Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

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Item Type:	Article
Title:	Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
Creators:	Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X, Pless, O. ORCID: https://orcid.org/0000-0002-1468-316X, Lappe, M., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623 and Kowenz-Leutz, E.
Abstract:	C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.
Keywords:	Transcription, Chromatin Remodeling, Differentiation, Histone Code, Post-Translational Modification, Signaling, Methylation, Animals
Source:	Transcription
ISSN:	2154-1264
Publisher:	Landes Bioscience
Volume:	2
Number:	1
Page Range:	3-8
Date:	January 2011
Official Publication:	https://doi.org/10.4161/trns.2.1.13510
PubMed:	View item in PubMed

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