.I., Kooistra, W., Timens, W., Nawijn, M., Hansbro, P.M., Johansen, M.D., Pouwels, S.D., Heijink, I.H., Massip, F., de Biase, M.S., Schwarz, R.F., Adcock, I.M., Chung, K.F., van der Does, A., Hiemstra, P.S., Goulaouic, H., Xing, H., Abdulai, R., de Rinaldis, E., Cunoosamy, D., Harel, S., Lederer, D., Nivens, M.C., Wark, P.A., Kerstjens, H.A.M., Hylkema, M.N., Brandsma, C.A. and van den Berge, M.
American Journal of Respiratory and Critical Care Medicine 208
(10): 1075-1087.
15 November 2023
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E., Planas-Fèlix, M., Burkert, M., Puiggròs, M., Toedling, J., Thiessen, N., Blanc, E., Szymansky, A., Hertwig, F., Ishaque, N., Beule, D., Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F., Haase, K., Schulte, J.H. and Henssen, A.G.
Cell Genomics 3
(10): 100402.
11 October 2023
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55
(5): 880-890.
May 2023
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Abbosh, C., Frankell, A.M., Harrison, T., Kisistok, J., Garnett, A., Johnson, L., Veeriah, S., Moreau, M., Chesh, A., Chaunzwa, T.L., Weiss, J., Schroeder, M.R., Ward, S., Grigoriadis, K., Shahpurwalla, A., Litchfield, K., Puttick, C., Biswas, D., Karasaki, T., Black, J.R.M., Martínez-Ruiz, C., Bakir, M.A.l., Pich, O., Watkins, T.B.K., Lim, E.L., Huebner, A., Moore, D.A., Godin-Heymann, N., L'Hernault, A., Bye, H., Odell, A., Roberts, P., Gomes, F., Patel, A.J., Manzano, E., Hiley, C.T., Carey, N., Riley, J., Cook, D.E., Hodgson, D., Stetson, D., Barrett, J.C., Kortlever, R.M., Evan, G.I., Hackshaw, A., Daber, R.D., Shaw, J.A., Aerts, H.J.W.L., Licon, A., Stahl, J., Jamal-Hanjani, M., Birkbak, N.J., McGranahan, N. and Swanton, C.
Nature 616
(7957): 553-562.
20 April 2023
The evolution of lung cancer and impact of subclonal selection in TRACERx.
Frankell, A.M., Dietzen, M., Al Bakir, M., Lim, E.L., Karasaki, T., Ward, S., Veeriah, S., Colliver, E., Huebner, A., Bunkum, A., Hill, M.S., Grigoriadis, K., Moore, D.A., Black, J.R.M., Liu, W.K., Thol, K., Pich, O., Watkins, T.B.K., Naceur-Lombardelli, C., Cook, D.E., Salgado, R., Wilson, G.A., Bailey, C., Angelova, M., Bentham, R., Martínez-Ruiz, C., Abbosh, C., Nicholson, A.G., Le Quesne, J., Biswas, D., Rosenthal, R., Puttick, C., Hessey, S., Lee, C., Prymas, P., Toncheva, A., Smith, J., Xing, W., Nicod, J., Price, G., Kerr, K.M., Naidu, B., Middleton, G., Blyth, K.G., Fennell, D.A., Forster, M.D., Lee, S.M., Falzon, M., Hewish, M., Shackcloth, M.J., Lim, E., Benafif, S., Russell, P., Boleti, E., Krebs, M.G., Lester, J.F., Papadatos-Pastos, D., Ahmad, T., Thakrar, R.M., Lawrence, D., Navani, N., Janes, S.M., Dive, C., Blackhall, F.H, Summers, Y., Cave, J., Marafioti, T., Herrero, J., Quezada, S.A., Peggs, K.S., Schwarz, R.F., Van Loo, P., Miedema, D.M., Birkbak, N.J., Hiley, C.T., Hackshaw, A., Zaccaria, S., Jamal-Hanjani, M., McGranahan, N. and Swanton, C.
Nature 616
(7957): 525-533.
20 April 2023
The evolution of non-small cell lung cancer metastases in TRACERx.
Al Bakir, M., Huebner, A., Martínez-Ruiz, C., Grigoriadis, K., Watkins, T.B.K., Pich, O., Moore, D.A., Veeriah, S., Ward, S., Laycock, J., Johnson, D., Rowan, A., Razaq, M., Akther, M., Naceur-Lombardelli, C., Prymas, P., Toncheva, A., Hessey, S., Dietzen, M., Colliver, E., Frankell, A.M., Bunkum, A., Lim, E.L., Karasaki, T., Abbosh, C., Hiley, C.T., Hill, M.S., Cook, D.E., Wilson, G.A., Salgado, R., Nye, E., Stone, R.K., Fennell, D.A., Price, G., Kerr, K.M., Naidu, B., Middleton, G., Summers, Y., Lindsay, C.R., Blackhall, F.H., Cave, J., Blyth, K.G., Nair, A., Ahmed, A., Taylor, M.N., Procter, A.J., Falzon, M., Lawrence, D., Navani, N., Thakrar, R.M., Janes, S.M., Papadatos-Pastos, D., Forster, M.D., Lee, S.M., Ahmad, T., Quezada, S.A., Peggs, K.S., Van Loo, P., Dive, C., Hackshaw, A., Birkbak, N.J., Zaccaria, S., Jamal-Hanjani, M., McGranahan, N. and Swanton, C.
Nature 616
(7957): 534-542.
April 2023
Body composition and lung cancer-associated cachexia in TRACERx.
Al-Sawaf, O., Weiss, J., Skrzypski, M., Lam, J.M., Karasaki, T., Zambrana, F., Kidd, A.C., Frankell, A.M., Watkins, T.B.K., Martínez-Ruiz, C., Puttick, C., Black, J.R.M., Huebner, A., Bakir, M.A., Sokač, M., Collins, S., Veeriah, S., Magno, N., Naceur-Lombardelli, C., Prymas, P., Toncheva, A., Ward, S., Jayanth, N., Salgado, R., Bridge, C.P., Christiani, D.C., Mak, R.H., Bay, C., Rosenthal, M., Sattar, N., Welsh, P., Liu, Y., Perrimon, N., Popuri, K., Beg, M.F., McGranahan, N., Hackshaw, A., Breen, D.M., O'Rahilly, S., Birkbak, N.J., Aerts, H.J.W.L., Jamal-Hanjani, M. and Swanton, C.
Nature Medicine 29
(4): 846-858.
April 2023
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
Karasaki, T., Moore, D.A., Veeriah, S., Naceur-Lombardelli, C., Toncheva, A., Magno, N., Ward, S., Bakir, M.A., Watkins, T.B.K., Grigoriadis, K., Huebner, A., Hill, M.S., Frankell, A.M., Abbosh, C., Puttick, C., Zhai, H., Gimeno-Valiente, F., Saghafinia, S., Kanu, N., Dietzen, M., Pich, O., Lim, E.., Martínez-Ruiz, C., Black, J.R.M., Biswas, D., Campbell, B.B., Lee, C., Colliver, E., Enfield, K.S.S., Hessey, S., Hiley, C.T., Zaccaria, S., Litchfield, K., Birkbak, N.J., Cadieux, E.L., Demeulemeester, J., Van Loo, P., Adusumilli, P.S., Tan, K.S., Cheema, W., Sanchez-Vega, F., Jones, D.R., Rekhtman, N., Travis, W.D., Hackshaw, A., Marafioti, T., Salgado, R., Le Quesne, J., Nicholson, A.G., McGranahan, N., Swanton, C. and Jamal-Hanjani, M.
Nature Medicine 29
(4): 833-845.
April 2023
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L., Petkovic, M., Watkins, T.B.K., Colliver, E.C., Laskina, S., Thapa, N., Minussi, D.C., Navin, N., Swanton, C., Van Loo, P., Haase, K., Tarabichi, M. and Schwarz, R.F.
Genome Biology 23
(1): 241.
14 November 2022
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.
Wu, Y., Biswas, D., Usaite, I., Angelova, M., Boeing, S., Karasaki, T., Veeriah, S., Czyzewska-Khan, J., Morton, C., Joseph, M., Hessey, S., Reading, J., Georgiou, A., Al-Bakir, M., McGranahan, N., Jamal-Hanjani, M., Hackshaw, A., Quezada, S.A., Hayday, A.C. and Swanton, C.
Nature Cancer 3
(6): 696-709.
June 2022
Determinants of expression of SARS-CoV-2 entry related genes in upper and lower airways.
Aliee, H., Massip, F., Qi, C., de Biase, M.S., van Nijnatten, J., Kersten, E.T.G., Kermani, N.Z., Khuder, B., Vonk, J.M., Vermeulen, R.C.H., Neighbors, M., Tew, G.W., Grimbaldeston, M.A., Ten Hacken, N.H.T., Hu, S., Guo, Y., Zhang, X., Sun, K., Hiemstra, P.S., Ponder, B.A., Mäkelä, M.J., Malmström, K., Rintoul, R.C., Reyfman, P.A., Theis, F.J., Brandsma, C.A., Adcock, I.M., Timens, W., Xu, C.J., van den Berge, M., Schwarz, R.F., Koppelman, G.H., Nawijn, M.C. and Faiz, A.
Allergy 77
(2): 690-694.
February 2022
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J., Huska, M., Cwikla, M.C., Kruetzfeldt, L.M., Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y., Burkert, M., Guergen, D., Szymansky, A., Astrahantseff, K., Kuenkele, A., Haase, K., Fischer, M., Deubzer, H.E., Hertwig, F., Hundsdoerfer, P., Henssen, A.G., Schwarz, R.F., Schulte, J.H. and Eggert, A.
Nature Communications 12
(1): 6804.
23 November 2021
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F., Bischoff, P., Peidli, S., Sieber, A., Trinks, A., Lüthen, M., Obermayer, B., Blanc, E., Ruchiy, Y., Sell, T., Mamlouk, S., Arsie, R., Wei, T.T., Klotz-Noack, K., Schwarz, R.F., Sawitzki, B., Kamphues, C., Beule, D., Landthaler, M., Sers, C., Horst, D., Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13
(10): e14123.
7 October 2021
Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham, R., Litchfield, K., Watkins, T.B.K., Lim, E.L., Rosenthal, R., Martínez-Ruiz, C., Hiley, C.T., Bakir, M.A., Salgado, R., Moore, D.A., Jamal-Hanjani, M., Swanton, C. and McGranahan, N.
Nature 597
(7877): 555-560.
23 September 2021
Locus specific epigenetic modalities of random allelic expression imbalance.
Marion-Poll, L., Forêt, B., Zielinski, D., Massip, F., Attia, M., Carter, A.C., Syx, L., Chang, H.Y., Gendrel, A.V. and Heard, E.
Nature Communications 12
(1): 5330.
9 September 2021
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus, C., Luecken, M.D., Eraslan, G., Sikkema, L., Waghray, A., Heimberg, G., Kobayashi, Y., Vaishnav, E.D., Subramanian, A., Smillie, C., Jagadeesh, K.A., Duong, E.T., Fiskin, E., Triglia, E.T., Ansari, M., Cai, P., Lin, B., Buchanan, J., Chen, S., Shu, J., Haber, A.L., Chung, H., Montoro, D.T., Adams, T., Aliee, H., Allon, S.J., Andrusivova, Z., Angelidis, I., Ashenberg, O., Bassler, K., Bécavin, C., Benhar, I., Bergenstråhle, J., Bergenstråhle, L., Bolt, L., Braun, E., Bui, L.T., Callori, S., Chaffin, M., Chichelnitskiy, E., Chiou, J., Conlon, T.M., Cuoco, M.S., Cuomo, A.S.E., Deprez, M., Duclos, G., Fine, D., Fischer, D.S., Ghazanfar, S., Gillich, A., Giotti, B., Gould, J., Guo, M., Gutierrez, A.J., Habermann, A.C., Harvey, T., He, P., Hou, X., Hu, L., Hu, Y., Jaiswal, A., Ji, L., Jiang, P., Kapellos, T.S., Kuo, C.S., Larsson, L., Leney-Greene, M.A., Lim, K., Litviňuková, M., Ludwig, L.S., Lukassen, S., Luo, W., Maatz, H., Madissoon, E., Mamanova, L., Manakongtreecheep, K., Leroy, S., Mayr, C.H., Mbano, I.M., McAdams, A.M., Nabhan, A.N., Nyquist, S.K., Penland, L., Poirion, O.B., Poli, S., Qi, C.C., Queen, R., Reichart, D., Rosas, I., Schupp, J.C., Shea, C.V., Shi, X., Sinha, R., Sit, R.V., Slowikowski, K., Slyper, M., Smith, N.P., Sountoulidis, A., Strunz, M., Sullivan, T.B., Sun, D., Talavera-López, C., Tan, P., Tantivit, J., Travaglini, K.J., Tucker, N.R., Vernon, K.A., Wadsworth, M.H., Waldman, J., Wang, X., Xu, K., Yan, W., Zhao, W. and Ziegler, C.G.K.
Nature Medicine 27
(3): 546-559.
2 March 2021
Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K., Lim, E.L., Petkovic, M., Elizalde, S., Birkbak, N.J., Wilson, G.A., Moore, D.A., Grönroos, E., Rowan, A., Dewhurst, S.M., Demeulemeester, J., Dentro, S.C., Horswell, S., Au, L., Haase, K., Escudero, M., Rosenthal, R., Bakir, M.A., Xu, H., Litchfield, K., Lu, W.T., Mourikis, T.P., Dietzen, M., Spain, L., Cresswell, G.D., Biswas, D., Lamy, P., Nordentoft, I., Harbst, K., Castro-Giner, F., Yates, L.R., Caramia, F., Jaulin, F., Vicier, C., Tomlinson, I.P.M., Brastianos, P.K., Cho, R.J., Bastian, B.C., Dyrskjøt, L., Jönsson, G.B., Savas, P., Loi, S., Campbell, P.J., Andre, F., Luscombe, N.M., Steeghs, N., Tjan-Heijnen, V.C.G., Szallasi, Z., Turajlic, S., Jamal-Hanjani, M., Van Loo, P., Bakhoum, S.F., Schwarz, R.F., McGranahan, N. and Swanton, C.
Nature 587
(7832): 126-132.
5 November 2020
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H., Meyerson, W.U., Dursi, L.J., Wang, L.B., Dong, G., Liang, W.W., Weerasinghe, A., Li, S., Li, Y., Kelso, S., Saksena, G., Ellrott, K., Wendl, M.C., Wheeler, D.A., Getz, G., Simpson, J.T., Gerstein, M.B. and Ding, Li
Nature Communications 11
(1): 4748.
21 September 2020
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
López, S., Lim, E.L., Horswell, S., Haase, K., Huebner, A., Dietzen, M., Mourikis, T.P., Watkins, T.B.K., Rowan, A., Dewhurst, S.M., Birkbak, N.J., Wilson, G.A., Van Loo, P., Jamal-Hanjani, M., Swanton, C. and McGranahan, N.
Nature Genetics 52
(3): 283-293.
March 2020
Pan-cancer analysis of whole genomes.
Nature 578
(7793): 82-93.
6 February 2020
Genomic basis for RNA alterations in cancer.
Calabrese, C., Davidson, N.R., Demircioğlu, D., Fonseca, N.A., He, Y., Kahles, A., Lehmann, K.V., Liu, F., Shiraishi, Y., Soulette, C.M., Urban, L., Greger, L., Li, S., Liu, D., Perry, M.D., Xiang, Q., Zhang, F., Zhang, J., Bailey, P., Erkek, S., Hoadley, K.A., Hou, Y., Huska, M.R., Kilpinen, H., Korbel, J.O., Marin, M.G., Markowski, J., Nandi, T., Pan-Hammarström, Q., Pedamallu, C.S., Siebert, R., Stark, S.G., Su, H., Tan, P., Waszak, S.M., Yung, C., Zhu, S., Awadalla, P., Creighton, C.J., Meyerson, M., Ouellette, B.F.F., Wu, K., Yang, H., Brazma, A., Brooks, A.N., Göke, J., Rätsch, G., Schwarz, R.F., Stegle, O. and Zhang, Z.
Nature 578
(7793): 129-136.
6 February 2020
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y., Chen, F., Fonseca, N.A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., Brazma, A. and Creighton, C.J.
Nature Communications 11
(1): 736.
5 February 2020
Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P., Rodriguez-Fos, E., Helmsauer, K., Burkert, M., MacArthur, I.C., Maag, J., Chamorro, R., Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H., Bei, Y., Röefzaad, C., Bardinet, V., Szymansky, A., Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S., Klironomos, F., Thiessen, N., Blanc, E., Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D., Deubzer, H., Sauer, S., Toedling, J., Fischer, M., Hertwig, F., Schwarz, R.F., Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G.
Nature Genetics 52
(1): 29-34.
January 2020
A clonal expression biomarker associates with lung cancer mortality.
Biswas, D., Birkbak, N.J., Rosenthal, R., Hiley, C.T., Lim, E.L., Papp, K., Boeing, S., Krzystanek, M., Djureinovic, D., La Fleur, L., Greco, M., Döme, B., Fillinger, J., Brunnström, H., Wu, Y., Moore, D.A., Skrzypski, M., Abbosh, C., Litchfield, K., Al Bakir, M., Watkins, T.B.K., Veeriah, S., Wilson, G.A., Jamal-Hanjani, M., Moldvay, J., Botling, J., Chinnaiyan, A.M., Micke, P., Hackshaw, A., Bartek, J., Csabai, I., Szallasi, Z., Herrero, J., McGranahan, N. and Swanton, C.
Nature Medicine 25
(10): 1540-1548.
October 2019
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
Chemi, F., Rothwell, D.G., McGranahan, N., Gulati, S., Abbosh, C., Pearce, S.P., Zhou, C., Wilson, G.A., Jamal-Hanjani, M., Birkbak, N., Pierce, J., Kim, C.S., Ferdous, S., Burt, D.J., Slane-Tan, D., Gomes, F., Moore, D., Shah, R., Al Bakir, M., Hiley, C., Veeriah, S., Summers, Y., Crosbie, P., Ward, S., Mesquita, B., Dynowski, M., Biswas, D., Tugwood, J., Blackhall, F., Miller, C., Hackshaw, A., Brady, G., Swanton, C. and Dive, C.
Nature Medicine 25
(10): 1534-1539.
October 2019
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Joshi, K., de Massy, M.R., Ismail, M., Reading, J.L., Uddin, I., Woolston, A., Hatipoglu, E., Oakes, T., Rosenthal, R., Peacock, T., Ronel, T., Noursadeghi, M., Turati, V., Furness, A.J.S., Georgiou, A., Wong, Y.N.S., Ben Aissa, A., Sunderland, M.W., Jamal-Hanjani, M., Veeriah, S., Birkbak, N.J., Wilson, G.A., Hiley, C.T., Ghorani, E., Guerra-Assunção, J.A., Herrero, J., Enver, T., Hadrup, S.R., Hackshaw, A., Peggs, K.S., McGranahan, N., Swanton, C., Quezada, S.A. and Chain, B.
Nature Medicine 25
(10): 1549-1559.
October 2019
Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints.
Massip, F., Laurent, M., Brossas, C., Fernández-Justel, J.M., Gómez, M., Prioleau, M.N., Duret, L. and Picard, F.
Nucleic Acids Research 47
(10): 5114-5125.
4 June 2019
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.
Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Horswell, S., Chambers, T., O'Brien, T., Lopez, J.I., Watkins, T.B.K., Nicol, D., Stares, M., Challacombe, B., Hazell, S., Chandra, A., Mitchell, T.J., Au, L., Eichler-Jonsson, C., Jabbar, F., Soultati, A., Chowdhury, S., Rudman, S., Lynch, J., Fernando, A., Stamp, G., Nye, E., Stewart, A., Xing, W., Smith, J.C., Escudero, M., Huffman, A., Matthews, N., Elgar, G., Phillimore, B., Costa, M., Begum, S., Ward, S., Salm, M., Boeing, S., Fisher, R., Spain, L., Navas, C., Grönroos, E., Hobor, S., Sharma, S., Aurangzeb, I., Lall, S., Polson, A., Varia, M., Horsfield, C., Fotiadis, N., Pickering, L., Schwarz, R.F., Silva, B., Herrero, J., Luscombe, N.M., Jamal-Hanjani, M., Rosenthal, R., Birkbak, N.J., Wilson, G.A., Pipek, O., Ribli, D., Krzystanek, M., Csabai, I., Szallasi, Z., Gore, M., McGranahan, N., Van Loo, P., Campbell, P., Larkin, J. and Swanton, C.
Cell 173
(3): 595-610.
19 April 2018
Tracking the evolution of non-small-cell lung cancer.
Jamal-Hanjani, M., Wilson, G.A., McGranahan, N., Birkbak, N.J., Watkins, T.B.K., Veeriah, S., Shafi, S., Johnson, D.H., Mitter, R., Rosenthal, R., Salm, M., Horswell, S., Escudero, M., Matthews, N., Rowan, A., Chambers, T., Moore, D.A., Turajlic, S., Xu, H., Lee, S.-M., Forster, M.D., Ahmad, T., Hiley, C.T., Abbosh, C., Falzon, M., Borg, E., Marafioti, T., Lawrence, D., Hayward, M., Kolvekar, S., Panagiotopoulos, N., Janes, S.M., Thakrar, R., Ahmed, A., Blackhall, F., Summers, Y., Shah, R., Joseph, L., Quinn, A.M., Crosbie, P.A., Naidu, B., Middleton, G., Langman, G., Trotter, S., Nicolson, M., Remmen, H., Kerr, K., Chetty, M., Gomersall, L., Fennell, D.A., Nakas, A., Rathinam, S., Anand, G., Khan, S., Russell, P., Ezhil, V., Ismail, B., Irvin-Sellers, M., Prakash, V., Lester, J.F., Kornaszewska, M., Attanoos, R., Adams, H., Davies, H., Dentro, S., Taniere, P., O'Sullivan, B., Lowe, H.L., Hartley, J.A., Iles, N., Bell, H., Ngai, Y., Shaw, J.A., Herrero, J., Szallasi, Z., Schwarz, R.F., Stewart, A., Quezada, S.A., Le Quesne, J., Van Loo, P., Dive, C., Hackshaw, A. and Swanton, C.
New England Journal of Medicine 376
(22): 2109-2121.
1 June 2017
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C., Birkbak, N.J., Wilson, G.A., Jamal-Hanjani, M., Constantin, T., Salari, R., Quesne, J.L., Moore, D.A., Veeriah, S., Rosenthal, R., Marafioti, T., Kirkizlar, E., Watkins, T.B.K., McGranahan, N., Ward, S., Martinson, L., Riley, J., Fraioli, F., Bakir, M.A., Grönroos, E., Zambrana, F., Endozo, R., Bi, W.L., Fennessy, F.M., Sponer, N., Johnson, D., Laycock, J., Shafi, S., Czyzewska-Khan, J., Rowan, A., Chambers, T., Matthews, N., Turajlic, S., Hiley, C., Lee, S.M., Forster, M.D., Ahmad, T., Falzon, M., Borg, E., Lawrence, D., Hayward, M., Kolvekar, S., Panagiotopoulos, N., Janes, S.M., Thakrar, R., Ahmed, A., Blackhall, F., Summers, Y., Hafez, D., Naik, A., Ganguly, A., Kareht, S., Shah, R., Joseph, L., Quinn, A.M., Crosbie, P., Naidu, B., Middleton, G., Langman, G., Trotter, S., Nicolson, M., Remmen, H., Kerr, K., Chetty, M., Gomersall, L., Fennell, D.A., Nakas, A., Rathinam, S., Anand, G., Khan, S., Russell, P., Ezhil, V., Ismail, B., Irvin-Sellers, M., Prakash, V., Lester, J.F., Kornaszewska, M., Attanoos, R., Adams, H., Davies, H., Oukrif, D., Akarca, A.U., Hartley, J.A., Lowe, H.L., Lock, S., Iles, N., Bell, H., Ngai, Y., Elgar, G., Szallasi, Z., Schwarz, R.F., Herrero, J., Stewart, A., Quezada, S.A., Van Loo, P., Dive, C., Lin, C.J., Rabinowitz, M., Aerts, H.J.W.L., Hackshaw, A., Shaw, J.A., Zimmermann, B.G. and Swanton, C.
