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2022

HDHL-INTIMIC: a European knowledge platform on food, diet, intestinal microbiomics, and human health.
Agamennone, V. and Abuja, P.M. and Basic, M. and De Angelis, M. and Gessner, A. and Keijser, B. and Larsen, M. and Pinart, M. and Nimptsch, K. and Pujos-Guillot, E. and Schlicht, K. and Sharon, I. and Untersmayr, E. and Laudes, M. and Pischon, T. and Bouwman, J.
Nutrients 14 (9): 1881. 29 April 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H. and Flórez, A.F. and Kreth, S. and Brückner, L.M. and Yildiz, U. and Gartlgruber, M. and Odoni, D.I. and Poschet, G. and Garbowicz, K. and Shao, C. and Klein, C. and Meier, J. and Zeisberger, P. and Nadler-Holly, M. and Ziehm, M. and Paul, F. and Burhenne, J. and Bell, E. and Shaikhkarami, M. and Würth, R. and Stainczyk, S.A. and Wecht, E.M. and Kreth, J. and Büttner, M. and Ishaque, N. and Schlesner, M. and Nicke, B. and Stresemann, C. and Llamazares-Prada, M. and Reiling, J.H. and Fischer, M. and Amit, I. and Selbach, M. and Herrmann, C. and Wölfl, S. and Henrich, K.O. and Höfer, T. and Trumpp, A. and Westermann, F.
Nature Cancer 3 (4): 471-485. 28 April 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. and Acemel, R.D. and Jedamzick, J. and Bolondi, A. and Cova, G. and Brieske, N. and Kühn, R. and Wittler, L. and Real, F.M. and Lupiáñez, D.G.
Nature Genetics July 2022

The role of respiratory microbiota in the protection against viral diseases: respiratory commensal bacteria as next-generation probiotics for COVID-19.
Andrade, B.G.N. and Cuadrat, R.R.C. and Tonetti, F.R. and Kitazawa, H. and Villena, J.
Bioscience of Microbiota, Food and Health 41 (3): 94-102. 1 July 2022

De novo whole genome assembly of the Roborovski dwarf hamster (Phodopus roborovskii) genome, an animal model for severe/critical COVID-19.
Andreotti, S. and Altmüller, J. and Quedenau, C. and Borodina, T. and Nouailles, G. and Teixeira Alves, L.G. and Landthaler, M. and Bieniara, M. and Trimpert, J. and Wyler, E.
Genome Biology and Evolution 14 (7): evac100. July 2022

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel, L.M. and Grishkovskaya, I. and Benedum, J. and Franke, V. and Polyansky, A. and Neudolt, A. and Wunder, A. and Zagrovic, B. and Akalin, A. and Djinovic-Carugo, K. and Slade, D.
bioRxiv : 2022.02.26.482114. 27 February 2022

LABKIT: labeling and segmentation toolkit for big image data.
Arzt, M. and Deschamps, J. and Schmied, C. and Pietzsch, T. and Schmidt, D. and Tomancak, P. and Haase, R. and Jug, F.
Frontiers in Computer Science 4 : 777728. 10 February 2022

De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway.
Asif, M. and Kaygusuz, E. and Shinawi, M. and Nickelsen, A. and Hsieh, T.C. and Wagle, P. and Budde, B. and Hochscherf, J. and Abdullah, U. and Höning, S. and Nienberg, C. and Lindenblatt, D. and Noegel, A.A. and Altmüller, J. and Thiele, H. and Motameny, S. and Fleischer, N. and Segal, I. and Pais, L. and Tinschert, S. and Samra, N.G. and Savatt, J.M. and Rudy, N.L. and De Luca, C. and Fortugno, P. and White, S.M. and Krawitz, P. and Hurst, A.C.E. and Niefind, K. and Jose, J. and Brancati, F. and Nürnberg, P. and Hussain, M.S.
Human Genetics and Genomics Advances 3 (3): 100111. 14 July 2022

A novel missense variant of SCN4A co-segregates with congenital essential tremor in a consanguineous Kurdish family.
Asif, M. and Mocanu, I.D. and Abdullah, U. and Höhne, W. and Altmüller, J. and Makhdoom, E.U.H. and Thiele, H. and Baig, S.M. and Nürnberg, P. and Graul-Neumann, L. and Hussain, M.S.
American Journal of Medical Genetics A 188 (4): 1251-1258. April 2022

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G. and Bartolomaeus, H. and Rauch, A. and Chen, C.Y. and N'Diaye, G. and Löber, U. and Bartolomaeus, T.U.P. and Fritsche-Guenther, R. and Rodrigues, A.F. and Yarritu, A. and Zhong, C. and Fei, L. and Tsvetkov, D. and Todiras, M. and Park, J.K. and Markó, L. and Maifeld, A. and Patzak, A. and Bader, M. and Kempa, S. and Kirwan, J.A. and Forslund, S.K. and Müller, D.N. and Wilck, N.
Cardiovascular Research : cvac121. 29 July 2022 (In Press)

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran, D. and Kochlamazashvili, G. and Pampaloni, N. P. and Sposini, S. and Shergill, J.K. and Lehmann, M. and Pashkova, N. and Schmidt, C. and Löwe, D. and Napieczynska, H. and Heuser, A. and Plested, A.J.R. and Perrais, D. and Piper, R.C. and Haucke, V. and Maritzen, T.
Science Advances 8 (21): eabl5032. 27 May 2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Balasubramanian, S. and Andreani, M. and Goncalves Andrade, J. and Saha, T. and Sundaravinayagam, D. and Garzón, J. and Zhang, W. and Popp, O. and Hiraga, S. and Rahjouei, A. and Rosen, D.B. and Mertins, P. and Chait, B.T. and Donaldson, A.D. and Di Virgilio, M.
eLife 11 : e75047. 13 April 2022

Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma.
Ballhausen, A. and Ben Hamza, A. and Welters, C. and Dietze, K. and Bullinger, L. and Rahn, H.P. and Hartmann, S. and Hansmann, M.L. and Hansmann, L.
Cancer Immunology Immunotherapy 10 August 2022 (In Press)

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S. and Bulatov, T. and Schmied, C. and Krämer, A. and Berger, B.T. and Oder, A. and Walker-Gray, R. and Kuschke, C. and Zühlke, K. and Eichhorst, J. and Lehmann, M. and Knapp, S. and Weston, J. and von Kries, J.P. and Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D. and Hörtenhuber, M. and Balwierz, P.J. and Zehnder, T. and Mukarram, A.K. and Nepal, C. and Várnai, C. and Hadzhiev, Y. and Jimenez-Gonzalez, A. and Li, N. and Wragg, J. and D'Orazio, F.M. and Relic, D. and Pachkov, M. and Díaz, N. and Hernández-Rodríguez, B. and Chen, Z. and Stoiber, M. and Dong, M. and Stevens, I. and Ross, S.E. and Eagle, A. and Martin, R. and Obasaju, O. and Rastegar, S. and McGarvey, A.C. and Kopp, W. and Chambers, E. and Wang, D. and Kim, H.R. and Acemel, R.D. and Naranjo, S. and Łapiński, M. and Chong, V. and Mathavan, S. and Peers, B. and Sauka-Spengler, T. and Vingron, M. and Carninci, P. and Ohler, U. and Lacadie, S.A. and Burgess, S.M. and Winata, C. and van Eeden, F. and Vaquerizas, J.M. and Gómez-Skarmeta, J.L. and Onichtchouk, D. and Brown, B.J. and Bogdanovic, O. and van Nimwegen, E. and Westerfield, M. and Wardle, F.C and Daub, C.O. and Lenhard, B. and Müller, F.
Nature Genetics 54 (7): 1037-1050. July 2022

PyZebraScope: an open-source platform for brain-wide neural activity imaging in zebrafish.
Barbara, R. and Kantharaju, M.N. and Haruvi, R. and Harrington, K. and Kawashima, T.
bioRxiv : bioRxiv. 15 February 2022

PyZebraScope: an open-source platform for brain-wide neural activity imaging in zebrafish.
Barbara, R. and Nagathihalli Kantharaju, M. and Haruvi, R. and Harrington, K. and Kawashima, T.
Frontiers in Cell and Developmental Biology 10 : 875044. 19 May 2022

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics.
Bayram, S. and Razzaque, Y.S. and Geisberger, S. and Pietzke, M. and Fürst, S. and Vechiatto, C. and Forbes, M. and Mastrobuoni, G. and Kempa, S.
Frontiers in Molecular Biosciences 9 : 859787. 12 August 2022

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics.
Baytek, G. and Blume, A. and Demirel, F.G. and Bulut, S. and Popp, O. and Mertins, P. and Tursun, B.
Biotechniques 73 (1): 5-17. June 2022

Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation.
Baytek, G. and Popp, O. and Mertins, P. and Tursun, B.
Biotechniques 72 (5): 175-184. May 2022

The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff, P. and Trinks, A. and Wiederspahn, J. and Obermayer, B. and Pett, J.P. and Jurmeister, P. and Elsner, A. and Dziodzio, T. and Rückert, J.C. and Neudecker, J. and Falk, C. and Beule, D. and Sers, C. and Morkel, M. and Horst, D. and Klauschen, F. and Blüthgen, N.
International Journal of Cancer 150 (12): 2058-2071. 15 June 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T. and Funck, K. and Wollweber, F. and Lisicki, E. and von der Malsburg, K. and von der Malsburg, A. and Laborenz, J. and Noel, J.K. and Hessenberger, M. and Jungbluth, S. and Bernert, C. and Kunz, S. and Riedel, D. and Lilie, H. and Jakobs, S. and van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

Full-length spatial transcriptomics reveals the unexplored isoform diversity of the myocardium post-MI.
Boileau, E. and Li, X. and Naarmann-de Vries, I.S. and Becker, C. and Casper, R. and Altmüller, J. and Leuschner, F. and Dieterich, C.
Frontiers in Genetics 13 : 912572. 22 July 2022

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways.
Braun, T. and Glass, M. and Wahnschaffe, L. and Otte, M. and Mayer, P. and Franitza, M. and Altmüller, J. and Hallek, M. and Hüttelmaier, S. and Schrader, A. and Herling, M.
Haematologica 107 (1): 187-200. January 2022

Noncanonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia.
Braun, T. and Stachelscheid, J. and Bley, N. and Oberbeck, S. and Otte, M. and Müller, T.A. and Wahnschaffe, L. and Glaß, M. and Ommer, K. and Franitza, M. and Gathof, B. and Altmüller, J. and Hallek, M. and Auguin, D. and Hüttelmaier, S. and Schrader, A. and Herling, M.
Cancer Research 82 (9): 1818-1831. 1 May 2022

Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T. and Himmerkus, N. and Meoli, L. and Fromm, A. and Sewerin, S. and Kriuchkova, N. and Nagel, O. and Ladilov, Y. and Krug, S. and Quintanova, C. and Stumpp, M. and Garbe-Schönberg, D. and Westernströer, U. and Merkel, C. and Brinkhus, M. and Altmüller, J. and Schweiger, M. and Mueller, D. and Mutig, K. and Morawski, M. and Halbritter, J. and Milatz, S. and Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33 (4): 699-717. April 2022

The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding.
Breimann, L. and Morao, A.K. and Kim, J. and Jimenez, D.S. and Maryn, N. and Bikkasani, K. and Carrozza, M.J. and Albritton, S.E. and Kramer, M. and Street, L.A. and Cerimi, K. and Schumann, V.F. and Bahry, E. and Preibisch, S. and Woehler, A. and Ercan, S.
Journal of Cell Science 135 (2): jcs258818. January 2022

WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly.
Bögershausen, N. and Krawczyk, H.E. and Jamra, R.A. and Lin, S.J. and Yigit, G. and Hüning, I. and Polo, A.M. and Vona, B. and Huang, K. and Schmidt, J. and Altmüller, J. and Luppe, J. and Platzer, K. and Dörgeloh, B.B. and Busche, A. and Biskup, S. and Mendes, M.I. and Smith, D.E.C. and Salomons, G.S. and Zibat, A. and Bültmann, E. and Nürnberg, P. and Spielmann, M. and Lemke, J.R. and Li, Y. and Zenker, M. and Varshney, G.K. and Hillen, H.S. and Kratz, C.P. and Wollnik, B.
Human Mutation 43 (10): 1454-1471. October 2022

Monitoring kidney size to interpret MRI-based assessment of renal oxygenation in acute pathophysiological scenarios.
Cantow, K. and Gladytz, T. and Millward, J.M. and Waiczies, S. and Niendorf, T. and Seeliger, E.
Acta Physiologica : e13868. 22 August 2022 (In Press)

Single cell‐ and spatial 'omics revolutionize physiology.
Conrad, T. and Altmüller, J.
Acta Physiologica : e13848. 2 June 2022

Combining callers improves the detection of copy number variants from whole-genome sequencing.
Coutelier, M. and Holtgrewe, M. and Jäger, M. and Flöttman, R. and Mensah, M.A. and Spielmann, M. and Krawitz, P. and Horn, D. and Beule, D. and Mundlos, S.
European Journal of Human Genetics 30 (2): 178-186. February 2022

Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases.
Damerau, A. and Kirchner, M. and Pfeiffenberger, M. and Ehlers, L. and Do Nguyen, D.H. and Mertins, P. and Bartek, B. and Maleitzke, T. and Palmowski, Y. and Hardt, S. and Winkler, T. and Buttgereit, F. and Gaber, T.
Metabolic Engineering 72 : 116-132. July 2022

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum, R. and Suwalski, P. and Asgharian, H. and Du Zhipei, G. and Lin, H. and Weiner, J. and Holtgrewe, M. and Thibeault, C. and Müller, M. and Wang, X. and Karadeniz, Z. and Saccomanno, J. and Doehn, J.M. and Hübner, R.H. and Hinzmann, B. and Blüher, A. and Siemann, S. and Telman, D. and Suttorp, N. and Witzenrath, M. and Hippenstiel, S. and Skurk, C. and Poller, W. and Sander, L.E. and Beule, D. and Kurth, F. and Guettouche, T. and Landmesser, U. and Berka, J. and Luong, K. and Rubelt, F. and Heidecker, B.
EClinicalMedicine 48 : 101438. June 2022

Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Degenhardt, F. and Ellinghaus, D. and Juzenas, S. and Lerga-Jaso, J. and Wendorff, M. and Maya-Miles, D. and Uellendahl-Werth, F. and ElAbd, H. and Rühlemann, M.C. and Arora, J. and Özer, O. and Lenning, O.B. and Myhre, R. and Vadla, M.S. and Wacker, E.M. and Wienbrandt, L. and Ortiz, A.B. and de Salazar, A. and Chercoles, A.G. and Palom, A. and Ruiz, A. and Garcia-Fernandez, A.E. and Blanco-Grau, A. and Mantovani, A. and Zanella, A. and Holten, A.R. and Mayer, A. and Bandera, A. and Cherubini, A. and Protti, A. and Aghemo, A. and Gerussi, A. and Ramirez, A. and Braun, A. and Nebel, A. and Barreira, A. and Lleo, A. and Teles, A. and Kildal, A.B. and Biondi, A. and Caballero-Garralda, A. and Ganna, A. and Gori, A. and Glück, A. and Lind, A. and Tanck, A. and Hinney, A. and Nolla, A.C. and Fracanzani, A.L. and Peschuck, A. and Cavallero, A. and Dyrhol-Riise, A.M. and Ruello, A. and Julià, A. and Muscatello, A. and Pesenti, A. and Voza, A. and Rando-Segura, A. and Solier, A. and Schmidt, A. and Cortes, B. and Mateos, B. and Nafria-Jimenez, B. and Schaefer, B. and Jensen, B. and Bellinghausen, C. and Maj, C. and Ferrando, C. and Horra, C. and Quereda, C. and Skurk, C. and Thibeault, C. and Scollo, C. and Herr, C. and Spinner, C.D. and Gassner, C. and Lange, C. and Hu, C. and Paccapelo, C. and Lehmann, C. and Angelini, C. and Cappadona, C. and Azuure, C. and Bianco, C. and Cea, C. and Sancho, C. and Hoff, D.A.L. and Galimberti, D. and Prati, D. and Haschka, D. and Jiménez, D. and Pestaña, D. and Toapanta, D. and Muñiz-Diaz, E. and Azzolini, E. and Sandoval, E. and Binatti, E. and Scarpini, E. and Helbig, E.T. and Casalone, E. and Urrechaga, E. and Paraboschi, E.M. and Pontali, E. and Reverter, E. and Calderón, E.J. and Navas, E. and Solligård, E. and Contro, E. and Arana-Arri, E. and Aziz, F. and Garcia, F. and Sánchez, F.G. and Ceriotti, F. and Martinelli-Boneschi, F. and Peyvandi, F. and Kurth, F. and Blasi, F. and Malvestiti, F. and Medrano, F.J. and Mesonero, F. and Rodriguez-Frias, F. and Hanses, F. and Müller, F. and Hemmrich-Stanisak, G. and Bellani, G. and Grasselli, G. and Pezzoli, G. and Costantino, G. and Albano, G. and Cardamone, G. and Bellelli, G. and Citerio, G. and Foti, G. and Lamorte, G. and Matullo, G. and Baselli, G. and Kurihara, H. and Neb, H. and My, I. and Kurth, I. and Hernández, I. and Pink, I. and Rojas, I. and Galván-Femenia, I. and Holter, J.C. and Afset, J.E. and Heyckendorf, J. and Kässens, J. and Damås, J.K. and Rybniker, J. and Altmüller, J. and Ampuero, J. and Martín, J. and Erdmann, J. and Banales, J.M. and Badia, J.R. and Dopazo, J. and Schneider, J. and Bergan, J. and Barretina, J. and Walter, J. and Quero, J.H. and Goikoetxea, J. and Delgado, J. and Guerrero, J.M. and Fazaal, J. and Kraft, J. and Schröder, J. and Risnes, K. and Banasik, K. and Müller, K.E. and Gaede, K.I. and Garcia-Etxebarria, K. and Tonby, K. and Heggelund, L. and Izquierdo-Sanchez, L. and Bettini, L.Rachele and Sumoy, L. and Sander, L.E. and Lippert, L.J. and Terranova, L. and Nkambule, L. and Knopp, L. and Gustad, L.T. and Garbarino, L. and Santoro, L. and Téllez, L. and Roade, L. and Ostadreza, M. and Intxausti, M. and Kogevinas, M. and Riveiro-Barciela, M. and Berger, M.M. and Schaefer, M. and Niemi, M.E.K. and Gutiérrez-Stampa, M.A. and Carrabba, M. and Figuera Basso, M.E. and Valsecchi, M.G. and Hernandez-Tejero, M. and Vehreschild, M.J.G.T and Manunta, M. and Acosta-Herrera, M. and D'Angiò, M. and Baldini, M. and Cazzaniga, M. and Grimsrud, M.M. and Cornberg, M. and Nöthen, M.M. and Marquié, M. and Castoldi, M. and Cordioli, M. and Cecconi, M. and D'Amato, M. and Augustin, M. and Tomasi, M. and Boada, M. and Dreher, M. and Seilmaier, M.J. and Joannidis, M. and Wittig, M. and Mazzocco, M. and Ciccarelli, M. and Rodríguez-Gandía, M. and Bocciolone, M. and Miozzo, M. and Ayo, N.I. and Blay, N. and Chueca, N. and Montano, N. and Braun, N. and Ludwig, N. and Marx, N. and Martínez, N. and Cornely, O.A. and Witzke, O. and Palmieri, O. and Faverio, P. and Preatoni, P. and Bonfanti, P. and Omodei, P. and Tentorio, P. and Castro, P. and Rodrigues, P.M. and España, P.P. and Hoffmann, P. and Rosenstiel, P. and Schommers, P. and Suwalski, P. and Pablo, R. and Ferrer, R. and Bals, R. and Gualtierotti, R. and Gallego-Durán, R. and Nieto, R. and Carpani, R. and Morilla, R. and Badalamenti, S. and Haider, S. and Ciesek, S. and May, S. and Bombace, S. and Marsal, S. and Pigazzini, S. and Klein, S. and Pelusi, S. and Wilfling, S. and Bosari, S. and Volland, S. and Brunak, S. and Raychaudhuri, S. and Schreiber, S. and Heilmann-Heimbach, S. and Aliberti, S. and Ripke, S. and Dudman, S. and Wesse, T. and Zheng, T. and Bahmer, T. and Eggermann, T. and Illig, T. and Brenner, T. and Pumarola, T. and Feldt, T. and Folseraas, T. and Cejudo, T.G. and Landmesser, U. and Protzer, U. and Hehr, U. and Rimoldi, V. and Monzani, V. and Skogen, V. and Keitel, V. and Kopfnagel, V. and Friaza, V. and Andrade, V. and Moreno, V. and Albrecht, W. and Peter, W. and Poller, W. and Farre, X. and Yi, X. and Wang, X. and Khodamoradi, Y. and Karadeniz, Z. and Latiano, A. and Goerg, S. and Bacher, P. and Koehler, P. and Tran, F. and Zoller, H. and Schulte, E.C. and Heidecker, B. and Ludwig, K.U. and Fernández, J. and Romero-Gómez, M. and Albillos, A. and Invernizzi, P. and Buti, M. and Duga, S. and Bujanda, L. and Hov, J.R. and Lenz, T.L. and Asselta, R. and Cid, R. and Valenti, L. and Karlsen, T.H. and Cáceres, M. and Franke, A.
Human Molecular Genetics 15 July 2022 (In Press)

A comparison of solvent-based extraction methods to assess the central carbon metabolites in mouse bone and muscle.
Dias, D.B. and Fritsche-Guenther, R. and Gutmann, F. and Duda, G.N. and Kirwan, J. and Poh, P.S.P.
Metabolites 12 (5): 453. 18 May 2022

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
Dieckmann, S. and Strohmeyer, A. and Willershäuser, M. and Maurer, S.F. and Wurst, W. and Marschall, S. and Hrabě de Angelis, M. and Kühn, R. and Worthmann, A. and Fuh, M.M. and Heeren, J. and Köhler, N. and Pauling, J.K. and Klingenspor, M.
American Journal of Physiology Endocrinology and Metabolism 322 (2): E85-E100. February 2022

Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J. and Baranovskii, A. and Ronen, J. and Uyar, B. and Franke, V. and Akalin, A.
Genome Biology 23 (1): 123. 30 May 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. and Pusch, F. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Guillan, K. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Meyer-Liesener, S. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Dubois, F. and Horst, D. and Schulte, J.H. and Spuler, S. and You, D. and Dela Cruz, F. and Kung, A.L. and Haase, K. and Di Virgilio, M. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Increase in mental disorders during the COVID-19 pandemic -- the role of occupational and financial strains. An analysis of the German National Cohort (NAKO) Study.
Dragano, N. and Reuter, M. and Peters, A. and Engels, M. and Schmidt, B. and Greiser, K.H. and Bohn, B. and Riedel-Heller, S. and Karch, A. and Mikolajczyk, R. and Krause, G. and Lang, O. and Panreck, L. and Rietschel, M. and Brenner, H. and Fischer, B. and Franzke, C.W. and Gastell, S. and Holleczek, B. and Jöckel, K.H. and Kaaks, R. and Keil, T. and Kluttig, A. and Kuß, O. and Legath, N. and Leitzmann, M. and Lieb, W. and Meinke-Franze, C. and Michels, K.B. and Obi, N. and Pischon, T. and Feinkohl, I. and Rospleszcz, S. and Schikowski, T. and Schulze, M.B. and Stang, A. and Völzke, H. and Willich, S.N. and Wirkner, K. and Zeeb, H. and Ahrens, W. and Berger, K.
Deutsches Arzteblatt International 119 (11): 179-187. 18 March 2022

Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry.
Dumont, M. and Weber-Lassalle, N. and Joly-Beauparlant, C. and Ernst, C. and Droit, A. and Feng, B.J. and Dubois, S. and Collin-Deschesnes, A.C. and Soucy, P. and Vallée, M. and Fournier, F. and Lemaçon, A. and Adank, M.A. and Allen, J. and Altmüller, J. and Arnold, N. and Ausems, M.G.E.M. and Berutti, R. and Bolla, M.K. and Bull, S. and Carvalho, S. and Cornelissen, S. and Dufault, M.R. and Dunning, A.M. and Engel, C. and Gehrig, A. and Geurts-Giele, W.R.R. and Gieger, C. and Green, J. and Hackmann, K. and Helmy, M. and Hentschel, J. and Hogervorst, F.B.L. and Hollestelle, A. and Hooning, M.J. and Horváth, J. and Ikram, M.A. and Kaulfuß, S. and Keeman, R. and Kuang, D. and Luccarini, C. and Maier, W. and Martens, J.W.M. and Niederacher, D. and Nürnberg, P. and Ott, C.E. and Peters, A. and Pharoah, P.D.P. and Ramirez, A. and Ramser, J. and Riedel-Heller, S. and Schmidt, G. and Shah, M. and Scherer, M. and Stäbler, A. and Strom, T.M. and Sutter, C. and Thiele, H. and van Asperen, C.J. and van der Kolk, L. and van der Luijt, R.B. and Volk, A.E. and Wagner, M. and Waisfisz, Q. and Wang, Q. and Wang-Gohrke, S. and Weber, B.H.F. and Devilee, P. and Tavtigian, S. and Bader, G.D. and Meindl, A. and Goldgar, D.E. and Andrulis, I.L. and Schmutzler, R.K. and Easton, D.F. and Schmidt, M.K. and Hahnen, E. and Simard, J.
Cancers 14 (14): 3363. 11 July 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T.L.. and Löhning, M.
Nature Communications 13 (1): 3059. 1 June 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. and Obermayer, B. and Weiner, J.M. and Zimmermann, K. and Anania, C. and Wagner, L.K. and Lyras, E.M. and Sapozhnikova, V. and Lara-Astiaso, D. and Prósper, F. and Lang, R. and Lupiáñez, D.G. and Beule, D. and Höpken, U.E. and Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J. and Jerke, U. and Eulenberg-Gustavus, C. and Kling, L. and Jenne, D.E. and Kirchner, M. and Mertins, P. and Bieringer, M. and Elitok, S. and Eckardt, K.U. and Schreiber, A. and Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation : e160089. 20 September 2022 (In Press)

The anti-glucocorticoid receptor antibody clone 5E4: raising awareness of unspecific antibody binding.
Ehlers, L. and Kirchner, M. and Mertins, P. and Strehl, C. and Buttgereit, F. and Gaber, T.
International Journal of Molecular Sciences 23 (9): 5049. 2 May 2022

Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J. and Berangi, M. and Yiannakou, C. and Silva, E. and Francischello, R. and Kuehne, A. and Niendorf, T. and Könneker, S. and Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15 : 382-391. September 2022

Development of a machine learning approach for local-scale ozone forecasting: application to Kennewick, WA.
Fan, K. and Dhammapala, R. and Harrington, K. and Lamastro, R. and Lamb, B. and Lee, Y.
Frontiers in Big Data 5 : 781309. 10 February 2022

One gene - two proteins: the C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria.
Fasciani, I. and Petragnano, F. and Wang, Z. and Edwards, R. and Telugu, N. and Pietrantoni, I. and Zauber, H. and Rossi, M. and Zabel, U. and Grieben, M. and Terzenidou, M.E. and Di Gregorio, J. and Pellegrini, C. and Santini, S. and Taddei, A.R. and Poehl, B. and Aringhieri, S. and Aloisi, G. and Marampon, F. and Roman, A. and Diecke, S. and Flati, V. and Giorgi, F. and Amicarelli, F. and Tobin, A.B. and Scarselli, M. and Tokatlidis, K. and Lohse, M.J. and Maggio, R. and Annibale, P.
bioRxiv : 2021.04.13.438299. 26 February 2022

Recent analytical approaches for the study of bioavailability and metabolism of bioactive phenolic compounds.
Fernández-Ochoa, Á. and Cádiz-Gurrea, M.L. and Fernández-Moreno, P. and Rojas-García, A. and Arráez-Román, D. and Segura-Carretero, A.
Molecules 27 (3): 777. 25 January 2022

Comprehensive identification of plant polyphenols by LC-MS.
Fernández-Ochoa, Á. and de la Luz Cádiz-Gurrea, M. and Segura Carretero, A.
In: Mass spectrometry for food analysis. Methods and Protocols in Food Science . Humana, New York, NY, 31-42. ISBN 978-1-0716-2106-6 26 June 2022

The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K. and Kirchner, M. and Mertins, P. and Zuberbier, T. and Babina, M.
Allergy 2 June 2022 (In Press)

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development.
Freitag, K. and Eede, P. and Ivanov, A. and Schneeberger, S. and Borodina, T. and Sauer, S. and Beule, D. and Heppner, F.
Research Square : rs.3.rs-1362379/v1. 28 February 2022

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model.
Freitag, K. and Sterczyk, N. and Wendlinger, S. and Obermayer, B. and Schulz, J. and Farztdinov, V. and Mülleder, M. and Ralser, M. and Houtman, J. and Fleck, L. and Braeuning, C. and Sansevrino, R. and Hoffmann, C. and Milovanovic, D. and Sigrist, S.J. and Conrad, T. and Beule, D. and Heppner, F.L. and Jendrach, M.
Journal of Neuroinflammation 19 (1): 172. 2 July 2022

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit.
Fritsche-Guenther, R. and Gloaguen, Y. and Eisenberger, A. and Kirwan, J.A.
Scientific Reports 12 (1): 7933. 13 May 2022

Identification and validation of small molecule analytes in mouse plasma by liquid chromatography–tandem mass spectrometry: A case study of misidentification of a short-chain fatty acid with a ketone body.
García-Rivera, Mariel A. and Fernández-Ochoa, Á. and Brüning, U. and Fritsche-Guenther, R. and Kirwan, J.A.
Talanta 242 : 123298. 15 May 2022

Cosmeceutical potential of major tropical and subtropical fruit by-products for a sustainable revalorization.
García-Villegas, A. and Rojas-García, A. and Villegas-Aguilar, M.C. and Fernández-Moreno, P. and Fernández-Ochoa, Á. and Cádiz-Gurrea, M.L. and Arráez-Román, D. and Segura-Carretero, A.
Antioxidants 11 (2): 203. 21 January 2022

Wie Kochsalz Mitochondrien beeinflusst.
Geisberger, S.
BIOspektrum 28 (4): 387-389. June 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Hillus, D. and Petrov, L. and Stein, J. and Dey, H.P. and Paclik, D. and Iwert, C. and Mülleder, M. and Aulakh, S.K. and Djudjaj, S. and Bülow, R.D. and Mei, H.E. and Schulz, A.R. and Thiel, A. and Hippenstiel, S. and Saliba, A.E. and Eils, R. and Lehmann, I. and Mall, M.A. and Stricker, S. and Röhmel, J. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer, B. and von Stillfried, S. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
Cell 185 (3): 493-512. 3 February 2022

The role of intraspinal sensory neurons in the control of quadrupedal locomotion.
Gerstmann, K. and Jurčić, N. and Blasco, E. and Kunz, S. and de Almeida Sassi, F. and Wanaverbecq, N. and Zampieri, N.
Current Biology 32 (11): 2442-2453. 6 June 2022

Rapid inflammasome activation is attenuated in post-myocardial infarction monocytes.
Giral, H. and Franke, V. and Moobed, M. and Müller, M.F. and Lübking, L. and James, D.M. and Hartung, J. and Kuschnerus, K. and Meteva, D. and Seppelt, C. and Jakob, P. and Klingenberg, R. and Kränkel, N. and Leistner, D. and Zeller, T. and Blankenberg, S. and Zimmermann, F. and Haghikia, A. and Lüscher, T.F. and Akalin, A. and Landmesser, U. and Kratzer, A.
Frontiers in Immunology 13 : 857455. 26 April 2022

Deep learning-assisted peak curation for large-scale LC-MS metabolomics.
Gloaguen, Y. and Kirwan, J.A. and Beule, D.
Analytical Chemistry 94 (12): 4930-4937. 29 March 2022

Isolation of neoantigen-specific human T cell receptors from different human and murine repertoires.
Grunert, C. and Willimsky, G. and Peuker, C.A. and Rhein, S. and Hansmann, L. and Blankenstein, T. and Blanc, E. and Beule, D. and Keller, U. and Pezzutto, A. and Busse, A.
Cancers 14 (7): 1842. 6 April 2022

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome.
Gönenc, I.I. and Elcioglu, N.H. and Martinez Grijalva, C. and Aras, S. and Großmann, N. and Praulich, I. and Altmüller, J. and Kaulfuß, S. and Li, Y. and Nürnberg, P. and Burfeind, P. and Yigit, G. and Wollnik, B.
Clinical Genetics 101 (5-6): 559-564. May 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G. and Conlon, T.M. and Jeridi, A. and Kim, R. and Ertüz, Z. and Lang, N.J. and Ansari, M. and Novikova, M. and Jiang, D. and Strunz, M. and Gaianova, M. and Hollauer, C. and Gabriel, C. and Angelidis, I. and Doll, S. and Pestoni, J.C. and Edelmann, S.L. and Kohlhepp, M.S. and Guillot, A. and Bassler, K. and Van Eeckhoutte, H.P. and Kayalar, Ö. and Konyalilar, N. and Kanashova, T. and Rodius, S. and Ballester-López, C. and Genes Robles, C.M. and Smirnova, N. and Rehberg, M. and Agarwal, C. and Krikki, I. and Piavaux, B. and Verleden, S.E. and Vanaudenaerde, B. and Königshoff, M. and Dittmar, G. and Bracke, K.R. and Schultze, J.L. and Watz, H. and Eickelberg, O. and Stoeger, T. and Burgstaller, G. and Tacke, F. and Heissmeyer, V. and Rinkevich, Y. and Bayram, H. and Schiller, H.B. and Conrad, M. and Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Hahn, T. and Ernsting, J. and Winter, N.R. and Holstein, V. and Leenings, R. and Beisemann, M. and Fisch, L. and Sarink, K. and Emden, D. and Opel, N. and Redlich, R. and Repple, J. and Grotegerd, D. and Meinert, S. and Hirsch, J.G. and Niendorf, T. and Endemann, B. and Bamberg, F. and Kröncke, T. and Bülow, R. and Völzke, H. and von Stackelberg, O. and Sowade, R.F. and Umutlu, L. and Schmidt, B. and Caspers, S. and Kugel, H. and Kircher, T. and Risse, B. and Gaser, C. and Cole, J.H. and Dannlowski, U. and Berger, K.
Science Advances 8 (1): eabg9471. 7 January 2022

Rational design of highly potent, selective, and bioavailable SGK1 protein kinase inhibitors for the treatment of osteoarthritis.
Halland, N. and Schmidt, F. and Weiss, T. and Li, Z. and Czech, J. and Saas, J. and Ding-Pfennigdorff, D. and Dreyer, M.K. and Strübing, C. and Nazare, M.
Journal of Medicinal Chemistry 65 (2): 1567-1584. 27 January 2022

Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883).
Hauke, J. and Harter, P. and Ernst, C. and Burges, A. and Schmidt, S. and Reuss, A. and Borde, J. and De Gregorio, N. and Dietrich, D. and El-Balat, A. and Kayali, M. and Gevensleben, H. and Hilpert, F. and Altmüller, J. and Heimbach, A. and Meier, W. and Schoemig-Markiefka, B. and Thiele, H. and Kimmig, R. and Nürnberg, P. and Kast, K. and Richters, L. and Sehouli, J. and Schmutzler, R.K. and Hahnen, E.
Journal of Medical Genetics 59 (3): 248-252. March 2022

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Heynen, G.J.J.E. and Baumgartner, F. and Heider, M. and Patra, U. and Holz, M. and Braune, J. and Kaiser, M. and Schäffer, I. and Bamopoulos, S.A. and Ramberger, E. and Murgai, A. and Ng, Y.L.D. and Demel, U.M. and Laue, D. and Liebig, S. and Krüger, J. and Janz, M. and Nogai, A. and Schick, M. and Mertins, P. and Müller, S. and Bassermann, F. and Krönke, J. and Keller, U. and Wirth, M.
Blood Advances 2 August 2022 (In Press)

Inflammation and convergent placenta gene co-option contributed to a novel reproductive tissue.
Hilgers, L. and Roth, O. and Nolte, A.W. and Schüller, A. and Spanke, T. and Flury, J.M. and Utama, I.V. and Altmüller, J. and Wowor, D. and Misof, B. and Herder, F. and Böhne, A. and Schwarzer, J.
Current Biology 32 (3): 715-724. 7 February 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. and Kocks, C. and Leiz, J. and Karaiskos, N. and Boltengagen, A. and Cao, S. and Skopnik, C.M. and Klocke, J. and Hardenberg, J.H. and Stockmann, H. and Gotthardt, I. and Obermayer, B. and Haghverdi, L. and Wyler, E. and Landthaler, M. and Bachmann, S. and Hocke, A.C. and Corman, V. and Busch, J. and Schneider, W. and Himmerkus, N. and Bleich, M. and Eckardt, K.U. and Enghard, P. and Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Uncoupling the excitatory amino acid transporter 2 from its C-terminal interactome restores synaptic glutamate clearance at corticostriatal synapses and alleviates mutant huntingtin-induced hypokinesia.
Hirschberg, S. and Dvorzhak, A. and Rasooli-Nejad, S.M.A. and Angelov, S. and Kirchner, M. and Mertins, P. and Lättig-Tünnemann, G. and Harms, C. and Schmitz, D. and Grantyn, R.
Frontiers in Cellular Neuroscience 15 : 792652. 31 January 2022

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K. and Obermayer, B. and Hönzke, K. and Fatykhova, D. and Demir, Z. and Löwa, A. and Teixeira-Alves, L.G. and Wyler, E. and Lopez-Rodriguez, E. and Mieth, M. and Baumgardt, M. and Hoppe, J. and Firsching, T.C. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Gruber, A.D. and Ochs, M. and Landthaler, M. and Beule, D. and Suttorp, N. and Hippenstiel, S. and Hocke, A.C. and Kessler, M.
Communications Biology 5 (1): 875. 25 August 2022

Effects of separated pair housing of female C57BL/6JRj mice on well-being.
Hohlbaum, K. and Merle, R. and Frahm, S. and Rex, A. and Palme, R. and Thöne-Reineke, C. and Ullmann, K.
Scientific Reports 12 (1): 8819. 25 May 2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J. and Bartolomaeus, H. and Löber, U. and Behrens, F. and Bartolomaeus, T.U.P. and Anandakumar, H. and Wimmer, M. and Vu, D.L. and Kuhring, M. and Brüning, U. and Maifeld, A. and Geisberger, S. and Kempa, S. and Schumacher, F. and Kleuser, B. and Bufler, P. and Querfeld, U. and Kitschke, S. and Engler, D. and Kuhrt, L. and Drechsel, O. and Eckardt, K.U. and Forslund, S. and Thürmer, A. and McParland, V. and Kirwan, J. and Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology : ASN.2022030378. 19 August 2022 (In Press)

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K. and Obermayer, B. and Mache, C. and Fathykova, D. and Kessler, M. and Dökel, S. and Wyler, E. and Baumgardt, M. and Löwa, A. and Hoffmann, K. and Graff, P. and Schulze, J. and Mieth, M. and Hellwig, K. and Demir, Z. and Biere, B. and Brunotte, L. and Mecate-Zambrano, A. and Bushe, J. and Dohmen, M. and Hinze, C. and Elezkurtaj, S. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Schmidt-Ott, K.M. and Busch, J. and Klauschen, F. and Horst, D. and Radbruch, H. and Radke, J. and Heppner, F. and Corman, V.M. and Niemeyer, D. and Müller, M.A. and Goffinet, C. and Mothes, R. and Pascual-Reguant, A. and Hauser, A.E. and Beule, D. and Landthaler, M. and Ludwig, S. and Suttorp, N. and Witzenrath, M. and Gruber, A.D. and Drosten, C. and Sander, L.E. and Wolff, T. and Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 21 June 2022 (In Press)

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K. and Mensch, J. and Grimmig, M.E. and Neuner, B. and Gorzelniak, K. and Türkmen, S. and Demuth, I. and Hartmann, A. and Hartmann, C. and Wittig, F. and Sporbert, A. and Hermann, A. and Fuellen, G. and Möller, S. and Walter, M.
Science Advances 8 (33): eabk2814. August 2022

(RB1)-negative retinal organoids display proliferation of cone photoreceptors and loss of retinal differentiation.
Kanber, D. and Woestefeld, J. and Döpper, H. and Bozet, M. and Brenzel, A. and Altmüller, J. and Kilpert, F. and Lohmann, D. and Pommerenke, C. and Steenpass, L.
Cancers 14 (9): 2166. 26 April 2022

Nonproductive exposure of PBMCs to SARS‐CoV ‐2 induces cell‐intrinsic innate immune responses.
Kazmierski, J. and Friedmann, K. and Postmus, D. and Emanuel, J. and Fischer, C. and Jansen, J. and Richter, A. and Bosquillon de Jarcy, L. and Schüler, C. and Sohn, M. and Sauer, S. and Drosten, C. and Saliba, A.E. and Sander, L.E. and Müller, M.A. and Niemeyer, D. and Goffinet, C.
Molecular Systems Biology 18 (8): e10961. 1 August 2022

Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management.
Kirwan, J.A. and Gika, H. and Beger, R.D. and Bearden, D. and Dunn, W.B. and Goodacre, R. and Theodoridis, G. and Witting, M. and Yu, L.R. and Wilson, I.D.
Metabolomics 18 (9): 70. 27 August 2022

Association of ultra-rare coding variants with genetic generalized epilepsy: a case-control whole exome sequencing study.
Koko, M. and Motelow, J.E. and Stanley, K.E. and Bobbili, D.R. and Dhindsa, R.S. and May, P.
Epilepsia 63 (3): 723-735. March 2022

Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI.
Komorowski, A. and Murgaš, M. and Vidal, R. and Singh, A. and Gryglewski, G. and Kasper, S. and Wiltfang, J. and Lanzenberger, R. and Goya-Maldonado, R.
Human Brain Mapping 7 July 2022 (In Press)

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W. and Akalin, A. and Ohler, U.
Nature Machine Intelligence 4 (2): 162-168. February 2022

Paracrine interleukin 6 induces cerebral remodeling at early stages after unilateral common carotid artery occlusion in mice.
Kuffner, M.T.C. and Koch, S.P and Kirchner, M. and Mueller, S. and Lips, J. and An, J. and Mertins, P. and Dirnagl, U. and Endres, M. and Boehm-Sturm, P. and Harms, C. and Hoffmann, C.J.
Frontiers in Cardiovascular Medicine 8 : 805095. 27 January 2022

Genome engineering in rodents - status quo and perspectives.
Kühn, R.
Laboratory Animals 56 (1): 83-87. 1 February 2022

Magnetic field-induced interactions between phones containing magnets and cardiovascular implantable electronic devices: Flip it to be safe?
Lacour, P. and Dang, P.L. and Heinzel, F.R. and Parwani, A.S. and Bähr, F. and Kucher, A. and Hohendanner, F. and Niendorf, T. and Rahimi, F. and Saha, N. and Han, H. and Rubarth, K. and Sherif, M. and Boldt, L.H. and Pieske, B. and Blaschke, F.
Heart Rhythm 19 (3): 372-380. March 2022

Interleukin 8 in postoperative delirium - preliminary findings from two studies.
Lammers-Lietz, F. and Akyuz, L. and Feinkohl, I. and Lachmann, C. and Pischon, T. and Volk, H.D. and von Häfen, C. and Yürek, F. and Winterer, G. and Spies, C.D.
Brain Behavior & Immunity - Health 20 : 100419. March 2022

Alport syndrome and autosomal dominant tubulointerstitial kidney disease frequently underlie end stage renal disease of unknown origin - a single center analysis.
Leenen, E. and Erger, F. and Altmüller, J. and Wenzel, A. and Thiele, H. and Harth, A. and Tschernoster, N. and Lokhande, S. and Joerres, A. and Becker, J.U. and Ekici, A. and Huettel, B. and Beck, B. and Weidemann, A.
Nephrology Dialysis Transplantation 37 (10): 1895-1905. 22 September 2022

Spatio-temporal, optogenetic control of gene expression in organoids.
Legnini, I. and Emmenegger, L. and Zappulo, A. and Wurmus, R. and Oliveras Martinez, A. and Cerda Jara, C. and Boltengagen, A. and Hessler, T. and Mastrobuoni, G. and Rybak-Wolf, A. and Kempa, S. and Zinzen, R.P. and Woehler, A. and Rajewsky, N.
bioRxiv : 2021.09.26.461850v3. 9 February 2022

A novel homozygous synonymous variant further expands the phenotypic spectrum of POLR3A-related pathologies.
Lessel, D. and Rading, K. and Campbell, S.E. and Thiele, H. and Altmüller, J. and Gordon, L.B. and Kubisch, C.
American Journal of Medical Genetics A 188 (1): 216-223. January 2022

Phosphoinositide conversion inactivates R-RAS and drives metastases in breast cancer.
Li, H. and Prever, L. and Hsu, M.Y. and Lo, W.T. and Margaria, J.P. and De Santis, M.C. and Zanini, C. and Forni, M. and Novelli, F. and Pece, S. and Di Fiore, P.P. and Porporato, P.E. and Martini, M. and Belabed, H. and Nazare, M. and Haucke, V. and Gulluni, F. and Hirsch, E.
Advanced Science 9 (9): e2103249. 25 March 2022

High-content analysis of neuronal morphology in human iPSC-derived neurons.
Lickfett, S. and Menacho, C. and Zink, A. and Telugu, N.S. and Beller, M. and Diecke, S. and Cambridge, S. and Prigione, A.
STAR Protocols 3 (3): 101567. 16 September 2022

Diffusion-weighted magnetic resonance imaging in rat kidney using two-dimensional navigated, interleaved echo-planar imaging at 7.0 T.
Liu, Q. and Xu, Z. and Zhao, K. and Hoge, W.S. and Zhang, X. and Mei, Y. and Lu, Q. and Niendorf, T. and Feng, Y.
NMR in Biomedicine 35 (5): e4652. May 2022

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 15 September 2022 (In Press)

Tongue immune compartment analysis reveals spatial macrophage heterogeneity.
Lyras, E.M. and Zimmermann, K. and Wagner, L.K. and Dörr, D. and Klose, C.S.N and Fischer, C. and Jung, S. and Yona, S. and Hovav, A.H. and Stenzel, W. and Dommerich, S. and Conrad, T. and Leutz, A. and Mildner, A.
eLife 11 : 77490. 24 June 2022

Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
Mackert, O. and Wirth, E.K. and Sun, R. and Winkler, J. and Liu, A. and Renko, K. and Kunz, S. and Spranger, J. and Brachs, S.
Molecular Metabolism 64 : 101563. October 2022

Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development.
Marko, H.L. and Hornig, N.C. and Betz, R.C. and Holterhus, P.M. and Altmüller, J. and Thiele, H. and Fabiano, M. and Schweikert, H.U. and Braun, D. and Schweizer, U.
Human Mutation 43 (3): 420-433. March 2022

ClearCNV: CNV calling from NGS panel data in the presence of ambiguity and noise.
May, V. and Koch, L. and Fischer-Zirnsak, B. and Horn, D. and Gehle, P. and Kornak, U. and Beule, D. and Holtgrewe, M.
Bioinformatics 25 June 2022 (In Press)

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Mattonet, K. and Kempfer, R. and Hirsekorn, A. and Bilić, I. and Gil, M. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
Cell Genomics 2 (1): 100083. 13 January 2022

Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets.
Melder, F.T. and Lindemann, P. and Welle, A. and Trouillet, V. and Heißler, S. and Nazaré, M. and Selbach, M.
ChemMedChem 22 July 2022 (In Press)

Generation of hiPSC-derived skeletal muscle cells: exploiting the potential of skeletal muscle-derived hiPSCs.
Metzler, E. and Escobar, H. and Sunaga-Franze, D.Y. and Sauer, S. and Diecke, S. and Spuler, S.
Biomedicines 10 (5): 1204. 23 May 2022

Genomic basis of syndromic short stature in an Algerian patient cohort.
Moosa, S. and Chentli, F. and Altmüller, J. and Bögershausen, N. and Nürnberg, P. and Yigit, G. and Li, Y. and Wollnik, B.
American Journal of Medical Genetics A 188 (2): 606-612. February 2022

Political knowledge and misinformation in the era of social media: evidence from the 2015 UK election.
Munger, K. and Egan, P.J. and Nagler, J. and Ronen, J. and Tucker, J.
British Journal of Political Science 52 (1): 107 - 127. January 2022

Increased salt intake decreases diet-induced thermogenesis in healthy volunteers: a randomized placebo-controlled study.
Mähler, A. and Klamer, S. and Maifeld, A. and Bartolomaeus, H. and Markó, L. and Chen, C.Y. and Forslund, S.K. and Boschmann, M. and Müller, D.N. and Wilck, N.
Nutrients 14 (2): 253. 7 January 2022

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D. and Ramberger, E. and Bohl, S.R. and Dolnik, A. and Steinebach, C. and Conrad, T. and Müller, S. and Popp, O. and Kull, M. and Haji, M. and Gütschow, M. and Döhner, H. and Walther, W. and Keller, U. and Bullinger, L. and Mertins, P. and Krönke, J.
Nature Communications 13 (1): 1009. 23 February 2022

Generation of a NES-mScarlet red fluorescent reporter human iPSC line for live cell imaging and flow cytometric analysis and sorting using CRISPR-Cas9-mediated gene editing.
Nouri, P. and Zimmer, A. and Brüggemann, S. and Friedrich, R. and Kühn, R. and Prakash, N.
Cells 11 (2): 268. 13 January 2022

Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens.
Numberger, D. and Zoccarato, L. and Woodhouse, J. and Ganzert, L. and Sauer, S. and García Márquez, J.R. and Domisch, S. and Grossart, H.P. and Greenwood, A.D.
Science of the Total Environment 845 : 157321. 1 November 2022

Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
Offer, S. and Hartner, E. and Di Bucchianico, S. and Bisig, C. and Bauer, S. and Pantzke, J. and Zimmermann, E.J. and Cao, X. and Binder, S. and Kuhn, E. and Huber, A. and Jeong, S. and Käfer, U. and Martens, P. and Mesceriakovas, A. and Bendl, J. and Brejcha, R. and Buchholz, A. and Gat, D. and Hohaus, T. and Rastak, N. and Jakobi, G. and Kalberer, M. and Kanashova, T. and Hu, Y. and Ogris, C. and Marsico, A. and Theis, F. and Pardo, M. and Gröger, T. and Oeder, S. and Orasche, J. and Paul, A. and Ziehm, T. and Zhang, Z.H. and Adam, T. and Sippula, O. and Sklorz, M. and Schnelle-Kreis, J. and Czech, H. and Kiendler-Scharr, A. and Rudich, Y. and Zimmermann, R.
Environmental Health Perspectives 130 (2): 27003. 3 February 2022

A computational model for prediction of ferritin and haemoglobin levels in blood donors.
Paalvast, Y. and Moazzen, S. and Sweegers, M. and Hogema, B. and Janssen, M. and van den Hurk, K.
British Journal of Haematology 199 (1): 143-152. October 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
Pardo, M. and Offer, S. and Hartner, E. and Di Bucchianico, S. and Bisig, C. and Bauer, S. and Pantzke, J. and Zimmermann, E.J. and Cao, X. and Binder, S. and Kuhn, E. and Huber, A. and Jeong, S. and Käfer, U. and Schneider, E. and Mesceriakovas, A. and Bendl, J. and Brejcha, R. and Buchholz, A. and Gat, D. and Hohaus, T. and Rastak, N. and Karg, E. and Jakobi, G. and Kalberer, M. and Kanashova, T. and Hu, Y. and Ogris, C. and Marsico, A. and Theis, F. and Shalit, T. and Gröger, T. and Rüger, C.P. and Oeder, S. and Orasche, J. and Paul, A. and Ziehm, T. and Zhang, Z.H. and Adam, T. and Sippula, O. and Sklorz, M. and Schnelle-Kreis, J. and Czech, H. and Kiendler-Scharr, A. and Zimmermann, R. and Rudich, Y.
Environment International 166 : 107366. 21 June 2022 (In Press)

A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.
Patsalos, A. and Halasz, L. and Medina-Serpas, M.A. and Berger, W.K. and Daniel, B. and Tzerpos, P. and Kiss, M. and Nagy, G. and Fischer, C. and Simandi, Z. and Varga, T. and Nagy, L.
Journal of Experimental Medicine 219 (1): e20210420. 3 January 2022

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K. and Leunig, A. and Kaiser, R. and Joppich, M. and Brambs, S. and Janjic, A. and Popp, O. and Nixdorf, D. and Fumagalli, V. and Schmidt, N. and Polewka, V. and Anjum, A. and Knottenberg, V. and Eivers, L. and Wange, L.E. and Gold, C. and Kirchner, M. and Muenchhoff, M. and Hellmuth, J.C. and Scherer, C. and Rubio-Acero, R. and Eser, T. and Deák, F. and Puchinger, K. and Kuhl, N. and Linder, A. and Saar, K. and Tomas, L. and Schulz, C. and Wieser, A. and Enard, W. and Kroidl, I. and Geldmacher, C. and von Bergwelt-Baildon, M. and Keppler, O.T. and Munschauer, M. and Iannacone, M. and Zimmer, R. and Mertins, P. and Hubner, N. and Hoelscher, M. and Massberg, S. and Stark, K. and Nicolai, L.
Nature Communications 13 (1): 1018. 23 February 2022

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz, P. and Kirsten, H. and Friedrich, V.D. and Wyler, E. and Goekeri, C. and Obermayer, B. and Heinz, G.A. and Mashreghi, M.F. and Büttner, M. and Trimpert, J. and Landthaler, M. and Suttorp, N. and Hocke, A.C. and Hippenstiel, S. and Tönnies, M. and Scholz, M. and Kuebler, W.M. and Witzenrath, M. and Hoenzke, K. and Nouailles, G.
European Respiratory Review 31 (165): 220056. 30 September 2022

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I. and Seeger, T. and Bruyneel, A.A.N. and Termglinchan, V. and Monte, E. and Lim, E.W. and Vadgama, N. and Furihata, T. and Gavidia, A.A. and Arthur Ataam, J. and Bharucha, N. and Martinez-Amador, N. and Ameen, M. and Nair, P. and Serrano, R. and Kaur, B. and Feyen, D.A.M. and Diecke, S. and Snyder, M.P. and Metallo, C.M. and Mercola, M. and Karakikes, I.
European Heart Journal 43 (36): 3477-3489. 21 September 2022

A RAS-independent biomarker panel to reliably predict response to MEK inhibition in colorectal cancer.
Pfohl, U. and Loskutov, J. and Bashir, S. and Kühn, R. and Herter, P. and Templin, M. and Mamlouk, S. and Belanov, S. and Linnebacher, M. and Bürtin, F. and Vetter, M. and Reinhard, C. and Wedeken, L. and Regenbrecht, C.R.A.
Cancers 14 (13): 3252. 1 July 2022

RNA modification mapping with JACUSA2.
Piechotta, M. and Naarmann-de Vries, I.S. and Wang, Qi and Altmüller, J. and Dieterich, C.
Genome Biology 23 (1): 115. 16 May 2022

Sustainable low-field cardiovascular magnetic resonance in changing healthcare systems.
Qin, C. and Murali, S. and Lee, E. and Supramaniam, V. and Hausenloy, D.J. and Obungoloch, J. and Brecher, J. and Lin, R. and Ding, H. and Akudjedu, T.N. and Anazodo, U.C. and Jagannathan, N.R. and Ntusi, N.A.B. and Simonetti, O.P. and Campbell-Washburn, A.E. and Niendorf, T. and Mammen, R. and Adeleke, S.
European Heart Journal - Cardiovascular Imaging : jeab286. 14 February 2022

Radiofrequency antenna helmet array for thermal magnetic resonance of brain tumours at 297 MHz.
Rahimi, F. and Berangi, M. and Eigentler, T.W. and Nurzed, B. and Millward, J.M. and Schuhmann, R. and Niendorf, T.
In: 2022 3rd URSI Atlantic and Asia Pacific Radio Science Meeting (AT-AP-RASC), 30 May - 04 Jun 2022, Gran Canaria, Spain. 6 July 2022

EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A. and Wirges, A. and Hoser, D. and Fischer, C. and Herda, S. and Gerlach, K. and Sauer, S. and Willimsky, G. and Hoepken, U.E.
JCI Insight 7 (11): e155534. 8 June 2022

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D. and Lindberg, E.L. and Maatz, H. and Miranda, A.M.A. and Viveiros, A. and Shvetsov, N. and Gärtner, A. and Nadelmann, E.R. and Lee, M. and Kanemaru, K. and Ruiz-Orera, J. and Strohmenger, V. and DeLaughter, D.M. and Patone, G. and Zhang, H. and Woehler, A. and Lippert, C. and Kim, Y. and Adami, E. and Gorham, J.M. and Barnett, S.N. and Brown, K. and Buchan, R.J. and Chowdhury, R.A. and Constantinou, C. and Cranley, J. and Felkin, L.E. and Fox, H. and Ghauri, A. and Gummert, J. and Kanda, M. and Li, R. and Mach, L. and McDonough, B. and Samari, S. and Shahriaran, F. and Yapp, C. and Stanasiuk, C. and Theotokis, P.I. and Theis, F.J. and van den Bogaerdt, A. and Wakimoto, H. and Ware, J.S. and Worth, C.L. and Barton, P.J.R. and Lee, Y.A. and Teichmann, S.A. and Milting, H. and Noseda, M. and Oudit, G.Y. and Heinig, M. and Seidman, J.G. and Hubner, N. and Seidman, C.E.
Science 377 (6606): eabo1984. 5 August 2022

MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells.
Reusch, B. and Bartram, M.P. and Dafinger, C. and Palacio-Escat, N. and Wenzel, A. and Fenton, R.A. and Saez-Rodriguez, J. and Schermer, B. and Benzing, T. and Altmüller, J. and Beck, B.B. and Rinschen, M.M.
Journal of Proteomics 252 : 104424. 10 February 2022

Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.
Reuter, M.S. and Zech, M. and Hempel, M. and Altmüller, J. and Heung, T. and Pölsler, L. and Santer, R. and Thiele, H. and Trost, B. and Kubisch, C. and Scherer, S.W. and Rudnik-Schöneborn, S. and Bassett, A.S. and Lessel, D.
European Journal of Human Genetics 30 (5): 611–618. May 2022

Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship: a randomized, cross-over pilot study.
Riveros-Rivera, A. and Penzel, T. and Gunga, H.C. and Opatz, O. and Paul, F. and Klug, L. and Boschmann, M. and Mähler, A.
Frontiers in Physiology 13 : 899636. 24 May 2022

Prevalence of cancer predisposition germline variants in male breast cancer patients: results of the German Consortium for Hereditary Breast and Ovarian Cancer.
Rolfes, M. and Borde, J. and Möllenhoff, K. and Kayali, M. and Ernst, C. and Gehrig, A. and Sutter, C. and Ramser, J. and Niederacher, D. and Horváth, J. and Arnold, N. and Meindl, A. and Auber, B. and Rump, A. and Wang-Gohrke, S. and Ritter, J. and Hentschel, J. and Thiele, H. and Altmüller, J. and Nürnberg, P. and Rhiem, K. and Engel, C. and Wappenschmidt, B. and Schmutzler, R.K. and Hahnen, E. and Hauke, J.
Cancers 14 (13): 3292. 5 July 2022

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M. and von Arx, A.S. and Cruz-Ochoa, N. and Dawson, K. and Ivanov, A. and Mueller, F.S. and Lin, H.Y. and Amport, R. and Mildenberger, W. and Mattei, D. and Beule, D. and Földy, C. and Greter, M. and Notter, T. and Meyer, U.
Science Advances 8 (9): eabi6672. 4 March 2022

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.
Schepanski, S. and Chini, M. and Sternemann, V. and Urbschat, C. and Thiele, K. and Sun, T. and Zhao, Y. and Poburski, M. and Woestemeier, A. and Thieme, M.T. and Zazara, D.E. and Alawi, M. and Fischer, N. and Heeren, J. and Vladimirov, N. and Woehler, A. and Puelles, V.G. and Bonn, S. and Gagliani, N. and Hanganu-Opatz, I.L. and Arck, P.C.
Nature Communications 13 (1): 4571. 5 August 2022

Familial cleft tongue caused by a unique translation initiation codon variant in TP63.
Schmidt, J. and Schreiber, G. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Li, Y. and Kaulfuß, S. and Funke, R. and Wilken, B. and Yigit, G. and Wollnik, B.
European Journal of Human Genetics 30 (2): 211-218. February 2022

Whole-body magnetic resonance imaging in the large population-based German National Cohort study: predictive capability of automated image quality assessment for protocol repetitions.
Schuppert, C. and von Krüchten, R. and Hirsch, J.G. and Rospleszcz, S. and Hoinkiss, D.C. and Selder, S. and Köhn, A. and von Stackelberg, O. and Peters, A. and Völzke, H. and Kröncke, T. and Niendorf, T. and Forsting, M. and Hosten, N. and Hendel, T. and Pischon, T. and Jöckel, K.H. and Kaaks, R. and Bamberg, F. and Kauczor, H.U. and Günther, M. and Schlett, C.L.
Investigative Radiology 57 (7): 478-487. 1 July 2022

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Schwab, K. and Chasapopoulou, Z. and Frahm, S. and Magbagbeolu, M. and Cranston, A. and Harrington, C.R. and Wischik, C.M. and Theuring, F. and Riedel, G.
Cellular Signalling 97 : 110386. September 2022

Eating patterns during pregnancy and postpartum and their association with diet quality and energy intake.
Schwedhelm, C. and Lipsky, L.M. and Temmen, C.D. and Nansel, T.R.
Nutrients 14 (6): 1167. 10 March 2022

3D-printed tissue-simulating phantoms for near-infrared fluorescence imaging of rheumatoid diseases.
Schädel-Ebner, S. and Hirsch, O. and Gladytz, T. and Gutkelch, D. and Licha, K. and Berger, J. and Grosenick, D.
Journal of Biomedical Optics 27 (7): 074702. July 2022

Pathogenic variants in cardiomyopathy disorder genes underlie pediatric myocarditis - Further impact of heterozygous immune disorder gene variants?
Seidel, F. and Laser, K.T. and Klingel, K. and Dartsch, J. and Theisen, S. and Pickardt, T. and Holtgrewe, M. and Gärtner, A. and Berger, F. and Beule, D. and Milting, H. and Schubert, S. and Klaassen, S. and Kühnisch, J.
Journal of Cardiovascular Development and Disease 9 (7): 216. 5 July 2022

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.
Smajić, S. and Prada-Medina, C.A. and Landoulsi, Z. and Ghelfi, J. and Delcambre, S. and Dietrich, C. and Jarazo, J. and Henck, J. and Balachandran, S. and Pachchek, S. and Morris, C.M. and Antony, P. and Timmermann, B. and Sauer, S. and Pereira, S.L. and Schwamborn, J.C. and May, P. and Grünewald, A. and Spielmann, M.
Brain 145 (3): 964-978. March 2022

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors.
Specker, E. and Matthes, S. and Wesolowski, R. and Schütz, A. and Grohmann, M. and Alenina, N. and Pleimes, D. and Mallow, K. and Neuenschwander, M. and Gogolin, A. and Weise, M. and Pfeifer, J. and Ziebart, N. and Heinemann, U. and von Kries, J.P. and Nazaré, M. and Bader, M.
Journal of Medicinal Chemistry 65 (16): 11126-11149. 25 August 2022

Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies.
Thomalla, D. and Beckmann, L. and Grimm, C. and Oliverio, M. and Meder, L. and Herling, C.D. and Nieper, P. and Feldmann, T. and Merkel, O. and Lorsy, E. and da Palma Guerreiro, A. and von Jan, J. and Kisis, I. and Wasserburger, E. and Claasen, J. and Faitschuk-Meyer, E. and Altmüller, J. and Nürnberg, P. and Yang, T.P. and Lienhard, M. and Herwig, R. and Kreuzer, K.A. and Pallasch, C.P. and Buettner, R. and Schäfer, S.C. and Hartley, J. and Abken, H. and Peifer, M. and Kashkar, H. and Knittel, G. and Eichhorst, B. and Ullrich, R.T. and Herling, M. and Reinhardt, H.C. and Hallek, M. and Schweiger, M.R. and Frenzel, L.P.
Blood 15 June 2022 (In Press)

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. and Danner, E. and Li, X. and Graf, R. and Lebedin, M. and de la Rosa, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022

Unraveling structural rearrangements of the CFH gene cluster in atypical hemolytic uremic syndrome patients using molecular combing and long-fragment targeted sequencing.
Tschernoster, N. and Erger, F. and Walsh, P.R. and McNicholas, B. and Fistrek, M. and Habbig, S. and Schumacher, L. and Folz-Donahue, K. and Kukat, C. and Toliat, M.R. and Becker, C. and Thiele, H. and Kavanagh, D. and Nürnberg, P. and Beck, B. and Altmüller, J.
Journal of Molecular Diagnostics 24 (6): 619-631. June 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H. and Dauksaite, V. and Sporbert, A. and Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083.e8. 2 June 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R. and Pallien, T. and Miller, D.C. and Oder, A. and Neuenschwander, M. and von Kries, J.P. and Diecke, S. and Klussmann, E.
Methods in Molecular Biology 2483 : 117-139. 2022

Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay.
Wallmeroth, D. and Lackmann, J.W. and Kueckelmann, S. and Altmüller, J. and Dieterich, C. and Boehm, V. and Gehring, N.H.
EMBO Journal 41 (10): e109191. 16 May 2022

Venn diagrams may indicate erroneous statistical reasoning in transcriptomics.
Weiner, J. and Obermayer, B. and Beule, D.
Frontiers in Genetics 13 : 818683. 14 April 2022

Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C. and Lammoglia Cobo, M.F. and Stein, C.A. and Hsu, M.T. and Ben Hamza, A. and Penter, L. and Chen, X. and Buccitelli, C. and Popp, O. and Mertins, P. and Dietze, K. and Bullinger, L. and Moosmann, A. and Blanc, E. and Beule, D. and Gerbitz, A. and Strobel, J. and Hackstein, H. and Rahn, H.P. and Dornmair, K. and Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 19 September 2022 (In Press)

Can fractal dimensions objectivize gastropod shell morphometrics? A case study from Lake Lugu (SW China).
Wiese, R. and Harrington, K. and Hartmann, K. and Hethke, M. and Rintelen, T. and Zhang, H. and Zhang, L.J. and Riedel, F.
Ecology and Evolution 12 (3): e8622. February 2022

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A. and Bunse, M. and Joedicke, J.J. and Blanc, E. and Gudipati, V. and Moles, M.W. and Shiku, H. and Beule, D. and Huppa, J.B. and Höpken, U.E. and Rehm, A.
Molecular Therapy 12 July 2022 (In Press)

Mutations in TAF8 cause a neurodegenerative disorder.
Wong, K.M. and Jepsen, W.M. and Efthymiou, S. and Salpietro, V. and Sanchez-Castillo, M. and Yip, J. and Kriouile, Y. and Diegmann, S. and Dreha-Kulaczewski, S. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Toosi, M.B. and Akhondian, J. and Ghayoor Karimiani, E. and Hummel-Abmeier, H. and Huppke, B. and Houlden, H. and Gärtner, J. and Maroofian, R. and Huppke, P.
Brain 145 (9): 3022-3034. September 2022

The transcription factor EB (TFEB) sensitizes the heart to chronic pressure overload.
Wundersitz, S. and Pablo Tortola, C. and Schmidt, S. and Oliveira Vidal, R. and Kny, M. and Hahn, A. and Zanders, L. and Katus, H.A. and Sauer, S. and Butter, C. and Luft, F.C. and Müller, O.J. and Fielitz, J.
International Journal of Molecular Sciences 23 (11): 5943. 25 May 2022

Loss-of-function variants in DNM1 cause a specific form of developmental and epileptic encephalopathy only in biallelic state.
Yigit, G. and Sheffer, R. and Daana, M. and Li, Y. and Kaygusuz, E. and Mor-Shakad, H. and Altmüller, J. and Nürnberg, P. and Douiev, L. and Kaulfuss, S. and Burfeind, P. and Wollnik, B. and Brockmann, K.
Journal of Medical Genetics 59 (6): 549-553. 20 May 2022

A preclinical study on brugada syndrome with a CACNB2 variant using human cardiomyocytes from induced pluripotent stem cells.
Zhong, R. and Schimanski, T. and Zhang, F. and Lan, H. and Hohn, A. and Xu, Q. and Huang, M. and Liao, Z. and Qiao, L. and Yang, Z. and Li, Y. and Zhao, Z. and Li, X. and Rose, L. and Albers, S. and Maywald, L. and Müller, J. and Dinkel, H. and Saguner, A. and Janssen, J.W.G. and Telugu, N.S. and Xi, Y. and Lang, S. and Kleinsorge, M. and Duru, F. and Zhou, X. and Diecke, S. and Cyganek, L. and Akin, I. and El-Battrawy, I.
International Journal of Molecular Sciences 23 (15): 8313. 1 August 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U. and Milek, M. and Minia, I. and Vieira-Vieira, C.H. and Müller, S. and Mastrobuoni, G. and Hazapis, O.G. and Del Giudice, S. and Schwefel, D. and Bley, N. and Voigt, F. and Chao, J.A. and Kempa, S. and Hüttelmaier, S. and Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.
Zou, X. and Schaefke, B. and Li, Y. and Jia, F. and Sun, W. and Li, G. and Liang, W. and Reif, T. and Heyd, F. and Gao, Q. and Tian, S. and Li, Y. and Tang, Y. and Fang, L. and Hu, Y. and Chen, W.
Life Science Alliance 5 (4): e202101333. April 2022

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V. and Rusha, E. and Shaposhnikov, D. and Ruiz-Orera, J. and Telugu, N. and Rishko, V. and Hayashi, M. and Michel, G. and Wittler, L. and Stejskal, J. and Holtze, S. and Göritz, F. and Hermes, R. and Wang, J. and Izsvák, Z. and Colleoni, S. and Lazzari, G. and Galli, C. and Hildebrandt, T.B. and Hayashi, K. and Diecke, S. and Drukker, M.
Scientific Reports 12 (1): 3100. 8 March 2022

Therapeutic targets for phenolic compounds from agro-industrial by-products against obesity.
de la Luz Cádiz-Gurrea, M. and Fernández-Ochoa, Á. and Del Carmen Villegas-Aguilar, M. and Arráez-Román, D. and Segura-Carretero, A.
Current Medicinal Chemistry 29 (6): 1083-1098. 2022

2021

Mapping the human genetic architecture of COVID-19.

Nature 600 (7889): 472-477. December 2021

Preclinical MRI of the kidney : methods and protocols.
Pohlmann, A. and Niendorf, T., eds.
Methods in Molecular Biology, 2216 . Springer / Humana Press, New York, NY. ISBN 978-1-0716-0977-4 2021

Feasibility of a culturally adapted dietary weight-loss intervention among Ghanaian migrants in Berlin, Germany: the ADAPT study.
Amoah, S. and Ennin, R. and Sagoe, K. and Steinbrecher, A. and Pischon, T. and Mockenhaupt, F.P. and Danquah, I.
International Journal of Environmental Research and Public Health 18 (2): 510. 9 January 2021

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. and Acemel, R.D. and Jedamzick, J. and Bolondi, A. and Cova, G. and Brieske, N. and Kuehn, R. and Wittler, L. and Real, F.M. and Lupianez, D.G.
bioRxiv : 2021.04.14.439779. 14 April 2021

Putative mobilized colistin resistance genes in the human gut microbiome.
Andrade, B.G.N. and Goris, T. and Afli, H. and Coutinho, F.H. and Dávila, A.M.R. and Cuadrat, R.R.C.
BMC Microbiology 21 : 220. 22 July 2021

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M. and Franke, V. and Bruno, M. and Grishkovskaya, I. and Kasiliauskaite, A. and Kaufmann, T. and Schoeberl, U.E. and Puchinger, M.G. and Kostrhon, S. and Ebenwaldner, C. and Sebesta, M. and Beltzung, E. and Mechtler, K. and Lin, G. and Vlasova, A. and Leeb, M. and Pavri, R. and Stark, A. and Akalin, A. and Stefl, R. and Bernecky, C. and Djinovic-Carugo, K. and Slade, D.
Nature Communications 12 (1): 6078. 19 October 2021

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt, B. and Mastrobuoni, G. and Wuenschel, J. and Astrahantseff, K. and Eggert, A. and Kempa, S. and Deubzer, H.E.
Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1): 1282-1289. 30 June 2021

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, B. and Zasada, C. and Baum, K. and Wuenschel, J. and Mastrobuoni, G. and Lodrini, M. and Astrahantseff, K. and Winkler, A. and Schulte, J.H. and Finkler, S. and Forbes, M. and Hundsdoerfer, P. and Guergen, D. and Hoffmann, J. and Wolf, J. and Eggert, A. and Kempa, S. and Deubzer, H.E.
International Journal of Cancer 148 (5): 1219-1232. 1 March 2021

SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C. and Günther, U. and Eddison, M. and Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18 : 374-377. April 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study.
Augustin, M. and Schommers, P. and Stecher, M. and Dewald, F. and Gieselmann, L. and Gruell, H. and Horn, C. and Vanshylla, K. and Cristanziano, V.D. and Osebold, L. and Roventa, M. and Riaz, T. and Tschernoster, N. and Altmueller, J. and Rose, L. and Salomon, S. and Priesner, V. and Luers, J.C. and Albus, C. and Rosenkranz, S. and Gathof, B. and Fätkenheuer, G. and Hallek, M. and Klein, F. and Suárez, I. and Lehmann, C.
The Lancet Regional Health - Europe 6 : 100122. July 2021

Assessing the (anti)-inflammatory potential of diets.
Bahr, L.S. and Franz, K. and Mähler, A.
Current Opinion in Clinical Nutrition and Metabolic Care 24 (5): 402-410. 1 September 2021

RS-FISH: Precise, interactive, fast, and scalable FISH spot detection.
Bahry, E. and Breimann, L. and Zouinkhi, M. and Epstein, L. and Kolyvanov, K. and Long, X. and Harrington, K.I.S. and Lionnet, T. and Preibisch, S.
bioRxiv : 2021.03.09.434205v2. 18 October 2021

Ultra-rapid emergency genomic diagnosis of Donahue syndrome in a preterm infant within 17 hours.
Bamborschke, D. and Özdemir, Ö. and Kreutzer, M. and Motameny, S. and Thiele, H. and Kribs, A. and Dötsch, J. and Altmüller, J. and Nürnberg, P. and Cirak, S.
American Journal of Medical Genetics A 185 (1): 90-96. January 2021

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics.
Baytek, G. and Blume, A. and Gerceker Demirel, F. and Bulut, S. and Mertins, P. and Tursun, B.
bioRxiv : 2021.02.14.431134. 14 February 2021

CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N. and Eckstein, J. and Wallach, I. and Nordmeyer, S. and Kelm, M. and Kirchner, M. and Goubergrits, L. and Schafstedde, M. and Hennemuth, A. and Kraus, M. and Grune, T. and Mertins, P. and Kuehne, T. and Holzhütter, H.G.
Circulation 144 (24): 1926-1939. 14 December 2021

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma.
Bischoff, P. and Trinks, A. and Obermayer, B. and Pett, J.P. and Wiederspahn, J. and Uhlitz, F. and Liang, X. and Lehmann, A. and Jurmeister, P. and Elsner, A. and Dziodzio, T. and Rückert, J.C. and Neudecker, J. and Falk, C. and Beule, D. and Sers, C. and Morkel, M. and Horst, D. and Blüthgen, N. and Klauschen, F.
Oncogene 40 : 6748–6758. 16 December 2021

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Boehm, V. and Kueckelmann, S. and Gerbracht, J.V. and Kallabis, S. and Britto-Borges, T. and Altmüller, J. and Krüger, M. and Dieterich, C. and Gehring, N.H.
Nature Communications 12 (1): 3965. 25 June 2021

A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover.
Boileau, E. and Altmüller, J. and Naarmann-de Vries, I.S. and Dieterich, C.
Briefings in Bioinformatics 22 (6): bbab219. November 2021

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
Bonnekoh, H. and Vera, C. and Abad-Perez, A. and Radetzki, S. and Neuenschwander, M. and Specker, E. and Mahnke, N.A. and Frischbutter, S. and Latz, E. and Nazaré, M. and von Kries, J. and Maurer, M. and Scheffel, J. and Krause, K.
Clinical and Translational Allergy 11 (5): e12045. July 2021

The H4K20 demethylase DPY-21 regulates the dynamics of condensin DC binding.
Breimann, L. and Morao, A.K. and Kim, J. and Jimenez, D. and Maryn, N. and Bikkasani, K. and Carrozza, M.J. and Albritton, S.E. and Kramer, M. and Street, L.A. and Cerimi, K. and Schumann, V.F. and Bahry, E. and Preibisch, S. and Woehler, A. and Ercan, S.
bioRxiv : 2021.04.11.438056. 24 September 2021

Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010.
Brennecke, B. and Gazzi, T. and Atz, K. and Fingerle, J. and Kuner, P. and Schindler, T. and de Weck, G. and Nazaré, M. and Grether, U.
Pharmaceutical Patent Analyst 10 (3): 111-163. May 2021

DOTAM-based, targeted, activatable fluorescent probes for the highly sensitive and selective detection of cancer cells.
Brennecke, B. and Wang, Q. and Haap, W. and Grether, U. and Hu, H.Y. and Nazaré, M.
Bioconjugate Chemistry 32 (4): 702-712. 21 April 2021

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila.
Brown, J.B. and Langley, S.A. and Snijders, A.M. and Wan, K.H. and Morris, S.N.S. and Booth, B.W. and Fisher, W.W. and Hammonds, A.S. and Park, S. and Weiszmann, R. and Yu, C. and Kirwan, J.A. and Weber, R.J.M. and Viant, M.R. and Mao, J.H. and Celniker, S.E.
Communications Biology 4 (1): 1324. 24 November 2021

Radiation driven chemistry in biomolecules -- is (V)UV involved in the bioactivity of argon jet plasmas?
Bruno, G. and Wenske, S. and Mahdikia, H. and Gerling, T. and von Woedtke, T. and Wende, K.
Frontiers in Physics 9 : 759005. 14 December 2021

Coregulation of gene expression by White collar 1 and phytochrome in Ustilago maydis.
Brych, A. and Haas, F.B. and Parzefall, K. and Panzer, S. and Schermuly, J. and Altmüller, J. and Engelsdorf, T. and Terpitz, U. and Rensing, S.A. and Kiontke, S. and Batschauer, A.
Fungal Genetics and Biology 152 : 103570. July 2021

Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage.
Bubb, K. and Holzer, T. and Nolte, J.L. and Krüger, M. and Wilson, R. and Schlötzer-Schrehardt, U. and Brinckmann, J. and Altmüller, J. and Aszodi, A. and Fleischhauer, L. and Clausen-Schaumann, H. and Probst, K. and Brachvogel, B.
Journal of Biological Chemistry 297 (4): 101224. October 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K. and Kny, M. and Huang, N. and Klassert, T.E. and Stock, M. and Hahn, A. and Graeger, S. and Todiras, M. and Schmidt, S. and Chamling, B. and Willenbrock, M. and Groß, S. and Biedenweg, D. and Heuser, A. and Scheidereit, C. and Butter, C. and Felix, S.B. and Otto, O. and Luft, F.C. and Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts.
Cantow, K. and Evans, R.G. and Grosenick, D. and Gladytz, T. and Niendorf, T. and Flemming, B. and Seeliger, E.
Methods in Molecular Biology 2216 : 89-107. 2021

Monitoring renal hemodynamics and oxygenation by invasive probes: experimental protocol.
Cantow, K. and Ladwig-Wiegard, M. and Flemming, B. and Pohlmann, A. and Niendorf, T. and Seeliger, E.
Methods in Molecular Biology 2216 : 327-347. 2021

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer.
Carter, D.M. and Specker, E. and Malecki, P.H. and Przygodda, J. and Dudaniec, K. and Weiss, M.S. and Heinemann, U. and Nazaré, M. and Gohlke, U.
Journal of Medicinal Chemistry 64 (19): 14266-14282. 14 October 2021

Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS).
Cernoch, J. and Fisch, T. and Fischer, I. and Fischer, K. and Iwanska, A. and Krüger, N. and Küchler, J. and Schaar, C. and Schommer, S. and Telugu, N. and Miller, D. and Fernández Vallone, V. and Kurtz, A. and Reinke, P. and Diecke, S. and Stachelscheid, H.
Stem Cell Research 54 : 102406. July 2021

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Chatzidoukaki, O. and Stratigi, K. and Goulielmaki, E. and Niotis, G. and Akalestou-Clocher, A. and Gkirtzimanaki, K. and Zafeiropoulos, A. and Altmüller, J. and Topalis, P. and Garinis, G.A.
Science Advances 7 (47): eabj5769. 19 November 2021

Quantitative analysis of renal perfusion by arterial spin labeling.
Chuang, K.H. and Kober, F. and Ku, M.C.
Methods in Molecular Biology 2216 : 655-666. 2021

Renal blood flow using arterial spin labeling (ASL) MRI: experimental protocol and principles.
Chuang, K.H. and Meier, M. and Fernández-Seara, M.A. and Kober, F. and Ku, M.C.
Methods in Molecular Biology 2216 : 443-453. 2021

Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann, M. and Gambara, G. and Brzezicha, B. and Popp, O. and Pachmayr, E. and Wedeken, L. and Pflaume, A. and Mokritzkij, M. and Gül-Klein, S. and Brandl, A. and Schweiger-Eisbacher, C. and Mertins, P. and Hoffmann, J. and Keilholz, U. and Walther, W. and Regenbrecht, C. and Rau, B. and Stein, U.
Molecular Cancer 20 (1): 129. 21 October 2021

Cores laboratories: organization for stem cell technology advancement.
Dahéron, L. and Diecke, S. and Healy, L. and D'Souza, S.
Stem Cell Research 53 : 102266. May 2021

Clinical and genetic characterization of PYROXD1-related myopathy patients from Turkey.
Daimagüler, H.S. and Akpulat, U. and Özdemir, Ö. and Yis, U. and Güngör, S. and Talim, B. and Diniz, G. and Baydan, F. and Thiele, H. and Altmüller, J. and Nürnberg, P. and Cirak, S.
American Journal of Medical Genetics A 185 (6): 1678-1690. 14 May 2021

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. and Lebedin, M. and de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021

Hardware considerations for preclinical magnetic resonance of the kidney.
Delgado, P.R. and Küstermann, E. and Kühne, A. and Millward, J.M. and Niendorf, T. and Pohlmann, A. and Meier, M.
Methods in Molecular Biology 2216 : 131-155. 2021

Current applications and future development of magnetic resonance fingerprinting in diagnosis, characterization, and response monitoring in cancer.
Ding, H. and Velasco, C. and Ye, H. and Lindner, T. and Grech-Sollars, M. and O’Callaghan, J. and Hiley, C. and Chouhan, M.D. and Niendorf, T. and Koh, D.M. and Prieto, C. and Adeleke, S.
Cancers 13 (19): 4742. 1 October 2021

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M. and Klinger, B. and Mari, T. and Toedling, J. and Blanc, E. and Messerschmidt, C. and Nadler-Holly, M. and Ziehm, M. and Sieber, A. and Hertwig, F. and Beule, D. and Eggert, A. and Schulte, J.H. and Selbach, M. and Blüthgen, N.
PLoS Computational Biology 17 (11): e1009515. 4 November 2021

Mechanical forces switch blood vessel subtypes to arrest adolescent bone growth.
Dzamukova, M. and Brunner, T.M. and Miotla-Zarebska, J. and Heinrich, F. and Brylka, L. and Mashreghi, M.F. and Kusumbe, A. and Kühn, R. and Schinke, T. and Vincent, T. and Löhning, M.
Research Square : rs.3.rs-120475. 12 January 2021

Long-term follow-up after the application of mesenchymal stromal cells in children and adolescents with steroid-refractory graft-versus-host disease.
Döring, M. and Cabanillas Stanchi, K.M. and Lenglinger, K. and Treuner, C. and Gieseke, F. and Erbacher, A. and Mezger, M. and Vaegler, M. and Schlegel, P.G. and Greil, J. and Bettoni da Cunha Riehm, C. and Faul, C. and Schumm, M. and Lang, P. and Handgretinger, R. and Müller, I.
Stem Cells and Development 30 (5): 234-246. 19 February 2021

A helminth-derived chitinase structurally similar to mammalian chitinase displays immunomodulatory properties in inflammatory lung disease.
Ebner, F. and Lindner, K. and Janek, K. and Niewienda, A. and Malecki, P.H. and Weiss, M.S. and Sutherland, T.E. and Heuser, A. and Kühl, A.A. and Zentek, J. and Hofmann, A. and Hartmann, S.
Journal of Immunology Research 2021 : 234836. 25 November 2021

Cystatin M/E variant causes autosomal dominant keratosis follicularis spinulosa decalvans by dysregulating cathepsins L and V.
Eckl, K.M. and Gruber, R. and Brennan, L. and Marriott, A. and Plank, R. and Moosbrugger-Martinz, V. and Blunder, S. and Schossig, A. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Zschocke, J. and Hennies, H.C. and Schmuth, M.
Frontiers in Genetics 12 : 689940. July 2021

Surface AMP deaminase 2 as a novel regulator modifying extracellular adenine nucleotide metabolism.
Ehlers, L. and Kuppe, A. and Damerau, A. and Wilantri, S. and Kirchner, M. and Mertins, P. and Strehl, C. and Buttgereit, F. and Gaber, T.
FASEB Journal 35 (7): e21684. July 2021

32-channel self-grounded bow-tie transceiver array for cardiac MR at 7.0T.
Eigentler, T.W. and Kuehne, A. and Boehmert, L. and Dietrich, S. and Els, A. and Waiczies, H. and Niendorf, T.
Magnetic Resonance in Medicine 86 (5): 2862-2879. November 2021

Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.
El-Battrawy, I. and Lan, H. and Cyganek, L. and Maywald, L. and Zhong, R. and Zhang, F. and Xu, Q. and Lee, J. and Duperrex, E. and Hierlemann, A. and Saguner, A.M. and Duru, F. and Kovacs, B. and Huang, M. and Liao, Z. and Albers, S. and Müller, J. and Dinkel, H. and Rose, L. and Hohn, A. and Yang, Z. and Qiao, L. and Li, Y. and Lang, S. and Kleinsorge, M. and Mügge, A. and Aweimer, A. and Fan, X. and Diecke, S. and Akin, I. and Li, G. and Zhou, X.
Clinical and Translational Medicine 11 (12): e646. 26 December 2021

Homozygous nonsense mutation of WTN10B gene in a Moroccan family with split-hand foot malformation identified by exome sequencing: a case report.
Elalaoui, S.C. and Fejjal, N. and Li, Y. and Thiele, H. and Altmüller, J. and Guaoua, S. and Nürnberg, P. and Wollnik, B. and Sefiani, A. and Ratbi, I.
Pan African Medical Journal 39 : 21. May 2021

Complex population dynamics in a spatial microbial ecosystem with Physarum polycephalum.
Epstein, L. and Dubois, Z. and Smith, J. and Lee, Y. and Harrington, K.
Biosystems 208 : 104483. October 2021

Complex population dynamics in a spatial microbial ecosystem with Physarum polycephalum.
Epstein, L. and Dubois, Z. and Smith, J. and Lee, Y. and Harrington, K.
bioRxiv : 2021.03.14.435300. 15 March 2021

Transposable elements and introgression introduce genetic variation in the invasive ant Cardiocondyla obscurior.
Errbii, M. and Keilwagen, J. and Hoff, K.J. and Steffen, R. and Altmüller, J. and Oettler, J. and Schrader, L.
Molecular Ecology 30 (23): 6211-6228. December 2021

Base editing repairs an SGCA mutation in human primary muscle stem cells.
Escobar, H. and Krause, A. and Keiper, S. and Kieshauer, J. and Müthel, S. and García de Paredes, M. and Metzler, E. and Kühn, R. and Heyd, F. and Spuler, S.
JCI Insight 6 (10): e145994. 24 May 2021

Expanding the spectrum of FAT1 nephropathies by novel mutations that affect hippo signaling.
Fabretti, F. and Tschernoster, N. and Erger, F. and Hedergott, A. and Buescher, A.K. and Dafinger, C. and Reusch, B. and Köntges, V.K. and Kohl, S. and Bartram, M.P. and Weber, L.T. and Thiele, H. and Altmueller, J. and Schermer, B. and Beck, B.B. and Habbig, S.
Kidney International Reports 6 (5): 1368-1378. May 2021

Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi, Z. and Walde, M. and Klementowicz, A.E. and Paraskevopoulou, F. and Woehler, A.
iScience 24 (1): 101909. 22 January 2021

The role of high-resolution analytical techniques in the development of functional foods.
Fernández-Ochoa, Á. and Leyva-Jiménez, F.J. and De la Luz Cádiz-Gurrea, M. and Pimentel-Moral, S. and Segura-Carretero, A.
International Journal of Molecular Sciences 22 (6): 3220. 22 March 2021

MTBP phosphorylation controls DNA replication origin firing.
Ferreira, P. and Höfer, V. and Kronshage, N. and Marko, A. and Reusswig, K.U. and Tetik, B. and Dießel, C. and Köhler, K. and Tschernoster, N. and Altmüller, J. and Schulze, N. and Pfander, B. and Boos, D.
Scientific Reports 11 (1): 4242. 19 February 2021

Predicting brain-age from raw T(1)-weighted magnetic resonance imaging data using 3D convolutional neural networks.
Fisch, L. and Ernsting, J. and Winter, N.R. and Holstein, V. and Leenings, R. and Beisemann, M. and Sarink, K. and Emden, D. and Opel, N. and Redlich, R. and Repple, J. and Grotegerd, D. and Meinert, S. and Wulms, N. and Minnerup, H. and Hirsch, J.G. and Niendorf, T. and Endemann, B. and Bamberg, F. and Kröncke, T. and Peters, A. and Bülow, R. and Völzke, H. and von Stackelberg, O. and Sowade, R.F. and Umutlu, L. and Schmidt, B. and Caspers, S. and Kugel, H. and Baune, B.T. and Kircher, T. and Risse, B. and Dannlowski, U. and Berger, K. and Hahn, T.
arXiv : 2103.11695. 22 March 2021

The SEQC2 Epigenomics Quality Control (EpiQC) Study: comprehensive characterization of epigenetic methods, reproducibility, and quantification.
Foox, J. and Nordlund, J. and Lalancette, C. and Gong, T. and Lacey, M. and Lent, S. and Langhorst, B.W. and Ponnaluri, V.K.C. and Williams, L. and Padmamabhan, K. and Cavalcante, R. and Lundmark, A. and Butler, D. and Gurvitch, J. and Greally, J.M. and Suzuki, M. and Menor, M. and Nasu, M. and Alonso, A. and Sheridan, C. and Scherer, A. and Bruinsma, S. and Golda, G. and Muszynska, A. and Labaj, P.P. and Campbe, M.A. and Wos, F. and Raine, A. and Liljedahl, U. and Axelsson, T. and Wang, C. and Chen, Z. and Yang, Z. and Li, J. and Yang, X. and Wang, H. and Melnick, A. and Guo, S. and Blume, A. and Franke, V. and Ibanez de Caceres, I. and Rodriguez-Antolin, C. and Rosas, R. and Wade Davis, J. and Ishii, J. and Megherbi, D.B. and Xiao, W. and Liao, W. and Xu, J. and Hong, H. and Ning, B. and Tong, W. and Akalin, A. and Wang, Y. and Wang, Y. and Mason, C.E.
bioRxiv : 2020.12.14.421529. 26 April 2021

The SEQC2 epigenomics quality control (EpiQC) study.
Foox, J. and Nordlund, J. and Lalancette, C. and Gong, T. and Lacey, M. and Lent, S. and Langhorst, B.W. and Ponnaluri, V.K.C. and Williams, L. and Padmanabhan, K.R. and Cavalcante, R. and Lundmark, A. and Butler, D. and Mozsary, C. and Gurvitch, J. and Greally, J.M. and Suzuki, M. and Menor, M. and Nasu, M. and Alonso, A. and Sheridan, C. and Scherer, A. and Bruinsma, S. and Golda, G. and Muszynska, A. and Łabaj, P.P. and Campbell, M.A. and Wos, F. and Raine, A. and Liljedahl, U. and Axelsson, T. and Wang, C. and Chen, Z. and Yang, Z. and Li, J. and Yang, X. and Wang, H. and Melnick, A. and Guo, S. and Blume, A. and Franke, V. and Ibanez de Caceres, I. and Rodriguez-Antolin, C. and Rosas, R. and Davis, J.W. and Ishii, J. and Megherbi, D.B. and Xiao, W. and Liao, W. and Xu, J. and Hong, H. and Ning, B. and Tong, W. and Akalin, A. and Wang, Y. and Deng, Y. and Mason, C.E.
Genome Biology 22 (1): 332. 6 December 2021

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and aging.
Freitag, K. and Eede, P. and Ivanov, A. and Schneeberger, S. and Borodina, T. and Sauer, S. and Beule, D. and Heppner, F.L.
bioRxiv : 2021.08.02.454573v1. 28 November 2021

Dissecting herpes simplex virus 1-induced host shutoff at the RNA level.
Friedel, C.C. and Whisnant, A.W. and Djakovic, L. and Rutkowski, A.J. and Friedl, M.S. and Kluge, M. and Williamson, J.C. and Sai, S. and Vidal, R.O. and Sauer, S. and Hennig, T. and Grothey, A. and Milić, A. and Prusty, B.K. and Lehner, P.J. and Matheson, N.J. and Erhard, F. and Dölken, L.
Journal of Virology 95 (3): e01399-20. 13 January 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C. and Schallenberg, S. and Kirchner, M. and Ziehm, M. and Niquet, S. and Haji, M. and Beier, C. and Neudecker, J. and Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

Optimized workflow for on-line derivatization for targeted metabolomics approach by gas chromatography-mass spectrometry.
Fritsche-Guenther, R. and Gloaguen, Y. and Bauer, A. and Opialla, T. and Kempa, S. and Fleming, C.A. and Redmond, H.P. and Kirwan, J.A.
Metabolites 11 (12): 888. 18 December 2021

Parallel genetics of regulatory sequences using scalable genome editing in vivo.
Froehlich, J.J. and Uyar, B. and Herzog, M. and Theil, K. and Glažar, P. and Akalin, A. and Rajewsky, N.
Cell Reports 35 (2): 108988. 13 April 2021

Human brain organoids assemble functionally integrated bilateral optic vesicles.
Gabriel, E. and Albanna, W. and Pasquini, Gi. and Ramani, A. and Josipovic, N. and Mariappan, A. and Schinzel, F. and Karch, C.M. and Bao, G. and Gottardo, M. and Suren, A.A. and Hescheler, J. and Nagel-Wolfrum, K. and Persico, V. and Rizzoli, S.O. and Altmüller, J. and Riparbelli, M.G. and Callaini, G. and Goureau, O. and Papantonis, A. and Busskamp, V. and Schneider, T. and Gopalakrishnan, J.
Cell Stem Cell 28 (10): 1740-1757.e8. October 2021

Intellectual disability associated with craniofacial dysmorphism, cleft palate, and congenital heart defect due to a de novo MEIS2 mutation: a clinical longitudinal study.
Gangfuß, A. and Yigit, G. and Altmüller, J. and Nürnberg, P. and Czeschik, J.C. and Wollnik, B. and Bögershausen, N. and Burfeind, P. and Wieczorek, D. and Kaiser, F. and Roos, A. and Kölbel, H. and Schara-Schmidt, U. and Kuechler, A.
American Journal of Medical Genetics A 185 (4): 1216-1221. April 2021

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S. and Bartolomaeus, H. and Neubert, P. and Willebrand, R. and Zasada, C. and Bartolomaeus, T. and McParland, V. and Swinnen, D. and Geuzens, A. and Maifeld, A. and Krampert, L. and Vogl, M. and Mähler, A. and Wilck, N. and Marko, L. and Tilic, E. and Forslund, S.K. and Binger, K.J. and Stegbauer, J. and Dechend, R. and Kleinewietfeld, M. and Jantsch, J. and Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Stein, J. and Dey, H.P. and Paclik, D. and Mülleder, M. and Aulakh, S.K. and Mei, H.E. and Schulz, A.R. and Hippenstiel, S. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer-Wasserscheid, B. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
medRxiv : 2021.06.08.21258481. 11 June 2021

A novel remitting leukodystrophy associated with a variant in FBP2.
Gizak, A. and Diegmann, S. and Dreha-Kulaczewski, S. and Wiśniewski, J. and Duda, P. and Ohlenbusch, A. and Huppke, B. and Henneke, M. and Höhne, W. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Rakus, D. and Gärtner, J. and Huppke, P.
Brain Communications 3 (2): fcab036. 11 March 2021

Reliable kidney size determination by magnetic resonance imaging in pathophysiological settings.
Gladytz, T. and Millward, J.M. and Cantow, K. and Hummel, Luis and Zhao, K. and Flemming, B. and Periquito, J.S. and Pohlmann, A. and Waiczies, S. and Seeliger, E. and Niendorf, T.
Acta Physiologica 233 (2): e13701. October 2021

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.
Goetzke, C.C. and Althof, N. and Neumaier, H.L. and Heuser, A. and Kaya, Z. and Kespohl, M. and Klingel, K. and Beling, A.
Basic Research in Cardiology 116 (1): 7. 1 February 2021

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing.
Goulielmaki, E. and Tsekrekou, M. and Batsiotos, N. and Ascensão-Ferreira, M. and Ledaki, E. and Stratigi, K. and Chatzinikolaou, G. and Topalis, P. and Kosteas, T. and Altmüller, J. and Demmers, J.A. and Barbosa-Morais, N.L. and Garinis, G.A.
Nature Communications 12 (1): 3153. 26 May 2021

Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K. and Fogo, M.S. and Pinto, B.G.G. and Alves, A.Y. and Suzuki, A.M. and Morales, A.G. and Ezquina, S. and Sosa, O.J. and Sutton, G.J. and Sunaga-Franze, D.Y. and Bueno, A.P. and Seabra, G. and Sardinha, L. and Costa, S.S. and Rosenberg, C. and Zachi, E.C. and Sertie, A.L. and Martins-de-Souza, D. and Reis, E.M. and Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26 (5): 1589-1605. May 2021

Natural compounds and synthetic drugs to target type-2 cannabinoid (CB(2)) receptor.
Guba, W. and Nazaré, M. and Grether, U.
In: New tools to interrogate endocannabinoid signalling : from natural compounds to synthetic drugs. RSC Drug Discovery Series, 76 . Royal Society of Chemistry, Croydon, 89-167. ISBN 978-1-78801-801-2 2021

Bionic tracking: using eye tracking to track biological cells in virtual reality.
Günther, U. and Harrington, K.I.S. and Dachselt, R. and Sbalzarini, I.F.
Lecture Notes in Computer Science 12535 : 280-297. 2021

