Browse by Research Area

2025

Enhancing biomarker based oncology trial matching using large language models.
Al Khoury, N., Shaik, M., Wurmus, R. and Akalin, A.
NPJ Digital Medicine 8 (1): 250. 6 May 2025

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Avery, E.G., Haag, L.M., McParland, V., Kedziora, S.M., Zigra, G.J., Valdes, D.S., Kirchner, M., Popp, O., Geisberger, S., Nonn, O., Karlsen, T.V., N'Diaye, G., Yarritu, A., Bartolomaeus, H., Bartolomaeus, T.U.P., Tagiyeva, N.A., Wimmer, M.I., Haase, N., Zhang, Y.D., Wilhelm, A., Grütz, G., Tenstad, O., Wilck, N., Forslund, S.K., Klopfleisch, R., Kühl, A.A., Atreya, R., Kempa, S., Mertins, P., Siegmund, B., Wiig, H. and Müller, D.N.
Cardiovascular Research : cvae267. 13 January 2025 (In Press)

Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion.
Barke, N, Masser, S., Stalling, D., Wyler, E., Zinzen, R.P., Schreiner, S., Bosse, J. and Landthaler, M.
bioRxiv : 2025.02.10.637450. 11 February 2025

Circulating extracellular vesicles as putative mediators of cardiovascular disease in paediatric chronic kidney disease.
Behrens, F., Holle, J., Chen, C.Y., Ginsbach, L.F., Krause, B.C., Bruning, U., Kriegel, F.L., Kaiser, T., Szijártó, I.A., Anandakumar, H., Lehmann, K., Schumacher, F., Durek, P., Heinrich, F.F., Lodka, D., Hoffmann, C., Borchardt, A.A., Peters, L., Michalick, L., Querfeld, U., Bufler, P., Luch, A., Kleuser, B., Kirwan, J.A., Forslund, S.K., Thumfahrt, J., Müller, D., Wilck, N., Mashreghi, M.F., Löber, U., Bartolomaeus, H., Kuebler, W.M. and Simmons, S.
Journal of Extracellular Vesicles 14 (3): e70062. March 2025

High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma.
Bourdier, S., Fisch, A.S., Alp, K.M., Das, R., Mertins, P. and Tinhofer, I.
Scientific Reports 15 (1): 1555. 10 January 2025

Rapid brain tumor classification from sparse epigenomic data.
Brändl, B., Steiger, M., Kubelt, C., Rohrandt, C., Zhu, Z., Evers, M., Wang, G., Schuldt, B., Afflerbach, A.K., Wong, D., Lum, A., Halldorsson, S., Djirackor, L., Leske, H., Magadeeva, S., Smičius, R., Quedenau, C., Schmidt, N.O., Schüller, U., Vik-Mo, E.O., Proescholdt, M., Riemenschneider, M.J., Zadeh, G., Ammerpohl, O., Yip, S., Synowitz, M., van Bömmel, A., Kretzmer, H. and Müller, F.J.
Nature Medicine 31 (3): 840-848. March 2025

Structural determinants of mucins in influenza virus inhibition: the role of sialylated glycans and molecular size.
Butnarasu, C., Safferthal, M., Thomas, J., Povolotsky, T.L., Diehn, R., Fentker, K., Mertins, P., Pagel, K. and Lauster, D.C.
International Journal of Biological Macromolecules 307 (Part 4): 142357. May 2025

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis.
Bögershausen, N., Cavdarli, B., Nagai, T., Milev, M.P., Wolff, A., Mehranfar, M., Schmidt, J., Choudhary, D., Gutiérrez-Gutiérrez, Ó., Cyganek, L., Saint-Dic, D., Zibat, A., Köhrer, K., Wollenweber, T.E., Wieczorek, D., Altmüller, J., Borodina, T., Kaçar, D., Haliloğlu, G., Li, Y., Thiel, C., Sacher, M., Knapik, E.W., Yigit, G. and Wollnik, B.
JCI Insight 10 (9): e173484. 8 May 2025

LINC01503-MP is a mitochondrial microprotein that promotes cell proliferation and oxidative metabolism.
Dewani, N., Ruiz-Orera, J., Popp, O., Liang, N., Sugarawa, M., Schulz, J.F., Witte, F., Sandmann, C., Tsuji, T., Blachut, S., Katagiri, T., Kondova, I., Owada, S., Yoshii, S., Kataoka, H., Kurtz, A., Nakase, H., van Heesch, S., Mertins, P., Hübner, N. and Kanda (Hübner), M.
bioRxiv : 2025.03.19.644091. 19 March 2025

Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy.
Escobar, H., Di Francescantonio, S., Smirnova, J., Graf, R., Müthel, S., Marg, A., Zhogov, A., Krishna, S., Metzler, E., Petkova, M., Daumke, O., Kühn, R. and Spuler, S.
Nature Communications 16 (1): 120. 2 January 2025

Determinants of ascending aortic morphology: cross-sectional deep learning-based analysis on 25 073 non-contrast-enhanced NAKO MRI studies.
Fay, L., Hepp, T., Winkelmann, M.T., Peters, A., Heier, M., Niendorf, T., Pischon, T., Endemann, B., Schulz-Menger, J., Krist, L., Schulze, M.B., Mikolajczyk, R., Wienke, A., Obi, N., Silenou, B.C., Lange, B., Kauczor, H.U., Lieb, W., Baurecht, H., Leitzmann, M., Trares, K., Brenner, H., Michels, K.B., Jaskulski, S., Völzke, H., Nikolaou, K., Schlett, C.L., Bamberg, F., Lescan, M., Yang, B., Küstner, T. and Gatidis, S.
European Heart Journal - Cardiovascular Imaging 26 (5): 895-907. May 2025

Sex hormone-dependent host-microbiome interactions and cardiovascular risk (XCVD): design of a longitudinal multi-omics cohort study.
Franz, K., Markó, L., Mähler, A., Chakaroun, R., Heinitz, S., Schlögl, H., Sacher, J., Steckhan, N., Dechend, R., Adams, N., Andersen, M., Glintborg, D., Viehweger, M., Bahr, L.S. and Forslund-Startceva, S.K.
BMJ Open 15 (1): e087982. 9 January 2025

Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.
Giese, W., Albrecht, J.P., Oppenheim, O., Akmeriç, E.B., Kraxner, J., Schmidt, D., Harrington, K.I. and Gerhardt, H.
Nature Communications 16 (1): 1474. 8 February 2025

Costs associated with insufficient physical activity in Germany: cross-sectional results from the baseline examination of the German national cohort (NAKO).
Gottschalk, S., König, H.H., Weber, A., Leitzmann, M.F., Stein, M.J., Peters, A., Flexeder, C., Krist, L., Willich, S.N., Nimptsch, K., Pischon, T., Gastell, S., Steindorf, K., Herbolsheimer, F., Ebert, N., Michels, K.B., Dorrn, A., Harth, V., Obi, N., Karch, A., Teismann, H., Völzke, H., Meinke-Franze, C., Klimeck, L., Seum, T.L. and Dams, J.
European Journal of Health Economics 26 (1): 117-128. February 2025

Detecting unforeseen data properties with diffusion autoencoder embeddings using spine MRI data.
Graf, R., Hunecke, F., Pohl, S., Atad, M., Moeller, H., Starck, S., Kroencke, T., Bette, S., Bamberg, F., Pischon, T., Niendorf, T., Schmidt, C., Paetzold, J.C., Rueckert, D. and Kirschke, J.S.
Lecture Notes in Computer Science 2024 (15274): 79-88. 17 January 2025

MAGO-SP: detection and correction of water-fat swaps in magnitude-only VIBE MRI.
Graf, R., Möller, H., Starck, S., Atad, M., Braun, P., Stelter, J., Peters, A., Krist, L., Willich, S.N., Völzke, H., Bülow, R., Berger, K., Pischon, T., Niendorf, T., Paetzold, J., Karampinos, D., Rueckert, D. and Kirschke, J.
arXiv : 2502.14659. 20 February 2025

Refining visceral adipose tissue quantification: influence of sex, age, and BMI on single slice estimation in 3D MRI of the German National Cohort.
Haueise, T., Schick, F., Stefan, N., Grune, E., von Itter, M.N., Kauczor, H.U., Nattenmüller, J., Norajitra, T., Nonnenmacher, T., Rospleszcz, S., Maier-Hein, K.H., Schlett, C.L., Weiss, J.B., Fischer, B., Jöckel, K.H., Krist, L., Niendorf, T., Peters, A., Sedlmeier, A.M., Willich, S.N., Bamberg, F. and Machann, J.
Zeitschrift fur Medizinische Physik 22 March 2025 (In Press)

Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration.
Heuberger, J., Liu, L., Berger, H., van den Heuvel, J., Lin, M., Müllerke, S., Bayram, S., Beccaceci, G., de Jonge, H., Gherardi, E. and Sigal, M.
Nature Communications 16 (1): 4131. 3 May 2025

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype.
Hoppe, S., Noseir, S., Yazbeck, A., Zaburannyi, N., Grossbach, J., Lyu, S.I., Velazquez Camacho, O., Müller, S., Gebauer, F., Richartz, V., Holz, B., Berg, J., Achter, V., Altmüller, J., Becker, K., Arolt, C., Meder, L., Zhao, Y., Schlößer, H., Baus, W.W., Kamp, F., Baues, C., Beyer, A., Odenthal, M., Quaas, A., Buettner, R. and Hillmer, A.M.
bioRxiv : 2025.01.28.635332. 1 February 2025

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B., Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T., Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D., Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology 168 (2): 327-343. February 2025

Reproducibility of electromagnetic field simulations of local radiofrequency transmit elements tailored for 7 T MRI.
Hubmann, M.J., Nurzed, B., Hansen, S.L., Kowal, R., Schön, N., Wenz, D., Saha, N., Lutz, M., Fiedler, T.M., Orzada, S., Winter, L., Keil, B., Maune, H., Speck, O. and Niendorf, T.
Sensors 25 (6): 1867. March 2025

Leveraging large language models for data analysis automation.
Jansen, J.A., Manukyan, A., Al Khoury, N. and Akalin, A.
PLoS ONE 20 (2): e0317084. 21 February 2025

Engineered heart muscle allografts for heart repair in primates and humans.
Jebran, A.F., Seidler, T., Tiburcy, M., Daskalaki, M., Kutschka, I., Fujita, B., Ensminger, S., Bremmer, F., Moussavi, A., Yang, H., Qin, X., Mißbach, S., Drummer, C., Baraki, H., Boretius, S., Hasenauer, C., Nette, T., Kowallick, J., Ritter, C.O., Lotz, J., Didié, M., Mietsch, M., Meyer, T., Kensah, G., Krüger, D., Sakib, M.S., Kaurani, L., Fischer, A., Dressel, R., Rodriguez-Polo, I., Stauske, M., Diecke, S., Maetz-Rensing, K., Gruber-Dujardin, E., Bleyer, M., Petersen, B., Roos, C., Zhang, L., Walter, L., Kaulfuß, S., Yigit, G., Wollnik, B., Levent, E., Roshani, B., Stahl-Henning, C., Ströbel, P., Legler, T., Riggert, J., Hellenkamp, K., Voigt, J.U., Hasenfuß, G., Hinkel, R., Wu, J.C., Behr, R. and Zimmermann, W.H.
Nature 639 (8054): 503-511. 13 March 2025

Multicenter longitudinal quality assessment of MS-based proteomics in plasma and serum.
Kardell, O., Gronauer, T., von Toerne, C., Merl-Pham, J., König, A.C., Barth, T.K., Mergner, J., Ludwig, C., Tüshaus, J., Giesbertz, P., Breimann, S., Schweizer, L., Müller, T., Kliewer, G., Distler, U., Gomez-Zepeda, D., Popp, O., Qin, D., Teupser, D., Cox, J., Imhof, A., Küster, B., Lichtenthaler, S.F., Krijgsveld, J., Tenzer, S., Mertins, P., Coscia, F. and Hauck, S.M.
Journal of Proteome Research 24 (3): 1017-1029. 7 March 2025

Quality assurance in metabolomics and metabolic profiling.
Kirwan, J.A., Bruning, U. and Mosley, J.D.
Methods in Molecular Biology 2891 : 15-51. 16 January 2025

Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons.
Kroll, J., Kravčenko, U., Sadeghi, M., Diebolder, C.A., Ivanov, L., Lubas, M., Sprink, T., Schacherl, M., Kudryashev, M. and Rosenmund, C.
bioRxiv : 2025.02.11.635788. 12 February 2025

Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria.
Lachmann, G., Heeren, P., Schuster, F.S., Nyvlt, P., Spies, C., Feinkohl, I., Schenk, T., Ammouri, W., Debaugnies, F., Galicier, L., Jia, Y., Meena, N., Nagant, C., Neth, O., Nierkens, S., San Martin, J., Sun, H.W.L., Wang, Y., Wang, Z., Yoon, J.H., Brunkhorst, F.M., La Rosée, P., Janka, G. and Lachmann, C.
Journal of Internal Medicine 297 (3): 312-327. March 2025

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.
Latowska-Łysiak, J., Zarębska, Ż., Sajek, M.P., Grabowska, A., Buratin, A., Głodowicz, P., Misiorek, J.O., Kuczyński, K., Bortoluzzi, S., Żywicki, M., Kosiński, J.G., Rybak-Wolf, A., Piestrzeniewicz, R., Barciszewska, A.M. and Rolle, K.
Molecular Oncology 26 February 2025 (In Press)

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Lauer, S.M., Gasse, J., Krizsan, A., Reepmeyer, M., Sprink, T., Nikolay, R., Spahn, C.M.T. and Hoffmann, R.
Nature Communications 16 (1): 567. 10 January 2025

Cardiac MRI strain as an early indicator of myocardial dysfunction in hypertrophic cardiomyopathy.
Liu, S., Laghzali, O., Shalikar, S., Rusu, M.C., Carrier, L., Niendorf, T. and Ku, M.C.
International Journal of Molecular Sciences 26 (4): 1407. 7 February 2025

Calibration approaches for fluorescence lifetime applications using time-domain measurements.
Margineanu, A.
Methods in Microscopy 2 (1): 61-71. April 2025

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera, A., Compagnion, A.C., Pedicone, C., Janssen, M.K., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira, M., Beule, D., Mansuy-Aubert, V., Williams, T.L., Iraci, N., Sierra, A., Marro, S.G., Goate, A.M., Eggen, B.L., Kerr, W.G. and Paolicelli, R.C.
Immunity 58 (1): 197-217. 14 January 2025