Nature 545
(7655): 446-451.
25 May 2017
Selbach, Matthias
Natural proteome diversity links aneuploidy tolerance to protein turnover.
Muenzner, J., Trébulle, P., Agostini, F., Zauber, H., Messner, C.B., Steger, M., Kilian, C., Lau, K., Barthel, N., Lehmann, A., Textoris-Taube, K., Caudal, E., Egger, A.S., Amari, F., De Chiara, M., Demichev, V., Gossmann, T.I., Mülleder, M., Liti, G., Schacherer, J., Selbach, M., Berman, J. and Ralser, M.
Nature 630
(8015): 149-157.
6 June 2024
Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15
(1): 3146.
11 April 2024
Cryo-EM captures early ribosome assembly in action.
Qin, B., Lauer, S.M., Balke, A., Vieira-Vieira, C.H., Bürger, J., Mielke, T., Selbach, M., Scheerer, P., Spahn, C.M.T. and Nikolay, R.
Nature Communications 14
(1): 898.
17 February 2023
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146
(23): 1758-1778.
6 December 2022
A critical period of translational control during brain development at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29
(12): 1277-1290.
December 2022
Physiological functions of intracellular protein degradation.
McShane, E. and Selbach, M.
Annual Review of Cell and Developmental Biology 38
: 241-262.
October 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
(10): msac175.
October 2022
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13
(1): 4297.
25 July 2022
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y., Du Jiang, P., Chao, B.N., Cagdas, D., Kubo, S., Balasubramaniyam, A., Zhang, Y., Shadur, B., NaserEddin, A., Folio, L.R., Schwarz, B., Bohrnsen, E., Zheng, L., Lynberg, M., Gottlieb, S., Leney-Greene, M.A., Park, A.Y., Tezcan, I., Akdogan, A., Gocmen, R., Onder, S., Rosenberg, A., Soilleux, E.J., Johnson, E., Jackson, P.K., Demeter, J., Chauvin, S.D., Paul, F., Selbach, M., Bulut, H., Clatworthy, M.R., Tuong, Z.K., Zhang, H., Stewart, B.J., Bosio, C.M., Stepensky, P., Clare, S., Ganesan, S., Pascall, J.C., Daumke, O., Butcher, G.W., McMichael, A.J., Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219
(6): e20201405.
6 June 2022
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82
(11): 2069-2083.
2 June 2022
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C.H., Müller, S., Mastrobuoni, G., Hazapis, O.G., Del Giudice, S., Schwefel, D., Bley, N., Voigt, F., Chao, J.A., Kempa, S., Hüttelmaier, S., Selbach, M. and Landthaler, M.
Nature Communications 13
(1): 2727.
18 May 2022
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H., Flórez, A.F., Kreth, S., Brückner, L.M., Yildiz, U., Gartlgruber, M., Odoni, D.I., Poschet, G., Garbowicz, K., Shao, C., Klein, C., Meier, J., Zeisberger, P., Nadler-Holly, M., Ziehm, M., Paul, F., Burhenne, J., Bell, E., Shaikhkarami, M., Würth, R., Stainczyk, S.A., Wecht, E.M., Kreth, J., Büttner, M., Ishaque, N., Schlesner, M., Nicke, B., Stresemann, C., Llamazares-Prada, M., Reiling, J.H., Fischer, M., Amit, I., Selbach, M., Herrmann, C., Wölfl, S., Henrich, K.O., Höfer, T., Trumpp, A. and Westermann, F.
Nature Cancer 3
(4): 471-485.
28 April 2022
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I.L., Mittermaier, M., Mache, C., Chua, R.L., Knoll, R., Timm, S., Brumhard, S., Krammer, T., Zauber, H., Hiller, A.L., Pascual-Reguant, A., Mothes, R., Bülow, R.D., Schulze, J., Leipold, A.M., Djudjaj, S., Erhard, F., Geffers, R., Pott, F., Kazmierski, J., Radke, J., Pergantis, P., Baßler, K., Conrad, C., Aschenbrenner, A.C., Sawitzki, B., Landthaler, M., Wyler, E., Horst, D., Hippenstiel, S., Hocke, A., Heppner, F.L., Uhrig, A., Garcia, C., Machleidt, F., Herold, S., Elezkurtaj, S., Thibeault, C., Witzenrath, M., Cochain, C., Suttorp, N., Drosten, C., Goffinet, C., Kurth, F., Schultze, J.L., Radbruch, H., Ochs, M., Eils, R., Müller-Redetzky, H., Hauser, A.E., Luecken, M.D., Theis, F.J., Conrad, C., Wolff, T., Boor, P., Selbach, M., Saliba, A.E. and Sander, L.E.
Cell 184
(26): 6243-6261.
22 December 2021
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.
Moreno-Layseca, P., Jäntti, N.Z., Godbole, R., Sommer, C., Jacquemet, G., Al-Akhrass, H., Conway, J.R.W., Kronqvist, P., Kallionpää, R.E., Oliveira-Ferrer, L., Cervero, P., Linder, S., Aepfelbacher, M., Zauber, H., Rae, J., Parton, R.G., Disanza, A., Scita, G., Mayor, S., Selbach, M., Veltel, S. and Ivaska, J.
Nature Cell Biology 23
(10): 1073-1084.
October 2021
Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Nikolay, R., Hilal, T., Schmidt, S., Qin, B., Schwefel, D., Vieira-Vieira, C.H., Mielke, T., Bürger, J., Loerke, J., Amikura, K., Flügel, T., Ueda, T., Selbach, M., Deuerling, E. and Spahn, C.M.T.
Molecular Cell 81
(6): 1200-1215.
18 March 2021
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40
(6): e106094.
15 March 2021
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A., Sieverling, L., Nadler-Holly, M., Ziehm, M., Toprak, U.H., Herrmann, C., Ishaque, N., Okonechnikov, K., Gartlgruber, M., Park, Y.G., Wecht, E.M., Savelyeva, L., Henrich, K.O., Rosswog, C., Fischer, M., Hero, B., Jones, D.T.W., Pfaff, E., Witt, O., Pfister, S.M., Volckmann, Ri., Koster, J., Kiesel, K., Rippe, K., Taschner-Mandl, S., Ambros, P., Brors, B., Selbach, M., Feuerbach, L. and Westermann, F.
Nature Communications 12
(1): 1269.
24 February 2021
Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L., Krupp, F., Harnett, D., Turko, P., Ambrozkiewicz, M.C., Sprink, T., Imami, K., Günnigmann, M., Zinnall, U., Vieira-Vieira, C.H., Schaub, T., Münster-Wandowski, A., Bürger, J., Borisova, E., Yamamoto, H., Rasin, M.R., Ohler, U., Beule, D., Mielke, T., Tarabykin, V., Landthaler, M., Kramer, G., Vida, I., Selbach, M. and Spahn, C.M.T.
Molecular Cell 81
(2): 304-322.
21 January 2021
mRNAs, proteins and the emerging principles of gene expression control.
Buccitelli, C. and Selbach, M.
Nature Reviews Genetics 21
(10): 630-644.
October 2020
Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B., Schmidt, M., Weisbach, H., Gruska, I., Vetter, B., Imami, K., Ostermann, E., Brune, W., Selbach, M., Hagemeier, C. and Wiebusch, L.
Nature Communications 11
(1): 4845.
24 September 2020
The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T., Schmid, M., Dou, Y., Garland, W., Milek, M., Imami, K., Johnsen, D., Polak, P., Andersen, J.S., Selbach, M., Landthaler, M. and Jensen, T.
Nucleic Acids Research 48
(5): 2518-2530.
18 March 2020
Keeping the proportions of protein complex components in check.
Taggart, J.C., Zauber, H., Selbach, M., Li, G.W. and McShane, E.
Cell Systems 10
(2): 125-132.
26 February 2020
The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B., Wang, X., Eichelbaum, K., Sadewasser, A., Husic, I., Paki, K., Budt, M., Hergeselle, M., Vetter, B., Hou, J., Chen, W., Wiebusch, L., Meyer, I.M., Wolff, T. and Selbach, M.
Nature Communications 10
(1): 5518.
4 December 2019
Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K., Imami, K. and Rajewsky, N.
Nature Communications 10
(1): 4205.
16 September 2019
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L., Kärgel, E., Franke, V., McShane, E., Schulz-Beiss, K.W., Patone, G., Schleussner, N., Kolesnichenko, M., Hübner, N., Daumke, O., Selbach, M., Akalin, A., Mathas, S. and Scheidereit, C.
Blood 133
(13): 1489-1494.
28 March 2019
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C., Vieira-Vieira, C.H., Hick, T., Wessels, H.H., Figini, D., Moschall, R., Medenbach, J., Ohler, U., Granneman, S., Selbach, M. and Beckmann, B.M.
Nature Communications 10
(1): 990.
1 March 2019
Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K., Milek, M., Bogdanow, B., Yasuda, T., Kastelic, N., Zauber, H., Ishihama, Y., Landthaler, M. and Selbach, M.
Molecular Cell 72
(1): 84-98.
4 October 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K., Chen, J.X., Selbach, M. and Pelkmans, L.
Nature 559
(7713): 211-216.
July 2018
Picky: a simple online PRM and SRM method designer for targeted proteomics.
Zauber, H., Kirchner, M. and Selbach, M.
Nature Methods 15
(3): 156-157.
28 February 2018
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M., Imami, K., Mukherjee, N., De Bortoli, F., Zinnall, U., Hazapis, O., Trahan, C., Oeffinger, M., Heyd, F., Ohler, U., Selbach, M. and Landthaler, M.
Genome Research 27
(8): 1344-1359.
August 2017
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356
(6335): 307-311.
21 April 2017
Deciphering the ubiquitin code.
Dittmar, G. and Selbach, M.
Molecular Cell 65
(5): 779-780.
2 March 2017
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M., Kirchner, M., Aharoni, R., Ciolli Mattioli, C., van den Bruck, D., Gutkovitch, N., Modepalli, V., Selbach, M., Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45
(2): 938-950.
25 January 2017
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E., Sin, C., Zauber, H., Wells, J.N., Donnelly, N., Wang, X., Hou, J., Chen, W., Storchova, Z., Marsh, J.A., Valleriani, A. and Selbach, M.
Cell 167
(3): 803-815.
20 October 2016
Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7
: 12963.
7 October 2016
The mRNA-bound proteome of the early fly embryo.
Wessels, H.H., Imami, K., Baltz, A.G., Kolinski, M., Beldovskaya, A., Selbach, M., Small, S., Ohler, U. and Landthaler, M.
Genome Research 26
(7): 1000-1009.
July 2016
Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L., Mukherjee, N., Wyler, E., Zauber, H., Hirsekorn, A., Selbach, M., Landthaler, M., Obermayer, B. and Ohler, U.
Nature Methods 13
(2): 165-170.
February 2016
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S., Chu, V.T., Yasuda, T., Franklin, A., Graf, R., Calado, D.P., Li, S., Imami, K., Selbach, M., Di Virgilio, M., Bullinger, L. and Rajewsky, K.
Immunity 43
(6): 1075-1086.
15 December 2015
Extensive identification and analysis of conserved small ORFs in animals.
Mackowiak, S.D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M. and Obermayer, B.
Genome Biology 16
: 179.
14 September 2015
Extensive allele-specific translational regulation in hybrid mice.
Hou, J., Wang, X., McShane, E., Zauber, H., Sun, W., Selbach, M. and Chen, W.
Molecular Systems Biology 11
(8): 825.
7 August 2015
GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C., Moroni, M., Lima, W.C., Wende, H., Kirchner, M., Adelfinger, L., Schrenk-Siemens, K., Tappe-Theodor, A., Wetzel, C., Kuich, P.H., Gassmann, M., Roggenkamp, D., Bettler, B., Lewin, G.R., Selbach, M. and Siemens, J.
Cell 160
(4): 759-770.
12 February 2015
Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.
Stoeckius, M., Grün, D., Kirchner, M., Ayoub, S., Torti, F., Piano, F., Herzog, M., Selbach, M. and Rajewsky, N.
EMBO Journal 33
(16): 1751-1766.
18 August 2014
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124
(8): 3419-3430.
1 August 2014
Gene expression: degrade to derepress.
McShane, E. and Selbach, M.
EMBO Journal 33
(5): 407-408.
3 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
Orchestrated intron retention regulates normal granulocyte differentiation.
Wong, J.J.L., Ritchie, W., Ebner, O.A., Selbach, M., Wong, J.W.H., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T.L., Bailey, C.G., Holst, J. and Rasko, J.E.J.
Cell 154
(3): 583-595.
1 August 2013
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G., Munschauer, M., Schwanhaeusser, B., Vasile, A., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., Wyler, E., Bonneau, R., Selbach, M., Dieterich, C. and Landthaler, M.
Molecular Cell 46
(5): 674-690.
8 June 2012
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Lebedeva, S., Jens, M., Theil, K., Schwanhaeusser, B., Selbach, M., Landthaler, M. and Rajewsky, N.
Molecular Cell 43
(3): 340-352.
5 August 2011
Global quantification of mammalian gene expression control.
Schwanhaeusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W. and Selbach, M.
Nature 473
(7347): 337-342.
19 May 2011
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Luber, C.A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M., Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M. and Mann, M.
Immunity 32
(2): 279-289.
26 February 2010
Quantitative proteomics: a tool to assess cell differentiation.
Vermeulen, M. and Selbach, M.
Current Opinion in Cell Biology 21
(6): 761-766.
December 2009
Host cell interactome of tyrosine-phosphorylated bacterial proteins.
Selbach, M., Paul, F.E., Brandt, S., Guye, P., Daumke, O., Backert, S., Dehio, C. and Mann, M.
Cell Host & Microbe 5
(4): 397-403.
23 April 2009
Widespread changes in protein synthesis induced by microRNAs.
Selbach, M., Schwanhaeusser, B., Thierfelder, N., Fang, Z., Khanin, R. and Rajewsky, N.
Nature 455
(7209): 58-63.
4 September 2008
Sieweke, Michael
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S., Busch, C.J.L., Molawi, K., Geirsdottir, L., Maurizio, J., Vargas Aguilar, S., Belahbib, H., Gimenez, G., Yuda, R.A.A., Burkon, M., Favret, J., Gholamhosseinian Najjar, S., de Laval, B., Kandalla, P.K., Sarrazin, S., Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23
(3): 458-468.
March 2022
Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M., Aaby, P.r, Khader, S.A., Barreiro, L.B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A.R., Dominguez-Andres, J., Duivenvoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K.L., Khan, N., Joosten, L.A.B., Kaufmann, E., Latz, E., Matarese, G., van der Meer, J.W.M., Mhlanga, M., Moorlag, S.J.C.F.M., Mulder, W.J.M., Naik, S., Novakovic, B., O'Neill, L., Ochando, J., Ozato, K., Riksen, N.P., Sauerwein, R., Sherwood, E.R., Schlitzer, A., Schultze, J.L., Sieweke, M.H., Benn, C.S., Stunnenberg, H., Sun, J., van de Veerdonk, F.L., Weis, S., Williams, D.L., Xavier, R. and Netea, M.G.
Nature Immunology 22
(1): 2-6.
January 2021
C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B., Maurizio, J., Kandalla, P.K., Brisou, G., Simonnet, L., Huber, C., Gimenez, G., Matcovitch-Natan, O., Reinhardt, S., David, E., Mildner, A., Leutz, A., Nadel, B., Bordi, C., Amit, I., Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26
(5): 657-674.
May 2020
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L.S., Sodenkamp, J., Hosking, C., Pérez-Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., Wu, X., Bhaw, L., Wende, H., Sieweke, M.H., Elgar, G., Wilson, M., Briscoe, J., Metzis, V., Langhorne, J., Luscombe, N.M. and O'Garra, A.
Nature Immunology 19
(5): 497-507.
May 2018
Trained macrophages support hygiene hypothesis.
de Laval, B. and Sieweke, M.H.
Nature Immunology 18
(12): 1279-1280.
16 November 2017
Developmental origin and maintenance of distinct testicular macrophage populations.
Mossadegh-Keller, N., Gentek, R., Gimenez, G., Bigot, S., Mailfert, S. and Sieweke, M.H.
Journal of Experimental Medicine 214
(10): 2829-2841.
2 October 2017
SIRT1 regulates macrophage self-renewal.
Imperatore, F., Maurizio, J., Vargas Aguilar, S., Busch, C.J., Favret, J., Kowenz-Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., Berruyer, C. and Sieweke, M.H.
EMBO Journal 36
(16): 2353-2372.
15 August 2017
DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L., Nanda, I., Evangelou, K., Nikolova, T., Horn, V., Sagar, Erny, D., Stefanowski, J., Rogell, L., Klein, C., Gharun, K., Follo, M., Seidl, M., Kremer, B., Münke, N., Senges, J., Fliegauf, M., Aschman, T., Pfeifer, D., Sarrazin, S., Sieweke, M.H., Wagner, D., Dierks, C., Haaf, T., Ness, T., Zaiss, M.M., Voll, R.E., Deshmukh, S.D., Prinz, M., Goldmann, T., Hölscher, C., Hauser, A.E., Lopez-Contreras, A.J., Grün, D., Gorgoulis, V., Diefenbach, A., Henneke, P. and Triantafyllopoulou, A.
Cell 167
(5): 1264-1280.
17 November 2016
M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
Kandalla, P.K., Sarrazin, S., Molawi, K., Berruyer, C., Redelberger, D., Favel, A., Bordi, C., de Bentzmann, S. and Sieweke, M.H.
Journal of Experimental Medicine 213
(11): 2269-2279.
10 October 2016
Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O., Winter, D.R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., Keren-Shaul, H., Gury, M., Lara-Astaiso, D., Thaiss, C.A., Cohen, M., Bahar Halpern, K., Baruch, K., Deczkowska, A., Lorenzo-Vivas, E., Itzkovitz, S., Elinav, E., Sieweke, M.H., Schwartz, M. and Amit, I.
Science 353
(6301): aad8670.
19 August 2016
Eosinophils and mast cells: a lineage apart.
Sarrazin, S. and Sieweke, M.H.
Nature Immunology 17
(6): 609-611.
19 May 2016
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L., Weng, Z., Geirsdóttir, L., Molawi, K., Maurizio, J., Fenouil, R., Mossadegh-Keller, N., Gimenez, G., VanHille, L., Beniazza, M., Favret, J., Berruyer, C., Perrin, P., Hacohen, N., Andrau, J.C., Ferrier, P., Dubreuil, P., Sidow, A. and Sieweke, M.H.
Science 351
(6274): aad5510.
12 February 2016
Monocytes compensate Kupffer cell loss during bacterial infection.
Molawi, K. and Sieweke, M.H.
Immunity 42
(1): 10-12.
20 January 2015
Waddington's Valleys and Captain Cook's Islands.
Sieweke, M.H.
Cell Stem Cell 16
(1): 7-8.
8 January 2015
Tissue macrophage identity and self-renewal.
Gentek, R., Molawi, K. and Sieweke, M.H.
Immunological Reviews 262
(1): 56-73.
November 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
Molawi, K., Wolf, Y., Kandalla, P.K., Favret, J., Hagemeyer, N., Frenzel, K., Pinto, A.R., Klapproth, K., Henri, S., Malissen, B., Rodewald, H.R., Rosenthal, N.A., Bajenoff, M., Prinz, M., Jung, S. and Sieweke, M.H.
Journal of Experimental Medicine 211
(11): 2151-2158.
20 October 2014
Beyond stem cells: self-renewal of differentiated macrophages.
Sieweke, M.H. and Allen, J.E.
Science 342
(6161): 1242974.
22 November 2013
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N., Sarrazin, S., Kandalla, P.K., Espinosa, L., Stanley, E.R., Nutt, S.L., Moore, J. and Sieweke, M.H.
Nature 497
(7448): 239-243.
9 May 2013
Siffrin, Volker (ECRC)
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133
(13): e164637.
3 July 2023
Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31
(7): 1569-1584.
July 2020
MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125
(2): 699-714.
2 February 2015
In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S.M., Luenstedt, S., Rinnenthal, J.L., Laube, G., Luche, H., Lehnardt, S., Fehling, H.J., Griesbeck, O. and Zipp, F.
Immunity 33
(3): 424-436.
24 September 2010
Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V., Vogt, J., Radbruch, H., Nitsch, R. and Zipp, F.
Trends in Neurosciences 33
(4): 202-210.
April 2010
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M., Steinman, L., Aktas, O. and Zipp, F.
Nature Medicine 15
(7): 788-793.
July 2009
Sigal, Michael (BIMSB)
p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10
(43): eadp8783.
25 October 2024
Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.
Lin, M. and Sigal, M.
Signal Transduction and Targeted Therapy 8
(1): 419.
6 November 2023
Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C., Berger, H., Liu, L., Mollenkopf, H.J., Strowig, T. and Sigal, M.
Gut Microbes 15
(1): 2233689.
10 July 2023
Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14
(1): 3025.
25 May 2023
R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S., Müllerke, S., Arnold, A., Heuberger, J., Berger, H., Lin, M., Mollenkopf, H.J., Wizenty, J., Horst, D., Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132
(21): e151363.
1 November 2022
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A.S., Mollenkopf, H.J., Berger, H., Tacke, F. and Sigal, M.
EMBO Journal 41
(13): e109996.
4 July 2022
Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D., Oshima, M., Stange, D.E. and Sigal, M.
Gastroenterology 162
(4): 1067-1087.
April 2022
BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13
(1): 1577.
24 March 2022
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J., Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M., Schmuck, R., Mollenkopf, H.J., Brinkmann, V., Tacke, F., Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13
(4): e13191.
9 April 2021
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A., Berger, H., Bouznad, N., Heuberger, J., Boccellato, F., Dobrindt, U., Hermeking, H., Sigal, M. and Meyer, T.F.
Nature Communications 12
(1): 1003.
12 February 2021
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C., Berger, H., Antanaviciute, A., Vidal, R., Sauer, S., Simmons, A., Meyer, T.F. and Sigal, M.
Nature Communications 10
(1): 4368.
25 September 2019
R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M., Del Mar Reinés, M., Müllerke, S., Fischer, C., Kapalczynska, M., Berger, H., Bakker, E.R.M., Mollenkopf, H.J., Rothenberg, M.E., Wiedenmann, B., Sauer, S. and Meyer, T.F.
Nature Cell Biology 21
(7): 812-823.
July 2019
Simon, Katja
Women in Autophagy: an initiative to promote gender parity in science.
McCabe, M., Boya, P., Chen, R.H., Chu, C.T., Colombo, M.I., Delgui, L., Eskelinen, E.L., Hamasaki, M., Hansen, M., He, C., Jäättelä, M., Kimchi, A., Kraft, C., Kundu, M., Melendez, A., Pattingre, S., Proikas-Cezanne, T., Sebti, S., Simon, A.K., Simonsen, A., Tooze, S.A., Vaccaro, M.I., Wang, X., White, E., Zhao, Y. and Cuervo, A.M.
Nature Cell Biology 26
(12): 2009-2012.
