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Developmental and functional heterogeneity of monocytes

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Item Type:Review
Title:Developmental and functional heterogeneity of monocytes
Creators Name:Guilliams, M., Mildner, A. and Yona, S.
Abstract:Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of multiple subsets generated through distinct developmental pathways with diverse functional specializations. Their fates under homeostatic conditions include the accumulation in peripheral reservoirs and the engraftment into certain resident macrophage pools. Under pathological conditions, monocytes acquire inflammatory effector functions, but can also develop regulatory properties essential for tissue repair. Importantly, monocytes recruited during inflammation are often functionally distinct from resident macrophages or conventional dendritic cells. Here we outline emerging concepts in monocyte heterogeneity, emergency monopoiesis, and trained immunity and discuss how these bring new perspectives to monocyte research.
Keywords:Cell Differentiation, Cell Movement, Dendritic Cells, Homeostasis, Immunological Models, Inflammation, Macrophages, Monocytes, Animals
Publisher:Cell Press
Page Range:595-613
Date:16 October 2018
Additional Information:Copyright © 2018. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Official Publication:https://doi.org/10.1016/j.immuni.2018.10.005
PubMed:View item in PubMed

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