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Predicting novel RNA-RNA interactions

Item Type:Review
Title:Predicting novel RNA-RNA interactions
Creators Name:Meyer, I.M.
Abstract:The purpose of this article is to give a brief, yet concise overview of the current computational methods for predicting novel RNA-RNA interactions, that is interactions whose characteristic features we do not yet know. We start by briefly reviewing experimentally confirmed examples of RNA-RNA interactions before introducing computational methods for predicting RNA-RNA interactions. We will focus primarily on the interactions between different RNA molecules, that is trans RNA-RNA interactions, and will only discuss methods for predicting RNA structure, that is cis-only RNA-RNA interactions, where this helps to gain a better understanding. We conclude by discussing the merits of the different approaches and provide an outlook on probably and desirable future developments in the field.
Keywords:Molecular Models, Nucleic Acid Conformation, RNA
Source:Current Opinion in Structural Biology
Publisher:Current Biology
Page Range:387-393
Date:June 2008
Official Publication:https://doi.org/10.1016/j.sbi.2008.03.006
PubMed:View item in PubMed

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