Helmholtz Gemeinschaft


ICOS+Th cells produce distinct cytokines in different mucosal immune responses

Item Type:Article
Title:ICOS+Th cells produce distinct cytokines in different mucosal immune responses
Creators Name:Bonhagen, K., Liesenfeld, O., Stadecker, M.J., Hutloff, A., Erb, K., Coyle, A.J., Lipp, M., Kroczek, R.A. and Kamradt, T.
Abstract:T cell activation, differentiation and effector functions depend on signals delivered through the antigen-specific TCR and non-clonal costimulatory receptors on the T cell. Activated T cells express the inducible costimulator (ICOS). We examined the co-expression of ICOS with Th cytokines in mucosal immune responses. ICOS+CD4+ Th cells expressed strikingly different cytokines depending on the type of infection encountered and the cells' anatomical localization. In the Th2-dominated response to Schistosoma mansoni, ICOS expression of CD4+ cells isolated from the liver was strongly associated with the expression of IL-5, IL-10, IL-13, and T1/ST2, but not with the chemokine receptor CXCR5, a pattern consistent with Th2 effector cells. In the secondary lymphatic organs of schistosome-infected mice, ICOS expression was randomly correlated with Th2 effector-cytokines, but positively correlated with CXCR5 expression; a pattern consistent with follicular Th cells. In Th cells isolated from gut or liver of mice infected with Toxoplasma gondii, ICOS expression was positively correlated with IFN-γ production. Finally, in the severe combined immunodeficiency transfer colitis model, ICOS expression was strongly positively associated with IFN-γ and IL-2. Thus, ICOS appears to costimulate distinct effector functions in different immune responses, depending on factors such as the nature of the antigen encountered localization and chronicity of the immune response.
Keywords:Cell Surface Molecule, Mucosa, Parasitic Infection, T Lymphocyte, Th1/Th2 Cell, Animals, Mice
Source:European Journal of Immunology
Page Range:392-401
Date:February 2003
Official Publication:https://doi.org/10.1002/immu.200310013
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library