Multi-channel RF supervision module for thermal magnetic resonance based cancer therapy.
Han, H. and Oberacker, E. and Kuehne, A. and Wang, S. and Eigentler, T.W. and Grass, E. and Niendorf, T.
Cancers 13 (5): 1001. 28 February 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A. and Sieverling, L. and Nadler-Holly, M. and Ziehm, M. and Toprak, U.H. and Herrmann, C. and Ishaque, N. and Okonechnikov, K. and Gartlgruber, M. and Park, Y.G. and Wecht, E.M. and Savelyeva, L. and Henrich, K.O. and Rosswog, C. and Fischer, M. and Hero, B. and Jones, D.T.W. and Pfaff, E. and Witt, O. and Pfister, S.M. and Volckmann, Ri. and Koster, J. and Kiesel, K. and Rippe, K. and Taschner-Mandl, S. and Ambros, P. and Brors, B. and Selbach, M. and Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Artificially produced gametes in mice, humans and other species.
Hayashi, K. and Galli, C. and Diecke, S. and Hildebrandt, T.B.
Reproduction Fertility and Development 33 (2): 91-101. 8 January 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S. and Heimann, A. and Obermayer, B. and Ciraolo, E. and Althoff, S. and Ruß, J. and Grunert, C. and Busse, A. and Bullinger, L. and Pezzutto, A. and Blankenstein, T. and Beule, D. and Na, I.K.
International Journal of Cancer 148 (12): 3097-3110. 15 June 2021

Simultaneous T(2) and T(2)* mapping of multiple sclerosis lesions with radial RARE-EPI.
Herrmann, C. and Els, A. and Boehmert, L. and Periquito, J. and Eigentler, T.W. and Millward, J. and Waiczies, S. and Kuchling, J. and Paul, F. and Niendorf, T.
Magnetic Resonance in Medicine 86 (3): 1383-1402. September 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

The ART of bringing extinction to a freeze - history and future of species conservation, exemplified by rhinos.
Hildebrandt, T.B. and Hermes, R. and Goeritz, F. and Appeltant, R. and Colleoni, S. and de Mori, B. and Diecke, S. and Drukker, M. and Galli, C. and Hayashi, K. and Lazzari, G. and Loi, P. and Payne, J. and Renfree, M. and Seet, S. and Stejskal, J. and Swegen, A. and Williams, S.A. and Zainuddin, Z.Z. and Holtze, S.
Theriogenology 169 : 76-88. 15 July 2021

Conservation research in times of COVID-19 - the rescue of the northern white rhino.
Hildebrandt, T.B. and Holtze, S. and Biasetti, P. and Colleoni, S. and de Mori, B. and Diecke, S. and Göritz, F. and Hayashi, K. and Hayashi, M. and Hermes, R. and Kariuki, L. and Lazzari, G. and Mijele, D. and Mutisya, S. and Ndeereh, D. and Ngulu, S. and Seet, S. and Zwilling, J. and Zywitza, V. and Stejskal, J. and Galli, C.
Journal of Applied Animal Ethics Research 3 (1): 16-37. May 2021

Expression of a modified astrocytic glutamate transporter alleviates Huntington’s hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions.
Hirschberg, S. and Dvorzhak, A. and Rasooli-Nejad, S.M.A. and Angelov, S. and Kirchner, M. and Mertins, P. and Lättig-Tünnemann, G. and Harms, C. and Schmitz, D. and Grantyn, R.
bioRxiv : 2020.09.17.302158. 26 March 2021

A prospective of multiple biopharmaceutical activities of procyanidins‐rich Uapaca togoensis pax extracts: HPLC‐ESI‐TOF‐MS coupled with bioinformatics analysis.
Ibrahime Sinan, K. and Aktumsek, A. and de la Luz Cádiz‐Gurrea, M. and Leyva‐Jiménez, F.J. and Fernández-Ochoa, Á. and Segura‐Carretero, A. and Glamocilja, J. and Sokovic, M. and Nenadić, M. and Zengin, G.
Chemistry & Biodiversity 18 (8): e2100299. 18 August 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F. and Dahlmann, M. and Sporbert, A. and Ciolli Mattioli, C. and Mari, T. and Scholz, F. and Timm, L. and Twamley, S. and Migotti, R. and Walther, W. and Dittmar, G. and Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies.
Iqbal, M. and Maroofian, R. and Çavdarlı, B. and Riccardi, F. and Field, M. and Banka, S. and Bubshait, D.K. and Li, Y. and Hertecant, J. and Baig, S.M. and Dyment, D. and Efthymiou, S. and Abdullah, U. and Makhdoom, E.U.H. and Ali, Z. and Scherf de Almeida, T and Molinari, F. and Mignon-Ravix, C. and Chabrol, B. and Antony, J. and Ades, L. and Pagnamenta, A.T. and Jackson, A. and Douzgou, S. and Beetz, C. and Karageorgou, V. and Vona, B. and Rad, A. and Baig, J.M. and Sultan, T. and Alvi, J.R. and Maqbool, S. and Rahman, F. and Toosi, M.B. and Ashrafzadeh, F. and Imannezhad, S. and Karimiani, E.G. and Sarwar, Y. and Khan, S. and Jameel, M. and Noegel, A.A. and Budde, B. and Altmüller, J. and Motameny, S. and Höhne, W. and Houlden, H. and Nürnberg, P. and Wollnik, B. and Villard, L. and Alkuraya, F.S. and Osmond, M. and Hussain, M.S. and Yigit, G.
Genetics in Medicine 23 (11): 2138-2149. November 2021

Dolosigranulum pigrum modulates immunity against SARS-CoV-2 in respiratory epithelial cells.
Islam, M.A. and Albarracin, L. and Melnikov, V. and Andrade, B.G.N. and Cuadrat, R.R.C. and Kitazawa, H. and Villena, J.
Pathogens 10 (6): 634. 21 May 2021

Immunobiotic Lactobacilli improve resistance of respiratory epithelial cells to SARS-CoV-2 infection.
Islam, M.A. and Albarracin, L. and Tomokiyo, M. and Valdez, J.C. and Sacur, J. and Vizoso-Pinto, M.G. and Andrade, B.G.N. and Cuadrat, R.C. and Kitazawa, H. and Villena, J.
Pathogens 10 (9): 1197. September 2021

Analysis of renal diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models.
Jerome, N.P. and Periquito, J.S.
Methods in Molecular Biology 2216 : 611-635. 2021

Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser, R. and Leunig, A. and Pekayvaz, K. and Popp, O. and Joppich, M. and Polewka, V. and Escaig, R. and Anjum, A. and Hoffknecht, M.L. and Gold, C. and Brambs, S. and Engel, A. and Stockhausen, S. and Knottenberg, V. and Titova, A. and Haji, M. and Scherer, C. and Muenchhoff, M. and Hellmuth, J.C. and Saar, K. and Schubert, B. and Hilgendorff, A. and Schulz, C. and Kääb, S. and Zimmer, R. and Hübner, N. and Massberg, S. and Mertins, P. and Nicolai, L. and Stark, K.
JCI Insight 6 (18): e150862. 22 September 2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Kargapolova, Y. and Rehimi, R. and Kayserili, H. and Brühl, J. and Sofiadis, K. and Zirkel, A. and Palikyras, S. and Mizi, A. and Li, Y. and Yigit, G. and Hoischen, A. and Frank, S. and Russ, N. and Trautwein, J. and van Bon, B. and Gilissen, C. and Laugsch, M. and Gusmao, E.G. and Josipovic, N. and Altmüller, J. and Nürnberg, P. and Längst, G. and Kaiser, F.J. and Watrin, E. and Brunner, H. and Rada-Iglesias, A. and Kurian, L. and Wollnik, B. and Bouazoune, K. and Papantonis, A.
Nature Communications 12 (1): 3014. 21 May 2021

Preparation and monitoring of small animals in renal MRI.
Kaucsar, T. and Hosszu, A. and Seeliger, E. and Reimann, H.M. and Fekete, A.
Methods in Molecular Biology 2216 : 45-55. 2021

Genomic variants causing mitochondrial dysfunction are common in hereditary lower motor neuron disease.
Keller, N. and Paketci, C. and Altmueller, J. and Fuhrmann, N. and Wunderlich, G. and Schrank, B. and Unver, O. and Yilmaz, S. and Boostani, R. and Karimiani, E.G. and Motameny, S. and Thiele, H. and Nürnberg, P. and Maroofian, R. and Yis, U. and Wirth, Br. and Karakaya, M.
Human Mutation 42 (4): 460-472. April 2021

Profiling of sub-lethal in vitro effects of multi-walled carbon nanotubes reveals changes in chemokines and chemokine receptors.
Keshavan, S. and Andón, F.T. and Gallud, A. and Chen, W. and Reinert, K. and Tran, L. and Fadeel, B.
Nanomaterials 11 (4): 883. 30 March 2021

MFSD2A-associated primary microcephaly - expanding the clinical and mutational spectrum of this ultra-rare disease.
Khuller, K. and Yigit, G. and Martínez Grijalva, C. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Elcioglu, N.H. and Yeter, B. and Hehr, U. and Stein, A. and Della Marina, A. and Köninger, A. and Depienne, C. and Kaiser, F.J. and Wollnik, B. and Kuechler, A.
European Journal of Medical Genetics 64 (10): 104310. October 2021

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.
Kircher, T. and Pantsar, T. and Oder, A. and von Kries, J.P. and Juchum, M. and Pfaffenrot, B. and Kloevekorn, P. and Albrecht, W. and Selig, R. and Laufer, S.
European Journal of Medicinal Chemistry 2019 : 112901. 1 January 2021

ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIF–containing protein that controls root growth angle in barley and wheat.
Kirschner, G.K. and Rosignoli, S. and Guo, L. and Vardanega, I. and Imani, J. and Altmüller, J. and Milner, S.G. and Balzano, R: and Nagel, K.A. and Pflugfelder, D. and Forestan, C. and Bovina, R. and Koller, R. and Stöcker, T.G. and Mascher, M. and Simmonds, J. and Uauy, C. and Schoof, H. and Tuberosa, R. and Salvi, S. and Hochholdinger, F.
Proceedings of the National Academy of Sciences of the United States of America 118 (35): e2101526118. 31 August 2021

ANK3 related neurodevelopmental disorders: expanding the spectrum of heterozygous loss-of-function variants.
Kloth, K. and Lozic, B. and Tagoe, J. and Hoffer, M.J.V. and Van der Ven, A. and Thiele, H. and Altmüller, J. and Kubisch, C. and Au, P.Y.B. and Denecke, J. and Bijlsma, E.K. and Lessel, D.
Neurogenetics 22 (4): 263-269. October 2021

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis.
Kobelt, D. and Perez-Hernandez, D. and Fleuter, C. and Dahlmann, M. and Zincke, F. and Smith, J. and Migotti, R. and Popp, O. and Burock, S. and Walther, W. and Dittmar, G. and Mertins, P. and Stein, U.
Oncogene 40 (34): 5286-5301. 26 August 2021

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.
Koester, J. and Miroshnikova, Y.A. and Ghatak, S. and Chacón-Martínez, C.A. and Morgner, J. and Li, X. and Atanassov, I. and Altmüller, J. and Birk, D.E. and Koch, M. and Bloch, W. and Bartusel, M. and Niessen, C.M. and Rada-Iglesias, A. and Wickström, S.A.
Nature Cell Biology 23 (7): 771-781. July 2021

An identical-by-descent novel splice-donor variant in PRUNE1 causes a neurodevelopmental syndrome with prominent dystonia in two consanguineous Sudanese families.
Koko, M. and Yahia, A. and Elsayed, L.E. and Hamed, A.A. and Mohammed, I.N. and Elseed, M.A. and Hamad, M.H.A. and Babai, A.M. and Siddig, R.A. and Abd Allah, A.S.I. and Mohamed, M. and El-Amin, M. and Esteves, T. and Altmüller, J. and Toliat, M.R. and Thiele, H. and Nürnberg, P. and Salih, M.A. and Ahmed, A.E. and Lerche, H. and Stevanin, G.
Annals of Human Genetics 85 (5): 186-195. September 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W. and Akalin, A. and Ohler, U.
bioRxiv : 2021.05.11.443540. 12 May 2021

Effects of daytime dry fasting on hydration, glucose metabolism and circadian phase: a prospective exploratory cohort study in Bahá'í volunteers.
Koppold-Liebscher, D.A. and Klatte, C. and Demmrich, S. and Schwarz, J. and Kandil, F.I. and Steckhan, N. and Ring, R. and Kessler, C.S. and Jeitler, M. and Koller, B. and Ananthasubramaniam, B. and Eisenmann, C. and Mähler, A. and Boschmann, M. and Kramer, A. and Michalsen, A.
Frontiers in Nutrition 8 : 662310. July 2021

Computational approaches to predicting treatment response to obesity using neuroimaging.
Kozarzewski, L. and Maurer, L. and Mähler, A. and Spranger, J. and Weygandt, M.
Reviews in Endocrine & Metabolic Disorders 23 (4): 773–805. August 2021

A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse.
Krause, F. and Mohebian, K. and Delpero, M. and Hesse, D. and Kuehn, R. and Arends, D. and Brockmann, G.A.
Mammalian Genome 33 (3): 465–470. September 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Harnett, D. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Günnigmann, M. and Zinnall, U. and Vieira-Vieira, C.H. and Schaub, T. and Münster-Wandowski, A. and Bürger, J. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Ohler, U. and Beule, D. and Mielke, T. and Tarabykin, V. and Landthaler, M. and Kramer, G. and Vida, I. and Selbach, M. and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B. and Knoll, R. and Bonaguro, L. and ToVinh, M. and Raabe, J. and Astaburuaga-García, R. and Schulte-Schrepping, J. and Kaiser, K.M. and Rieke, G.J. and Bischoff, J. and Monin, M.B. and Hoffmeister, C. and Schlabe, S. and De Domenico, E. and Reusch, N. and Händler, K. and Reynolds, G. and Blüthgen, N. and Hack, G. and Finnemann, C. and Nischalke, H.D. and Strassburg, C.P. and Stephenson, E. and Su, Y. and Gardner, L. and Yuan, D. and Chen, D. and Goldman, J. and Rosenstiel, P. and Schmidt, S.V. and Latz, E. and Hrusovsky, K. and Ball, A.J. and Johnson, J.M. and Koenig, P.A. and Schmidt, F.I. and Haniffa, M. and Heath, J.R. and Kümmerer, B.M. and Keitel, V. and Jensen, B. and Stubbemann, P. and Kurth, F. and Sander, L.E. and Sawitzki, B. and Aschenbrenner, A.C. and Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Noninvasive renal perfusion measurement using arterial spin labeling (ASL) MRI: basic concept.
Ku, M.C. and Fernández-Seara, M.A. and Kober, F. and Niendorf, T.
Methods in Molecular Biology 2216 : 229-239. 2021

Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy.
Ku, M.C. and Kober, F. and Lai, Y.C. and Pohlmann, A. and Qadri, F. and Bader, M. and Carrier, L. and Niendorf, T.
Journal of Cardiovascular Magnetic Resonance 23 (1): 63. 31 May 2021

Fluorine ((19)F) MRI for assessing inflammatory cells in the kidney: experimental protocol.
Ku, M.C. and Schreiber, A. and Delgado, P.R. and Boehm-Sturm, P. and Kettritz, R. and Niendorf, T. and Pohlmann, A. and Waiczies, S.
Methods in Molecular Biology 2216 : 495-507. 2021

Generation of human brain organoids for mitochondrial disease modeling.
Le, S. and Petersilie, L. and Inak, G. and Menacho-Pando, C. and Kafitz, K.W. and Rybak-Wolf, A. and Rajewsky, N. and Rose, C.R. and Prigione, A.
Journal of Visualized Experiments (172): e62756. 21 June 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Development of a 1,2,4-triazole-based lead tankyrase inhibitor: part II.
Leenders, R.G.G. and Brinch, S.A. and Sowa, S.T. and Amundsen-Isaksen, E. and Galera-Prat, A. and Murthy, S. and Aertssen, S. and Smits, J.N. and Nieczypor, P. and Damen, E. and Wegert, A. and Nazaré, M. and Lehtiö, L. and Waaler, J. and Krauss, S.
Journal of Medicinal Chemistry 64 (24): 17936-17949. 23 December 2021

Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing.
Leiz, J. and Hinze, C. and Boltengagen, A. and Braeuning, C. and Kocks, C. and Rajewsky, N. and Schmidt-Ott, K.M.
Journal of Visualized Experiments (175): e62901. September 2021

Predicting lethal courses in critically ill COVID-19 patients using a machine learning model trained on patients with non-COVID-19 viral pneumonia.
Lichtner, G. and Balzer, F. and Haufe, S. and Giesa, N. and Schiefenhövel, F. and Schmieding, M. and Jurth, C. and Kopp, W. and Akalin, A. and Schaller, S.J. and Weber-Carstens, S. and Spies, C. and von Dincklage, F.
Scientific Reports 11 (1): 13205. 24 June 2021

Resting state brain network functional connectivity is not associated with inflammatory markers and blood cell counts in older adults.
Lichtner, G. and Zacharias, N. and Spies, C.D. and Feinkohl, I. and Winterer, G. and Pischon, T. and von Dincklage, F.
Clinical Neurophysiology 132 (7): 1677-1686. July 2021

hiPSC-derived epidermal keratinocytes from ichthyosis patients show altered expression of cornification markers.
Lima Cunha, D. and Oram, A. and Gruber, R. and Plank, R. and Lingenhel, A. and Gupta, M.K. and Altmüller, J. and Nürnberg, P. and Schmuth, M. and Zschocke, J. and Šarić, T. and Eckl, K.M. and Hennies, H.C.
International Journal of Molecular Sciences 22 (4): 1785. 2 February 2021

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1.
Lo, A. and Holmes, K. and Kamlapurkar, S. and Mundt, F. and Moorthi, S. and Fung, I. and Fereshetian, S. and Watson, J. and Carr, S.A. and Mertins, P. and Berger, A.H.
Science Signaling 14 (711): eabc4520. 30 November 2021

Microglia sense neuronal activity via GABA in the early postnatal hippocampus.
Logiacco, F. and Xia, P. and Georgiev, S.V. and Franconi, C. and Chang, Y.J. and Ugursu, B. and Sporbert, A. and Kühn, R. and Kettenmann, H. and Semtner, M.
Cell Reports 37 (13): 110128. 28 December 2021

Photocaged Hoechst enables subnuclear visualization and cell selective staining of DNA in vivo.
Lämmle, C.A. and Varady, A. and Müller, T.G. and Sturtzel, C. and Riepl, M. and Mathes, B. and Eichhorst, J. and Sporbert, A. and Lehmann, M. and Kräusslich, H.G. and Distel, M. and Broichhagen, J.
ChemBioChem 22 (3): 548-556. 2 February 2021

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S. and Koch, K. and Schriever, C. and Xu, J. and Steinecker, M. and Leber, J. and Dworatzek, E. and Purfürst, B. and Kunz, S. and Recchia, D. and Canepari, M. and Heuser, A. and Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12 : 1249-1265. 14 October 2021

Modifier genes in microcephaly: a report on WDR62, CEP63, RAD50 and PCNT variants exacerbating disease caused by biallelic mutations of ASPM and CENPJ.
Makhdoom, E.U.H. and Waseem, S.S. and Iqbal, M. and Abdullah, U. and Hussain, G. and Asif, M. and Budde, B. and Höhne, W. and Tinschert, S. and Saadi, S.M. and Yousaf, H. and Ali, Z. and Fatima, A. and Kaygusuz, E. and Khan, A. and Jameel, M. and Khan, S. and Tariq, M. and Anjum, I. and Altmüller, J. and Thiele, H. and Höning, S. and Baig, S.M. and Nürnberg, P. and Hussain, M.S.
Genes 12 (5): 731. May 2021

Lipid metabolite biomarkers in cardiovascular disease: discovery and biomechanism translation from human studies.
McGranaghan, P. and Kirwan, J.A. and Garcia-Rivera, M.A. and Pieske, B. and Edelmann, F. and Blaschke, F. and Appunni, S. and Saxena, A. and Rubens, M. and Veledar, E. and Trippel, T.D.
Metabolites 11 (9): 621. September 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.
Mecklenburg, N. and Kowalczyk, I. and Witte, F. and Görne, J. and Laier, A. and Mamo, T.M. and Gonschior, H. and Lehmann, M. and Richter, M. and Sporbert, A. and Purfürst, B. and Hübner, N. and Hammes, A.
Development 148 (17): dev199307. September 2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L. and Zschummel, M. and Crowley, T. and Franke, V. and Grau, M. and Ulbricht, C. and Hauser, A. and Siffrin, V. and Bajénoff, M. and Acton, S.E. and Akalin, A. and Lenz, G. and Willimsky, G. and Höpken, U.E. and Rehm, A.
Cell Reports 37 (4): 109878. 26 October 2021

PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
Messerschmidt, C. and Foddis, M. and Blumenau, S. and Müller, S. and Bentele, K. and Holtgrewe, M. and Kun-Rodrigues, C. and Alonso, I. and do Carmo Macario, M. and Morgadinho, A.S. and Velon, A.G. and Santo, G. and Santana, I. and Mönkäre, S. and Kuuluvainen, L. and Schleutker, J. and Pöyhönen, M. and Myllykangas, L. and Senatore, A. and Berchtold, D. and Winek, K. and Meisel, A. and Pavlovic, A. and Kostic, V. and Dobricic, V. and Lohmann, E. and Hanagasi, H. and Guven, G. and Bilgic, B. and Bras, J. and Guerreiro, R. and Beule, D. and Dirnagl, U. and Sassi, C.
Scientific Reports 11 (1): 6072. 16 March 2021

Preparation of ex vivo rodent phantoms for developing, testing, and training MR imaging of the kidney and other organs.
Millward, J.M. and Periquito, J.S. and Delgado, P.R. and Prinz, C. and Niendorf, T. and Waiczies, S.
Methods in Molecular Biology 2216 : 75-85. 2021

Abrogating GPT2 in triple negative breast cancer inhibits tumor growth and promotes autophagy.
Mitra, D. and Vega-Rubin-de-Celis, S. and Royla, N. and Bernhardt, S. and Wilhelm, H. and Tarade, N. and Poschet, G. and Buettner, M. and Binenbaum, I. and Borgoni, S. and Vetter, M. and Kantelhardt, E.J. and Thomssen, C. and Chatziioannou, A. and Hell, R. and Kempa, S. and Müller-Decker, K. and Wiemann, S.
International Journal of Cancer 148 (8): 1993-2009. 15 April 2021

Phenylalanine-hydroxylase contributes to serotonin synthesis in mice.
Mordhorst, A. and Dhandapani, P. and Matthes, S. and Mosienko, V. and Rothe, M. and Todiras, M. and Self, J. and Schunck, W.H. and Schütz, A. and Bader, M. and Alenina, N.
FASEB Journal 35 (6): e21648. June 2021

Metabolic response to daytime dry fasting in Bahá'í volunteers -- results of a preliminary study.
Mähler, A. and Jahn, C. and Klug, L. and Klatte, C. and Michalsen, A. and Koppold-Liebscher, D. and Boschmann, M.
Nutrients 14 (1): 148. 29 December 2021

Ophthalmic magnetic resonance imaging: where are we (heading to)?
Niendorf, T. and Beenakker, J.W.M. and Langner, S. and Erb-Eigner, K. and Bach Cuadra, M. and Beller, E. and Millward, J.M. and Niendorf, T.M. and Stachs, O.
Current Eye Research 46 (9): 1251-1270. September 2021

Preface.
Niendorf, T. and Pohlmann, A.
Methods in Molecular Biology 2216 : v-vi. 2021

Maternal angiotensin increases placental leptin in early gestation via an alternative renin-angiotensin system pathway: suggesting a link to preeclampsia.
Nonn, O. and Fischer, C. and Geisberger, S. and El-Heliebi, A. and Kroneis, T. and Forstner, D. and Desoye, G. and Staff, A.C. and Sugulle, M. and Dechend, R. and Pecks, U. and Kollmann, M. and Stern, C. and Cartwright, J.E. and Whitley, G.S. and Thilaganathan, B. and Wadsack, C. and Huppertz, B. and Herse, F. and Gauster, M.
Hypertension 77 (5): 1723-1736. May 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Muelleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

Longitudinal omics in Syrian hamsters integrated with human data unravel cellular effector responses to moderate COVID-19.
Nouailles, Geraldine and Wyler, E. and Pennitz, P. and Postmus, D. and Vladrimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M.l and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Research Square : rs-148392/v1. 28 January 2021

Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens.
Numberger, D. and Zoccarato, L. and Woodhouse, J. and Ganzert, L. and Sauer, S. and Grossart, H.P. and Greenwood, A.D.
bioRxiv : 2020.06.26.173328. 8 November 2021

Improvement in the prediction of neonatal hypoxic-ischemic encephalopathy with the integration of umbilical cord metabolites and current clinical makers.
O'Boyle, D.S. and Dunn, W.B. and O'Neill, D. and Kirwan, J.A. and Broadhurst, D.I. and Hallberg, B. and Boylan, G.B. and Murray, D.M.
Journal of Pediatrics 229 : 175-181. February 2021

Patient-specific planning for thermal magnetic resonance of glioblastoma multiforme.
Oberacker, E. and Diesch, C. and Nadobny, J. and Kuehne, A. and Wust, P. and Ghadjar, P. and Niendorf, T.
Cancers 13 (8): 1867. 2 April 2021

A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Ostrop, J. and Zwiggelaar, R.T. and Terndrup Pedersen, M. and Gerbe, F. and Bösl, K. and Lindholm, H.T. and Díez-Sánchez, A. and Parmar, N. and Radetzki, S. and von Kries, J.P. and Jay, P. and Jensen, K.B. and Arrowsmith, C. and Oudhoff, M.J.
Frontiers in Cell and Developmental Biology 8 : 618552. 21 January 2021

Altered DNA methylation profiles in SF3B1 mutated CLL patients.
Pacholewska, A. and Grimm, C. and Herling, C.D. and Lienhard, M. and Königs, A. and Timmermann, B. and Altmüller, J. and Mücke, O. and Reinhardt, H.C. and Plass, C. and Herwig, R. and Hallek, M. and Schweiger, M.R.
International Journal of Molecular Sciences 22 (17): 9337. 1 September 2021

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K. and Leunig, A. and Kaiser, R. and Brambs, S. and Joppich, M. and Janjic, A. and Popp, O. and Polewka, V. and Wange, L.E. and Gold, C. and Kirchner, M. and Muenchhoff, M. and Hellmuth, J.C. and Scherer, C. and Eser, T. and Deák, F. and Kuhl, N. and Linder, A. and Saar, K. and Tomas, L. and Schulz, C. and Enard, W. and Kroidl, I. and Geldmacher, C. and von Bergwelt-Baildon, M. and Keppler, O.T. and Zimmer, R. and Mertins, P. and Hubner, N. and Hölscher, M. and Massberg, S. and Stark, K. and Nicolai, L.
bioRxiv : 2021.02.03.429351. 3 February 2021

Community-wide experimental evaluation of the PROSS stability-design method.
Peleg, Y. and Vincentelli, R. and Collins, B.M. and Chen, K.E. and Livingstone, E.K. and Weeratunga, S. and Leneva, N. and Guo, Q. and Remans, K. and Perez, K. and Bjerga, G.E.K. and Larsen, Ø. and Vaněk, O. and Skořepa, O. and Jacquemin, S. and Poterszman, A. and Kjaer, S. and Christodoulou, E. and Albeck, S. and Dym, O. and Ainbinder, E. and Unger, T. and Schuetz, A. and Matthes, S. and Bader, M. and de Marco, A. and Storici, P. and Semrau, M.S. and Stolt-Bergner, P. and Aigner, C. and Suppmann, S. and Goldenzweig, A. and Fleishman, S.J.
Journal of Molecular Biology 433 (13): 166964. 25 June 2021

Continuous diffusion spectrum computation for diffusion-weighted magnetic resonance imaging of the kidney tubule system.
Periquito, J.S. and Gladytz, T. and Millward, J.M. and Delgado, P.R. and Cantow, K. and Grosenick, D. and Hummel, L. and Anger, A. and Zhao, K. and Seeliger, E. and Pohlmann, A. and Waiczies, S. and Niendorf, T.
Quantitative Imaging in Medicine and Surgery 11 (7): 3098-3119. July 2021

Renal MRI diffusion: experimental protocol.
Periquito, J.S. and Meier, M. and Niendorf, T. and Pohlmann, A. and Jerome, N.P.
Methods in Molecular Biology 2216 : 419-428. 2021

Analysis protocols for MRI mapping of the blood oxygenation-sensitive parameters T(2)* and T(2) in the kidney.
Periquito, J.S. and Starke, L. and Santos, C.M. and Freitas, A.C. and Loução, N. and Polo, P.G. and Nunes, R.G. and Niendorf, T. and Pohlmann, A.
Methods in Molecular Biology 2216 : 591-610. 2021

Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis.
Perne, C. and Peters, S. and Cartolano, M. and Horpaopan, S. and Grimm, C. and Altmüller, J. and Sommer, A.K. and Hillmer, A.M. and Thiele, H. and Odenthal, M. and Möslein, G. and Adam, R. and Sivalingam, S. and Kirfel, J. and Schweiger, M.R. and Peifer, M. and Spier, I. and Aretz, S.
PLoS ONE 16 (11): e0259185. 29 November 2021

An expanded polyproline domain maintains mutant huntingtin soluble in vivo and during aging.
Pigazzini, M.L. and Lawrenz, M. and Margineanu, A. and Kaminski Schierle, G.S. and Kirstein, J.
Frontiers in Molecular Neuroscience 14 : 721749. 15 October 2021

Identification and characterization of human observational studies in nutritional epidemiology on gut microbiomics for joint data analysis.
Pinart, M. and Nimptsch, K. and Forslund, S.K. and Schlicht, K. and Gueimonde, M. and Brigidi, P. and Turroni, S. and Ahrens, W. and Hebestreit, A. and Wolters, M. and Dötsch, A. and Nöthlings, U. and Oluwagbemigun, K. and Cuadrat, R.R.C. and Schulze, M.B. and Standl, M. and Schloter, M. and De Angelis, M. and Iozzo, P. and Guzzardi, M.A. and Vlaemynck, G. and Penders, J. and Jonkers, D.M.A.E. and Stemmer, M. and Chiesa, G. and Cavalieri, D. and De Filippo, C. and Ercolini, D. and De Filippis, F. and Ribet, D. and Achamrah, N. and Tavolacci, M.P. and Déchelotte, P. and Bouwman, J. and Laudes, M. and Pischon, T.
Nutrients 13 (9): 3292. September 2021

Exploration of analgesia with tramadol in the Coxsackievirus B3 myocarditis mouse model.
Pinkert, S. and Kespohl, M. and Kelm, N. and Kaya, Z. and Heuser, A. and Klingel, K. and Beling, A.
Viruses 13 (7): 1222. 24 June 2021

BMI and mortality - time to revisit current recommendations for risk assessment.
Pischon, T.
American Journal of Clinical Nutrition 113 (1): 3-4. January 2021

Recommendations for preclinical renal MRI: a comprehensive open-access protocol collection to improve training, reproducibility, and comparability of studies.
Pohlmann, A. and Back, S.J. and Fekete, A. and Friedli, I. and Hectors, S. and Jerome, N.P. and Ku, M.C. and Longo, D.L. and Meier, M. and Millward, J.M. and Periquito, J.S. and Seeliger, E. and Serai, S.D and Waiczies, S. and Sourbron, S. and Laustsen, C. and Niendorf, T.
Methods in Molecular Biology 2216 : 3-23. 2021

Essential practical steps for MRI of the kidney in experimental research.
Pohlmann, A. and Periquito, J.S. and Niendorf, T.
Methods in Molecular Biology 2216 : 349-367. 2021

Experimental protocol for MRI mapping of the blood oxygenation-sensitive parameters T(2)* and T(2) in the kidney.
Pohlmann, A. and Zhao, K. and Fain, S.B. and Prasad, P.V. and Niendorf, T.
Methods in Molecular Biology 2216 : 403-417. 2021

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy.
Prinz, C. and Starke, L. and Millward, J.M. and Fillmer, A. and Delgado, P.R. and Waiczies, H. and Pohlmann, A. and Rothe, M. and Nazaré, M. and Paul, F. and Niendorf, T. and Waiczies, S.
Theranostics 11 (6): 2490-2504. 1 January 2021

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C. and Starke, L. and Ramspoth, T.F. and Kerkering, J. and Martos Riaño, V. and Paul, J. and Neuenschwander, M. and Oder, A. and Radetzki, S. and Adelhoefer, S. and Ramos Delgado, P. and Aravina, M. and Millward, J.M. and Fillmer, A. and Paul, F. and Siffrin, V. and von Kries, J.P. and Niendorf, T. and Nazaré, M. and Waiczies, S.
ACS Sensors 6 (11): 3948–3956. 26 November 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 81 (8): 2116-2127. April 2021

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.
Rajasekaran, S. and Siddiqui, J. and Rakijas, J. and Nicolay, B. and Lin, C. and Khan, E. and Patel, R. and Morris, R. and Wyler, E. and Boukhali, M. and Balasubramanyam, J. and Ranjith Kumar, R. and Van Rechem, C. and Vogel, C. and Elchuri, S.V. and Landthaler, M. and Obermayer, B. and Haas, W. and Dyson, N. and Miles, W.
Communications Biology 4 (1): 977. 17 August 2021

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
iScience 24 (6): 102686. 25 June 2021

A universal peptide matrix interactomics approach to disclose motif dependent protein binding.
Ramberger, E. and Suarez-Artiles, L. and Perez-Hernandez, D. and Haji, M. and Popp, O. and Reimer, U. and Leutz, A. and Dittmar, G. and Mertins, P.
Molecular & Cellular Proteomics 20 : 100135. 13 August 2021

Subsegmentation of the kidney in experimental MR images using morphology-based regions-of-interest or multiple-layer concentric objects.
Riazy, L. and Milani, B. and Periquito, J.S. and Cantow, K. and Niendorf, T. and Pruijm, M. and Seeliger, E. and Pohlmann, A.
Methods in Molecular Biology 2216 : 549-564. 2021

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.
Rivera, M. and Fichtner, I. and Wulf-Goldenberg, A. and Sers, C. and Merk, J. and Patone, G. and Alp, K.M. and Kanashova, T. and Mertins, P. and Hoffmann, J. and Stein, U. and Walther, W.
Neoplasia 23 (1): 21-35. January 2021

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.
Rosswog, C. and Bartenhagen, C. and Welte, A. and Kahlert, Y. and Hemstedt, N. and Lorenz, W. and Cartolano, M. and Ackermann, S. and Perner, S. and Vogel, W. and Altmüller, J. and Nürnberg, P. and Hertwig, F. and Göhring, G. and Lilienweiss, E. and Stütz, A.M. and Korbel, J.O. and Thomas, R.K. and Peifer, M. and Fischer, M.
Nature Genetics 53 (12): 1673–1685. December 2021

RNA dynamics in Alzheimer’s disease.
Rybak-Wolf, A. and Plass, M.
Molecules 26 (17): 5113. 1 September 2021

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1.
Rybak-Wolf, A. and Wyler, E. and Legnini, I. and Loewa, A. and Glažar, P. and Kim, S.J. and Pentimalli, T.M. and Oliveras Martinez, A. and Beyersdorf, B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
bioRxiv : 2021.03.05.434122. 7 March 2021

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.
Schaufler, D. and Ast, D.F. and Tumbrink, H.L. and Abedpour, N. and Maas, L. and Schwäbe, A.E. and Spille, I. and Lennartz, S. and Fassunke, J. and Aldea, M. and Besse, B. and Planchard, D. and Nogova, L. and Michels, S. and Kobe, C. and Persigehl, T. and Westphal, T. and Koleczko, S. and Fischer, R. and Weber, J.P. and Altmüller, J. and Thomas, R.K. and Merkelbach-Bruse, S. and Gautschi, O. and Mezquita, L. and Büttner, R. and Wolf, J. and Peifer, M. and Brägelmann, J. and Scheffler, M. and Sos, M.L.
npj Precision Oncology 5 (1): 102. 17 December 2021

Small, seeding-competent huntingtin fibrils are prominent aggregate species in brains of zQ175 Huntington's disease knock-in mice.
Schindler, F. and Praedel, N. and Neuendorf, N. and Kunz, S. and Schnoegl, S. and Mason, M.A. and Taxy, B.A. and Bates, G.P. and Khoshnan, A. and Priller, J. and Grimm, J. and Maier, M. and Boeddrich, A. and Wanker, E.E.
Frontiers in Neuroscience 15 : 682172. 22 June 2021

Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons.
Schinke, C. and Fernandez Vallone, V. and Ivanov, A. and Peng, Y. and Körtvelyessy, P. and Nolte, L. and Huehnchen, P. and Beule, D. and Stachelscheid, H. and Boehmerle, W. and Endres, M.
Elsevier. October 2021

Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons.
Schinke, C. and Vallone, V.F. and Ivanov, A. and Peng, Y. and Körtvelyessy, P. and Nolte, L. and Huehnchen, P. and Beule, D. and Stachelscheid, H. and Boehmerle, W. and Endres, M.
Neurobiology of Disease 155 : 105391. July 2021

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance.
Schlautmann, L.P. and Boehm, V. and Lackmann, J.W. and Altmüller, J. and Dieterich, C. and Gehring, N.H.
bioRxiv : 2021.08.20.457088. 20 August 2021

mTOR-activating mutations in RRAGD are causative for kidney tubulopathy and cardiomyopathy.
Schlingmann, K.P. and Jouret, F. and Shen, K. and Nigam, A. and Arjona, F. and Dafinger, C. and Houillier, P. and Jones, D. and Kleinerüschkamp, F. and Oh, J. and Godefroid, N. and Eltan, M. and Güran, T. and Burtey, S. and Parotte, M.C. and König, J. and Braun, A. and Bos, C. and Serra, M.I. and Rehmann, H. and Zwartkruis, F. and Renkema, K. and Klingel, K. and Schulze-Bahr, E. and Schermer, B. and Bergmann, C. and Altmüller, J. and Thiele, H. and Beck, B. and Dahan, K. and Sabatini, D. and Liebau, M. and Vargas-Poussou, R. and Knoers, N. and Konrad, M. and de Baaij, J.
Journal of the American Society of Nephrology 32 (11): 2885-2899. 29 October 2021

Biallelic variants in YRDC cause a developmental disorder with progeroid features.
Schmidt, J. and Goergens, J. and Pochechueva, T. and Kotter, A. and Schwenzer, N. and Sitte, M. and Werner, G. and Altmueller, J. and Thiele, H. and Nürnberg, P. and Isensee, J. and Li, Y. and Müller, C. and Leube, B. and Reinhardt, H.C. and Hucho, T. and Salinas, G. and Helm, M. and Jachimowicz, R.D. and Wieczorek, D. and Kohl, T. and Lehnart, S.E. and Yigit, G. and Wollnik, B.
Human Genetics 140 (12): 1679-1693. December 2021

The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer's disease-like pathology by perturbing oligodendrocyte survival and neuronal homeostasis.
Schneeberger, S. and Kim, S.J. and Eede, P. and Boltengagen, A. and Braeuning, C. and Andreadou, M. and Becher, B. and Karaiskos, N. and Kocks, C. and Rajewsky, N. and Heppner, F.L.
bioRxiv : 2021.04.25.441313. 27 April 2021

Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia.
Schröder, S. and Li, Y. and Yigit, G. and Altmüller, J. and Bader, I. and Bevot, A. and Biskup, S. and Dreha-Kulaczewski, S. and Korenke, C.G. and Kottke, R. and Mayr, J.A. and Preisel, M. and Toelle, S.P. and Wente-Schulz, S. and Wortmann, S.B. and Hahn, H. and Boltshauser, E. and Uhmann, A. and Wollnik, B. and Brockmann, K.
Genetics in Medicine 23 (2): 341-351. February 2021

Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T. and Kedziora, S.M. and Haase, N. and Herse, F. and Alenina, N. and Müller, D.N. and Bader, M. and Schupp, M. and Dechend, R. and Golic, M. and Kräker, K.
Diabetologia 64 (12): 2829-2842. December 2021

Pathogenic variants associated with dilated cardiomyopathy predict outcome in pediatric myocarditis.
Seidel, F. and Holtgrewe, M. and Al-Wakeel-Marquard, N. and Opgen-Rhein, B. and Dartsch, J. and Herbst, C. and Beule, D. and Pickardt, T. and Klingel, K. and Messroghli, D. and Berger, F. and Schubert, S. and Kühnisch, J. and Klaassen, S.
Circulation Genomic and Precision Medicine 14 (4): e003250. 4 August 2021

Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge.
Sieberts, S.K. and Schaff, J. and Duda, M. and Pataki, B.Á. and Sun, M. and Snyder, P. and Daneault, J.F. and Parisi, F. and Costante, G. and Rubin, U. and Banda, P. and Chae, Y. and Chaibub Neto, E. and Dorsey, E.R. and Aydın, Z. and Chen, A. and Elo, L.L. and Espino, C. and Glaab, E. and Goan, E. and Golabchi, F.N. and Görmez, Y. and Jaakkola, M.K. and Jonnagaddala, J. and Klén, R. and Li, D. and McDaniel, C. and Perrin, D. and Perumal, T.M. and Rad, N.M. and Rainaldi, E. and Sapienza, S. and Schwab, P. and Shokhirev, N. and Venäläinen, M.S. and Vergara-Diaz, G. and Zhang, Y. and Wang, Y. and Guan, Y. and Brunner, D. and Bonato, P. and Mangravite, L.M. and Omberg, L.
NPJ Digital Medicine 4 (1): 53. 19 March 2021

New insights on Phyllanthus reticulatus Poir. leaves and stem bark extracts: UPLC-ESI-TOF-MS profiles, and biopharmaceutical and in silico analysis.
Sinan, K.I. and de la Luz Cádiz-Gurrea, M. and Javier Leyva-Jiménez, F. and Fernández-Ochoa, Á. and Segura-Carretero, A. and Glamocilja, J. and Sokovic, M. and Nenadić, M. and Aktumsek, A. and Dall'Acqua, S. and Zengin, G.
New Journal of Chemistry 45 (45): 21049-21065. 7 December 2021

Depletion of cardiac cardiolipin synthase alters systolic and diastolic function.
Smeir, E. and Leberer, S. and Blumrich, A. and Vogler, G. and Vasiliades, A. and Dresen, S. and Jaeger, C. and Gloaguen, Y. and Klose, C. and Beule, D. and Schulze, P.C. and Bodmer, R. and Foryst-Ludwig, A. and Kintscher, U.
iScience 24 (11): 103314. 19 November 2021

In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin’s lymphoma and facilitates ultrasensitive residual disease detection.
Sobesky, S. and Mammadova, L. and Cirillo, M. and Drees, E.E.E. and Mattlener, J. and Dörr, H. and Altmüller, J. and Shi, Z. and Bröckelmann, P.J. and Weiss, J. and Kreissl, S. and Sasse, S. and Ullrich, R.T. and Reinke, S. and Klapper, W. and Gerhard-Hartmann, E. and Rosenwald, A. and Roemer, M.G.M. and Nürnberg, P. and Hagenbeek, A. and Zijlstra, J.M. and Pegtel, D.M. and Engert, A. and Borchmann, P. and von Tresckow, B. and Borchmann, S.
Med 2 (10): 1171-1193. 8 October 2021

HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence.
Sofiadis, K. and Josipovic, N. and Nikolic, M. and Kargapolova, Y. and Übelmesser, N. and Varamogianni-Mamatsi, V. and Zirkel, A. and Papadionysiou, I. and Loughran, G. and Keane, J. and Michel, A. and Gusmao, E.G. and Becker, C. and Altmüller, J. and Georgomanolis, T. and Mizi, A. and Papantonis, A.
Molecular Systems Biology 17 (6): e9760. 1 June 2021

Ultrahigh field MRI determination of water diffusion rates in ex vivo human lenses of different age.
Stahnke, T. and Lindner, T. and Guthoff, R. and Stachs, O. and Wree, A. and Langner, S. and Niendorf, T. and Grabow, N. and Glass, Ä. and Beller, E. and Polei, S.
Quantitative Imaging in Medicine and Surgery 11 (7): 3029-3041. July 2021

Data preparation protocol for low signal-to-noise ratio fluorine-19 MRI.
Starke, L. and Niendorf, T. and Waiczies, S.
Methods in Molecular Biology 2216 : 711-722. 2021

Denoising for improved parametric MRI of the kidney: protocol for nonlocal means filtering.
Starke, L. and Tabelow, K. and Niendorf, T. and Pohlmann, A.
Methods in Molecular Biology 2216 : 565-576. 2021

Single-nuclei RNA-sequencing of plant tissues using a nanowell-based system.
Sunaga-Franze, D. and Muino, J.M. and Braeuning, C. and Xu, X. and Zong, M. and Smaczniak, C. and Yan, W. and Fischer, C. and Vidal, R. and Kliem, M. and Kaufmann, K. and Sauer, S.
Plant Journal 108 (3): 859-869. 5 November 2021

CALINCA - a novel pipeline for the identification of lncRNAs in podocyte disease.
Talyan, S. and Filipów, S. and Ignarski, M. and Smieszek, M. and Chen, H. and Kühne, L. and Butt, L. and Göbel, H. and Hoyer-Allo, K.J.R. and Koehler, F.C. and Altmüller, J. and Brinkkötter, P. and Schermer, B. and Benzing, T. and Kann, M. and Müller, R.U. and Dieterich, C.
Cells 10 (3): 692. March 2021

Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19.
Theobald, S.J. and Simonis, A. and Georgomanolis, T. and Kreer, C. and Zehner, M. and Eisfeld, H.S. and Albert, M.C. and Chhen, J. and Motameny, S. and Erger, F. and Fischer, J. and Malin, J.J. and Gräb, J. and Winter, S. and Pouikli, A. and David, F. and Böll, B. and Koehler, P. and Vanshylla, K. and Gruell, H. and Suárez, I. and Hallek, M. and Fätkenheuer, G. and Jung, N. and Cornely, O.A. and Lehmann, C. and Tessarz, P. and Altmüller, J. and Nürnberg, P. and Kashkar, H. and Klein, F. and Koch, M. and Rybniker, J.
EMBO Molecular Medicine 13 (8): e14150. 9 August 2021

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. and Bischoff, P. and Peidli, S. and Sieber, A. and Trinks, A. and Lüthen, M. and Obermayer, B. and Blanc, E. and Ruchiy, Y. and Sell, T. and Mamlouk, S. and Arsie, R. and Wei, T.T. and Klotz-Noack, K. and Schwarz, R.F. and Sawitzki, B. and Kamphues, C. and Beule, D. and Landthaler, M. and Sers, C. and Horst, D. and Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13 (10): e14123. 7 October 2021

Dual-view light-sheet imaging through a tilted glass interface using a deformable mirror.
Vladimirov, N. and Preusser, F. and Wisniewski, J. and Yaniv, Z. and Desai, R.A. and Woehler, A. and Preibisch, S.
Biomedical Optics Express 12 (4): 2186-2203. 1 April 2021

The traveling heads 2.0: multicenter reproducibility of quantitative imaging methods at 7 Tesla.
Voelker, M.N. and Kraff, O. and Goerke, S. and Laun, F.B. and Hanspach, J. and Pine, K.J. and Ehses, P. and Zaiss, M. and Liebert, A. and Straub, S. and Eckstein, K. and Robinson, S. and Nagel, A.N. and Stefanescu, M.R. and Wollrab, A. and Klix, S. and Felder, J. and Hock, M. and Bosch, D. and Weiskopf, N. and Speck, O. and Ladd, M.E. and Quick, H.H.
NeuroImage 232 : 117910. 15 May 2021

Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism.
Volk, A.E. and Hedergott, A. and Preising, M. and Rading, S. and Fricke, J. and Herkenrath, P. and Nürnberg, P. and Altmüller, J. and von Ameln, S. and Lorenz, B. and Neugebauer, A. and Karsak, M. and Kubisch, C.
Human Genetics 140 (8): 1157-1168. August 2021

Contribution of preclinical MRI to responsible animal research: living up to the 3R principle.
Wachsmuth, L. and Mensen, A. and Barca, C. and Wiart, M. and Tristão-Pereira, C. and Busato, A. and Waiczies, S. and Himmelreich, U. and Millward, J.M. and Reimann, H.M. and Jelescu, I. and Marzola, P. and Pradier, B. and Viola, A. and Faber, C.
Magnetic Resonance Materials in Physics Biology and Medicine 34 (4): 469-474. August 2021

Magnetic resonance imaging of multiple sclerosis at 7.0 Tesla.
Waiczies, S. and Els, A. and Kuchling, J. and Markenroth Bloch, K. and Pankowska, A. and Waiczies, H. and Herrmann, C. and Chien, C. and Finke, C. and Paul, F. and Niendorf, T.
Journal of Visualized Experiments (168): e62142. 19 February 2021

Functional imaging using fluorine ((19)F) MR methods: basic concepts.
Waiczies, S. and Prinz, C. and Starke, L. and Millward, J.M. and Delgado, P.R. and Rosenberg, J. and Nazaré, M. and Waiczies, H. and Pohlmann, A. and Niendorf, T.
Methods in Molecular Biology 2216 : 279-299. 2021

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A. and Houwaart, T. and Finzer, P. and Ehlkes, L. and Tyshaieva, A. and Damagnez, M. and Strelow, D. and Duplessis, A. and Nicolai, J. and Wienemann, T. and Tamayo, T. and Kohns Vasconcelos, M. and Hülse, L. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Däumer, M.P. and Thielen, A. and Kolbe-Busch, S. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74 (6): 1039-1046. 15 March 2021

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells.
Wallmeroth, D. and Boehm, V. and Lackmann, J.W. and Altmüller, J. and Dieterich, C. and Gehring, N.H.
bioRxiv : 2021.07.07.451444. 13 July 2021

