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Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia

Item Type:Article
Title:Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia
Creators Name:Shalapour, S., Eckert, C., Seeger, K., Pfau, M., Prada, J., Henze, G., Blankenstein, T. and Kammertoens, T.
Abstract:Childhood acute lymphoblastic leukemia (ALL) is caused by malignant immature lymphocytes. Even though childhood ALL can be cured in a large number of patients, around 20% of the patients suffer a relapse after chemotherapy. The origin of the relapse is unclear at the present time. Given the high plasticity of cells, we searched for leukemia-associated genetic aberrations and immunoglobulin (IG) gene rearrangements in mesenchymal stem cells (MSC) from childhood B-cell precursor ALL patients. MSC from all ten ALL patients analyzed presented the chromosomal translocations that had been detected in leukemia cells (TEL-AML1, E2A-PBX1, or MLL rearrangement). The proportions of translocation-positive MSC varied between 10% and 54% depending on the patients and the time point of analysis. Leukemia-specific IG gene rearrangements were detected in the MSC from three ALL patients. The detection of leukemia-associated genetic aberrations in MSC indicates a clonal relationship between MSC and leukemia cells and suggests their involvement in the pathogenesis and/or pathophysiology of childhood ALL.
Keywords:Mesenchymal Stem Cells, Fusion Genes, Childhood Acute Lymphoblastic Leukemia, Chromosomal Translocations, IG Gene Rearrangements
Source:Journal of Molecular Medicine
Page Range:249-265
Date:March 2010
Official Publication:https://doi.org/10.1007/s00109-009-0583-8
PubMed:View item in PubMed

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