December 2024
Nourishing the mind: fasting for brain health.
Hofer, S.J. and Madeo, F.
Cell Metabolism 36
(8): 1635-1637.
6 August 2024
Next questions in autophagy.
Cuervo, A.M., Elazar, Z., Evans, C., Ge, L., Hansen, M., Jäättelä, M., Liang, J.R.A., Loos, B., Mizushima, N., Simon, A.K., Tooze, S., Yoshimori, T. and Nakamura, S.
Nature Cell Biology 26
(5): 661-666.
May 2024
Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.
Borsa, M., Obba, S., Richter, F.C., Zhang, H., Riffelmacher, T., Carrelha, J., Alsaleh, G., Jacobsen, S.E.W. and Simon, A.K.
Autophagy 20
(1): 45-57.
January 2024
Mechanisms of spermidine-induced autophagy and geroprotection.
Hofer, S.J., Simon, A.K., Bergmann, M., Eisenberg, T., Kroemer, G. and Madeo, F.
Nature Aging 2
(12): 1112-1129.
December 2022
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D., Borsa, M., Puleston, D.J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S.S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G. and Simon, A.K.
Nature Communications 13
(1): 5174.
2 September 2022
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y., Du Jiang, P., Chao, B.N., Cagdas, D., Kubo, S., Balasubramaniyam, A., Zhang, Y., Shadur, B., NaserEddin, A., Folio, L.R., Schwarz, B., Bohrnsen, E., Zheng, L., Lynberg, M., Gottlieb, S., Leney-Greene, M.A., Park, A.Y., Tezcan, I., Akdogan, A., Gocmen, R., Onder, S., Rosenberg, A., Soilleux, E.J., Johnson, E., Jackson, P.K., Demeter, J., Chauvin, S.D., Paul, F., Selbach, M., Bulut, H., Clatworthy, M.R., Tuong, Z.K., Zhang, H., Stewart, B.J., Bosio, C.M., Stepensky, P., Clare, S., Ganesan, S., Pascall, J.C., Daumke, O., Butcher, G.W., McMichael, A.J., Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219
(6): e20201405.
6 June 2022
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M.H., Abudu, Y.P., Acevedo-Arozena, A., Adamopoulos, I.E., Adeli, K., Adolph, T.E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B.B., Agnello, M., Agostinis, P., Agrewala, J.N., Agrotis, A., Aguilar, P.V., Ahmad, S.T., Ahmed, Z.M., Ahumada-Castro, U., Aits, S., Aizawa, S., Akkoc, Y., Akoumianaki, T., Akpinar, H.A., Al-Abd, A.M., Al-Akra, L., Al-Gharaibeh, A., Alaoui-Jamali, M.A., Alberti, S., Alcocer-Gómez, E., Alessandri, C., Ali, M., Alim Al-Bari, M.A., Aliwaini, S., Alizadeh, J., Almacellas, E., Almasan, A., Alonso, A., Alonso, G.D., Altan-Bonnet, N., Altieri, D.C., Álvarez, E.M.C., Alves, S., Alves da Costa, C., Alzaharna, M.M., Amadio, M., Amantini, C., Amaral, C., Ambrosio, S., Amer, A.O., Ammanathan, V., An, Z., Andersen, S.U., Andrabi, S.A., Andrade-Silva, M., Andres, A.M., Angelini, S., Ann, D., Anozie, U.C., Ansari, M.Y., Antas, P., Antebi, A., Antón, Z., Anwar, T., Apetoh, L., Apostolova, N., Araki, T., Araki, Y., Arasaki, K., Araújo, W.L., Araya, J., Arden, C., Arévalo, M.A., Arguelles, S., Arias, E., Arikkath, J., Arimoto, H., Ariosa, A.R., Armstrong-James, D., Arnauné-Pelloquin, L., Aroca, A., Arroyo, D.S., Arsov, I., Artero, R., Asaro, D.M.L., Aschner, M., Ashrafizadeh, M., Ashur-Fabian, O., Atanasov, A.G., Au, A.K., Auberger, P., Auner, H.W., Aurelian, L., Autelli, R., Avagliano, L., Ávalos, Y., Aveic, S., Aveleira, C.A., Avin-Wittenberg, T., Aydin, Y., Ayton, S., Ayyadevara, S., Azzopardi, M., Baba, M.u, Backer, J.M., Backues, S.K., Bae, D.H., Bae, O.N., Bae, S.H., Baehrecke, E.H., Baek, A., Baek, S.H., Baek, S.H., Bagetta, G., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, X., Bai, Y., Bairagi, N., Baksi, S., Balbi, T., Baldari, C.T., Balduini, W., Ballabio, A., Ballester, M., Balazadeh, S., Balzan, R., Bandopadhyay, R., Banerjee, S., Banerjee, S., Bánréti, A., Bao, Y., Baptista, M.S., Baracca, A., Barbati, C., Bargiela, A., Barilà, D., Barlow, P.G., Barmada, S.J., Barreiro, E., Barreto, G.E., Bartek, J., Bartel, B., Bartolome, A., Barve, G.R., Basagoudanavar, S.H., Bassham, D.C., Bast, R.C., Basu, A., Batoko, H., Batten, I., Baulieu, E.E., Baumgarner, B.L., Bayry, J., Beale, R., Beau, I., Beaumatin, F., Bechara, L.R.G., Beck, G.R., Beers, M.F., Begun, J., Behrends, C., Behrens, G.M.N., Bei, R., Bejarano, E., Bel, S., Behl, C., Belaid, A., Belgareh-Touzé, N., Bellarosa, C., Belleudi, F., Belló Pérez, M., Bello-Morales, R., Beltran, J.S.O., Beltran, S., Benbrook, D.M., Bendorius, M., Benitez, B.A., Benito-Cuesta, I., Bensalem, J., Berchtold, M.W., Berezowska, S., Bergamaschi, D., Bergami, M., Bergmann, A., Berliocchi, L., Berlioz-Torrent, C., Bernard, A., Berthoux, L., Besirli, C.G., Besteiro, S., Betin, V.M., Beyaert, R., Bezbradica, J.S., Bhaskar, K., Bhatia-Kissova, I., Bhattacharya, R., Bhattacharya, S., Bhattacharyya, S., Bhuiyan, M.S., Bhutia, S.K., Bi, L., Bi, X., Biden, T.J., Bijian, K., Billes, V.A., Binart, N., Bincoletto, C., Birgisdottir, A.B., Bjorkoy, G., Blanco, G., Blas-Garcia, A., Blasiak, J., Blomgran, R., Blomgren, K., Blum, J.S., Boada-Romero, E., Boban, M., Boesze-Battaglia, K., Boeuf, P., Boland, B., Bomont, P., Bonaldo, P., Bonam, S.R., Bonfili, L., Bonifacino, J.S., Boone, B.A., Bootman, M.D., Bordi, M., Borner, C., Bornhauser, B.C., Borthakur, G., Bosch, J., Bose, S., Botana, L.M., Botas, J., Boulanger, C.M., Boulton, M.E., Bourdenx, M., Bourgeois, B., Bourke, N.M., Bousquet, G., Boya, P., Bozhkov, P.V., Bozi, L.H.M., Bozkurt, T.O., Brackney, D.E., Brandts, C.H., Braun, R.J., Braus, G.H., Bravo-Sagua, R., Bravo-San Pedro, J.M., Brest, P., Bringer, M.A., Briones-Herrera, A., Broaddus, V.C., Brodersen, P., Brodsky, J.L., Brody, S.L., Bronson, P.G., Bronstein, J.M., Brown, C.N., Brown, R.E., Brum, P.C., Brumell, J.H., Brunetti-Pierri, N., Bruno, D., Bryson-Richardson, R.J., Bucci, C., Buchrieser, C., Bueno, M., Buitrago-Molina, L.E., Buraschi, S., Buch, S., Buchan, J.R., Buckingham, E.M., Budak, H., Budini, M., Bultynck, G., Burada, F., Burgoyne, J.R., Burón, M.I., Bustos, V., Büttner, S., Butturini, E., Byrd, A., Cabas, I., Cabrera-Benitez, S., Cadwell, K., Cai, J., Cai, L., Cai, Q., Cairó, M., Calbet, J.A., Caldwell, G.A., Caldwell, K.A., Call, J.A., Calvani, R., Calvo, A.C., Calvo-Rubio Barrera, M., Camara, N.O., Camonis, J.H., Camougrand, N., Campanella, M., Campbell, E.M., Campbell-Valois, F.X., Campello, S., Campesi, I., Campos, J.C., Camuzard, O., Cancino, J., Candido de Almeida, D., Canesi, L., Caniggia, I., Canonico, B., Cantí, C., Cao, B., Caraglia, M., Caramés, B., Carchman, E.H., Cardenal-Muñoz, E., Cardenas, C., Cardenas, L., Cardoso, S.M., Carew, J.S., Carle, G.F., Carleton, G., Carloni, S., Carmona-Gutierrez, D., Carneiro, L.A., Carnevali, O., Carosi, J.M., Carra, S., Carrier, A., Carrier, L., Carroll, B., Carter, A.B., Carvalho, A.N., Casanova, M., Casas, C., Casas, J., Cassioli, C., Castillo, E.F., Castillo, K., Castillo-Lluva, S., Castoldi, F., Castori, M., Castro, A.F., Castro-Caldas, M., Castro-Hernandez, J., Castro-Obregon, S., Catz, S.D., Cavadas, C., Cavaliere, F., Cavallini, G., Cavinato, M., Cayuela, M.L., Cebollada Rica, P., Cecarini, V., Cecconi, F., Cechowska-Pasko, M., Cenci, S., Ceperuelo-Mallafré, V., Cerqueira, J.J., Cerutti, J.M., Cervia, D., Cetintas, V.B., Cetrullo, S., Chae, H.J., Chagin, A.S., Chai, C.Y., Chakrabarti, G., Chakrabarti, O., Chakraborty, T., Chakraborty, T., Chami, M., Chamilos, G., Chan, D.W., Chan, E.Y.W., Chan, E.D., Chan, H.Y.E., Chan, H.H., Chan, H., Chan, M.T.V., Chan, Y.S., Chandra, P.K., Chang, C.P., Chang, C., Chang, H.C., Chang, K., Chao, J., Chapman, T., Charlet-Berguerand, N., Chatterjee, S., Chaube, S.K., Chaudhary, A., Chauhan, S., Chaum, E., Checler, F., Cheetham, M.E., Chen, C.S., Chen, G.C., Chen, J.F., Chen, L.L., Chen, L., Chen, L., Chen, M., Chen, M.K., Chen, N., Chen, Q., Chen, R.H., Chen, S., Chen, W., Chen, W., Chen, X.M., Chen, X.W., Chen, X., Chen, Y., Chen, Y.G., Chen, Y., Chen, Y., Chen, Y.J., Chen, Y.Q., Chen, Z.S., Chen, Z., Chen, Z.H., Chen, Z.J., Chen, Z., Cheng, H., Cheng, J., Cheng, S.Y., Cheng, W., Cheng, X., Cheng, X.T., Cheng, Y., Cheng, Z., Chen, Z., Cheong, H., Cheong, J.K., Chernyak, B.V., Cherry, S., Cheung, C.F.R., Cheung, C.H.A., Cheung, K.H., Chevet, E., Chi, R.J., Chiang, A.K.S., Chiaradonna, F., Chiarelli, R., Chiariello, M., Chica, N., Chiocca, S., Chiong, M., Chiou, S.H., Chiramel, A.I., Chiurchiù, V., Cho, D.H., Choe, S.K., Choi, A.M.K., Choi, M.E., Choudhury, K.R., Chow, N.S., Chu, C.T., Chua, J.P., Chua, J.J.E., Chung, H., Chung, K.P., Chung, S., Chung, S.H., Chung, Y.L., Cianfanelli, V., Ciechomska, I.A., Cifuentes, M., Cinque, L., Cirak, S., Cirone, M., Clague, M.J., Clarke, R., Clementi, E., Coccia, E.M., Codogno, P., Cohen, E., Cohen, M.M, Colasanti, T., Colasuonno, F., Colbert, R.A., Colell, A., Čolić, M., Coll, N.S., Collins, M.O., Colombo, M.I., Colón-Ramos, D.A., Combaret, L., Comincini, S., Cominetti, M.R., Consiglio, A., Conte, A., Conti, F., Contu, V.R., Cookson, M.R., Coombs, K.M., Coppens, I., Corasaniti, M.T., Corkery, D.P., Cordes, N., Cortese, K., Costa, M.D.C., Costantino, S., Costelli, P., Coto-Montes, A., Crack, P.J., Crespo, J.L., Criollo, A., Crippa, V., Cristofani, R., Csizmadia, T., Cuadrado, A., Cui, B., Cui, J., Cui, Y., Cui, Y., Culetto, E., Cumino, A.C., Cybulsky, A.V., Czaja, M.J., Czuczwar, S.J., D'Adamo, S., D'Amelio, M., D'Arcangelo, D., D'Lugos, A.C., D'Orazi, G., da Silva, J.A., Dafsari, H.S., Dagda, R.K., Dagdas, Y., Daglia, M., Dai, X., Dai, Y., Dai, Y., Dal Col, J., Dalhaimer, P., Dalla Valle, L., Dallenga, T., Dalmasso, G., Damme, M., Dando, I., Dantuma, N.P., Darling, A.L., Das, H., Dasarathy, S., Dasari, S.K., Dash, S., Daumke, O., Dauphinee, A.N., Davies, J.S., Dávila, V.A., Davis, R.J., Davis, T., Dayalan Naidu, S., De Amicis, F., De Bosscher, K., De Felice, F., De Franceschi, L., De Leonibus, C., de Mattos Barbosa, M.G., De Meyer, G.R.Y., De Milito, A., De Nunzio, C., De Palma, C., De Santi, M., De Virgilio, C., De Zio, D., Debnath, J., DeBosch, B.J., Decuypere, J.P., Deehan, M.A., Deflorian, G., DeGregori, J., Dehay, B., Del Rio, G., Delaney, J.R., Delbridge, L.M.D., Delorme-Axford, E., Delpino, M.V., Demarchi, F., Dembitz, V., Demers, N.D., Deng, H., Deng, Z., Dengjel, J., Dent, P., Denton, D., DePamphilis, M.L., Der, C.J., Deretic, V., Descoteaux, A., Devis, L., Devkota, S., Devuyst, O., Dewson, G., Dharmasivam, M., Dhiman, R., di Bernardo, D., Di Cristina, M., Di Domenico, F., Di Fazio, P., Di Fonzo, A., Di Guardo, G., Di Guglielmo, G.M., Di Leo, L., Di Malta, C., Di Nardo, A., Di Rienzo, M., Di Sano, F., Diallinas, G., Diao, J., Diaz-Araya, G., Díaz-Laviada, I., Dickinson, J.M., Diederich, M., Dieudé, M., Dikic, I., Ding, S., Ding, W.X., Dini, L., Dinić, J., Dinic, M., Dinkova-Kostova, A.T., Dionne, M.S., Distler, J.H.W., Diwan, A., Dixon, I.M.C., Djavaheri-Mergny, M., Dobrinski, I., Dobrovinskaya, O., Dobrowolski, R., Dobson, R.C.J., Đokić, J., Dokmeci Emre, S., Donadelli, M., Dong, B., Dong, X., Dong, Z., Dorn Ii, G.W., Dotsch, V., Dou, H., Dou, J., Dowaidar, M., Dridi, S., Drucker, L., Du, A., Du, C., Du, G., Du, H.N., Du, L.L., du Toit, A., Duan, S.B., Duan, X., Duarte, S.P., Dubrovska, A., Dunlop, E.A., Dupont, N., Durán, R.V., Dwarakanath, B.S., Dyshlovoy, S.A., Ebrahimi-Fakhari, D., Eckhart, L., Edelstein, C.L., Efferth, T., Eftekharpour, E., Eichinger, L., Eid, N., Eisenberg, T., Eissa, N.T., Eissa, S., Ejarque, M., El Andaloussi, A., El-Hage, N., El-Naggar, S., Eleuteri, A.M., El-Shafey, E.S., Elgendy, M., Eliopoulos, A.G., Elizalde, M.M., Elks, P.M., Elsasser, H.P., Elsherbiny, E.S., Emerling, B.M., Emre, N.C.T., Eng, C.H., Engedal, N., Engelbrecht, A.M., Engelsen, A.S.T., Enserink, J.M., Escalante, R., Esclatine, A., Escobar-Henriques, M., Eskelinen, E.L., Espert, L., Eusebio, M.O., Fabrias, G., Fabrizi, C., Facchiano, A., Facchiano, F., Fadeel, B., Fader, C., Faesen, A.C., Fairlie, W.D., Falcó, A., Falkenburger, B.H., Fan, D., Fan, J., Fan, Y., Fang, E.F., Fang, Y., Fang, Y., Fanto, M., Farfel-Becker, T., Faure, M., Fazeli, G., Fedele, A.O., Feldman, A.M., Feng, D., Feng, J., Feng, L., Feng, Y., Feng, Y., Feng, W., Fenz Araujo, T., Ferguson, T.A., Fernández, A.F., Fernandez-Checa, J.C., Fernández-Veledo, S., Fernie, A.R., Ferrante, A.W., Ferraresi, A., Ferrari, M.F., Ferreira, J.C.B., Ferro-Novick, S., Figueras, A., Filadi, R., Filigheddu, N., Filippi-Chiela, E., Filomeni, G., Fimia, G.M., Fineschi, V., Finetti, F., Finkbeiner, S., Fisher, E.A., Fisher, P.B., Flamigni, F., Fliesler, S.J., Flo, T.H., Florance, I., Florey, O., Florio, T., Fodor, E., Follo, C., Fon, E.A., Forlino, A., Fornai, F., Fortini, P., Fracassi, A., Fraldi, A., Franco, B., Franco, R., Franconi, F., Frankel, L.B., Friedman, S.L., Fröhlich, L.F., Frühbeck, G., Fuentes, J.M., Fujiki, Y., Fujita, N., Fujiwara, Y., Fukuda, M., Fulda, S., Furic, L., Furuya, N., Fusco, C., Gack, M.U., Gaffke, L., Galadari, S., Galasso, A., Galindo, M.F., Gallolu Kankanamalage, S., Galluzzi, L., Galy, V., Gammoh, N., Gan, B., Ganley, I.G., Gao, F., Gao, H., Gao, M., Gao, P., Gao, S.J., Gao, W., Gao, X., Garcera, A., Garcia, M.N., Garcia, V.E., García-Del Portillo, F., Garcia-Escudero, V., Garcia-Garcia, A., Garcia-Macia, M., García-Moreno, D., Garcia-Ruiz, C., García-Sanz, P., Garg, A.D., Gargini, R., Garofalo, T., Garry, R.F., Gassen, N.C., Gatica, D., Ge, L., Ge, W., Geiss-Friedlander, R., Gelfi, C., Genschik, P., Gentle, I.E., Gerbino, V., Gerhardt, C., Germain, K., Germain, M., Gewirtz, D.A., Ghasemipour Afshar, E., Ghavami, S., Ghigo, A., Ghosh, M., Giamas, G., Giampietri, C., Giatromanolaki, A., Gibson, G.E., Gibson, S.B., Ginet, V., Giniger, E., Giorgi, C., Girao, H., Girardin, S.E., Giridharan, M., Giuliano, S., Giulivi, C., Giuriato, S., Giustiniani, J., Gluschko, A., Goder, V., Goginashvili, A., Golab, J., Goldstone, D.C., Golebiewska, A., Gomes, L.R., Gomez, R., Gómez-Sánchez, R., Gomez-Puerto, M.C., Gomez-Sintes, R., Gong, Q., Goni, F.M., González-Gallego, J., Gonzalez-Hernandez, T., Gonzalez-Polo, R.A., Gonzalez-Reyes, J.A., González-Rodríguez, P., Goping, I.S., Gorbatyuk, M.S., Gorbunov, N.V., Görgülü, K., Gorojod, R.M., Gorski, S.M., Goruppi, S., Gotor, C., Gottlieb, R.A., Gozes, I., Gozuacik, D., Graef, M., Gräler, M.H., Granatiero, V., Grasso, D., Gray, J.P., Green, D.R., Greenhough, A., Gregory, S.L., Griffin, E.F., Grinstaff, M.W., Gros, F., Grose, C., Gross, A.S., Gruber, F., Grumati, P., Grune, T., Gu, X., Guan, J.L., Guardia, C.M., Guda, K., Guerra, F., Guerri, C., Guha, P., Guillén, C., Gujar, S., Gukovskaya, A., Gukovsky, I., Gunst, J., Günther, A., Guntur, A.R., Guo, C., Guo, C., Guo, H., Guo, L.W., Guo, M., Gupta, P., Gupta, S.K., Gupta, S., Gupta, V.B., Gupta, V., Gustafsson, A.B., Gutterman, D.D., H B, R., Haapasalo, A., Haber, J.E., Hać, A., Hadano, S., Hafrén, A.J., Haidar, M., Hall, B.S., Halldén, G., Hamacher-Brady, A., Hamann, A., Hamasaki, M., Han, W., Hansen, M., Hanson, P.I., Hao, Z., Harada, M., Harhaji-Trajkovic, L., Hariharan, N., Haroon, N., Harris, J., Hasegawa, T., Hasima Nagoor, N., Haspel, J.A., Haucke, V., Hawkins, W.D., Hay, B.A., Haynes, C.M., Hayrabedyan, S.B., Hays, T.S., He, C., He, Q., He, R.R., He, Y.W., He, Y.Y., Heakal, Y., Heberle, A.M., Hejtmancik, J.F., Helgason, G.V., Henkel, V., Herb, M., Hergovich, A., Herman-Antosiewicz, A., Hernández, A., Hernandez, C., Hernandez-Diaz, S., Hernandez-Gea, V., Herpin, A., Herreros, J., Hervás, J.H., Hesselson, D., Hetz, C., Heussler, V.T., Higuchi, Y., Hilfiker, S., Hill, J.A., Hlavacek, W.S., Ho, E.A., Ho, I.H.T., Ho, P.W.L., Ho, S.L., Ho, W.Y., Hobbs, G.A., Hochstrasser, M., Hoet, P.H.M., Hofius, D., Hofman, P., Höhn, A., Holmberg, C.I., Hombrebueno, J.R., Yi-Ren Hong, C.W.H., Hooper, L.V., Hoppe, T., Horos, R., Hoshida, Y., Hsin, I.L., Hsu, H.Y., Hu, B., Hu, D., Hu, L.F., Hu, M.C., Hu, R., Hu, W., Hu, Y.C., Hu, Z.W., Hua, F., Hua, J., Hua, Y., Huan, C., Huang, C., Huang, C., Huang, C., Huang, C., Huang, H., Huang, K., Huang, M.L.H., Huang, R., Huang, S., Huang, T., Huang, X., Huang, Y.J., Huber, T.B., Hubert, V., Hubner, C.A., Hughes, S.M., Hughes, W.E., Humbert, M., Hummer, G., Hurley, J.H., Hussain, S., Hussain, S., Hussey, P.J., Hutabarat, M., Hwang, H.Y., Hwang, S., Ieni, A., Ikeda, F., Imagawa, Y., Imai, Y., Imbriano, C., Imoto, M., Inman, D.M., Inoki, K., Iovanna, J., Iozzo, R.V., Ippolito, G., Irazoqui, J.E., Iribarren, P., Ishaq, M., Ishikawa, M., Ishimwe, N., Isidoro, C., Ismail, N., Issazadeh-Navikas, S., Itakura, E., Ito, D., Ivankovic, D., Ivanova, S., Iyer, A.K.V., Izquierdo, J.M., Izumi, M., Jäättelä, M., Jabir, M.S., Jackson, W.T., Jacobo-Herrera, N., Jacomin, A.C., Jacquin, E., Jadiya, P., Jaeschke, H., Jagannath, C., Jakobi, A.J., Jakobsson, J., Janji, B., Jansen-Dürr, P., Jansson, P.J., Jantsch, J., Januszewski, S., Jassey, A., Jean, S., Jeltsch-David, H., Jendelova, P., Jenny, A., Jensen, T.E., Jessen, N., Jewell, J.L., Ji, J., Jia, L., Jia, R., Jiang, L., Jiang, Q., Jiang, R., Jiang, T., Jiang, X., Jiang, Y., Jimenez-Sanchez, M., Jin, E.J., Jin, F., Jin, H., Jin, L., Jin, L., Jin, M., Jin, S., Jo, E.K., Joffre, C., Johansen, T., Johnson, G.V.W., Johnston, S.A., Jokitalo, E., Jolly, M.K., Joosten, L.A.B., Jordan, J., Joseph, B., Ju, D., Ju, J.S., Ju, J., Juárez, E., Judith, D., Juhász, G., Jun, Y., Jung, C.H., Jung, S.C., Jung, Y.K., Jungbluth, H., Jungverdorben, J., Just, S., Kaarniranta, K., Kaasik, A., Kabuta, T., Kaganovich, D., Kahana, A., Kain, R., Kajimura, S., Kalamvoki, M., Kalia, M., Kalinowski, D.S., Kaludercic, N., Kalvari, I., Kaminska, J., Kaminskyy, V.O., Kanamori, H., Kanasaki, K., Kang, C., Kang, R., Kang, S.S., Kaniyappan, S., Kanki, T., Kanneganti, T.D., Kanthasamy, A.G., Kanthasamy, A., Kantorow, M., Kapuy, O., Karamouzis, M.V., Karim, M.D.R., Karmakar, P., Katare, R.G., Kato, M., Kaufmann, S.H.E., Kauppinen, A., Kaushal, G.P., Kaushik, S., Kawasaki, K., Kazan, K., Ke, P.Y., Keating, D.J., Keber, U., Kehrl, J.H., Keller, K.E., Keller, C.W., Kemper, J.K., Kenific, C.M., Kepp, O., Kermorgant, S., Kern, A., Ketteler, R., Keulers, T.G., Khalfin, B., Khalil, H., Khambu, B., Khan, S.Y., Khandelwal, V.K.M., Khandia, R., Kho, W., Khobrekar, N.V., Khuansuwan, S., Khundadze, M., Killackey, S.A., Kim, D., Kim, D.R., Kim, D.H., Kim, D.E., Kim, E.Y., Kim, E.K., Kim, H.R., Kim, H.S., Kim, H.R., Kim, J.H., Kim, J.K., Kim, J.H., Kim, J., Kim, J.H., Kim, K.I.I., Kim, P.K., Kim, S.J., Kimball, S.R., Kimchi, A., Kimmelman, A.C., Kimura, T., King, M.A., Kinghorn, K.J., Kinsey, C.G., Kirkin, V., Kirshenbaum, L.A., Kiselev, S.L., Kishi, S., Kitamoto, K., Kitaoka, Y., Kitazato, K., Kitsis, R.N., Kittler, J.T., Kjaerulff, O., Klein, P.S., Klopstock, T., Klucken, J., Knævelsrud, H., Knorr, R.L., Ko, B.C.B., Ko, F., Ko, J.L., Kobayashi, H., Kobayashi, S., Koch, I., Koch, J.C., Koenig, U., Kögel, D., Koh, Y.H., Koike, M., Kohlwein, S.D., Kocaturk, N.M., Komatsu, M., König, J., Kono, T., Kopp, B.T., Korcsmaros, T., Korkmaz, G., Korolchuk, V.I., Korsnes, M.S., Koskela, A., Kota, J., Kotake, Y., Kotler, M.L., Kou, Y., Koukourakis, M.I., Koustas, E., Kovacs, A.L., Kovács, T., Koya, D., Kozako, T., Kraft, C., Krainc, D., Krämer, H., Krasnodembskaya, A.D., Kretz-Remy, C., Kroemer, G., Ktistakis, N.T., Kuchitsu, K., Kuenen, S., Kuerschner, L., Kukar, T., Kumar, A., Kumar, A., Kumar, D., Kumar, D., Kumar, S., Kume, S., Kumsta, C., Kundu, C.N., Kundu, M., Kunnumakkara, A.B., Kurgan, L., Kutateladze, T.G., Kutlu, O., Kwak, S.A., Kwon, H.J., Kwon, T.K., Kwon, Y.T., Kyrmizi, I., La