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression.
Walter, S. and Franke, V. and Drayman, N. and Wyler, E. and Tay, S. and Landthaler, M. and Akalin, A. and Ensser, A. and Full, F.
bioRxiv : 2021.03.24.436599. 24 March 2021

Single cell transcriptome sequencing on the Nanopore platform with ScNapBar.
Wang, Q. and Boenigk, S. and Boehm, V. and Gehring, N.H. and Altmueller, J. and Dieterich, C.
RNA 27 (7): 763-770. July 2021

A homozygous AKNA frameshift variant is associated with microcephaly in a Pakistani family.
Waseem, S.S. and Moawia, A. and Budde, B. and Tariq, M. and Khan, A. and Ali, Z. and Khan, S. and Iqbal, M. and Malik, N.A. and Haque, S.U. and Altmüller, J. and Thiele, H. and Hussain, M.S. and Cirak, S. and Baig, S.M. and Nürnberg, P.
Genes 12 (10): 1494. October 2021

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
Epigenetics & Chromatin 14 (1): 8. 19 January 2021

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner, J. and Suwalski, P. and Holtgrewe, M. and Rakitko, A. and Thibeault, C. and Müller, M. and Patriki, D. and Quedenau, C. and Krüger, U. and Ilinsky, V. and Popov, I. and Balnis, J. and Jaitovich, A. and Helbig, E.T. and Lippert, L.J. and Stubbemann, P. and Real, L.M. and Macías, J. and Pineda, J.A. and Fernandez-Fuertes, M. and Wang, X. and Karadeniz, Z. and Saccomanno, J. and Doehn, J.M. and Hübner, R.H. and Hinzmann, B. and Salvo, M. and Blueher, A. and Siemann, S. and Jurisic, S. and Beer, J.H. and Rutishauser, J. and Wiggli, B. and Schmid, H. and Danninger, K. and Binder, R. and Corman, V.M. and Mühlemann, B. and Arjun Arkal, R. and Fragiadakis, G.K. and Mick, E. and Calfee, C.S. and Erle, D.J. and Hendrickson, C.M. and Kangelaris, K.N. and Krummel, M.F. and Woodruff, P.G. and Langelier, C.R. and Venkataramani, U. and García, F. and Zyla, J. and Drosten, C. and Braun, A. and Jones, T.C. and Suttorp, N. and Witzenrath, M. and Hippenstiel, S. and Zemojtel, T. and Skurk, C. and Wolfgang, P. and Borodina, T. and Ripke, S. and Sander, L.E. and Beule, D. and Landmesser, U. and Guettouche, T. and Kurth, F. and Heidecker, B.
EClinicalMedicine 40 : 101099. October 2021

De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.
Weng, P.L. and Majmundar, A.J. and Khan, K. and Lim, T.Y. and Shril, S. and Jin, G. and Musgrove, J. and Wang, M. and Ahram, D.F. and Aggarwal, V.S. and Bier, L.E. and Heinzen, E.L. and Onuchic-Whitford, A.C. and Mann, N. and Buerger, F. and Schneider, R. and Deutsch, K. and Kitzler, T.M. and Klämbt, V. and Kolb, A. and Mao, Y. and Moufawad El Achkar, C. and Mitrotti, A. and Martino, J. and Beck, B.B. and Altmüller, J. and Benz, M.R. and Yano, S. and Mikati, M.A. and Gunduz, T. and Cope, H. and Shashi, V. and Trachtman, H. and Bodria, M. and Caridi, G. and Pisani, I. and Fiaccadori, E. and AbuMaziad, A.S. and Martinez-Agosto, J.A. and Yadin, O. and Zuckerman, J. and Kim, A. and John-Kroegel, U. and Tyndall, A.V. and Parboosingh, J.S. and Innes, A.M. and Bierzynska, A. and Koziell, A.B. and Muorah, M. and Saleem, M.A. and Hoefele, J. and Riedhammer, K.M. and Gharavi, A.G. and Jobanputra, V. and Pierce-Hoffman, E. and Seaby, E.G. and O'Donnell-Luria, A. and Rehm, H.L. and Mane, S. and D'Agati, V.D. and Pollak, M.R. and Ghiggeri, G.M. and Lifton, R.P. and Goldstein, D.B. and Davis, E.E. and Hildebrandt, F. and Sanna-Cherchi, S.
American Journal of Human Genetics 108 (2): 357-367. 4 February 2021

The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Wilhelmi, Ilka and Grunwald, S. and Gimber, N. and Popp, O. and Dittmar, G. and Arumughan, A. and Wanker, E.E. and Laeger, T. and Schmoranzer, J. and Daumke, O. and Schümann, A.
Molecular Metabolism 45 : 101151. March 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D. and Benary, U. and Margineanu, A. and Vignola, M.L. and Konrath, F. and Pongrac, I.M. and Karimaddini, Z. and Vigilante, A. and Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Cell-type specialization in the brain is encoded by specific long-range chromatin topologies.
Winick-Ng, W. and Kukalev, A. and Harabula, I. and Zea Redondo, L. and Meijer, M. and Serebreni, L. and Bianco, S. and Szabo, D. and Chiariello, A.M. and Irastorza-Azcarate, I. and Fiorillo, L. and Musella, F. and Thieme, C. and Irani, E. and Torlai Triglia, E. and Kolodziejczyk, A.A. and Abentung, A. and Apostolova, G, and Paul, E.J. and Franke, V. and Kempfer, R. and Akalin, A. and Teichmann, S. and Dechant, G. and Ungless, M.A. and Nicodemi, M. and Castelo-Branco, G. and Pombo, A.
bioRxiv : 2020.04.02.020990. 12 May 2021

Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W. and Kukalev, A. and Harabula, I. and Zea-Redondo, L. and Szabó, D. and Meijer, M. and Serebreni, L. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Irastorza-Azcarate, I. and Thieme, C.J. and Sparks, T.M. and Carvalho, S. and Fiorillo, L. and Musella, F. and Irani, E. and Triglia, E.T. and Kolodziejczyk, A.A. and Abentung, A. and Apostolova, G. and Paul, E.J. and Franke, V. and Kempfer, R. and Akalin, A. and Teichmann, S.A. and Dechant, G. and Ungless, M.A. and Nicodemi, M. and Welch, L. and Castelo-Branco, G. and Pombo, A.
Nature 599 (7886): 684-691. 25 November 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsiè, R. and Klironomos, F. and Koppstein, D. and Hönzke, K. and Ayoub, S. and Buccitelli, C. and Hoffmann, K. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J. and Praktiknjo, S. and Meyer, T.F. and Müller, M.A. and Niemeyer, D. and Hocke, A. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
iScience 24 (3): 102151. 19 March 2021

Shared and oppositely regulated transcriptomic signatures in Huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective genes.
Yildirim, F. and Foddis, M. and Blumenau, S. and Müller, S. and Kajetan, B. and Holtgrewe, M. and Kola, V. and Beule, D. and Sassi, C.
Neurobiology of Aging 104 : 122.e1-122.e17. August 2021

Active perception during angiogenesis: filopodia speed up Notch selection of tip cells in silico and in vivo.
Zakirov, B. and Charalambous, G. and Thuret, R. and Aspalter, I.M. and Van-Vuuren, K. and Mead, T. and Harrington, K. and Regan, E.R. and Herbert, S.P. and Bentley, K.
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 376 (1821): 20190753. 29 March 2021

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Zhang, S. and Übelmesser, N. and Josipovic, N. and Forte, G. and Slotman, J.A. and Chiang, M. and Gothe, H.J. and Gusmao, E.G. and Becker, C. and Altmüller, J. and Houtsmuller, A.B. and Roukos, V. and Wendt, K.S. and Marenduzzo, D. and Papantonis, A.
Science Advances 7 (43): eabg8205. 22 October 2021

Physiological system analysis of the kidney by high-temporal-resolution T(2)* monitoring of an oxygenation step response.
Zhao, K. and Pohlmann, A. and Feng, Q. and Mei, Y. and Yang, G. and Yi, P. and Feng, Q. and Chen, W. and Zhou, L. and Wu, E.X. and Seeliger, E. and Niendorf, T. and Feng, Y.
Magnetic Resonance in Medicine 85 (1): 334-345. January 2021

2020

Computational genomics with R.
Akalin, A.
Chapman and Hall/CRC Computational Biology Series . CRC Press LLC, Milton. ISBN 9781498781855 2020

Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model.
Akpa, C.A. and Kleo, K. and Oker, E. and Tomaszewski, N. and Messerschmidt, C. and López, C. and Wagener, R. and Oehl-Huber, K. and Dettmer, K. and Schoeler, A. and Lenze, D. and Oefner, P.J. and Beule, D. and Siebert, R. and Capper, D. and Dimitrova, L. and Hummel, M.
BMC Cancer 20 (1): 427. 14 May 2020

DNA sonication inverse PCR for genome scale analysis of uncharacterized flanking sequences.
Alquezar‐Planas, D.E. and Löber, U. and Cui, P. and Quedenau, C. and Chen, W. and Greenwood, A.D.
Methods in Ecology and Evolution 22 September 2020

A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles.
Alsalim, R. and Lindemann, P. and López-Alberca, M.P. and Miksche, S. and Czechtizky, W. and Halland, N. and Nazaré, M.
Organic Letters 22 (18): 7393-7396. 18 September 2020

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC.
Appel, L.M. and Franke, V. and Bruno, M. and Grishkovskaya, I. and Kasiliauskaite, A. and Schoeberl, U.E. and Puchinger, M.G. and Kostrhon, S. and Beltzung, E. and Mechtler, K. and Lin, G. and Vlasova, A. and Leeb, M. and Pavri, R. and Stark, A. and Akalin, A. and Stefl, R. and Bernecky, C. and Djinovic-Carugo, K. and Slade, D.
bioRxiv : 2020.02.11.943159. 12 February 2020

Fasting alters the gut microbiome with sustained blood pressure and body weight reduction in metabolic syndrome patients.
Balogh, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
medRxiv : 2020.02.23.20027029. 25 February 2020

Consensus-based technical recommendations for clinical translation of renal BOLD MRI.
Bane, O. and Mendichovszky, I.A. and Milani, B. and Dekkers, I.A. and Deux, J.F. and Eckerbom, P. and Grenier, N. and Hall, M. and Inoue, T. and Laustsen, C. and Lerman, L. and Liu, C. and Morrell, G. and Pedersen, M. and Pruijm, M. and Sadowski, E. and Seeliger, E. and Sharma, K. and Thoeny, H. and Vermathen, P. and Wang, Z. and Serafin, Z. and Zhang, J. and Francis, S. and Sourbron, S. and Pohlmann, A. and Fain, S. and Prasad, P.
Magnetic Resonance Materials in Physics Biology and Medicine 33 : 199-215. February 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting Histone H2A-K15 ubiquitination.
Bashir, S. and Dang, T. and Rossius, J. and Wolf, J. and Kuehn, R.
BMC Biotechnology 20 (1): 57. 23 October 2020

Analysing central metabolism in ultra-high resolution: at the crossroads of carbon and nitrogen.
Bayram, S. and Fürst, S. and Forbes, M. and Kempa, S.
Molecular Metabolism 33 : 38-47. 19 March 2020

Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.
Becker, T. and Pich, A. and Tamm, S. and Hedtfeld, S. and Ibrahim, M. and Altmüller, J. and Dalibor, N. and Toliat, M.R. and Janciauskiene, S. and Tümmler, B. and Stanke, F.
Scientific Reports 10 (1): 22447. 31 December 2020

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Berndt, N. and Egners, A. and Mastrobuoni, G. and Vvedenskaya, O. and Fragoulis, A. and Dugourd, A. and Bulik, S. and Pietzke, M. and Bielow, C. and van Gassel, R. and Olde Damink, S.W. and Erdem, M. and Saez-Rodriguez, J. and Holzhütter, H.G. and Kempa, S. and Cramer, T.
British Journal of Cancer 122 (2): 233-244. 21 January 2020

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma.
Bischoff, P. and Trinks, A. and Obermayer, B. and Pett, J.P. and Lehmann, A. and Jurmeister, P. and Elsner, A. and Dziodzio, T. and Rückert, J.C. and Neudecker, J. and Falk, C. and Beule, D. and Sers, C. and Morkel, M. and Horst, D. and Blüthgen, N. and Klauschen, F.
bioRxiv : 2020.12.11.419606. 11 December 2020

Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease.
Blumenau, S. and Foddis, M. and Müller, S. and Holtgrewe, M. and Bentele, K. and Berchtold, D. and Beule, D. and Dirnagl, U. and Sassi, C.
Scientific Reports 10 (1): 7103. 28 April 2020

Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M. and Fischer, A. and Goetzke, C.C. and Neumaier, H.L. and Sauter, M. and Kespohl, M. and Müller, A.M. and Meckes, C. and Salbach, C. and Schenk, M. and Heuser, A. and Landmesser, U. and Weiner, J. and Meder, B. and Lehmann, L. and Kratzer, A. and Klingel, K. and Katus, H.A. and Kaya, Z. and Beling, A.
Circulation 141 (23): 1885-1902. 9 June 2020

Cardiorenal sodium MRI in small rodents using a quadrature birdcage volume resonator at 9.4 T.
Boehmert, L. and Waiczies, H. and Kuehne, A. and Oezerdem, C. and Waiczies, S. and Starke, L. and Ku, M.C. and Pohlmann, A. and Seeliger, E. and Niendorf, T.
Magnetic Resonance Materials in Physics Biology and Medicine 33 (1): 121-130. February 2020

An activatable lanthanide luminescent probe for time-gated detection of nitroreductase in live bacteria.
Brennecke, B. and Wang, Q. and Zhang, Q. and Hu, H.Y. and Nazaré, M.
Angewandte Chemie International Edition 59 (22): 8512-8516. 25 May 2020

Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, P. and Muñoz-Fuentes, V. and Murray, S.A. and Dickinson, M.E. and Bucan, M. and Nutter, L.M.J. and Peterson, K.A. and Haselimashhadi, H. and Flenniken, A.M. and Morgan, H. and Westerberg, H. and Konopka, T. and Hsu, C.W. and Christiansen, A. and Lanza, D.G. and Beaudet, A.L. and Heaney, J.D. and Fuchs, H. and Gailus-Durner, V. and Sorg, T. and Prochazka, J. and Novosadova, V. and Lelliott, C.J. and Wardle-Jones, H. and Wells, S. and Teboul, L. and Cater, H. and Stewart, M. and Hough, T. and Wurst, W. and Sedlacek, R. and Adams, D.J. and Seavitt, J.R. and Tocchini-Valentini, G. and Mammano, F. and Braun, R.E. and McKerlie, C. and Herault, Y. and de Angelis, M.H. and Mallon, A.M. and Lloyd, K.C.K. and Brown, S.D.M. and Parkinson, H. and Meehan, T.F. and Smedley, D.
Nature Communications 11 (1): 655. 31 January 2020

Imagine physiology without imaging.
Cantow, K. and Hummel, L. and Flemming, B. and Waiczies, S. and Niendorf, T. and Seeliger, E.
Acta Physiologica 230 (3): e13549. November 2020

Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils.
Cerofolini, L. and Ravera, E. and Bologna, S. and Wiglenda, T. and Böddrich, A. and Purfürst, B. and Benilova, I. and Korsak, M. and Gallo, G. and Rizzo, D. and Gonnelli, L. and Fragai, M. and De Strooper, B. and Wanker, E.E. and Luchinat, C.
Chemical Communications 56 (62): 8830-8833. 11 August 2020

Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing.
Conrad, T. and Ntini, E. and Lang, B. and Cozzuto, L. and Andersen, J.B. and Marquardt, J.U. and Ponomarenko, J. and Tartaglia, G.G. and Vang Orom, U.A.
RNA 26 (11): 1726-1730. November 2020

Maximizing transcription of nucleic acids with efficient T7 promoters.
Conrad, T. and Plumbom, I. and Alcobendas, M. and Vidal, R. and Sauer, S.
Communications Biology 3 (1): 439. 14 August 2020

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa, G. and Roeschert, I. and Prinz, F. and Baluapuri, A. and Silveira Vidal, R. and Schülein-Völk, C. and Chang, Y.C. and Ade, C.P. and Mastrobuoni, G. and Girard, C. and Kumar, A. and Wortmann, L. and Walz, S. and Lührmann, R. and Kempa, S. and Kuster, B. and Wolf, E. and Mumberg, D. and Eilers, M.
Molecular Cell 77 (6): 1322-1339. 19 March 2020

Revalorization of bioactive compounds from tropical fruit by-products and industrial applications by means of sustainable approaches.
Cádiz-Gurrea, M.L. and Villegas-Aguilar, M.C. and Leyva-Jiménez, F.J. and Pimentel-Moral, S. and Fernández-Ochoa, Á. and Alañón, M.E. and Segura-Carretero, A.
Food Research International 138 (Part B): 109786. December 2020

The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel, B. and Czimmerer, Z. and Halasz, L. and Boto, P. and Kolostyak, Z. and Poliska, S. and Berger, W.K. and Tzerpos, P. and Nagy, G. and Horvath, A. and Hajas, G. and Cseh, T. and Nagy, A. and Sauer, S. and Francois-Deleuze, J. and Szatmari, I. and Bacsi, A. and Nagy, L.
Genes & Development 34 (21-22): 1474-1492. 1 November 2020

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E.W. and Lebedin, M. and de la Rosa, K. and Kühn, R.
bioRxiv : 2020.05.11.088252. 12 May 2020

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Balasubramanian, S. and Sundaravinayagam, D. and Graf, R. and Rahjouei, A. and Driesner, M. and Keller, L. and Janz, M. and Akalin, A. and Di Virgilio, M.
bioRxiv : 2020.01.30.917062. 31 January 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP.
Dema, A. and Faust, D. and Lazarow, K. and Wippich, M. and Neuenschwander, M. and Zühlke, K. and Geelhaar, A. and Pallien, T. and Hallscheidt, E. and Eichhorst, J. and Wiesner, B. and Cernecká, H. and Popp, O. and Mertins, P. and Dittmar, G. and von Kries, J.P. and Klussmann, E.
Cells 9 (3): 673. 10 March 2020

RNA-sequencing and somatic mutation status of adrenocortical tumors: novel pathogenetic insights.
Di Dalmazi, G. and Altieri, B. and Scholz, C. and Sbiera, S. and Luconi, M. and Waldman, J. and Kastelan, D. and Ceccato, F. and Chiodini, I. and Arnaldi, G. and Riester, A. and Osswald, A. and Beuschlein, F. and Sauer, S. and Fassnacht, M. and Appenzeller, S. and Ronchi, C.L.
Journal of Clinical Endocrinology & Metabolism 105 (12): dgaa616. December 2020

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome.
Drivas, T.G. and Li, D. and Nair, D. and Alaimo, J.T. and Alders, M. and Altmüller, J. and Barakat, T.S. and Bebin, E.M. and Bertsch, N.L. and Blackburn, P.R. and Blesson, A. and Bouman, A.M. and Brockmann, K. and Brunelle, P. and Burmeister, M. and Cooper, G.M. and Denecke, J. and Dieux-Coëslier, A. and Dubbs, H. and Ferrer, A. and Gal, D. and Bartik, L.E. and Gunderson, L.B. and Hasadsri, L. and Jain, M. and Karimov, C. and Keena, B. and Klee, E.W. and Kloth, K. and Lace, B. and Macchiaiolo, M. and Marcadier, J.L. and Milunsky, J.M. and Napier, M.P. and Ortiz-Gonzalez, X.R. and Pichurin, P.N. and Pinner, J. and Powis, Z. and Prasad, C. and Radio, F.C. and Rasmussen, K.J. and Renaud, D.L. and Rush, E.T. and Saunders, C. and Selcen, D. and Seman, A.R. and Shinde, D.N. and Smith, E.D. and Smol, T. and Snijders Blok, L. and Stoler, J.M. and Tang, S. and Tartaglia, M. and Thompson, M.L. and van de Kamp, J.M. and Wang, J. and Weise, D. and Weiss, K. and Woitschach, R. and Wollnik, B. and Yan, H. and Zackai, E.H. and Zampino, G. and Campeau, P. and Bhoj, E.
European Journal of Human Genetics 28 (10): 1422-1431. October 2020

Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism.
Duscha, A. and Gisevius, B. and Hirschberg, S. and Yissachar, N. and Stangl, G.I. and Eilers, E. and Bader, V. and Haase, S. and Kaisler, J. and David, C. and Schneider, R. and Troisi, R. and Zent, D. and Hegelmaier, T. and Dokalis, N. and Gerstein, S. and Del Mare-Roumani, S. and Amidror, S. and Staszewski, O. and Poschmann, G. and Stühler, K. and Hirche, F. and Balogh, A. and Kempa, S. and Träger, P. and Zaiss, M.M. and Holm, J.B. and Massa, M.G. and Nielsen, H.B. and Faissner, A. and Lukas, C. and Gatermann, S.G. and Scholz, M. and Przuntek, H. and Prinz, M. and Forslund, S.K. and Winklhofer, K.F. and Müller, D.N. and Linker, R.A. and Gold, R. and Haghikia, A.
Cell 180 (6): 1067-1080. 19 March 2020

Brain iron and metabolic abnormalities in C19orf12 mutation carriers: a 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.
Dusek, P. and Mekle, R. and Skowronska, M. and Acosta-Cabronero, J. and Huelnhagen, T. and Robinson, S.D. and Schubert, F. and Deschauer, M. and Els, A. and Ittermann, B. and Schottmann, G. and Madai, V.I. and Paul, F. and Klopstock, T. and Kmiec, T. and Niendorf, T. and Wuerfel, J. and Schneider, S.A.
Movement Disorders 35 (1): 142-150. January 2020

Wideband self-grounded bow-tie antenna for thermal MR.
Eigentler, T.W. and Winter, L. and Han, H. and Oberacker, E. and Kuehne, A. and Waiczies, H. and Schmitter, S. and Boehmert, L. and Prinz, C. and Trefna, H.D. and Niendorf, T.
NMR in Biomedicine 33 (5): e4274. May 2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M. and Markó, L. and Schächterle, C. and Tsvetkov, D. and Cui, Y. and Maghsodi, S. and Bartolomaeus, T.U.P. and Maass, P.G. and Zühlke, K. and Gregersen, N. and Hübner, N. and Hodge, R. and Mühl, A. and Pohl, B. and Molé-Illas, R. and Geelhaar, A. and Walter, S. and Napieczynska, H. and Schelenz, S. and Taube, M. and Heuser, A. and Anistan, Y.M. and Qadri, F. and Todiras, M. and Plehm, R. and Popova, E. and Langanki, R. and Eichhorst, J. and Lehmann, M. and Wiesner, B. and Russwurm, M. and Forslund, S.K. and Kamer, I. and Müller, D.N. and Gollasch, M. and Aydin, A. and Bähring, S. and Bader, M. and Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Age attenuates the T-type Ca(V) 3.2-RyR axis in vascular smooth muscle.
Fan, G. and Kaßmann, M. and Cui, Y. and Matthaeus, C. and Kunz, S. and Zhong, C. and Zhu, S. and Xie, Yu and Tsvetkov, D. and Daumke, O. and Huang, Yu and Gollasch, M.
Aging Cell 19 (4): e13134. April 2020

Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M. and Fischer, C. and Urzi, A. and Vidal, R. and Kunz, S. and Ruffault, P.L. and Kabuss, L. and Hube, I. and Gazzerro, E. and Birchmeier, C. and Spuler, S. and Sauer, S. and Gouti, M.
Cell Stem Cell 26 (2): 172-186. 6 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J. and Marczenke, M. and Rudolph, I.M. and Nielsen, R. and Storm, T. and Ilsoe Christensen, E. and Diecke, S. and Emma, F. and Willnow, T.E.
Kidney International 98 (1): 159-167. July 2020

An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.
Foddis, M. and Winek, K. and Bentele, K. and Mueller, S. and Blumenau, S. and Reichhart N, N. and Crespo-Garcia, S. and Harnett, D. and Ivanov, A. and Meisel, A. and Joussen, A. and Strauss, O. and Beule, D. and Dirnagl, U. and Sassi, C.
Journal of Cerebral Blood Flow and Metabolism 40 (2): 276-287. 1 February 2020

Dissecting HSV-1-induced host shut-off at RNA level.
Friedel, C.C. and Whisnant, A.W. and Djakovic, L. and Rutkowski, A.J. and Friedl, M.S. and Kluge, M. and Williamson, J.C. and Sai, S. and Oliveira Vidal, R. and Sauer, S. and Hennig, T. and Prusty, B. and Lehner, P.J. and Matheson, N.J. and Erhard, F. and Dölken, L.
bioRxiv : 2020.05.20.106039. 20 May 2020

Progression-dependent altered metabolism in osteosarcoma resulting in different nutrient source dependencies.
Fritsche-Guenther, R. and Gloaguen, Y. and Kirchner, M. and Mertins, P. and Tunn, P.U. and Kirwan, J.A.
Cancers 12 (6): 1371. 27 May 2020

Parallel genetics of regulatory sequences in vivo.
Froehlich, J. and Uyar, B. and Herzog, M. and Theil, K. and Glažar, P. and Akalin, A. and Rajewsky, N.
bioRxiv : 2020.07.28.224998. 29 July 2020

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy.
García, H.D. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Pusch, F.F. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Schulte, J.H. and Haase, K. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
bioRxiv : 2020.12.04.411413. 2020

Prostaglandin E(2) in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8(+) T cells.
Gierlich, P. and Lex, V. and Technau, A. and Keupp, A. and Morper, L. and Glunz, A. and Sennholz, H. and Rachor, J. and Sauer, S. and Marcu, A. and Grigoleit, G.U. and Wölfl, M. and Schlegel, P.G. and Eyrich, M.
Cancer Immunology Immunotherapy 69 (6): 1029-1042. June 2020

Deep learning assisted peak curation for large scale LC-MS Metabolomics.
Gloaguen, Y. and Kirwan, J. and Beule, D.
bioRxiv : 2020.08.09.242727. 10 August 2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J. and Heuberger, J. and Vidal, R. and Goveas, N. and Kosel, F. and Berenguer-Llergo, A. and Kranz, A. and Wulf-Goldenberg, A. and Behrens, D. and Melcher, B. and Sauer, S. and Vieth, M. and Batlle, E. and Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue.
Grunwald, S.A. and Popp, O. and Haafke, S. and Jedraszczak, N. and Grieben, U. and Saar, K. and Patone, G. and Kress, W. and Steinhagen-Thiessen, E. and Dittmar, G. and Spuler, S.
Scientific Reports 10 : 2158. 7 February 2020

Design, implementation, evaluation and application of a 32-channel radio frequency signal generator for thermal magnetic resonance based anti-cancer treatment.
Han, H. and Eigentler, T.W. and Wang, S. and Kretov, E. and Winter, L. and Hoffmann, W. and Grass, E. and Niendorf, T.
Cancers 12 (7): 1720. 28 June 2020

Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U. and Kleinsorge, M. and Roos, L. and Yigit, G. and Li, Y. and Barbarics, B. and El-Battrawy, I. and Lan, H. and Tiburcy, M. and Hindmarsh, R. and Lenz, C. and Salinas, G. and Diecke, S. and Müller, C. and Adham, I. and Altmüller, J. and Nürnberg, P. and Paul, T. and Zimmermann, W.H. and Hasenfuss, G. and Wollnik, B. and Cyganek, L.
Circulation 142 (11): 1059-1076. 15 September 2020

Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B. and Alonso, G. and Georgana, I. and El-Jesr, M. and Martín, R. and Shair, K.H.Y. and Fischer, C. and Sauer, S. and Maluquer de Motes, C. and Alcamí, A.
Science Advances 6 (38): eabb4565. 18 September 2020

BRAVE-NET: fully automated arterial brain vessel segmentation in patients with cerebrovascular disease.
Hilbert, A. and Madai, V.I. and Akay, E.M. and Aydin, O.U. and Behland, J. and Sobesky, J. and Galinovic, I. and Khalil, A.A. and Taha, A.A. and Würfel, J. and Dusek, P. and Niendorf, T. and Fiebach, J.B. and Frey, D. and Livne, M.
medRxiv : 2020.04.08.20057570. 2020

BRAVE-NET: fully automated arterial brain vessel segmentation in patients with cerebrovascular disease.
Hilbert, A. and Madai, V.I. and Akay, E.M. and Aydin, O.U. and Behland, J. and Sobesky, J. and Galinovic, I. and Khalil, A.A. and Taha, A.A.A. and Wuerfel, J. and Dusek, P. and Niendorf, T. and Fiebach, J.B. and Frey, D. and Livne, M.
Frontiers in Artificial Intelligence 3 : 552258. 25 September 2020

Digestiflow: from BCL to FASTQ with ease.
Holtgrewe, M. and Messerschmidt, C. and Nieminen, M. and Beule, D.
Bioinformatics 36 (6): 1983-1985. 15 March 2020

VarFish: comprehensive DNA variant analysis for diagnostics and research.
Holtgrewe, M. and Stolpe, O. and Nieminen, M. and Mundlos, S. and Knaus, A. and Kornak, U. and Seelow, D. and Segebrecht, L. and Spielmann, M. and Fischer-Zirnsak, B. and Boschann, F. and Scholl, U. and Ehmke, N. and Beule, D.
Nucleic Acids Research 48 (W1): W162-W169. 2 July 2020

VarFish - Collaborative and comprehensive variant analysis for diagnosis and research.
Holtgrewe, M. and Stolpe, O. and Nieminen, M. and Mundlos, S. and Knaus, A. and Kornak, U. and Seelow, D. and Segebrecht, L. and Spielmann, M. and Fischer-Zirnsak, B. and Boschann, F. and Scholl, U. and Ehmke, N. and Beule, D.
bioRxiv : 2020.01.27.921965. 31 January 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma.
Hu, Y. and Pan, J. and Shah, P. and Ao, M. and Thomas, S.N. and Liu, Y. and Chen, L. and Schnaubelt, M. and Clark, D.J. and Rodriguez, H. and Boja, E.S. and Hiltke, T. and Kinsinger, C.R. and Rodland, K.D. and Li, Q.K. and Qian, J. and Zhang, Z. and Chan, D.W. and Zhang, H.
Cell Reports 33 (3): 108276. 20 October 2020

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
Ihantola, T. and Di Bucchianico, S. and Happo, M. and Ihalainen, M. and Uski, O. and Bauer, S. and Kuuspalo, K. and Sippula, O. and Tissari, J. and Oeder, S. and Hartikainen, A. and Rönkkö, T.J. and Martikainen, M.V. and Huttunen, K. and Vartiainen, P. and Suhonen, H. and Kortelainen, M. and Lamberg, H. and Leskinen, A. and Sklorz, M. and Michalke, B. and Dilger, M. and Weiss, C. and Dittmar, G. and Beckers, J. and Irmler, M. and Buters, J. and Candeias, J. and Czech, H. and Yli-Pirilä, P. and Abbaszade, G. and Jakobi, G. and Orasche, J. and Schnelle-Kreis, J. and Kanashova, T. and Karg, E. and Streibel, T. and Passig, J. and Hakkarainen, H. and Jokiniemi, J. and Zimmermann, R. and Hirvonen, M.R. and Jalava, P.I.
Particle and Fibre Toxicology 17 (1): 27. 15 June 2020

Controlled release of therapeutics from thermoresponsive nanogels: a thermal magnetic resonance feasibility study.
Ji, Y. and Winter, L. and Navarro, L. and Ku, M.C. and Periquito, J.S. and Pham, M. and Hoffmann, W. and Theune, L.E. and Calderón, M. and Niendorf, T.
Cancers 12 (6): 1380. 27 May 2020

Single cell RNA-sequencing-based analysis of CD4(+) T-cell subset-specific susceptibility to transcriptional modulation by HIV-1 latency-reversing agents.
Kazmierski, J. and Postmus, D. and Wyler, E. and Fischer, C. and Jansen, J. and Meixenberger, K. and Vitcetz, S.N. and Sohn, M. and Sauer, S. and Bannert, N. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.05.04.075119. 5 May 2020

CRISPLD1: a novel conserved target in the transition to human heart failure.
Khadjeh, S. and Hindmarsh, V. and Weber, F. and Cyganek, L. and Vidal, R.O. and Torkieh, S. and Streckfuss-Bömeke, K. and Lbik, D. and Tiburcy, M. and Mohamed, B.A. and Bonn, S. and Toischer, K. and Hasenfuss, G.
Basic Research in Cardiology 115 (3): 27. 7 March 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Lowenstein, E.D. and Schöwel, V. and Spuler, S. and Akalin, A. and Birchmeier, C.
Nature Communications 11 : 6375. 11 December 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Spuler, S. and Akalin, A. and Birchmeier, C.
bioRxiv : 2020.04.14.041665. 15 April 2020

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A. and van Rijssel, J. and Ramms, A.S. and Wild, R. and Hammer, J. and Merkel, M. and Derenbach, L. and Préau, L. and Hinkel, R. and Suarez-Martinez, I. and Schulte-Merker, S. and Vidal, R. and Sauer, S. and Kivelä, R. and Alitalo, K. and Kupatt, C. and van Buul, J.D. and le Noble, F.
Nature Communications 11 (1): 5319. 21 October 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

Regional expression profiles of risk genes for depression are associated with brain activation patterns in emotion and reward tasks.
Komorowski, A. and Vidal, R. and Singh, A. and Murgaš, M. and Pena-Centeno, T. and Gryglewski, G. and Kasper, S. and Wiltfang, J. and Lanzenberger, R. and Goya-Maldonado, R.
bioRxiv : 2020.06.27.175257. 27 June 2020

Deep learning for genomics using Janggu.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Vieira-Vieira, C.H. and Schaub, T. and Harnett, D. and Münster-Wandowski, A. and Bürger, J. and Zinnall, U. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Beule, D. and Landthaler, M. and Mielke, T. and Tarabykin, V. and Vida, I. and Selbach, M. and Spahn, C.M.T.
bioRxiv : 2020.02.08.939488. 10 February 2020

Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy.
Krug, K. and Jaehnig, E.J. and Satpathy, S. and Blumenberg, L. and Karpova, A. and Anurag, M. and Miles, G. and Mertins, P. and Geffen, Y. and Tang, L.C. and Heiman, D.I. and Cao, S. and Maruvka, Y.E. and Lei, J.T. and Huang, C. and Kothadia, R.B. and Colaprico, A. and Birger, C. and Wang, J. and Dou, Y. and Wen, B. and Shi, Z. and Liao, Y. and Wiznerowicz, M. and Wyczalkowski, M.A. and Chen, X.S. and Kennedy, J.J. and Paulovich, A.G. and Thiagarajan, M. and Kinsinger, C.R. and Hiltke, T. and Boja, E.S. and Mesri, M. and Robles, A.I. and Rodriguez, H. and Westbrook, T.F. and Ding, L. and Getz, G. and Clauser, K.R. and Fenyö, D. and Ruggles, K.V. and Zhang, B. and Mani, D.R and Carr, S.A. and Ellis, M.J. and Gillette, M.A.
Cell 183 (5): 1436-1456. 25 November 2020

Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes.
Kräker, K. and Herse, F. and Golic, M. and Reichhart, N. and Crespo-Garcia, S. and Straß, O. and Grune, J. and Kintscher, U. and Ebrahim, M. and Bader, M. and Alenina, N. and Heuser, A. and Luft, F.C. and Müller, D.N. and Dechend, R. and Haase, N.
Scientific Reports 10 (1): 14061. 20 August 2020

Solving the time- and frequency-multiplexed problem of constrained radiofrequency induced hyperthermia.
Kuehne, A. and Oberacker, E. and Waiczies, H. and Niendorf, T.
Cancers 12 (5): 1072. May 2020

TaxIt: an iterative computational pipeline for untargeted strain-level identification using MS/MS spectra from pathogenic single-organism samples.
Kuhring, M. and Doellinger, J. and Nitsche, A. and Muth, T. and Renard, B.Y.
Journal of Proteome Research 19 (6): 2501-2510. 5 June 2020

Concepts and software package for efficient quality control in targeted metabolomics studies - MeTaQuaC.
Kuhring, M. and Eisenberger, A. and Schmidt, V. and Kränkel, N. and Leistner, D.M. and Kirwan, J. and Beule, D.
Analytical Chemistry 92 (15): 10241-10245. 4 August 2020

Concepts and software package for efficient quality control in targeted metabolomics studies - MeTaQuaC.
Kuhring, M. and Eisenberger, A. and Schmidt, V. and Kränkel, N. and Leistner, D.M. and Kirwan, J. and Beule, D.
bioRxiv : 2020.01.10.901710. 11 January 2020

Support of a molecular tumour board by an evidence-based decision management system for precision oncology.
Lamping, M. and Benary, M. and Leyvraz, S. and Messerschmidt, C. and Blanc, E. and Kessler, T. and Schütte, M. and Lenze, D. and Jöhrens, K. and Burock, S. and Klinghammer, K. and Ochsenreither, S. and Sers, C. and Schäfer, R. and Tinhofer, I. and Beule, D. and Klauschen, F. and Yaspo, M.L. and Keilholz, U. and Rieke, D.T.
European Journal of Cancer 127 : 41-51. March 2020

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates.
Langer, H.T. and Afzal, S. and Kempa, S. and Spuler, S.
Scientific Reports 10 : 1908. 5 February 2020

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.
Lisewski, U. and Köhncke, C. and Schleussner, L. and Purfürst, B. and Lee, S.M. and De Silva, A. and Manville, R.W. and Abbott, G.W. and Roepke, T.K.
FASEB Journal 34 (8): 10699-10719. August 2020

Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.
Ljimani, A. and Caroli, A. and Laustsen, C. and Francis, S. and Mendichovszky, I.A. and Bane, O. and Nery, F. and Sharma, K. and Pohlmann, A. and Dekkers, I.A. and Vallee, J.P. and Derlin, K. and Notohamiprodjo, M. and Lim, R.P. and Palmucci, S. and Serai, S.D. and Periquito, J. and Wang, Z.J. and Froeling, M. and Thoeny, H.C. and Prasad, P. and Schneider, M. and Niendorf, T. and Pullens, P. and Sourbron, S. and Sigmund, E.E.
Magnetic Resonance Materials in Physics Biology and Medicine 33 (1): 177-195. February 2020

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling.
Lo, A. and Holmes, K. and Mundt, F. and Moorthi, S. and Fung, I. and Fereshetian, S. and Watson, J. and Carr, S.A. and Mertins, P. and Berger, A.H.
bioRxiv : 2020.04.10.030460. 11 April 2020

Enzymatic dissociation induces transcriptional and proteotype bias in brain cell populations.
Mattei, D. and Ivanov, A. and van Oostrum, M. and Pantelyushin, S. and Richetto, J. and Mueller, F. and Beffinger, M. and Schellhammer, L. and Vom Berg, J. and Wollscheid, B. and Beule, D. and Paolicelli, R.C. and Meyer, U.
International Journal of Molecular Sciences 21 (21): 7944. 1 November 2020

Enzymatic dissociation induces transcriptional and proteotype bias in brain cell populations.
Mattei, D. and Ivanov, A. and van Oostrum, M. and Pantelyushin, S. and Richetto, J. and Mueller, F. and Beffinger, M. M. and Schellhammer, L. and vom Berg, J. and Wollscheid, B. and Beule, D. and Paolicelli, R.C. and Meyer, U.
bioRxiv : 2020.05.14.095422. 16 May 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in wildtype and cloche/npas4l mutant zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Kempfer, R. and Mattonet, K. and Hirsekorn, A. and Bilić, I. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
bioRxiv : 2020.06.26.173377. 26 June 2020

Identification of novel disease relevant genetic modifiers affecting the SHH pathway in the developing brain.
Mecklenburg, N. and Kowalczyk, I. and Witte, F. and Görne, J. and Laier, A. and Gonschior, H. and Lehmann, M. and Richter, M. and Sporbert, A. and Purfürst, B. and Hübner, N. and Hammes, A.
bioRxiv : 2020.11.03.366302. 3 November 2020

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA.
Mendichovszky, I. and Pullens, P. and Dekkers, I. and Nery, F. and Bane, O. and Pohlmann, A. and de Boer, A. and Ljimani, A. and Odudu, A. and Buchanan, C. and Sharma, K. and Laustsen, C. and Harteveld, A. and Golay, X. and Pedrosa, I. and Alsop, D. and Fain, S. and Caroli, A. and Prasad, P. and Francis, S. and Sigmund, E. and Fernández-Seara, M. and Sourbron, S.
Magnetic Resonance Materials in Physics Biology and Medicine 33 : 131-140. February 2020

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu, E. and Lafzi, A. and Moutinho, C. and Ziegenhain, C. and McCarthy, D.J. and Álvarez-Varela, A. and Batlle, E. and Sagar, and Grün, D. and Lau, J.K. and Boutet, S.C. and Sanada, C. and Ooi, A. and Jones, R.C. and Kaihara, K. and Brampton, C. and Talaga, Y. and Sasagawa, Y. and Tanaka, K. and Hayashi, T. and Braeuning, C. and Fischer, C. and Sauer, S. and Trefzer, T. and Conrad, C. and Adiconis, X. and Nguyen, L.T. and Regev, A. and Levin, J.Z. and Parekh, S. and Janjic, A. and Wange, L.E. and Bagnoli, J.W. and Enard, W. and Gut, M. and Sandberg, R. and Nikaido, I. and Gut, I. and Stegle, O. and Heyn, H.
Nature Biotechnology 38 (6): 747-755. June 2020

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.
Messerschmidt, C. and Obermayer, B. and Klinghammer, K. and Ochsenreither, S. and Treue, D. and Stenzinger, A. and Glimm, H. and Fröhling, S. and Kindler, T. and Brandts, C.H. and Schulze-Osthoff, K. and Weichert, W. and Tinhofer, I. and Klauschen, F. and Keilholz, U. and Beule, D. and Rieke, D.T.
International Journal of Cancer 147 (8): 2293-2302. 15 October 2020

Generation of three age and gender matched pairs of human induced pluripotent stem cells derived from myoblasts (MDCi011-A, MDCi012-A, MDCi013-A) and from peripheral blood mononuclear cells (MDCi011-B, MDCi012-B, MDCi013-B) from the same donor.
Metzler, E. and Telugu, N. and Diecke, S. and Spuler, S. and Escobar, H.
Stem Cell Research 48 : 101987. October 2020

Generation of two human induced Pluripotent Stem Cell lines derived from myoblasts (MDCi014-A) and from peripheral blood mononuclear cells (MDCi014-B) from the same donor.
Metzler, E. and Telugu, N. and Diecke, S. and Spuler, S. and Escobar, H.
Stem Cell Research 48 : 101998. October 2020

HIV-1 Gag release from yeast reveals ESCRT interaction with the Gag N-terminal protein region.
Meusser, B. and Purfuerst, B. and Luft, F.C.
Journal of Biological Chemistry 295 (52): 17950-17972. 25 December 2020

Diverse chemotypes drive biased signaling by cannabinoid receptors.
Miljuš, T. and Heydenreich, F.M. and Gazzi, T. and Kimbara, A. and Rogers-Evans, M. and Nettekoven, M. and Zirwes, E. and Osterwald, A. and Rufer, A.C. and Ullmer, C. and Guba, W. and Le Gouill, C. and Fingerle, J. and Nazaré, M. and Grether, U. and Bouvier, M. and Veprintsev, D.B.
bioRxiv : 2020.11.09.375162. 10 November 2020

Simple workflow and comparison of media for hPSC-cardiomyocyte cryopreservation and recovery.
Miller, D.C. and Genehr, C. and Telugu, N.S. and Kurths, S. and Diecke, S.
Current Protocols in Stem Cell Biology 55 (1): e125. December 2020

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis.
Millward, J.M. and Delgado, P.R. and Smorodchenko, A. and Boehmert, L. and Periquito, J. and Reimann, H.M. and Prinz, C. and Els, A. and Scheel, M. and Bellmann-Strobl, J. and Waiczies, H. and Wuerfel, J. and Infante-Duarte, C. and Chien, C. and Kuchling, J. and Pohlmann, A. and Zipp, F. and Paul, F. and Niendorf, T. and Waiczies, S.
JCI Insight 5 (21): e140040. 5 November 2020

Analysis of driver mutational hot spots in blood-derived cell-free DNA of patients with primary central nervous system lymphoma obtained before intracerebral biopsy.
Montesinos-Rongen, M. and Brunn, A. and Tuchscherer, A. and Borchmann, P. and Schorb, E. and Kasenda, B. and Altmüller, J. and Illerhaus, G. and Ruge, M.I. and Maarouf, M. and Büttner, R. and Hansmann, M.L. and Hallek, M. and Prinz, M. and Siebert, R. and Deckert, M.
Journal of Molecular Diagnostics 22 (10): 1300-1307. October 2020

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y. and Heynen, G.J.J.E. and López-Alberca, M.P. and Paul, J. and Miksche, S. and Radetzki, S. and Schaller, D. and Shanina, E. and Seyffarth, C. and Kolomeets, Y. and Ziebart, N. and de Schryver, J. and Oestreich, S. and Neuenschwander, M. and Roske, Y. and Heinemann, U. and Rademacher, C. and Volkamer, A. and von Kries, J.P. and Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63 (23): 14780-14804. 10 December 2020

Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. and Isbilir, A. and Sungkaworn, T. and Osberg, B. and Karathanasis, C. and Sunkara, V. and Grushevskyi, E.O. and Bock, A. and Annibale, P. and Heilemann, M. and Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16 (9): 946-954. September 2020

ONX 0914 lacks selectivity for the cardiac immunoproteasome in CoxsackievirusB3 myocarditis of NMRI mice and promotes virus-mediated tissue damage.
Neumaier, H.L. and Harel, S. and Klingel, K. and Kaya, Z. and Heuser, A. and Kespohl, M. and Beling, A.
Cells 9 (5): 1093. May 2020

SODAR Core: a Django-based framework for scientific data management and analysis web apps.
Nieminen, M. and Stolpe, O. and Schumann, F. and Holtgrewe, M. and Beule, D.
Journal of Open Source Software 5 (55): 1584. 15 November 2020

Google maps for tissues: multiscale imaging of biological systems and disease.
Niendorf, T. and Frydman, L. and Neeman, M. and Seeliger, E.
Acta Physiologica 228 (2): e13392. February 2020

Probing renal blood volume with magnetic resonance imaging.
Niendorf, T. and Seeliger, E. and Cantow, K. and Flemming, B. and Waiczies, S. and Pohlmann, A.
Acta Physiologica 228 (4): e13435. April 2020

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Höfler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
bioRxiv : 2020.12.18.423524. 19 December 2020

Radiofrequency applicator concepts for thermal magnetic resonance of brain tumors at 297 MHz (7.0 Tesla).
Oberacker, E. and Kuehne, A. and Oezerdem, C. and Nadobny, J. and Weihrauch, M. and Beck, M. and Zschaeck, S. and Diesch, C. and Eigentler, T.W. and Waiczies, H. and Ghadjar, P. and Wust, P. and Winter, L. and Niendorf, T.
International Journal of Hyperthermia 37 (1): 549-563. 2 June 2020

Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
Oberbeck, S. and Schrader, A. and Warner, K. and Jungherz, D. and Crispatzu, G. and von Jan, J. and Chmielewski, M. and Ianevski, A. and Diebner, H.H. and Mayer, P. and Kondo Ados, A. and Wahnschaffe, L. and Braun, T. and Müller, T.A. and Wagle, P. and Bouska, A. and Neumann, T. and Pützer, S. and Varghese, L. and Pflug, N. and Thelen, M. and Makalowski, J. and Riet, N. and Göx, H.J.M and Rappl, G. and Altmüller, J. and Kotrová, M. and Persigehl, T. and Hopfinger, G. and Hansmann, M.L. and Schlößer, H. and Stilgenbauer, S. and Dürig, J. and Mougiakakos, D. and von Bergwelt-Baildon, M. and Roeder, I. and Hartmann, S. and Hallek, M. and Moriggl, R. and Brüggemann, M. and Aittokallio, T. and Iqbal, J. and Newrzela, S. and Abken, H. and Herling, M.
Blood 136 (24): 2786-2802. 10 December 2020

SCelVis: exploratory single cell data analysis on the desktop and in the cloud.
Obermayer, B. and Holtgrewe, M. and Nieminen, M. and Messerschmidt, C. and Beule, D.
PeerJ 8 : e8607. 19 February 2020

Towards a more reliable identification of isomeric metabolites using pattern guided retention validation.
Opialla, T. and Kempa, S. and Pietzke, M.
Metabolites 10 (11): 457. 12 November 2020

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial maturation.
Ostrop, J. and Zwiggelaar, R. and Pedersen, M.T. and Gerbe, F. and Bösl, K. and Lindholm, H.T. and Díez-Sánchez, Al. and Parmar, N. and Radetzki, S. and von Kries, J.P. and Jay, P. and Jensen, K.B. and Arrowsmith, C. and Oudhoff, M.J.
bioRxiv : 2020.07.23.217414. 24 July 2020

Pairwise stimulations of pathogen-sensing pathways predict immune responses to multi-adjuvant combinations.
Pandey, S. and Gruenbaum, A. and Kanashova, T. and Mertins, P. and Cluzel, P. and Chevrier, N.
Cell Systems 11 (5): 495-508. 18 November 2020

Pairwise interactions in adjuvant combinations dictate immune responses and inform cancer immunotherapy design.
Pandey, S. and Gruenbaum, A. and Kanashova, T. and Mertins, P. and Cluzel, P. and Chevrier, N.
bioRxiv : 2020.07.11.198879. 12 July 2020

Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding.
Pei, W. and Shang, F. and Wang, X. and Fanti, A.K. and Greco, A. and Busch, K. and Klapproth, K. and Zhang, Q. and Quedenau, C. and Sauer, S. and Feyerabend, T.B. and Höfer, T. and Rodewald, H.R.
Cell Stem Cell 27 (3): 383-395. 3 September 2020

Resolving fate and transcriptome of hematopoietic stem cell clones.
Pei, W. and Shang, F. and Wang, X. and Fanti, A.K. and Greco, A. and Busch, K. and Klapproth, K. and Zhang, Q. and Quedenau, C. and Sauer, S. and Feyerabend, T.B. and Höfer, T. and Rodewald, H.R.
bioRxiv : 2020.03.25.008433. 26 March 2020

Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction.
Peitz, C. and Sprüssel, A. and Linke, R.B. and Astrahantseff, K. and Grimaldi, M. and Schmelz, K. and Toedling, J. and Schulte, J.H. and Fischer, M. and Messerschmidt, C. and Beule, D. and Keilholz, U. and Eggert, A. and Deubzer, H.E. and Lodrini, M.
Journal of Molecular Diagnostics 22 (11): 1309-1323. November 2020

Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: a randomized clinical trial.
Pivovarova-Ramich, O. and Markova, M. and Weber, D. and Sucher, S. and Hornemann, S. and Rudovich, N. and Raila, J. and Sunaga-Franze, D. and Sauer, S. and Rohn, S. and Pfeiffer, A.F.H. and Grune, T.
Redox Biology 29 (2): 101397. January 2020

Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy.
Prahst, C. and Ashrafzadeh, P. and Mead, T. and Figueiredo, A. and Chang, K. and Richardson, D. and Venkaraman, L. and Richards, M. and Russo, A.M. and Harrington, K. and Ouarné, M. and Pena, A. and Chen, J.X. and Claesson-Welsh, L. and Cho, K.S. and Franco, C.A. and Bentley, K.
eLife 9 : e49779. 19 February 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Splicing-accessible coding 3'UTRs control protein stability and interaction networks.
Preussner, M. and Gao, Q. and Morrison, E. and Herdt, O. and Finkernagel, F. and Schumann, M. and Krause, E. and Freund, C. and Chen, W. and Heyd, F.
Genome Biology 21 (1): 186. 29 July 2020

Paroxysmal tonic upgaze: a heterogeneous clinical condition responsive to carbonic anhydrase inhibition.
Quade, A. and Thiel, A. and Kurth, I. and Holtgrewe, M. and Elbracht, M. and Beule, D. and Eggermann, K. and Scholl, U.I. and Häusler, M.
European Journal of Paediatric Neurology 25 : 181-186. March 2020

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer.
Quinn, H. and Koren, E. and Vogel, R. and Popp, O. and Mertins, P. and Messerschmidt, C. and Marangoni, E. and Fuchs, Y. and Birchmeier, W.
bioRxiv : 2020.06.05.115881. 6 June 2020

A comprehensive motifs-based interactome of the C/EBPα transcription factor.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
bioRxiv : 2020.12.28.424569. 28 December 2020

Functional annotation of human long noncoding RNAs via molecular phenotyping.
Ramilowski, J.A. and Yip, C.W. and Agrawal, S. and Chang, J.C. and Ciani, Y. and Kulakovskiy, I.V. and Mendez, M. and Ooi, J.L.C. and Ouyang, J.F. and Parkinson, N. and Petri, A. and Roos, L. and Severin, J. and Yasuzawa, K. and Abugessaisa, I. and Akalin, A. and Antonov, I.V. and Arner, E. and Bonetti, A. and Bono, H. and Borsari, B. and Brombacher, F. and Cameron, C.J.F. and Cannistraci, C.V. and Cardenas, R. and Cardon, M. and Chang, H. and Dostie, J. and Ducoli, L. and Favorov, A. and Fort, A. and Garrido, D. and Gil, N. and Gimenez, J. and Guler, R. and Handoko, L. and Harshbarger, J. and Hasegawa, A. and Hasegawa, Y. and Hashimoto, K. and Hayatsu, N. and Heutink, P. and Hirose, T. and Imada, E.L. and Itoh, M. and Kaczkowski, B. and Kanhere, A. and Kawabata, E. and Kawaji, H. and Kawashima, T. and Kelly, S.T. and Kojima, M. and Kondo, N. and Koseki, H. and Kouno, T. and Kratz, A. and Kurowska-Stolarska, M. and Kwon, A.T.J. and Leek, J. and Lennartsson, A. and Lizio, M. and López-Redondo, F. and Luginbühl, J. and Maeda, S. and Makeev, V.J. and Marchionni, L. and Medvedeva, Y.A. and Minoda, A. and Müller, F. and Muñoz-Aguirre, M. and Murata, M. and Nishiyori, H. and Nitta, K.R. and Noguchi, S. and Noro, Y. and Nurtdinov, R. and Okazaki, Y. and Orlando, V. and Paquette, D. and Parr, C.J.C. and Rackham, O.J.L. and Rizzu, P. and Sánchez Martinez, D.F. and Sandelin, A. and Sanjana, P. and Semple, C.A.M. and Shibayama, Y. and Sivaraman, D.M. and Suzuki, T. and Szumowski, S.C. and Tagami, M. and Taylor, M.S. and Terao, C. and Thodberg, M. and Thongjuea, S. and Tripathi, V. and Ulitsky, I. and Verardo, R. and Vorontsov, I.E. and Yamamoto, C. and Young, R.S. and Baillie, J.K. and Forrest, A.R.R. and Guigó, R. and Hoffman, M.M. and Hon, C.C. and Kasukawa, T. and Kauppinen, S. and Kere, J. and Lenhard, B. and Schneider, C. and Suzuki, H. and Yagi, K. and de Hoon, M.J.L. and Shin, J.W. and Carninci, P.
Genome Research 30 (7): 1060-1072. July 2020

B(1) inhomogeneity correction of RARE MRI with transceive surface radiofrequency probes.
Ramos Delgado, P. and Kuehne, A. and Periquito, J.S. and Millward, J.M. and Pohlmann, A. and Waiczies, S. and Niendorf, T.
Magnetic Resonance in Medicine 84 (5): 2684-2701. November 2020

The (un)conscious mouse as a model for human brain functions: key principles of anesthesia and their impact on translational neuroimaging.
Reimann, H.M. and Niendorf, T.
Frontiers in Systems Neuroscience 14 : 8. 19 May 2020

Phosphorylation of RAB7 by TBK1/IKKε regulates innate immune signaling in triple negative breast cancer.
Ritter, J.L. and Zhu, Z. and Thai, T.C. and Mahadevan, N.R. and Mertins, P. and Knelson, E.H. and Piel, B.P. and Han, S. and Jaffe, J.D. and Carr, S.A. and Barbie, D.A. and Barbie, T.U.
Cancer Research 80 (1): 44-56. January 2020

Diffusive dynamics and jamming in ensembles of robots with variable friction.
Rozenblit, A.D. and Porvatov, V.A. and Petrova, D.A. and Khakhalin, I.S. and Kotlyar, K.P. and Gritsenko, G.Y. and Evreiskaya, A.A. and Lebedeva, M.F. and Kretov, E.I. and Filonov, D.S. and Souslov, A. and Olekhno, N.A.
Journal of Physics: Conference Series 1695 (1): 012201. 28 December 2020

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F. and Fink, C. and Hüttemeister, J. and Kirchner, M. and Radke, M.H. and Lopez Carballo, J. and Wagner, E. and Kohl, T. and Lehnart, S.E. and Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Targeted proteomics reveals quantitative differences in low abundance glycosyltransferases of patients with Congenital Disorders of Glycosylation.
Sakson, R. and Beedgen, L. and Bernhard, P. and Alp, K.M. and Lübbehusen, N. and Röth, R. and Niesler, B. and Mayer, M.P. and Thiel, C. and Ruppert, T.
bioRxiv : 2020.09.15.291732. 16 September 2020

Intestinal expression of toll-like receptor gene changes early after gastric bypass surgery and association with type 2 diabetes remission.
Sala, P. and Torrinhas, R.S.M.M. and Fonseca, D.C. and Machado, N.M. and Singer, J. and Singer, P. and Ravacci, G.R. and Belarmino, G. and Ferreira, B.A.M. and Marques, M. and Ishida, R.K. and Guarda, I.F.M.S. and de Moura, E.G.H. and Sakai, P. and Santo, M.A. and Sunaga, D.Y. and Heymsfield, S.B. and Bezerra, D.P.D.S. and Corrêa-Giannella, M.L. and Waitzberg, D.L.
Nutrition 79-80 : 110885. November 2020

Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1).
Samir, M. and Vidal, R.O. and Abdallah, F. and Capece, V. and Seehusen, F. and Geffers, R. and Hussein, A. and Ali, A.A.H. and Bonn, S. and Pessler, F.
RNA Biology 17 (1): 112-124. January 2020

Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells.
Sarott, R.C. and Westphal, M. and Pfaff, P. and Korn, C. and Sykes, D.A. and Gazzi, T. and Brennecke, B. and Atz, K. and Weise, M. and Mostinski, Y. and Hompluem, P. and Koers, E. and Miljus, T. and Roth, N.J. and Asmelash, H. and Vong, M.C. and Piovesan, J. and Guba, W. and Rufer, A. and Kusznir, E.A. and Huber, S. and Raposo, C. and Zirwes, E.A. and Osterwald, A. and Pavlovic, A. and Moes, S. and Beck, J. and Benito-Cuesta, I. and Grande, T. and Ruiz de Martin, S. and Yeliseev, A.A. and Drawnel, F. and Widmer, G. and Holzer, D. and van der Wel, T. and Mandhair, H. and Yuan, C.Y. and Drobyski, W. and Saroz, Y. and Grimsey, N.L. and Honer, M. and Fingerle, J. and Gawrisch, K. and Romero, J. and Hillard, C. and Varga, Z. and van der Stelt, M. and Pacher, P. and Gertsch, J. and McCormick, P. and Ullmer, C. and Oddi, S. and Maccarrone, M. and Veprintsev, D. and Nazaré, M. and Grether, U. and Carreira, E.M.
Journal of the American Chemical Society 142 (40): 16953-16964. 7 October 2020

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J. and Mahnke, N.A. and Hofman, Z.L.M. and Maat, S.d. and Wu, J. and Bonnekoh, H. and Pengelly, R.J. and Ennis, S. and Holloway, J.W. and Kirchner, M. and Mertins, P. and Church, M.K. and Maurer, M. and Maas, C. and Krause, K.
Nature Communications 11 (1): 179. 10 January 2020

Portability of scientific workflows in NGS data analysis: a case study.
Schiefer, C. and Bux, M. and Brandt, J. and Messerschmidt, C. and Reinert, K. and Beule, D. and Leser, U.
arXiv : 2006.03104. 4 June 2020

B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS.
Schmidt, K. and Sack, U. and Graf, R. and Winkler, W. and Popp, O. and Mertins, P. and Sommermann, T. and Kocks, C. and Rajewsky, K.
Frontiers in Immunology 11 : 602868. 1 December 2020

Evidence of pathogenicity for the leaky splice variant c.1066-6T>G in ATM.
Schröder, S. and Wieland, B. and Ohlenbusch, A. and Yigit, G. and Altmüller, J. and Boltshauser, E. and Dörk, T. and Brockmann, K.
American Journal of Medical Genetics A 182 (12): 2971-2975. December 2020

Generation and characterization of a mitotane-resistant adrenocortical cell line.
Seidel, E. and Walenda, G. and Messerschmidt, C. and Obermayer, B. and Peitzsch, M. and Wallace, P. and Bahethi, R. and Yoo, T. and Choi, M. and Schrade, P. and Bachmann, S. and Liebisch, G. and Eisenhofer, G. and Beule, D. and Scholl, U.
Endocrine Connections 9 (2): 122-134. February 2020

Collagen organization within the cartilage of TRPV4(-/-) mice studied with two-photon microscopy and polarized second harmonic generation.
Servin-Vences, M.R. and Poole, K. and Sporbert, A. and Lewin, G.R. and Margineanu, A.
Cytometry Part A 97 (5): 504-514. May 2020

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T. and Yasuda, T. and Ronen, J. and Wirtz, T. and Weber, T. and Sack, U. and Caeser, R. and Zhang, J. and Li, X. and Chu, V.T. and Jauch, A. and Unger, K. and Hodson, D.J. and Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117 (25): 14421-14432. 23 June 2020

NMR quality control of fragment libraries for screening.
Sreeramulu, S. and Richter, C. and Kuehn, T. and Azzaoui, K. and Blommers, M.J.J. and Del Conte, R. and Fragai, M. and Trieloff, N. and Schmieder, P. and Nazaré, M. and Specker, E. and Ivanov, V. and Oschkinat, H. and Banci, L. and Schwalbe, H.
Journal of Biomolecular NMR 74 (10-11): 555-563. November 2020

Performance of compressed sensing for fluorine-19 magnetic resonance imaging at low signal-to-noise ratio conditions.
Starke, L. and Pohlmann, A. and Prinz, C. and Niendorf, T. and Waiczies, S.
Magnetic Resonance in Medicine 84 (2): 592-608. August 2020

Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts.
Stegbauer, J. and Kraus, M. and Nordmeyer, S. and Kirchner, M. and Ziehm, M. and Dommisch, H. and Kelle, S. and Kelm, M. and Baczko, I. and Landmesser, U. and Tschope, C. and Knosalla, C. and Falcke, M. and Schapranow, M.P. and Regitz-Zagrosek, V. and Mertins, P. and Kuehne, T.
Hypertension 76 (6): e41-e43. December 2020

Single-nuclei RNA-sequencing of plants.
Sunaga-Franze, D.Y. and Muino, J.M. and Braeuning, C. and Xu, X. and Zong, M. and Smaczniak, C. and Yan, W. and Fischer, C. and Vidal, R. and Kliem, M. and Kaufmann, K. and Sauer, S.
bioRxiv : 2020.11.14.382812. 16 November 2020

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
Swan, A.L. and Schütt, C. and Rozman, J. and Del Mar Muñiz Moreno, M. and Brandmaier, S. and Simon, M. and Leuchtenberger, S. and Griffiths, M. and Brommage, R. and Keskivali-Bond, P. and Grallert, H. and Werner, T. and Teperino, R. and Becker, L. and Miller, G. and Moshiri, A. and Seavitt, J.R. and Cissell, D.D. and Meehan, T.F. and Acar, E.F. and Lelliott, C.J. and Flenniken, A.M. and Champy, M.F. and Sorg, T. and Ayadi, A. and Braun, R.E. and Cater, H. and Dickinson, M.E. and Flicek, P. and Gallegos, J. and Ghirardello, E.J. and Heaney, J.D. and Jacquot, S. and Lally, C. and Logan, J.G. and Teboul, L. and Mason, J. and Spielmann, N. and McKerlie, C. and Murray, S.A. and Nutter, L.M.J. and Odfalk, K.F. and Parkinson, H. and Prochazka, J. and Reynolds, C.L. and Selloum, M. and Spoutil, F. and Svenson, K.L. and Vales, T.S. and Wells, S.E. and White, J.K. and Sedlacek, R. and Wurst, W. and Lloyd, K.K.C. and Croucher, P.I. and Fuchs, H. and Williams, G.R. and Bassett, D. and Gailus-Durner, V. and Herault, Y. and Mallon, A.M. and Brown, S.D.M. and Mayer-Kuckuk, P. and Hrabe de Angelis, M.
PLoS Genetics 16 (12): e1009190. 28 December 2020

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M. and Toedling, J. and Sprüssel, A. and Pfeil, S. and Savelyeva, L. and Capper, D. and Messerschmidt, C. and Beule, D. and Groeneveld-Krentz, S. and Eckert, C. and Gambara, G. and Henssen, A.G. and Finkler, S. and Schulte, J.H. and Sieber, A. and Bluethgen, N. and Regenbrecht, C.R.A. and Künkele, A. and Lodrini, M. and Eggert, A. and Deubzer, H.E.
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T. and Graf, R. and Wulf-Goldenberg, A. and Stecklum, M. and Strauß, G. and Kühn, R. and Kocks, C. and Rajewsky, K. and Chu, V.T.
Molecular Therapy 28 (12): 2621-2634. 2 December 2020

Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D. and Mani, D.C. and Satpathy, S. and Fereshetian, S. and Gasser, J.A. and Svinkina, T. and Olive, M.E. and Ebert, B.L. and Mertins, P. and Carr, S.A.
Nature Communications 11 (1): 359. 17 January 2020

De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome.
Ufartes, R. and Berger, H. and Till, K. and Salinas, G. and Sturm, M. and Altmüller, J. and Nürnberg, P. and Thiele, H. and Funke, R. and Apeshiotis, N. and Langen, H. and Wollnik, B. and Borchers, A. and Pauli, S.
Human Genetics 139 (11): 1363-1379. November 2020

A census of cell types and paracrine interactions in colorectal cancer.
Uhlitz, F. and Bischoff, P. and Sieber, A. and Obermayer, B. and Blanc, E. and Lüthen, M. and Sawitzki, B. and Kamphues, C. and Beule, D. and Sers, C. and Horst, D. and Blüthgen, N. and Morkel, M.
bioRxiv : 2020.01.10.901579. 11 January 2020

Single-cell analyses of aging, inflammation and senescence.
Uyar, B. and Palmer, D. and Kowald, A. and Escobar, H.M. and Barrantes, I. and Möller, S. and Akalin, A. and Fuellen, G.
Ageing Research Reviews 64 : 101156. December 2020

Methods for automated single cell isolation and sub-cloning of human pluripotent stem cells.
Vallone, V.F. and Telugu, N.S. and Fischer, I. and Miller, D. and Schommer, S. and Diecke, S. and Stachelscheid, H.
Current Protocols in Stem Cell Biology 55 (1): e123. December 2020

The association between salt taste perception, mediterranean diet and metabolic syndrome: a cross-sectional study.
Veček, N.N. and Mucalo, L. and Dragun, R. and Miličević, T. and Pribisalić, A. and Patarčić, I. and Hayward, C. and Polašek, O. and Kolčić, I.
Nutrients 12 (4): 1164. April 2020

Dual-view light-sheet imaging through tilted glass interface using a deformable mirror.
Vladimirov, N. and Preusser, F. and Wisniewski, J. and Yaniv, Z. and Desai, R.A. and Woehler, A. and Preibisch, S.
bioRxiv : 2020.10.20.345306. 21 October 2020

Preclinical lead optimization of a 1,2,4-triazole based tankyrase inhibitor.
Waaler, J. and Leenders, R. and Sowa, S.T. and Alam Brinch, S. and Lycke, M. and Nieczypor, P. and Aertssen, S. and Murthy, S. and Galera-Prat, A. and Damen, E. and Wegert, A. and Nazare, M. and Lehtiö, L. and Krauss, S.
Journal of Medicinal Chemistry 63 (13): 6834-6846. 9 July 2020

Mutations in SREBF1, encoding sterol regulatory element binding transcription factor 1, cause autosomal-dominant IFAP syndrome.
Wang, H. and Humbatova, A. and Liu, Y. and Qin, W. and Lee, M. and Cesarato, N. and Kortüm, F. and Kumar, S. and Romano, M.T. and Dai, S. and Mo, R. and Sivalingam, S. and Motameny, S. and Wu, Y. and Wang, X. and Niu, X. and Geng, S. and Bornholdt, D. and Kroisel, P.M. and Tadini, G. and Walter, S.D. and Hauck, F. and Girisha, K.M. and Calza, A.M. and Bottani, A. and Altmüller, J. and Buness, A. and Yang, S. and Sun, X. and Ma, L. and Kutsche, K. and Grzeschik, K.H. and Betz, R.C. and Lin, Z.
American Journal of Human Genetics 107 (1): 34-45. 2 July 2020

MR elastography-based assessment of matrix remodeling at lesion sites associated with clinical severity in a model of multiple sclerosis.
Wang, S. and Millward, J.M. and Hanke-Vela, L. and Malla, B. and Pilch, K. and Gil-Infante, A. and Waiczies, S. and Mueller, S. and Boehm-Sturm, P. and Guo, J. and Sack, I. and Infante-Duarte, C.
Frontiers in Neurology 10 : 1382. 13 January 2020

Comparative analysis of the secretome and interactome of Trypanosoma cruzi and Trypanosoma rangeli reveals species specific immune response modulating proteins.
Watanabe Costa, R. and Batista, M.F. and Meneghelli, I. and Vidal, R.O. and Nájera, C.A. and Mendes, A.C. and Andrade-Lima, I.A. and da Silveira, J.F. and Lopes, L.R. and Ferreira, L.R.P. and Antoneli, F. and Bahia, D.
Frontiers in Immunology 11 : 1774. 27 August 2020

Revealing cytotoxic substructures in molecules using deep learning.
Webel, H.E. and Kimber, T.B. and Radetzki, S. and Neuenschwander, M. and Nazaré, M. and Volkamer, A.
Journal of Computer-Aided Molecular Design 34 (7): 731-746. July 2020

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S. and Gimber, N. and Deuschel, D. and Stuhlmann, T. and Puchkov, D. and Farsi, Z. and Ludwig, C.F. and Novarino, G. and López-Cayuqueo, K.I. and Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39 (9): e103358. 4 May 2020

In vivo potassium MRI of the human heart.
Wenz, D. and Nagel, A.M. and Lott, J. and Kuehne, A. and Niesporek, S.C. and Niendorf, T.
Magnetic Resonance in Medicine 83 (1): 203-213. January 2020

IFT88 transports Gucy2d, a guanylyl cyclase, to maintain sensory cilia function in Drosophila.
Werner, S. and Zitouni, S. and Okenve-Ramos, P. and Mendonça, S. and Sporbert, A. and Spalthoff, C. and Göpfert, M.C. and Jana, S.C. and Bettencourt-Dias, M.
bioRxiv : 2020.12.15.417840. 15 December 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Sclerotiorin stabilizes the assembly of nonfibrillar Abeta42 oligomers with low toxicity, seeding activity, and beta-sheet content.
Wiglenda, T. and Groenke, N. and Hoffmann, W. and Manz, C. and Diez, L. and Buntru, A. and Brusendorf, L. and Neuendorf, N. and Schnoegl, S. and Haenig, C. and Schmieder, P. and Pagel, K. and Wanker, E.E.
Journal of Molecular Biology 432 (7): 2080-2098. 27 March 2020

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system.
Willnow, D. and Benary, U. and Margineanu, A. and Vignola, M.L. and Pongrac, I.M. and Karimaddini, Z. and Vigilante, A. and Wolf, J. and Spagnoli, F.M.
bioRxiv : 2020.08.06.240176. 6 August 2020

Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D. and Ameen, M. and Guo, H. and Abilez, O.J. and Tian, L. and Mumbach, M.R. and Diecke, S. and Qin, X. and Liu, Y. and Yang, H. and Ma, N. and Gaddam, S. and Cunningham, N.J. and Gu, M. and Neofytou, E. and Prado, M. and Hildebrandt, T.B. and Karakikes, I. and Chang, H.Y. and Wu, J.C.
Developmental Cell 54 (6): 694-709. 28 September 2020

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsie, R. and Klironomos, F. and Koppstein, D. and Ayoub, S. and Buccitelli, C. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J.P. and Müller, M.A. and Niemeyer, D. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
bioRxiv : 2020.05.05.079194. 5 May 2020

Dual-mode detection of bacterial 16S ribosomal RNA in tissues.
Xu, S. and Zhang, Q. and Han, X. and Wang, Y. and Wang, X. and Nazaré, M. and Jiang, J.D. and Hu, H.Y.
ACS Sensors 5 (6): 1650-1656. 26 June 2020

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.
Yusenko, M.V. and Trentmann, A. and Andersson, M.K. and Ghani, L.A. and Jakobs, A. and Arteaga Paz, M.F. and Mikesch, J.H. and von Kries, J.P. and Stenman, G. and Klempnauer, K.H.
Cancer Letters 479 : 61-70. 1 June 2020

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier.
Zerath Gurevich, S. and Sinha, A. and Longworth, J. and Singh, R.K. and Lemma, B.E. and Thakur, A. and Popp, O. and Kornitzer, D. and Reis, N. and Scheffner, M. and Dittmar, G. and Pick, E. and Fushman, D. and Glickman, M.H.
bioRxiv : 2020.06.18.159145. 19 June 2020

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A. and Conrad, J. and Telugu, N.S. and Diecke, S. and Heinz, A. and Wanker, E. and Priller, J. and Prigione, A.
Frontiers in Cell and Developmental Biology 8 : 590540. 5 November 2020

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A. and Conrad, J. and Telugu, N.S. and Diecke, S. and Heinz, A. and Wanker, E.E. and Priller, J. and Prigione, A.
bioRxiv : 2020.08.12.237461. 12 August 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Sanchez-Bailon, M.P. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Popp, O. and Mertins, P. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
Cell Reports 33 (13): 108533. 29 December 2020

2019

Regulation of influenza a virus mRNA splicing by CLK1.
Artarini, A. and Meyer, M. and Shin, Y.J. and Huber, K. and Hilz, N. and Bracher, F. and Eros, D. and Orfi, L. and Keri, G. and Goedert, S. and Neuenschwander, M. and von Kries, J. and Domovich-Eisenberg, Y. and Dekel, N. and Szabadkai, I. and Lebendiker, M. and Horváth, Z. and Danieli, T. and Livnah, O. and Moncorgé, O. and Frise, R. and Barclay, W. and Meyer, T.F. and Karlas, A.
Antiviral Research 168 : 187-196. August 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H. and Balogh, A. and Yakoub, M. and Homann, S. and Markó, L. and Höges, S. and Tsvetkov, D. and Krannich, A. and Wundersitz, S. and Avery, E.G. and Haase, N. and Kräker, K. and Hering, L. and Maase, M. and Kusche-Vihrog, K. and Grandoch, M. and Fielitz, J. and Kempa, S. and Gollasch, M. and Zhumadilov, Z. and Kozhakhmetov, S. and Kushugulova, A. and Eckardt, K.U. and Dechend, R. and Rump, L.C. and Forslund, S.K. and Müller, D.N. and Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

Tight junction proteins at the blood-brain barrier: far more than claudin-5.
Berndt, P. and Winkler, L. and Cording, J. and Breitkreuz-Korff, O. and Rex, A. and Dithmer, S. and Rausch, V. and Blasig, R. and Richter, M. and Sporbert, A. and Wolburg, H. and Blasig, I.E. and Haseloff, R.F.
Cellular and Molecular Life Sciences 76 (10): 1987-2002. May 2019

A resource of targeted mutant mouse lines for 5,061 genes.
Birling, M.C. and Yoshiki, A. and Adams, D.J. and Ayabe, S. and Beaudet, A.L. and Bottomley, J. and Bradley, A. and Brown, S.D.M. and Bürger, A. and Bushell, W. and Chiani, F. and Chin, H.J.G. and Christou, S. and Codner, G.F. and DeMayo, F.J. and Dickinson, M.E. and Doe, B. and Donahue, L.R. and Fray, M.D. and Gambadoro, A. and Gao, X. and Gertsenstein, M. and Gomez-Segura, A. and Goodwin, L.O. and Heaney, J.D. and Hérault, Y. and de Angelis, M.H. and Jiang, S.T. and Justice, M.J. and Kasparek, P. and King, R.E. and Kühn, R. and Lee, H. and Lee, Y.J. and Liu, Z. and Kent Lloyd, K.C. and Lorenzo, I. and Mallon, A.M. and McKerlie, C. and Meehan, T.F. and Newman, S. and Nutter, L.M.J. and Oh, G.T. and Pavlovic, G. and Ramirez-Solis, R. and Rosen, B. and Ryder, E.J. and Santos, L.A. and Schick, J. and Seavitt, J.R. and Sedlacek, R. and Seisenberger, C. and Seong, J.K. and Skarnes, W.C. and Sorg, T. and Steel, K.P. and Tamura, M. and Tocchini-Valentini, G.P. and Leo Wang, C.K. and Wardle-Jones, Ha. and Wattenhofer-Donzé, M. and Wells, S. and Willis, B.J. and Wood, J.A. and Wurst, W. and Xu, Y. and Teboul, L. and Murray, S.A.
bioRxiv : 844092. 22 November 2019

Identification and ranking of recurrent neo-epitopes in cancer.
Blanc, E. and Holtgrewe, M. and Dhamodaran, A. and Messerschmidt, C. and Willimsky, G. and Blankenstein, T. and Beule, D.
BMC Medical Genomics 12 : 171. 27 November 2019

Identification and regulation of the long non-coding RNA Heat2 in heart failure.
Boeckel, J.N. and Perret, M.F. and Glaser, S.F. and Seeger, T. and Heumüller, A.W. and Chen, W. and John, D. and Kokot, K.E. and Katus, H.A. and Haas, J. and Lackner, M.K. and Kayvanpour, E. and Grabe, N. and Dieterich, C. and von Haehling, S. and Ebner, N. and Hünecke, S. and Leuschner, F. and Fichtlscherer, S. and Meder, B. and Zeiher, A.M. and Dimmeler, S. and Keller, T.
Journal of Molecular and Cellular Cardiology 126 : 13-22. January 2019

The anti-amyloid compound DO1 decreases plaque pathology and neuroinflammation-related expression changes in 5xFAD transgenic mice.
Boeddrich, A. and Babila, J.T. and Wiglenda, T. and Diez, L. and Jacob, M. and Nietfeld, W. and Huska, M.R. and Haenig, C. and Groenke, N. and Buntru, A. and Blanc, E. and Meier, J.C. and Vannoni, E. and Erck, C. and Friedrich, B. and Martens, H. and Neuendorf, N. and Schnoegl, S. and Wolfer, D.P. and Loos, M. and Beule, D. and Andrade-Navarro, M.A. and Wanker, E.E.
Cell Chemical Biology 26 (1): 109-120. 17 January 2019

Cardiorenal sodium MRI at 7.0 Tesla using a 4/4 channel (1)H/(23)Na radiofrequency antenna array.
Boehmert, L. and Kuehne, A. and Waiczies, H. and Wenz, D. and Eigentler, T.W. and Funk, S. and von Knobelsdorff-Brenkenhoff, F. and Schulz-Menger, J. and Nagel, A.M. and Seeliger, E. and Niendorf, T.
Magnetic Resonance in Medicine 82 (6): 2343-2356. December 2019

WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
Borgsmüller, N. and Gloaguen, Y. and Opialla, T. and Blanc, E. and Sicard, E. and Royer, A.L. and Le Bizec, B. and Durand, S. and Migné, C. and Pétéra, M. and Pujos-Guillot, E. and Giacomoni, F. and Guitton, Y. and Beule, D. and Kirwan, J.
Metabolites 9 (9): 171. 21 August 2019

WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
Borgsmüller, N. and Gloaguen, Y. and Opialla, T. and Blanc, E. and Sicard, E. and Royer, A.L. and Le Bizec, B. and Durand, S. and Migné, C. and Pétéra, M. and Pujos-Guillot, E. and Giacomoni, F. and Guitton, Y. and Beule, D. and Kirwan, J.
bioRxiv : 713925. 24 July 2019

EU-OPENSCREEN: a novel collaborative approach to facilitate chemical biology.
Brennecke, P. and Rasina, D. and Aubi, O. and Herzog, K. and Landskron, J. and Cautain, B. and Vicente, F. and Quintana, J. and Mestres, J. and Stechmann, B. and Ellinger, B. and Brea, J. and Kolanowski, J.L. and Pilarski, R. and Orzaez, M. and Pineda-Lucena, A. and Laraia, L. and Nami, F. and Zielenkiewicz, P. and Paruch, K. and Hansen, E. and von Kries, J.P. and Neuenschwander, M. and Specker, E. and Bartunek, P. and Simova, S. and Leśnikowski, Z. and Krauss, S. and Lehtiö, L. and Bilitewski, U. and Brönstrup, M. and Taskén, K. and Jirgensons, A. and Lickert, H. and Clausen, M.H. and Andersen, J.H. and Vicent, M.J. and Genilloud, O. and Martinez, A. and Nazaré, M. and Fecke, W. and Gribbon, P.
SLAS Discovery 24 (3): 398-413. 1 March 2019

let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7.
Buonfiglioli, A. and Efe, I.E. and Guneykaya, D. and Ivanov, A. and Huang, Y. and Orlowski, E. and Krüger, C. and Deisz, R.A. and Markovic, D. and Flüh, C. and Newman, A.G. and Schneider, U.C. and Beule, D. and Wolf, S.A. and Dzaye, O. and Gutmann, D.H. and Semtner, M. and Kettenmann, H. and Lehnardt, S.
Cell Reports 29 (11): 3460-3471. 10 December 2019

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.
Chaimowicz, C. and Ruffault, P.L. and Chéret, C. and Woehler, A. and Zampieri, N. and Fortin, G. and Garratt, A.N. and Birchmeier, C.
Development 146 (17): dev174045. 6 September 2019

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing.
Chen, T. and Zhang, B. and Ziegenhals, T. and Prusty, A.B. and Fröhler, S. and Grimm, C. and Hu, Y. and Schaefke, B. and Fang, L. and Zhang, M. and Kraemer, N. and Kaindl, A.M. and Fischer, U. and Chen, W.
PLoS Genetics 15 (10): e1008460. 31 October 2019

Small and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate.
Cheng, Z. and Mugler, C.F. and Keskin, A. and Hodapp, S. and Chan, L.Y.L. and Weis, K. and Mertins, P. and Regev, A. and Jovanovic, M. and Brar, G.A.
Molecular Cell 73 (1): 36-47. 3 January 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C. and Rom, A. and Franke, V. and Imami, K. and Arrey, G. and Terne, M. and Woehler, A. and Akalin, A. and Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Cossarizza, A. and Chang, H.D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and Andrä, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and Büscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Čičin-Šain, L. and Clerici, M. 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A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and Grützkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and Hämmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and Jäck, H.M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and Kühne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Leung, L.Y.T. and Levings, M.K. and Lino, A.C. and Liotta, F. and Litwin, V. and Liu, Y. and Ljunggren, H.G. and Lohoff, M. and Lombardi, G. and Lopez, L. and López-Botet, M. and Lovett-Racke, A.E. and Lubberts, E. and Luche, H. and Ludewig, B. and Lugli, E. and Lunemann, S. and Maecker, H.T. and Maggi, L. and Maguire, O. and Mair, Fl. and Mair, K.H. and Mantovani, A. and Manz, R.A. and Marshall, A.J. and Martínez-Romero, A. and Martrus, G. and Marventano, I. and Maslinski, W. and Matarese, G. and Mattioli, A.V. and Maueröder, C. and Mazzoni, A. and McCluskey, J. and McGrath, M. and McGuire, H.M. and McInnes, I.B. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Miller, S.D. and Mills, K.H.G. and Minderman, H. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, L. and Mosmann, T.R. and Müller, S. and Multhoff, G. and Muñoz, L.E. and Münz, C. and Nakayama, T. and Nasi, M. and Neumann, K. and Ng, L.G. and Niedobitek, A. and Nourshargh, S. and Núñez, G. and O'Connor, J.E. and Ochel, A. and Oja, A. and Ordonez, D. and Orfao, A. and Orlowski-Oliver, E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Pattanapanyasat, K. and Paulsen, M. and Pavlinic, D. and Penter, L. and Peterson, P. and Peth, C. and Petriz, J. and Piancone, F. and Pickl, W.F. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Poon, Z. and Pracht, K. and Prinz, I. and Pucillo, C.E.M. and Quataert, S.A. and Quatrini, L. and Quinn, K.M. and Radbruch, H. and Radstake, T.R.D.J. and Rahmig, S. and Rahn, H.P. and Rajwa, B. and Ravichandran, G. and Raz, Y. and Rebhahn, J.A. and Recktenwald, D. and Reimer, D. and Reis E Sousa, C. and Remmerswaal, E.B.M. and Richter, L. and Rico, L.G. and Riddell, A. and Rieger, A.M. and Robinson, J.P and Romagnani, C. and Rubartelli, A. and Ruland, J. and Saalmüller, A. and Saeys, Y. and Saito, T. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sandrock, I. and Santoni, A. and Sanz, R.B. and Saresella, M. and Sautes-Fridman, C. and Sawitzki, B. and Schadt, L. and Scheffold, A. and Scherer, H.U and Schiemann, M. and Schildberg, F.A. and Schimisky, E. and Schlitzer, A. and Schlosser, J. and Schmid, S. and Schmitt, S. and Schober, K. and Schraivogel, D. and Schuh, W. and Schüler, T. and Schulte, R. and Schulz, A.R. and Schulz, S.R. and Scottá, C. and Scott-Algara, D. and Sester, D.P. and Shankey, T.V. and Silva-Santos, B. and Simon, A.K. and Sitnik, K.M. and Sozzani, S. and Speiser, D.E. and Spidlen, J. and Stahlberg, A. and Stall, A.M. and Stanley, N. and Stark, R. and Stehle, C. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Takeda, K. and Tan, L. and Tárnok, A. and Tiegs, G. and Toldi, G. and Tornack, J. and Traggiai, E. and Trebak, M. and Tree, T.I.M. and Trotter, J. and Trowsdale, J. and Tsoumakidou, M. and Ulrich, H. and Urbanczyk, S. and van de Veen, W. and van den Broek, M. and van der Pol, E. and Van Gassen, S. and Van Isterdael, G. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and Voehringer, D. and Volk, H.D. and von Borstel, A. and von Volkmann, K. and Waisman, A. and Walker, R.V. and Wallace, P.K. and Wang, S.A. and Wang, X.M. and Ward, M.D. and Ward-Hartstonge, K.A. and Warnatz, K. and Warnes, G. and Warth, S. and Waskow, C. and Watson, J.V. and Watzl, C. and Wegener, L. and Weisenburger, T. and Wiedemann, A. and Wienands, J. and Wilharm, A. and Wilkinson, R.J. and Willimsky, G. and Wing, J.B. and Winkelmann, R. and Winkler, T.H. and Wirz, O.F. and Wong, A. and Wurst, P. and Yang, J.H.M. and Yang, J. and Yazdanbakhsh, M. and Yu, L. and Yue, A. and Zhang, H. and Zhao, Y. and Ziegler, S.M. and Zielinski, C. and Zimmermann, J. and Zychlinsky, A.
European Journal of Immunology 49 (10): 1457-1973. October 2019

Multi-sample SPIM image acquisition, processing and analysis of vascular growth in zebrafish.
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Development 146 (6): dev173757. 15 March 2019

Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy.
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PRISMA: Protein Interaction Screen on Peptide Matrix reveals interaction footprints and modifications- dependent interactome of intrinsically disordered C/EBPb.
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The choice of embedding media affects image quality, tissue R(2)*, and susceptibility behaviors in post‐mortem brain MR microscopy at 7.0T.
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Magnetic Resonance in Medicine 81 (4): 2688-2701. April 2019

A helminth chitinase structurally similar to mammalian chitinase displays immunomodulatory properties.
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A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.
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Studying Brugada syndrome with an SCN1B variants in human-induced pluripotent stem cell-derived cardiomyocytes.
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Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
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Nature 571 (7765): 429-433. 18 July 2019

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
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Nature Neuroscience 22 (10): 1731-1742. October 2019

Associations of the metabolic syndrome and its components with cognitive impairment in older adults.
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BMC Geriatrics 19 (1): 77. 7 March 2019

Eleven loci with new reproducible genetic associations with allergic disease risk.
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Journal of Allergy and Clinical Immunology 143 (2): 691-699. February 2019

Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells.
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Science Signaling 12 (581): eaao5820. 14 May 2019

Cluster binding studies with two anti-Thomsen-Friedenreich (anti-core-1, CD176, TF) antibodies: evidence for a multiple TF epitope.
Flechner, A. and Butschak, G. and Löffler, A. and Rühmann, J. and Nishimura, S.I. and Dölling, R. and Purfürst, B. and Goletz, S. and Danielczyk, A. and Karsten, U.
International Immunopharmacology 72 : 186-194. July 2019

Modified protocol of harvesting, extraction, and normalization approaches for gas chromatography mass spectrometry-based metabolomics analysis of adherent cells grown under high fetal calf serum conditions.
Fritsche-Guenther, R. and Bauer, A. and Gloaguen, Y. and Lorenz, M. and Kirwan, J.A.
Metabolites 10 (1): 2. 18 December 2019

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.
Funk, N. and Munz, M. and Ott, T. and Brockmann, K. and Wenninger-Weinzierl, A. and Kühn, R. and Vogt-Weisenhorn, D. and Giesert, F. and Wurst, W. and Gasser, T. and Biskup, S.
Scientific Reports 9 (1): 4515. 14 March 2019

Towards depth-resolved characterization of hemodynamics and oxygenation in the rat kidney.
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Near infrared spectroscopy system for quantitative monitoring of renal hemodynamics and oxygenation in rats.
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HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
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Molecular Genetics & Genomic Medicine 7 (5): e602. May 2019

Lung purinoceptor activation triggers ventilator-induced brain injury.
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Critical Care Medicine 47 (11): e911-e918. November 2019

Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.
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Acta Neuropathologica Communications 7 (1): 20. 14 February 2019

MRG-1/MRG15 is a barrier for germ cell to neuron reprogramming in Caenorhabditis elegans.
Hajduskova, M. and Baytek, G. and Kolundzic, E. and Gosdschan, A. and Kazmierczak, M. and Ofenbauer, A. and Beato del Rosal, M.L. and Herzog, S. and ul Fatima, N. and Mertins, P. and Seelk-Müthel, S. and Tursun, B.
Genetics 211 (1): 121-139. 1 January 2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C. and Berger, H. and Antanaviciute, A. and Vidal, R. and Sauer, S. and Simmons, A. and Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

Escalation of memory length in finite populations.
Harrington, K. and Pollack, J.
Artificial Life 25 (1): 22-32. 2 April 2019

Structural features of tight-junction proteins.
Heinemann, U. and Schuetz, A.
International Journal of Molecular Sciences 20 (23): 6020. 29 November 2019

A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Hoff, U. and Bubalo, G. and Fechner, M. and Blum, M. and Zhu, Y. and Pohlmann, A. and Hentschel, J. and Arakelyan, K. and Seeliger, E. and Flemming, B. and Gürgen, D. and Rothe, M. and Niendorf, T. and Manthati, V.L. and Falck, J.R. and Haase, M. and Schunck, W.H. and Dragun, D.
Acta Physiologica 227 (2): e13297. October 2019

Genetics of intellectual disability in consanguineous families.
Hu, H. and Kahrizi, K. and Musante, L. and Fattahi, Z. and Herwig, R. and Hosseini, M. and Oppitz, C. and Abedini, S.S. and Suckow, V. and Larti, F. and Beheshtian, M. and Lipkowitz, B. and Akhtarkhavari, T. and Mehvari, S. and Otto, S. and Mohseni, M. and Arzhangi, S. and Jamali, P. and Mojahedi, F. and Taghdiri, M. and Papari, E. and Soltani Banavandi, M.J. and Akbari, S. and Tonekaboni, S.H. and Dehghani, H. and Ebrahimpour, M.R. and Bader, I. and Davarnia, B. and Cohen, M. and Khodaei, H. and Albrecht, B. and Azimi, S. and Zirn, B. and Bastami, M. and Wieczorek, D. and Bahrami, G. and Keleman, K. and Vahid, L.N. and Tzschach, A. and Gärtner, J. and Gillessen-Kaesbach, G. and Varaghchi, J.R. and Timmermann, B. and Pourfatemi, F. and Jankhah, A. and Chen, W. and Nikuei, P. and Kalscheuer, V.M. and Oladnabi, M. and Wienker, T.F. and Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 24 (7): 1027-1039. July 2019

SURF1 mutations causative of Leigh syndrome impair human neurogenesis.
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bioRxiv : 551390. 20 February 2019

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
James, A.R. and Schroeder, M.P. and Neumann, M. and Bastian, L. and Eckert, C. and Gökbuget, N. and Tanchez, J.O. and Schlee, C. and Isaakidis, K. and Schwartz, S. and Burmeister, T. and von Stackelberg, A. and Rieger, M.A. and Göllner, S. and Horstman, M. and Schrappe, M. and Kirschner-Schwabe, R. and Brüggemann, M. and Müller-Tidow, C. and Serve, H. and Akalin, A. and Baldus, C.D.
Journal of Hematology & Oncology 12 (1): 8. 14 January 2019

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.
Jochner, M.C.E. and An, J. and Lättig-Tünnemann, G. and Kirchner, M. and Dagane, A. and Dittmar, G. and Dirnagl, U. and Eickholt, B.J. and Harms, C.
Scientific Reports 9 (1): 3183. 28 February 2019

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined.
Kaleviste, E. and Saare, M. and Leahy, T.R. and Bondet, V. and Duffy, D. and Mogensen, T. and Jørgensen, S.E. and Nurm, H. and Ip, W. and Davies, E.G. and Sauer, S. and Syvänen, A.C. and Milani, L. and Peterson, P. and Kisand, K.
European Journal of Immunology 49 (5): 790-800. May 2019

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
Karabacak Calviello, A. and Hirsekorn, A. and Wurmus, R. and Yusuf, D. and Ohler, U.
Genome Biology 20 (1): 42. 21 February 2019

Vinylphosphonites for staudinger-induced chemoselective peptide cyclization and functionalization.
Kasper, M.A and Glanz, M. and Oder, A. and Schmieder, P. and von Kries, J.P. and Hackenberger, C.P.R.
Chemical Science 10 (25): 6322-6329. 7 July 2019

Systems biology approach to study cancer metabolism.
Kempa, S. and Royla, N.
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Biobanking for metabolomics and lipidomics in precision medicine.
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Clinical Chemistry 65 (7): 827-832. 28 June 2019

Cognitive impairment is associated with absolute intraoperative frontal α-band power but not with baseline α-band power: a pilot study.
Koch, S. and Feinkohl, I. and Chakravarty, S. and Windmann, V. and Lichtner, G. and Pischon, T. and Brown, E.N. and Spies, C.
Dementia and Geriatric Cognitive Disorders 48 : 1-2. December 2019

A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Milanovic, M. and Tufan, A.B. and Uyar, B. and Sun, W. and Schleich, K. and von Hoff, L. and Willenbrock, M. and Krahn, I. and Jungmann, S. and Hinz, M. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
bioRxiv : 2019.12.19.882225. 20 December 2019

Janggu: deep learning for genomics.
Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
bioRxiv : 700450. 16 July 2019

A curated resource for phosphosite-specific signature analysis.
Krug, K. and Mertins, P. and Zhang, B. and Hornbeck, P. and Raju, R. and Ahmad, R. and Szucs, M. and Mundt, F. and Forestier, D. and Jane-Valbuena, J. and Keshishian, H. and Gillette, M.A. and Tamayo, P. and Mesirov, J.P. and Jaffe, J.D. and Carr, S.A. and Mani, D.R.
Molecular & Cellular Proteomics 18 (3): 576-593. 1 March 2019

AltamISA: a Python API for ISA-Tab files.
Kuhring, M. and Nieminen, M. and Kirwan, J. and Beule, D. and Holtgrewe, M.
Journal of Open Source Software 4 (40): 1610. 20 August 2019

Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.
Kühnisch, J. and Herbst, C. and Al-Wakeel-Marquard, N. and Dartsch, J. and Holtgrewe, M. and Baban, A. and Mearini, G. and Hardt, J. and Kolokotronis, K. and Gerull, B. and Carrier, L. and Beule, D. and Schubert, S. and Messroghli, D. and Degener, F. and Berger, F. and Klaassen, S.
Clinical Genetics 96 (6): 549-559. December 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. and Peng, S. and Klironomos, F. and Munschauer, M. and Kastelic, N. and Chakraborty, T. and Schoeler, K. and Derudder, E. and Martella, M. and Mastrobuoni, G. and Hernandez-Miranda, L.R. and Lahmann, I. and Kocks, C. and Birchmeier, C. and Kempa, S. and Quintanilla-Martinez de Fend, L. and Landthaler, M. and Rajewsky, N. and Rajewsky, K.
Genes & Development 33 : 23-24. 7 November 2019

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Lahmann, I. and Bröhl, D. and Zyrianova, T. and Isomura, A. and Czajkowski, M.T. and Kapoor, V. and Griger, J. and Ruffault, P.L. and Mademtzoglou, D. and Zammit, P.S. and Wunderlich, T. and Spuler, S. and Kühn, R. and Preibisch, S. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Genes & Development 33 (9-10): 524-535. 1 May 2019

Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application.
Lang, A. and Kirchner, M. and Stefanowski, J. and Durst, M. and Weber, M.C. and Pfeiffenberger, M. and Damerau, A. and Hauser, A.E. and Hoff, P. and Duda, G.N. and Buttgereit, F. and Schmidt-Bleek, K. and Gaber, T.
Acta Biomaterialia 86 : 171-184. 1 March 2019

Social networks and protest participation: evidence from 130 million Twitter users.
Larson, J.M. and Nagler, J. and Ronen, J. and Tucker, J.A.
American Journal of Political Science 63 (3): 690-705. July 2019

Efficient and precise CRISPR/Cas9-mediated MECP2 modifications in human-induced pluripotent stem cells.
Le, T.T.H. and Tran, N.T. and Dao, T.M.L. and Nguyen, D.D. and Do, H.D. and Ha, T.L. and Kühn, R. and Nguyen, T.L. and Rajewsky, K. and Chu, V.T.
Frontiers in Genetics 10 : 625. July 2019

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J. and Termglinchan, V. and Diecke, S. and Itzhaki, I. and Lam, C.K. and Garg, P. and Lau, E. and Greenhaw, M. and Seeger, T. and Wu, H. and Zhang, J.Z and Chen, X. and Gil, I.P. and Ameen, M. and Sallam, K. and Rhee, J.W. and Churko, J.M. and Chaudhary, R. and Chour, T. and Wang, P.J. and Snyder, M.P. and Chang, H.Y. and Karakikes, I. and Wu, J.C.
Nature 572 (7769): 335-340. 15 August 2019