Distinguishing transient from persistent brain structural changes in pediatric patients with acute disseminated encephalomyelitis.
Millward, J.M., Pilgrim, E., Baumann, M., Wendel, E.M., El Naggar, I., Bertolini, A., Bartels, F., Finke, C., Paul, F., Niendorf, T., Rostásy, K. and Waiczies, S.
Neurology Neuroimmunology & Neuroinflammation 12 (1): e200337. January 2025

Sex differences in the relationship of socioeconomic position with cardiovascular disease, cardiovascular risk factors and estimated cardiovascular disease risk: results of the German National Cohort.
Moreno Velásquez, I., Peters, S.A.E., Dragano, N., Greiser, K.H., Dörr, M., Fischer, B., Berger, K., Hannemann, A., Schnabel, R.B., Nauck, M., Göttlicher, S., Rospleszcz, S., Willich, S.N., Krist, L., Schulze, M.B., Günther, K., Brand, T., Schikowski, T., Emmel, C., Schmidt, B., Michels, K.B., Mikolajczyk, R., Kluttig, A., Harth, V., Obi, N., Castell, S., Klett-Tammen, C.J., Lieb, W., Becher, H., Winkler, V., Minnerup, H., Karch, A., Meinke-Franze, C., Leitzmann, M., Stein, M.J., Bohn, B., Schöttker, B., Trares, K., Peters, A. and Pischon, T.
Journal of the American Heart Association 14 (5): e038708. 4 March 2025

Short association fibres form topographic sheets in the human V1-V2 processing stream.
Movahedian Attar, F., Kirilina, E., Chaimow, D., Haenelt, D., Schneider, C., Edwards, L.J., Pine, K.J., Jäger, C., Reimann, K., Pohlmann, A., Periquito, J., Streubel, T., Trampel, R., Mohammadi, S., Niendorf, T., Morawski, M. and Weiskopf, N.
Imaging Neuroscience 3 : imag_a_00500. 10 March 2025

Quality assessment by bile composition in normothermic machine perfusion of rat livers.
Muth, V., Strobl, F., Michelotto, J., Gilles, L., Kirwan, J., Eisenberger, A., Marchand, J., Roschke, N., Moosburner, S., Pratschke, J., Sauer, I.M., Raschzok, N. and Gassner, J.M.G.V.
Tissue Engineering Part A 31 (5-6): 244-254. March 2025

SPINEPS-automatic whole spine segmentation of T2-weighted MR images using a two-phase approach to multi-class semantic and instance segmentation.
Möller, H., Graf, R., Schmitt, J., Keinert, B., Schön, H., Atad, M., Sekuboyina, A., Streckenbach, F., Kofler, F., Kroencke, T., Bette, S., Willich, S.N., Keil, T., Niendorf, T., Pischon, T., Endemann, B., Menze, B., Rueckert, D. and Kirschke, J.S.
European Radiology 35 (3): 1178-1189. March 2025

Socioeconomic characteristics and the home food environment are associated with feeding healthful and discretionary foods during the first year of life in the Pregnancy Eating Attributes Study.
Nansel, T.R., Lipsky, L.M., Schwedhelm, C., Faith, M.S. and Siega-Riz, A.M.
Journal of the Academy of Nutrition and Dietetics 125 (2): 228-238. February 2025

Herpesviruses mimic zygotic genome activation to promote viral replication.
Neugebauer, E., Walter, S., Tan, J., Drayman, N., Franke, V., van Gent, M., Pennisi, S., Veratti, P., Stein, K.S., Welker, I., Tay, S., Verjans, G.M.G.M., Timmers, H.T.M., Akalin, A., Landthaler, M., Ensser, A., Wyler, E. and Full, F.
Nature Communications 16 (1): 710. 16 January 2025

Magnetic resonance imaging of renal oxygenation.
Niendorf, T., Gladytz, T., Cantow, K., Millward, J.M., Waiczies, S. and Seeliger, E.
Nature Reviews Nephrology 23 April 2025 (In Press)

Senescent syncytiotrophoblast secretion during early onset preeclampsia.
Nonn, O., Debnath, O., Valdes, D.S., Sallinger, K., Secener, A.K., Fischer, C., Tiesmeyer, S., Nimo, J., Kuenzer, T., Ulrich, J., Maxian, T., Knöfler, M., Karau, P., Bartolomaeus, H., Kroneis, T., Frolova, A., Neuper, L., Haase, N., Malt, A., Müller-Bötticher, N., Kräker, K., Kedziora, S., Forstner, D., Eils, R., Schmidt-Ullrich, R., Haider, S., Verlohren, S., Stern, C., Sugulle, M., Jones, S., Thilaganathan, B., Kaitu'u-Lino, T.J., Tong, S., Huppertz, B., El-Heliebi, A., Staff, A.C., Coscia, F., Müller, D.N., Dechend, R., Gauster, M., Ishaque, N. and Herse, F.
Hypertension 82 (5): 787-799. May 2025

3D metamaterials facilitate human cardiac MRI at 21.0 Tesla: a proof-of-concept study.
Nurzed, B., Saha, N., Millward, J.M. and Niendorf, T.
Sensors 25 (3): 620. 21 January 2025

Alzheimer’s disease risk gene SORL1 promotes receptiveness of human microglia to pro-inflammatory stimuli.
Ovesen, P.L., Juul-Madsen, K., Telugu, N.S., Schmidt, V., Frahm, S., Radbruch, H., Louth, E.L., Korshoej, A.R., Heppner, F.L., Diecke, S., Kettenmann, H. and Willnow, T.E.
Glia 73 (4): 857-872. April 2025

Scoping Review zu Gesundheitszustand, -verhalten und subjektiven Belastungsempfinden von Pflegekräften in Deutschland: ein Protokoll [Scoping review on health status, behavior, and perceived stress of nursing staff in Germany: a protocol].
Pecha, S., Brinks, R. and Feinkohl, I.
Pravention und Gesundheitsforderung 31 March 2025 (In Press)

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment.
Pentimalli, T.M., Schallenberg, S., León-Periñán, D., Legnini, I., Theurillat, I., Thomas, G., Boltengagen, A., Fritzsche, S., Nimo, J., Ruff, L., Dernbach, G., Jurmeister, P., Murphy, S., Gregory, M.T., Liang, Y., Cordenonsi, M., Piccolo, S., Coscia, F., Woehler, A., Karaiskos, N., Klauschen, F. and Rajewsky, N.
Cell Systems : 101261. 11 April 2025 (In Press)

The baseline examinations of the German National Cohort (NAKO): recruitment protocol, response, and weighting.
Rach, S., Sand, M., Reineke, A., Becher, H., Greiser, K.H., Wolf, K., Wirkner, K., Schmidt, C.O., Schipf, S., Jöckel, K.H., Krist, L., Ahrens, W., Brenner, H., Castell, S., Gastell, S., Harth, V., Holleczek, B., Ittermann, T., Janisch-Fabian, S., Karch, A., Keil, T., Klett-Tammen, C.J., Kluttig, A., Kuß, O., Leitzmann, M., Lieb, W., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Moreno Velásquez, I., Obi, N., Övermöhle, C., Peters, A., Pischon, T., Rospleszcz, S., Schmidt, B., Schulze, M.B., Stang, A., Teismann, H., Töpfer, C., Wolff, R. and Günther, K.
European Journal of Epidemiology 22 April 2025 (In Press)

Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort.
Reichmann, R., Nimptsch, K., Pischon, T., Gunter, M.J., Jenab, M., Eriksen, A.K., Tjonneland, A., Janke, J., Katzke, V., Kaaks, R., Schulze, M.B., Eichelmann, F., Masala, G., Sieri, S., Pasanisi, F., Tumino, R., Giraudo, M.T., Rothwell, J., Severi, G., Jakszyn, P., Sanchez-Perez, M.J., Amiano, P., Colorado-Yohar, S.M., Guevara, M., van Guelpen, B., Aglago, E.K., Heath, A.K., Smith-Byrne, K., Weiderpass, E. and Aleksandrova, K.
International Journal of Cancer 156 (5): 930-942. 1 March 2025

Genetic alterations, therapy response, and survival among patients with triple-negative breast cancer: a secondary analysis of a randomized clinical trial.
Richters, L., Gluz, O., Weber-Lassalle, N., Christgen, M., Haverkamp, H., Kuemmel, S., Kayali, M., Kates, R.E., Grischke, E.M., Altmüller, J., Forstbauer, H., Thiele, H., Braun, M., Warm, M., Ossowski, A., Wuerstlein, R., Ernst, C., Graeser, M., Linn, S.C., Nitz, U., Hauke, J., Kreipe, H.H., Schmutzler, R.K., Hahnen, E. and Harbeck, N.
JAMA Network Open 8 (2): e2461639. February 2025

Dental and oral health assessments in the German National Cohort (NAKO).
Samietz, S., Borof, K., Hertrampf, K., Aarabi, G., Ciardo, A., Finke, H., Hagenfeld, D., Kühnisch, J., Rütters, M., Baumeister, S.E., Reckelkamm, S.L., Kim, T.S., Kocher, T., Ahrens, W., Brenner, H., Emmel, C., Fischer, B., Führer, A., Greiser, K.H., Grischke, J., Günther, K., Harth, V., Jaskulski, S., Karch, A., Keil, T., Kemmling, Y., Kluttig, A., Krist, L., Kuss, O., Leitzmann, M., Meinke-Franze, C., Michels, K.B., Obi, N., Peters, A., Pischon, N., Pischon, T., Schipf, S., Schmidt, B., Teismann, H., Rupf, S. and Holtfreter, B.
BMC Oral Health 25 (1): 149. 28 January 2025

Identification and characterization of highly potent and isoenzyme-selective inhibitors of deiodinase type I via a nonradioactive high-throughput screening method.
Sane, R., Seyffarth, C., Kleissle, S., Neuenschwander, M., von Kries, J.P., Frädrich, C., Renko, K., Wirth, E.K. and Köhrle, J.
Thyroid 2 April 2025 (In Press)

Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO).
Stein, M.J., Weber, A., Bamberg, F., Baurecht, H., Berger, K., Bohmann, P., Brenner, H., Brummer, J., Dörr, M., Fischer, B., Gastell, S., Greiser, K.H., Harth, V., Hebestreit, A., Heise, J.K., Herbolsheimer, F., Ittermann, T., Karch, A., Keil, T., Kluttig, A., Krist, L., Michels, K.B., Mikolajczyk, R., Nauck, M., Nimptsch, K., Obi, N., Pischon, T., Pivovarova-Ramich, O., Schikowski, T., Schmidt, B., Schulze, M.B., Steindorf, K., Zylla, S. and Leitzmann, M.F
International Journal of Obesity 24 January 2025 (In Press)

Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.
Tchouto, M.N., Bucher, C.H., Mess, A.K., Haas, S., Schmidt-Bleek, K., Duda, G.N., Beule, D. and Milek, M.
Frontiers in Immunology 16 : 1511902. 3 March 2025

A novel approach to modelling acute cardiac decompensation in rats.
Thiele, A., Bartolomaeus, H., Anandakumar, H., Haase, N., Heuser, A., Müller, D.N., Dechend, R. and Wilck, N.
Cardiovascular Research 121 (3): cvae268. February 2025

3D epigenome evolution underlies divergent gene regulatory programs in primate neural development.
Vangelisti, S., Chong, F., Dietl, T., Zywitza, V., Diecke, S., Enard, W. and Bonev, B.
bioRxiv : 2025.03.11.642620. 12 March 2025

Depressive symptoms, education, gender and history of migration - an intersectional analysis using data from the German National Cohort (NAKO).
Vonneilich, N., Becher, H., Berger, K., Bohmann, P., Brenner, H., Castell, S., Dragano, N., Harth, V., Jaskulski, S., Karch, A., Keil, T., Krist, L., Lange, B., Leitzmann, M., Massag, J., Meinke-Franze, C., Mikolajczyk, R., Obi, N., Pischon, T., Reuter, M., Schmidt, B., Moreno Velásquez, I., Völzke, H., Wiessner, C., von dem Knesebeck, O. and Lüdecke, D.
International Journal for Equity in Health 24 (1): 108. 21 April 2025

Cytokine-armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56(dim)CD16(dim) natural killer cells.
Wang, R., Hu, M., Lozzi, I., Jin, C.Z.J., Ma, D., Splith, K., Mengwasser, J., Wolf, V., Feldbrügge, L., Tang, P., Timmermann, L., Hillebrandt, K.H., Kirchner, M., Mertins, P., Hilfenhaus, G., Neumann, C.C.M., Kammertoens, T., Pratschke, J., Malinka, T., Sauer, I.M., Noessner, E., Guo, Z.S. and Felsenstein, M.
International Journal of Cancer 156 (3): 638-651. 1 February 2025

TERT expression and clinical outcome in pulmonary carcinoids.
Werr, L., Bartenhagen, C., Rosswog, C., Cartolano, M., Voegele, C., Sexton-Oates, A., Di Genova, A., Ernst, A., Kahlert, Y., Hemstedt, N., Höppner, S., Mansuet Lupo, A., Pelosi, G., Brcic, L., Papotti, M., George, J., Bosco, G., Quaas, A., Tang, L.H., Robzyk, K., Kadota, K., Roh, M.S., Fanaroff, R.E., Falcon, C.J., Büttner, R., Lantuejoul, S., Rekhtman, N., Rudin, C.M., Travis, W.D., Alcala, N., Fernandez-Cuesta, L., Foll, M., Peifer, M., Thomas, R.K. and Fischer, M.
Journal of Clinical Oncology 43 (2): 214-225. 10 January 2025

Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.
Wiechert, F., Unbehaun, A., Sprink, T., Seibel, H., Bürger, J., Loerke, J., Mielke, T., Diebolder, C.A., Schacherl, M. and Spahn, C.M.T.
Nucleic Acids Research 53 (1): gkae1191. 13 January 2025

Complex human hair bearing skin organoids as model for herpes simplex virus 1 infection in the skin.
Wyler, E., Albertini, S., Friedel, C.C., Manukyan, A., Huang, J., Krasemann, S., Plumbon, I., Altmüller, J., Conrad, T., Radbruch, H., Hafezi, W., Hansen, A., Grundhoff, A., Landthaler, M., Fischer, N. and Czech-Sioli, M.
bioRxiv : 2025.02.10.637415. 11 February 2025

Neuromuscular dysfunction in patient-derived FUS(R244RR)-ALS iPSC model via axonal downregulation of neuromuscular junction proteins.
von Kügelgen, N., Ludwik, K.A., Mendonsa, S., Römer, C., Becher, E., Breimann, L., Strauch, M., Mari, T., Mongellaz, S., Zuckerman, B., Efendic, F., Grexa, N., Oliveras-Martinez, A., Woehler, A., Selbach, M., La Bella, V., Ulitsky, I. and Chekulaeva, M.
NAR Molecular Medicine 2 (2): ugaf005. April 2025

