Physiological functions of intracellular protein degradation

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Item Type:	Review
Title:	Physiological functions of intracellular protein degradation
Creators:	McShane, E. ORCID: https://orcid.org/0000-0002-7806-2063 and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
Abstract:	While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial degradation systems were identified and found to be involved in a staggering number of biological functions. Here, we provide a global overview of the diverse roles of cellular protein degradation using seven categories: homeostasis, regulation, quality control, stoichiometry control, proteome remodeling, immune surveillance, and baseline turnover. Using selected examples, we outline how proteins are degraded and why this is functionally relevant.
Keywords:	Protein Degradation, Autophagy, Ubiquitin Proteasome System, Protein Quality Control
Source:	Annual Review of Cell and Developmental Biology
ISSN:	1081-0706
Publisher:	Annual Reviews
Volume:	38
Page Range:	241-262
Date:	October 2022
Official Publication:	https://doi.org/10.1146/annurev-cellbio-120420-091943
PubMed:	View item in PubMed

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