Spada, A., Labonté, P., Ladoire, S., Laface, I., Lafont, F., Lagace, D.C., Lahiri, V., Lai, Z., Laird, A.S., Lakkaraju, A., Lamark, T., Lan, S.H., Landajuela, A., Lane, D.J.R., Lane, J.D., Lang, C.H., Lange, C., Langel, Ü., Langer, R., Lapaquette, P., Laporte, J., LaRusso, N.F., Lastres-Becker, I., Lau, W.C.Y., Laurie, G.W., Lavandero, S., Law, B.Y.K., Law, H.K.W., Layfield, R., Le, W., Le Stunff, H., Leary, A.Y., Lebrun, J.J., Leck, L.Y.W., Leduc-Gaudet, J.P., Lee, C., Lee, C.P., Lee, D.H., Lee, E.B., Lee, E.F., Lee, G.M., Lee, H.J., Lee, H.K., Lee, J.M., Lee, J.S., Lee, J.A., Lee, J.Y., Lee, J.H., Lee, M., Lee, M.G., Lee, M.J., Lee, M.S., Lee, S.Y., Lee, S.J., Lee, S.Y., Lee, S.B., Lee, W.H., Lee, Y.R., Lee, Y.H., Lee, Y., Lefebvre, C., Legouis, R., Lei, Y.L., Lei, Y., Leikin, S., Leitinger, G., Lemus, L., Leng, S., Lenoir, O., Lenz, G., Lenz, H.J., Lenzi, P., León, Y., Leopoldino, A.M., Leschczyk, C., Leskelä, S., Letellier, E., Leung, C.T., Leung, P.S., Leventhal, J.S., Levine, B., Lewis, P.A., Ley, K., Li, B., Li, D.Q., Li, J., Li, J., Li, J., Li, K., Li, L., Li, M., Li, M., Li, M., Li, M., Li, M., Li, P.L., Li, M.Q., Li, Q., Li, S., Li, T., Li, W., Li, W., Li, X., Li, Y.P., Li, Y., Li, Z., Li, Z., Li, Z., Lian, J., Liang, C., Liang, Q., Liang, W., Liang, Y., Liang, Y.T., Liao, G., Liao, L., Liao, M., Liao, Y.F., Librizzi, M., Lie, P.P.Y., Lilly, M.A., Lim, H.J., Lima, T.R.R., Limana, F., Lin, C., Lin, C.W., Lin, D.S., Lin, F.C., Lin, J.D., Lin, K.M., Lin, K.H., Lin, L.T., Lin, P.H., Lin, Q., Lin, S., Lin, S.J., Lin, W., Lin, X., Lin, Y.X., Lin, Y.S., Linden, R., Lindner, P., Ling, S.C., Lingor, P., Linnemann, A.K., Liou, Y.C., Lipinski, M.M., Lipovšek, S., Lira, V.A., Lisiak, N., Liton, P.B., Liu, C., Liu, C.H., Liu, C.F., Liu, C.H., Liu, F., Liu, H., Liu, H.S., Liu, H.F., Liu, H., Liu, J., Liu, J., Liu, J., Liu, L., Liu, L., Liu, M., Liu, Q., Liu, W., Liu, W., Liu, X.H., Liu, X., Liu, X., Liu, X., Liu, X., Liu, Y., Liu, Y., Liu, Y., Liu, Y., Liu, Y., Livingston, J.A., Lizard, G., Lizcano, J.M., Ljubojevic-Holzer, S., LLeonart, M.E., Llobet-Navàs, D., Llorente, A., Lo, C.H., Lobato-Márquez, D., Long, Q., Long, Y.C., Loos, B., Loos, J.A., López, M.G., López-Doménech, G., López-Guerrero, J.A., López-Jiménez, A.T., López-Pérez, O., López-Valero, I., Lorenowicz, M.J., Lorente, M., Lorincz, P., Lossi, L., Lotersztajn, S., Lovat, P.E., Lovell, J.F., Lovy, A., Lőw, P., Lu, G., Lu, H., Lu, J.H., Lu, J.J., Lu, M., Lu, S., Luciani, A., Lucocq, J.M., Ludovico, P., Luftig, M.A., Luhr, M., Luis-Ravelo, D., Lum, J.J., Luna-Dulcey, L., Lund, A.H., Lund, V.K., Lünemann, J.D., Lüningschrör, P., Luo, H., Luo, R., Luo, S., Luo, Z., Luparello, C., Lüscher, B., Luu, L., Lyakhovich, A., Lyamzaev, K.G., Lystad, A.H., Lytvynchuk, L., Ma, A.C., Ma, C., Ma, M., Ma, N.F., Ma, Q.H., Ma, X., Ma, Y., Ma, Z., MacDougald, O.A., Macian, F., MacIntosh, G.C., MacKeigan, J.P., Macleod, K.F., Maday, S., Madeo, F., Madesh, M., Madl, T., Madrigal-Matute, J., Maeda, A., Maejima, Y., Magarinos, M., Mahavadi, P., Maiani, E., Maiese, K., Maiti, P., Maiuri, M.C., Majello, B., Major, M.B., Makareeva, E., Malik, F., Mallilankaraman, K., Malorni, W., Maloyan, A., Mammadova, N., Man, G.C.W., Manai, F., Mancias, J.D., Mandelkow, E.M., Mandell, M.A., Manfredi, A.A., Manjili, M.H., Manjithaya, R., Manque, P., Manshian, B.B., Manzano, R., Manzoni, C., Mao, K., Marchese, C., Marchetti, S., Marconi, A.M., Marcucci, F., Mardente, S., Mareninova, O.A., Margeta, M., Mari, M., Marinelli, S., Marinelli, O., Mariño, G., Mariotto, S., Marshall, R.S., Marten, M.R., Martens, S., Martin, A.P.J., Martin, K.R., Martin, S., Martin, S., Martín-Segura, A., Martín-Acebes, M.A., Martin-Burriel, I., Martin-Rincon, M., Martin-Sanz, P., Martina, J.A., Martinet, W., Martinez, A., Martinez, A., Martinez, J., Martinez Velazquez, M., Martinez-Lopez, N., Martinez-Vicente, M., Martins, D.O., Martins, J.O., Martins, W.K., Martins-Marques, T., Marzetti, E., Masaldan, S., Masclaux-Daubresse, C., Mashek, D.G., Massa, V., Massieu, L., Masson, G.R., Masuelli, L., Masyuk, A.I., Masyuk, T.V., Matarrese, P., Matheu, A., Matoba, S., Matsuzaki, S., Mattar, P., Matte, A., Mattoscio, D., Mauriz, J.L., Mauthe, M., Mauvezin, C., Maverakis, E., Maycotte, P., Mayer, J., Mazzoccoli, G., Mazzoni, C., Mazzulli, J.R., McCarty, N., McDonald, C., McGill, M.R., McKenna, S.L., McLaughlin, B.A., McLoughlin, F., McNiven, M.A., McWilliams, T.G., Mechta-Grigoriou, F., Medeiros, T.C., Medina, D.L., Megeney, L.Y., Megyeri, K., Mehrpour, M., Mehta, J.L., Meijer, A.J., Meijer, A.H., Mejlvang, J., Meléndez, A., Melk, A., Memisoglu, G., Mendes, A.F., Meng, D., Meng, F., Meng, T., Menna-Barreto, R., Menon, M.B., Mercer, C., Mercier, A.E., Mergny, J.L., Merighi, A., Merkley, S.D., Merla, G., Meske, V., Mestre, A.C., Metur, S.P., Meyer, C., Meyer, H., Mi, W., Mialet-Perez, J., Miao, J., Micale, L., Miki, Y., Milan, E., Milczarek, M., Miller, D.L., Miller, S.I., Miller, S., Millward, S.W., Milosevic, I., Minina, E.A., Mirzaei, H., Mirzaei, H.R., Mirzaei, M., Mishra, A., Mishra, N., Mishra, P.K., Misirkic Marjanovic, M., Misasi, R., Misra, A., Misso, G., Mitchell, C., Mitou, G., Miura, T., Miyamoto, S., Miyazaki, M., Miyazaki, M., Miyazaki, T., Miyazawa, K., Mizushima, N., Mogensen, T.H., Mograbi, B., Mohammadinejad, R., Mohamud, Y., Mohanty, A., Mohapatra, S., Möhlmann, T., Mohmmed, A., Moles, A., Moley, K.H., Molinari, M., Mollace, V., Møller, A.B., Mollereau, B., Mollinedo, F., Montagna, C., Monteiro, M.J., Montella, A., Montes, L.R., Montico, B., Mony, V.K., Monzio Compagnoni, G., Moore, M.N., Moosavi, M.A., Mora, A.L., Mora, M., Morales-Alamo, D., Moratalla, R., Moreira, P.I., Morelli, E., Moreno, S., Moreno-Blas, D., Moresi, V., Morga, B., Morgan, A.H., Morin, F., Morishita, H., Moritz, O.L., Moriyama, M., Moriyasu, Y., Morleo, M., Morselli, E., Moruno-Manchon, J.F., Moscat, J., Mostowy, S., Motori, E., Moura, A.F., Moustaid-Moussa, N., Mrakovcic, M., Muciño-Hernández, G., Mukherjee, A., Mukhopadhyay, S., Mulcahy Levy, J.M., Mulero, V., Muller, S., Münch, C., Munjal, A., Munoz-Canoves, P., Muñoz-Galdeano, T., Münz, C., Murakawa, T., Muratori, C., Murphy, B.M., Murphy, J.P., Murthy, A., Myöhänen, T.T., Mysorekar, I.U., Mytych, J., Nabavi, S.M., Nabissi, M., Nagy, P., Nah, J., Nahimana, A., Nakagawa, I., Nakamura, K., Nakatogawa, H., Nandi, S.S., Nanjundan, M., Nanni, M., Napolitano, G., Nardacci, R., Narita, M., Nassif, M., Nathan, I., Natsumeda, M., Naude, R.J., Naumann, C., Naveiras, O., Navid, F., Nawrocki, S.T., Nazarko, T.Y., Nazio, F., Negoita, F., Neill, T., Neisch, A.L., Neri, L.M., Netea, M.G., Neubert, P., Neufeld, T.P., Neumann, D., Neutzner, A., Newton, P.T., Ney, P.A., Nezis, I.P., Ng, C.C.W., Ng, T.B., Nguyen, H.T.T., Nguyen, L.T., Ni, H.M., Ní Cheallaigh, C., Ni, Z., Nicolao, M.C., Nicoli, F., Nieto-Diaz, M., Nilsson, P., Ning, S., Niranjan, R., Nishimune, H., Niso-Santano, M., Nixon, R.A., Nobili, A., Nobrega, C., Noda, T., Nogueira-Recalde, U., Nolan, T.M., Nombela, I., Novak, I., Novoa, B., Nozawa, T., Nukina, N., Nussbaum-Krammer, C., Nylandsted, J., O'Donovan, T.R., O'Leary, S.M., O'Rourke, E.J., O'Sullivan, M.P., O'Sullivan, T.E., Oddo, S., Oehme, I., Ogawa, M., Ogier-Denis, E., Ogmundsdottir, M.H., Ogretmen, B., Oh, G.T., Oh, S.H., Oh, Y.J., Ohama, T., Ohashi, Y., Ohmuraya, M., Oikonomou, V., Ojha, R., Okamoto, K., Okazawa, H., Oku, M., Oliván, S., Oliveira, J.M.A., Ollmann, M., Olzmann, J.A., Omari, S., Omary, M.B., Önal, G., Ondrej, M., Ong, S.B., Ong, S.G., Onnis, A., Orellana, J.A., Orellana-Muñoz, S., Ortega-Villaizan, M.D.M., Ortiz-Gonzalez, X.R., Ortona, E., Osiewacz, H.D., Osman, A.H.K., Osta, R., Otegui, M.S., Otsu, K., Ott, C., Ottobrini, L., Ou, J.H.J., Outeiro, T.F., Oynebraten, I., Ozturk, M., Pagès, G., Pahari, S., Pajares, M., Pajvani, U.B., Pal, R., Paladino, S., Pallet, N., Palmieri, M., Palmisano, G., Palumbo, C., Pampaloni, F., Pan, L., Pan, Q., Pan, W:, Pan, X., Panasyuk, G., Pandey, R., Pandey, U.B., Pandya, V., Paneni, F., Pang, S.Y., Panzarini, E., Papademetrio, D.L., Papaleo, E., Papinski, D., Papp, D., Park, E.C., Park, H.T., Park, J.M., Park, J.I., Park, J.T., Park, J., Park, S.C., Park, S.Y., Parola, A.H., Parys, J.B., Pasquier, A., Pasquier, B., Passos, J.F., Pastore, N., Patel, H.H., Patschan, D., Pattingre, S., Pedraza-Alva, G., Pedraza-Chaverri, J., Pedrozo, Z., Pei, G., Pei, J., Peled-Zehavi, H., Pellegrini, J.M., Pelletier, J., Peñalva, M.A., Peng, D., Peng, Y., Penna, F., Pennuto, M., Pentimalli, F., Pereira, C.M.F., Pereira, G.J.S., Pereira, L.C., Pereira de Almeida, L., Perera, N.D., Pérez-Lara, A., Perez-Oliva, A.B., Pérez-Pérez, M.E., Periyasamy, P., Perl, A., Perrotta, C., Perrotta, I., Pestell, R.G., Petersen, M., Petrache, I., Petrovski, G., Pfirrmann, T., Pfister, A.S., Philips, J.A., Pi, H., Picca, A., Pickrell, A.M., Picot, S., Pierantoni, G.M., Pierdominici, M., Pierre, P., Pierrefite-Carle, V., Pierzynowska, K., Pietrocola, F., Pietruczuk, M., Pignata, C., Pimentel-Muiños, F.X., Pinar, M., Pinheiro, R.O., Pinkas-Kramarski, R., Pinton, P., Pircs, K., Piya, S., Pizzo, P., Plantinga, T.S., Platta, H.W., Plaza-Zabala, A., Plomann, M., Plotnikov, E.Y., Plun-Favreau, H., Pluta, R., Pocock, R., Pöggeler, S., Pohl, C., Poirot, M., Poletti, A., Ponpuak, M., Popelka, H., Popova, B., Porta, H., Porte Alcon, S., Portilla-Fernandez, E., Post, M., Potts, M.B., Poulton, J., Powers, T., Prahlad, V., Prajsnar, T.K., Praticò, D., Prencipe, R., Priault, M., Proikas-Cezanne, T., Promponas, V.J., Proud, C.G., Puertollano, R., Puglielli, L., Pulinilkunnil, T., Puri, D., Puri, R., Puyal, J., Qi, X., Qi, Y., Qian, W., Qiang, L., Qiu, Y., Quadrilatero, J., Quarleri, J., Raben, N., Rabinowich, H., Ragona, D., Ragusa, M.J., Rahimi, N., Rahmati, M., Raia, V., Raimundo, N., Rajasekaran, N.S., Ramachandra Rao, S., Rami, A., Ramírez-Pardo, I., Ramsden, D.B., Randow, F., Rangarajan, P.N., Ranieri, D., Rao, H., Rao, L., Rao, R., Rathore, S., Ratnayaka, J.A., Ratovitski, E.A., Ravanan, P., Ravegnini, G., Ray, S.K., Razani, B., Rebecca, V., Reggiori, F., Régnier-Vigouroux, A., Reichert, A.S., Reigada, D., Reiling, J.H., Rein, T., Reipert, S., Rekha, R.S., Ren, H., Ren, J., Ren, W., Renault, T., Renga, G., Reue, K., Rewitz, K., Ribeiro de Andrade Ramos, B., Riazuddin, S.A., Ribeiro-Rodrigues, T.M., Ricci, J.E., Ricci, R., Riccio, V., Richardson, D.R., Rikihisa, Y., Risbud, M.V., Risueño, R.M., Ritis, K., Rizza, S., Rizzuto, R., Roberts, H.C., Roberts, L.D., Robinson, K.J., Roccheri, M.C., Rocchi, S., Rodney, G.G., Rodrigues, T., Rodrigues Silva, V.R., Rodriguez, A., Rodriguez-Barrueco, R., Rodriguez-Henche, N., Rodriguez-Rocha, H., Roelofs, J., Rogers, R.S., Rogov, V.V., Rojo, A.I., Rolka, K., Romanello, V., Romani, L., Romano, A., Romano, P.S., Romeo-Guitart, D., Romero, L.C., Romero, M., Roney, J.C., Rongo, C., Roperto, S., Rosenfeldt, M.T., Rosenstiel, P., Rosenwald, A.G., Roth, K.A., Roth, L., Roth, S., Rouschop, K.M.A., Roussel, B.D., Roux, S., Rovere-Querini, P., Roy, A., Rozieres, A., Ruano, D., Rubinsztein, D.C., Rubtsova, M.P., Ruckdeschel, K., Ruckenstuhl, C., Rudolf, E., Rudolf, R., Ruggieri, A., Ruparelia, A.A., Rusmini, P., Russell, R.R., Russo, G.L., Russo, M., Russo, R., Ryabaya, O.O., Ryan, K.M., Ryu, K.Y., Sabater-Arcis, M., Sachdev, U., Sacher, M., Sachse, C., Sadhu, A., Sadoshima, J., Safren, N., Saftig, P., Sagona, A.P., Sahay, G., Sahebkar, A., Sahin, M., Sahin, O., Sahni, S., Saito, N., Saito, S., Saito, T., Sakai, R., Sakai, Y., Sakamaki, J.I., Saksela, K., Salazar, G., Salazar-Degracia, A., Salekdeh, G.H., Saluja, A.K., Sampaio-Marques, B., Sanchez, M.C., Sanchez-Alcazar, J.A., Sanchez-Vera, V., Sancho-Shimizu, V., Sanderson, J.T., Sandri, M., Santaguida, S., Santambrogio, L., Santana, M.M., Santoni, G., Sanz, A., Sanz, P., Saran, S., Sardiello, M., Sargeant, T.J., Sarin, A., Sarkar, C., Sarkar, S., Sarrias, M.R., Sarkar, S., Sarmah, D.T., Sarparanta, J., Sathyanarayan, A., Sathyanarayanan, R., Scaglione, K.M., Scatozza, F., Schaefer, L., Schafer, Z.T., Schaible, U.E., Schapira, A.H.V., Scharl, M., Schatzl, H.M., Schein, C.H., Scheper, W., Scheuring, D., Schiaffino, M.V., Schiappacassi, M., Schindl, R., Schlattner, U., Schmidt, O., Schmitt, R., Schmidt, S.D., Schmitz, I., Schmukler, E., Schneider, A., Schneider, B.E., Schober, R., Schoijet, A.C., Schott, M.B., Schramm, M., Schröder, B., Schuh, K., Schüller, C., Schulze, R.L., Schürmanns, L., Schwamborn, J.C., Schwarten, M., Scialo, F., Sciarretta, S., Scott, M.J., Scotto, K.W., Scovassi, A.I., Scrima, A., Scrivo, A., Sebastian, D., Sebti, S., Sedej, S., Segatori, L., Segev, N., Seglen, P.O., Seiliez, I., Seki, E., Selleck, S.B., Sellke, F.W., Selsby, J.T., Sendtner, M., Senturk, S., Seranova, E., Sergi, C., Serra-Moreno, R., Sesaki, H., Settembre, C., Setty, S.R.G., Sgarbi, G., Sha, O., Shacka, J.J., Shah, J.A., Shang, D., Shao, C., Shao, F., Sharbati, S., Sharkey, L.M., Sharma, D., Sharma, G., Sharma, K., Sharma, P., Sharma, S., Shen, H.M., Shen, H., Shen, J., Shen, M., Shen, W., Shen, Z., Sheng, R., Sheng, Z., Sheng, Z.H., Shi, J., Shi, X., Shi, Y.H., Shiba-Fukushima, K., Shieh, J.J., Shimada, Y., Shimizu, S., Shimozawa, M., Shintani, T., Shoemaker, C.J., Shojaei, S., Shoji, I., Shravage, B.V., Shridhar, V., Shu, C.W., Shu, H.B., Shui, K., Shukla, A.K., Shutt, T.E., Sica, V., Siddiqui, A., Sierra, A., Sierra-Torre, V., Signorelli, S., Sil, P., Silva, B.J.A., Silva, J.D., Silva-Pavez, E., Silvente-Poirot, S., Simmonds, R.E., Simon, A.K., Simon, H.U., Simons, M., Singh, A., Singh, L.P., Singh, R., Singh, S.V., Singh, S.K., Singh, S.B., Singh, S., Singh, S.P., Sinha, D., Sinha, R.A., Sinha, S., Sirko, A., Sirohi, K., Sivridis, E.L., Skendros, P., Skirycz, A., Slaninová, I., Smaili, S.S., Smertenko, A., Smith, M.D., Soenen, S.J., Sohn, E.J., Sok, S.P.M., Solaini, G., Soldati, T., Soleimanpour, S.A., Soler, R.M., Solovchenko, A., Somarelli, J.A., Sonawane, A., Song, F., Song, H.K., Song, J.X., Song, K., Song, Z., Soria, L.R., Sorice, M., Soukas, A.A., Soukup, S.F., Sousa, D., Sousa, N., Spagnuolo, P.A., Spector, S.A., Srinivas Bharath, M.M., St Clair, D., Stagni, V., Staiano, L., Stalnecker, C.A., Stankov, M.V., Stathopulos, P.B., Stefan, K., Stefan, S.M., Stefanis, L., Steffan, J.S., Steinkasserer, A., Stenmark, H., Sterneckert, J., Stevens, C., Stoka, V., Storch, S., Stork, B., Strappazzon, F., Strohecker, A.M., Stupack, D.G., Su, H., Su, L.Yy, Su, L., Suarez-Fontes, A.M., Subauste, C.S., Subbian, S., Subirada, P.V., Sudhandiran, G., Sue, C.M., Sui, X., Summers, C., Sun, G., Sun, J., Sun, K., Sun, M.X., Sun, Q., Sun, Y., Sun, Z., Sunahara, K.K.S., Sundberg, E., Susztak, K., Sutovsky, P., Suzuki, H., Sweeney, G., Symons, J.D., Sze, S.C.W., Szewczyk, N.J., Tabęcka-Łonczynska, A., Tabolacci, C., Tacke, F., Taegtmeyer, H., Tafani, M., Tagaya, M., Tai, H., Tait, S.W.G., Takahashi, Y., Takats, S., Talwar, P., Tam, C., Tam, S.Y., Tampellini, D., Tamura, A., Tan, C.T., Tan, E.K., Tan, Y.Q., Tanaka, M., Tanaka, M., Tang, D., Tang, J., Tang, T.S., Tanida, I., Tao, Z., Taouis, M., Tatenhorst, L., Tavernarakis, N., Taylor, A., Taylor, G.A., Taylor, J.M., Tchetina, E., Tee, A.R., Tegeder, I., Teis, D., Teixeira, N., Teixeira-Clerc, F., Tekirdag, K.A., Tencomnao, T., Tenreiro, S., Tepikin, A.V., Testillano, P.S., Tettamanti, G., Tharaux, P.L., Thedieck, K., Thekkinghat, A.A., Thellung, S., Thinwa, J.W., Thirumalaikumar, V.P., Thomas, S.M., Thomes, P.G., Thorburn, A., Thukral, L., Thum, T., Thumm, M., Tian, L., Tichy, A., Till, A., Timmerman, V., Titorenko, V.I., Todi, S.V., Todorova, K., Toivonen, J.M., Tomaipitinca, L., Tomar, D., Tomas-Zapico, C., Tomić, S., Tong, B.C.K., Tong, C., Tong, X., Tooze, S.A., Torgersen, M.L., Torii, S., Torres-López, L., Torriglia, A., Towers, C.G., Towns, R., Toyokuni, S., Trajkovic, V., Tramontano, D., Tran, Q.G., Travassos, L.H., Trelford, C.B., Tremel, S., Trougakos, I.P., Tsao, B.P., Tschan, M.P., Tse, H.F., Tse, T.F., Tsugawa, H., Tsvetkov, A.S., Tumbarello, D.A., Tumtas, Y., Tuñón, M.J., Turcotte, S., Turk, B., Turk, V., Turner, B.J., Tuxworth, R.I., Tyler, J.K., Tyutereva, E.V., Uchiyama, Y., Ugun-Klusek, A., Uhlig, H.H., Ułamek-Kozioł, M., Ulasov, I.V., Umekawa, M., Ungermann, C., Unno, R., Urbe, S., Uribe-Carretero, E., Üstün, S., Uversky, V.N., Vaccari, T., Vaccaro, M.I., Vahsen, B.F., Vakifahmetoglu-Norberg, H., Valdor, R., Valente, M.J., Valko, A., Vallee, R.B., Valverde, A.M., Van