2024

Enhancing biomarker-based oncology trial matching using large language models.
Al Khoury, N., Shaik, M., Wurmus, R. and Akalin, A.
bioRxiv : 2024.09.13.612922. 19 September 2024

Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin.
Al-Diab, O., Sünkel, C., Blanc, E., Catar, R.A., Ashraf, M.I., Zhao, H., Wang, P., Rinschen, M.M., Fritsche-Guenther, R., Grahammer, F., Bachmann, S., Beule, D., Kirwan, J.A., Rajewsky, N., Huber, T.B., Gürgen, D. and Kusch, A.
Biology of Sex Differences 15 (1): 72. 15 September 2024

Single-nucleus and spatial transcriptome reveal adrenal homeostasis in normal and tumoural adrenal glands.
Altieri, B., Secener, A.K., Sai, S., Fischer, C., Sbiera, S., Arampatzi, P., Kircher, S., Herterich, S., Landwehr, L.S., Vitcetz, S.N., Braeuning, C., Fassnacht, M., Ronchi, C.L. and Sauer, S.
Clinical and Translational Medicine 14 (8): e1798. August 2024

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome.
Arlt, F.A., Breuer, A., Trampenau, E., Boesl, F., Kirchner, M., Mertins, P., Sánchez-Sendín, E., Nasouti, M., Mayrhofer, M., Blüthner, M., Endres, M., Prüss, H. and Franke, C.
Frontiers in Immunology 15 : 1404800. 2 August 2024

Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibition in colorectal cancer.
Aust, O., Blanc, E., Lüthen, M., Hollek, V., Astaburuaga-García, R., Klinger, B., Trinks, A., Beule, D., Papke, B., Horst, D., Blüthgen, N., Sers, C., Der, C.J. and Morkel, M.
bioRxiv : 2024.07.01.601542v2. 12 July 2024

A homozygous nonsense mutation identified in COL7A1 in a family with autosomal recessive dystrophic epidermolysis bullosa.
Ayub, M., Xiong, X., Anwer, S., Altmüller, J., Naeem, M., Hassan, N., Khan, K., Motameny, S., Khaliq, S., Rehman, F.U., Uddin, S.A., Wali, A., Betz, R. and Basit, S.
Journal of Medicine and Life 17 (9): 892-896. 9 September 2024

In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia.
Bakina, O., Conrad, T., Mitic, N., Vidal, R.O., Obrusnik, T., Sai, S., Nolte, C., Semtner, M. and Kettenmann, H.
PLoS ONE 19 (7): e0302376. 11 July 2024

Baseline MRI examination in the NAKO health study - findings on feasibility, participation and dropout rates, comfort, and image quality.
Bamberg, F., Schlett, C.L., Caspers, S., Ringhof, S., Günther, M., Hirsch, J.G., Rüdebusch, J., Miklánková, P., Bittner, N., Jockwitz, C., Forsting, M., Hosten, N., Kaaks, R., Kauczor, H.U., Kroenke, T., Niendorf, T., Peters, A., Pischon, T., Stang, A., Berger, K. and Völzke, H.
Deutsches Arzteblatt International 121 (18): 587-593. 6 September 2024

Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues.
Bauersachs, D., Bomholtz, L., Del Ray Mateos, S., Kühn, R. and Lisowski, P.
Frontiers in Neuroscience 18 : 1426177. 6 June 2024

Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15 (1): 2611. 23 March 2024

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14 (3): 492-507. 1 March 2024

SoccHealth: a health status examination of former professional football (soccer) players within the German National Cohort.
Berger, K., Baurecht, H., Stein, M., Heise, J.K., Castell, S., Weisser, L., Schikowski, T., Oliver, K., Lieb, W., Micolajczyk, R., Kluttig, A., Schmitt, B., Stang, A., Pischon, T., Peters, A., Brenner, H., Leitzmann, M., Krist, L., Keil, T., Karch, A. and Meyer, T.
BMJ Open Sport & Exercise Medicine 10 (4): e002228. 1 October 2024

Enhancing variant prioritization in VarFish through on-premise computational facial analysis.
Bhasin, M.A., Knaus, A., Incardona, P., Schmid, A., Holtgrewe, M., Elbracht, M., Krawitz, P.M. and Hsieh, T.C.
Genes 15 (3): 370. March 2024

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cells.
Boehm, V., Wallmeroth, D., Wulf, P.O., Teixeira Alves, L.G., Popp, O., Riedel, M., Wyler, E., Franitza, M., Gerbracht, J.V., Becker, K., Polkovnychenko, K., Del Giudice, S., Benlasfer, N., Mertins, P., Landthaler, M. and Gehring, N.H.
bioRxiv : 2024.03.04.583328. 8 March 2024

Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence.
Boeing, H., Amini, A.M., Haardt, J., Schmidt, A., Bischoff-Ferrari, H.A., Buyken, A.E., Egert, S., Ellinger, S., Kroke, A., Lorkowski, S., Louis, S., Nimptsch, K., Schulze, M.B., Schutkowski, A., Schwingshackl, L., Siener, R., Zittermann, A., Watzl, B. and Stangl, G.I.
European Journal of Nutrition 63 (4): 1041-1058. June 2024

Cognitive reserve and the risk of postoperative neurocognitive disorders in older age.
Borchers, F., Rumpel, M., Laubrock, J., Spies, C., Kozma, P., Slooter, A., van Montfort, S.J.T., Piper, S.K., Wiebach, J., Winterer, G., Pischon, T. and Feinkohl, I.
Frontiers in Aging Neuroscience 15 : 1327388. 5 February 2024

Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling.
Brauer, E., Herrera, A., Fritsche-Guenther, R., Görlitz, S., Leemhuis, H., Knaus, P., Kirwan, J.A., Duda, G.N. and Petersen, A.
Biomaterials 309 : 122614. September 2024

ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow, C., Thery, F., Wirth, E.K., Ochs, S., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A.
Cardiovascular Research 120 (6): 644-657. 6 April 2024

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M., Serve, S., Marx, A.F., Fadejeva, J., Saikali, P., Dzamukova, M., Durán-Hernández, N., Kommer, C., Heinrich, F., Durek, P., Heinz, G.A., Höfer, T., Mashreghi, M.F., Kühn, R., Pinschewer, D.D. and Löhning, M.
Nature Immunology 25 (2): 256-267. February 2024

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome.
Busley, A.V., Gutiérrez-Gutiérrez, Ó., Hammer, E., Koitka, F., Mirzaiebadizi, A., Steinegger, M., Pape, C., Böhmer, L., Schroeder, H., Kleinsorge, M., Engler, M., Cirstea, I.C., Gremer, L., Willbold, D., Altmüller, J., Marbach, F., Hasenfuss, G., Zimmermann, W.H., Ahmadian, M.R., Wollnik, B. and Cyganek, L.
Cell Reports 43 (7): 114448. 23 July 2024

Depression, anxiety and cognitive function in persons with inflammatory rheumatic diseases: cross-sectional results from the German National Cohort (NAKO).
Callhoff, J., Berger, K., Albrecht, K. and Strangfeld, A.
RMD Open 10 (4): e004808. 23 October 2024

Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135 (6): 671-684. 30 August 2024

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.
Cao, Y., Popp, O., Milani, N., Qadri, F., Kühn, R., Mertins, P., Bader, M. and Alenina, N.
Communications Biology 7 (1): 1641. 18 December 2024

SRRM2 splicing factor modulates cell fate in early development.
Carvalho, S., Zea-Redondo, L., Tang, T.C.C., Stachel-Braum, P., Miller, D., Caldas, P., Kukalev, A., Diecke, S., Grosswendt, S., Grosso, A.R. and Pombo, A.
Biology Open 13 (4): bio060415. April 2024

miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner.
Cerda Jara, C.A., Kim, S.J., Thomas, G., Farsi, Z., Zolotarov, G., Dube, G., Deter, A., Bahry, E., Georgii, E., Woehler, A., Piwecka, M. and Rajewsky, N.
EMBO Reports 25 (7): 3039. July 2024

A point-of-research decision in synovial tissue engineering: Mesenchymal stromal cells, tissue derived fibroblast or CTGF-mediated mesenchymal-to-fibroblast transition.
Damerau, A., Kirchner, M., Mertins, P., Buttgereit, F. and Gaber, T.
European Journal of Cell Biology 103 (4): 151455. December 2024

Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments.
Demirci, H., Popovic, S., Dittmayer, C., Yilmaz, D.E., El-Shimy, I.A., Mülleder, M., Hinze, C., Su, M., Mertins, P., Kirchner, M., Osmanodja, B., Paliege, A., Budde, K., Amann, K., Persson, P.B., Mutig, K. and Bachmann, S.
Acta Physiologica 240 (8): e14190. August 2024

Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly.
Dick, A., Mikirtumov, V., Fuchs, J., Krupp, F., Olal, D., Bendl, E., Sprink, T., Diebolder, C., Kudryashev, M., Kochs, G., Roske, Y. and Daumke, O.
Structure 32 (8): 1068-1078. 8 August 2024

Adhesion of pancreatic tumor cell clusters by desmosomal molecules enhances early liver metastases formation.
Dietrich, N., Castellanos-Martinez, R., Kemmling, J., Heuser, A., Schnoor, M., Schinner, C. and Spindler, V.
Scientific Reports 14 (1): 18189. 6 August 2024

T- and L-type calcium channels maintain calcium oscillations in the murine zona glomerulosa.
Dinh, H.A., Volkert, M., Secener, A.K., Scholl, U.I. and Stölting, G.
Hypertension 81 (4): 811-822. April 2024

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control.
Dobner, J., Diecke, S., Krutmann, J., Prigione, A. and Rossi, A.
Nature Communications 15 (1): 8547. 2 October 2024

Partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy in mice lacking thyroid hormone receptor β.
Dore, R., Sentis, S.C., Johann, K., Lopez-Alcantara, N., Resch, J., Chandrasekar, A., Müller-Fielitz, H., Moeller, L.C., Fuehrer, D., Schwaninger, M., Obermayer, B., Opitz, R. and Mittag, J.
Thyroid 34 (6): 796-805. June 2024

3D spheroid and organoid models to study neuroinfection of RNA viruses.
Dos Reis, V.P., Cirksena, K., Rybak-Wolf, A., Seeger, B., Herker, E. and Gerold, G.
Methods in Molecular Biology 2824 : 409-424. August 2024

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2.
Ehlers, L., Hombrouck, A., Wouters, M., Pillay, B., Delafontaine, S., Bucciol, G., Baggio, M., Dzhus, M., Ebstein, F., Jacquemyn, M., De Somer, L., Schrijvers, R., Vanderschueren, S., Cassiman, D., Kirchner, M., Mertins, P., Mashreghi, M.F., Kallinich, T., Daelemans, D., Agostinis, P., Moens, L. and Meyts, I.
bioRxiv : 2023.10.25.564037v3. 8 October 2024

preon: fast and accurate entity normalization for drug names and cancer types in precision oncology.
Ermshaus, A., Piechotta, M., Rüter, G., Keilholz, U., Leser, U. and Benary, M.
Bioinformatics 40 (3): btae085. March 2024

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.
Essex, M., Millet Pascual-Leone, B.L., Löber, U., Kuhring, M., Zhang, B., Brüning, U., Fritsche-Guenther, R., Krzanowski, M., Fiocca Vernengo, F., Brumhard, S., Röwekamp, I., Bielecka, A.A., Lesker, T.R., Wyler, E., Landthaler, M., Mantei, A., Meisel, C., Caesar, S., Thibeault, C., Corman, V.M., Marko, L., Suttorp, N., Strowig, T., Kurth, F., Sander, L.E., Li, Y., Kirwan, J.A., Forslund, S.K. and Opitz, B.
NPJ Biofilms and Microbiomes 10 (1): 66. 1 August 2024

Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease.
Essex, M., Rios Rodriguez, V., Rademacher, J., Proft, F., Löber, U., Marko, L., Pleyer, U., Strowig, T., Marchand, J., Kirwan, J.A., Siegmund, B., Forslund, S.K. and Poddubnyy, D.
Arthritis & Rheumatology 76 (1): 48-58. January 2024

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani, I., Petragnano, F., Wang, Z., Edwards, R., Telugu, N., Pietrantoni, I., Zabel, U., Zauber, H., Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Pohl, B., Aringhieri, S., Carli, M., Aloisi, G., Marampon, F., Charlesworth, E., Roman, A., Diecke, S., Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Rossi, M., Lohse, M.J., Annibale, P. and Maggio, R.
PLoS Biology 22 (4): e3002582. 29 April 2024

Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova, D., Fritsch, V.N., Siebert, K., Methling, K., Lalk, M., Busche, T., Kalinowski, J., Weiner, J., Beule, D., Bertrams, W., Kohler, T.P., Hammerschmidt, S., Löwa, A., Fischer, M., Mieth, M., Hellwig, K., Frey, D., Neudecker, J., Rueckert, J.C., Toennies, M., Bauer, T.T., Graff, M., Tran, H.L., Eggeling, S., Gruber, A.D., Antelmann, H., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 64 (6): 2301983. December 2024

Determinants of ascending aortic morphology: Cross-sectional deep learning-based analysis on 25,073 non-contrast-enhanced MRI of NAKO.
Fay, L., Hepp, T., Winkelmann, M.T., Peters, A., Heier, M., Niendorf, T., Pischon, T., Endemann, B., Schulz-Menger, J., Krist, L., Schulze, M.B., Mikolajczyk, R., Wienke, A., Obi, N., Silenou, B.C., Lange, B., Kauczor, H.U., Lieb, W., Baurecht, H., Leitzmann, M., Trares, K., Brenner, H., Michels, K.B., Jaskulski, St., Völzke, H., Nikolaou, K., Schlett, C.L., Bamberg, F., Lescan, M., Yang, B., Küstner, T. and Gatidis, S.
medRxiv : 2024.07.12.24310356. 15 July 2024

The association of plasma leptin, soluble leptin receptor and total and high-molecular weight adiponectin with the risk of perioperative neurocognitive disorders.
Feinkohl, I., Janke, J., Slooter, A.J.C., Winterer, G., Spies, C. and Pischon, T.
American Journal of Geriatric Psychiatry 32 (9): 1119-1129. September 2024

Systemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the blood proteome.
Fentker, K., Kirchner, M., Ziehm, M., Niquet, S., Popp, O., Duerr, J., Schaupp, L., Roehmel, J., Thee, S., Haemmerling, S., Sommerburg, O., Stahl, M., Graeber, S.Y., Mall, M.A. and Mertins, P.
bioRxiv : 2024.10.18.619058. 18 October 2024