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.
Leisegang, M.S. and Gu, L. and Preussner, J. and Günther, S. and Hitzel, J. and Ratiu, C. and Weigert, A. and Chen, W. and Schwarz, E.C. and Looso, M. and Fork, C. and Brandes, R.P.
FEBS Letters 593 (5): 487-498. March 2019

Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs.
Lorenz, M. and Blaschke, B. and Benn, A. and Hammer, E. and Witt, E. and Kirwan, J. and Fritsche-Guenther, R. and Gloaguen, Y. and Bartsch, C. and Vietzke, A. and Kramer, F. and Kappert, K. and Brunner, P. and Nguyen, H.G. and Dreger, H. and Stangl, K. and Knaus, P. and Stangl, V.
Atherosclerosis 291 : 99-106. December 2019

Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development.
Lupberger, J. and Croonenborghs, T. and Roca Suarez, A.A. and Van Renne, N. and Jühling, F. and Oudot, M.A. and Virzì, A. and Bandiera, S. and Jamey, C. and Meszaros, G. and Brumaru, D. and Mukherji, A. and Durand, S.C. and Heydmann, L. and Verrier, E.R. and El Saghire, H. and Hamdane, N. and Bartenschlager, R. and Fereshetian, S. and Ramberger, E. and Sinha, R. and Nabian, M. and Everaert, C. and Jovanovic, M. and Mertins, P. and Carr, S.A. and Chayama, K. and Dali-Youcef, N. and Ricci, R. and Bardeesy, N.M. and Fujiwara, N. and Gevaert, O. and Zeisel, M.B. and Hoshida, Y. and Pochet, N. and Baumert, T.F.
Gastroenterology 157 (2): 537-551. August 2019

SorCS2 controls functional expression of amino acid transporter EAAT3 and protects neurons from oxidative stress and epilepsy-induced pathology.
Malik, A.R. and Szydlowska, K. and Nizinska, K. and Asaro, A. and van Vliet, E.A. and Popp, O. and Dittmar, G. and Fritsche-Guenther, R. and Kirwan, J.A. and Nykjaer, A. and Lukasiuk, K. and Aronica, E. and Willnow, T.E.
Cell Reports 26 (10): 2792-2804. 5 March 2019

A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathy.
Marcinkowski, P. and Hoyer, I. and Specker, E. and Furkert, J. and Rutz, C. and Neuenschwander, M. and Sobottka, S. and Sun, H. and Nazare, M. and Berchner-Pfannschmidt, U. and von Kries, J.P. and Eckstein, A. and Schülein, R. and Krause, G.
Thyroid 29 (1): 111-123. 23 January 2019

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A. and Escobar Fernandez, H. and Karaiskos, N. and Grunwald, S.A. and Metzler, E. and Kieshauer, J. and Sauer, S. and Pasemann, D. and Malfatti, E. and Mompoint, D. and Quijano-Roy, S. and Boltengagen, A. and Schneider, J. and Schülke, M. and Kunz, S. and Carlier, R. and Birchmeier, C. and Amthor, H. and Spuler, A. and Kocks, C. and Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization.
Matthaeus, C. and Lian, X. and Kunz, S. and Lehmann, M. and Zhong, C. and Bernert, C. and Lahmann, I. and Müller, D.N. and Gollasch, M. and Daumke, O.
PLoS ONE 14 (10): e0223620. 10 October 2019

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake.
Matthäus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Alves Melo, A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
bioRxiv : 511709. 7 March 2019

High-throughput screening for modulators of CFTR activity based on genetically engineered cystic fibrosis disease-specific iPSCs.
Merkert, S. and Schubert, M. and Olmer, R. and Engels, L. and Radetzki, S. and Veltman, M. and Scholte, B.J. and Zöllner, J. and Pedemonte, N. and Galietta, L.J.V. and von Kries, J.P. and Martin, U.
Stem Cell Reports 12 (6): 1389-1403. 11 June 2019

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.
Messerschmidt, C. and Obermayer, B. and Klinghammer, K. and Ochsenreither, S. and Treue, D. and Stenzinger, A. and Glimm, H. and Fröhling, S. and Kindler, T. and Brandts, C.H. and Schulze-Osthoff, K. and Weichert, W. and Tinhofer, I. and Klauschen, F. and Keilholz, U. and Beule, D. and Rieke, D.T.
bioRxiv : 586396. 28 March 2019

Application of europium-doped very small iron oxide nanoparticles to visualize neuroinflammation with MRI and fluorescence microscopy.
Millward, J.M. and de Schellenberger, A.A. and Berndt, D. and Hanke-Vela, L. and Schellenberger, E. and Waiczies, S. and Taupitz, M. and Kobayashi, Y. and Wagner, S. and Infante-Duarte, C.
Neuroscience 403 : 136-144. 1 April 2019

The conserved histone chaperone LIN-53 links lifespan and healthspan regulation in C. elegans.
Muethel, S. and Uyar, B. and He, M. and Krause, A. and Vitrinel, B. and Bulut, S. and Vasiljevic, D. and Akalin, A. and Kempa, S. and Tursun, B.
bioRxiv : 539015. 2 February 2019

Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
Mugahid, D.A. and Sengul, T.G. and You, X. and Wang, Y. and Steil, L. and Bergmann, N. and Radke, M.H. and Ofenbauer, A. and Gesell-Salazar, M. and Balogh, A. and Kempa, S. and Tursun, B. and Robbins, C.T. and Völker, U. and Chen, W. and Nelson, L. and Gotthardt, M.
Scientific Reports 9 (1): 19976. 27 December 2019

Deciphering human ribonucleoprotein regulatory networks.
Mukherjee, N. and Wessels, H.H. and Lebedeva, S. and Sajek, M. and Ghanbari, M. and Garzia, A. and Munteanu, A. and Yusuf, D. and Farazi, T. and Hoell, J.I. and Akat, K.M. and Akalin, A. and Tuschl, T. and Ohler, U.
Nucleic Acids Research 47 (2): 570-581. 25 January 2019

The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans.
Müthel, S. and Uyar, B. and He, M. and Krause, A. and Vitrinel, B. and Bulut, S. and Vasiljevic, D. and Marchal, I. and Kempa, S. and Akalin, A. and Tursun, B.
Aging Cell 18 (6): e13012. December 2019

Human cardiac magnetic resonance at ultrahigh fields : technical innovations, early clinical applications and opportunities for discoveries.
Niendorf, T. and Huelnhagen, T. and Winter, L. and Paul, K.
In: Cardiovascular magnetic resonance : a companion to Braunwald's heart disease. Elsevier, Philadelphia, PA, 142-160. ISBN 978-0-323-41561-3 2019

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Nowak, M. and Suenkel, B. and Porras, P. and Migotti, R. and Schmidt, F. and Kny, M. and Zhu, X. and Wanker, E.E. and Dittmar, G. and Fielitz, J. and Sommer, T.
Journal of Cell Science 132 (17): jcs233395. 6 September 2019

Characterization of bacterial communities in wastewater with enhanced taxonomic resolution by full-length 16S rRNA sequencing.
Numberger, D. and Ganzert, L. and Zoccarato, L. and Mühldorfer, K. and Sauer, S. and Grossart, H.P. and Greenwood, A.D.
Scientific Reports 9 (1): 9673. 4 July 2019

SCelVis: Powerful explorative single cell data analysis on the desktop and in the cloud.
Obermayer, B. and Holtgrewe, M. and Nieminen, M. and Messerschmidt, C. and Beule, D.
bioRxiv : 713008. 24 July 2019

Quantitative 7T MRI does not detect occult brain damage in neuromyelitis optica.
Pasquier, B. and Borisow, N. and Rasche, L. and Bellmann-Strobl, J. and Ruprecht, K. and Niendorf, T. and Derfuss, T.J. and Wuerfel, J. and Paul, F. and Sinnecker, T.
Neurology Neuroimmunology & Neuroinflammation 6 (3): e541. May 2019

Small-molecule lysophosphatidic acid receptor 5 (LPAR5) antagonists: versatile pharmacological tools to regulate inflammatory signaling in BV-2 microglia cells.
Plastira, I. and Joshi, L. and Bernhart, E. and Schoene, J. and Specker, E. and Nazare, M. and Sattler, W.
Frontiers in Cellular Neuroscience 13 : 531. 29 December 2019

Toward (19)F magnetic resonance thermometry: spin-lattice and spin-spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T.
Prinz, C. and Delgado, P.R. and Eigentler, T.W. and Starke, L. and Niendorf, T. and Waiczies, S.
Magnetic Resonance Materials in Physics Biology and Medicine 32 (1): 51-61. February 2019

Functional annotation of human long non-coding RNAs via molecular phenotyping.
Ramilowski, J. and Yip, C.W. and Agrawal, S. and Chang, J.C. and Ciani, Y. and Kulakovskiy, I.V. and Mendez, M. and Ooi, J.L.C. and Ouyang, J.F. and Parkinson, N. and Petri, A. and Roos, L. and Severin, J. and Yasuzawa, K. and Abugessaisa, I. and Akalin, A. and Antonov, I. and Arner, E. and Bonetti, A. and Bono, H. and Borsari, B. and Brombacher, F. and Cannistraci, C.V. and Cameron, C.J.F. and Cardenas, R. and Cardon, M. and Chang, H. and Dostie, J. and Ducoli, L. and Favorov, A. and Fort, A. and Garrido, D. and Gil, N. and Gimenez, J. and Guler, R. and Handoko, L. and Harshbarger, J. and Hasegawa, A. and Hasegawa, Y. and Hashimoto, K. and Hayatsu, N. and Heutink, P. and Hirose, T. and Imada, E.L. and Itoh, M. and Kaczkowski, B. and Kanhere, A. and Kawabata, E. and Kawaji, H. and Kawashima, T. and Kelly, T. and Kojima, M. and Kondo, N. and Koseki, H. and Kouno, T. and Kratz, A. and Kurowska-Stolarska, M. and Kwon, A.T.J. and Leek, J. and Lennartsson, A. and Lizio, M. and Lopez, F. and Luginbühl, J. and Maeda, S. and Makeev, V. and Marchionni, L. and Medvedeva, Y.A. and Minoda, A. and Müller, F. and Aguirre, M.M. and Murata, M. and Nishiyori, H. and Nitta, K. and Noguchi, S. and Noro, Y. and Nurtdinov, R. and Okazaki, Y. and Orlando, V. and Paquette, D. and Parr, C. and Rackham, O.J.L. and Rizzu, P. and Sanchez, D.F. and Sandelin, A. and Sanjana, P. and Semple, C.A.M. and Sharma, H. and Shibayama, Y. and Sivaraman, D. and Suzuki, T. and Szumowski, S. and Tagami, M. and Taylor, M.S. and Terao, C. and Thodberg, M. and Thongjuea, S. and Tripathi, V. and Ulitsky, I. and Verardo, R. and Vorontsov, I. and Yamamoto, C. and Young, R.S. and Baillie, J.K. and Forrest, A.R.R. and Guigó, R. and Hoffman, M.M. and Hon, C.C. and Kasukawa, T. and Kauppinen, S. and Kere, J. and Lenhard, B. and Schneider, C. and Suzuki, H. and Yagi, K. and de Hoon, M. and Shin, J.W. and Carninci, P.
bioRxiv : 700864. 18 July 2019

Porous medium 3D flow simulation of contrast media washout in cardiac MRI reflects myocardial injury.
Riazy, L. and Schaeffter, T. and Olbrich, M. and Schueler, J. and von Knobelsdorff-Brenkenhoff, F. and Niendorf, T. and Schulz-Menger, J.
Magnetic Resonance in Medicine 82 (2): 775-785. August 2019

Clonality of circulating tumor cells in breast cancer brain metastasis patients.
Riebensahm, C. and Joosse, S.A. and Mohme, M. and Hanssen, A. and Matschke, J. and Goy, Y. and Witzel, I. and Lamszus, K. and Kropidlowski, J. and Petersen, C. and Kolb-Kokocinski, A. and Sauer, S. and Borgmann, K. and Glatzel, M. and Müller, V. and Westphal, M. and Riethdorf, S. and Pantel, K. and Wikman, H.
Breast Cancer Research and Treatment 21 (1): 101. 3 September 2019

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.
Rohwer, N. and Jumpertz, S. and Erdem, M. and Egners, A. and Warzecha, K.T. and Fragoulis, At. and Kühl, A.A. and Kramann, R. and Neuss, S. and Rudolph, I. and Endermann, T. and Zasada, C. and Apostolova, I. and Gerling, M. and Kempa, S. and Hughes, R. and Lewis, C.E. and Brenner, W. and Malinowski, M.B. and Stockmann, M. and Schomburg, L. and Faller, W. and Sansom, O.J. and Tacke, F. and Morkel, M. and Cramer, T.
Oncogene 38 (28): 5670-5685. 11 July 2019

Evaluation of colorectal cancer subtypes and cell lines using deep learning.
Ronen, J. and Hayat, S. and Akalin, A.
Life Science Alliance 2 (6): 201900517. December 2019

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M. and Wachowska, M. and Cook, E.C. and Lisowski, P. and Kuźniewska, B. and Szymańska, K. and Diecke, S. and Prigione, A. and Szczałuba, K. and Szybińska, A. and Koppolu, A. and Murcia Pienkowski, V. and Kosińska, J. and Wiweger, M. and Kostrzewa, G. and Brzozowska, M. and Domańska-Pakieła, D. and Jurkiewicz, E. and Stawiński, P. and Gromadka, A. and Zielenkiewicz, P. and Demkow, U. and Dziembowska, M. and Kuźnicki, J. and Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 27 (1): 61-69. January 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels.
Schewe, M. and Sun, H. and Mert, Ü. and Mackenzie, A. and Pike, A.C.W. and Schulz, F. and Constantin, C. and Vowinkel, K.S. and Conrad, L.J. and Kiper, A.K. and Gonzalez, W. and Musinszki, M. and Tegtmeier, M. and Pryde, D.C. and Belabed, H. and Nazare, M. and de Groot, B.L. and Decher, N. and Fakler, B. and Carpenter, E.P. and Tucker, S.J. and Baukrowitz, T.
Science 363 (6429): 875-880. 22 February 2019

Deregulated splicing is a major mechanism of RNA-induced toxicity in Huntington's disease.
Schilling, J. and Broemer, M. and Atanassov, I. and Duernberger, Y. and Vorberg, I. and Dieterich, C. and Dagane, A. and Dittmar, G. and Wanker, E. and van Roon-Mom, W. and Winter, J. and Krauß, S.
Journal of Molecular Biology 431 (9): 1869-1877. 19 April 2019

Probing 2H-indazoles as template for SGK1, Tie2 and SRC kinase inhibitors.
Schoene, J. and Gazzi, T. and Lindemann, P. and Christmann, M. and Volkamer, A. and Nazaré, M.
ChemMedChem 14 (16): 1514-1527. 20 August 2019

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
Schulz, A. and Müller, N.V. and van de Lest, N.A. and Eisenreich, A. and Schmidbauer, M. and Barysenka, A. and Purfürst, B. and Sporbert, A. and Lorenzen, T. and Meyer, A.M. and Herlan, L. and Witten, A. and Rühle, F. and Zhou, W. and de Heer, E. and Scharpfenecker, M. and Panáková, D. and Stoll, M. and Kreutz, R.
eLife 8 : e42068. 22 March 2019

SigsPack, a package for cancer mutational signatures.
Schumann, F. and Blanc, E. and Messerschmidt, C. and Blankenstein, T. and Busse, A. and Beule, D.
BMC Bioinformatics 20 (1): 450. 2 September 2019

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage.
Sharir, A. and Marangoni, P. and Zilionis, R. and Wan, M. and Wald, T. and Hu, J.K. and Kawaguchi, K. and Castillo-Azofeifa, D. and Epstein, L. and Harrington, K. and Pagella, P. and Mitsiadis, T. and Siebel, C.W. and Klein, A.M. and Klein, O.D.
Nature Cell Biology 21 (9): 1102-1112. September 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M. and Del Mar Reinés, M. and Müllerke, S. and Fischer, C. and Kapalczynska, M. and Berger, H. and Bakker, E.R.M. and Mollenkopf, H.J. and Rothenberg, M.E. and Wiedenmann, B. and Sauer, S. and Meyer, T.F.
Nature Cell Biology 21 (7): 812-823. July 2019

Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling, S.A. and Fiedler, P. and Lechner, M. and Pollithy, A. and Ehrenberg, S. and Schiefer, A.I. and Kenner, L. and Feuchtinger, A. and Kühn, R. and Swinerd, G. and Schmidt-Supprian, M. and Strobl, L.J. and Zimber-Strobl, U.
Blood 133 (24): 2597-2609. 13 June 2019

Scalable workflows and reproducible data analysis for genomics.
Strozzi, F. and Janssen, R. and Wurmus, R. and Crusoe, M.R. and Githinji, G. and Di Tommaso, P. and Belhachemi, D. and Möller, S. and Smant, G. and de Ligt, J. and Prins, P.
Methods in Molecular Biology 1910 : 723-745. 2019

Cardiac magnetic resonance imaging at 7 Tesla.
Stäb, D. and Al Najjar, A. and O'Brien, K. and Strugnell, W. and Richer, J. and Rieger, J. and Niendorf, T. and Barth, M.
Journal of Visualized Experiments (143): e55853. 6 January 2019

Fast cross correlation for limited angle tomographic data.
Sánchez, R.M. and Mester, R. and Kudryashev, M.
Lecture Notes in Computer Science 11482 : 415-426. 2019

The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2: a phosphatidylserine flippase.
Theorin, L. and Faxén, K. and Sørensen, D.M. and Migotti, R. and Dittmar, G. and Schiller, J. and Daleke, D.L. and Palmgren, M. and López-Marqués, R.L. and Pomorski, T.G.
Biochemical Journal 476 (5): 783-794. 6 March 2019

Enhancement of precise gene editing by the association of Cas9 with homologous recombination factors.
Tran, N.T. and Bashir, S. and Li, X. and Rossius, J. and Chu, V.T. and Rajewsky, K. and Kühn, R.
Frontiers in Genetics 10 : 365. 30 April 2019

Efficient CRISPR/Cas9-mediated gene knockin in mouse hematopoietic stem and progenitor cells.
Tran, N.T. and Sommermann, T. and Graf, R. and Trombke, J. and Pempe, J. and Petsch, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Cell Reports 28 (13): 3510-3522. 24 September 2019

UbiFast, a rapid and deep-scale ubiquitylation profiling approach for biology and translational research.
Udeshi, N.D. and Mani, D.C. and Satpathy, S. and Fereshetian, S. and Gasser, J.A. and Svinkina, T. and Ebert, B.L. and Mertins, P. and Carr, S.A.
bioRxiv : 785378. 27 September 2019

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.
Ullrich, F. and Blin, S. and Lazarow, K. and Daubitz, T. and von Kries, J.P. and Jentsch, T.J.
eLife 8 : e49187. 18 July 2019

Identification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels.
Ullrich, F. and Blin, S. and Lazarow, K. and Daubitz, T. and von Kries, J.P. and Jentsch, T.J.
bioRxiv : 667600. 11 June 2019

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities.
Vasaikar, S. and Huang, C. and Wang, X. and Petyuk, V.A. and Savage, S.R. and Wen, B. and Dou, Y. and Zhang, Y. and Shi, Z. and Arshad, O.A. and Gritsenko, M.A. and Zimmerman, L.J. and McDermott, J.E. and Clauss, T.R. and Moore, R.J. and Zhao, R. and Monroe, M.E. and Wang, Y.T. and Chambers, M.C. and Slebos, R.J.C. and Lau, K.S. and Mo, Q. and Ding, L. and Ellis, M. and Thiagarajan, M. and Kinsinger, C.R. and Rodriguez, H. and Smith, R.D. and Rodland, K.D. and Liebler, D.C. and Liu, T. and Zhang, B.
Cell 177 (4): 1035-1049. 2 May 2019

Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.
Vidal, R. and Wagner, J.U.G. and Braeuning, C. and Fischer, C. and Patrick, R. and Tombor, L. and Muhly-Reinholz, M. and John, D. and Kliem, M. and Conrad, T. and Guimarães-Camboa, N. and Harvey, R. and Dimmeler, S. and Sauer, S.
JCI Insight 4 (22): e131092. 14 November 2019

Fluorine-19 MRI at 21.1 T: enhanced spin-lattice relaxation of perfluoro-15-crown-5-ether and sensitivity as demonstrated in ex vivo murine neuroinflammation.
Waiczies, S. and Rosenberg, J.T. and Kuehne, A. and Starke, L. and Delgado, P.R. and Millward, J. and Prinz, C. and dos Santos Periquito, J. and Pohlmann, A. and Waiczies, H. and Niendorf, T.
Magnetic Resonance Materials in Physics Biology and Medicine 32 (1): 37-49. February 2019

Special issue on fluorine-19 magnetic resonance: technical solutions, research promises and frontier applications.
Waiczies, S. and Srinivas, M. and Flögel, U. and Boehm-Sturm, P. and Niendorf, T.
Magnetic Resonance Materials in Physics Biology and Medicine 32 (1): 1-3. February 2019

Long and repeat-rich intronic sequences favor circular RNA formation under conditions of reduced spliceosome activity.
Wang, M. and Hou, J. and Müller-McNicoll, M. and Chen, W. and Schuman, E.M.
iScience 20 : 237-247. 25 October 2019

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X. and You, X. and Langer, J.D. and Hou, J. and Rupprecht, F. and Vlatkovic, I. and Quedenau, C. and Tushev, G. and Epstein, I. and Schaefke, B. and Sun, W. and Fang, L. and Li, G. and Hu, Y. and Schuman, E.M. and Chen, W.
Nature Communications 10 (1): 5009. 1 November 2019

A novel allele for inducible Cre expression in germinal center B cells.
Weber, T. and Seagal, J. and Winkler, W. and Wirtz, T. and Chu, V.T. and Rajewsky, K.
European Journal of Immunology 49 (1): 192-194. January 2019

Splicing factor Rbm10 facilitates heterochromatin assembly in fission yeast.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
bioRxiv : 518936. 11 January 2019

Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H. and Lebedeva, S. and Hirsekorn, A. and Wurmus, R. and Akalin, A. and Mukherjee, N. and Ohler, U.
Nature Communications 10 (1): 1626. 9 April 2019

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L’hernault, A. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Chunguang, L. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
bioRxiv : 603654. 9 April 2019

The cell adhesion protein CAR is a negative regulator of synaptic transmission.
Wrackmeyer, U. and Kaldrack, J. and Jüttner, R. and Pannasch, U. and Gimber, N. and Freiberg, F. and Purfürst, B. and Kainmueller, D. and Schmitz, D. and Haucke, V. and Rathjen, F.G. and Gotthardt, M.
Scientific Reports 9 (1): 6768. 1 May 2019

HOT or not: examining the basis of high-occupancy target regions.
Wreczycka, K. and Franke, V. and Uyar, B. and Wurmus, R. and Bulut, S. and Tursun, B. and Akalin, A.
Nucleic Acids Research : gkz460. 20 June 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Bosse, J. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
bioRxiv : 566992. 4 March 2019

Efficient gene editing of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S. and Bashir, S. and Stumm, J. and Kühn, R.
Methods in Molecular Biology 1961 : 137-151. 2019

TMT labeling for the masses: a robust and cost-efficient, in-solution labeling approach.
Zecha, J. and Satpathy, S. and Kanashova, T. and Avanessian, S.C. and Kane, M.H. and Clauser, K.R. and Mertins, P. and Carr, S.A. and Kuster, B.
Molecular & Cellular Proteomics 18 (7): 1468-1478. 1 July 2019

Rapid synthesis of γ-halide/pseudohalide-substituted cyanine sensors with programmed generation of singlet oxygen.
Zhang, Q. and Xu, S. and Lai, F. and Wang, Y. and Zhang, N. and Nazare, M. and Hu, H.Y.
Organic Letters 21 (7): 2121-2125. 5 April 2019

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, X. and Nedvetsky, P. and Stanchi, F. and Vion, A.C. and Popp, O. and Zühlke, K. and Dittmar, G. and Klussmann, E. and Gerhardt, H.
eLife 8 : e46380. 3 October 2019

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy.
Zhao, X. and Nedvetsky, P. and Vion, A.C. and Popp, O. and Zühlke, K. and Dittmar, G. and Klussmann, E. and Gerhardt, H.
bioRxiv : 573683. 12 March 2019

The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer.
Zhu, Q. and Fang, L. and Heuberger, J. and Kranz, A. and Schipper, J. and Scheckenbach, K. and Oliveira Vidal, R. and Sunaga-Franze, D.Y. and Müller, M. and Wulf-Goldenberg, A. and Sauer, S. and Birchmeier, W.
Cell Reports 26 (2): 415-428. 8 January 2019

Diffusion-weighted renal MRI at 9.4 Tesla using RARE to improve anatomical integrity.
dos Santos Periquito, J. and Paul, K. and Huelnhagen, T. and Ku, M.C. and Ji, Y. and Cantow, K. and Gladytz, T. and Grosenick, D. and Flemming, B. and Seeliger, E. and Waiczies, S. and Niendorf, T. and Pohlmann, A.
Scientific Reports 9 (1): 19723. 23 December 2019

The translational landscape of the human heart.
van Heesch, S. and Witte, F. and Schneider-Lunitz, V. and Schulz, J.F. and Adami, E. and Faber, A. and Kirchner, M. and Maatz, H. and Blachut, S. and Sandmann, C.L. and Kanda, M. and Worth, C.L. and Schafer, S. and Calviello, L. and Merriott, R. and Patone, G. and Hummel, O. and Wyler, E. and Obermayer, B. and Mücke, M. and Lindberg, E.L. and Trnka, F. and Memczak, S. and Schilling, M. and Felkin, L.E. and Barton, P.J.R. and Quaife, N.M. and Vanezis, K. and Diecke, S. and Mukai, M. and Mah, N. and Oh, S.J. and Kurtz, A. and Schramm, C. and Schwinge, D. and Sebode, M. and Harakalova, M. and Asselbergs, F.W. and Vink, A. and de Weger, R.A. and Viswanathan, S. and Widjaja, A.A. and Gärtner-Rommel, A. and Milting, H. and Dos Remedios, C. and Knosalla, C. and Mertins, P. and Landthaler, M. and Vingron, M. and Linke, W.A. and Seidman, J.G. and Seidman, C.E. and Rajewsky, N. and Ohler, U. and Cook, S.A. and Hubner, N.
Cell 178 (1): 242-260. 27 June 2019

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.
von Hoff, L. and Kärgel, E. and Franke, V. and McShane, E. and Schulz-Beiss, K.W. and Patone, G. and Schleussner, N. and Kolesnichenko, M. and Hübner, N. and Daumke, O. and Selbach, M. and Akalin, A. and Mathas, S. and Scheidereit, C.
Blood 133 (13): 1489-1494. 28 March 2019

2018

The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
Althof, N. and Goetzke, C.C. and Kespohl, M. and Voss, K. and Heuser, A. and Pinkert, S. and Kaya, Z. and Klingel, K. and Beling, A.
EMBO Molecular Medicine 10 (2): 200-218. 1 February 2018

Proteomics, post-translational modifications, and integrative analyses reveal molecular heterogeneity within medulloblastoma subgroups.
Archer, T.C. and Ehrenberger, T. and Mundt, F. and Gold, M.P. and Krug, K. and Mah, C.K. and Mahoney, E.L. and Daniel, C.J. and LeNail, A. and Ramamoorthy, D. and Mertins, P. and Mani, D.R. and Zhang, H. and Gillette, M.A. and Clauser, K. and Noble, M. and Tang, L.C. and Pierre-François, J. and Silterra, J. and Jensen, J. and Tamayo, P. and Korshunov, A. and Pfister, S.M. and Kool, M. and Northcott, P.A. and Sears, R.C. and Lipton, J.O. and Carr, S.A. and Mesirov, J.P. and Pomeroy, S.L. and Fraenkel, E.
Cancer Cell 34 (3): 396-410. 10 September 2018

Allosteric inhibition of a mammalian lectin.
Aretz, J. and Anumala, U.R. and Fuchsberger, F.F. and Molavi, N. and Ziebart, N. and Zhang, H. and Nazaré, M. and Rademacher, C.
Journal of the American Chemical Society 140 (44): 14915-14925. 7 November 2018

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y. and Eslami, A. and van Ginkel, C.D. and Akhabir, L. and Wan, M. and Yin, D. and Ellis, G. and Ben-Shoshan, M. and Marenholz, I. and Martino, D. and Ferreira, M.A. and Allen, K. and Mazer, B. and de Groot, H. and de Jong, N.W. and Gerth van Wijk, R. and Dubois, A.E.J. and Grosche, S. and Ashley, S. and Rüschendorf, F. and Kalb, B. and Beyer, K. and Nöthen, M.M. and Lee, Y.A. and Chin, R. and Cheuk, S. and Hoffman, J. and Jorgensen, E. and Witte, J.S. and Melles, R.B. and Hong, X. and Wang, X. and Hui, J. and Musk, A.W.B. and Hunter, M. and James, A.L. and Koppelman, G.H. and Sandford, A.J. and Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141 (4): 1513-1516. April 2018

Chronic overexpression of bradykinin in kidney causes polyuria and cardiac hypertrophy.
Barros, C.C. and Schadock, I. and Sihn, G. and Rother, F. and Xu, P. and Popova, E. and Lapidus, I. and Plehm, R. and Heuser, A. and Todiras, M. and Bachmann, S. and Alenina, N. and Araujo, R.C. and Pesquero, J.B. and Bader, M.
Frontiers in Medicine 5 : 338. December 2018

7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions.
Behrens, J.R. and Wanner, J. and Kuchling, J. and Ostendorf, L. and Harms, L. and Ruprecht, K. and Niendorf, T. and Jarius, S. and Wildemann, B. and Gieß, R.M. and Scheel, M. and Bellmann-Strobl, J. and Wuerfel, J. and Paul, F. and Sinnecker, T.
Annals of Clinical and Translational Neurology 5 (8): 900-912. August 2018

Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives.
Bel Abed, H. and Weißing, N. and Schoene, J. and Paulus, J. and Sewald, N. and Nazaré, M.
Tetrahedron Letters 59 (19): 1813-1815. 9 May 2018

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Berndt, N. and Egners, A. and Mastrobuoni, G. and Vvedenskaya, O. and Fragoulis, A. and Dugourd, A. and Bulik, S. and Pietzke, M. and Bielow, C. and van Gassel, R. and Olde Damink, S. and Erdem, M. and Saez-Rodriguez, J. and Holzhütter, H.G. and Kempa, S. and Cramer, T.
bioRxiv : 275040. 5 March 2018

Identification and ranking of recurrent neo-epitopes in cancer.
Blanc, E. and Holtgrewe, M. and Dhamodaran, A. and Messerschmidt, C. and Willimsky, G. and Blankenstein, T. and Beule, D.
bioRxiv : 389437. 10 August 2018

Gadolinium deposition in the brain after contrast-enhanced MRI: are the data valid?
Boyken, J. and Niendorf, T. and Flemming, B. and Seeliger, E.
Radiology 288 (2): 630-632. 19 June 2018

Interpretation of functional renal MRI findings : where physiology and imaging sciences need to talk across domains.
Brix, S. and Cantow, K. and Flemming, B. and Pohlmann, A. and Niendorf, T. and Seeliger, E.
Journal of Magnetic Resonance Imaging 47 (4): 1140-1141. April 2018

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.
Bégay, V. and Baumeier, C. and Zimmermann, K. and Heuser, A. and Leutz, A.
Scientific Reports 8 (1): 8417. 30 May 2018

Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells.
Chen, P.Y. and Muzumdar, M.D. and Dorans, K.J. and Robbins, R.A. and Bhutkar, A. and Del Rosario, A.M. and Mertins, P. and Qiao, J. and Schaefer, C. and Gertler, F.B. and Carr, S.A. and Jacks, T.
Cancer Research 78 (4): 985-1002. 15 February 2018

Pervasive, coordinated protein-level changes driven by transcript isoform switching during meiosis.
Cheng, Z. and Otto, G.M. and Powers, E.N. and Keskin, A. and Mertins, P. and Carr, S.A. and Jovanovic, M. and Brar, G.A.
Cell 172 (5): 910-923. 22 February 2018

MetExplore: collaborative edition and exploration of metabolic networks.
Cottret, L. and Frainay, C. and Chazalviel, M. and Cabanettes, F. and Gloaguen, Y. and Camenen, E. and Merlet, B. and Heux, S. and Portais, J.C. and Poupin, N. and Vinson, F. and Jourdan, F.
Nucleic Acids Research 46 (W1): W495-W502. 2 July 2018

Acquisition and reconstruction of 4D surfaces of axolotl embryos with the flipping stage robotic microscope.
Crawford-Young, S.J. and Dittapongpitch, S. and Gordon, R. and Harrington, K.I.S.
Biosystems 173 : 214-220. November 2018

Artificial gene regulatory networks-a review.
Cussat-Blanc, S. and Harrington, K. and Banzhaf, W.
Artificial Life 24 (4): 296-328. 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z. and Daniel, B. and Horvath, A. and Rückerl, D. and Nagy, G. and Kiss, M. and Peloquin, M. and Budai, M.M. and Cuaranta-Monroy, I. and Simandi, Z. and Steiner, L. and Nagy, B. and Poliska, S. and Banko, C. and Bacso, Z. and Schulman, I.G. and Sauer, S. and Deleuze, J.F. and Allen, J.E. and Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

Extensive and functional overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte derived differentiating macrophages.
Czimmerer, Z. and Nagy, Z.S. and Nagy, G. and Horvath, A. and Silye-Cseh, T. and Kriston, A. and Jonas, D. and Sauer, S. and Steiner, L. and Daniel, B. and Deleuze, J.F. and Nagy, L.
Molecular and Cellular Endocrinology 471 : 63-74. 15 August 2018

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B. and Nagy, G. and Czimmerer, Z. and Horvath, A. and Hammers, D.W. and Cuaranta-Monroy, I. and Poliska, S. and Tzerpos, P. and Kolostyak, Z. and Hays, T.T. and Patsalos, A. and Houtman, R. and Sauer, S. and Francois-Deleuze, J. and Rastinejad, F. and Balint, B.L. and Sweeney, H.L. and Nagy, L.
Immunity 49 (4): 615-626. 16 October 2018

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B. and Nagy, G. and Horvath, A. and Czimmerer, Z. and Cuaranta-Monroy, I. and Poliska, S. and Hays, T.T. and Sauer, S. and Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46 (9): 4425-4439. 18 May 2018

Nuclear organization in the spinal cord depends on motor neuron lamination orchestrated by catenin and afadin function.
Dewitz, C. and Pimpinella, S. and Hackel, P. and Akalin, A. and Jessell, T.M. and Zampieri, N.
Cell Reports 22 (7): 1681-1694. 13 February 2018

On the relation between filament density, force generation and protrusion rate in mesenchymal cell motility.
Dolati, S. and Kage, F. and Mueller, J. and Müsken, M. and Kirchner, M. and Dittmar, G. and Sixt, M. and Rottner, K. and Falcke, M.
Molecular Biology of the Cell 29 (22): 2674-2686. 1 November 2018

S-palmitoylation is required for the control of growth cone morphology of DRG neurons by CNP-induced cGMP signaling.
Dumoulin, A. and Dagane, A. and Dittmar, G. and Rathjen, F.G.
Frontiers in Molecular Neuroscience 11 : 345. 24 September 2018

In vivo imaging of MMP-13 activity using a specific polymer-FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy.
Duro-Castano, A. and Lim, N.H. and Tranchant, I. and Amoura, M. and Beau, F. and Wieland, H. and Kingler, O. and Herrmann, M. and Nazaré, M. and Plettenburg, O. and Dive, V. and Vicent, M.J. and Nagase, H.
Advanced Functional Materials 28 (37): 1802738. 12 September 2018

Brain iron accumulation in Wilson's disease: a longitudinal imaging case study during anticopper treatment using 7.0T MRI and transcranial sonography.
Dusek, P. and Skoloudik, D. and Maskova, J. and Huelnhagen, T. and Bruha, R. and Zahorakova, D. and Niendorf, T. and Ruzicka, E. and Schneider, S.A. and Wuerfel, J.
Journal of Magnetic Resonance Imaging 47 (1): 282-285. January 2018

Silent witness: dual-species transcriptomics reveals epithelial immunological quiescence to helminth larval encounter and fostered larval development.
Ebner, F. and Kuhring, M. and Radonic, A. and Midha, A. and Renard, B.Y. and Hartmann, S.
Frontiers in Immunology 9 : 1868. 15 August 2018

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
Farsi, Z. and Gowrisankaran, S. and Krunic, M. and Rammner, B. and Woehler, A. and Lafer, E.M. and Mim, C. and Jahn, R. and Milosevic, I.
eLife 7 : e32569. 13 April 2018

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo.
Fecher, C. and Trovò, L. and Müller, S.A. and Snaidero, N. and Wettmarshausen, J. and Heink, S. and Ortiz, O. and Wagner, I. and Kühn, R. and Hartmann, J. and Karl, R.M. and Konnerth, A. and Korn, T. and Wurst, W. and Merkler, D. and Lichtenthaler, S.L. and Perocchi, F. and Misgeld, T.
bioRxiv : 403774. 29 August 2018

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations.
Fritsche-Guenther, R. and Zasada, C. and Mastrobuoni, G. and Royla, N. and Rainer, R. and Roßner, F. and Pietzke, M. and Klipp, E. and Sers, C. and Kempa, S.
Scientific Reports 8 (1): 9204. 15 June 2018

Near infrared spectroscopy setup for concurrent spectroscopic, invasive and MRI investigations in rats.
Gladytz, T. and Hoppe, A. and Cantow, K. and Brix, S. and Flemming, B. and Pohlmann, A. and Seeliger, E. and Niendorf, T. and Grosenick, D.
In: Clinical and Translational Biophotonics, 3-6 April 2018, Los Angeles, United States of Amerika. 2018

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Gross, A. and Pack, L.A.P. and Schacht, G.M. and Kant, S. and Ungewiss, H. and Meir, M. and Schlegel, N. and Preisinger, C. and Boor, P. and Guldiken, N. and Krusche, C.A. and Sellge, G. and Trautwein, C. and Waschke, J. and Heuser, A. and Leube, R.E. and Strnad, P.
Mucosal Immunology 11 (6): 1630-1639. 1 November 2018

An eicosanoid protects from statin-induced myopathic changes in primary human cells.
Grunwald, S.A. and Popp, O. and Haafke, S. and Jedraszczak, N. and Grieben, U. and Saar, K. and Patone, G. and Kress, W. and Steinhagen-Thiessen, E. and Dittmar, G. and Spuler, S.
bioRxiv : 271932. 26 February 2018

Transcriptional and translational differences of microglia from male and female brains.
Guneykaya, D. and Ivanov, A. and Perez Hernandez, D. and Haage, V. and Wojtas, B. and Meyer, N. and Maricos, M. and Jordan, P. and Buonfiglioli, A. and Gielniewski, B. and Ochocka, N. and Cömert, C. and Friedrich, C. and Suarez Artiles, L. and Kaminska, B. and Mertins, P. and Beule, D. and Kettenmann, H. and Wolf, S.A.
Cell Reports 24 (10): 2773-2783. 4 September 2018

Faecal microbiota composition associates with abdominal pain in the general population.
Hadizadeh, F. and Bonfiglio, F. and Belheouane, M. and Vallier, M. and Sauer, S. and Bang, C. and Bujanda, L. and Andreasson, A. and Agreus, L. and Engstrand, L. and Talley, N.J. and Rafter, J. and Baines, J.F. and Walter, S. and Franke, A. and D'Amato, M.
Gut 67 (4): 778-779. 8 March 2018

FunImageJ: a lisp framework for scientific image processing.
Harrington, K.I.S. and Rueden, C.T. and Eliceiri, K.W.
Bioinformatics 34 (5): 899-900. 1 March 2018

Preserved heart function after left ventricular pressure overload in adult mice subjected to neonatal cardiac hypoplasia.
Heinecke, K. and Heuser, A. and Blaschke, F. and Jux, C. and Thierfelder, L. and Drenckhahn, J.D.
Journal of Developmental Origins of Health and Disease 9 (1): 112-124. February 2018

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
Hernáez, B. and Alonso-Lobo, J.M. and Montanuy, I. and Fischer, C. and Sauer, S. and Sigal, L. and Sevilla, N. and Alcamí, A.
Nature Communications 9 (1): 5440. 21 December 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B. and Hermes, R. and Colleoni, S. and Diecke, S. and Holtze, S. and Renfree, M.B. and Stejskal, J. and Hayashi, K. and Drukker, M. and Loi, P. and Göritz, F. and Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

Multisite de novo mutations in human offspring after paternal exposure to ionizing radiation.
Holtgrewe, M. and Knaus, A. and Hildebrand, G. and Pantel, J.T. and de los Santos, M.R. and Neveling, K. and Goldmann, J. and Schubach, M. and Jäger, M. and Coutelier, M. and Mundlos, S. and Beule, D. and Sperling, K. and Krawitz, P.M.
Scientific Reports 8 (1): 14611. 2 October 2018

Myocardial effective transverse relaxation time T(2)* is elevated in hypertrophic cardiomyopathy: a 7.0 T magnetic resonance imaging study.
Huelnhagen, T. and Ku, M.C. and Reimann, H.M. and Serradas Duarte, T. and Pohlmann, A. and Flemming, B. and Seeliger, E. and Eichhorn, C. and Ferrari, V.A. and Prothmann, M. and Schulz-Menger, J. and Niendorf, T.
Scientific Reports 8 (1): 3974. 5 March 2018

Quantification of myocardial effective transverse relaxation time with magnetic resonance at 7.0 tesla for a better understanding of myocardial (patho)physiology.
Huelnhagen, T. and Serradas-Duarte, Teresa and Hezel, Fabian and Paul, K. and Niendorf, T.
In: Quantification of Biophysical Parameters in Medical Imaging. Springer, Cham, Switzerland, 343-372. ISBN 978-3-319-65923-7 2018

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: a comprehensive examination of the potential carriers for semiochemicals.
Iovinella, I. and McAfee, A. and Mastrobuoni, G. and Kempa, S. and Foster, L.J. and Pelosi, P. and Dani, F.R.
bioRxiv : 260539. 7 February 2018

Chromatin accessibility is dynamically regulated across C. elegans development and ageing.
Janes, J. and Dong, Y. and Schoof, M. and Serizay, J. and Appert, A. and Cerrato, C. and Woodbury, C. and Chen, R. and Gemma, C. and Huang, N. and Kissiov, D. and Stempor, P. and Steward, A. and Zeiser, E. and Sauer, S. and Ahringer, J.
bioRxiv : 279158. 10 June 2018

High peak and high average radiofrequency power transmit/receive switch for thermal magnetic resonance.
Ji, Y. and Hoffmann, W. and Pham, M. and Dunn, A.E. and Han, H. and Özerdem, C. and Waiczies, H. and Rohloff, M. and Endemann, B. and Boyer, C. and Lim, M. and Niendorf, T. and Winter, L.
Magnetic Resonance in Medicine 80 (5): 2246-2255. November 2018

Chromatin accessibility dynamics across C. elegans development and ageing.
Jänes, J. and Dong, Y. and Schoof, M. and Serizay, J. and Appert, A. and Cerrato, C. and Woodbury, C. and Chen, R. and Gemma, C. and Huang, N. and Kissiov, D. and Stempor, P. and Steward, A. and Zeiser, E. and Sauer, S. and Ahringer, J.
eLife 7 : e37344. 26 October 2018

PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn, J.D. and Miller, P.G. and Silver, A.J. and Sellar, R.S. and Bhatt, S. and Gibson, C. and McConkey, M. and Adams, D. and Mar, B. and Mertins, P. and Fereshetian, S. and Krug, K. and Zhu, H. and Letai, A. and Carr, S.A. and Doench, J. and Jaiswal, S. and Ebert, B.L.
Blood 132 (11): 1095-1105. 13 September 2018

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets via protocol-specific bias modeling.
Karabacak Calviello, A. and Hirsekorn, A. and Wurmus, R. and Yusuf, D. and Ohler, U.
bioRxiv : 284364. 19 March 2018

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim, M. and Wende, H. and Walcher, J. and Kühnemund, J. and Cheret, C. and Kempa, S. and McShane, E. and Selbach, M. and Lewin, G.R. and Birchmeier, C.
Genes & Development 32 (9-10): 645-657. 10 May 2018

Preanalytical processing and biobanking procedures of biological samples for metabolomics research: a white paper, community perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).
Kirwan, J.A. and Brennan, L. and Broadhurst, D. and Fiehn, O. and Cascante, M. and Dunn, W.B. and Schmidt, M.A. and Velagapudi, V.
Clinical Chemistry 64 (8): 1158-1182. August 2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
Klein, W. and Rutz, C. and Eckhard, J. and Provinciael, B. and Specker, E. and Neuenschwander, M. and Kleinau, G. and Scheerer, P. and von Kries, J.P. and Nazaré, M. and Vermeire, K. and Schülein, R.
PLoS ONE 13 (12): e0208641. 13 December 2018

FACT sets a barrier for cell fate reprogramming in Caenorhabditis elegans and human cells.
Kolundzic, E. and Ofenbauer, A. and Bulut, S.I. and Uyar, B. and Baytek, G. and Sommermeier, A. and Seelk, S. and He, M. and Hirsekorn, A. and Vucicevic, D. and Akalin, A. and Diecke, S. and Lacadie, S.A. and Tursun, B.
Developmental Cell 46 (5): 611-626. 10 September 2018

Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G. and Kim, Y. and de Almeida, P.E. and Termglinchan, V. and Diecke, S. and Shao, N.Y. and Wei, T.T. and Yi, H. and Dey, De. and Nelakanti, R. and Brouwer, T.P. and Paik, D.T. and Sagiv-Barfi, I. and Han, A. and Quax, P.H.A. and Hamming, J.F. and Levy, R. and Davis, M.M. and Wu, J.C.
Cell Stem Cell 22 (4): 501-513. 5 April 2018

Cardiac MRI in small animals.
Ku, M.C. and Huelnhagen, T. and Niendorf, T. and Pohlmann, A.
Methods in Molecular Biology 1718 : 269-284. 2018

Assessment of blood brain barrier leakage with gadolinium-enhanced MRI.
Ku, M.C. and Waiczies, S. and Niendorf, T. and Pohlmann, A.
Methods in Molecular Biology 1718 : 395-408. 2018

Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates.
Langer, H.T. and Senden, J.M.G. and Gijsen, A.P. and Kempa, S. and van Loon, Luc J. C. and Spuler, S.
Frontiers in Physiology 9 : 1220. 31 August 2018

The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.
Langhorst, H. and Jüttner, R. and Groneberg, D. and Mohtashamdolatshahi, A. and Pelz, L. and Purfürst, B. and Schmidt-Ott, K.M. and Friebe, A. and Rathjen, F.G.
Disease Models & Mechanisms 11 (2): dmm032128. 22 February 2018

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M. and Radke, M.H. and Eckhard, J. and Neuenschwander, M. and Dauksaite, V. and von Kries, J.P. and Gotthardt, M.
PLoS ONE 13 (6): e0198492. 11 June 2018

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.
Liu, Y. and Zhang, L. and Nazare, M. and Yao, Q. and Hu, H.Y.
Acta Pharmaceutica Sinica B 8 (3): 401-408. May 2018

Transient N-6-methyladenosine transcriptome sequencing reveals a regulatory role of m6A in splicing efficiency.
Louloupi, A. and Ntini, E. and Conrad, T. and Ørom, U.A.V.
Cell Reports 23 (12): 3429-3437. 19 June 2018

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.
Löber, U. and Hobbs, M. and Dayaram, A. and Tsangaras, K. and Jones, K. and Alquezar-Planas, D.E. and Ishida, Y. and Meers, J. and Mayer, J. and Quedenau, C. and Chen, W. and Johnson, R.N. and Timms, P. and Young, P.R. and Roca, A.L. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 115 (34): 8609-8614. 21 August 2018

SorCS2 controls functional expression of amino acid transporter EAAT3 to protect neurons from oxidative stress and epilepsy-induced pathology.
Malik, A.R. and Szydlowska, K. and Nizinska, K. and Asaro, A. and van Vliet, E.A. and Popp, O. and Dittmar, G. and Nykjaer, A. and Lukasiuk, K. and Aronica, E. and Willnow, T.E.
bioRxiv : 426734. 25 September 2018

Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
Matthes, F. and Hettich, M.M. and Schilling, J. and Flores-Dominguez, D. and Blank, N. and Wiglenda, T. and Buntru, A. and Wolf, H. and Weber, S. and Vorberg, I. and Dagane, A. and Dittmar, G. and Wanker, E. and Ehninger, D. and Krauss, S.
Cell Death Discovery 4 : 4. 29 January 2018

Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.
Mertins, P. and Tang, L.C. and Krug, K. and Clark, D.J. and Gritsenko, M.A. and Chen, L. and Clauser, K.R. and Clauss, T.R. and Shah, P. and Gillette, M.A. and Petyuk, V.A. and Thomas, S.N. and Mani, D.R. and Mundt, F. and Moore, R.J. and Hu, Y. and Zhao, R. and Schnaubelt, M. and Keshishian, H. and Monroe, M.E. and Zhang, Z. and Udeshi, N.D. and Mani, D. and Davies, S.R. and Townsend, R.R. and Chan, D.W. and Smith, R.D. and Zhang, H. and Liu, T. and Carr, S.A.
Nature Protocols 13 (7): 1632-1661. July 2018

