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| Item Type: | Article |
|---|---|
| Title: | SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies |
| Creators: |
Reincke, S.M.  ORCID: https://orcid.org/0000-0002-8132-3527, Yuan, M. ORCID: https://orcid.org/0000-0001-9754-4503, Kornau, H.C. ORCID: https://orcid.org/0000-0003-4187-7549, Corman, V.M. ORCID: https://orcid.org/0000-0002-3605-0136, van Hoof, S., Sánchez-Sendin, E., Ramberger, M. ORCID: https://orcid.org/0000-0003-3082-6906, Yu, W. ORCID: https://orcid.org/0000-0002-4025-2646, Hua, Y., Tien, H. ORCID: https://orcid.org/0000-0001-7584-5989, Schmidt, M.L., Schwarz, T. ORCID: https://orcid.org/0000-0002-6054-4750, Jeworowski, L.M. ORCID: https://orcid.org/0000-0002-4159-4189, Brandl, S.E., Rasmussen, H.F. ORCID: https://orcid.org/0000-0002-6923-875X, Homeyer, M.A. ORCID: https://orcid.org/0000-0003-0630-3857, Stöffler, L. ORCID: https://orcid.org/0000-0003-4724-5112, Barner, M. ORCID: https://orcid.org/0000-0003-3448-7294, Kunkel, D. ORCID: https://orcid.org/0000-0002-0054-955X, Huo, S. ORCID: https://orcid.org/0000-0002-0119-7517, Horler, J., von Wardenburg, N. ORCID: https://orcid.org/0000-0003-0476-9813, Kroidl, I., Eser, T.M. ORCID: https://orcid.org/0000-0003-2682-9135, Wieser, A., Geldmacher, C., Hoelscher, M. ORCID: https://orcid.org/0000-0002-7642-1835, Gänzer, H. ORCID: https://orcid.org/0000-0003-0358-3689, Weiss, G. ORCID: https://orcid.org/0000-0003-0709-2158, Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, Prüss, H. ORCID: https://orcid.org/0000-0002-8283-7976, Wilson, I.A. ORCID: https://orcid.org/0000-0002-6469-2419 and Kreye, J. ORCID: https://orcid.org/0000-0003-2913-1015
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| Abstract: | SARS-CoV-2 Beta variant of concern (VOC) resists neutralization by major classes of antibodies from COVID-19 patients and vaccinated individuals. Here, serum of Beta-infected patients revealed reduced cross-neutralization of wildtype virus. From these patients, we isolated Beta-specific and cross-reactive receptor-binding domain (RBD) antibodies. The Beta-specificity results from recruitment of VOC-specific clonotypes and accommodation of mutations present in Beta and Omicron into a major antibody class that is normally sensitive to these mutations. The Beta-elicited cross-reactive antibodies share genetic and structural features with wildtype-elicited antibodies, including a public VH1-58 clonotype targeting the RBD ridge. These findings advance our understanding of the antibody response to SARS-CoV-2 shaped by antigenic drift with implications for design of next-generation vaccines and therapeutics. |
| Keywords: | Neutralizing Antibodies, Viral Antibodies, Antigenic Drift and Shift, COVID-19, Cross Reactions, Neutralization Tests, Protein Binding, Protein Domains, Protein Interaction Domains and Motifs, SARS-CoV-2, Coronavirus Spike Glycoprotein, Coronavirus Spike Coronavirus / Metabolism |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 375 |
| Number: | 6582 |
| Page Range: | 782-787 |
| Date: | 18 February 2022 |
| Official Publication: | https://doi.org/10.1126/science.abm5835 |
| PubMed: | View item in PubMed |
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