Feasibility analysis of using patient-derived tumour organoids for treatment decision guidance in locally advanced head and neck squamous cell carcinoma.
Fischer, A.S., Pestana, A., Sachse, V., Doll, C., Hofmann, E., Heiland, M., Obermueller, T., Heidemann, J., Dommerich, S., Schoppe, D., Schallenberg, S., Piwonski, I., Blanc, E. and Tinhofer, I.
European Journal of Cancer 213 : 115100. December 2024

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Flügel, T., Schacherl, M., Unbehaun, A., Schroeer, B., Dabrowski, M., Bürger, J., Mielke, T., Sprink, T., Diebolder, C.A., Guillén Schlippe, Y.V. and Spahn, C.M.T.
Nature Communications 15 (1): 1756. 26 February 2024

Ide copy number variant does not influence lesion size and mortality in two C57BL/6J mouse models of cerebrovascular ischemia nor in human cerebrovascular disease. An exploratory study.
Foddis, M., Blumenau, S., Mueller, S., Messerschmidt, C., Rocca, C., Pagnamenta, A.T., Winek, K., Endres, M., Meisel, A., Tucci, A., Bras, J., Guerreiro, R., Beule, D., Dirnagl, U. and Sassi, C.
bioRxiv : 2024.05.15.593342. 16 May 2024

L-glyceraldehyde inhibits neuroblastoma cell growth via a multi-modal mechanism on metabolism and Signaling.
Forbes, M., Kempa, R., Mastrobuoni, G., Rayman, L., Pietzke, M., Bayram, S., Arlt, B., Spruessel, A., Deubzer, H.E. and Kempa, S.
Cancers 16 (9): 1664. May 2024

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis.
Frueh, J.T., Campe, J., Sunaga-Franze, D.Y., Verheyden, N.A., Ghimire, S., Meedt, E., Haslinger, D., Harenkamp, S., Staudenraus, D., Sauer, S., Kreft, A., Schubert, R., Lohoff, M., Krueger, A., Bonig, H., Chiocchetti, A.G., Zeiser, R., Holler, E. and Ullrich, E.
OncoImmunology 13 (1): 2296712. 2024

Evaluating large language model workflows in clinical decision support: referral, triage, and diagnosis.
Gaber, F., Shaik, M., Franke, V. and Akalin, A.
medRxiv : 2024.09.27.24314505. 28 September 2024

Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline.
Galteau, M.E., Broadwater, M., Chen, Y., Desrosiers-Gregoire, G., Gil, R., Kaesser, J., Kim, E., Kiryagdi, P., Lambers, H., Liu, Y.Y., Lopez-Gil, X., MacNicol, E., Mohebkhodaei, P., De Oliveira, R.X.N., Pereira, C.A., Reimann, H.M., Rivera-Olvera, Al., Selingue, E., Sirmpilatze, N., Strobelt, S., Sumiyoshi, A., Tham, C., Tudela, R., Vrooman, R.M., Wank, I., Zhang, Y., van Engelenburg, W.A., Baudewig, J., Boretius, S., Cash, D., Chakravarty, M.M., Chuang, K.H., Ciobanu, L., Devenyi, G.A., Faber, C., Hess, A., Homberg, J.R., Jelescu, I.O., Justicia, C., Kawashima, R., Niendorf, T., Scheenen, T.W.J., Shemesh, N., Soria, G., Todd, N., Wachsmuth, L., Yu, X., Zhang, B.B., Shih, Y.Y.I., Lee, S.H. and Grandjean, J.
bioRxiv : 2024.09.27.615384. 30 September 2024

Mechanical strain activates planar cell polarity signaling to coordinate vascular cell dynamics.
Golbach, L., Saha, T., Odenthal-Schnittler, M., Lücking, J., Velic, A., Akmeric, E.B., Bornhorst, D., Popp, O., Mertins, P., Gunawan, F., Gerhardt, H., Macek, B., Trappmann, B., Schnittler, H.J., Galic, M. and Matis, M.
bioRxiv : 2024.06.25.600357. 26 June 2024

Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo.
Gomez, J.M., Nolte, H., Vogelsang, E., Dey, B., Takeda, M., Giudice, G., Faxel, M., Haunold, T., Cepraga, A., Zinzen, R.P., Krüger, M., Petsalaki, E., Wang, Y.C. and Leptin, M.
eLife 13 : e99263. 3 October 2024

Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel.
Greda, A.K., Gomes, J.P., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.M., Telugu, N.S., Cömert, C., Kirwan, J., Kunz, S., Rothe, M., Diecke, S., Bross, P. and Willnow, T.E.
bioRxiv : 2024.06.10.598173. 10 June 2024

CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment.
Greensmith, R., Lape, I.T., Riella, C.V., Schubert, A.J., Metzger, J.J., Dighe, A.S., Tan, X., Hemmer, B., Rau, J., Wendlinger, S., Diederich, N., Schütz, A., Riella, L.V. and Kaminski, M.M.
EMBO Molecular Medicine 16 (10): 2619-2637. 14 October 2024

Comparing the extraction performance in mouse plasma of different biphasic methods for polar and nonpolar compounds.
Gutmann, F., Fritsche-Guenther, R., Dias, D.B. and Kirwan, J.A.
Journal of Proteome Research 23 (8): 2961-2969. 2 August 2024

Generation of two isogenic human iPSC lines (ZIPi013-B-1, ZIPi013-B-2) carrying a CRISPR/Cas9-mediated deletion of TRPM4.
Haferkamp, U., Telugu, N., Krieg, K., Schaefer, W., Lam, D., Binkle-Ladisch, L., Friese, M.A., Diecke, S. and Pless, O.
Stem Cell Research 81 : 103609. December 2024

Personality and the use of cancer screenings - results of the German National Cohort.
Hajek, A., Becher, H., Brenner, H., Holleczek, B., Katzke, V., Kaaks, R., Minnerup, H., Karch, A., Baurecht, H., Leitzmann, M., Peters, A., Gastell, S., Ahrens, W., Haug, U., Nimptsch, K., Pischon, T., Michels, K.B., Dorrn, A., Klett-Tammen, C., Castell, S., Willich, S.N., Keil, T., Schipf, S., Meinke-Franze, C., Harth, V., Obi, N. and König, H.H.
Preventive Medicine Reports 41 : 102677. May 2024

MR beyond diagnostics at the ESMRMB annual meeting: MR theranostics and intervention.
Hajek, M., Flögel, U., Tavares, A., Nichelli, L., Kennerley, A., Kahn, T., Futterer, J., Firsiori, A., Grüll, H., Saha, N., Couñago, F., Aydogan, D.B., Caligiuri, M.E., Faber, C., Bell, L.C., Figueiredo, P., Vilanova, J.C., Santini, F., Mekle, R. and Waiczies, S.
Magnetic Resonance Materials in Physics, Biology and Medicine 37 (3): 323-328. July 2024

p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10 (43): eadp8783. 25 October 2024

Characterization of two iPSC lines from patients with maternally inherited leigh (MILS) and neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome carrying the MT-ATP6 m.8993 T>G mutation at different degrees of heteroplasmy.
Haschke, A.M., Diecke, S. and Schuelke, M.
Stem Cell Research 81 : 103547. December 2024

The effects of hypoxia on the immune-metabolic interplay in liver cancer.
He, Y., Xu, H., Liu, Y., Kempa, S., Vechiatto, C., Schmidt, R., Yilmaz, E.Y., Heidemann, L., Schnorr, J., Metzkow, S., Schellenberger, E., Häckel, A., Patzak, A., Müller, D.N. and Savic, L.J.
Biomolecules 14 (8): 1024. 17 August 2024

Circulating tumor DNA sequencing for biologic classification and individualized risk stratification in patients with Hodgkin Lymphoma.
Heger, J.M., Mammadova, L., Mattlener, J., Sobesky, S., Cirillo, M., Altmüller, J., Kirst, E., Reinke, S., Klapper, W., Bröckelmann, P.J., Ferdinandus, J., Kaul, H., Schneider, G., Schneider, J., Schleifenbaum, J.K., Ullrich, R.T., Freihammer, M., Awerkiew, S., Lohmann, M., Klein, F., Nürnberg, P., Hallek, M., Rossi, D., Mauz-Körholz, C., Gattenlöhner, S., Bräuninger, A., Borchmann, P., von Tresckow, B. and Borchmann, S.
Journal of Clinical Oncology 42 (35): 4218-4230. 10 December 2024

Perioperative levels of IL8 and IL18, but not IL6, are associated with nucleus basalis magnocellularis atrophy three months after surgery.
Heinrich, M., Spies, C., Borchers, F., Feinkohl, I., Pischon, T., Slooter, A.J.C., von Haefen, C., Zacharias, N., Winterer, G. and Lammers-Lietz, F.
Journal of Neuroimmune Pharmacology 19 (1): 10. 14 March 2024

Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).
Holz, A., Obi, N., Ahrens, W., Berger, K., Bohn, B., Brenner, H., Fischer, B., Fricke, J., Führer, A., Gastell, S., Greiser, K.H., Harth, V., Heise, J.K., Holleczek, B., Keil, T., Klett-Tammen, C.J., Leitzmann, M., Lieb, W., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Nimptsch, K., Peters, A., Pischon, T., Riedel, O., Schikowski, T., Schipf, S., Schmidt, B., Schulze, M.B., Stang, A., Hellwig, K., Riemann-Lorenz, K., Heesen, C. and Becher, H.
BMC Neurology 24 : 123. 13 April 2024

REEV: review, evaluate and explain variants.
Hramyka, D., Sczakiel, H.L., Zhao, M.X., Stolpe, O., Nieminen, M., Adam, R., Danyel, M., Einicke, L., Hägerling, R., Knaus, A., Mundlos, S., Schwartzmann, S., Seelow, D., Ehmke, N., Mensah, M.A., Boschann, F., Beule, D. and Holtgrewe, M.
Nucleic Acids Research 52 (W1): W148-W158. 5 July 2024

Quantification of myocardial effective transverse relaxation time with magnetic resonance at 7.0 Tesla for a better understanding of myocardial (patho)physiology.
Huelnhagen, T., Serradas-Duarte, T., Hezel, F., Paul, K. and Niendorf, T.
In: Quantification of Biophysical Parameters in Medical Imaging. Springer, Cham, Switzerland, 381-406. ISBN 978-3-031-61846-8 5 November 2024

Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Ihlow, J., Penter, L., Vuong, L.G., Bischoff, P., Obermayer, B., Trinks, A., Blau, O., Behnke, A., Conrad, T., Morkel, M., Wu, C.J., Westermann, J., Bullinger, L., von Brünneck, A.C., Blüthgen, N., Horst, D. and Praktiknjo, S.D.
Med 6 (4): 100548. 11 April 2024

Extensive folding variability between homologous chromosomes in mammalian cells.
Irastorza-Azcarate, I., Kukalev, A., Kempfer, R., Thieme, C.J., Mastrobuoni, G., Markowski, J., Loof, G., Sparks, T.M., Brookes, E., Natarajan, K.N., Sauer, S., Fisher, A.G., Nicodemi, M., Ren, B., Schwarz, R.F., Kempa, S. and Pombo, A.
bioRxiv : 2024.05.08.591087. 10 May 2024

Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D., Knapstein, P.R., Otto, E., Köhli, P., Sevecke, J., Graef, F., Graffmann, C., Fuchs, M., Jiang, S., Rickert, M., Erdmann, C., Appelt, J., Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G., Xie, W., Donat, A., Schinke, T., Ivanov, A., Tchouto, M.N., Beule, D., Frosch, K.H., Baranowsky, A., Tsitsilonis, S. and Keller, J.
Science Translational Medicine 16 (743): eadk9129. 17 April 2024

The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression.
Jamil, M. A., Al-Rifai, R., Nuesgen, N., Altmüller, J., Oldenburg, J. and El-Maarri, O.
Frontiers in Genetics 15 : 1302685. 19 February 2024

Quantifying model uncertainty for semantic segmentation of Fluorine-19 MRI using stochastic gradient MCMC.
Javanbakhat, M., Starke, L., Waiczies, S. and Lippert, C.
Computer Vision and Image Understanding 241 : 103967. April 2024

scMaui: a widely applicable deep learning framework for single-cell multiomics integration in the presence of batch effects and missing data.
Jeong, Y., Ronen, J., Kopp, W., Lutsik, P. and Akalin, A.
BMC Bioinformatics 25 (1): 257. 6 August 2024

Use of mesna prophylaxis in patients with cyclophosphamide-treated ANCA-associated vasculitis: cross-sectional survey of practitioners.
Joos, L., Gonzalez Chiappe, S., Neumann, T. and Mahr, A.
Rheumatology International 44 (12): 3099-3106. December 2024

Deep learning-based body composition analysis from whole-body magnetic resonance imaging to predict all-cause mortality in a large western population.
Jung, M., Raghu, V.K., Reisert, M., Rieder, H., Rospleszcz, S., Pischon, T., Niendorf, T., Kauczor, H.U., Völzke, H., Bülow, R., Russe, M.F., Schlett, C.L., Lu, M.T., Bamberg, F. and Weiss, J.
EBioMedicine 110 : 105467. December 2024

Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10 (12): eadl1710. 22 March 2024

Automated quality control of small animal MR neuroimaging data.
Kalantari, A., Shahbazi, M., Schneider, M., Raikes, A.C., Frazão, V.V., Bhattrai, A., Carnevale, L., Diao, Y., Franx, B.A.A., Gammaraccio, F., Goncalves, L.M., Lee, S., van Leeuwen, E.M., Michalek, A., Mueller, S., Olvera, A.R., Padro, D., Selim, M.K., van der Toorn, A., Varriano, F., Vrooman, R., Wenk, P., Albers, H.E., Boehm-Sturm, P., Budinger, E., Canals, S., De Santis, S., Brinton, R.D., Dijkhuizen, R.M., Eixarch, E., Forloni, G., Grandjean, J., Hekmatyar, K., Jacobs, R.E., Jelescu, I., Kurniawan, N.D., Lembo, G., Longo, D.L., Sta Maria, N.S., Micotti, E., Muñoz-Moreno, E., Ramos-Cabrer, P., Reichardt, W., Soria, G., Ielacqua, G.D. and Aswendt, M.
Imaging Neuroscience 2 : 1-23. 17 October 2024

SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Kalnytska, O., Qvist, P., Kunz, S., Conrad, T., Willnow, T.E. and Schmidt, V.
iScience 27 (1): 108725. 19 January 2024