den Berghe, G., van der Veen, S., Van Kaer, L., van Loosdregt, J., van Wijk, S.J.L., Vandenberghe, W., Vanhorebeek, I., Vannier-Santos, M.A., Vannini, N., Vanrell, M.C., Vantaggiato, C., Varano, G., Varela-Nieto, I., Varga, M., Vasconcelos, M.H., Vats, S., Vavvas, D.G., Vega-Naredo, I., Vega-Rubin-de-Celis, S., Velasco, G., Velázquez, A.P., Vellai, T., Vellenga, E., Velotti, F., Verdier, M., Verginis, P., Vergne, I., Verkade, P., Verma, M., Verstreken, P., Vervliet, T., Vervoorts, J., Vessoni, A.T., Victor, V.M., Vidal, M., Vidoni, C., Vieira, O.V., Vierstra, R.D., Viganó, S., Vihinen, H., Vijayan, V., Vila, M., Vilar, M., Villalba, J.M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M.T., Visnjic, D., Vitale, I., Vocadlo, D.J., Voitsekhovskaja, O.V., Volonté, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M.A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K.A., Wakatsuki, S., Walker, D.W., Walker, M.J., Walker, S.A., Walter, J., Wandosell, F.G., Wang, B., Wang, C.Y., Wang, C., Wang, C., Wang, C., Wang, C.Y., Wang, D., Wang, F., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H., Wang, H., Wang, H.G., Wang, J., Wang, J., Wang, J., Wang, J., Wang, K., Wang, L., Wang, L., Wang, M.H., Wang, M., Wang, N., Wang, P., Wang, P., Wang, P., Wang, P., Wang, Q.J., Wang, Q., Wang, Q.K., Wang, Q.A., Wang, W.T., Wang, W., Wang, X., Wang, X., Wang, Y., Wang, Y., Wang, Y., Wang, Y.Y., Wang, Y., Wang, Y., Wang, Y., Wang, Y., Wang, Z., Wang, Z., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzyńska, A., Weaver, T.E., Wegrzyn, G., Wehman, A.M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergräber, O.H., Weihl, C.C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R.H., Wen, X., Werner, A., Weykopf, B., Wheatley, S.P., Whitton, J.L., Whitworth, A.J., Wiktorska, K., Wildenberg, M.E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R.S.B., Williams, R.L., Williamson, P.R., Wilson, R.A., Winner, B., Winsor, N.J., Witkin, S.S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J.H., Wong, R.W., Wong, V.K.W., Wong, W.L., Wu, A.G., Wu, C., Wu, J., Wu, J., Wu, K.K., Wu, M., Wu, S.Y., Wu, S., Wu, S.Y., Wu, S., Wu, W.K.K., Wu, X., Wu, X., Wu, Y.W., Wu, Y., Xavier, R.J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H.T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C.M., Xie, M., Xie, Y., Xie, Z., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, J.R., Xu, L., Xu, W.W., Xu, X., Xue, Y., Yakhine-Diop, S.M.S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S.J., Yan, Z., Yanagi, Y., Yang, C., Yang, D.S., Yang, H., Yang, H.T., Yang, H., Yang, J.M., Yang, J., Yang, J., Yang, L., Yang, L., Yang, M., Yang, P.M., Yang, Q., Yang, S., Yang, S., Yang, S.F., Yang, W., Yang, W.Y., Yang, X., Yang, X., Yang, Y., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y.G., Yao, Y.M., Yasui, T., Yazdankhah, M., Yen, P.M., Yi, C., Yin, X.M., Yin, Y., Yin, Z., Yin, Z., Ying, M., Ying, Z., Yip, C.K., Yiu, S.P.T., Yoo, Y.H., Yoshida, K., Yoshii, S.R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, J., Yu, L., Yu, M.L., Yu, S.W., Yu, V.C., Yu, W.H., Yu, Z., Yu, Z., Yuan, J., Yuan, L.Q., Yuan, S., Yuan, S.S.F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R.L., Zacks, D.N., Zaffagnini, G., Zambelli, V.O., Zanella, I., Zang, Q.S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K.S., Zarebkohan, A., Zarrouk, A., Zeitlin, S.O., Zeng, J., Zeng, J.D., Žerovnik, E., Zhan, L., Zhang, B., Zhang, D.D., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, H.L., Zhang, J., Zhang, J., Zhang, J.P., Zhang, K.Y.B., Zhang, L.W., Zhang, L., Zhang, L., Zhang, L., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X.W., Zhang, X., Zhang, X., Zhang, X., Zhang, X., Zhang, X.D., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y.D., Zhang, Y., Zhang, Y.Y., Zhang, Y., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X.F., Zhao, Y., Zhao, Y., Zhao, Y., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X.L., Zheng, Y., Zheng, Z.G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, H., Zhou, H., Zhou, J., Zhou, J., Zhou, J., Zhou, J., Zhou, K., Zhou, R., Zhou, X.J., Zhou, Y., Zhou, Y., Zhou, Y., Zhou, Z.Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G.Q., Zhu, H., Zhu, H., Zhu, H., Zhu, W.G., Zhu, Y., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C.M., Ziviani, E., Zoladek, T., Zong, W.X., Zorov, D.B., Zorzano, A., Zou, W., Zou, Z., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X.C., Kenchappa, C.S., Li, Z., Lin, Y., Oshima, S., Rong, Y., Sluimer, J.C., Stallings, C.L. and Tong, C.K.
Autophagy 17
(1): 1-382.
8 February 2021
Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Milojkovic, A. and Simon, A.K.
Autophagy 8
(4): 445-544.
April 2012
Sklenar, Heinz
Nearby stop codons in exons of the neurofibromatosis type 1 gene are disparate splice effectors.
Hoffmeyer, S., Nuernberg, P., Ritter, H., Fahsold, R., Leistner, W., Kaufmann, D. and Krone, W.
American Journal of Human Genetics 62
(2): 269-277.
6 February 1998
Sommer, Thomas
Mechanisms of substrate processing during ER-associated protein degradation.
Christianson, J.C., Jarosch, E. and Sommer, T.
Nature Reviews Molecular Cell Biology 24
(11): 777-796.
November 2023
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40
(6): e106094.
15 March 2021
Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C., Ritterhoff, T., Weber, A., Janowska, M.K., Mustroph, M., Sommer, T. and Klevit, R.E.
EMBO Journal 39
(22): e104863.
16 November 2020
Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11
(1): 103-119.
February 2020
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20
(2): 209-218.
February 2017
Stefan Jentsch (1955-2016) Obituary.
Sommer, T., Hoppe, T. and Rape, M.
Cell Press.
15 December 2016
Stefan Jentsch (1955-2016) Obituary.
Sommer, T., Hoppe, T. and Rape, M.
Cell Press.
15 December 2016
Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
Weber, A., Cohen, I., Popp, O., Dittmar, G., Reiss, Y., Sommer, T., Ravid, T. and Jarosch, E.
Molecular Cell 63
(5): 827-839.
1 September 2016
The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation.
von Delbrück, M., Kniss, A., Rogov, V.V., Pluska, L., Bagola, K., Löhr, F., Güntert, P., Sommer, T. and Dötsch, V.
Molecular Cell 62
(6): 918-928.
16 June 2016
KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv, Y., Shomer, I., Cohen-Kaplan, V., Snijder, B., Superti-Furga, G., Gonen, H., Sommer, T., Ziv, T., Admon, A., Naroditsky, I., Jbara, M., Brik, A., Pikarsky, E., Kwon, Y.T., Doweck, I. and Ciechanover, A.
Cell 161
(2): 333-347.
9 April 2015
Rsp5/Nedd4 clears cells of heat-damaged proteins.
Sommer, T., Weber, A. and Jarosch, E.
Nature Cell Biology 16
(12): 1130-1132.
1 December 2014
Hexosamine pathway metabolites enhance protein quality control and prolong life.
Denzel, M.S., Storm, N.J., Gutschmidt, A., Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T. and Antebi, A.
Cell 156
(6): 1167-1178.
13 March 2014
Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.
Mehnert, M., Sommer, T. and Jarosch, E.
Nature Cell Biology 16
(1): 77-86.
January 2014
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Bagola, K., von Delbrück, M., Dittmar, G., Scheffner, M., Ziv, I., Glickman, M.H., Ciechanover, A. and Sommer, T.
Molecular Cell 50
(4): 528-539.
23 May 2013
The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
Kravtsova-Ivantsiv, Y., Sommer, T. and Ciechanover, A.
Angewandte Chemie International Edition 52
(1): 192-198.
2 January 2013
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.
Shabek, N., Herman-Bachinsky, Y., Buchsbaum, S., Lewinson, O., Haj-Yahya, M., Hejjaoui, M., Lashuel, H.A., Sommer, T., Brik, A. and Ciechanover, A.
Molecular Cell 48
(1): 87-97.
12 October 2012
Finding the will and the way of ERAD substrate retrotranslocation.
Hampton, R.Y. and Sommer, T.
Current Opinion in Cell Biology 24
(4): 460-466.
August 2012
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.
Buchberger, A., Bukau, B. and Sommer, T.
Molecular Cell 40
(2): 238-252.
22 October 2010
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T. and Jarosch, E.
Molecular Cell 36
(5): 782-793.
11 December 2009
The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C., Gauss, R., Horn, S.C., Neuber, O. and Sommer, T.
Nature 458
(7237): 453-460.
26 March 2009
Protein quality control: On IPODs and other JUNQ.
Bagola, K. and Sommer, T.
Current Biology 18
(21): R1019-R1021.
11 November 2008
Lectins in the endoplasmic reticulum: the sweet side of protein quality control.
Sommer, T. and Gauss, R.
Developmental Cell 14
(4): 463-464.
15 April 2008
Coping with stress: cellular relaxation techniques.
Hirsch, C., Gauss, R. and Sommer, T.
Trends in Cell Biology 16
(12): 657-663.
December 2006
Dynamic subcompartmentalization of the mitochondrial inner membrane.
Vogel, F., Bornhoevd, C., Neupert, W. and Reichert, A.S.
Journal of Cell Biology 175
(2): 237-247.
23 October 2006
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
Gauss, R., Jarosch, E., Sommer, T. and Hirsch, C.
Nature Cell Biology 8
(8): 849-854.
August 2006
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.
Gauss, R., Sommer, T. and Jarosch, E.
EMBO Journal 25
(9): 1827-1835.
3 May 2006
Ubx2 links the Cdc48 complex to ER-associated protein degradation.
Neuber, O., Jarosch, E., Volkwein, C., Walter, J. and Sommer, T.
Nature Cell Biology 7
(10): 993-998.
18 September 2005
ERAD: the long road to destruction.
Meusser, B., Hirsch, C., Jarosch, E. and Sommer, T.
Nature Cell Biology 7
(8): 766-772.
August 2005
Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.
Dimmer, K.S., Jakobs, S., Vogel, F., Altmann, K. and Westermann, B.
Journal of Cell Biology 168
(1): 103-115.
3 January 2005
San1p, checking up on nuclear proteins.
Sommer, T. and Hirsch, C.
Cell 120
(6): 734-736.
1 January 2005
Pardon me - No access without ubiquitin.
Sommer, T. and Jarosch, E.
Developmental Cell 8
(1): 4-5.
1 January 2005
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P., Kuemmel, D., Prinz, B., Holz, C., Schultchen, J., Lang, C., Niesen, F.H., Hofmann, K.P., Delbrueck, H., Behlke, J., Mueller, E.C., Jarosch, E., Sommer, T. and Heinemann, U.
EMBO Journal 24
(5): 875-884.
1 January 2005
Varshavsky's contributions.
Baumeister, W., Bachmair, A., Chau, V., Cohen, R., Coffino, P., DeMartino, G., Deshaies, R., Dohmen, J., Emr, S., Finley, D., Hampton, R., Hill, C., Hochstrasser, M., Huber, R., Jackson, P., Jentsch, S., Johnson, E., Kwon, Y.T., Pagano, M., Pickart, C., Rechsteiner, M., Scheffner, M., Sommer, T., Tansey, W., Tyers, M., Vierstra, R., Weissman, A., Wilkinson, K.D. and Wolf, D.
Science 306
(5700): 1290-1292.
1 January 2004
Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation.
Meusser, B. and Sommer, T.
Molecular Cell 14
(2): 247-258.
1 January 2004
The inner membrane protein Mdm33 controls mitochondrial morphology in yeast.
Messerschmitt, M., Jakobs, S., Vogel, F., Fritz, S., Dimmer, K.S., Neupert, W. and Westermann, B.
Journal of Cell Biology 160
(4): 553-564.
18 February 2003
BiP binding keeps ATF6 at bay.
Sommer, T. and Jarosch, E.
Developmental Cell 3
(1): 1-2.
11 July 2002
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H.E.M., Behrens, J., Sommer, T. and Birchmeier, W.
Nature Cell Biology 4
(3): 222-231.
1 March 2002
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
Jarosch, E., Taxis, C., Volkwein, C., Bordallo, J., Finley, D., Wolf, D.H. and Sommer, T.
Nature Cell Biology 4
(2): 134-139.
1 February 2002
Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.
Walter, J., Urban, J., Volkwein, C. and Sommer, T.
EMBO Journal 20
(12): 3124-3131.
1 January 2001
A regulatory link between ER-associated protein degradation and the unfolded-protein response.
Friedlander, R., Jarosch, E., Urban, J., Volkwein, C. and Sommer, T.
Nature Cell Biology 2
(7): 379-384.
1 July 2000
Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle.
Finley, D., Tanaka, K., Mann, C., Feldmann, H., Hochstrasser, M., Vierstra, R., Johnston, S., Hampton, R., Haber, J., Mccusker, J., Silver, P., Frontali, L., Thorsness, P., Varshavsky, A., Byers, B., Madura, K., Reed, S.I., Wolf, D., Jentsch, S., Sommer, T., Baumeister, W., Goldberg, A., Fried, V., Rubin, D.M. and Toh-e, A.
Trends in Biochemical Sciences 23
(7): 244-245.
1 July 1998
Role of Cue1p in ubiquitination and degradition at the ER surface.
Biederer, T., Volkwein, C. and Sommer, T.
Science 278
(5344): 1806-1809.
5 December 1997
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.
Plemper, R.K., Bohmler, S., Bordallo, J., Sommer, T. and Wolf, D.H.
Nature 388
: 891-895.
1 January 1997
Endoplasmic reticulum degradation: reverse protein flow of no return.
Sommer, T. and Wolf, D.H.
FASEB Journal 11
: 1227-1233.
1 January 1997
Importin provides a link between nuclear protein import and U snRNA export.
Goerlich, D., Kraft, R., Kostka, S., Vogel, F., Hartmann, E., Laskey, R.A., Mattaj, I.W. and Izaurralde, E.
Cell 87
(1): 21-32.
4 October 1996
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.
Biederer, T., Volkwein, C. and Sommer, T.
EMBO Journal 15
: 2069-2076.
1 January 1996
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S.cerevisiae.
Finke, K., Plath, K., Panzner, S., Prehn, S., Rapoport, T.A., Hartmann, E. and Sommer, T.
EMBO Journal 15
(7): 1482-1494.
1 January 1996
Distinct functions for the two importin subunits in nuclear protein import.
Goerlich, D., Vogel, F., Mills, A.D., Hartmann, E. and Laskey, R.A.
Nature 377
: 246-248.
1 January 1995
Evolutionary conservation of components of the protein translocation complex.
Hartmann, E., Sommer, T., Prehn, S., Goerlich, D., Jentsch, S. and Rapoport, T.A.
Nature 367
: 654-657.
1 January 1994
Spagnoli, Francesca
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597
(7874): 87-91.
2 September 2021
A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C., Mueller, L., Ruzittu, S., Mah, N., Willnow, D., Darrigrand, J.F., Wilson, H., Khosravinia, D., Mahmoud, A.A., Risolino, M., Selleri, L. and Spagnoli, F.M.
Developmental Cell 55
(2): 150-162.
26 October 2020
Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
Escot, S., Willnow, D., Naumann, H., Di Francescantonio, S. and Spagnoli, F.M.
Nature Communications 9
(1): 5082.
30 November 2018
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I.M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M.A., Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8
: 14127.
13 February 2017
In vivo reprogramming for tissue repair.
Heinrichs, C., Spagnoli, F.M. and Berninger, B.
Nature Cell Biology 17
(3): 204-211.
27 February 2015
Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E., Mah, N., Naumann, H., Pongrac, I.M., Cerdá-Esteban, N., Fontaine, J.F., Wang, Y., Chen, W., Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27
(17): 1932-1946.
1 September 2013
Sperling, Silke (ECRC)
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Lange, M., Kaynak, B., Foerster, U.B., Toenjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S. and Sperling, S.
Genes & Development 22
(17): 2370-2384.
1 September 2008
Sporbert, Anje
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24
(3): 414-422.
March 2023
TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41
(21): e110372.
2 November 2022
A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K., Mensch, J., Grimmig, M.E., Neuner, B., Gorzelniak, K., Türkmen, S., Demuth, I., Hartmann, A., Hartmann, C., Wittig, F., Sporbert, A., Hermann, A., Fuellen, G., Möller, S. and Walter, M.
Science Advances 8
(33): eabk2814.
August 2022
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82
(11): 2069-2083.
2 June 2022
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597
(7874): 87-91.
2 September 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Tay, T.L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, D.M., Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., Staszewski, O., Margineanu, A., Sporbert, A., Steinmetz, L.M., Pospisilik, J.A., Jung, S., Priller, J., Grün, D., Ronneberger, O. and Prinz, M.
Nature Neuroscience 20
(6): 793-803.
June 2017
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry.
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L. and Abdelilah-Seyfried, S.
Developmental Cell 24
(6): 660-667.
25 March 2013
DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.
Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H. and Cardoso, M.C.
Molecular Cell 10
(6): 1355-1365.
December 2002
Dynamics of DNA replication factories in living cells.
Leonhardt, H., Rahn, H.P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D. and Cardoso, M.C.
Journal of Cell Biology 149
(2): 271-279.
