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| Item Type: | Article |
|---|---|
| Title: | Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells |
| Creators: |
Hammer, Q.  ORCID: https://orcid.org/0000-0003-2968-6061, Rückert, T., Borst, E.M., Dunst, J., Haubner, A., Durek, P., Heinrich, F., Gasparoni, G., Babic, M., Tomic, A., Pietra, G. ORCID: https://orcid.org/0000-0002-7080-531X, Nienen, M., Blau, I.W., Hofmann, J., Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424, Prinz, I. ORCID: https://orcid.org/0000-0002-8789-9578, Koenecke, C. ORCID: https://orcid.org/0000-0001-7025-1735, Hemmati, P., Babel, N., Arnold, R., Walter, J., Thurley, K., Mashreghi, M.F., Messerle, M. ORCID: https://orcid.org/0000-0002-1227-3933 and Romagnani, C. ORCID: https://orcid.org/0000-0002-5167-7463
|
| Abstract: | Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C(+) NK cells has remained unclear. Here we found that adaptive NKG2C(+) NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C(+) NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C(+) NK cell populations among HCMV-seropositive people. |
| Keywords: | Cytomegalovirus, Cytomegalovirus Infections, Natural Killer Cells, NK Cell Lectin-Like Receptor Subfamily C, Viral Proteins |
| Source: | Nature Immunology |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Volume: | 19 |
| Number: | 5 |
| Page Range: | 453-463 |
| Date: | May 2018 |
| Official Publication: | https://doi.org/10.1038/s41590-018-0082-6 |
| PubMed: | View item in PubMed |
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