MRT-basierte automatische Nierensegmentierung und daraus abgeleitete Marker: Eine Auswertung der bevölkerungsweiten NAKO Gesundheitsstudie.
Kellner, E., Sekula, P., Lipovsek, J., Russe, M., Horbach, H., Schlett, C.L., Nauck, M., Völzke, H., Kroencke, T., Bette, S., Kauczor, H.U., Keil, T., Pischon, T., Heid, I.M., Peters, A., Niendorf, T., Lieb, W., Bamberg, F., Büchert, M, Reichardt, W., Reisert, M. and Köttgen, A.
Deutsches Arzteblatt 121 : 284-290. 3 May 2024

Imaging markers derived from MRI-based automated kidney segmentation - an analysis of data from the German National Cohort (NAKO Gesundheitsstudie).
Kellner, E., Sekula, P., Lipovsek, J., Russe, M., Horbach, H., Schlett, C.L., Nauck, M., Völzke, H., Kröncke, T., Bette, S., Kauczor, H.U., Keil, T., Pischon, T., Heid, I.M., Peters, A., Niendorf, T., Lieb, W., Bamberg, F., Büchert, M., Reichardt, W., Reisert, M. and Köttgen, A.
Deutsches Arzteblatt International 121 (9): 284-290. 3 May 2024

Cytosolic nucleic acid sensors and interferon beta-1 activation drive radiation-induced anti-tumour immune effects in human pancreatic cancer cells.
Kerschbaum-Gruber, S., Kleinwächter, A., Popova, K., Kneringer, A., Appel, L.M., Stasny, K., Röhrer, A., Dias, A.B., Benedum, J., Walch, L., Postl, A., Barna, S., Kratzer, B., Pickl, W.F., Akalin, A., Horvat, F., Franke, V., Widder, J., Georg, D. and Slade, D.
Frontiers in Immunology 15 : 1286942. 20 September 2024

TF-FVIIa PAR2-β-arrestin in mouse signaling sustains organ dysfunction in coxsackievirus B3 infection.
Kespohl, M., Goetzke, C.C., Althof, N., Bredow, C., Kelm, N., Pinkert, S., Bukur, T., Bukur, V., Grunz, K., Kaur, D., Heuser, A., Mülleder, M., Sauter, M., Klingel, K., Weiler, H., Berndt, N., Gaida, M.M., Ruf, W. and Beling, A.
Arteriosclerosis Thrombosis and Vascular Biology 44 (4): 843-865. April 2024

TENM4 is an essential transduction component for touch and pain.
Khallaf, M.A., Huang, A.T.L., Dalmasso, L., Chakrabarti, S., Groeneveld, R., Sierra, Y.A.B., Garcia-Contreras, J.A., Schütz, A., Bégay, V., Hedtrich, S., Zhong, W., Popp, O., Mertins, P. and Lewin, G.R.
bioRxiv : 2024.10.10.617546. 12 October 2024

Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
Kiefer, M.F., Meng, Y., Yang, N., Vahrenbrink, M., Wulff, S., Li, C., Wowro, S.J., Petricek, K.M., Sommerfeld, M., Flores, R.E., Obermayer, B., Piepelow, K., Klaus, S., Hartl, K., Guillot, A., Tacke, F., Sigal, M. and Schupp, M.
American Journal of Physiology Endocrinology and Metabolism 327 (2): E203-E216. August 2024

Heat stress causes chromatin accessibility and related gene expression changes in crown tissues of barley (Hordeum vulgare).
Kiełbowicz-Matuk, A., Smaczniak, C., Mikołajczak, K., Kuczyńska, A., Xu, X., Braeuning, C. and Krajewski, P.
Plant Molecular Biology 114 (6): 115. 22 October 2024

The association of a healthy lifestyle index and imaging-based body fat distribution with glycemic status and Type 2 diabetes in the Multi Ethnic Cohort: a cross-sectional analysis.
Klapp, R., Nimptsch, K., Pischon, T., Wilkens, L.R., Lim, U., Guillermo, C., Setiawan, V.W., Shepherd, J.A, Le Marchand, L. and Maskarinec, G.
European Journal of Clinical Nutrition 78 (3): 236-242. March 2024

Dynamic parametric MRI and deep learning: unveiling renal pathophysiology through accurate kidney size quantification.
Klein, T., Gladytz, T., Millward, J.M., Cantow, K., Hummel, L., Seeliger, E., Waiczies, S., Lippert, C. and Niendorf, T.
NMR in Biomedicine 37 (4): e5075. April 2024

Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network.
Klinger, B., Rausch, I., Siebert, A., Kutz, H., Kruse, V., Kirchner, M., Mertins, P., Kieser, A., Blüthgen, N. and Kube, D.
PLoS Computational Biology 20 (10): e1012488. 1 October 2024

Bi-allelic PRRT2 variants may predispose to self-limited familial infantile epilepsy.
Koko, M., Elseed, M.A., Mohammed, I.N., Hamed, A.A., Abd Allah, A.S.I., Yahia, A., Siddig, R.A., Altmüller, J., Toliat, M.R., Elmahdi, E.O., Amin, M., Ahmed, E. A., Eltazi, I.Z.M., Elmugadam, F.A., Abdelgadir, W.A., Eltaraifee, E., Ibrahim, M.O.M., Ali, N.M.H., Malik, H.M., Babai, A.M., Bakhit, Y.H., Nürnberg, P., Ibrahim, M.E., Salih, M.A., Schubert, J., Elsayed, L.E.O. and Lerche, H.
European Journal of Human Genetics 32 (10): 1338-1342. October 2024

Protein intake and cancer: an umbrella review of systematic reviews for the evidence‑based guideline of the German Nutrition Society.
Kühn, T., Kalotai, N., Amini, A.M., Haardt, J., Lehmann, A., Schmidt, A., Buyken, A.E., Egert, S., Ellinger, S., Kroke, A., Lorkowski, S., Louis, S., Schulze, M.B., Schwingshackl, L., Siener, R., Stangl, G.I., Watzl, B., Zittermann, A. and Nimptsch, K.
European Journal of Nutrition 63 (5): 1471-1486. August 2024

An exploratory research report on brain mineralization in postoperative delirium and cognitive decline.
Lammers-Lietz, F., Borchers, F., Feinkohl, I., Hetzer, S., Kanar, C., Konietschke, F., Lachmann, G., Chien, C., Spies, C., Winterer, G., Zaborszky, L., Zacharias, N. and Paul, F.
European Journal of Neuroscience 59 (10): 2646-2664. May 2024

Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project.
Lange, B., Jaeger, V.K., Harries, M., Rücker, V., Streeck, H., Blaschke, S., Petersmann, A., Toepfner, N., Nauck, M., Hassenstein, M.J., Dreier, M., von Holt, I., Budde, A., Bartz, A., Ortmann, J., Kurosinski, M.A., Berner, R., Borsche, M., Brandhorst, G., Brinkmann, M., Budde, K., Deckena, M., Engels, G., Fenzlaff, M., Härtel, C., Hovardovska, O., Katalinic, A., Kehl, K., Kohls, M., Krüger, S., Lieb, W., Meyer-Schlinkmann, K.M., Pischon, T., Rosenkranz, D., Rübsamen, N., Rupp, J., Schäfer, C., Schattschneider, M., Schlegtendal, A., Schlinkert, S., Schmidbauer, L., Schulze-Wundling, K., Störk, S., Tiemann, C., Völzke, H., Winter, T., Klein, C., Liese, J., Brinkmann, F., Ottensmeyer, P.F., Reese, J.P., Heuschmann, P. and Karch, A.
Infection 52 (1): 139-153. February 2024

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M., Ratswohl, C., Garg, A., Schips, M., Vazquez Garcia, C., Spatt, L., Thibeault, C., Obermayer, B., Weiner, J., Moreno Velásquez, I., Gerhard, C., Stubbemann, P., Hanitsch, L.G., Pischon, T., Witzenrath, M., Sander, L.E., Kurth, F., Meyer-Hermann, M. and de la Rosa, K.
iScience 27 (3): 109330. 15 March 2024

Expansion and precise CRISPR-Cas9 gene repair of autologous T memory stem cells from patients with T cell immunodeficiencies.
Li, X., Chu, V.T., Kocks, C. and Rajewsky, K.
Bio-protocol 14 (20): e5085. 20 October 2024

Reliable off-resonance correction in high-field cardiac MRI using autonomous cardiac B0 segmentation with dual-modality deep neural networks.
Li, X., Huang, Y., Malagi, A., Yang, C.C., Yoosefian, G., Huang, L.T., Tang, E., Gao, C., Han, Fei, Bi, X., Ku, M.C., Yang, H.J. and Han, H.
Bioengineering 11 (3): 210. 23 February 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024

Effective inhibitor removal from wastewater samples increases sensitivity of RT-dPCR and sequencing analyses and enhances the stability of wastewater-based surveillance.
Linzner, N., Bartel, A., Schumacher, V., Grau, J.H., Wyler, E., Preuß, H., Garske, S., Bitzegeio, J., Kirst, E.B., Liere, K., Hoppe, S., Borodina, T.A., Altmüller, J., Landthaler, M., Meixner, M., Sagebiel, D. and Böckelmann, U.
Microorganisms 12 (12): 2475. December 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15 (1): 7027. 22 August 2024

Quantification of multi-compartment flow with spectral diffusion MRI.
Liu, M.M., Dyke, J., Gladytz, T., Jasse, J., Bolger, I., Calle, S., Pavaluri, S., Crews, T., Seshan, S., Salvatore, S., Stillman, I., Muthukuma, T., Taouli, B., Farouk, S., Lewis, S. and Bane, O.
arXiv : 2408.06427. 12 August 2024

Promising results of a clinical feasibility study: CIRBP as a potential biomarker in pediatric cardiac surgery.
Lücht, J., Seiler, R., Herre, A.L., Brankova, L., Fritsche-Guenther, R., Kirwan, J., Huscher, D., Münzfeld, H., Berger, F., Photiadis, J., Tong, G. and Schmitt, K.R.L.
Frontiers in Cardiovascular Medicine 11 : 1247472. 1 February 2024

Cerebral small vessel disease may not critically influence familial Parkinson’s disease.
Marhat, B., Bimala, M., Foddis, M., Holtgrewe, M., Beule, D., Bras, J., Guerreiro, R., Kola, V., Schmitt, H.M., Endres, M. and Sassi, C.
Research Square : rs.3.rs-4518069. 26 June 2024

Identifying cancer cells from calling single-nucleotide variants in scRNA-seq data.
Marot-Lassauzaie, V., Beneyto-Calabuig, S., Obermayer, B., Velten, L., Beule, D. and Haghverdi, L.
Bioinformatics 40 (9): btae512. September 2024

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease.
Menacho, C., Okawa, S., Alvarez-Merz, I., Wittich, A., Muñoz-Oreja, M., Lisowski, P., Pentimalli, T.M., Rybak-Wolf, A., Inak, G., Zakin, S., Thevandavakkam, M., Petersilie, L., Zaliani, A., Mlody, B., Seibt, A., Donnelly, J., Woleben, K., Fernandez-Checa, J., Herebian, D., Mayatepek, E., Rajewsky, N., Spinazzola, A., Schuelke, M., Perlstein, E., Rossi, A., Distelmaier, F., Holt, I.J., Pless, O., Rose, C., Del Sol, A. and Prigione, A.
bioRxiv : 2024.07.08.602501. 12 July 2024

Benchmarking whole exome sequencing in the German network for personalized medicine.
Menzel, M., Martis-Thiele, M., Goldschmid, H., Ott, A., Romanovsky, E., Siemanowski-Hrach, J., Seillier, L., Brüchle, N.O., Maurer, A., Lehmann, K.V., Begemann, M., Elbracht, M., Meyer, R., Dintner, S., Claus, R., Meier-Kolthoff, J.P, Blanc, E., Möbs, M., Joosten, M., Benary, M., Basitta, P., Hölscher, F., Tischler, V., Groß, T., Kutz, O., Prause, R., William, D., Horny, Kai, Goering, W., Sivalingam, S., Borkhardt, A., Blank, C., Junk, S.V., Yasin, L., Moskalev, E.A., Carta, M.G., Ferrazzi, F., Tögel, L., Wolter, S., Adam, E., Matysiak, U., Rosenthal, T., Dönitz, J., Lehmann, U., Schmidt, G., Bartels, S., Hofmann, W., Hirsch, S., Dikow, N., Göbel, K., Banan, R., Hamelmann, S., Fink, A., Ball, M., Neumann, O., Rehker, J., Kloth, M., Murtagh, J., Hartmann, N., Jurmeister, P., Mock, A., Kumbrink, J., Jung, A., Mayr, E.M., Jacob, A., Trautmann, M., Kirmse, S., Falkenberg, K., Ruckert, C., Hirsch, D., Immel, A., Dietmaier, W., Haack, T., Marienfeld, R., Fürstberger, A., Niewöhner, J., Gerstenmaier, U., Eberhardt, T., Greif, P.A., Appenzeller, S., Maurus, K., Doll, J., Jelting, Y., Jonigk, D., Märkl, B., Beule, D., Horst, D., Wulf, A.L., Aust, D., Werner, M., Reuter-Jessen, K., Ströbel, P., Auber, B., Sahm, F., Merkelbach-Bruse, S., Siebolts, U., Roth, W., Lassmann, S., Klauschen, F., Gaisa, N.T., Weichert, W., Evert, M., Armeanu-Ebinger, S., Ossowski, S., Schroeder, C., Schaaf, C.P., Malek, N., Schirmacher, P., Kazdal, D., Pfarr, N., Budczies, J. and Stenzinger, A.
European Journal of Cancer 211 : 114306. November 2024

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.
Mertens, T.F., Liebheit, A.T., Ehl, J., Köhler, R., Rakhymzhan, A., Woehler, A., Katthän, L., Ebel, G., Liublin, W., Kasapi, A., Triantafyllopoulou, A., Schulz, T.J., Niesner, R.A. and Hauser, A.E.
Nature Communications 15 (1): 1764. 26 February 2024

Likelihood of post-COVID condition in people with hybrid immunity; data from the German National Cohort (NAKO).
Mikolajczyk, R., Diexer, S., Klee, B., Pfrommer, L., Purschke, O., Fricke, J., Ahnert, P., Gabrysch, S., Gottschick, C., Bohn, B., Brenner, H., Buck, C., Castell, S., Gastell, S., Greiser, K.H., Harth, V., Heise, J.K., Holleczek, B., Kaaks, R., Keil, T., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, Cl., Michels, K.B., Moreno Velásquez, I., Obi, N., Panreck, L., Peters, A., Pischon, T., Schikowski, T., Schmidt, B., Standl, M., Stang, A., Völzke, H., Weber, A., Zeeb, H. and Karch, A.
Journal of Infection 89 (2): 106206. August 2024

