Oligonucleotide library screening for identification of virus-specific T-cell receptors

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Item Type:	Article
Title:	Oligonucleotide library screening for identification of virus-specific T-cell receptors
Creators:	Welters, M.L., Stadler, S., Anastasopoulou, V., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Kammertöns, T. ORCID: https://orcid.org/0000-0003-3309-5141, Welters, C. ORCID: https://orcid.org/0000-0002-3098-9003 and Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128
Abstract:	We demonstrate an optimized oligonucleotide library-based approach for the identification of virus-reactive T-cell receptors using Epstein-Barr virus as an example. HEK293T served as antigen-presenting cells and were co-cultured with human T cells that were transduced with T-cell receptors in question. T-cell activation was detected by CD137 expression.
Keywords:	Epstein-Barr Virus, Oligonucleotide Library, Target Epitope Screening, T-Cell Immunology, TCR Antigen Identification
Source:	European Journal of Immunology
ISSN:	0014-2980
Publisher:	Wiley
Volume:	56
Number:	6
Page Range:	e2350908
Date:	June 2024
Official Publication:	https://doi.org/10.1002/eji.202350908
PubMed:	View item in PubMed

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