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| Item Type: | Article |
|---|---|
| Title: | TIM-3 and CEACAM1 do not interact in cis and in trans |
| Creators: |
De Sousa Linhares, A., Kellner, F.  ORCID: https://orcid.org/0000-0001-5931-3798, Jutz, S., Zlabinger, G.J. ORCID: https://orcid.org/0000-0002-7478-4173, Gabius, H.J., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Leitner, J. ORCID: https://orcid.org/0000-0002-7156-1759 and Steinberger, P. ORCID: https://orcid.org/0000-0001-6848-4097
|
| Abstract: | TIM-3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its role may therefore depend on the state of T cells and on the presence of interaction partners capable to perform functional pairing. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) has been proposed to bind TIM-3 and to regulate its function. Using a T cell reporter platform we confirmed CEACAM1-mediated inhibition, but CEACAM1 did not functionally engage TIM-3. TIM-3 and CEACAM1 coexpression was limited to a small subset of activated T cells. Moreover, results obtained in extensive binding studies were not in support of an interaction between TIM-3 and CEACAM1. Cytoplasmic sequences derived from TIM-3 induced inhibitory signaling in our human T cell reporter system. Our results indicate that TIM-3 functions are independent of CEACAM1 and that this receptor has the capability to promote inhibitory signaling pathways in human T cells. |
| Keywords: | CEACAM1, Coinhibition, Costimulation, T-Cell Activation, TIM-3 |
| Source: | European Journal of Immunology |
| ISSN: | 0014-2980 |
| Publisher: | Wiley |
| Volume: | 50 |
| Number: | 8 |
| Page Range: | 1126-1141 |
| Date: | August 2020 |
| Official Publication: | https://doi.org/10.1002/eji.201948400 |
| PubMed: | View item in PubMed |
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