Sodium as an important regulator of immunometabolism.
Miyauchi, H., Geisberger, S., Luft, F.C., Wilck, N., Stegbauer, J., Wiig, H., Dechend, R., Jantsch, J., Kleinewietfeld, M., Kempa, S. and Mueller, D.N.
Hypertension 81 (3): 426-435. March 2024

The association of pre-operative biomarkers of endothelial dysfunction with the risk of post-operative neurocognitive disorders: results from the BioCog study.
Moazzen, S., Janke, J., Slooter, A.J.C., Winterer, G., Spies, C., Pischon, T. and Feinkohl, I.
BMC Anesthesiology 24 (1): 358. 8 October 2024

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia.
Mochmann, L.H., Treue, D., Bockmayr, M., Silva, P., Zasada, C., Mastrobuoni, G., Bayram, S., Forbes, M., Jurmeister, P., Liebig, S., Blau, O., Schleich, K., Splettstoesser, B., Nordmann, T.M., von der Heide, E.K., Isaakidis, K., Schulze, V., Busch, C., Siddiq, H., Schlee, C., Hester, S., Fransecky, L., Neumann, M., Kempa, S., Klauschen, F. and Baldus, C.D.
Cancer Gene Therapy 31 (9): 1344-1356. September 2024

Do low levels of albuminuria predict mortality among young adults without major cardiovascular risk factors?
Moreno Velásquez, I. and Gigante, B.
European Journal of Preventive Cardiology 31 (17): 2056-2057. November 2024

RoCK and ROI: single-cell transcriptomics with multiplexed enrichment of selected transcripts and region-specific sequencing.
Moro, G., Mallona, I., Maillard, J., Brügger, M.D., Fazilaty, H., Szabo, Q., Valenta, T., Handler, K., Kerlin, F., Moor, A.E., Zinzen, R., Robinson, M.D., Brunner, E. and Basler, K.
bioRxiv : 2024.05.18.594120v2. 3 June 2024

A study protocol to characterise pathophysiological and molecular markers of rheumatic heart disease and degenerative aortic stenosis using multiparametric cardiovascular imaging and multiomics techniques.
Mutithu, D.W., Aremu, O.O., Mokaila, D., Bana, T., Familusi, M., Taylor, L., Martin, L.J., Heathfield, L.J., Kirwan, J.A., Wiesner, L., Adeola, H.A., Lumngwena, E.N., Manganyi, R., Skatulla, S., Naidoo, R. and Ntusi, N.A.B.
PLoS ONE 19 (5): e0303496. 13 May 2024

Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A., Popp, O., Kunz, S., Sporbert, A., Jung, S., Penning, L.C., Fendler, A., Mertins, P. and Birchmeier, W.
PLoS ONE 19 (3): e0282938. 21 March 2024

Structure, interaction and nervous connectivity of beta cell primary cilia.
Müller, A., Klena, N., Pang, S., Garcia, L.E.G., Topcheva, O., Aurrecoechea Duran, S., Sulaymankhil, D., Seliskar, M., Mziaut, H., Schöniger, E., Friedland, D., Kipke, N., Kretschmar, S., Münster, C., Weitz, J., Distler, M., Kurth, T., Schmidt, D., Hess, H.F., Xu, C.S., Pigino, G. and Solimena, M.
Nature Communications 15 (1): 9168. 24 October 2024

Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets.
Müller, A., Schmidt, D., Albrecht, J.P., Rieckert, L., Otto, M., Galicia Garcia, L.E., Fabig, G., Solimena, M. and Weigert, M.
Nature Protocols 19 (5): 1436-1466. May 2024

μCT imaging of a multi-organ vascular fingerprint in rats.
Napieczyńska, H., Kedziora, S.M., Haase, N., Müller, D.N., Heuser, A., Dechend, R. and Kraeker, K.
PLoS ONE 19 (10): e0308601. 14 October 2024

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiation.
Nguyen, L.T., Zimmermann, K., Kowenz-Leutz, E., Dörr, D., Schütz, A., Schönheit, J., Mildner, A. and Leutz, A.
iScience 27 (11): 111199. 15 November 2024

MRI of kidney size matters.
Niendorf, T., Gladytz, T., Cantow, K., Klein, T., Tasbihi, E., Velasquez Vides, J.R., Zhao, K., Millward, J.M., Waiczies, S. and Seeliger, E.
Magnetic Resonance Materials in Physics, Biology and Medicine 37 (4): 651-669. August 2024

Lebenserwartung.
Nimptsch, K. and Pischon, T.
In: Adipositas: Ätiologie, Folgekrankheiten, Diagnostik, Therapie. Springer, Berlin, Heidelberg, 351-358. ISBN 978-3-662-58894-9 27 July 2024

Epidemiology of obesity.
Nimptsch, K. and Pischon, T.
In: Handbook of eating disorders and obesity. Springer, Berlin, Heidelberg, Germany, 425-430. ISBN 978-3-662-67662-2 25 April 2024

Simulating rigid head motion artifacts on brain magnitude MRI data-Outcome on image quality and segmentation of the cerebral cortex.
Olsson, H., Millward, J.M., Starke, L., Gladytz, T., Klein, T., Fehr, J., Lai, W.C., Lippert, C., Niendorf, T. and Waiczies, S.
PLoS ONE 19 (4): e0301132. 16 April 2024

Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction.
Pain, O., Jones, A., Al Khleifat, A., Agarwal, D., Hramyka, D., Karoui, H., Kubica, J., Llewellyn, D.J., Ranson, J.M., Yao, Z., Iacoangeli, A. and Al-Chalabi, A.
Heliyon 10 (15): e35342. 15 August 2024

Mechanosensitive PIEZO2 channels shape coronary artery development.
Pampols-Perez, M., Fürst, C., Sánchez-Carranza, O., Cano, E., Raimundo, S., Lindberg, E.L., Taube, M., Heuser, A., Sporbert, A., Hübner, N., Gerhardt, H., Lewin, G.R. and Hammes, A.
bioRxiv : 2024.07.08.602502. 11 July 2024

Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture.
Patsalos, A., Halasz, L., Oleksak, D., Wei, X., Nagy, G., Tzerpos, P., Conrad, T., Hammers, D.W., Sweeney, H.L. and Nagy, L.
Journal of Clinical Investigation 134 (20): e173858. 15 October 2024

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I.V., Oelen, R., Groot, H.E., Benjamins, J.W., Brambs, S., Kaiser, R., Gottschlich, A., Hoffmann, G.V., Eivers, L., Martinez-Navarro, A., Bruns, N., Stiller, S., Akgöl, S., Yue, K., Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O., Kobold, S., Petzold, T., Zimmer, R., Enard, W., Saar, K., Mertins, P., Huebner, N., van der Harst, P., Franke, L.H., van der Wijst, M.G.P., Massberg, S., Heinig, M., Nicolai, L. and Stark, K.
Nature Medicine 30 (6): 1696-1710. June 2024

Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition study.
Pham, T.T., Nimptsch, K., Aleksandrova, K., Jenab, M., Fedirko, V., Wu, K., Eriksen, A.K., Tjønneland, A., Severi, G., Rothwell, J., Kaaks, R., Katzke, V., Catalano, A., Agnoli, C., Masala, G., De Magistris, M.S., Tumino, R., Vermeulen, R., Aizpurua, A., Trobajo-Sanmartín, C., Chirlaque, M.D., Sánchez, M.J., Lu, S.S.M., Cross, A.J., Christakoudi, S., Weiderpass, E. and Pischon, T.
International Journal of Cancer 154 (9): 1596-1606. 1 May 2024

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling.
Piletic, K., Kayvanjoo, A.H., Richter, F.C., Borsa, M., Lechuga-Vieco, A.V., Popp, O., Grenet, S., Ko, J.K.L., Zec, K., Kyriazi, M., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G. and Simon, A.K.
bioRxiv : 2024.09.17.613382. 17 September 2024

Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome.
Proce, R.O., Uddström, E., Steinecker, M., Wüsthoff, S., Teixeira Alves, L.G., Popp, O., Maxwell, K., Hortmann, L., Mertins, P., Landthaler, M., Bunina, D. and Hörnberg, H.
bioRxiv : 2024.12.18.628637. 20 December 2024

Delegation of the primary responsibility for MRI informed consent to technical assistants - findings from the NAKO health study.
Quinsten, A.S., Haubold, J., Kröncke, T., Friedrich, L., Pischon, T., Niendorf, T., Forsting, M., Hosten, N., Völzke, H., Bamberg, F., Schlett, C.L., Kauczor, H.U., Brandelik, S. and Theysohn, J.
Deutsches Ärzteblatt international 121 (7): 228-229. 5 April 2024

Helmet radio frequency phased array applicators enhance thermal magnetic resonance of brain tumors.
Rahimi, F., Nurzed, B., Eigentler, T.W., Berangi, M., Oberacker, E., Kuehne, A., Ghadjar, P., Millward, J.M., Schuhmann, R. and Niendorf, T.
Bioengineering 11 (7): 733. July 2024

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5 (8): 1267-1284. August 2024

Multilayer nanocarrier for the codelivery of interferons: a promising strategy for biocompatible and long-acting antiviral treatment.
Ramos, T.I., Villacis-Aguirre, C.A., Sandoval, F.S., Martin-Solano, S., Manrique-Suárez, V., Rodríguez, H., Santiago-Padilla, L., Debut, A., Gómez-Gaete, C., Arias, M.T., Montesino, R., Lamazares, E., Cabezas, I., Hugues, F., Parra, N.C., Altamirano, C., Ramos, O.S., Santiago-Vispo, N. and Toledo, J.R.
Pharmaceutics 16 (11): 1349. 22 October 2024

Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort.
Reichmann, R., Schulze, M.B., Pischon, T., Weikert, C. and Aleksandrova, K.
Age and Ageing 53 (Supplement_2): ii60-ii69. May 2024

Low income, being without employment, and living alone: how they are associated with cognitive functioning - results from the German national cohort (NAKO).
Rodriguez, F.S., Röhr, S., Dragano, N., Schmidt, B., Becher, H., Schikowski, T., Gastell, S., Harth, V., Hoven, H., Linseisen, J., Greiser, K.H., Leitzmann, M., Bohmann, P., Castell, S., Heise, J.K., Krist, L., Keil, T., Karch, A., Teismann, H., Moreno Velásquez, I., Pischon, T., Peters, A., Führer, A., Mikolajczyk, R., Günther, K., Brand, T., Meinke-Franze, C., Schipf, S., Grabe, H.J., Brenner, H., Koch-Gallenkamp, L., Berger, K., Wagner, M., Katzke, V., Lieb, W., Pabst, A. and Riedel-Heller, S.G.
Aging Neuropsychology and Cognition 17 December 2024 (In Press)

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance.
Rossi, A., Ruwolt, M., Kakouri, P., Kosten, T., Kunz, S., Puchkov, D., Reznick, J., Purfürst, B., Omerbašić, D., Méndez Aranda, D., Carai, G., Mastrobuoni, G., Hart, D.W., Carraro, M., Tommasin, L., Bennett, N.C., Bégay, V., Faelber, K., Daumke, O., Bernardi, P., Park, T.J., Kempa, S., Liu, F. and Lewin, G.R.
bioRxiv : 2024.09.30.615914. 2 October 2024

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15 (1): 3146. 11 April 2024

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts.
Ruiz-Orera, J., Miller, D.C., Greiner, J., Genehr, C., Grammatikaki, A., Blachut, S., Mbebi, J., Patone, G., Myronova, A., Adami, E., Dewani, N., Liang, N., Hummel, O., Mücke, M.B., Hildebrandt, T.B., Fritsch, G., Schrade, L., Zimmermann, W.H., Kondova, I., Diecke, S., van Heesch, S. and Hübner, N.
Nature Cardiovascular Research 3 (10): 1217-1235. October 2024

Comprehensive characterization of the viscoelastic properties of bovine submaxillary mucin (BSM) hydrogels and the effect of additives.
Rulff, H., Schmidt, R.F., Wei, L.F., Fentker, K., Kerkhoff, Y., Mertins, P., Mall, M.A., Lauster, D. and Gradzielski, M.
Biomacromolecules 25 (7): 4014-4029. 8 July 2024

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
Röwekamp, I., Maschirow, L., Rabes, A., Fiocca Vernengo, F., Hamann, L., Heinz, G.A., Mashreghi, M.F., Caesar, S., Milek, M., Fagundes Fonseca, A.C., Wienhold, S.M., Nouailles, G., Yao, L., Mousavi, S., Bruder, D., Boehme, J.D., Puzianowska-Kuznicka, M., Beule, D., Witzenrath, M., Löhning, M., Klose, C.S.N., Heimesaat, M.M., Diefenbach, A. and Opitz, B.
Proceedings of the National Academy of Sciences of the United States of America 121 (22): e2310864121. 28 May 2024

Targeted proteomics reveals quantitative differences in low-abundance glycosyltransferases of patients with congenital disorders of glycosylation.
Sakson, R., Beedgen, L., Bernhard, P., Alp, K.M., Lübbehusen, N., Röth, R., Niesler, B., Luzarowski, M., Shevchuk, O., Mayer, M.P., Thiel, C. and Ruppert, T.
International Journal of Molecular Sciences 25 (2): 1191. 18 January 2024

CompassDock: Comprehensive accurate assessment approach for deep learning-based molecular docking in inference and fine-tuning.
Sariguen, A., Franke, V., Uyar, B. and Akalin, A.
arXiv : 2406.06841. 1 October 2024

TTF-1 status in early-stage lung adenocarcinoma is an independent predictor of relapse and survival superior to tumor grading.
Schallenberg, S., Dernbach, G., Dragomir, M.P., Schlachtenberger, G., Boschung, K., Friedrich, C., Standvoss, K., Ruff, L., Anders, P., Grohé, C., Randerath, W., Merkelbach-Bruse, S., Quaas, A., Heldwein, M., Keilholz, U., Hekmat, J.K., Rückert, C., Büttner, R., Horst, D., Klauschen, F. and Frost, N.
European Journal of Cancer 197 : 113474. January 2024

The proteomic composition and organization of constitutive heterochromatin in mouse tissues.
Schmidt, A., Zhang, H., Schmitt, S., Rausch, C., Popp, O., Chen, J., Cmarko, D., Butter, F., Dittmar, G., Lermyte, F. and Cardoso, M.C.
Cells 13 (2): 139. 11 January 2024

Oncogene inactivation-induced senescence facilitates tumor relapse.
Schmitt, P., Hönig, K., Milojkovic, A., Anders, K., Schröck, E., Sauer, S., Uyar, B., Akalin, A., Martínez-Reyes, I. and Blankenstein, T.
bioRxiv : 2024.07.13.603369. 17 July 2024

