Choosing wisely - Preclinical test models in the era of precision medicine

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Item Type:	Review
Title:	Choosing wisely - Preclinical test models in the era of precision medicine
Creators:	Klinghammer, K. ORCID: https://orcid.org/0000-0001-6425-4833, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231 and Hoffmann, J. ORCID: https://orcid.org/0000-0003-3880-1658
Abstract:	Through the introduction of a steadily growing variety of preclinical test models drug development and biomarker research has advanced. Next to classical used 2D cell line cultures, tissue-slice cultures, 3D organoid cell cultures, genetically engineered mouse models, cell line derived mouse models and patient derived xenografts may be selected for a specific question. All models harbor advantages and disadvantages. This review focuses on the available preclinical test models, novel developments such as humanized mice and discusses for which question a particular model should be employed.
Keywords:	Preclinical Models, PDX, CDX, GEMMs, Tissue-Slice Cultures, Animals
Source:	Cancer Treatment Reviews
ISSN:	0305-7372
Publisher:	Elsevier
Volume:	55
Page Range:	36-45
Date:	April 2017
Official Publication:	https://doi.org/10.1016/j.ctrv.2017.02.009
PubMed:	View item in PubMed

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