Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions

Jeuthe, S.; Kemna, J.; Kemna, C.P.; Zocholl, D.; Klopfleisch, R.; Palme, R.; Kirschbaum, C.; Thoene-Reineke, C.; Kammertoens, T.

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions

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Item Type:	Article
Title:	Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions
Creators:	Jeuthe, S., Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441, Kemna, C.P., Zocholl, D., Klopfleisch, R., Palme, R. ORCID: https://orcid.org/0000-0001-9466-3662, Kirschbaum, C., Thoene-Reineke, C. and Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141
Abstract:	It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice.
Keywords:	B-Lymphocytes, Corticosterone, DNA-Binding Proteins, Infections, Interferon Receptors, Interferon-gamma, Kidney, Pain, SCID Mice, Signal Transduction, T-Lymphocytes, Testosterone, Animals, Mice
Source:	PLoS ONE
ISSN:	1932-6203
Publisher:	Public Library of Science
Volume:	15
Number:	9
Page Range:	e0239231
Date:	30 September 2020
Official Publication:	https://doi.org/10.1371/journal.pone.0239231
PubMed:	View item in PubMed

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