17 April 2000
Spranger, Joachim (ECRC)
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187
(4): 387-396.
15 February 2013
Spuler, Simone (ECRC)
Lessons from a negative gene therapy trial for Duchenne muscular dystrophy.
Spuler, S., Borasio, G.D. and Grittner, U.
Nature Medicine
9 October 2024
(In Press)
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13
(1): 4297.
25 July 2022
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
Assessing dysferlinopathy patients over three years with a new motor scale.
Jacobs, M., James, M.K., Lowes, L.P., Alfano, L.N., Eagle, M., Lofra, R.M., Moore, U., Feng, J., Rufibach, L.E., Rose, K., Duong, T., Bello, L., Pedrosa-Hernández, I., Holsten, S., Sakamoto, C., Canal, A., Práxedes, N.S.A., Thiele, S., Siener, C., Vandevelde, B., DeWolf, B., Maron, E., Guglieri, M., Hogrel, J.Y., Blamire, A.M., Carlier, P.G., Spuler, S., Day, J.W., Jones, K.J., Bharucha-Goebel, D.X., Salort-Campana, E., Pestronk, A., Walter, M.C., Paradas, C., Stojkovic, T., Mori-Yoshimura, M., Bravver, E., Díaz-Manera, J., Pegoraro, E., Mendell, J.R., Mayhew, A.G. and Straub, V.
Annals of Neurology 89
(5): 967-978.
May 2021
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M., Franke, V., Brandt, B., Lowenstein, E.D., Schöwel, V., Spuler, S., Akalin, A. and Birchmeier, C.
Nature Communications 11
: 6375.
11 December 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187
(4): 387-396.
15 February 2013
Cardiac involvement in sporadic inclusion-body myositis.
Utz, W., Schmidt, S., Schulz-Menger, J., Luft, F. and Spuler, S.
Circulation 121
(5): 706-708.
9 February 2010
Staroßom, Sarah-Christin (ECRC)
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10
(1): 217.
15 January 2019
Stein, Ulrike (MDC/ECRC)
TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy.
Walther, W., Torke, S. and Stein, U.
Signal Transduction and Targeted Therapy 9
(1): 331.
26 November 2024
Induction of circulating ABCB1 transcripts under platinum-based chemotherapy indicates poor prognosis and a bone micrometastatic phenotype in ovarian cancer patients.
Schwarz, F.M., Kuhlmann, J.D., Kämpfer, J., Klimova, A., Klotz, D.M., Freitag, L., Herrmann, P., Zinnow, V., Smith, J., Scheller, T., Walther, W., Wimberger, P. and Stein, U.
Molecular Cancer 23
(1): 174.
23 August 2024
Neighborhood-level inequalities and influencing factors of COVID-19 incidence in berlin based on Bayesian spatial modelling.
Zhuang, S., Wolf, K., Schmitz, T., Roth, A., Sun, Y., Savaskan, N. and Lakes, T.
Sustainable Cities and Society 104
: 105301.
May 2024
Targeting B cells and microglia in multiple sclerosis with Bruton tyrosine kinase inhibitors: a review.
Dybowski, S., Torke, S. and Weber, M.S.
JAMA Neurology 80
(4): 404-414.
1 April 2023
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13
(1): 1009.
23 February 2022
Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O., Zincke, F., Eckert, A., Kobelt, D., Preissner, S., Liebeskind, J.M., Gunkel, N., Putzker, K., Lewis, J., Preissner, S., Kortüm, B., Walther, W., Mura, K., Bourne, P.E., Stein, U. and Preissner, R.
Clinical and Translational Medicine 12
(2): e726.
20 February 2022
Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann, M., Gambara, G., Brzezicha, B., Popp, O., Pachmayr, E., Wedeken, L., Pflaume, A., Mokritzkij, M., Gül-Klein, S., Brandl, A., Schweiger-Eisbacher, C., Mertins, P., Hoffmann, J., Keilholz, U., Walther, W., Regenbrecht, C., Rau, B. and Stein, U.
Molecular Cancer 20
(1): 129.
21 October 2021
M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
Breitkreuz-Korff, O., Tscheik, C., Del Vecchio, G., Dithmer, S., Walther, W., Orthmann, A., Wolburg, H., Haseloff, R.F., Schröder, L., Blasig, I.E. and Winkler, L.
Journal of Controlled Release 330
: 137-148.
10 August 2021
Quantification of mRNA expression using single-molecule nanopore sensing.
Rozevsky, Y., Gilboa, T., van Kooten, X.F., Kobelt, D., Huttner, D., Stein, U. and Meller, A.
ACS Nano 14
(10): 13964-13974.
27 October 2020
Decoding and targeting the molecular basis of MACC1-driven metastatic spread: lessons from big data mining and clinical-experimental approaches.
Budczies, J., Kluck, K., Walther, W. and Stein, U.
Seminars in Cancer Biology 60
: 365-379.
February 2020
Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies.
Rohr, U.P., Herrmann, P., Ilm, K., Zhang, H., Lohmann, S., Reiser, A., Muranyi, A., Smith, J., Burock, S., Osterland, M., Leith, K., Singh, S., Brunhoeber, P., Bowermaster, R., Tie, J., Christie, M., Wong, H.L., Waring, P., Shanmugam, K., Gibbs, P. and Stein, U.
Annals of Oncology 28
(8): 1869-1875.
1 August 2017
Pancreatic cancer models for translational research.
Behrens, D., Walther, W. and Fichtner, I.
Pharmacology & Therapeutics 173
: 146-158.
May 2017
Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets.
Mudduluru, G., Walther, W., Kobelt, D., Dahlmann, M., Treese, C., Assaraf, Y.G. and Stein, U.
Drug Resistance Updates 26
: 10-27.
May 2016
Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in klatskin tumor patients.
Lederer, A., Herrmann, P., Seehofer, D., Dietel, M., Pratschke, J., Schlag, P. and Stein, U.
Hepatology 62
(3): 841-850.
September 2015
Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.
Nordlinger, B., Sorbye, H., Glimelius, B., Poston, G.J., Schlag, P.M., Rougier, P., Bechstein, W.O., Primrose, J.N., Walpole, E.T., Finch-Jones, M., Jaeck, D., Mirza, D., Parks, R.W., Mauer, M., Tanis, E., Van Cutsem, E., Scheithauer, W. and Gruenberger, T.
Lancet Oncology 14
(12): 1208-1215.
November 2013
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U., Walther, W., Scudiero, D., Selby, M., Kobelt, D., Lemm, M., Fichtner, I., Schlag, P.M., Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103
(13): 1018-1036.
6 July 2011
Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer Randomized Trial 40954.
Schuhmacher, C., Gretschel, S., Lordick, F., Reichardt, P., Hohenberger, W., Eisenberger, C.F., Haag, C., Mauer, M.E., Hasan, B., Welch, J., Ott, K., Hoelscher, A., Schneider, P.M., Bechstein, W., Wilke, H., Lutz, M.P., Nordlinger, B., Van Cutsem, E., Siewert, J.R. and Schlag, P.M.
Journal of Clinical Oncology 28
(35): 5210-5218.
10 December 2010
Heat-responsive gene expression for gene therapy.
Walther, W. and Stein, U.
Advanced Drug Delivery Reviews 61
(7-8): 641-649.
2 July 2009
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F.H., Stein, U., Fichtner, I., Schlag, P.M. and Birchmeier, W.
Gastroenterology 137
(11): 165-175.
July 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15
(1): 59-67.
January 2009
Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.
Nordlinger, B., Sorbye, H., Glimelius, B., Poston, G.J., Schlag, P.M., Rougier, P., Bechstein, W.O., Primrose, J.N., Walpole, E.T., Finch-Jones, M., Jaeck, D., Mirza, D., Parks, R.W., Collette, L., Praet, M., Bethe, U., Van Cutsem, E., Scheithauer, W. and Gruenberger, T.
Lancet 371
(9617): 1007-1016.
22 March 2008
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131
(5): 1486-1500.
November 2006
Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma.
Juettner, S., Wissmann, C., Joens, T., Vieth, M., Hertel, J., Gretschel, S., Schlag, P.M., Kemmner, W. and Hoecker, M.
Journal of Clinical Oncology 24
(2): 228-240.
10 January 2006
Laser microdissection of a colon cancer specimen with subsequent RNA isolation, mRNA amplification and microarray hybridization.
Stoinski-Bungs, E., Seeger, S., Kemmner, W., Scheinert, P. and Krupp, G.
Nature Methods Application Notes
: an10-an11.
1 January 2006
Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B., Sturm, I., Lage, H., Berger, S., Schneider, U., Haupfmann, S., Wust, P., Riess, H., Schlag, P.M., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21
(18): 3391-3401.
15 September 2003
Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial.
Kerr, D.J., McArdle, C.S., Ledermann, J., Taylor, I., Sherlock, D.J., Schlag, P.M., Buckels, J., Mayer, D., Cain, D. and Stephens, R.J.
Lancet 361
(1): 368-373.
1 February 2003
Regional hyperthermia for rectal cancer.
Hildebrandt, B., Wust, P., Rau, B., Schlag, P.M. and Riess, H.
Lancet 356
(9231): 771-772.
26 August 2000
Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1.
Janke, J., Schlueter, K., Jandrig, B., Theile, M., Koelble, K., Arnold, W., Grinstein, E., Schwartz, A., Estevez-Schwarz, L., Schlag, P.M., Jockusch, B.M. and Scherneck, S.
Journal of Experimental Medicine 191
(10): 1675-1685.
15 May 2000
Immunohistochemical detection of lymph-node metastases.
Bembenek, A., Haensch, W., Schneider, U., Markwardt, J. and Schlag, P.M.
Lancet 355
: 144-145.
8 January 2000
Three-dimensional ultrasonography: new prospects for ultrasound imaging of bone.
Huenerbein, M., Raschke, M., Haas, N.P. and Schlag, P.M.
Lancet 355
(9198): 116-117.
8 January 2000
Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP.
Stein, U., Walther, W., Laurencot, C.M., Scheffer, G.L., Scheper, R.J. and Shoemaker, R.H.
Journal of the National Cancer Institute 89
: 807-813.
1 January 1997
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.
Stein, U., Walther, W. and Shoemaker, R.H.
Journal of the National Cancer Institute 88
: 1383-1392.
1 January 1996
Efficient gene transfer into human hepatocytes by baculovirus vectors.
Hofmann, C., Sandig, V., Jennings, G., Rudolph, M., Schlag, P.M. and Strauss, M.
Proceedings of the National Academy of Sciences of the United States of America 92
(22): 10099-10103.
24 October 1995
Sugimoto, Yoichiro
Hif-2α programs oxygen chemosensitivity in chromaffin cells.
Prange-Barczynska, M., Jones, H.A., Sugimoto, Y., Cheng, X., Lima, J.D., Ratnayaka, I., Douglas, G., Buckler, K.J., Ratcliffe, P.J., Keeley, T.P. and Bishop, T.
Journal of Clinical Investigation 134
(18): e174661.
6 August 2024
Thierfelder, Ludwig
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Lincoln, S.E., Parrish, A.M., Dauksaite, V., Vakeel, P., Klaassen, S., Gerull, B., Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R., Perrot, A., Ozcelik, C., Saar, K., Hubner, N. and Gotthardt, M.
Nature Medicine 18
(5): 766-773.
May 2012
Heart development: mitochondria in command of cardiomyocyte differentiation.
Drenckhahn, J.D.
Developmental Cell 21
(3): 392-393.
13 September 2011
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
Drenckhahn, J.D., Schwarz, Q.P., Gray, S., Laskowski, A., Kiriazis, H., Ming, Z., Harvey, R.P., Du, X.J., Thorburn, D.R. and Cox, T.C.
Developmental Cell 15
(4): 521-533.
14 October 2008
Mutations in sarcomere protein genes in left ventricular noncompaction.
Klaassen, S., Probst, S., Oechslin, E., Gerull, B., Krings, G., Schuler, P., Greutmann, M., Huerlimann, D., Yegitbasi, M., Pons, L., Gramlich, M., Drenckhahn, J.D., Heuser, A., Berger, F., Jenni, R. and Thierfelder, L.
Circulation 117
(22): 2893-2901.
3 June 2008
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti, J., Fischer, J., Paskas, S., Heinig, M., Schulz, H., Goesele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., Gross, V., Hummel, O., Maatz, H., Patone, G., Saar, K., Vingron, M., Weldon, S.M., Lindpaintner, K., Hammock, B.D., Rohde, K., Dietz, R., Cook, S.A., Schunck, W.H., Luft, F.C. and Huebner, N.
Nature Genetics 40
(5): 529-537.
May 2008
Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene.
Merner, N.D., Hodgkinson, K.A., Haywood, A.F., Connors, S., French, V.M., Drenckhahn, J.D., Kupprion, C., Ramadanova, K., Thierfelder, L., McKenna, W., Gallagher, B., Morris-Larkin, L., Bassett, A.S., Parfrey, P.S. and Young, T.L.
American Journal of Human Genetics 82
(4): 809-821.
11 April 2008
Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.
Heuser, A., Plovie, E.R., Ellinor, P.T., Grossmann, K.S., Shin, J.T., Wichter, T., Basson, C.T., Lerman, B.B., Sasse-Klaassen, S., Thierfelder, L., MacRae, C.A. and Gerull, B.
American Journal of Human Genetics 79
(6): 1081-1088.
December 2006
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A., Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116
(7): 1825-1828.
July 2006
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
Sasse-Klaassen, S., Probst, S., Gerull, B., Oechslin, E., Nuernberg, P., Heuser, A., Jenni, R., Hennies, H.C. and Thierfelder, L.
Circulation 109
(22): 2720-2723.
8 June 2004
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Gerull, B., Gramlich, M., Atherton, J., McNabb, M., Trombitas, K., Sasse-Klaassen, S., Seidman, J.G., Seidman, C., Granzier, H., Labeit, S., Frenneaux, M. and Thierfelder, L.
Nature Genetics 30
(2): 201-204.
February 2002
Mutations in the cardiac myosin binding protein-c gene on chromosome 11 cause familial hypertrophic cardiomyopathy.
Watkins, H., Conner, D., Thierfelder, L.H., Jarcho, J.A., MacRae, C., McKenna, W.J., Maron, B.J., Seidman, J.G. and Seidman, C.E.
Nature Genetics 11
(4): 434-437.
1 December 1995
Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.
Watkins, H., McKenna, W.J., Thierfelder, L.H., Suk, H.J., Anan, R., Odonoghue, A., Spirito, P., Matsumori, A., Moravec, C.S., Seidman, J.G. and Seidman, C.E.
New England Journal of Medicine 332
(16): 1058-1064.
20 April 1995
Treier, Mathias
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener, J., Baggiolini, A., Pernebrink, M., Dalcher, D., Lerra, L., Cheng, P.F., Varum, S., Häusel, J., Stierli, S., Treier, M., Studer, L., Basler, K., Levesque, M.P., Dummer, R., Santoro, R., Cantù, C. and Sommer, L.
Nature Communications 12
(1): 5056.
20 August 2021
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
Hörl, D., Rojas Rusak, F., Preusser, F., Tillberg, P., Randel, N., Chhetri, R.K., Cardona, A., Keller, P.J., Harz, H., Leonhardt, H., Treier, M. and Preibisch, S.
Nature Methods 16
(9): 870-874.
September 2019
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C.
Genes & Development 19
(6): 733-743.
1 January 2005
Tursun, Baris (BIMSB)
The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans.
Kazmierczak, M., Farré i Díaz, C., Ofenbauer, A., Herzog, S. and Tursun, B.
Nucleic Acids Research 49
(4): e22.
26 February 2021
HOT or not: examining the basis of high-occupancy target regions.
Wreczycka, K., Franke, V., Uyar, B., Wurmus, R., Bulut, S., Tursun, B. and Akalin, A.
Nucleic Acids Research
: gkz460.
20 June 2019
Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M., Karabacak, A., Glahs, A., Kolundzic, E., Hirsekorn, A., Carda, A., Tursun, B., Zinzen, R.P., Lacadie, S.A. and Ohler, U.
Nature Communications 9
(1): 4472.
26 October 2018
G-quadruplex prediction in E. coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch.
Kaplan, O.I., Berber, B., Hekim, N. and Doluca, O.
Nucleic Acids Research 44
(19): 9083-9095.
2 November 2016
Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.
Cochella, L., Tursun, B., Hsieh, Y.W., Galindo, S., Johnston, R.J., Chuang, C.F. and Hobert, O.
Genes & Development 28
(1): 34-43.
1 January 2014
Uckert, Wolfgang
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12
(1): 240.
11 January 2021
Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L., Chen, X., Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129
(1): 324-335.
2 January 2019
Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135
(4): 551.
April 2018
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M., Saydaminova, K., Yumul, R., Krishnan, R., Liu, J., Nagy, E.E., Singh, M., Izsvák, Z., Cattaneo, R., Uckert, W., Palmer, D., Ng, P., Haworth, K.G., Kiem, H.P., Ehrhardt, A., Papayannopoulou, T. and Lieber, A.
Blood 128
(18): 2206-2217.
3 November 2016
Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E., Hilgenberg, E., Stervbo, U., Lampropoulou, V., Shen, P., Bunse, M., Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44
(5): 1114-1126.
17 May 2016
Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M., Kammertoens, T., Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126
(3): 854-858.
1 March 2016
T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice.
Dargel, C., Bassani-Sternberg, M., Hasreiter, J., Zani, F., Bockmann, J.H., Thiele, F., Bohne, F., Wisskirchen, K., Wilde, S., Sprinzl, M.F., Schendel, D.J., Krackhardt, A.M., Uckert, W., Wohlleber, D., Schiemann, M., Stemmer, K., Heikenwälder, M., Busch, D.H., Richter, G., Mann, M. and Protzer, U.
Gastroenterology 149
(4): 1042-1052.
October 2015
Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M., Leitão, C., Leisegang, M., Chen, X., Gavvovidis, I., van der Bruggen, P., Uckert, W., Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33
(4): 402-407.
April 2015
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice.
Krebs, K., Böttinger, N., Huang, L.R., Chmielewski, M., Arzberger, S., Gasteiger, G., Jäger, C., Schmitt, E., Bohne, F., Aichler, M., Uckert, W., Abken, H., Heikenwalder, M., Knolle, P. and Protzer, U.
Gastroenterology 145
(2): 456-465.
August 2013
TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M., Weissbrich, B., Knall, R., Franz, T., Dössinger, G., Bet, J., Paszkiewicz, P.J., Pfeifer, L., Bunse, M., Uckert, W., Holtappels, R., Gillert-Marien, D., Neuenhahn, M., Krackhardt, A., Reddehase, M.J., Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5
(192): 192ra87.
3 July 2013
MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M., Wilde, S., Spranger, S., Milosevic, S., Frankenberger, B., Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120
(11): 3869-3877.
1 November 2010
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M., Linnemann, C., Hooijkaas, A.I., Bies, L., de Witte, M.A., Jorritsma, A., Kaiser, A.D.M., Pouw, N., Debets, R., Kieback, E., Uckert, W., Song, J.Y., Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16
(5): 565-570, 1p following 570.
May 2010
Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.
Wilde, S., Sommermeyer, D., Frankenberger, B., Schiemann, M., Milosevic, S., Spranger, S., Pohla, H., Uckert, W., Busch, D.H. and Schendel, D.J.
Blood 114
(10): 2131-2139.
3 September 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7
(2): 207-215.
February 2006
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells.
Xue, S.A., Gao, L., Hart, D., Gillmore, R., Qasim, W., Thrasher, A., Apperley, J., Engels, B., Uckert, W., Morris, E. and Stauss, H.J.
Blood 106
: 3062-3067.
14 July 2005
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 8699-8704.
20 July 1999
Von Kries, Jens Peter / Nazaré, Marc
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M., Müller, M., Chiha, S., Ren, J., Albat, D., Soicke, A., Dohmen, S., Klein, M., Bruns, J., van Dinther, M., Opitz, R., Lindemann, P., Beerbaum, M., Motzny, K., Roske, Y., Schmieder, P., Volkmer, R., Nazaré, M., Heinemann, U., Oschkinat, H., Ten Dijke, P., Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117
(47): 29684-29690.
24 November 2020
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A., Heynen, G.J., Ciecielski, K.J., Ai, J., Berninger, A., Kabacaoglu, D., Görgülü, K., Dantes, Z., Wörmann, S.M., Diakopoulos, K.N., Karpathaki, A.F., Kowalska, M., Kaya-Aksoy, E., Song, L., Zeeuw van der Laan, E.A., López-Alberca, M.P., Nazaré, M., Reichert, M., Saur, D., Erkan, M.M., Hopt, U.T., Sainz, B., Birchmeier, W., Schmid, R.M., Lesina, M. and Algül, H.
Nature Medicine 24
(7): 954-960.
July 2018
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20
(2): 209-218.
February 2017
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J., Neuenschwander, M., Yu, Y., Däbritz, J.H.M., Neuendorff, N.R., Schleich, K., Bittner, A., Milanovic, M., Beuster, G., Radetzki, S., Specker, E., Reimann, M., Rosenbauer, F., Mathas, S., Lohneis, P., Hummel, M., Dörken, B., von Kries, J.P., Lee, S. and Schmitt, C.A.
Blood 129
(1): 71-81.
5 January 2017
Wallukat, Gerd
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection (authors reply inN Engl J Med. 2005 May 12;352(19):2027-8).
Dragun, D., Mueller, D.N., Braesen, J.H., Fritsche, L., Nieminen-Kelhae, M., Dechend, R., Kintscher, U., Rudolph, B., Hoebeke, J., Eckert, D., Mazak, I., Plehm, R., Schoenemann, C., Unger, T., Budde, K., Neumayer, H.H., Luft, F.C. and Wallukat, G.
New England Journal of Medicine 352
(6): 558-569.
1 January 2005
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase.
Dechend, R., Viedt, C., Mueller, D.N., Ugele, B., Brandes, R.P., Wallukat, G., Park, J.K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J. and Luft, F.C.
Circulation 107
(12): 1632-1639.
1 April 2003
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
Geier, C., Perrot, A., Ozcelik, C., Binner, P., Counsell, D., Hoffmann, K., Pilz, B., Martiniak, Y., Gehmlich, K., van der Ven, P.F.M., Furst, D.O., Vornwald, A., von Hodenberg, E., Nuernberg, P., Scheffold, T., Dietz, R. and Osterziel, K.J.
Circulation 107
(10): 1390-1395.
18 March 2003
Specific removal of β1-adrenergic autoantibodies from patients with idiopathic dilated cardiomyopathy.
Wallukat, G., Mueller, J. and Hetzer, R.
New England Journal of Medicine 347
(22): 1806.
28 November 2002
Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients with dilated cardiomyopathy.
Staudt, A., Boehm, M., Knebel, F., Grosse, Y., Bischoff, C., Hummel, A., Dahm, J.B., Borges, A., Jochmann, N., Wernecke, K.D., Wallukat, G., Baumann, G. and Felix, S.B.
Circulation 106
(19): 2448-2453.
5 November 2002
Calcineurin in human heart hypertrophy.
Ritter, O., Hack, S., Schuh, K., Roethlein, N., Perrot, A., Osterziel, K.J., Schulte, H.D. and Neyses, L.
Circulation 105
(19): 2265-2269.
14 May 2002
Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution.
Staudt, A., Schaeper, F., Stangl, V., Plagemann, A., Bohm, M., Merkel, K., Wallukat, G., Wernecke, K.D., Stangl, K., Baumann, G. and Felix, S.B.
Circulation 103
(22): 2681-2686.
1 January 2001
Both beta2- and beta1-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling ofbeta2-adrenergic receptors to G(s)-protein.
