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| Item Type: | Article |
|---|---|
| Title: | Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection |
| Creators: |
Pekayvaz, K.  ORCID: https://orcid.org/0000-0003-4040-650X, Leunig, A. ORCID: https://orcid.org/0000-0002-9179-9203, Kaiser, R. ORCID: https://orcid.org/0000-0003-1750-3395, Joppich, M. ORCID: https://orcid.org/0000-0002-6665-8951, Brambs, S., Janjic, A. ORCID: https://orcid.org/0000-0001-7180-5381, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Nixdorf, D. ORCID: https://orcid.org/0000-0003-1612-9952, Fumagalli, V., Schmidt, N. ORCID: https://orcid.org/0000-0002-3232-3491, Polewka, V., Anjum, A. ORCID: https://orcid.org/0000-0002-1976-4102, Knottenberg, V., Eivers, L., Wange, L.E. ORCID: https://orcid.org/0000-0002-3275-9156, Gold, C., Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Muenchhoff, M. ORCID: https://orcid.org/0000-0001-7016-0470, Hellmuth, J.C. ORCID: https://orcid.org/0000-0001-8409-3037, Scherer, C. ORCID: https://orcid.org/0000-0003-2816-6793, Rubio-Acero, R., Eser, T., Deák, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K. ORCID: https://orcid.org/0000-0002-4483-1557, Tomas, L. ORCID: https://orcid.org/0000-0001-9371-8721, Schulz, C. ORCID: https://orcid.org/0000-0002-8149-0747, Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M. ORCID: https://orcid.org/0000-0001-6143-4548, Iannacone, M. ORCID: https://orcid.org/0000-0002-9370-2671, Zimmer, R., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Hoelscher, M., Massberg, S. ORCID: https://orcid.org/0000-0001-7387-3986, Stark, K. ORCID: https://orcid.org/0000-0002-5369-8399 and Nicolai, L. ORCID: https://orcid.org/0000-0003-0776-5885
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| Abstract: | The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remains unclear. Here, we combine a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype associated with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies. |
| Keywords: | Ambulatory Care, COVID-19, Cytokines, Gene Expression Regulation, Gene Regulatory Networks, Interferons, Natural Killer Cells, Longitudinal Studies, Monocytes, Nasopharynx, SARS-CoV-2, T-Lymphocytes / Immunology |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 13 |
| Number: | 1 |
| Page Range: | 1018 |
| Date: | 23 February 2022 |
| Official Publication: | https://doi.org/10.1038/s41467-022-28508-0 |
| PubMed: | View item in PubMed |
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