Silencing the CSF-1 axis using nanoparticle encapsulated siRNA mitigates viral and autoimmune myocarditis.
Meyer, I.S. and Goetzke, C.C. and Kespohl, M. and Sauter, M. and Heuser, A. and Eckstein, V. and Vornlocher, H.P. and Anderson, D.G. and Haas, J. and Meder, B. and Katus, H.A. and Klingel, K. and Beling, A. and Leuschner, F.
Frontiers in Immunology 9 : 2303. 8 October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N. and Kolesnichenko, M. and Beaudette, P. and Popp, O. and Uyar, B. and Sun, W. and Tufan, A.B. and Perder, B. and Akalin, A. and Chen, W. and Mertins, P. and Dittmar, G. and Hinz, M. and Scheidereit, C.
EMBO Journal 37 (24): e98658. 14 December 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Mass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple-negative breast cancers.
Mundt, F. and Rajput, S. and Li, S. and Ruggles, K.V. and Mooradian, A.D. and Mertins, P. and Gillette, M.A. and Krug, K. and Guo, Z. and Hoog, J. and Erdmann-Gilmore, P. and Primeau, T. and Huang, S. and Edwards, D.P. and Wang, X. and Wang, X. and Kawaler, E. and Mani, D.R. and Clauser, K.R. and Gao, F. and Luo, J. and Davies, S.R. and Johnson, G.L. and Huang, K.L. and Yoon, C.J. and Ding, L. and Fenyö, D. and Ellis, M.J. and Townsend, R.R. and Held, J.M. and Carr, S.A. and Ma, C.X.
Cancer Research 78 (10): 2732-2746. May 2018

Emergence of robust nucleosome patterns from an interplay of positioning mechanisms.
Nuebler, J. and Wolff, M. and Obermayer, B. and Mobius, W. and Gerland, U.
bioRxiv : 431445. 1 October 2018

Validation of simulations in multiphase flow metrology by comparison with experimental video observations.
Olbrich, M. and Schmeyer, E. and Riazy, L. and Oberleithner, K. and Bär, M. and Schmelter, S.
Journal of Physics: Conference Series 1065 (9): 092015. 13 November 2018

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
Otten, C. and Knox, J. and Boulday, G. and Eymery, M. and Haniszewski, M. and Neuenschwander, M. and Radetzki, S. and Vogt, I. and Hähn, K. and De Luca, C. and Cardoso, C. and Hamad, S. and Igual Gil, C. and Roy, P. and Albiges‐Rizo, C. and Faurobert, E. and von Kries, J.P. and Campillos, M. and Tournier‐Lasserve, E. and Derry, W.B. and Abdelilah-Seyfried, S.
EMBO Molecular Medicine 10 (10): e9155. 1 October 2018

Multiband diffusion-weighted MRI of the eye and orbit free of geometric distortions using a RARE-EPI hybrid.
Paul, K. and Huelnhagen, T. and Oberacker, E. and Wenz, D. and Kuehne, A. and Waiczies, H. and Schmitter, S. and Stachs, O. and Niendorf, T.
NMR in Biomedicine 31 (3): e3872. March 2018

Isolation of native plasma membrane H(+)-ATPase (Pma1p) in both the active and basal activation states.
Pedersen, J.T. and Kanashova, T. and Dittmar, G. and Palmgren, M.
FEBS Open Bio 8 (5): 774-783. May 2018

FACS single cell index sorting is highly reliable and determines immune phenotypes of clonally expanded T cells.
Penter, L. and Dietze, K. and Bullinger, L. and Westermann, J. and Rahn, H.P. and Hansmann, L.
European Journal of Immunology 48 (7): 1248-1250. July 2018

De novo mutations implicate novel genes in systemic lupus erythematosus.
Pullabhatla, V. and Roberts, A.L. and Lewis, M.J. and Mauro, D. and Morris, D.L. and Odhams, C.A. and Tombleson, P. and Liljedahl, U. and Vyse, S. and Simpson, M.A. and Sauer, S. and de Rinaldis, E. and Syvänen, A.C. and Vyse, T.J.
Human Molecular Genetics 27 (3): 421-429. 1 February 2018

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
Rani James, A. and Schroeder, M.P. and Neumann, M. and Bastian, L. and Eckert, C. and Gökbuget, N. and Tanchez, J.O. and Schlee, C. and Isaakidis, K. and Schwartz, S. and Burmeister, T. and von Stackelberg, A. and Rieger, M.A. and Göllner, S. and Horstman, M. and Schrappe, M. and Kirschner-Schwabe, R. and Brüggemann, M. and Müller-Tidow, C. and Serve, H. and Akalin, A. and Baldus, C.D.
bioRxiv : 365429. 9 July 2018

Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Rausch, S. and Midha, A. and Kuhring, M. and Affinass, N. and Radonic, A. and Kühl, A.A. and Bleich, A. and Renard, B.Y. and Hartmann, S.
Frontiers in Immunology 9 : 2282. October 2018

Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix.
Reimann, H.M. and Todiras, M. and Hodge, Russ and Huelnhagen, T. and Millward, J.M. and Turner, R. and Seeliger, E. and Bader, M. and Pohlmann, A. and Niendorf, T.
NeuroImage 172 : 562-574. 15 May 2018

Human and equine endothelial cells in a live cell imaging scratch assay in vitro.
Rieger, J. and Hopperdietzel, C. and Kaessmeyer, S. and Slosarek, I. and Diecke, S. and Richardson, K. and Plendl, J.
Clinical Hemorheology and Microcirculation 70 (4): 495-509. 2018

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis.
Rohwer, N. and Jumpertz, S. and Erdem, M. and Egners, A. and Warzecha, K.T. and Fragoulis, A. and Kuehl, A.A. and Kramann, R. and Neuss, S. and Rudolph, I. and Endermann, T. and Zasada, C. and Apostolova, I. and Gerling, M. and Kempa, S. and Hughes, R. and Lewis, C.E. and Brenner, W. and Malinowski, M.B. and Stockmann, M. and Schomburg, L. and Faller, W. and Sansom, O.J. and Tacke, F. and Morkel, M. and Cramer, T.
bioRxiv : 273045. 28 February 2018

netSmooth: network-smoothing based imputation for single cell RNA-seq.
Ronen, J. and Akalin, A.
F1000Research 7 : 8. 10 July 2018

Evaluation of colorectal cancer subtypes and cell lines using deep learning.
Ronen, J. and Hayat, S. and Akalin, A.
bioRxiv : 464743. 12 November 2018

Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K. and Vogt, L. and Greber, B. and Diecke, S. and Boccaccini, A.R. and Scheibel, T. and Engel, F.B.
Advanced Functional Materials 28 (42): 1803951. October 2018

Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection.
Rother, M. and Gonzalez, E. and Teixeira da Costa, A.R. and Wask, L. and Gravenstein, I. and Pardo, M. and Pietzke, M. and Gurumurthy, R.K. and Angermann, J. and Laudeley, R. and Glage, S. and Meyer, M. and Chumduri, C. and Kempa, S. and Dinkel, K. and Unger, A. and Klebl, B. and Klos, A. and Meyer, T.F.
Cell Host & Microbe 23 (5): 661-671. 9 May 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
Salatzki, J. and Foryst-Ludwig, A. and Bentele, K. and Blumrich, A. and Smeir, E. and Ban, Z. and Brix, S. and Grune, J. and Beyhoff, N. and Klopfleisch, R. and Dunst, S. and Surma, M.A. and Klose, C. and Rothe, M. and Heinzel, F.R. and Krannich, A. and Kershaw, E.E. and Beule, D. and Schulze, P.C. and Marx, N. and Kintscher, U.
PLoS Genetics 14 (1): e1007171. 10 January 2018

Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons.
Schmidt, H. and Dickey, D.M. and Dumoulin, A. and Octave, M. and Robinson, J.W. and Kühn, R. and Feil, R. and Potter, L.R. and Rathjen, F.G.
Journal of Neuroscience 38 (45): 9768-9780. 7 November 2018

A general one-pot synthesis of 2H-indazoles using an organophosphorus-silane system.
Schoene, J. and Bel Abed, H. and Schmieder, P. and Christmann, M. and Nazaré, M.
Chemistry - A European Journal 24 (36): 9090-9100. 26 June 2018

CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Scholl, U.I. and Stölting, G. and Schewe, J. and Thiel, A. and Tan, H. and Nelson-Williams, C. and Vichot, A.A. and Jin, S.C. and Loring, E. and Untiet, V. and Yoo, T. and Choi, J. and Xu, S. and Wu, A. and Kirchner, M. and Mertins, P. and Rump, L.C. and Onder, A.M. and Gamble, C. and McKenney, D. and Lash, R.W. and Jones, D.P. and Chune, G. and Gagliardi, P. and Choi, M. and Gordon, R. and Stowasser, M. and Fahlke, C. and Lifton, R.P.
Nature Genetics 50 (3): 349-354. March 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K. and Tröger, J. and Eldahshan, A. and Zühlke, K. and Abdul Azeez, K.R. and Elkins, J.M. and Neuenschwander, M. and Oder, A. and Elkewedi, M.M.H. and Jaksch, S. and Andrae, K. and Li, J. and Fernandes, J. and Müller, P.M. and Grunwald, S. and Marino, S.F. and Vukićević, T. and Eichhorst, J. and Wiesner, B. and Weber, M. and Kapiloff, M. and Rocks, O. and Daumke, O. and Wieland, T. and Knapp, S. and von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M. and Klinger, B. and Klünemann, M. and Sieber, A. and Uhlitz, F. and Sauer, S. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J. and Mah, N. and Neuenschwander, M. and Kischka, T. and Ratei, R. and Schlag, P.M. and Castaños-Vélez, E. and Fichtner, I. and Tunn, P.U. and Denkert, C. and Klaas, O. and Berdel, W.E. and von Kries, J.P. and Makalowski, W. and Andrade-Navarro, M.A. and Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

CellFy: a cell-based fragment screen against C-type lectins.
Schulze, J. and Baukmann, H. and Wawrzinek, R. and Fuchsberger, F. and Specker, E.. and Aretz, J. and Nazaré, M. and Rademacher, C.
ACS Chemical Biology 13 (12): 3229-3235. December 2018

RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification.
Simandi, Z. and Horvath, A. and Cuaranta-Monroy, I. and Sauer, S. and Deleuze, J.F. and Nagy, L.
Molecular and Cellular Endocrinology 471 : 51-62. 15 August 2018

Future brain and spinal cord volumetric imaging in the clinic for monitoring treatment response in MS.
Sinnecker, T. and Granziera, C. and Wuerfel, J. and Schlaeger, R.
Current Treatment Options in Neurology 20 (6): 17. June 2018

Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions.
Sostare, J. and Di Guida, R. and Kirwan, J. and Chalal, K. and Palmer, E. and Dunn, W.B. and Viant, M.R.
Analytica Chimica Acta 1037 : 301-315. 11 December 2018

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
Subkhangulova, A. and Malik, A.R. and Hermey, G. and Popp, O. and Dittmar, G. and Rathjen, T. and Poy, M.N. and Stumpf, A. and Beed, P.S. and Schmitz, D. and Breiderhoff, T. and Willnow, T.E.
EMBO Reports 19 (4): e44810. 1 April 2018

Pervasive allele-specific regulation on RNA decay in hybrid mice.
Sun, W. and Gao, Q. and Schaefke, B. and Hu, Y. and Chen, W.
Life Science Alliance 1 (2): e201800052. May 2018

Loss of the hematopoietic stem cell factor GATA2 in the osteogenic lineage impairs trabecularization and mechanical strength of bone.
Tolkachov, A. and Fischer, C. and Ambrosi, T.H. and Bothe, M. and Han, C.T. and Muenzner, M. and Mathia, S. and Salminen, M. and Seifert, G. and Thiele, M. and Duda, G.N. and Meijsing, S.H. and Sauer, S. and Schulz, T.J. and Schupp, M.
Molecular and Cellular Biology 38 (12): e00599-17. June 2018

Identification and characterization of a single high-affinity fatty acid binding site in human serum albumin.
Wenskowsky, L. and Schreuder, H. and Derdau, V. and Matter, H. and Volkmar, J. and Nazaré, M. and Opatz, T. and Petry, S.
Angewandte Chemie International Edition 57 (4): 1044-1048. 22 January 2018

Millimeter spatial resolution in vivo sodium MRI of the human eye at 7 T using a dedicated radiofrequency transceiver array.
Wenz, D. and Kuehne, A. and Huelnhagen, T. and Nagel, A.M. and Waiczies, H. and Weinberger, O. and Oezerdem, C. and Stachs, O. and Langner, S. and Seeliger, E. and Flemming, B. and Hodge, R. and Niendorf, T.
Magnetic Resonance in Medicine 80 (2): 672-684. August 2018

Nitric oxide-sensitive guanylyl cyclase stimulation improves experimental heart failure with preserved ejection fraction.
Wilck, N. and Markó, L. and Balogh, A. and Kräker, K. and Herse, F. and Bartolomaeus, H. and Szijártó, I.A. and Gollasch, M. and Reichhart, N. and Strauss, O. and Heuser, A. and Brockschnieder, D. and Kretschmer, A. and Lesche, R. and Sohler, F. and Stasch, J.P. and Sandner, P. and Luft, F. and Müller, D.N. and Dechend, R. and Haase, N.
JCI Insight 3 (4): e96006. 22 February 2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S. and Zhou, J. and Liu, J.B. and Wu, Z. and Xu, X. and Li, T. and Xu, D. and Schumacher, S.E. and Puschhof, J. and McFarland, J. and Zou, C. and Dulak, A. and Henderson, L. and Xu, P. and O'Day, E. and Rendak, R. and Liao, W.L. and Cecchi, F. and Hembrough, T. and Schwartz, S. and Szeto, C. and Rustgi, A.K. and Wong, K.K. and Diehl, J.A. and Jensen, K. and Graziano, F. and Ruzzo, A. and Fereshetian, S. and Mertins, P. and Carr, S.A. and Beroukhim, R. and Nakamura, K. and Oki, E. and Watanabe, M. and Baba, H. and Imamura, Y. and Catenacci, D. and Bass, A.J.
Nature Medicine 24 (7): 968-977. July 2018

PiGx: reproducible genomics analysis pipelines with GNU Guix.
Wurmus, R. and Uyar, B. and Osberg, B. and Franke, V. and Gosdschan, A. and Wreczycka, K. and Ronen, J. and Akalin, A.
GigaScience 7 (12): giy123. 1 December 2018

Reproducible genomics analysis pipelines with GNU Guix.
Wurmus, R. and Uyar, B. and Osberg, B. and Franke, V. and Gosdschan, A. and Wreczycka, K. and Ronen, J. and Akalin, A.
bioRxiv : 298653. 21 April 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Picky: a simple online PRM and SRM method designer for targeted proteomics.
Zauber, H. and Kirchner, M. and Selbach, M.
Nature Methods 15 (3): 156-157. 28 February 2018

2017

Discovery of a novel series of tankyrase inhibitors by a hybridization approach.
Anumala, U.R. and Waaler, J. and Nkizinkiko, Y. and Ignatev, A. and Lazarow, K. and Lindemann, P. and Olsen, P.A. and Murthy, S. and Obaji, E. and Majouga, A.G. and Leonov, S. and von Kries, J.P. and Lehtiö, L. and Krauss, S. and Nazaré, M.
Journal of Medicinal Chemistry 60 (24): 10013-10025. 28 December 2017

Collagen cell carriers seeded with human urothelial cells for urethral reconstructive surgery: first results in a xenograft minipig model.
Aufderklamm, S. and Vaegler, M. and Kelp, A. and Maurer, S. and Gustafsson, L. and Mundhenk, J. and Busch, S. and Daum, L. and Stenzl, A. and Amend, B. and Sievert, K.D.
World Journal of Urology 35 (7): 1125-1132. July 2017

Enhanced precision and efficiency.
Bashir, S. and Kühn, R.
Nature Biomedical Engineering 1 (11): 856-857. November 2017

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.
Biagosch, C. and Ediga, R.D. and Hensler, S.V. and Faerberboeck, M. and Kuehn, R. and Wurst, W. and Meitinger, T. and Kölker, S. and Sauer, S. and Prokisch, H.
Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 (9): 2220-2228. September 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, M.R. and Simon, M.M. and Ingham, N.J. and Greenaway, S. and Santos, L. and Cater, H. and Taylor, S. and Mason, J. and Kurbatova, N. and Pearson, S. and Bower, L.R. and Clary, D.A. and Meziane, H. and Reilly, P. and Minowa, O. and Kelsey, L. and Tocchini-Valentini, G.P. and Gao, X. and Bradley, A. and Skarnes, W.C. and Moore, M. and Beaudet, A.L. and Justice, M.J. and Seavitt, J. and Dickinson, M.E. and Wurst, W. and Hrabe de Angelis, M. and Herault, Y. and Wakana, S. and Nutter, L.M.J. and Flenniken, A.M. and McKerlie, C. and Murray, S.A. and Svenson, K.L. and Braun, R.E. and West, D.B. and Lloyd, K.C.K. and Adams, D.J. and White, J. and Karp, N. and Flicek, P. and Smedley, D. and Meehan, T.F. and Parkinson, H.E. and Teboul, L.M. and Wells, S. and Steel, K.P. and Mallon, A.M. and Brown, S.D.M.
Nature Communications 8 (1): 886. 12 October 2017

Experimental validation of a preclinical SPECT/MR insert.
Carminati, M. and Occhipinti, M. and Baratelli, F. M. and Montagnani, G. L. and Nagy, K. and Nyitrai, Z. and Nagy, A. and Czeller, M. and Kühne, A. and Niendorf, T. and Mathe, D. and Belloli, S. and Valtorta, S. and Moresco, R. M. and Falini, A. and Iadanza, A. and Ottobrini, L. and Fiorini, C.
IEEE Nuclear Science Symposium and Medical Imaging Conference : 18264750. 2017

Identification of a novel benzimidazole pyrazolone scaffold that inhibits KDM4 lysine demethylases and reduces proliferation of prostate cancer cells.
Carter, D.M. and Specker, E. and Przygodda, J. and Neuenschwander, M. and von Kries, J.P. and Heinemann, U. and Nazaré, M. and Gohlke, U.
SLAS Discovery 22 (7): 801-812. 1 August 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N. and Naumann, H. and Ruzittu, S. and Mah, N. and Pongrac, I.M. and Cozzitorto, C. and Hommel, A. and Andrade-Navarro, M.A. and Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

Structural characterization and ligand/inhibitor identification provide functional insights into the mycobacterium tuberculosis cytochrome P450 CYP126A1.
Chenge, J.T. and Duyet, L.V. and Swami, S. and McLean, K.J. and Kavanagh, M.E. and Coyne, A.G. and Rigby, S.E.J. and Cheesman, M.R. and Girvan, H.M. and Levy, C.W. and Rupp, B. and von Kries, J.P. and Abell, C. and Leys, D. and Munro, A.W.
Journal of Biological Chemistry 292 (4): 1310-1329. 27 January 2017

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.
Churko, J.M. and Lee, J. and Ameen, M. and Gu, M. and Venkatasubramanian, M. and Diecke, S. and Sallam, K. and Im, H. and Wang, G. and Gold, J.D. and Salomonis, N. and Snyder, M.P. and Wu, J.C.
Nature Biomedical Engineering 1 (10): 826-837. October 2017

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.
Cui, H. and Bansal, V. and Grunert, M. and Malecova, B. and Dall Agnese, A. and Latella, L. and Gatto, S. and Ryan, T. and Schulz, K. and Chen, W. and Dorn, C. and Puri, P.L. and Sperling, S.R.
PLoS ONE 12 (6): e0179464. 13 June 2017

Control of gene editing by manipulation of DNA repair mechanisms.
Danner, E. and Bashir, S. and Yumlu, S. and Wurst, W. and Wefers, B. and Kühn, R.
Mammalian Genome 28 (7-8): 262-274. August 2017

Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery.
Dithmer, S. and Staat, C. and Müller, C. and Ku, M.C. and Pohlmann, A. and Niendorf, T. and Gehne, N. and Fallier-Becker, P. and Kittel, Á. and Walter, F.R. and Veszelka, S. and Deli, M.A. and Blasig, R. and Haseloff, R.F. and Blasig, I.E. and Winkler, L.
Annals of the New York Academy of Sciences 1397 (1): 169-184. June 2017

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ.
Dittmar, G. and Perez-Hernandez, D. and Kowenz-Leutz, E. and Kirchner, M. and Kahlert, G. and Wesolowski, R. and Baum, K. and Knoblich, M. and Muller, A. and Wolf, J. and Reimer, U. and Leutz, A.
bioRxiv : 238709. 22 December 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 5 January 2017

Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models.
Eduati, F. and Doldan-Martelli, V. and Klinger, B. and Cokelaer, T. and Sieber, A. and Kogera, F. and Dorel, M. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Cancer Research 77 (12): 3364-3375. 15 June 2017

Proton electrochemical gradient: driving and regulating neurotransmitter uptake.
Farsi, Z. and Jahn, R. and Woehler, A.
BioEssays 39 (5): 1600240. May 2017

Imaging activity-dependent signaling dynamics at the neuronal synapse using FRET-based biosensors.
Farsi, Z. and Woehler, A.
Methods in Molecular Biology 1538 : 261-275. 2017

RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation.
Ferrai, C. and Torlai Triglia, E. and Risner-Janiczek, J.R. and Rito, T. and Rackham, O.J.L. and De Santiago, I. and Kukalev, A. and Nicodemi, M. and Akalin, A. and Li, M. and Ungless, M.A. and Pombo, A.
Molecular Systems Biology 13 (10): 946. 16 October 2017

A chemical disruptor of the ClpX chaperone complex attenuates the virulence of multidrug-resistant Staphylococcus aureus.
Fetzer, C. and Korotkov, V.S. and Thänert, R. and Lee, K.M. and Neuenschwander, M. and von Kries, J.P. and Medina, E. and Sieber, S.A.
Angewandte Chemie International Edition 56 (49): 15746-15750. 4 December 2017

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf, I. and Litviňuková, M. and Schober, R. and Zayats, V. and Svobodova, B. and Bonhenry, D. and Lunz, V. and Cappello, S. and Tociu, L. and Reha, D. and Stallinger, A. and Hochreiter, A. and Pammer, T. and Butorac, C. and Muik, M. and Groschner, K. and Bogeski, I. and Ettrich, R.H. and Romanin, C. and Schindl, R.
Science Signaling 10 (507): eaao0358. 28 November 2017

Tissue optical properties from spatially resolved reflectance: calibration and in vivo application on rat kidney.
Gladytz, T. and Hoppe, A. and Cantow, K. and Flemming, B. and Pohlmann, A. and Niendorf, T. and Seeliger, E. and Grosenick, D.
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Reliable determination of tissue optical properties from spatially resolved reflectance.
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In: SPIE BiOS, 2017, San Francisco, California, United States. 14 March 2017

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
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Nucleic Acids Research 45 (W1): W560-W566. 3 July 2017

Protective function of Ahnak1 in vascular healing after wire injury.
Haase, N. and Rüder, C. and Haase, H. and Kamann, S. and Kouno, M. and Morano, I. and Dechend, R. and Zohlnhöfer, D. and Haase, T.
Journal of Vascular Research 54 (3): 131-142. May 2017

Open source 3D multipurpose measurement system with submillimetre fidelity and first application in magnetic resonance.
Han, H. and Moritz, R. and Oberacker, E. and Waiczies, H. and Niendorf, T. and Winter, L.
Scientific Reports 7 (1): 13452. 18 October 2017

RNA-seq based transcriptome analysis of the type I interferon host response upon vaccinia virus infection of mouse cells.
Hernáez, B. and Alonso, G. and Alonso-Lobo, J.M. and Rastrojo, A. and Fischer, C. and Sauer, S. and Aguado, B. and Alcamí, A.
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Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
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Nature Communications 8 : 15258. 31 May 2017

Small molecules targeting human N-acetylmannosamine kinase.
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ChemBioChem 18 (13): 1279-1285. 4 July 2017

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.
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Nature Communications 8 : 14864. 28 March 2017

Myocardial effective transverse relaxation time T(2)* correlates with left ventricular wall thickness: a 7.0 T MRI study.
Huelnhagen, T. and Hezel, F. and Serradas Duarte, T. and Pohlmann, A. and Oezerdem, C. and Flemming, B. and Seeliger, E. and Prothmann, M. and Schulz-Menger, J. and Niendorf, T.
Magnetic Resonance in Medicine 77 (6): 2381-2389. June 2017

Myocardial T(2)* mapping with ultrahigh field magnetic resonance: physics and frontier applications.
Huelnhagen, T. and Paul, K. and Ku, M.C. and Serradas Duarte, T. and Niendorf, T.
Frontiers in Physics 5 : 22. June 2017

INSERT: A novel clinical scanner for simultaneous SPECT/MRI brain studies.
Hutton, B.F. and Erlandsson, K. and Salvado, D. and Occhipinti, M. and Papp, Z. and Tolgyesi, B. and Willems, J. and Piemonte, C. and Carminati, M. and Bukki, T. and Legrady, G. and Kuehne, A. and Nyitrai, Z. and Niendorf, T. and Van Mullekom, P. and Waiczies, H. and Nagy, K. and De Francesco, I. and Mathe, D. and Ottobrini, L. and Short, S.C. and Fiorini, C.
IEEE Nuclear Science Symposium and Medical Imaging Conference : 18264611. 2017

Neuronal chemosensation and osmotic stress response converge in the regulation of aqp-8 in C. elegans.
Igual Gil, C. and Jarius, M. and von Kries, J.P. and Rohlfing, A.K.
Frontiers in Physiology 8 : 380. 9 June 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
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PLoS Biology 15 (6): e2000784. 1 June 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
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Nature 545 (7652): 98-102. 4 May 2017

A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I. and Termglinchan, V. and Cepeda, D.A. and Lee, J. and Diecke, S. and Hendel, A. and Itzhaki, I. and Ameen, M. and Shrestha, R. and Wu, H. and Ma, N. and Shao, N.Y. and Seeger, T. and Woo, N.A. and Wilson, K.D. and Matsa, E. and Porteus, M.H. and Sebastiano, V. and Wu, J.C.
Circulation Research 120 (10): 1561-1571. 12 May 2017

FACT sets a barrier for cell fate reprogramming in C. elegans and human.
Kolundzic, E. and Ofenbauer, A. and Uyar, B. and Sommermeier, A. and Seelk, S. and He, M. and Baytek, G. and Akalin, A. and Diecke, S. and Lacadie, S.A. and Tursun, B.
bioRxiv : 185116. 6 September 2017

Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p.
Laub, K.R. and Marek, M. and Stanchev, L.D. and Herrera, S.A. and Kanashova, T. and Bourmaud, A. and Dittmar, G. and Guenther Pomorski, T.
PLoS ONE 12 (9): e0184236. 18 September 2017

Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.
Lin, L. and Petersen, T.S. and Jensen, K.T. and Bolund, L. and Kühn, R. and Luo, Y.
Journal of Biotechnology 247 : 42-49. 10 April 2017

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
Lutter, D. and Ullrich, F. and Lueck, J.C. and Kempa, S. and Jentsch, T.J.
Journal of Cell Science 130 (6): 1122-1133. 15 March 2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S. and Childs, L.H. and Aust, D. and Heim, D. and Melching, F. and Oliveira, C. and Wolf, T. and Durek, P. and Schumacher, D. and Blaeker, H. and von Winterfeld, M. and Gastl, B. and Moehr, K. and Menne, A. and Zeugner, S. and Redmer, T. and Lenze, D. and Tierling, S. and Moebs, M. and Weichert, W. and Folprecht, G. and Blanc, E. and Beule, D. and Schaefer, R. and Morkel, M. and Klauschen, F. and Leser, U. and Sers, C.
Nature Communications 8 : 14093. 25 January 2017

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
Martinez, A. and Lectez, B. and Ramirez, J. and Popp, O. and Sutherland, J.D. and Urbe, S. and Dittmar, G. and Clague, M.J. and Mayor, U.
Molecular Neurodegeneration 12 (1): 29. 11 April 2017

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.
Mattei, D. and Ivanov, A. and Ferrai, C. and Jordan, P. and Guneykaya, D. and Buonfiglioli, A. and Schaafsma, W. and Przanowski, P. and Deuther-Conrad, W. and Brust, P. and Hesse, S. and Patt, M. and Sabri, O. and Ross, T.L. and Eggen, B.J.L. and Boddeke, E.W.G.M. and Kaminska, B. and Beule, D. and Pombo, A. and Kettenmann, H. and Wolf, S.A.
Translational Psychiatry 7 (5): e1120. 9 May 2017

An integrative framework reveals signaling-to-transcription events in toll-like receptor signaling.
Mertins, P. and Przybylski, D. and Yosef, N. and Qiao, J. and Clauser, K. and Raychowdhury, R. and Eisenhaure, T.M. and Maritzen, T. and Haucke, V. and Satoh, T. and Akira, S. and Carr, S.A. and Regev, A. and Hacohen, N. and Chevrier, N.
Cell Reports 19 (13): 2853-2866. 27 June 2017

HLA-MA: simple yet powerful matching of samples using HLA typing results.
Messerschmidt, C. and Holtgrewe, M. and Beule, D.
Bioinformatics 33 (14): 2241-2242. 15 July 2017

Degrons in cancer.
Meszaros, B. and Kumar, M. and Gibson, T.J. and Uyar, B. and Dosztanyi, Z.
Science Signaling 10 (470): eaak9982. 14 March 2017

Mutations in disordered regions cause disease by creating endocytosis motifs.
Meyer, K. and Uyar, B. and Kirchner, M. and Cheng, J. and Akalin, A. and Selbach, M.
bioRxiv : 141622. 24 May 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F. and Rapp, A. and Yu, W. and Maiser, A. and Harz, H. and Scholl, A. and Grulich, S. and Anton, T. and Hoerl, D. and Chen, W. and Durante, M. and Taucher-Scholz, G. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

Radiative RF antenna arrays for cardiac, brain and thermal magnetic resonance at ultrahigh and extreme magnetic field strengths: Concepts, electromagnetic field simulations and applications.
Niendorf, T. and Oezerdem, C. and Ji, Y. and Oberacker, E. and Kuehne, A. and Waiczies, H. and Winter, L.
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Low-field cardiac magnetic resonance imaging a compelling case for cardiac magnetic resonance's future response.
Niendorf, T. and Schulz-Menger, J. and Paul, K. and Huelnhagen, T. and Ferrari, V.A. and Hodge, R.
Circulation Cardiovascular Imaging 10 (6): e005446 (7). 13 June 2017

High field cardiac magnetic resonance imaging: a case for ultrahigh field cardiac magnetic resonance.
Niendorf, T. and Schulz-Menger, J. and Paul, K. and Huelnhagen, T. and Ferrari, V.A. and Hodge, R.
Circulation Cardiovascular Imaging 10 (6): e005460. June 2017

Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme: a 298 MHz(7.0 Tesla) thermal magnetic resonancesimulation study.
Oberacker, E. and Kuehne, A. and Nadobny, J. and Zschaeck, S. and Weihrauch, M. and Waiczies, H. and Ghadjar, P. and Wust, P. and Niendorf, T. and Winter, L.
Current Directions in Biomedical Engineering 3 (2): 473-477. September 2017

Magnetic resonance safety and compatibility of tantalum markers used in proton beam therapy for intraocular tumors: a 7.0 Tesla study.
Oberacker, E. and Paul, K. and Huelnhagen, T. and Oezerdem, C. and Winter, L. and Pohlmann, A. and Boehmert, L. and Stachs, O. and Heufelder, J. and Weber, A. and Rehak, M. and Seibel, I. and Niendorf, T.
Magnetic Resonance in Medicine 78 (4): 1533-1546. October 2017

INSERT Project: First results of a MR compatible preclinical SPECT based on SiPM photodetectors.
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Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J. and Menzel, L. and Niesler, N. and Kobelt, D. and Aumann, J. and Rivera, M. and Walther, W.
BMC Cancer 17 (1): 129. 13 February 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

The cell adhesion molecule BT-IgSF is essential for a functional blood-testis barrier and male fertility in mice.
Pelz, L. and Purfürst, B. and Rathjen, F.G.
Journal of Biological Chemistry 292 (52): 21490-21503. 29 December 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Experimental MRI monitoring of renal blood volume fraction variations en route to renal magnetic resonance oximetry.
Pohlmann, A. and Cantow, K. and Huelnhagen, T. and Grosenick, D. and dos Santos Periquito, J. and Boehmert, L. and Gladytz, T. and Waiczies, S. and Flemming, B. and Seeliger, E. and Niendorf, T.
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De novo mutations implicate novel genes with burden of rare variants in systemic lupus erythematosus.
Pullabhatla, V. and Roberts, A.L. and Lewis, M.J. and Mauro, D. and Morris, D.L. and Odhams, C.A. and Tombleson, P. and Liljedahld, U. and Vyse, S. and Simpson, M.A. and Sauer, S. and de Rinaldis, E. and Syvaenen, A.C. and Vyse, T.J.
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Tissue specific labeling in proteomics.
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Proteomes 5 (3): E17. 18 July 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
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Nature Neuroscience 20 (8): 1096-1103. August 2017

Initiation of acute graft-versus-host disease by angiogenesis.
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Blood 129 (14): 2021-2032. 6 April 2017

netSmooth: Network-smoothing based imputation for single cell RNA-seq.
Ronen, J. and Akalin, A.
bioRxiv : 234021. 13 December 2017

The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance.
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Molecular & Cellular Oncology 4 (4): e1338209. 5 July 2017

Health-beneficial nutraceuticals - myth or reality?
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Applied Microbiology and Biotechnology 101 (3): 951-961. February 2017

A straightforward approach to N-substituted-2 H-indazol-2-amines through reductive cyclization.
Schoene, J. and Bel Abed, H. and Christmann, M. and Nazare, M.
Tetrahedron Letters 58 (16): 1633-1635. 19 April 2017

Direct experimental evidence for halogen-aryl π interactions in solution from molecular torsion balances.
Sun, H. and Horatscheck, A. and Martos, V. and Bartetzko, M. and Uhrig, U. and Lentz, D. and Schmieder, P. and Nazaré, M.
Angewandte Chemie International Edition 56 (23): 6454-6458. 1 June 2017

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
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Nature Neuroscience 20 (6): 793-803. June 2017

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Tobe, B.T.D. and Crain, A.M. and Winquist, A.M. and Calabrese, B. and Makihara, H. and Zhao, W.N. and Lalonde, J. and Nakamura, H. and Konopaske, G. and Sidor, M. and Pernia, C.D. and Yamashita, N. and Wada, M. and Inoue, Y. and Nakamura, F. and Sheridan, S.D. and Logan, R.W. and Brandel, M. and Wu, D. and Hunsberger, J. and Dorsett, L. and Duerr, C. and Basa, R.C.B. and McCarthy, M.J. and Udeshi, N.D. and Mertins, P. and Carr, S.A. and Rouleau, G.A. and Mastrangelo, L. and Li, J. and Gutierrez, G.J. and Brill, L.M. and Venizelos, N. and Chen, G. and Nye, J.S. and Manji, H. and Price, J.H. and McClung, C.A. and Akiskal, H.S. and Alda, M. and Chuang, D.M.M. and Coyle, J.T. and Liu, Y. and Teng, Y.D. and Ohshima, T. and Mikoshiba, K. and Sidman, R.L. and Halpain, S. and Haggarty, S.J. and Goshima, Y. and Snyder, E.Y.
Proceedings of the National Academy of Sciences of the United States of America 114 (22): E4462-E4471. 30 May 2017

Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1.
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Journal of Cell Biology 216 (12): 4255. 4 December 2017

RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Uyar, B. and Yusuf, D. and Wurmus, R. and Rajewsky, N. and Ohler, U. and Akalin, A.
Nucleic Acids Research 45 (10): e91. 2 June 2017

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
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Nature 546 (7657): 302-306. 8 June 2017

A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells.
Velasco, S. and Ibrahim, M.M. and Kakumanu, A. and Garipler, G. and Aydin, B. and Al-Sayegh, M.A. and Hirsekorn, A. and Abdul-Rahman, F. and Satija, R. and Ohler, U. and Mahony, S. and Mazzoni, E.O.
Cell Stem Cell 20 (2): 205-217. 2 February 2017

Enhanced fluorine-19 MRI sensitivity using a cryogenic radiofrequency probe: technical developments and ex vivo demonstration in a mouse model of neuroinflammation.
Waiczies, S. and Millward, J.M. and Starke, L. and Delgado, P.R. and Huelnhagen, T. and Prinz, C. and Marek, D. and Wecker, D. and Wissmann, R. and Koch, S.P. and Boehm-Sturm, P. and Waiczies, H. and Niendorf, T. and Pohlmann, A.
Scientific Reports 7 (1): 9808. 29 August 2017

Labeling of cell therapies: How can we get it right?
Waiczies, S. and Niendorf, T. and Lombardi, G.
OncoImmunology 6 (10): e1345403. 20 July 2017

Proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction.
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Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Wefers, B. and Bashir, S. and Rossius, J. and Kühn, R.
Methods 121-122 : 55-67. 15 May 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C. and Pifferi, S. and Picci, C. and Gök, C. and Hoffmann, D. and Bali, K.K. and Lampe, A. and Lapatsina, L. and Fleischer, R. and Smith, E.S.J. and Bégay, V. and Moroni, M. and Estebanez, L. and Kühnemund, J. and Walcher, J. and Specker, E. and Neuenschwander, M. and von Kries, J.P. and Haucke, V. and Kuner, R. and Poulet, J.F.A. and Schmoranzer, J. and Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

Salt-responsive gut commensal modulates T(H)17 axis and disease.
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Nature 551 (7682): 585-589. 30 November 2017

HOT or not: Examining the basis of high-occupancy target regions.
Wreczycka, K. and Franke, V. and Uyar, B. and Wurmus, R. and Akalin, A.
bioRxiv : 107680. 31 July 2017

Strategies for analyzing bisulfite sequencing data.
Wreczycka, K. and Gosdschan, A. and Yusuf, D. and Gruening, B. and Assenov, Y. and Akalin, A.
bioRxiv : 109512. 9 August 2017

Strategies for analyzing bisulfite sequencing data.
Wreczycka, K. and Gosdschan, A. and Yusuf, D. and Grüning, B. and Assenov, Y. and Akalin, A.
Journal of Biotechnology 261 : 105-115. 10 November 2017

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E. and Menegatti, J. and Franke, V. and Kocks, C. and Boltengagen, A. and Hennig, T. and Theil, K. and Rutkowski, A. and Ferrai, C. and Baer, L. and Kermas, L. and Friedel, C. and Rajewsky, N. and Akalin, A. and Dölken, L. and Grässer, F. and Landthaler, M.
Genome Biology 18 (1): 209. 31 October 2017

Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.
Xu, X. and Meng, Q. and Erben, U. and Wang, P. and Glauben, R. and Kuehl, A.A. and Wu, H. and Ma, C.W. and Hu, M. and Wang, Y. and Sun, W. and Jia, J. and Wu, X. and Chen, W. and Siegmund, B. and Qin, Z.
Cellular and Molecular Immunology 14 (7): 597-606. July 2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A. and van den Bruck, D. and Ciolli Mattioli, C. and Franke, V. and Imami, K. and McShane, E. and Moreno-Estelles, M. and Calviello, L. and Filipchyk, A. and Peguero-Sanchez, E. and Müller, T. and Woehler, A. and Birchmeier, C. and Merino, E. and Rajewsky, N. and Ohler, U. and Mazzoni, E.O. and Selbach, M. and Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

Guidelines on severity assessment and classification of genetically altered mouse and rat lines.
Zintzsch, A. and Noe, E. and Reissmann, M. and Ullmann, K. and Kraemer, S. and Jerchow, B. and Kluge, R. and Goesele, C. and Nickles, H. and Puppe, A. and Ruelicke, T.
Laboratory Animals 51 (6): 573-582. 1 December 2017

Synthesis of europium-doped VSOP, customized enhancer solution and improved microscopy fluorescence methodology for unambiguous histological detection.
de Schellenberger, A.A. and Hauptmann, R. and Millward, J.M. and Schellenberger, E. and Kobayashi, Y. and Taupitz, M. and Infante-Duarte, C. and Schnorr, J. and Wagner, S.
Journal of Nanobiotechnology 15 (1): 71. 10 October 2017

2016

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases.

Nucleic Acids Research 44 (D1): D27-D37. 4 January 2016

Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same.
Max-Delbrück-Centrum für Molekulare Medizin.
WO/2016/135199. 1 September 2016

Proteomic techniques to probe the ubiquitin landscape.
Beaudette, P. and Popp, O. and Dittmar, G.
Proteomics 16 (2): 273-287. January 2016

Metabolomics enables precision medicine: "A White Paper, Community Perspective".
Beger, R.D. and Dunn, W. and Schmidt, M.A. and Gross, S.S. and Kirwan, J.A. and Cascante, M. and Brennan, L. and Wishart, D.S. and Oresic, M. and Hankemeier, T. and Broadhurst, D.I. and Lane, A.N. and Suhre, K. and Kastenmüller, G. and Sumner, S.J. and Thiele, I. and Fiehn, O. and Kaddurah-Daouk, R.
Metabolomics 12 (9): 149. September 2016

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles.
Bel Abed, H. and Schoene, J. and Christmann, M. and Nazare, M.
Organic & Biomolecular Chemistry 14 (36): 8520-8528. 28 September 2016

Proteomics quality control : a quality control software for MaxQuant results.
Bielow, C. and Mastrobuoni, G. and Kempa, S.
Journal of Proteome Research 15 (3): 777-787. 4 March 2016

Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI.
Blaabjerg, M. and Ruprecht, K. and Sinnecker, T. and Kondziella, D. and Niendorf, T. and Kerrn-Jespersen, B.M. and Lindelof, M. and Lassmann, H. and Kristensen, B.W. and Paul, F. and Illes, Z.
Neurology Neuroimmunology & Neuroinflammation 3 (3): e226. June 2016

ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss.
Brachs, M. and Wiegand, S. and Leupelt, V. and Ernert, A. and Kintscher, U. and Jumpertz von Schwarzenberg, R. and Decker, A.M. and Bobbert, T. and Hübner, N. and Chen, W. and Krude, H. and Spranger, J. and Mai, K.
Metabolism 65 (6): 935-943. June 2016

Circular RNAs in brain and other tissues: a functional enigma.
Chen, W. and Schuman, E.
Trends in Neurosciences 39 (9): 597-604. September 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T. and Graf, R. and Wirtz, T. and Weber, T. and Favret, J. and Li, X. and Petsch, K. and Tran, N.T. and Sieweke, M.H. and Berek, C. and Kühn, R. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519. 1 November 2016

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.
Chu, V.T. and Weber, T. and Graf, R. and Sommermann, T. and Petsch, K. and Sack, U. and Volchkov, P. and Rajewsky, K. and Kühn, R.
BMC Biotechnology 16 (1): 4. 16 January 2016

Serial interactome capture of the human cell nucleus.
Conrad, T. and Albrecht, A.-S. and Rodrigues de Melo Costa, V. and Sauer, S. and Meierhofer, D. and Ørom, U.A.
Nature Communications 7 : 11212. 4 April 2016

Asymmetric division coordinates collective cell migration in angiogenesis.
Costa, G. and Harrington, K.I. and Lovegrove, H.E. and Page, D.J. and Chakravartula, S. and Bentley, K. and Herbert, S.P.
Nature Cell Biology 18 (12): 1292-1301. December 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

Characterization of a single genomic locus encoding the clustered protocadherin receptor diversity in Xenopus tropicalis.
Etlioglu, H.E. and Sun, W. and Huang, Z. and Chen, W. and Schmucker, D.
G3 : Genes Genomes Genetics 6 (8): 2309-2318. 1 August 2016

Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles.
Farsi, Z. and Preobraschenski, J. and van den Bogaart, G. and Riedel, D. and Jahn, R. and Woehler, A.
Science 351 (6276): 981-984. 26 February 2016

Advanced light microscopy core facilities: Balancing service, science and career.
Ferrando-May, E. and Hartmann, H. and Reymann, J. and Ansari, N. and Utz, N. and Fried, H.U. and Kukat, C. and Peychl, J. and Liebig, C. and Terjung, S. and Laketa, V. and Sporbert, A. and Weidtkamp-Peters, S. and Schauss, A. and Zuschratter, W. and Avilov, S.
Microscopy Research and Technique 79 (6): 463-479. June 2016

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.
Fritsche-Guenther, R. and Witzel, F. and Kempa, S. and Brummer, T. and Sers, C. and Blüthgen, N.
Oncotarget 7 (7): 7960-7969. 20 January 2016

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. and Ammar, I. and Gupta, S. and Bunse, M. and Miskey, C. and Chen, W. and Uckert, W. and Schulz, T.F. and Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.
Grunert, M. and Dorn, C. and Cui, H. and Dunkel, I. and Schulz, K. and Schoenhals, S. and Sun, W. and Berger, F. and Chen, W. and Sperling, S.R.
Cardiovascular Research 112 (1): 464-477. 1 October 2016

A circuit basis for morphogenesis.
Harrington, K.I.S.
Theoretical Computer Science 633 : 28-36. 20 June 2016

Mass spectrometry based metabolomics comparison of liver grafts from donors after circulatory death (DCD) and donors after brain death (DBD) used in human orthotopic liver transplantation.
Hrydziuszko, O. and Perera, M.T.P.R. and Laing, R. and Kirwan, J. and Silva, M.A. and Richards, D.A. and Murphy, N. and Mirza, D.F. and Viant, M.R.
PLoS ONE 11 (11): e0165884. 11 November 2016

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H. and Haas, S.A. and Chelly, J. and Van Esch, H. and Raynaud, M. and de Brouwer, A.P.M. and Weinert, S. and Froyen, G. and Frints, S.G.M. and Laumonnier, F. and Zemojtel, T. and Love, M.I. and Richard, H. and Emde, A.K. and Bienek, M. and Jensen, C. and Hambrock, M. and Fischer, U. and Langnick, C. and Feldkamp, M. and Wissink-Lindhout, W. and Lebrun, N. and Castelnau, L. and Rucci, J. and Montjean, R. and Dorseuil, O. and Billuart, P. and Stuhlmann, T. and Shaw, M. and Corbett, M.A. and Gardner, A. and Willis-Owen, S. and Tan, C. and Friend, K.L. and Belet, S. and van Roozendaal, K.E.P. and Jimenez-Pocquet, M. and Moizard, M.P. and Ronce, N. and Sun, R. and O'Keeffe, S. and Chenna, R. and van Bömmel, A. and Goeke, J. and Hackett, A. and Field, M. and Christie, L. and Boyle, J. and Haan, E. and Nelson, J. and Turner, G. and Baynam, G. and Gillessen-Kaesbach, G. and Mueller, U. and Steinberger, D. and Budny, B. and Badura-Stronka, M. and Latos-Bieleńska, A. and Ousager, L.B. and Wieacker, P. and Rodríguez Criado, G. and Bondeson, M.L. and Annerén, G. and Dufke, A. and Cohen, M. and Van Maldergem, L. and Vincent-Delorme, C. and Echenne, B. and Simon-Bouy, B. and Kleefstra, T. and Willemsen, M. and Fryns, J.P. and Devriendt, K. and Ullmann, R. and Vingron, M. and Wrogemann, K. and Wienker, T.F. and Tzschach, A. and van Bokhoven, H. and Gecz, J. and Jentsch, T.J. and Chen, W. and Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21 (1): 133-148. January 2016

Activation of peroxisome proliferator-activated receptor-δ as novel therapeutic strategy to prevent in-stent restenosis and stent thrombosis.
Hytönen, J. and Leppänen, O. and Braesen, J.H. and Schunck, W.H. and Mueller, D. and Jung, F. and Mrowietz, C. and Jastroch, M. and von Bergwelt-Baildon, M. and Kappert, K. and Heuser, A. and Drenckhahn, J.D. and Pieske, B. and Thierfelder, L. and Ylä-Herttuala, S. and Blaschke, F.
Arteriosclerosis Thrombosis and Vascular Biology 36 (8): 1534-1548. August 2016

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions.
Jargosch, M. and Kroeger, S. and Gralinska, E. and Klotz, U. and Fang, Z. and Chen, W. and Leser, U. and Selbig, J. and Groth, D. and Baumgrass, R.
Genetics and Molecular Research 15 (2): gmr.15028493. 24 June 2016

Genome wide conditional mouse knockout resources.
Kaloff, C. and Anastassiadis, K. and Ayadi, A. and Baldock, R. and Beig, J. and Birling, M.C. and Bradley, A. and Brown, S.D.M. and Buerger, A. and Bushell, W. and Chiani, F. and Collins, F.S. and Doe, B. and Eppig, J.T. and Finnell, R.H. and Fletcher, C. and Flicek, P. and Fray, M. and Friedel, R.H. and Gambadoro, A. and Gates, H. and Hansen, J. and Herault, Y. and Hicks, G.G. and Hoerlein, A. and Hrabe de Angelis, M. and Iyer, V. and de Jong, P.J. and Koscielny, G. and Kuehn, R. and Liu, P. and Lloyd, K.C.K and Lopez, R.G. and Marschall, S. and Martinez, S. and McKerlie, C. and Meehan, T. and von Melchner, H. and Moore, M. and Murray, S.A. and Nagy, A. and Nutter, L.M.J. and Pavlovic, G. and Pombero, A. and Prosser, H. and Ramirez-Solis, R. and Ringwald, M. and Rosen, B. and Rosenthal, N. and Rossant, J. and Ruiz Noppinger, P. and Ryder, E. and Skarnes, W.C. and Schick, J. and Schnuetgen, F. and Schofield, P. and Seisenberger, C. and Selloum, M. and Smedley, D. and Simpson, E.M. and Stewart, A.F. and Teboul, L. and Tocchini Valentini, G.P. and Valenzuela, D. and West, A.P. and Wurst, W.
Drug Discovery Today: Disease Models 20 : 3-12. 2016