Molenaar, P., Bartel, S., Cochrane, A., Vetter, D., Jalali, H., Pohlner, P., Burrell, K., Karczewski, P., Krause, E.G. and Kaumann, A.
Circulation 102
(15): 1814-1821.
10 October 2000
AT1 receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor.
Dechend, R., Homuth, V., Wallukat, G., Kreuzer, J., Park, J.K., Theuer, J., Juepner, A., Gulba, D.C., Mackman, N., Haller, H. and Luft, F.C.
Circulation 101
: 2382-2387.
23 May 2000
Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy.
Mueller, J., Wallukat, G., Dandel, M., Bieda, H., Brandes, K., Spiegelsberger, S., Nissen, E., Kunze, R. and Hetzer, R.
Circulation 101
(4): 385-391.
1 February 2000
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Wallukat, G., Homuth, V., Fischer, T., Lindschau, C., Horstkamp, B., Jupner, A., Baur, E., Nissen, E., Vetter, K., Neichel, D., Dudenhausen, J.W., Haller, H. and Luft, F.C.
Journal of Clinical Investigation 103
(7): 945-952.
1 April 1999
Molecular mimicry between the immunodominant ribosomal protein PO of Trypanosoma cruzi and a functional epitope on the human beta1-adrenergic receptor.
Ferrari, I., Levin, M.J., Wallukat, G., Elies, R., Lebesgue, D., Chiale, P., Elizari, M., Rosenbaum, M. and Hoebeke, J.
Journal of Experimental Medicine 182
(1): 59-65.
1 July 1995
Functional autoimmune epitope on alpha1- adrenergic receptors in patients with malignant hypertension.
Fu, M.L.X., Herlitz, H., Wallukat, G., Hilme, E., Hedner, T., Hoebeke, J. and Hjalmarson, A.
Lancet 344
(8938): 1660-1663.
17 December 1994
Walther, Wolfgang
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U., Walther, W., Scudiero, D., Selby, M., Kobelt, D., Lemm, M., Fichtner, I., Schlag, P.M., Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103
(13): 1018-1036.
6 July 2011
Heat-responsive gene expression for gene therapy.
Walther, W. and Stein, U.
Advanced Drug Delivery Reviews 61
(7-8): 641-649.
2 July 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15
(1): 59-67.
January 2009
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131
(5): 1486-1500.
November 2006
Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP.
Stein, U., Walther, W., Laurencot, C.M., Scheffer, G.L., Scheper, R.J. and Shoemaker, R.H.
Journal of the National Cancer Institute 89
: 807-813.
1 January 1997
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.
Stein, U., Walther, W. and Shoemaker, R.H.
Journal of the National Cancer Institute 88
: 1383-1392.
1 January 1996
Wang, Jichang
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
(2): 327-346.
February 2016
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S., Fuchs, N.V., Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J.L., Faulkner, G.J. and Schumann, G.G.
Nature Communications 7
: 10286.
8 January 2016
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
Wanker, Erich
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner, D., Sieverding, K., Srinidhi, J., Zellner, S., Secker, C., Yilmaz, R., Dyckow, J., Amr, S., Ponomarenko, A., Tunaboylu, E., Douahem, Y., Schlag, J.S., Rodríguez Martínez, L., Kislinger, G., Niemann, C., Nalbach, K., Ruf, W.P., Uhl, J., Hollenbeck, J., Schirmer, L., Catanese, A., Lobsiger, C.S., Danzer, K.M., Yilmazer-Hanke, D., Münch, C., Koch, P., Freischmidt, A., Fetting, M., Behrends, C., Parlato, R. and Weishaupt, J.H.
Journal of Experimental Medicine 221
(5): e20221190.
22 March 2024
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Poh, J., Ponsford, A.H., Boyd, J., Woodsmith, J., Stelzl, U., Wanker, E., Harper, N., MacEwan, D. and Sanderson, C.M.
Redox Biology 37
: 101686.
October 2020
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M., Alpaugh, M., Sciacca, G., Saint-Pierre, M., Masnata, M., Denis, H.L., Lévesque, S.A., Herrmann, F., Bazenet, C., Garneau, A.P., Isenring, P., Truant, R., Oueslati, A., Gould, P.V., Ast, A., Wanker, E.E., Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 26
(9): 5441–5463.
September 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T., Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M., Zink, A., Chondrogianni, N., Psomopoulos, F., Prigione, A., Ivics, Z., Pospisilova, S., Skladal, P., Izsvák, Z., Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
Maximizing binary interactome mapping with a minimal number of assays.
Choi, S.G., Olivet, J., Cassonnet, P., Vidalain, P.O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E.P., Janin, Y.L., van der Werf, S., Trepte, P., Wanker, E.E., De Las Rivas, J., Tavernier, J., Twizere, J.C., Hao, T., Hill, D.E., Vidal, M., Calderwood, M.A. and Jacob, Y.
Nature Communications 10
(1): 3907.
29 August 2019
mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A., Buntru, A., Schindler, F., Hasenkopf, R., Schulz, A., Brusendorf, L., Klockmeier, K., Grelle, G., McMahon, B., Niederlechner, H., Jansen, I., Diez, L., Edel, J., Boeddrich, A., Franklin, S.A., Baldo, B., Schnoegl, S., Kunz, S., Purfürst, B., Gaertner, A., Kampinga, H.H., Morton, A.J., Petersén, Å., Kirstein, J., Bates, G.P. and Wanker, E.E.
Molecular Cell 71
(5): 675-688.
6 September 2018
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A., Buntru, A., Arnsburg, K., Ast, A., Iburg, M., Juenemann, K., Pigazzini, M.L., Mlody, B., Puchkov, D., Priller, J., Wanker, E.E., Prigione, A. and Kirstein, J.
EMBO Journal 37
(2): 282-299.
17 January 2018
Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49
: 71-76.
December 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
Vöpel, T., Bravo-Rodriguez, K., Mittal, S., Vachharajani, S., Gnutt, D., Sharma, A., Steinhof, A., Fatoba, O., Ellrichmann, G., Nshanian, M., Heid, C., Loo, J.A., Klärner, F.-G., Schrader, T., Bitan, G., Wanker, E.E., Ebbinghaus, S. and Sanchez-Garcia, E.
Journal of the American Chemical Society 139
(16): 5640-5643.
26 April 2017
Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M.A., Aprile, F.A., Seinstra, R.I., Stroo, E., Prins, R.W., Martineau, C.N., Wang, H.H., Hogewerf, Wytse, Steinhof, A., Wanker, E.E., Vendruscolo, M., Calkhoven, C.F., Reinke, V., Guryev, V. and Nollen, E.A.A.
Molecular Cell 65
(6): 1096-1108.
16 March 2017
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
A glycolytic solution for pluripotent stem cells.
Mlody, B. and Prigione, A.
Cell Stem Cell 19
(4): 419-420.
6 October 2016
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
(2): 327-346.
February 2016
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A., Prigione, A., Cramer, T., Wamelink, M.M.C., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N.M., Krueger, A., Tauqeer Alam, M., Keller, M.A., Breitenbach, M., Brindle, K.M., Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90
(3): 927-963.
August 2015
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M., Bounab, Y., Strempel, N., Klockmeier, K., Yigit, S., Friedrich, R.P., Chaurasia, G., Li, S., Hesse, F., Riechers, S.P., Russ, J., Nicoletti, C., Boeddrich, A., Wiglenda, T., Haenig, C., Schnoegl, S., Fournier, D., Graham, R.K., Hayden, M.R., Sigrist, S., Bates, G.P., Priller, J., Andrade-Navarro, M.A., Futschik, M.E. and Wanker, E.E.
Genome Research 25
(5): 701-713.
May 2015
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S.G.M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S.I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E.E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V.M. and Okazawa, H.
Molecular Psychiatry 20
(4): 459-471.
April 2015
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M., Landles, C., Weiss, A., Bradaia, A., Seredenina, T., Inuabasi, L., Osborne, G.F., Wadel, K., Touller, C., Butler, R., Robertson, J., Franklin, S.A., Smith, D.L., Park, L., Marks, P.A., Wanker, E.E., Olson, E.N., Luthi-Carter, R., van der Putten, H., Beaumont, V. and Bates, G.P.
PLoS Biology 11
(11): e1001717.
November 2013
A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M., Grossmann, A., Woodsmith, J., Özkan, Z., Birth, P., Meierhofer, D., Benlasfer, N., Valovka, T., Timmermann, B., Wanker, E.E., Sauer, S. and Stelzl, U.
Nature Methods 10
(4): 339-342.
April 2013
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S., Griesche, N., Jastrzebska, E., Chen, C., Rutschow, D., Achmüller, C., Dorn, S., Boesch, S.M., Lalowski, M., Wanker, E., Schneider, R. and Schweiger, S.
Nature Communications 4
: 1511.
26 February 2013
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K., Nakamura, Y., Oka, T., Ito, H., Tamura, T., Tagawa, K., Sasabe, T., Katsuta, A., Motoki, K., Shiwaku, H., Sone, M., Yoshida, C., Katsuno, M., Eishi, Y., Murata, M., Taylor, J.P., Wanker, E.E., Kono, K., Tashiro, S., Sobue, G., La Spada, A.R. and Okazawa, H.
Nature Communications 4
: 1816.
2013
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Lopez Del Amo, J.M., Gruening, B.A., Wang, Q., Schmidt, M.R., Lurz, R., Anwyl, R., Schnoegl, S., Faendrich, M., Frank, R.F., Reif, B., Guenther, S., Walsh, D.M. and Wanker, E.E.
Nature Chemical Biology 8
(1): 93-101.
January 2012
An empirical framework for binary interactome mapping.
Venkatesan, K., Rual, J.F., Vazquez, A., Stelzl, U., Lemmens, I., Hirozane-Kishikawa, T., Hao, T., Zenkner, M., Xin, X., Goh, K.I., Yildirim, M.A., Simonis, N., Heinzmann, K., Gebreab, F., Sahalie, J.M., Cevik, S., Simon, C., de Smet, A.S., Dann, E., Smolyar, A., Vinayagam, A., Yu, H., Szeto, D., Borick, H., Dricot, A., Klitgord, N., Murray, R.R., Lin, C., Lalowski, M., Timm, J., Rau, K., Boone, C., Braun, P., Cusick, M.E., Roth, F.P., Hill, D.E., Tavernier, J., Wanker, E.E., Barabasi, A.L. and Vidal, M.
Nature Methods 6
(1): 83-90.
January 2009
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Pastore, A. and Wanker, E.E.
Nature Structural & Molecular Biology 15
(6): 558-566.
June 2008
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Qi, M.L., Tagawa, K., Enokido, Y., Yoshimura, N., Wada, Y.I., Watase, K., Ishiura, S.I., Kanazawa, I., Botas, J., Saitoe, M., Wanker, E.E. and Okazawa, H.
Nature Cell Biology 9
(4): 402-414.
April 2007
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich, A., Gaumer, S., Haacke, A., Tzvetkov, N., Albrecht, M., Evert, B.O., Mueller, E.C., Lurz, R., Breuer, P., Schugardt, N., Plassmann, S., Xu, K., Warrick, J.M., Suopanki, J., Wuellner, U., Frank, R., Hartl, U.F., Bonini, N.M. and Wanker, E.E.
EMBO Journal 25
(7): 1547-1558.
5 April 2006
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Hoshino, M., Qi, M.L., Yoshimura, N., Miyashita, T., Tagawa, K., Wada, Y.I., Enokido, Y., Marubuchi, S., Arai, P., Arai, N., Oyanagi, K., Blandino, G., Sudol, M., Rich, T., Kanazawa, I., Wanker, E.E., Saitoe, M. and Okazawa, H.
Journal of Cell Biology 172
(4): 589-604.
13 February 2006
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoez, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H. and Wanker, E.E.
Cell 122
(6): 957-968.
23 September 2005
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang, X., Smith, D.L., Meriin, A.B., Engemann, S., Russel, D.E., Roark, M., Washington, S.L., Maxwell, M.M., Marsh, J.L., Thompson, L.M., Wanker, E.E., Young, A.B., Housman, D.E., Bates, G.P., Sherman, M.Y. and Kazantsev, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102
(3): 892-897.
18 January 2005
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler, H., Lalowski, M., Stelzl, U., Waelter, S., Stroedicke, M., Worm, U., Droege, A., Lindenberg, K.S., Knoblich, M., Haenig, C., Herbst, M., Suopanki, J., Scherzinger, E., Abraham, C., Bauer, B., Hasenbank, R., Fritzsche, A., Ludewig, A.H., Buessow, K., Coleman, S.H., Gutekunst, C.A., Landwehrmeyer, B.G., Lehrach, H. and Wanker, E.E.
Molecular Cell 15
(6): 853-865.
24 September 2004
The hunt for huntingtin function: interaction partners tell many different stories.
Harjes, P. and Wanker, E.E.
Trends in Biochemical Sciences 28
(8): 425-433.
August 2003
Polyglutamine fibrillogenesis: The pathway unfolds.
Ross, C.A., Poirier, M.A., Wanker, E.E. and Amzel, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(1): 1-3.
7 January 2003
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser, V., Engemann, S., Broecker, W., Dunkel, I., Boeddrich, A., Waelter, S., Nordhoff, E., Lurz, R., Schugardt, N., Rautenberg, S., Herhaus, C., Barnickel, G., Boettcher, H., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 99
(Suppl 4): 16400-16406.
10 December 2002
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
Calado, A., Treichel, N., Mueller, E.C., Otto, A. and Kutay, U.
EMBO Journal 21
(22): 6216-6224.
15 November 2002
EcoRII: a restriction enzyme evolving recombination functions.
Muecke, M., Grelle, G., Behlke, J., Kraft, R., Krueger, D.H. and Reuter, M.
EMBO Journal 21
(19): 5262-5268.
1 October 2002
Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC.
Li, P.F., Li, J.C., Mueller, E.C., Otto, A., Dietz, R. and von Harsdorf, R.
Molecular Cell 10
(2): 247-258.
August 2002
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques.
Perutz, M.F., Pope, B.J., Owen, D., Wanker, E.E. and Scherzinger, E.
Proceedings of the National Academy of Sciences of the United States of America 99
(8): 5596-5600.
16 April 2002
Hip1 and Hippi participate in a novel cell death-signaling pathway.
Wanker, E.E.
Developmental Cell 2
(2): 126-128.
February 2002
CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H., Naegler, K., Schumacher, S., Goeritz, C., Mueller, E.C., Otto, A. and Pfrieger, F.W.
Science 294
(5545): 1354-1357.
9 November 2001
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Bech-Otschir, D., Kraft, R., Huang, X.H., Henklein, P., Kapelari, B., Pollmann, C. and Dubiel, W.
EMBO Journal 20
(7): 1630-1639.
1 January 2001
Importin 13: a novel mediator of nuclear import and export.
Mingot, J.M., Kostka, S., Kraft, R., Hartmann, E. and Goerlich, D.
EMBO Journal 20
: 3685-3694.
1 January 2001
Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
Urlaub, H., Raker, V.A., Kostka, S. and Luehrmann, R.
EMBO Journal 20
(1-2): 187-196.
1 January 2001
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Lipowsky, G., Bischoff, F.R., Schwarzmaier, P., Kraft, R., Kostka, S., Hartmann, E., Kutay, U. and Goerlich, D.
EMBO Journal 19
: 4362-4371.
15 August 2000
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R.A.
Nature 397
(6716): 263-266.
21 January 1999
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.
Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumedey, R., Schade, R., Gordon, C., Naumann, M. and Dubiel, W.
FASEB Journal 12
(6): 469-478.
1 April 1998
Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation.
Schumacher, S., Volkmer, H., Buck, F., Otto, A., Tarnok, A., Roth, S. and Rathjen, F.G.
Journal of Cell Biology 136
(4): 895-906.
24 February 1997
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
Kutay, U., Bischoff, F.R., Kostka, S., Kraft, R. and Goerlich, D.
Cell 90
: 1061-1071.
1 January 1997
Welfle, Heinz
Helicobacter exploits integrin for type IV secretion and kinase activation.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J.M., Sewald, N., Koenig, W. and Backert, S.
Nature 449
(7164): 862-866.
18 October 2007
A synthetic mimic of a discontinuous binding site on interleukin-10.
Reineke, U., Sabat, R., Misselwitz, R., Welfle, H., Volk, H.D. and Schneider-Mergener, J.
Nature Biotechnology 17
: 271-275.
1 March 1999
Wilck, Nicola (ECRC)
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15
(1): 2788.
30 March 2024
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119
(6): 1441-1452.
May 2023
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F., Hamad, I., Arroyo Hornero, R., Geisberger, S., Roels, J., Van Zeebroeck, L., Dyczko, A., van Gisbergen, M.W., Kurniawan, H., Wagner, A., Yosef, N., Weiss, S.N.Y., Schmetterer, K.G., Schröder, A., Krampert, L., Haase, S., Bartolomaeus, H., Hellings, N., Saeys, Y., Dubois, L.J., Brenner, D., Kempa, S., Hafler, D.A., Stegbauer, J., Linker, R.A., Jantsch, J., Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35
(2): 299-315.
7 February 2023
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33
(12): 2259-2275.
December 2022
Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Gawałko, M., Agbaedeng, T.A., Saljic, A., Mueller, D.N., Wilck, N., Schnabel, R., Penders, J., Rienstra, M., van Gelder, I., Jespersen, T., Schotten, U., Crijns, H.J.G.M., Kalman, J.M., Sanders, P., Nattel, S., Dobrev, D. and Linz, D.
Cardiovascular Research 118
(11): 2415–2427.
July 2022
Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144
(2): 144-158.
13 July 2021
The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K. and Muller, D.N.
Circulation Research 128
(7): 934-950.
2 April 2021
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12
(1): 1970.
30 March 2021
Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117
(3): 863-875.
1 March 2021
Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H., Avery, E.G., Bartolomaeus, T.U.P., Kozhakhmetov, S., Zhumadilov, Z., Müller, D.N., Wilck, N., Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116
(7): 1252-1253.
June 2020
Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A., Wiesemann, S., Golic, M., Balogh, A., Marko, L., Rakova, N., Wilck, N., Blaszczyk, E., Lim, C., Weiss, S., Kräker, K., Haase, N., Frolova, A., Jørgensen, J.S., Daub, S., Mueller, D.N., Herse, F., Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13
(5): 1291-1293.
May 2020
B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116
(5): 1059-1070.
1 April 2020
Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K., Jung, M., Foinquinos, A., San José, G., Beaumont, J., Bock, K., Grote-Levi, L., Xiao, K., Bär, C., Pfanne, A., Just, A., Zimmer, K., Ngoy, S., López, B., Ravassa, S., Samolovac, S., Janssen-Peters, H., Remke, J., Scherf, K., Dangwal, S., Piccoli, M.T., Kleemiss, F., Kreutzer, F.P., Kenneweg, F., Leonardy, J., Hobuß, L., Santer, L., Do, Q.T., Geffers, R., Braesen, J.H., Schmitz, J., Brandenberger, C., Müller, D.N., Wilck, N., Kaever, V., Bähre, H., Batkai, S., Fiedler, J., Alexander, K.M., Wertheim, B.M., Fisch, S., Liao, R., Diez, J., González, A. and Thum, T.
Circulation 141
(9): 751-767.
3 March 2020
The role of sodium in modulating immune cell function.
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H. and Müller, D.N.
Nature Reviews Nephrology 15
(9): 546-558.
September 2019
Sodium in the microenvironment regulates immune responses and tissue homeostasis.
Müller, D.N., Wilck, N., Haase, S., Kleinewietfeld, M. and Linker, R.A.
Nature Reviews Immunology 19
(4): 243-254.
April 2019
Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139
(11): 1407-1421.
12 March 2019
Willnow, Thomas E.
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P.L., Schmidt, V., Madsen, L.S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M.N., Romero-Ramos, M., Holm, C.K., Andersen, G.R., Zhao, H., Schuck, P., Nygaard, J.V., Sutherland, D.S., Eskildsen, S.F., Willnow, T.E., Brooks, D.J. and Vorup-Jensen, T.
Nature Communications 15
(1): 1224.
9 February 2024
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83
(6): 994-1011.e18.
16 March 2023
VPS10P domain receptors: sorting out brain health and disease.
Malik, A.R. and Willnow, T.E.
Trends in Neurosciences 43
(11): 870-885.
November 2020
Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A., Carlo-Spiewok, A.S., Malik, A.R., Rothe, M., Schipke, C.G., Peters, O., Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 16
(9): 1248-1258.
September 2020
Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J., Marczenke, M., Rudolph, I.M., Nielsen, R., Storm, T., Ilsoe Christensen, E., Diecke, S., Emma, F. and Willnow, T.E.
Kidney International 98
(1): 159-167.
July 2020
Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas.
Ruzittu, S., Willnow, D. and Spagnoli, F.M.
Cold Spring Harbor Perspectives in Biology 12
(7): a035626.
July 2020
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A., Kang, M.C., Yang, W.M., Hwang, W.M., Kim, S.S., Hong, S.H., Heo, J.I., Vijyakumar, A., Pereira de Moura, L., Uner, A., Huang, H., Lee, S.H., Lima, I.S., Park, K.S., Kim, M.S., Dagon, Y., Willnow, T.E., Aroda, V., Ciaraldi, T.P., Henry, R.R. and Kim, Y.B.
Nature Communications 11
(1): 2024.
24 April 2020
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y., Zhao, Y., Jiang, L.L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J.C., Zhu, B., Masliah, E., Willnow, T.E., Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214
(12): 3669-3685.
4 December 2017
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20
(8): 1096-1103.
August 2017
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S., Bolcho, U., Molgaard, S., Bøggild, S., Vaegter, C.B., Smith, A.H., Nieto-Gonzalez, J.L., Ovesen, P.L., Pedersen, L.F., Fjorback, A.N., Kjolby, M., Login, H., Holm, M.M., Andersen, O.M., Nyengaard, J.R., Willnow, T.E., Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21
(12): 1740-1751.
December 2016
Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
Andersen, O.M., Rudolph, I.M. and Willnow, T.E.
Acta Neuropathologica 132
(5): 653-665.
November 2016
Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R., Fast, E.M., Solaimani, P., Knezevic, K., Eliades, A., Patel, R., Thambyrajah, R., Unnikrishnan, A., Thoms, J., Beck, D., Vink, C.S., Smith, A., Wong, J., Shepherd, M., Kent, D., Roychoudhuri, R., Paul, F., Klippert, J., Hammes, A., Willnow, T., Göttgens, B., Dzierzak, E., Zon, L.I., Lacaud, G., Kouskoff, V. and Pimanda, J.E.
Blood 128
(15): 1928-1939.
13 October 2016
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M.N., Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126
(7): 2706-2720.
1 July 2016
Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S.M.A., van het Hof, B., Gollasch, M., Drexhage, J.A.R., Reijerkerk, A., Meij, I.C., Mebius, R., Willnow, T.E., Müller, D., Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128
(2): 267-277.
August 2014
SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.
Glerup, S., Olsen, D., Vaegter, C.B., Gustafsen, C., Sjoegaard, S.S., Hermey, G., Kjolby, M., Molgaard, S., Ulrichsen, M., Boggild, S., Skeldal, S., Fjorback, A.N., Nyengaard, J.R., Jacobsen, J., Bender, D., Bjarkam, C.R., Sørensen, E.S., Füchtbauer, E.M., Eichele, G., Madsen, P., Willnow, T.E., Petersen, C.M. and Nykjaer, A.
Neuron 82
(5): 1074-87.
4 June 2014
Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S., Takagi-Niidome, S., Liao, F., Carlo, A.S., Schmidt, V., Burgert, T., Kitago, Y., Füchtbauer, E.M., Füchtbauer, A., Holtzman, D.M., Takagi, J. and Willnow, T.E.
