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Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

Item Type:Article
Title:Parasympathetic neurons originate from nerve-associated peripheral glial progenitors
Creators Name:Dyachuk, V., Furlan, A., Shahidi, M.K., Giovenco, M., Kaukua, N., Konstantinidou, C., Pachnis, V., Memic, F., Marklund, U., Müller, T., Birchmeier, C., Fried, K., Ernfors, P. and Adameyko, I.
Abstract:The peripheral autonomic nervous system reaches far throughout the body and includes neurons of diverse functions, such as sympathetic and parasympathetic. We show that the parasympathetic system in mice--including trunk ganglia and the cranial ciliary, pterygopalatine, lingual, submandibular, and otic ganglia--arise from glial cells in nerves, not neural crest cells. The parasympathetic fate is induced in nerve-associated Schwann cell precursors at distal peripheral sites. We used multicolor Cre-reporter lineage tracing to show that most of these neurons arise from bi-potent progenitors that generate both glia and neurons. This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system.
Keywords:Basic Helix-Loop-Helix Transcription Factors, Neural Stem Cells, Neuroanatomical Tract-Tracing Techniques, Neurogenesis, Neuroglia, Neurons, Parasympathetic Ganglia, Parasympathetic Nervous System, Schwann Cells, SOXE Transcription Factors, Animals, Mice
Publisher:American Association for the Advancement of Science
Page Range:82-87
Date:4 July 2014
Official Publication:https://doi.org/10.1126/science.1253281
PubMed:View item in PubMed

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