Helmholtz Gemeinschaft


Mapping the MHC class I spliced immunopeptidome of cancer cells

Item Type:Article
Title:Mapping the MHC class I spliced immunopeptidome of cancer cells
Creators Name:Liepe, J., Sidney, J., Lorenz, F.K.M., Sette, A. and Mishto, M.
Abstract:Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.
Keywords:Base Sequence, Breast Neoplasms, Colonic Neoplasms, MHC Class I Genes, Neoplasm Antigens, Peptides, Protein Splicing, Tumor Cell Line
Source:Cancer Immunology Research
Publisher:American Association for Cancer Research
Page Range:62-76
Date:January 2019
Official Publication:https://doi.org/10.1158/2326-6066.CIR-18-0424
External Fulltext:View full text on external repository or document server
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library