SPIRE, a modular pipeline for eQTL analysis of RNA-Seq data, reveals a regulatory hotspot controlling miRNA expression in C. elegans.
Kel, I. and Chang, Z. and Galluccio, N. and Romeo, M. and Beretta, S. and Diomede, L. and Mezzelani, A. and Milanesi, L. and Dieterich, C. and Merelli, I.
Molecular BioSystems 12 (11): 3447-3458. 1 November 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S. and Helmuth, J. and Polansky, J.K. and Dunkel, I. and Gasparoni, G. and Froehler, S. and Chen, W. and Walter, J. and Hamann, A. and Chung, H.R.
Nature Communications 7 : 12514. 17 August 2016

Genetic causes of MCPH in consanguineous Pakistani families.
Kraemer, N. and Picker-Minh, S. and Abbasi, A.A. and Froehler, S. and Ninnemann, O. and Khan, M.N. and Ali, G. and Chen, W. and Kaindl, A.M.
Clinical Genetics 89 (6): 744-745. June 2016

Bi-allelic truncating mutations in TANGO2 cause infancy-onset recurrent metabolic crises with encephalocardiomyopathy.
Kremer, L.S. and Distelmaier, F. and Alhaddad, B. and Hempel, M. and Iuso, A. and Küpper, C. and Mühlhausen, C. and Kovacs-Nagy, R. and Satanovskij, R. and Graf, E. and Berutti, R. and Eckstein, G. and Durbin, R. and Sauer, S. and Hoffmann, G.F. and Strom, T.M. and Santer, R. and Meitinger, T. and Klopstock, T. and Prokisch, H. and Haack, T.B.
American Journal of Human Genetics 98 (2): 358-362. 4 February 2016

ERK1 as a therapeutic target for dendritic cell vaccination against high-grade gliomas.
Ku, M.C. and Edes, I. and Bendix, I. and Pohlmann, A. and Waiczies, H. and Prozorovski, T. and Günther, M. and Martin, C. and Pagès, G. and Wolf, S.A. and Kettenmann, H. and Uckert, W. and Niendorf, T. and Waiczies, S.
Molecular Cancer Therapeutics 15 (8): 1975-1987. August 2016

TALENs : Methods and Protocols.
Kuehn, R. and Wurst, W. and Wefers, B.
Methods in Molecular Biology, 1338 . Springer, New York. ISBN 978-1-4939-2931-3 2016

Temporal modulation of collective cell behavior controls vascular network topology.
Kur, E. and Kim, J. and Tata, A. and Comin, C.H. and Harrington, K.I. and Costa, L.d.F. and Bentley, K. and Gu, C.
eLife 5 : e13212. 24 February 2016

Generation of functional cardiomyocytes from the synoviocytes of patients with rheumatoid arthritis via induced pluripotent stem cells.
Lee, J. and Jung, S.M. and Ebert, A.D. and Wu, H. and Diecke, S. and Kim, Y. and Yi, H. and Park, S.H. and Ju, J.H.
Scientific Reports 6 : 32669. 9 September 2016

Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling.
Limbach, M. and Saare, M. and Tserel, L. and Kisand, K. and Eglit, T. and Sauer, S. and Axelsson, T. and Syvänen, A.C. and Metspalu, A. and Milani, L. and Peterson, P.
Journal of Autoimmunity 67 : 46-56. February 2016

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D. and Pahuja, A. and Geers-Knörr, C. and Scheibe, R. and Nowak, M. and Hamati, J. and Köhncke, C. and Purfürst, B. and Kanashova, T. and Schmidt, S. and Glass, D.J. and Morano, I. and Heuser, A. and Kraft, T. and Bassel-Duby, R. and Olson, E.N. and Dittmar, G. and Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180. May 2016

Identification of novel genetic causes of Rett syndrome-like phenotypes.
Lopes, F. and Barbosa, M. and Ameur, A. and Soares, G. and de Sá, J. and Dias, A.I. and Oliveira, G. and Cabral, P. and Temudo, T. and Calado, E. and Cruz, I.F. and Vieira, J.P. and Oliveira, R. and Esteves, S. and Sauer, S. and Jonasson, I. and Syvänen, A.C. and Gyllensten, U. and Pinto, D. and Maciel, P.
Journal of Medical Genetics 53 (3): 190-199. March 2016

Efficient application of de novo RNA assemblers for proteomics informed by transcriptomics.
Luge, T. and Fischer, C. and Sauer, S.
Journal of Proteome Research 15 (10): 3938-3943. 7 October 2016

Generating sample-specific databases for mass spectrometry-based proteomic analysis by using RNA sequencing.
Luge, T. and Sauer, S.
Methods in Molecular Biology 1394 : 219-232. 2016

A novel splicing mutation in the IQSEC2 gene that modulates the phenotype severity in a family with intellectual disability.
Madrigal, I. and Alvarez-Mora, M.I. and Rosell, J. and Rodríguez-Revenga, L. and Karlberg, O. and Sauer, S. and Syvänen, A.C. and Mila, M.
European Journal of Human Genetics 24 (8): 1117-1123. August 2016

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin, M. and Pohl, T. and Lill, A. and Schulz, H. and Blaschke, F. and Heuser, A. and Thierfelder, L. and Donath, S. and Drenckhahn, J.D.
Journal of Molecular and Cellular Cardiology 97 : 1-14. August 2016

Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Mahmoodzadeh, S. and Haase, H. and Sporbert, A. and Rharass, T. and Panáková, D. and Morano, I.
Journal of Molecular and Cellular Cardiology 97 : 226-234. August 2016

New technologies for DNA analysis - a review of the READNA project.
McGinn, S. and Bauer, D. and Brefort, T. and Dong, L. and El-Sagheer, A. and Elsharawy, A. and Evans, G. and Falk-Sörqvist, E. and Forster, M. and Fredriksson, S. and Freeman, P. and Freitag, C. and Fritzsche, J. and Gibson, S. and Gullberg, M. and Gut, M. and Heath, S. and Heath-Brun, I. and Heron, A.J. and Hohlbein, J. and Ke, R. and Lancaster, O. and Le Reste, L. and Maglia, G. and Marie, R. and Mauger, F. and Mertes, F. and Mignardi, M. and Moens, L. and Oostmeijer, J. and Out, R. and Pedersen, J.N. and Persson, F. and Picaud, V. and Rotem, D. and Schracke, N. and Sengenes, J. and Stähler, P.F. and Stade, B. and Stoddart, D. and Teng, X. and Veal, C.D. and Zahra, N. and Bayley, H. and Beier, M. and Brown, T. and Dekker, C. and Ekström, B. and Flyvbjerg, H. and Franke, A. and Guenther, S. and Kapanidis, A.N. and Kaye, J. and Kristensen, A. and Lehrach, H. and Mangion, J. and Sauer, S. and Schyns, E. and Tost, J. and van Helvoort, J.M.L.M. and van der Zaag, P.J. and Tegenfeldt, J.O. and Brookes, A.J. and Mir, K. and Nilsson, M. and Willcocks, J.P. and Gut, I.G.
New Biotechnology 33 (3): 311-330. 25 May 2016

Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E. and Sin, C. and Zauber, H. and Wells, J.N. and Donnelly, N. and Wang, X. and Hou, J. and Chen, W. and Storchova, Z. and Marsh, J.A. and Valleriani, A. and Selbach, M.
Cell 167 (3): 803-815. 20 October 2016

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
Meiser, J. and Delcambre, S. and Wegner, A. and Jaeger, C. and Ghelfi, J. and D'Herouel, A.F. and Dong, X. and Weindl, D. and Stautner, C. and Nonnenmacher, Y. and Michelucci, A. and Popp, O. and Giesert, F. and Schildknecht, S. and Kraemer, L. and Schneider, J.G. and Woitalla, D. and Wurst, W. and Skupin, A. and Weisenhorn, D.M.V. and Krueger, R. and Leist, M. and Hiller, K.
Neurobiology of Disease 89 : 112-125. May 2016

Proteogenomics connects somatic mutations to signalling in breast cancer.
Mertins, P. and Mani, D.R. and Ruggles, K.V. and Gillette, M.A. and Clauser, K.R. and Wang, P. and Wang, X. and Qiao, J.W. and Cao, S. and Petralia, F. and Kawaler, E. and Mundt, F. and Krug, K. and Tu, Z. and Lei, J.T. and Gatza, M.L. and Wilkerson, M. and Perou, C.M. and Yellapantula, V. and Huang, K.L. and Lin, C. and McLellan, M.D. and Yan, P. and Davies, S.R. and Townsend, R.R. and Skates, S.J. and Wang, J. and Zhang, B. and Kinsinger, C.R. and Mesri, M. and Rodriguez, H. and Ding, L. and Paulovich, A.G. and Fenyoe, D. and Ellis, M.J. and Carr, S.A.
Nature 534 (7605): 55-62. 2 June 2016

HLA-MA: Simple yet powerful matching of samples using HLA typing results.
Messerschmidt, C. and Holtgrewe, M. and Beule, D.
bioRxiv : 066548. 24 August 2016

ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells.
Mueller, R. and Weirick, T. and John, D. and Militello, G. and Chen, W. and Dimmeler, S. and Uchida, S.
Scientific Reports 6 : 32475. 1 September 2016

Cardiomyocyte-derived CXCL12 is not involved in cardiogenesis but plays a crucial role in myocardial infarction.
Mühlstedt, S. and Ghadge, S.K. and Duchene, J. and Qadri, F. and Järve, A. and Vilianovich, L. and Popova, E. and Pohlmann, A. and Niendorf, T. and Boyé, P. and Özcelik, C. and Bader, M.
Journal of Molecular Medicine 94 (9): 1005-1014. September 2016

Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains.
Nachshon, A. and Abu-Toamih Atamni, H.J. and Steuerman, Y. and Sheikh-Hamed, R. and Dorman, A. and Mott, R. and Dohm, J.C. and Lehrach, H. and Sultan, M. and Shamir, R. and Sauer, S. and Himmelbauer, H. and Iraqi, F.A. and Gat-Viks, I.
Frontiers in Genetics 7 : 172. 5 October 2016

IFNs modify the proteome of Legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid.
Naujoks, J. and Tabeling, C. and Dill, B.D. and Hoffmann, C. and Brown, A.S. and Kunze, M. and Kempa, S. and Peter, A. and Mollenkopf, H.J. and Dorhoi, A. and Kershaw, O. and Gruber, A.D. and Sander, L.E. and Witzenrath, M. and Herold, S. and Nerlich, A. and Hocke, A.C. and van Driel, I. and Suttorp, N. and Bedoui, S. and Hilbi, H. and Trost, M. and Opitz, B.
PLoS Pathogens 12 (2): e1005408. 1 February 2016

From ultrahigh to extreme field magnetic resonance: where physics, biology and medicine meet.
Niendorf, T. and Barth, M. and Kober, F. and Trattnig, S.
Magnetic Resonance Materials in Physics Biology and Medicine 29 (3): 309-311. June 2016

What do BOLD MR imaging changes in donors' remaining kidneys tell us?
Niendorf, T. and Flemming, B. and Evans, R.G. and Seeliger, E.
Radiology 281 (2): 653-655. November 2016

Organ siderosis and hemophagocytosis during acute graft-versus-host disease.
Nogai, A. and Shi, Y. and Perez-Hernandez, D. and Cordes, S. and Mengwasser, J. and Mertlitz, S. and Riesner, K. and Kalupa, M. and Erdmann, J.H. and Ziebig, R. and Dittmar, G. and Penack, O.
Haematologica 101 (8): e344-e346. August 2016

Imprinting of skin/inflammation homing in CD4+ T cells is controlled by DNA methylation within the fucosyltransferase 7 gene.
Pink, M. and Ratsch, B.A. and Mardahl, M. and Durek, P. and Polansky, J.K. and Karl, M. and Baumgrass, R. and Wallner, S. and Cadenas, C. and Gianmoena, K. and Floess, S. and Chen, W. and Nordstroem, K. and Tierling, S. and Olek, S. and Walter, J. and Hamann, A. and Syrbe, U.
Journal of Immunology 197 (8): 3406-3414. 15 October 2016

Data of oxygen- and pH-dependent oxidation of resveratrol.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
Data in Brief 9 : 433-437. December 2016

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
Free Radical Biology and Medicine 99 : 608-622. October 2016

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
bioRxiv : 045567. 24 March 2016

CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia.
Przybyl, L. and Haase, N. and Golic, M. and Rugor, J. and Solano, M.E. and Arck, P.C. and Gauster, M. and Huppertz, B. and Emontzpohl, C. and Stoppe, C. and Bernhagen, J. and Leng, L. and Bucala, R. and Schulz, H. and Heuser, A. and Weedon-Fekjær, S. and Johnsen, G.M. and Peetz, D. and Luft, F.C. and Staff, A.C. and Müller, D.N. and Dechend, R. and Herse, F.
Circulation Research 119 (1): 55-68. 24 June 2016

Normothermic mouse functional MRI of acute focal thermostimulation for probing nociception.
Reimann, H.M. and Hentschel, J. and Marek, J. and Huelnhagen, T. and Todiras, M. and Kox, S. and Waiczies, S. and Hodge, R. and Bader, M. and Pohlmann, A. and Niendorf, T.
Scientific Reports 6 : 17230. 29 January 2016

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
Roest, H.L. and Sachsenberg, T. and Aiche, S. and Bielow, C. and Weisser, H. and Aicheler, F. and Andreotti, S. and Ehrlich, H.C. and Gutenbrunner, P. and Kenar, E. and Liang, X. and Nahnsen, S. and Nilse, L. and Pfeuffer, J. and Rosenberger, G. and Rurik, M. and Schmitt, U. and Veit, J. and Walzer, M. and Wojnar, D. and Wolski, W.E. and Schilling, O. and Choudhary, J.S. and Malmstroem, L. and Aebersold, R. and Reinert, K. and Kohlbacher, O.
Nature Methods 13 (9): 741-748. September 2016

An analysis of the sensitivity of proteogenomic mapping of somatic mutations and novel splicing events in cancer.
Ruggles, K.V. and Tang, Z. and Wang, X. and Grover, H. and Askenazi, M. and Teubl, J. and Cao, S. and McLellan, M.D. and Clauser, K.R. and Tabb, D.L. and Mertins, P. and Slebos, R. and Erdmann-Gilmore, P. and Li, S. and Gunawardena, H.P. and Xie, L. and Liu, T. and Zhou, J.Y. and Sun, S. and Hoadley, K.A. and Perou, C.M. and Chen, X. and Davies, S.R. and Maher, C.A. and Kinsinger, C.R. and Rodland, K.D. and Zhang, H. and Zhang, Z. and Ding, L. and Townsend, R.R. and Rodriguez, H. and Chan, D. and Smith, R.D. and Liebler, D.C. and Carr, S.A. and Payne, S. and Ellis, M.J. and Fenyö, D.
Molecular & Cellular Proteomics 15 (3): 1060-1071. 1 March 2016

Metabolic profiling as well as stable isotope assisted metabolic and proteomic analysis of RAW 264.7 macrophages exposed to ship engine aerosol emissions: different effects of heavy fuel Oil and refined diesel fuel.
Sapcariu, S.C. and Kanashova, T. and Dilger, M. and Diabate, S. and Oeder, S. and Passig, J. and Radischat, C. and Buters, J. and Sippula, O. and Streibel, T. and Paur, H.R. and Schlager, C. and Muelhopt, S. and Stengel, B. and Rabe, R. and Harndorf, H. and Krebs, T. and Karg, E. and Groeger, T. and Weiss, C. and Dittmar, G. and Hiller, K. and Zimmermann, R.
PLoS ONE 11 (6): e0157964. 27 June 2016

Rewinding the process of mammalian extinction.
Saragusty, J. and Diecke, S. and Drukker, M. and Durrant, B. and Friedrich Ben-Nun, I. and Galli, C. and Goeritz, F. and Hayashi, K. and Hermes, R. and Holtze, S. and Johnson, S. and Lazzari, G. and Loi, P. and Loring, J.F. and Okita, K. and Renfree, M.B. and Seet, S. and Voracek, T. and Stejskal, J. and Ryder, O.A. and Hildebrandt, T.B.
Zoo Biology 35 (4): 280-292. July 2016

OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
Simandi, Z. and Horvath, A. and Wright, L.C. and Cuaranta-Monroy, I. and De Luca, I. and Karolyi, K. and Sauer, S. and Deleuze, J.F. and Gudas, L.J. and Cowley, S.M. and Nagy, L.
Molecular Cell 63 (4): 647-661. 18 August 2016

MRI phase changes in multiple sclerosis vs neuromyelitis optica lesions at 7T.
Sinnecker, T. and Schumacher, S. and Mueller, K. and Pache, F. and Dusek, P. and Harms, L. and Ruprecht, K. and Nytrova, P. and Chawla, S. and Niendorf, T. and Kister, I. and Paul, F. and Ge, Y. and Wuerfel, J.
Neurology Neuroimmunology & Neuroinflammation 3 (4): e259. August 2016

Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes.
Spur, E.M. and Althof, N. and Respondek, D. and Klingel, K. and Heuser, A. and Overkleeft, H.S. and Voigt, A.
Toxicology 353-354 : 34-47. 15 April 2016

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos, K. and Gatsiou, A. and Stamatelopoulos, K. and Perisic Matic, L. and John, D. and Lunella, F.F. and Jae, N. and Rossbach, O. and Amrhein, C. and Sigala, F. and Boon, R.A. and Fuertig, B. and Manavski, Y. and You, X. and Uchida, S. and Keller, T. and Boeckel, J.N. and Franco-Cereceda, A. and Maegdefessel, L. and Chen, W. and Schwalbe, H. and Bindereif, A. and Eriksson, P. and Hedin, U. and Zeiher, A.M. and Dimmeler, S.
Nature Medicine 22 (10): 1140-1150. October 2016

A comprehensive RNA sequencing analysis of the adeno-associated virus (AAV) type 2 transcriptome reveals novel AAV transcripts, splice variants, and derived proteins.
Stutika, C. and Gogol-Doering, A. and Botschen, L. and Mietzsch, M. and Weger, S. and Feldkamp, M. and Chen, W. and Heilbronn, R.
Journal of Virology 90 (3): 1278-1289. February 2016

Comprehensive small RNA-Seq of adeno-associated virus (AAV)-infected human cells detects patterns of novel, non-coding AAV RNAs in the absence of cellular miRNA regulation.
Stutika, C. and Mietzsch, M. and Gogol-Doering, A. and Weger, S. and Sohn, M. and Chen, W. and Heilbronn, R.
PLoS ONE 11 (9): e0161454. 9 September 2016

Omega-3 and alpha-tocopherol provide more protection against contaminants in novel feeds for Atlantic salmon (Salmo salar L.) than omega-6 and gamma tocopherol.
Søfteland, L. and Berntssen, M.H.G. and Kirwan, J.A. and Størseth, T.R. and Viant, M.R. and Torstensen, B.E. and Waagbø, R. and Olsvik, P.A.
Toxicology Reports 3 : 211-224. 14 January 2016

Reproducibility of differential proteomic technologies in CPTAC fractionated xenografts.
Tabb, D.L. and Wang, X. and Carr, S.A. and Clauser, K.R. and Mertins, P. and Chambers, M.C. and Holman, J.D. and Wang, J. and Zhang, B. and Zimmerman, L.J. and Chen, X. and Gunawardena, H.P. and Davies, S.R. and Ellis, M.J.C. and Li, S. and Townsend, R.R. and Boja, E.S. and Ketchum, K.A. and Kinsinger, C.R. and Mesri, M. and Rodriguez, H. and Liu, T. and Kim, S. and McDermott, J.E. and Payne, S.H. and Petyuk, V.A. and Rodland, K.D. and Smith, R.D. and Yang, F. and Chan, D.W. and Zhang, B. and Zhang, H. and Zhang, Z. and Zhou, J.Y. and Liebler, D.C.
Journal of Proteome Research 15 (3): 691-706. 4 March 2016

TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic.
Tamowski, S. and Luo, J. and Kanzler, B. and Whitelaw, B. and Crispo, M. and Doglio, L. and Jerchow, B. and Parker-Thornburg, J.
Transgenic Research 25 (4): 553-559. August 2016

Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.
Taschenberger, H. and Woehler, A. and Neher, E.
Proceedings of the National Academy of Sciences of the United States of America 113 (31): E4548-E4557. 2 August 2016

Predicting chronic copper and nickel reproductive toxicity to Daphnia pulex-pulicaria from whole-animal metabolic profiles.
Taylor, N.S. and Kirwan, J.A. and Johnson, C. and Yan, N.D. and Viant, M.R. and Gunn, J.M. and McGeer, J.C.
Environmental Pollution 212 : 325-329. May 2016

Metabolomics confirms that dissolved organic carbon mitigates copper toxicity.
Taylor, N.S. and Kirwan, J.A. and Yan, N.D. and Viant, M.R. and Gunn, J.M. and McGeer, J.C.
Environmental Toxicology and Chemistry 35 (3): 635-644. March 2016

Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements.
Telorac, J. and Prykhozhij, S.V. and Schöne, S. and Meierhofer, D. and Sauer, S. and Thomas-Chollier, M. and Meijsing, S.H.
Nucleic Acids Research 44 (13): 6142-6156. 27 July 2016

RNF4-dependent oncogene activation by protein stabilization.
Thomas, J.J. and Abed, M. and Heuberger, J. and Novak, R. and Zohar, Y. and Beltra-Lopez, A.P. and Trausch-Azar, J.S. and Ilagan, M.X.G. and Benhamou, D. and Dittmar, G. and Kopan, R. and Birchmeier, W. and Schwartz, A.L. and Orian, A.
Cell Reports 16 (12): 3388-3400. 20 September 2016

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Van Haute, L. and Dietmann, S. and Kremer, L. and Hussain, S. and Pearce, S.F. and Powell, C.A. and Rorbach, J. and Lantaff, R. and Blanco, S. and Sauer, S. and Kotzaeridou, U. and Hoffmann, G.F. and Memari, Y. and Kolb-Kokocinski, A. and Durbin, R. and Mayr, J.A. and Frye, M. and Prokisch, H. and Minczuk, M.
Nature Communications 7 : 12039. 30 June 2016

Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice.
Viola, J.R. and Lemnitzer, P. and Jansen, Y. and Csaba, G. and Winter, C. and Neideck, C. and Silvestre-Roig, C. and Dittmar, G. and Doering, Y. and Drechsler, M. and Weber, C. and Zimmer, R. and Cenac, N. and Soehnlein, O.
Circulation Research 119 (9): 1030-1038. 14 October 2016

The traveling heads: multicenter brain imaging at 7 Tesla.
Voelker, M.N. and Kraff, O. and Brenner, D. and Wollrab, A. and Weinberger, O. and Berger, M.C. and Robinson, S. and Bogner, W. and Wiggins, C. and Trampel, R. and Stoecker, T. and Niendorf, T. and Quick, H.H. and Norris, D.G. and Ladd, M.E. and Speck, O.
Magnetic Resonance Materials in Physics Biology and Medicine 29 (3): 399-415. June 2016

Analysis of genes involved in body weight regulation by targeted re-sequencing.
Volckmar, A.L. and Han, C.T. and Pütter, C. and Haas, S. and Vogel, C.I.G. and Knoll, N. and Struve, C. and Göbel, M. and Haas, K. and Herrfurth, N. and Jarick, I. and Grallert, H. and Schürmann, A. and Al-Hasani, H. and Hebebrand, J. and Sauer, S. and Hinney, A.
PLoS ONE 11 (2): e0147904. 1 February 2016

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation.
Vučićević, D. and Gehre, M. and Dhamija, S. and Friis-Hansen, L. and Meierhofer, D. and Sauer, S. and Ørom, U.A.
Oncotarget 7 (23): 33934-33947. 7 June 2016

TTC25 deficiency results in defects of the outer dynein arm docking machinery and primary ciliary dyskinesia with left-right body asymmetry randomization.
Wallmeier, J. and Shiratori, H. and Dougherty, G.W. and Edelbusch, C. and Hjeij, R. and Loges, N.T. and Menchen, T. and Olbrich, H. and Pennekamp, P. and Raidt, J. and Werner, C. and Minegishi, K. and Shinohara, K. and Asai, Y. and Takaoka, K. and Lee, C. and Griese, M. and Memari, Y. and Durbin, R. and Kolb-Kokocinski, A. and Sauer, S. and Wallingford, J.B. and Hamada, H. and Omran, H.
American Journal of Human Genetics 99 (2): 460-469. 4 August 2016

Epigenetic dynamics of monocyte-to-macrophage differentiation.
Wallner, S. and Schroeder, C. and Leitão, E. and Berulava, T. and Haak, C. and Beißer, D. and Rahmann, S. and Richter, A.S. and Manke, T. and Bönisch, U. and Arrigoni, L. and Fröhler, S. and Klironomos, F. and Chen, W. and Rajewsky, N. and Müller, F. and Ebert, P. and Lengauer, T. and Barann, M. and Rosenstiel, P. and Gasparoni, G. and Nordström, K. and Walter, J. and Brors, B. and Zipprich, G. and Felder, B. and Klein-Hitpass, L. and Attenberger, C. and Schmitz, G. and Horsthemke, B.
Epigenetics & Chromatin 9 : 33. 29 July 2016

Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets.
Wang, A.L. and Gold, J.M. and Tompkins, N. and Heymann, M. and Harrington, K.I. and Fraden, S.
European Physical Journal Special Topics 225 (1): 211-227. February 2016

Pervasive isoform-specific translational regulation via alternative transcription start sites in mammals.
Wang, X. and Hou, J. and Quedenau, C. and Chen, W.
Molecular Systems Biology 12 (7): 875. 18 July 2016

Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
Weber, A. and Cohen, I. and Popp, O. and Dittmar, G. and Reiss, Y. and Sommer, T. and Ravid, T. and Jarosch, E.
Molecular Cell 63 (5): 827-839. 1 September 2016

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
Weber, T. and Namikawa, K. and Winter, B. and Müller-Brown, K. and Kühn, R. and Wurst, W. and Köster, R.W.
Development 143 (22): 4279-4287. 15 November 2016

Genome editing in mice using TALE nucleases.
Wefers, B. and Brandl, C. and Ortiz, O. and Wurst, W. and Kühn, R.
Methods in Molecular Biology 1338 : 229-243. 2016

Amorfrutin C induces apoptosis and inhibits proliferation in colon cancer cells through targeting mitochondria.
Weidner, C. and Rousseau, M. and Micikas, R.J. and Fischer, C. and Plauth, A. and Wowro, S.J. and Siems, K. and Hetterling, G. and Kliem, M. and Schroeder, F.C. and Sauer, S.
Journal of Natural Products 79 (1): 2-12. 22 January 2016

Iberis amara extract induces intracellular formation of reactive oxygen species and inhibits colon cancer.
Weidner, C. and Rousseau, M. and Plauth, A. and Wowro, S.J. and Fischer, C. and Abdel-Aziz, H. and Sauer, S.
PLoS ONE 11 (4): e0152398. 6 April 2016

Local multi-channel RF surface coil versus body RF coil transmission for cardiac magnetic resonance at 3 Tesla: which configuration is winning the game?
Weinberger, O. and Winter, L. and Dieringer, M.A. and Els, A. and Oezerdem, C. and Rieger, J. and Kuehne, A. and Cassara, A.M. and Pfeiffer, H. and Wetterling, F. and Niendorf, T.
PLoS ONE 11 (9): e0161863. 6 September 2016

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond.
Winter, L. and Niendorf, T.
Magnetic Resonance Materials in Physics Biology and Medicine 29 (3): 641-656. June 2016

Quantitative analysis of cancer metabolism: From pSIRM to MFA.
Zasada, C. and Kempa, S.
Recent Results in Cancer Research 207 (207): 207-220. 25 August 2016

PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells.
Zessin, P.J.M. and Sporbert, A. and Heilemann, M.
Scientific Reports 6 : 18779. 13 January 2016

52 genetic loci influencing myocardial mass.
van der Harst, P. and van Setten, J. and Verweij, N. and Vogler, G. and Franke, L. and Maurano, M.T. and Wang, X. and Mateo Leach, I. and Eijgelsheim, M. and Sotoodehnia, N. and Hayward, C. and Sorice, R. and Meirelles, O. and Lyytikaeinen, L.P. and Polašek, O. and Tanaka, T. and Arking, D.E. and Ulivi, S. and Trompet, S. and Mueller-Nurasyid, M. and Smith, A.V. and Dörr, M. and Kerr, K.F. and Magnani, J.W. and Del Greco, M.F. and Zhang, W. and Nolte, I.M. and Silva, C.T. and Padmanabhan, S. and Tragante, V. and Esko, T. and Abecasis, G.R. and Adriaens, M.E. and Andersen, K. and Barnett, P. and Bis, J.C. and Bodmer, R. and Buckley, B.M. and Campbell, H. and Cannon, M.V. and Chakravarti, A. and Chen, L.Y. and Delitala, A. and Devereux, R.B. and Doevendans, P.A. and Dominiczak, A.F. and Ferrucci, L. and Ford, I. and Gieger, C. and Harris, T.B. and Haugen, E. and Heinig, M. and Hernandez, D.G. and Hillege, H.L. and Hirschhorn, J.N. and Hofman, A. and Hubner, N. and Hwang, S.J. and Iorio, A. and Kaehoenen, M. and Kellis, M. and Kolcic, I. and Kooner, Is.K. and Kooner, J.S. and Kors, J.A. and Lakatta, E.G. and Lage, K. and Launer, L.J. and Levy, D. and Lundby, A. and Macfarlane, P.W. and May, D. and Meitinger, T. and Metspalu, A. and Nappo, S. and Naitza, S. and Neph, S. and Nord, A.S. and Nutile, T. and Okin, P.M. and Olsen, J.V. and Oostra, B.A. and Penninger, J.M. and Pennacchio, L.A. and Pers, T.H. and Perz, S. and Peters, A. and Pinto, Y.M. and Pfeufer, A. and Pilia, M.G. and Pramstaller, P.P. and Prins, B.P. and Raitakari, O.T. and Raychaudhuri, S. and Rice, K.M. and Rossin, E.J. and Rotter, J.I. and Schaefer, S. and Schlessinger, D. and Schmidt, C.O. and Sehmi, J. and Sillje, H.H.W. and Sinagra, G. and Sinner, M.F. and Slowikowski, K. and Soliman, E.Z. and Spector, T.D. and Spiering, W. and Stamatoyannopoulos, J.A. and Stolk, R.P. and Strauch, K. and Tan, S.T. and Tarasov, K.V. and Trinh, B. and Uitterlinden, A.G. and van den Boogaard, M. and van Duijn, C.M. and van Gilst, W.H. and Viikari, J.S. and Visscher, P.M. and Vitart, V. and Völker, U. and Waldenberger, M. and Weichenberger, C.X. and Westra, H.J. and Wijmenga, C. and Wolffenbuttel, B.H. and Yang, J. and Bezzina, C.R. and Munroe, P.B. and Snieder, H. and Wright, A.F. and Rudan, I. and Boyer, L.A. and Asselbergs, F.W. and van Veldhuisen, D.J. and Stricker, B.H. and Psaty, B.M. and Ciullo, M. and Sanna, S. and Lehtimäki, T. and Wilson, J.F. and Bandinelli, S. and Alonso, A. and Gasparini, P. and Jukema, J.W. and Kääb, S. and Gudnason, V. and Felix, S.B. and Heckbert, S.R. and de Boer, R.A. and Newton-Cheh, C. and Hicks, A.A. and Chambers, J.C. and Jamshidi, Y. and Visel, A. and Christoffels, V.M. and Isaacs, A. and Samani, N.J. and de Bakker, P.I.W.
Journal of the American College of Cardiology 68 (13): 1435-1448. 27 September 2016

2015

A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors.
Aidhen, I.S. and Mukkamala, R. and Weidner, C. and Sauer, S.
Organic Letters 17 (2): 194-197. 16 January 2015

genomation: a toolkit to summarize, annotate and visualize genomic intervals.
Akalin, A. and Franke, V. and Vlahoviček, K. and Mason, C.E. and Schübeler, D.
Bioinformatics 31 (7): 1127-1129. 1 April 2015

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation.
Baubec, T. and Colombo, D.F. and Wirbelauer, C. and Schmidt, J. and Burger, L. and Krebs, A.R. and Akalin, A. and Schübeler, D.
Nature 520 (7546): 243-247. 9 April 2015

A t(3;9)(q25.1;q34.3) translocation leading to OLFM1 fusion transcripts in Gilles de la Tourette syndrome, OCD and ADHD.
Bertelsen, B. and Melchior, L. and Jensen, L.R. and Groth, C. and Nazaryan, L. and Debes, N.M. and Skov, L. and Xie, G. and Sun, W. and Brondum-Nielsen, K. and Kuss, A.W. and Chen, W. and Tuemer, Z.
Psychiatry Research 225 (3): 268-275. 28 February 2015

DoRiNA 2.0-upgrading the doRiNA database of RNA interactions in post-transcriptional regulation.
Blin, K. and Dieterich, C. and Wurmus, R. and Rajewsky, N. and Landthaler, M. and Akalin, A.
Nucleic Acids Research 43 (Database issue): D160-D167. 28 January 2015

Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N. and Jae, N. and Heumueller, A.W. and Chen, W. and Boon, R.A. and Stellos, K. and Zeiher, A.M. and John, D. and Uchida, S. and Dimmeler, S.
Circulation Research 117 (10): 884-890. 23 October 2015

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.
Brandl, C. and Ortiz, O. and Röttig, B. and Wefers, B. and Wurst, W. and Kühn, R.
FEBS Open Bio 5 : 26-35. 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. and Weber, T. and Wefers, B. and Wurst, W. and Sander, S. and Rajewsky, K. and Kühn, R.
Nature Biotechnology 33 (5): 543-548. May 2015

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.
Correia, J.C. and Massart, J. and de Boer, J.F. and Porsmyr-Palmertz, M. and Martínez-Redondo, V. and Agudelo, L.Z. and Sinha, I. and Meierhofer, D. and Ribeiro, V. and Björnholm, M. and Sauer, S. and Dahlman-Wright, K. and Zierath, J.R. and Groen, A.K. and Ruas, J.L.
Molecular Metabolism 4 (12): 891-902. December 2015

Reproducible and user-controlled software environments in HPC with Guix.
Courtes, L. and Wurmus, R.
Lecture Notes in Computer Science 9523 : 579-591. 2015

Gene regulatory network evolution through augmenting topologies.
Cussat-Blanc, S. and Harrington, K. and Pollack, J.
IEEE Transactions on Evolutionary Computation 19 (6): 823-837. December 2015

Genetically-regulated neuromodulation facilitates multi-task reinforcement learning.
Cussat-Blanc, S. and Harrington, K.I.S.
In: GECCO '15: Genetic and Evolutionary Computation Conference, Jul 2015, Madrid, Spain. July 2015

SILAC for biomarker discovery.
Dittmar, G. and Selbach, M.
Proteomics Clinical Applications 9 (3-4): 301-306. April 2015

Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3.
Doddaballapur, A. and Michalik, K.M. and Manavski, Y. and Lucas, T. and Houtkooper, R.H. and You, X. and Chen, W. and Zeiher, A.M. and Potente, M. and Dimmeler, S. and Boon, R.A.
Arteriosclerosis Thrombosis and Vascular Biology 35 (1): 137-145. January 2015

Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart.
Drenckhahn, J.D. and Strasen, J. and Heinecke, K. and Langner, P. and Yin, K.V. and Skole, F. and Hennig, M. and Spallek, B. and Fischer, R. and Blaschke, F. and Heuser, A. and Cox, T.C. and Black, M.J. and Thierfelder, L.
Cardiovascular Research 106 (1): 43-54. 1 April 2015

Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
Ebert, A.D. and Diecke, S. and Chen, I.Y. and Wu, J.C.
EMBO Molecular Medicine 7 (9): 1090-1103. 16 July 2015

GORAB missense mutations disrupt RAB6 and ARF5 binding and golgi targeting.
Egerer, J. and Emmerich, D. and Fischer-Zirnsak, B. and Chan, W.L. and Meierhofer, D. and Tuysuz, B. and Marschner, K. and Sauer, S. and Barr, F.A. and Mundlos, S. and Kornak, U.
Journal of Investigative Dermatology 135 (10): 2368-2376. October 2015

A regression-based analysis of ribosome-profiling data reveals a conserved complexity to mammalian translation.
Fields, A.P. and Rodriguez, E.H. and Jovanovic, M. and Stern-Ginossar, N. and Haas, B.J. and Mertins, P. and Raychowdhury, R. and Hacohen, N. and Carr, S.A. and Ingolia, N.T. and Regev, A. and Weissman, J.S.
Molecular Cell 60 (5): 816-827. 3 December 2015

Immunofluorescence analysis and diagnosis of primary ciliary dyskinesia with radial spoke defects.
Frommer, A. and Hjeij, R. and Loges, N.T. and Edelbusch, C. and Jahnke, C. and Raidt, J. and Werner, C. and Wallmeier, J. and Große-Onnebrink, J. and Olbrich, H. and Cindrić, S. and Jaspers, M. and Boon, M. and Memari, Y. and Durbin, R. and Kolb-Kokocinski, A. and Sauer, S. and Marthin, J.K. and Nielsen, K.G. and Amirav, I. and Elias, N. and Kerem, E. and Shoseyov, D. and Haeffner, K. and Omran, H.
American Journal of Respiratory Cell and Molecular Biology 53 (4): 563-573. 1 October 2015

Amorfrutins are natural PPARγ agonists with potent anti-inflammatory properties.
Fuhr, L. and Rousseau, M. and Plauth, A. and Schroeder, F.C. and Sauer, S.
Journal of Natural Products 78 (5): 1160-1164. 22 May 2015

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao, Q. and Sun, W. and Ballegeer, M. and Libert, C. and Chen, W.
Molecular Systems Biology 11 (7): 816. 1 July 2015

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
Garrett, L. and Zhang, J. and Zimprich, A. and Niedermeier, K.M. and Fuchs, H. and Gailus-Durner, V. and Hrabe de Angelis, M. and Vogt Weisenhorn, D. and Wurst, W. and Hoelter, S.M.
Frontiers in Behavioral Neuroscience 9 : 302. 12 November 2015

Sodium MRI of the human heart at 7.0 T: preliminary results.
Graessl, A. and Ruehle, A. and Waiczies, H. and Resetar, A. and Hoffmann, S.H. and Rieger, J. and Wetterling, F. and Winter, L. and Nagel, A.M. and Niendorf, T.
NMR in Biomedicine 28 (8): 967-975. August 2015

Monitoring hemodynamics and oxygenation of the kidney in rats by a combined near-infrared spectroscopy and invasive probe approach.
Grosenick, D. and Cantow, K. and Arakelyan, K. and Wabnitz, H. and Flemming, B. and Skalweit, A. and Ladwig, M. and Macdonald, R. and Niendorf, T. and Seeliger, E.
In: UNSPECIFIED. 16 July 2015

Characterization of hemodynamics and oxygenation in the renal cortex of rats.
Grosenick, D. and Wabnitz, H. and Macdonald, R. and Niendorf, T. and Cantow, K. and Flemming, B. and Arakelyan, K. and Seeliger, E.
In: UNSPECIFIED. 5 March 2015

A protocol for chemical mutagenesis in Strongyloides ratti.
Guo, L. and Chang, Z. and Dieterich, C. and Streit, A.
Experimental Parasitology 158 : 2-7. November 2015

Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement.
Haack, T.B. and Jackson, C.B. and Murayama, K. and Kremer, L.S. and Schaller, A. and Kotzaeridou, U. and de Vries, M.C. and Schottmann, G. and Santra, S. and Büchner, B. and Wieland, T. and Graf, E. and Freisinger, P. and Eggimann, S. and Ohtake, A. and Okazaki, Y. and Kohda, M. and Kishita, Y. and Tokuzawa, Y. and Sauer, S. and Memari, Y. and Kolb-Kokocinski, A. and Durbin, R. and Hasselmann, O. and Cremer, K. and Albrecht, B. and Wieczorek, D. and Engels, H. and Hahn, D. and Zink, A.M. and Alston, C.L. and Taylor, R.W. and Rodenburg, R.J. and Trollmann, R. and Sperl, W. and Strom, T.M. and Hoffmann, G.F. and Mayr, J.A. and Meitinger, T. and Bolognini, R. and Schuelke, M. and Nuoffer, J.M. and Kölker, S. and Prokisch, H. and Klopstock, T.
Annals of Clinical and Translational Neurology 2 (5): 492-509. May 2015

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
Haftmann, C. and Stittrich, A.B. and Zimmermann, J. and Fang, Z. and Hradilkova, K. and Bardua, M. and Westendorf, K. and Heinz, G.A. and Riedel, R. and Siede, J. and Lehmann, K. and Weinberger, E.E. and Zimmel, D. and Lauer, U. and Häupl, T. and Sieper, J. and Backhaus, M. and Neumann, C. and Hoffmann, U. and Porstner, M. and Chen, W. and Grün, J.R. and Baumgrass, R. and Matz, M. and Löhning, M. and Scheffold, A. and Wittmann, J. and Chang, H.D. and Rajewsky, N. and Jäck, H.M. and Radbruch, A. and Mashreghi, M.F.
European Journal of Immunology 45 (4): 1192-1205. April 2015

GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C. and Moroni, M. and Lima, W.C. and Wende, H. and Kirchner, M. and Adelfinger, L. and Schrenk-Siemens, K. and Tappe-Theodor, A. and Wetzel, C. and Kuich, P.H. and Gassmann, M. and Roggenkamp, D. and Bettler, B. and Lewin, G.R. and Selbach, M. and Siemens, J.
Cell 160 (4): 759-770. 12 February 2015

Crosstalk between two bZIP signaling pathways orchestrates salt-induced metabolic reprogramming in arabidopsis roots.
Hartmann, L. and Pedrotti, L. and Weiste, C. and Fekete, A. and Schierstaedt, J. and Göttler, J. and Kempa, S. and Krischke, M. and Dietrich, K. and Mueller, M.J. and Vicente-Carbajosa, J. and Hanson, J. and Dröge-Laser, W.
Plant Cell 27 (8): 2244-2260. August 2015

Extensive allele-specific translational regulation in hybrid mice.
Hou, J. and Wang, X. and McShane, E. and Zauber, H. and Sun, W. and Selbach, M. and Chen, W.
Molecular Systems Biology 11 (8): 825. 7 August 2015

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.
Hu, F. and a Dzaye, O.D. and Hahn, A. and Yu, Y. and Scavetta, R.J. and Dittmar, G. and Kaczmarek, A.K. and Dunning, K.R. and Ricciardelli, C. and Rinnenthal, J.L. and Heppner, F.L. and Lehnardt, S. and Synowitz, M. and Wolf, S.A. and Kettenmann, H.
Neuro-Oncology 17 (2): 200-210. February 2015

Neutrophil serine proteases exert proteolytic activity on endothelial cells.
Jerke, U. and Perez Hernandez, D. and Beaudette, P. and Korkmaz, B. and Dittmar, G. and Kettritz, R.
Kidney International 88 (4): 764-775. October 2015

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
Jia, S. and Ivanov, A. and Blasevic, D. and Müller, T. and Purfürst, B. and Sun, W. and Chen, W. and Poy, M.N. and Rajewsky, N. and Birchmeier, C.
EMBO Journal 34 (10): 1417-1433. 12 May 2015

Dynamic profiling of the protein life cycle in response to pathogens.
Jovanovic, M. and Rooney, M.S. and Mertins, P. and Przybylski, D. and Chevrier, N. and Satija, R. and Rodriguez, E.H. and Fields, A.P. and Schwartz, S. and Raychowdhury, R. and Mumbach, M.R. and Eisenhaure, T. and Rabani, M. and Gennert, D. and Lu, D. and Delorey, T. and Weissman, J.S. and Carr, S.A. and Hacohen, N. and Regev, A.
Science 347 (6226): 1259038. 6 March 2015

Homozygous loss-of-function variants in european cosmopolitan and isolate populations.
Kaiser, V.B. and Svinti, V. and Prendergast, J.G. and Chau, Y.Y. and Campbell, A. and Patarcic, I. and Barroso, I. and Joshi, P.K. and Hastie, N.D. and Miljkovic, A. and Taylor, M.S. and Enroth, S. and Memari, Y. and Kolb-Kokocinski, A. and Wright, A.F. and Gyllensten, U. and Durbin, R. and Rudan, I. and Campbell, H. and Polašek, O. and Johansson, A. and Sauer, S. and Porteous, D.J. and Fraser, R.M. and Drake, C. and Vitart, V. and Hayward, C. and Semple, C.A. and Wilson, J.F.
Human Molecular Genetics 24 (19): 5464-5474. 1 October 2015

Differential proteomic analysis of mouse macrophages exposed to adsorbate-loaded heavy fuel oil derived combustion particles using an automated sample-preparation workflow.
Kanashova, T. and Popp, O. and Orasche, J. and Karg, E. and Harndorf, H. and Stengel, B. and Sklorz, M. and Streibel, T. and Zimmermann, R. and Dittmar, G.
Analytical and Bioanalytical Chemistry 407 (20): 5965-5976. August 2015

Protein kinase Ymr291w/Tda1 is essential for glucose signaling in Saccharomyces cerevisiae on the level of hexokinase isoenzyme ScHxk2 phosphorylation.
Kaps, S. and Kettner, K. and Migotti, R. and Kanashova, T. and Krause, U. and Roedel, G. and Dittmar, G. and Kriegel, T.M.
Journal of Biological Chemistry 290 (10): 6243-6255. 6 March 2015

Multiplexed, quantitative workflow for sensitive biomarker discovery in plasma yields novel candidates for early myocardial injury.
Keshishian, H. and Burgess, M.W. and Gillette, M.A. and Mertins, P. and Clauser, K.R. and Mani, D.R. and Kuhn, E.W. and Farrell, L.A. and Gerszten, R.E. and Carr, S.A.
Molecular & Cellular Proteomics 14 (9): 2375-2393. 1 September 2015

Maui-VIA: a user-friendly software for visual identification, alignment, correction, and quantification of gas chromatography-mass spectrometry data.
Kuich, P.H.J.L. and Hoffmann, N. and Kempa, S.
Frontiers in Bioengineering and Biotechnology 2 : 84. 21 January 2015

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. and Chu, V.T.
Genome Biology 16 (1): 244. 10 November 2015

Diffusionsgewichtete Magnetresonanztomografie und ihre potenziellen Anwendungsmoeglichkeiten in der Ophthalmologie [Diffusion weighted magnetic resonance imaging and its application in ophthalmology].
Lindner, T. and Langner, S. and Paul, K. and Pohlmann, A. and Hadlich, S. and Niendorf, T. and Jünemann, A. and Guthoff, R.F. and Stachs, O.
Klinische Monatsblaetter fuer Augenheilkunde 232 (12): 1386-1391. December 2015

Deep sequencing of the trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.
Llewellyn, M.S. and Messenger, L.A. and Luquetti, A.O. and Garcia, L. and Torrico, F. and Tavares, S.B.N. and Cheaib, B. and Derome, N. and Delepine, M. and Baulard, C. and Deleuze, J.F. and Sauer, S. and Miles, M.A.
PLoS Neglected Tropical Diseases 9 (4): e0003458. 7 April 2015

Ultrahigh-field MPRAGE magnetic resonance angiography at 7.0 T in patients with cerebrovascular disease.
Madai, V.I. and von Samson-Himmelstjerna, F.C. and Sandow, N. and Weiler, F. and Bauer, M. and Vajkoczy, P. and Günther, M. and Dusek, P. and von Gottberg, P. and Niendorf, T. and Wuerfel, J. and Sobesky, J.
European Journal of Radiology 84 (12): 2613-2617. December 2015

Functional proteomic analysis of repressive histone methyltransferase complexes reveals ZNF518B as a G9A regulator.
Maier, V.K. and Feeney, C.M. and Taylor, J.E. and Creech, A.L. and Qiao, J.W. and Szanto, A. and Das, P.P. and Chevrier, N. and Cifuentes-Rojas, C. and Orkin, S.H. and Carr, S.A. and Jaffe, J.D. and Mertins, P. and Lee, J.T.
Molecular & Cellular Proteomics 14 (6): 1435-1446. 1 June 2015

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.
Moussaieff, A. and Rouleau, M. and Kitsberg, D. and Cohen, M. and Levy, G. and Barasch, D. and Nemirovski, A. and Shen-Orr, S. and Laevsky, I. and Amit, M. and Bomze, D. and Elena-Herrmann, B. and Scherf, T. and Nissim-Rafinia, M. and Kempa, S. and Itskovitz-Eldor, J. and Meshorer, E. and Aberdam, D. and Nahmias, Y.
Cell Metabolism 21 (3): 392-402. 3 March 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

Improved approach for chondrogenic differentiation of human induced pluripotent stem cells.
Nejadnik, H. and Diecke, S. and Lenkov, O.D. and Chapelin, F. and Donig, J. and Tong, X. and Derugin, N. and Chan, R.C.F. and Gaur, A. and Yang, F. and Wu, J.C. and Daldrup-Link, H.E.
Stem Cell Reviews and Reports 11 (2): 242-253. April 2015

Advancing cardiovascular, neurovascular, and renal magnetic resonance imaging in small rodents using cryogenic radiofrequency coil technology.
Niendorf, T. and Pohlmann, A. and Reimann, H.M. and Waiczies, H. and Peper, E. and Huelnhagen, T. and Seeliger, E. and Schreiber, A. and Kettritz, R. and Strobel, K. and Ku, M.C. and Waiczies, S.
Frontiers in Pharmacology 6 : 255. 12 November 20