Science Translational Medicine 6
(223): 223ra20.
12 February 2014
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37
(5): 854-866.
16 November 2012
Sortilin: a receptor to regulate neuronal viability and function.
Nykjaer, A. and Willnow, T.E.
Trends in Neurosciences 35
(4): 261-270.
April 2012
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A., Christa, A., Kur, E., Lioubinski, O., Bachmann, S., Willnow, T.E. and Hammes, A.
Developmental Cell 22
(2): 268-278.
14 February 2012
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia.
Stuiver, M., Lainez, S., Will, C., Terryn, S., Guenzel, D., Debaix, H., Sommer, K., Kopplin, K., Thumfart, J., Kampik, N.B., Querfeld, U., Willnow, T.E., Nemec, V., Wagner, C.A., Hoenderop, J.G., Devuyst, O., Knoers, N.V., Bindels, R.J., Meij, I.C. and Mueller, D.
American Journal of Human Genetics 88
(3): 333-343.
11 March 2011
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B., Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14
(1): 54-61.
January 2011
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby, M., Andersen, O.M., Breiderhoff, T., Fjorback, A.W., Pedersen, K.M., Madsen, P., Jansen, P., Heeren, J., Willnow, T.E. and Nykjaer, A.
Cell Metabolism 12
(3): 213-223.
8 September 2010
PET imaging of leptin biodistribution and metabolism in rodents and primates.
Ceccarini, G., Flavell, R.R., Butelman, E.R., Synan, M., Willnow, T.E., Bar-Dagan, M., Goldsmith, S.J., Kreek, M.J., Kothari, P., Vallabhajosula, S., Muir, T.W. and Friedman, J.M.
Cell Metabolism 10
(2): 148-159.
6 August 2009
VPS10P-domain receptors - regulators of neuronal viability and function.
Willnow, T.E., Petersen, C.M. and Nykjaer, A.
Nature Reviews Neuroscience 9
(12): 899-909.
December 2008
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10
(11): 1449-1457.
November 2007
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Rogaeva, E., Meng, Y., Lee, J.H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C.T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K.L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L.A., Cuenco, K.T., Green, R.C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R.P., Inzelberg, R., Hampe, W., Bujo, H., Song, Y.Q., Andersen, O.M., Willnow, T.E., Graff-Radford, N., Petersen, R.C., Dickson, D., Der, S.D., Fraser, P.E., Schmitt-Ulms, G., Younkin, S., Mayeux, R., Farrer, L.A. and St George-Hyslop, P.
Nature Genetics 39
(2): 168-177.
February 2007
Lipoprotein receptors in Alzheimer's disease.
Andersen, O.M. and Willnow, T.E.
Trends in Neurosciences 29
(12): 687-694.
December 2006
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Donath, S., Li, P., Willenbockel, C., Al-Saadi, N., Gross, V., Willnow, T.E., Bader, M., Martin, U., Bauersachs, J., Wollert, K.C., Dietz, R. and von Harsdorf, R.
Circulation 113
(9): 1203-1212.
7 March 2006
Response: Cellular uptake of sex steroid hormones.
Willnow, T.E. and Nykjaer, A.
Cell 124
(3): 456-457.
10 February 2006
Role of endocytosis in cellular uptake of sex steroids.
Hammes, A., Andreassen, T.K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F.J., Luppa, P.B., Nykjaer, A. and Willnow, T.E.
Cell 122
(5): 751-762.
9 September 2005
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13461-13466.
7 September 2005
Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A., Lee, R., Teng, K.K., Jansen, P., Madsen, P., Nielsen, M.S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T.E., Hempstead, B.L. and Petersen, C.M.
Nature 427
(6977): 843-848.
26 February 2004
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release.
Lisi, S., Pinchera, A., McCluskey, R.T., Willnow, T.E., Refetoff, S., Marcocci, C., Vitti, P., Menconi, F., Grasso, L., Luchetti, F., Collins, A.B. and Marino, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(25): 14858-14863.
1 January 2003
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Nykjaer, A. and Willnow, T.E.
Trends in Cell Biology 12
(6): 273-280.
1 June 2002
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki, R., Fyfe, J., Verroust, P.J., Jacobsen, C., Dautry-Varsat, A., Gburek, J., Willnow, T.E., Christensen, E.I. and Moestrup, S.K.
Proceedings of the National Academy of Sciences of the United States of America 98
(22): 12491-12496.
1 January 2001
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3.
Nykjaer, A., Fyfe, J.C., Kozyraki, R., Leheste, J.R., Jacobsen, C., Nielsen, M.S., Verroust, P.J., Aminoff, M., de la Chapelle, A., Moestrup, S.K., Ray, R., Gliemann, J., Willnow, T.E. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13895-13900.
1 January 2001
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn, H., Fyfe, J.C., Jacobsen, C., Mounier, F., Verroust, P.J., Orskov, H., Willnow, T.E., Moestrup, S.K. and Christensen, E.I.
Journal of Clinical Investigation 105
(10): 1353-1361.
May 2000
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3.
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I. and Willnow, T.E.
Cell 96
(4): 507-515.
19 February 1999
Cholesterol, hedgehog and embryogenesis.
Herz, J., Willnow, T.E. and Farese, R.V.
Nature Genetics 15
(2): 123-124.
February 1997
Wittmann-Liebold, Brigitte
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R.A.
Nature 397
(6716): 263-266.
21 January 1999
Woehler, Andrew (BIMSB)
MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.
Mertens, T.F., Liebheit, A.T., Ehl, J., Köhler, R., Rakhymzhan, A., Woehler, A., Katthän, L., Ebel, G., Liublin, W., Kasapi, A., Triantafyllopoulou, A., Schulz, T.J., Niesner, R.A. and Hauser, A.E.
Nature Communications 15
(1): 1764.
26 February 2024
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20
(10): 1544-1552.
October 2023
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A., Wyler, E., Pentimalli, T.M., Legnini, I., Oliveras Martinez, A., Glažar, P., Loewa, A., Kim, S.J., Kaufer, B.B., Woehler, A., Landthaler, M. and Rajewsky, N.
Nature Microbiology 8
(7): 1252-1266.
July 2023
Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14
(1): 3025.
25 May 2023
A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
Huljev, K., Shamipour, S., Pinheiro, D., Preusser, F., Steccari, I., Sommer, C.M., Naik, S. and Heisenberg, C.P.
Developmental Cell 58
(7): 582-596.e7.
10 April 2023
RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
Bahry, E., Breimann, L., Zouinkhi, M., Epstein, L., Kolyvanov, K., Mamrak, N., King, B., Long, Xi, Harrington, K.I.S., Lionnet, T. and Preibisch, S.
Nature Methods 19
(12): 1563-1567.
December 2022
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D., Lindberg, E.L., Maatz, H., Miranda, A.M.A., Viveiros, A., Shvetsov, N., Gärtner, A., Nadelmann, E.R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D.M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J.M., Barnett, S.N., Brown, K., Buchan, R.J., Chowdhury, R.A., Constantinou, C., Cranley, J., Felkin, L.E., Fox, H., Ghauri, A., Gummert, J., Kanda, M., Li, R., Mach, L., McDonough, B., Samari, S., Shahriaran, F., Yapp, C., Stanasiuk, C., Theotokis, P.I., Theis, F.J., van den Bogaerdt, A., Wakimoto, H., Ware, J.S., Worth, C.L., Barton, P.J.R., Lee, Y.A., Teichmann, S.A., Milting, H., Noseda, M., Oudit, G.Y., Heinig, M., Seidman, J.G., Hubner, N. and Seidman, C.E.
Science 377
(6606): eabo1984.
5 August 2022
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.
Schepanski, S., Chini, M., Sternemann, V., Urbschat, C., Thiele, K., Sun, T., Zhao, Y., Poburski, M., Woestemeier, A., Thieme, M.T., Zazara, D.E., Alawi, M., Fischer, N., Heeren, J., Vladimirov, N., Woehler, A., Puelles, V.G., Bonn, S., Gagliani, N., Hanganu-Opatz, I.L. and Arck, P.C.
Nature Communications 13
(1): 4571.
5 August 2022
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S., Gimber, N., Deuschel, D., Stuhlmann, T., Puchkov, D., Farsi, Z., Ludwig, C.F., Novarino, G., López-Cayuqueo, K.I., Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39
(9): e103358.
4 May 2020
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
Wolf, Jana
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597
(7874): 87-91.
2 September 2021
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y., Lahmann, I., Baum, K., Shimojo, H., Mourikis, P., Wolf, J., Kageyama, R. and Birchmeier, C.
Nature Communications 12
(1): 1318.
26 February 2021
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6
: 7367.
14 July 2015
A multiplexed NMR-reporter approach to measure cellular kinase and phosphatase activities in real-time.
Thongwichian, R., Kosten, J., Benary, U., Rose, H.M., Stuiver, M., Theillet, F.X., Dose, A., Koch, B., Yokoyama, H., Schwarzer, D., Wolf, J. and Selenko, P.
Journal of the American Chemical Society 137
(20): 6468-6471.
27 May 2015
Global quantification of mammalian gene expression control.
Schwanhaeusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W. and Selbach, M.
Nature 473
(7347): 337-342.
19 May 2011
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Wolf, Susanne
Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B.D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K.P.L., Flüh, C., Kälin, R.E. and Glass, R.
Cell Reports Medicine 5
(8): 101658.
20 August 2024
Microglia states and nomenclature: A field at its crossroads.
Paolicelli, R.C., Sierra, A., Stevens, B., Tremblay, M.E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G.C., Butovsky, O., Carson, M.J., Castellano, B., Colonna, M., Cowley, S.A., Cunningham, C., Davalos, D., De Jager, P.L., de Strooper, B., Denes, A., Eggen, B.J.L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C.K., Gokce, O., Gomez-Nicola, D., González, B., Gordon, S., Graeber, M.B., Greenhalgh, A.D., Gressens, P., Greter, M., Gutmann, D.H., Haass, C., Heneka, M.T., Heppner, F.L., Hong, S., Hume, D.A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B.W., Miron, V.E., Molofsky, A.V., Monje, M., Mracsko, E., Nadjar, A., Neher, J.J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V.H., Popovich, P.G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R.M., Salter, M.W., Schaefer, A., Schafer, D.P., Schwartz, M., Simons, M., Smith, C.J., Streit, W.J., Tay, T.L., Tsai, L.H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S.A., Wu, L.J. and Wyss-Coray, T.
Neuron 110
(21): 3458-3483.
2 November 2022
Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A., Haage, V., Yang, S., Wegner, S., Ersoy, B., Ugursu, B., Rex, A., Kronenberg, G., Gertz, K., Endres, M., Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91
: 89-104.
January 2021
Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135
(4): 551.
April 2018
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357
(6357): eaam8526.
22 September 2017
Microglia in physiology and disease.
Wolf, S.A., Boddeke, H.W.G.M. and Kettenmann, H.
Annual Review of Physiology 79
: 619-643.
February 2017
Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Hoffmann, C.J., Harms, U., Rex, A., Szulzewsky, F., Wolf, S.A., Grittner, U., Lättig-Tünnemann, G., Sendtner, M., Kettenmann, H., Dirnagl, U., Endres, M. and Harms, C.
Circulation 131
(20): 1772-1782.
19 May 2015
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P.M., Wolf, S., Hoertnagl, H., Raine, C.S., Schneider-Stock, R., Nitsch, R. and Ullrich, O.
Neuron 49
(1): 67-79.
5 January 2006
Zampieri, Niccolo
Making sense of proprioception.
Santuz, A. and Zampieri, N.
Trends in Genetics 40
(1): 20-23.
January 2024
The making of a proprioceptor: a tale of two identities.
de Nooij, J.C. and Zampieri, N.
Trends in Neurosciences 46
(12): 1083-1094.
December 2023
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13
(1): 6867.
11 November 2022
Zenke, Martin
Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension.
Gratze, P., Dechend, R., Stocker, C., Park, J.K., Feldt, S., Shagdarsuren, E., Wellner, M., Gueler, F., Rong, S., Gross, V., Obst, M., Plehm, R., Alenina, N., Zenclussen, A., Titze, J., Small, K., Yokota, Y., Zenke, M., Luft, F.C. and Mueller, D.N.
Circulation 117
(20): 2645-2656.
20 May 2008
Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R., Janz, M., Mapara, M.Y., Lemke, B., Stirling, D., Doerken, B., Zenke, M. and Lentzsch, S.
Blood 105
(10): 3833-3840.
1 January 2005
Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker, C., Kirsch, R.D., Ju, X.S., Hieronymus, T., Gust, T.C., Kuhl, C., Jorgas, T., Kurz, S.M., Rose-John, S., Yokota, Y. and Zenke, M.
Nature Immunology 4
(4): 380-386.
April 2003
Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196
(5): 605-617.
2 September 2002
Ziebold, Ulrike
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment.
Vidal, V.P., Chaboissier, M.C., Luetzkendorf, S., Cotsarelis, G., Mill, P., Hui, C.C., Ortonne, N., Ortonne, J.P. and Schedl, A.
Current Biology 15
(15): 1340-1351.
9 August 2005
Zimmermann, Hanna (ECRC)
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.
Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J.I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J.P., Zimmermann, H.G., Oertel, F.C., Ringelstein, M., Brandt, A.U., Paul, F., Aktas, O., Hartung, H.P., Wiendl, H., Meuth, S.G. and Albrecht, P.
Nature Communications 15
(1): 5243.
19 June 2024
Zinzen, Robert (BIMSB)
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20
(10): 1544-1552.
October 2023
Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly.
Li, H., Janssens, J., De Waegeneer, M., Kolluru, S.S., Davie, K., Gardeux, V., Saelens, W., David, F.P.A., Brbić, M., Spanier, K., Leskovec, J., McLaughlin, C.N., Xie, Q., Jones, R.C., Brueckner, K., Shim, J., Tattikota, S.G., Schnorrer, F., Rust, K., Nystul, T.G., Carvalho-Santos, Zi., Ribeiro, C., Pal, S., Mahadevaraju, S., Przytycka, T.M., Allen, A.M., Goodwin, S.F., Berry, C.W., Fuller, M.T., White-Cooper, H., Matunis, E.L., DiNardo, S., Galenza, A., O'Brien, L.E., Dow, J.A.T., Jasper, H., Oliver, B., Perrimon, N., Deplancke, B., Quake, S.R., Luo, L. and Aerts, S.
Science 375
(6584): eabk2432.
4 March 2022
Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.
Glaser, L.V., Steiger, M., Fuchs, A., van Bömmel, A., Einfeldt, E., Chung, H.R., Vingron, M. and Meijsing, S.H.
Nucleic Acids Research 49
(21): 12178-12195.
2 December 2021
Oxidative metabolism drives immortalization of neural stem cells during tumorigenesis.
Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, M.D., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, R.P. and Knoblich, J.A.
Cell 182
(6): 1490-1507.
17 September 2020
Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M., Karabacak, A., Glahs, A., Kolundzic, E., Hirsekorn, A., Carda, A., Tursun, B., Zinzen, R.P., Lacadie, S.A. and Ohler, U.
Nature Communications 9
(1): 4472.
26 October 2018
High-throughput identification of RNA nuclear enrichment sequences.
Shukla, C.J., McCorkindale, A.L., Gerhardinger, C., Korthauer, K.D., Cabili, M.N., Shechner, D.M., Irizarry, R.A., Maass, P. and Rinn, J.L.
EMBO Journal 37
(6): e98452.
15 March 2018
McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes.
Hafez, D., Karabacak, A., Krueger, S., Hwang, Y.C., Wang, L.S., Zinzen, R.P. and Ohler, U.
Genome Biology 18
(1): 199.
26 October 2017
The Drosophila embryo at single-cell transcriptome resolution.
Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., Kocks, C., Rajewsky, N. and Zinzen, R.P.
Science 358
(6360): 194-199.
13 October 2017
Zipp, Frauke
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Sawcer, S., Hellenthal, G., Pirinen, M., Spencer, C.C., Patsopoulos, N.A., Moutsianas, L., Dilthey, A., Su, Z., Freeman, C., Hunt, S.E., Edkins, S., Gray, E., Booth, D.R., Potter, S.C., Goris, A., Band, G., Oturai, A.B., Strange, A., Saarela, J., Bellenguez, C., Fontaine, B., Gillman, M., Hemmer, B., Gwilliam, R., Zipp, F., Jayakumar, A., Martin, R., Leslie, S., Hawkins, S., Giannoulatou, E., D'alfonso, S., Blackburn, H., Boneschi, F.M., Liddle, J., Harbo, H.F., Perez, M.L., Spurkland, A., Waller, M.J., Mycko, M.P., Ricketts, M., Comabella, M., Hammond, N., Kockum, I., McCann, O.T., Ban, M., Whittaker, P., Kemppinen, A., Weston, P., Hawkins, C., Widaa, S., Zajicek, J., Dronov, S., Robertson, N., Bumpstead, S.J., Barcellos, L.F., Ravindrarajah, R., Abraham, R., Alfredsson, L., Ardlie, K., Aubin, C., Baker, A., Baker, K., Baranzini, S.E., Bergamaschi, L., Bergamaschi, R., Bernstein, A., Berthele, A., Boggild, M., Bradfield, J.P., Brassat, D., Broadley, S.A., Buck, D., Butzkueven, H., Capra, R., Carroll, W.M., Cavalla, P., Celius, E.G., Cepok, S., Chiavacci, R., Clerget-Darpoux, F., Clysters, K., Comi, G., Cossburn, M., Cournu-Rebeix, I., Cox, M.B., Cozen, W., Cree, B.A., Cross, A.H., Cusi, D., Daly, M.J., Davis, E., de Bakker, P.I., Debouverie, M., D'hooghe, M.B., Dixon, K., Dobosi, R., Dubois, B., Ellinghaus, D., Elovaara, I., Esposito, F., Fontenille, C., Foote, S., Franke, A., Galimberti, D., Ghezzi, A., Glessner, J., Gomez, R., Gout, O., Graham, C., Grant, S.F., Guerini, F.R., Hakonarson, H., Hall, P., Hamsten, A., Hartung, H.P., Heard, R.N., Heath, S., Hobart, J., Hoshi, M., Infante-Duarte, C., Ingram, G., Ingram, W., Islam, T., Jagodic, M., Kabesch, M., Kermode, A.G., Kilpatrick, T.J., Kim, C., Klopp, N., Koivisto, K., Larsson, M., Lathrop, M., Lechner-Scott, J.S., Leone, M.A., Leppa, V., Liljedahl, U., Bomfim, I.L., Lincoln, R.R., Link, J., Liu, J., Lorentzen, A.R., Lupoli, S., Macciardi, F., Mack, T., Marriott, M., Martinelli, V., Mason, D., McCauley, J.L., Mentch, F., Mero, I.L., Mihalova, T., Montalban, X., Mottershead, J., Myhr, K.M., Naldi, P., Ollier, W., Page, A., Palotie, A., Pelletier, J., Piccio, L., Pickersgill, T., Piehl, F., Pobywajlo, S., Quach, H.L., Ramsay, P.P., Reunanen, M., Reynolds, R., Rioux, J.D., Rodegher, M., Roesner, S., Rubio, J.P., Ruckert, I.M., Salvetti, M., Salvi, E., Santaniello, A., Schaefer, C.A., Schreiber, S., Schulze, C., Scott, R.J., Sellebjerg, F., Selmaj, K.W., Sexton, D., Shen, L., Simms-Acuna, B., Skidmore, S., Sleiman, P.M., Smestad, C., Sorensen, P.S., Sondergaard, H.B., Stankovich, J., Strange, R.C., Sulonen, A.M., Sundqvist, E., Syvanen, A.C., Taddeo, F., Taylor, B., Blackwell, J.M., Tienari, P., Bramon, E., Tourbah, A., Brown, M.A., Tronczynska, E., Casas, J.P., Tubridy, N., Corvin, A., Vickery, J., Jankowski, J., Villoslada, P., Markus, H.S., Wang, K., Mathew, C.G., Wason, J., Palmer, C.N., Wichmann, H.E., Plomin, R., Willoughby, E., Rautanen, A., Winkelmann, J., Wittig, M., Trembath, R.C., Yaouanq, J., Viswanathan, A.C., Zhang, H., Wood, N.W., Zuvich, R., Deloukas, P., Langford, C., Duncanson, A., Oksenberg, J.R., Pericak-Vance, M.A., Haines, J.L., Olsson, T., Hillert, J., Ivinson, A.J., De Jager, P.L., Peltonen, L., Stewart, G.J., Hafler, D.A., Hauser, S.L., McVean, G., Donnelly, P. and Compston, A.
Nature 476
(7359): 214-219.
10 August 2011
In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S.M., Luenstedt, S., Rinnenthal, J.L., Laube, G., Luche, H., Lehnardt, S., Fehling, H.J., Griesbeck, O. and Zipp, F.
Immunity 33
(3): 424-436.
24 September 2010
Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V., Vogt, J., Radbruch, H., Nitsch, R. and Zipp, F.
Trends in Neurosciences 33
(4): 202-210.
April 2010
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M., Steinman, L., Aktas, O. and Zipp, F.
Nature Medicine 15
(7): 788-793.
July 2009
Autoregulation of Th1-mediated inflammation by twist1.
Niesner, U., Albrecht, I., Janke, M., Doebis, C., Loddenkemper, C., Lexberg, M.H., Eulenburg, K., Kreher, S., Koeck, J., Baumgrass, R., Bonhagen, K., Kamradt, T., Enghard, P., Humrich, J.Y., Rutz, S., Schulze-Topphoff, U., Aktas, O., Bartfeld, S., Radbruch, H., Hegazy, A.N., Lohning, M., Baumgart, D.C., Duchmann, R., Rudwaleit, M., Haupl, T., Gitelman, I., Krenn, V., Gruen, J., Sieper, J., Zeitz, M., Wiedenmann, B., Zipp, F., Hamann, A., Janitz, M., Scheffold, A., Burmester, G.R., Chang, H.D. and Radbruch, A.
Journal of Experimental Medicine 205
(8): 1889-1901.
4 August 2008
Treatment-resistant chronic headaches and focal pachymeningitis in a 46-year-old man: a rare presentation of Wegener's granulomatosis.
Doerr, J., Elitok, S., Dieste, F.J., Vogel, H.P., Schneider, W., Wuerfel, J., Zipp, F. and Paul, F.
Lancet Neurology 7
(4): 368-372.
April 2008
Sirt1 contributes critically to the redox-dependent fate of neural progenitors.
Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schroeter, F., Ninnemann, O., Siegert, E., Bendix, I., Bruestle, O., Nitsch, R., Zipp, F. and Aktas, O.
Nature Cell Biology 10
(4): 385-394.
April 2008
TRAIL limits excessive host immune responses in bacterial meningitis.
Hoffmann, O., Priller, J., Prozorovski, T., Schulze-Topphoff, U., Baeva, N., Lunemann, J.D., Aktas, O., Mahrhofer, C., Stricker, S., Zipp, F. and Weber, J.R.
Journal of Clinical Investigation 117
(7): 2004-2013.
2 July 2007
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
Paul, F., Jarius, S., Aktas, O., Bluthner, M., Bauer, O., Appelhans, H., Franciotta, D., Bergamaschi, R., Littleton, E., Palace, J., Seelig, H.P., Hohlfeld, R., Vincent, A. and Zipp, F.
PLoS Medicine 4
(4): e133.
April 2007
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases.
Zipp, F. and Aktas, O.
Trends in Neurosciences 29
(9): 518-527.
September 2006
This list was generated on Sat Dec 21 08:25:42 2024 UTC.