A standardized nomenclature design for systematic referencing and identification of animal cellular material.
Schrade, L., Mah, N., Bandrowski, A., Chen, Y., Dewender, J., Diecke, S., Hiepen, C., Lancaster, M.A., Marques-Bonet, T., Martinez, S., Mueller, S.C., Navara, C., Prigione, A., Seltmann, S., Sochacki, J., Sutcliffe, M.A., Zywitza, V., Hildebrandt, T.B. and Kurtz, A.
Animals 14 (11): 1541. 1 June 2024

Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells.
Schöpf, F., Marongiu, G.L., Milaj, K., Sprink, T., Kikhney, J., Moter, A. and Roderer, D.
bioRxiv : 2024.02.28.582045. 1 March 2024

A mouse model of X-linked chronic granulomatous disease for the development of CRISPR/Cas9 gene therapy.
Sevim-Wunderlich, S., Dang, T., Rossius, J., Schnütgen, F. and Kuehn, R.
Genes 15 (6): 706. June 2024

lncRNA CDKN2B-AS1 regulates collagen expression.
Shi, W., Song, J., Weiner, J.M., Chopra, A., Dommisch, H., Beule, D. and Schaefer, A.S.
Human Genetics 143 (7): 907-919. July 2024

Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex.
Sokpor, Godwin, Ulmke, P.A., Nguyen, H.D., Pham, L., Kakani, P., Chu, V.T., Arnold, S.J., Brand-Saberi, B., Nguyen, H.P. and Tuoc, T.
bioRxiv : 2024.11.05.621758. 5 November 2024

Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O., Kirchner, M., Mertins, P., Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57 (9): 2140-2156.e10. 10 September 2024

Differences in anthropometric measures based on sex, age, and health status: findings from the German National Cohort (NAKO).
Stein, M.J., Fischer, B., Bohmann, P., Ahrens, W., Berger, K., Brenner, H., Günther, K., Harth, V., Heise, J.K., Karch, A., Klett-Tammen, C.J., Koch-Gallenkamp, L., Krist, L., Lieb, W., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Nimptsch, K., Obi, N., Peters, A., Pischon, T., Schipf, S., Schmidt, B., Stang, A., Thierry, S., Willich, S.N., Wirkner, K., Leitzmann, M.F. and Sedlmeier, A.M.
Deutsches Arzteblatt International 121 (7): 207-213. 5 April 2024

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Stöber, M.C., Chamorro González, R., Brückner, L., Conrad, T., Wittstruck, N., Szymansky, A., Eggert, A., Schulte, J.H., Koche, R.P., Henssen, A.G., Schwarz, R.F. and Haase, K.
Cell Reports 43 (9): 114711. 24 September 2024

Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection.
Sun, G., Kropp, K.A., Kirchner, M., Plückebaum, N., Selich, A., Serrero, M., Dhingra, A., Cabrera, J.R., Ritter, B., Bauerfeind, R., Wyler, E., Landthaler, M., Schambach, A., Sodeik, B., Mertins, P. and Viejo-Borbolla, A.
mBio 15 (2): e0330823. 14 February 2024

A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons.
Szabó, D., Franke, V., Bianco, S., Batiuk, M.Y., Paul, E.J., Kukalev, A., Pfisterer, U.G., Irastorza-Azcarate, I., Chiariello, A.M., Demharter, S., Zea-Redondo, L., Lopez-Atalaya, J.P., Nicodemi, M., Akalin, A., Khodosevich, K., Ungless, M.A., Winick-Ng, W. and Pombo, A.
bioRxiv : 2024.05.10.593308. 12 May 2024

DNA virus infections shape transposable elements activity in vitro and in vivo.
Tan, J., Franke, V., Neugebauer, E., Lagisquet, J., Kuderna, A.K., Walter, S., Landthaler, M., Ensser, A., Stamminger, T., Gramberg, T., Akalin, A., Wyler, E. and Full, F.
bioRxiv : 2024.04.18.589901. 19 April 2024

In vivo monitoring of renal tubule volume fraction using dynamic parametric MRI.
Tasbihi, E., Gladytz, T., Millward, J.M., Periquito, J.S., Starke, L., Waiczies, S., Cantow, K., Seeliger, E. and Niendorf, T.
Magnetic Resonance in Medicine 91 (6): 2532-2545. June 2024

Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.
Teixeira Alves, L.G., Baumgardt, M., Langner, C., Fischer, M., Maria Adler, J., Bushe, J., Firsching, T.C., Mastrobuoni, G., Grobe, J., Hoenzke, K., Kempa, S., Gruber, A.D., Hocke, A.C., Trimpert, J., Wyler, E. and Landthaler, M.
BMJ Open Respiratory Research 11 (1) 29 February 2024

Precision fMRI and cluster-failure in the individual brain.
Tellez Ceja, I.F., Gladytz, T., Starke, L., Tabelow, K., Niendorf, T. and Reimann, H.M.
Human Brain Mapping 45 (12): e26813. 15 August 2024

A systematic review of observational studies on the association between diet quality patterns and visceral adipose tissue.
Thimm, A., Maskarinec, G., Guillermo, C., Nimptsch, K. and Pischon, T.
British Journal of Nutrition 132 (11): 1530-1541. 14 December 2024

Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling.
Torres, M., Kirchner, M., Marks, C.G., Mertins, P. and Kramer, A.
Genes & Development 38 (21-24): 1020-1032. November 2024

Cellular landscape of adrenocortical carcinoma at single-nuclei resolution.
Tourigny, D.S., Altieri, B., Secener, A.K., Sbiera, S., Schauer, M.P., Arampatzi, P., Herterich, S., Sauer, S., Fassnacht, M. and Ronchi, C.L.
Molecular and Cellular Endocrinology 590 : 112272. 1 September 2024

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T., Graf, R., Acevedo-Ochoa, E., Trombke, J., Weber, T., Sommermann, T., Salomon, C., Kühn, R., Rajewsky, K. and Chu, V.T.
Leukemia 38 (9): 2003-2015. September 2024

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor.
Trepte, P., Secker, C., Olivet, J., Blavier, J., Kostova, S., Maseko, S.B., Minia, I., Silva Ramos, E., Cassonnet, P., Golusik, S., Zenkner, M., Beetz, S., Liebich, M.J., Scharek, N., Schütz, A., Sperling, M., Lisurek, M., Wang, Y., Spirohn, K., Hao, T., Calderwood, M.A., Hill, D.E., Landthaler, M., Choi, S.G., Twizere, J.C., Vidal, M. and Wanker, E.E.
Molecular Systems Biology 20 (4): 428-457. 2 April 2024

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue.
Trinks, A., Milek, M., Beule, D., Kluge, J., Florian, S., Sers, C., Horst, D., Morkel, M. and Bischoff, P.
Cellular Oncology 47 (4): 1221-1231. August 2024

Microglial sex differences in innate high anxiety and modulatory effects of minocycline.
Ugursu, B., Sah, A., Sartori, S., Popp, O., Mertins, P., Dunay, I.R., Kettenmann, H., Singewald, N. and Wolf, S.A.
Brain Behavior and Immunity 119 : 465-481. July 2024

Flexynesis: A deep learning framework for bulk multi-omics data integration for precision oncology and beyond.
Uyar, B., Savchyn, T., Wurmus, R., Sarigun, A., Shaik, M.M., Franke, V. and Akalin, A.
bioRxiv : 2024.07.16.603606. 18 July 2024

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation.
Vučićević, D., Hsu, C.W., Lopez Zepeda, L.S., Burkert, M., Hirsekorn, A., Bilić, I., Kastelić, N., Landthaler, M., Lacadie, S.A. and Ohler, U.
bioRxiv : 2024.09.12.612198. 12 September 2024

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho, A., Popp, O., Lenz, C., Pluska, L., Lambert, M., Dötsch, V., Mertins, P. and Sommer, T.
Life Science Alliance 7 (8): e202402740. August 2024

Generation and downstream analysis of single-cell and single-nuclei transcriptomes in brain organoids.
Wandres, M., Aigner, D., Kastelic, N., Boltengagen, A., Rybak-Wolf, A. and Rajewsky, N.
Journal of Visualized Experiments (205): e66225. 29 March 2024

Incidence of Parkinson’s disease in Germany based on prevalence data from 70 million patients of the statutory health insurance.
Wattenbach, C., Ellrichmann, G., Feinkohl, I., Voß, S. and Brinks, R.
BMC Neurology 24 (1): 221. 27 June 2024

Large‑scale assessment of physical activity in a population using high‑resolution hip‑worn accelerometry: the German National Cohort (NAKO).
Weber, A., van Hees, V.T., Stein, M.J., Gastell, S., Steindorf, K., Herbolsheimer, F., Ostrzinski, S., Pischon, T., Brandes, M., Krist, L., Marschollek, M., Greiser, K.H., Nimptsch, K., Brandes, B., Jochem, C., Sedlmeier, A.M., Berger, K., Brenner, H., Buck, C., Castell, S., Dörr, M., Emmel, C., Fischer, B., Flexeder, C., Harth, V., Hebestreit, A., Heise, J.K., Holleczek, B., Keil, T., Koch-Gallenkamp, L., Lieb, W., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Kluttig, A., Obi, N., Peters, A., Schmidt, B., Schipf, S., Schulze, M.B., Teismann, H., Waniek, S., Willich, S.N., Leitzmann, M.F. and Baurecht, H.
Scientific Reports 14 (1): 7927. 4 April 2024

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment.
Wei, T.T., Blanc, E., Peidli, S., Bischoff, P., Trinks, A., Horst, D., Sers, C., Blüthgen, N., Beule, D., Morkel, M. and Obermayer, B.
International Journal of Cancer 155 (9): 1655-1669. 1 November 2024

Combining Data Independent Acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification.
Welter, A.S., Gerwien, M., Kerridge, R., Alp, K.M., Mertins, P. and Selbach, M.
Molecular & Cellular Proteomics 23 (10): 100839. October 2024

IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia.
Werner, S., Okenve-Ramos, P., Hehlert, P., Zitouni, S., Priya, P., Mendonça, S., Sporbert, A., Spalthoff, C., Göpfert, M.C., Jana, S.C. and Bettencourt-Dias, M.
Life Science Alliance 7 (5): e202302289. May 2024

Health service use among migrants in the German National Cohort - the role of birth region and language skills.
Wiessner, C., Licaj, S., Klein, J., Bohn, B., Brand, T., Castell, S., Führer, A., Harth, V., Heier, M., Heise, J.K., Holleczek, B., Jaskulski, S., Jochem, C., Koch-Gallenkamp, L., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, C., Mikolajczyk, R., Moreno Velásquez, I., Obi, N., Pischon, T., Schipf, S., Thierry, S., Willich, S.N., Zeeb, H. and Becher, H.
International Journal of Public Health 69 : 1606377. 6 March 2024

Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E., Lauber, C., Manukyan, A., Deter, A., Quedenau, C., Teixeira Alves, L.G., Wylezich, C., Borodina, T., Seitz, S., Altmüller, J. and Landthaler, M.
Environment International 190 : 108875. August 2024

Interlaboratory comparison of standardised metabolomics and lipidomics analyses in human and rodent blood using the MxP® Quant 500 kit.
Zararsiz, G.E., Lintelmann, J., Cecil, A., Kirwan, J., Poschet, G., Gegner, H.M., Schuchardt, S., Guan, X.L., Saigusa, D., Wishart, D., Zheng, J., Mandal, R., Adams, K., Thompson, J.W., Snyder, M.P., Contrepois, K., Chen, S., Ashrafi, N., Akyol, S., Yilmaz, A., Graham, S.F., O'Connell, T.M., Kalecký, K., Bottiglieri, T., Limonciel, A., Pham, H.T., Koal, T., Adamski, J. and Kastenmüller, G.
bioRxiv : 2024.11.13.619447. 14 November 2024

Noninvasive assessment of diabetic kidney disease with MRI: hype or hope?
Zhao, K., Seeliger, E., Niendorf, T. and Liu, Z.
Journal of Magnetic Resonance Imaging 59 (5): 1494-1513. May 2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M., Pande, A., Margineanu, A., Lisewski, U., Purfürst, B., Zhu, H., Liang, L., Jia, S., Froehler, S., Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W., Raile, K., Sander, M. and Izsvák, Z.
iScience 27 (7): 110291. 19 July 2024

Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk.
de Biase, M.S., Massip, F., Wei, T.T., Giorgi, F.M., Stark, R., Stone, A., Gladwell, A., O'Reilly, M., Schütte, D., de Santiago, I., Meyer, K.B., Markowetz, F., Ponder, B.A.J., Rintoul, R.C. and Schwarz, R.F.
Genome Medicine 16 (1): 54. 8 April 2024

Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.
van Bentum, M., Klinger, B., Sieber, A., Lehmann, N., Haji, M., Naghiloo, S., Niquet, S., Mertins, P., Blüthgen, N. and Selbach, M.
bioRxiv : 2024.05.13.593849. 15 May 2024

Neuromuscular dysfunction in patient-derived FUS(R244RR)-ALS iPSC model via axonal downregulation of neuromuscular junction proteins.
von Kuegelgen, N., Ludwik, K., Mendonsa, S., Roemer, C., Becher, E., Breimann, L., Strauch, M., Mari, T., Mongellaz, S., Zuckerman, B., Grexa, N., Oliveras-Martinez, A., Woehler, A., Selbach, M., La Bella, V., Ulitsky, I. and Chekulaeva, M.
bioRxiv : 2024.08.17.607965. 17 August 2024

The (un)answered question: a data science powered music experiment.
von Kurnatowski, L., Wolff, B., Kernchen, S., Klapproth-Rieger, A., Heidrich, D., Haupt, C., Schreiber, A., Niendorf, T., Kosmider, A., Lobbes, M. and Hennecke, M.
Lecture Notes in Computer Science 14717 : 233-246. 2 June 2024

2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Aguirre, T., Hostachy, S., Dornan, G.L., Neuenschwander, M., Seyffarth, C., Haucke, V., Schütz, A., von Kries, J.P. and Fiedler, D.
eLife 21 : RP88982. 16 October 2023

The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans.
Ahmad, I., Lokau, J., Kespohl, B., Malik, N.A., Baig, S.M., Hartig, R., Behme, D., Schwab, R., Altmüller, J., Jameel, M., Mucha, S., Thiele, H., Tariq, M., Nürnberg, P., Erdmann, J. and Garbers, C.
Scientific Reports 13 (1): 13479. 18 August 2023

The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
Ahmed, S.M., Ragunathan, P., Shin, J., Peter, S., Kleissle, S., Neuenschwander, M., Schäfer, R., von Kries, J.P., Grüber, G. and Dröge, P.
FEBS Letters 597 (15): 1977-1988. August 2023

Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H.C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N. and Hilgers, V.
Cell 186 (11): 2438-2455. 25 May 2023

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel, L.M., Franke, V., Benedum, J., Grishkovskaya, I., Strobl, X., Polyansky, A., Ammann, G., Platzer, S., Neudolt, A., Wunder, A., Walch, L., Kaiser, S., Zagrovic, B., Djinovic-Carugo, K., Akalin, A. and Slade, D.
Nature Communications 14 (1): 166. 11 January 2023

Expanding the spectrum of EEF1D neurodevelopmental disorders: biallelic variants in the guanine exchange domain.
Averdunk, L., Al-Thihli, K., Surowy, H., Lüdecke, H.J., Drechsler, M., Yigit, G., Smorag, L., Hallak, B.A., Li, Y., Altmüller, J., Guthoff, T., Wallot, M., Nürnberg, P., Wollnik, B., Abou Jamra, R., Al-Maawali, A. and Wieczorek, D.
Clinical Genetics 103 (4): 484-491. April 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma.
Ballhausen, A., Ben Hamza, A., Welters, C., Dietze, K., Bullinger, L., Rahn, H.P., Hartmann, S., Hansmann, M.L. and Hansmann, L.
Cancer Immunology Immunotherapy 72 (2): 515-521. February 2023

Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14 (1): 6543. 17 October 2023

Renal MRI: from nephron to NMR signal.
Bane, O., Seeliger, E., Cox, E., Stabinska, J., Bechler, E., Lewis, S., Hickson, L.T.J., Francis, S., Sigmund, E. and Niendorf, T.
Journal of Magnetic Resonance Imaging 58 (6): 1660-1679. December 2023

Leveraging large language models for decision support in personalized oncology.
Benary, M., Wang, X.D., Schmidt, M., Soll, D., Hilfenhaus, G., Nassir, M., Sigler, C., Knödler, M., Keller, U., Beule, D., Keilholz, U., Leser, U. and Rieke, D.T.
JAMA Network Open 6 (11): e2343689. November 2023

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
Benedum, J., Franke, V., Appel, L.M., Walch, L., Bruno, M., Schneeweiss, R., Gruber, J., Oberndorfer, H., Frank, E., Strobl, X., Polyansky, A., Zagrovic, B., Akalin, A. and Slade, D.
Nature Communications 14 (1): 7912. 30 November 2023

MRI of implantation sites using parallel transmission of an optimized radiofrequency excitation vector.
Berangi, M., Kuehne, A., Waiczies, H. and Niendorf, T.
Tomography 9 (2): 603-620. 8 March 2023

The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing.
Bischoff, N., Wimberger, S., Kuehn, R., Laugesen, A., Turan, V., Larsen, B.D., Sørensen, C.S., Helin, K., Bennett, E.P., Maresca, M. and Brakebusch, C.
Gene and Genome Editing 5 : 100023. June 2023

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15 (1): 50. 20 July 2023

Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37 (11): 2237-2249. November 2023

Current practices in lc-ms untargeted metabolomics: a scoping review on the use of pooled quality control samples.
Broeckling, C.D., Beger, R.D., Cheng, L.L., Cumeras, R., Cuthbertson, D.J., Dasari, S., Davis, W.C., Dunn, W.B., Evans, A.M., Fernández-Ochoa, Á., Gika, H., Goodacre, R., Goodman, K.D., Gouveia, G.J., Hsu, P.C., Kirwan, J.A., Kodra, D., Kuligowski, J., Lan, R.S.L., Monge, M.E., Moussa, L.W., Nair, S.G., Reisdorph, N., Sherrod, S.D., Ulmer Holland, C., Vuckovic, D., Yu, L.R., Zhang, B., Theodoridis, G. and Mosley, J.D.
Analytical Chemistry 95 (51): 18645-18654. 26 December 2023

LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.
Bunatyan, L., Margineanu, A., Boutin, C., Montcouquiol, M., Bachmann, S., Christensen, E.I., Willnow, T.E. and Christ, A.
Cell and Tissue Research 392 (2): 535-551. May 2023

Monitoring kidney size to interpret MRI-based assessment of renal oxygenation in acute pathophysiological scenarios.
Cantow, K., Gladytz, T., Millward, J.M., Waiczies, S., Niendorf, T. and Seeliger, E.
Acta Physiologica 237 (2): e13868. February 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55 (5): 880-890. May 2023

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
Chatzinikolaou, G., Stratigi, K., Siametis, A., Goulielmaki, E., Akalestou-Clocher, A., Tsamardinos, I., Topalis, P., Austin, C., Bouwman, B.A.M., Crosetto, N., Altmüller, J. and Garinis, G.A.
Science Advances 9 (45): eadi2095. 10 November 2023

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
Chee, J.M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D.J., Bosch, F., Braun, R.E., Brown, S.D.M., Chin, H.J.G., Dickinson, M.E., Hsu, C.W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J.D., Herault, Y., de Angelis, M.H., Mammano, F., Nutter, L.M.J, Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J.K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K.C.K., Westerberg, H. and Moshiri, A.
BMC Biology 21 (1): 22. 3 February 2023

Association of the human gut microbiota with vascular stiffness.
Cuadrat, R.R.C., Goris, T., Birukov, A., Eichelmann, F., Andrade, B.G.N., Bang, C., Franke, A., Wittenbecher, C. and Schulze, M.B.
Scientific Reports 13 (1): 13348. 16 August 2023

Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation.
Cuadrat, R.R.C., Kratzer, A., Arnal, H.G., Rathgeber, A.C., Wreczycka, K., Blume, A., Gündüz, I.B., Ebenal, V., Mauno, T., Osberg, B., Moobed, M., Hartung, J., Jakobs, K., Seppelt, C., Meteva, D., Haghikia, A., Leistner, D.M., Landmesser, Ulf and Akalin, A.
NAR Genomics and Bioinformatics 5 (2): lqad061. June 2023

Bioactive phytochemicals from avocado oil processing by-products.
Cárdenas-Castro, A.P., Fernández-Ochoa, Á., Cádiz-Gurrea, M.d.l.L., Segura Carretero, A. and Sáyago-Ayerdi, S.G.
In: Bioactive phytochemicals from vegetable oil and oilseed processing by-products. Reference Series in Phytochemistry, 1 . Springer, Cham, Switzerland, 403-430. ISBN 978-3-030-91380-9 22 March 2023

Old discovery leading to new era: metabolic imaging of cancer with Deuterium MRI.
Ding, H., Haroon, A., Wan, S., Niendorf, T. and Adeleke, S.
Magnetochemistry 9 (1): 6. January 2023

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy.
Erger, F., Aryal, R.P., Reusch, B., Matsumoto, Y., Meyer, R., Zeng, J., Knopp, C., Noel, M., Muerner, L., Wenzel, A., Kohl, S., Tschernoster, N., Rappl, G., Rouvet, I., Schröder-Braunstein, J., Seibert, F.S., Thiele, H., Häusler, M.G., Weber, L.T., Büttner-Herold, M., Elbracht, M., Cummings, S.F., Altmüller, J., Habbig, S., Cummings, R.D. and Beck, B.B.
Proceedings of the National Academy of Sciences of the United States of America 120 (22): e2211087120. 30 May 2023

Radiofrequency induced heating of biodegradable orthopaedic screw implants during magnetic resonance imaging.
Espiritu, J., Berangi, M., Cwieka, H., Iskhakova, K., Kuehne, A., Florian Wieland, D.C., Zeller-Plumhoff, B., Niendorf, T., Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 25 : 86-94. 23 January 2023

Machine learning-based ozone and PM2.5 forecasting: application to multiple AQS sites in the Pacific Northwest.
Fan, K., Dhammapala, R., Harrington, K., Lamb, B. and Lee, Y.
Frontiers in Big Data 6 : 1124148. 24 February 2023

Metabolic syndrome and the risk of postoperative delirium and postoperative cognitive dysfunction: a multi-centre cohort study.
Feinkohl, I., Janke, J., Slooter, A.J.C., Winterer, G., Spies, C. and Pischon, T.
British Journal of Anaesthesia 131 (2): 338-347. August 2023

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma.
Finotto, L., Cole, B., Giese, W., Baumann, E., Claeys, A., Vanmechelen, M., Decraene, B., Derweduwe, M., Dubroja Lakic, N., Shankar, G., Nagathihalli Kantharaju, M., Albrecht, J.P., Geudens, I., Stanchi, F., Ligon, K.L., Boeckx, B., Lambrechts, D., Harrington, K., Van Den Bosch, L., De Vleeschouwer, S., De Smet, F. and Gerhardt, H.
EMBO Molecular Medicine 15 (11): e18144. 8 November 2023

Identification of radiomic biomarkers in a set of four skeletal muscle groups on Dixon MRI of the NAKO MR study.
Fischer, M., Küstner, T., Pappa, S., Niendorf, T., Pischon, T., Kröncke, T., Bette, S., Schramm, S., Schmidt, B., Haubold, J., Nensa, F., Nonnenmacher, T., Palm, V., Bamberg, F., Kiefer, L., Schick, F. and Yang, B.
BMC Medical Imaging 23 (1): 104. 8 August 2023

Potential contribution of ancient introgression to the evolution of a derived reproductive strategy in ricefishes.
Flury, J.M., Meusemann, K., Martin, S., Hilgers, L., Spanke, T., Böhne, A., Herder, F., Mokodongan, D., Altmüller, J., Wowor, D., Misof, B., Nolte, A.W. and Schwarzer, J.
Genome Biology and Evolution 15 (8): evad138. 29 August 2023

TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients.
Foddis, M., Blumenau, S., Holtgrewe, M., Paquette, K., Westra, K., Alonso, I., Macario, M.d.C., Morgadinho, A.S., Velon, A.G., Santo, G., Santana, I., Mönkäre, S., Kuuluvainen, L., Schleutker, J., Pöyhönen, M., Myllykangas, L., Pavlovic, A., Kostic, V., Dobricic, V., Lohmann, E., Hanagasi, H., Santos, M., Guven, G., Bilgic, B., Bras, J., Beule, D., Dirnagl, U., Guerreiro, R. and Sassi, C.
Neurobiology of Aging 123 : 208-215. March 2023

Advancements in pulsed stable isotope-resolved metabolomics.
Forbes, M., Geisberger, S., Pietzke, M., Mastrobuoni, G. and Kempa, S.
Handbook of Experimental Pharmacology 277 : 165-180. 3 March 2023

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N., Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A., André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M., Cui, C., Daumke, O., Del Bel, K.L., Eibel, H., Feng, X., Franke, V., Gebhardt, J.C.M., Götz, A., Grunwald, S., Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M., Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W., Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S., Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8 (79): eade7953. January 2023

Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP.
Franz, A., Weber, A.I., Preußner, M., Dimos, N., Stumpf, A., Ji, Y., Moreno-Velasquez, L., Voigt, A., Schulz, F., Neumann, A., Kuropka, B., Kuehn, R., Urlaub, H., Schmitz, D., Wahl, M.C. and Heyd, F.
Life Science Alliance 6 (3): e202201826. March 2023

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F., Thakkar, M., Hamann, W., Lopez Carballo, J., Jüttner, R., Voss, F.K., Becher, P.M., Westermann, D., Tschöpe, C., Heuser, A., Rocks, O., Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development.
Freitag, K., Eede, P., Ivanov, A., Sterczyk, N., Schneeberger, S., Borodina, T., Sauer, S., Beule, D. and Heppner, F.L.
Communications Biology 6 (1): 40. 13 January 2023

Cesium activates the neurotransmitter receptor for glycine.
Fricke, S., Harnau, M., Hetsch, F., Liu, H., Leonhard, J., Eylmann, A., Knauff, P., Sun, H., Semtner, M. and Meier, J.C.
Frontiers in Molecular Neuroscience 16 : 1018530. 22 May 2023

Fiber-orientation independent component of R(2)* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm.
Fritz, F.J., Mordhorst, L., Ashtarayeh, M., Periquito, J., Pohlmann, A., Morawski, M., Jaeger, C., Niendorf, T., Pine, K.J., Callaghan, M.F., Weiskopf, N. and Mohammadi, S.
Frontiers in Neuroscience 17 : 1133086. 25 August 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

Better together: data harmonization and cross-study analysis of abdominal MRI data from UK Biobank and the German National Cohort.
Gatidis, S., Kart, T., Fischer, M., Winzeck, S., Glocker, B., Bai, W., Bülow, R., Emmel, C., Friedrich, L., Kauczor, H.U., Keil, T., Kröncke, T., Mayer, P., Niendorf, T., Peters, A., Pischon, T., Schaarschmidt, B.M., Schmidt, B., Schulze, M.B., Umutle, L., Völzke, H., Küstner, T., Bamberg, F., Schölkopf, B. and Rueckert, D.
Investigative Radiology 58 (5): 346-354. 1 May 2023

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.
Geng, S., Paul, F., Kowalczyk, I., Raimundo, S., Sporbert, A., Mamo, T.M. and Hammes, A.
Frontiers in Cell and Developmental Biology 11 : 1173688. 7 April 2023

"suMus," a novel digital system for arm movement metrics and muscle energy expenditure.
Gerhalter, Teresa, Müller, Christina, Maron, Elke, Thielen, Markus, Schätzl, Teresa, Mähler, A., Schütte, T., Boschmann, M., Herzer, René, Spuler, S. and Gazzerro, E.
Frontiers in Physiology 14 : 1057592. 26 January 2023

A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D.A., Blockx, I., Bortel, A., Broadwater, M., Cardoso, B.M., Célestine, M., Chavez-Negrete, J.E., Choi, S., Christiaen, E., Clavijo, P., Colon-Perez, L., Cramer, S., Daniele, T., Dempsey, E., Diao, Y., Doelemeyer, A., Dopfel, D., Dvořáková, L., Falfán-Melgoza, C., Fernandes, F.F., Fowler, C.F., Fuentes-Ibañez, A., Garin, C.M., Gelderman, E., Golden, C.E.M., Guo, C.C G., Henckens, M.J.A.G., Hennessy, L.A., Herman, P., Hofwijks, N., Horien, C., Ionescu, T.M., Jones, J., Kaesser, J., Kim, E., Lambers, H., Lazari, A., Lee, S.H., Lillywhite, A., Liu, Y., Liu, Y.Y., López-Castro, A., López-Gil, X., Ma, Z., MacNicol, E., Madularu, D., Mandino, F., Marciano, S., McAuslan, M.J., McCunn, P., McIntosh, A., Meng, X., Meyer-Baese, L., Missault, S., Moro, F., Naessens, D.M.P., Nava-Gomez, L.J., Nonaka, H., Ortiz, J.J., Paasonen, J., Peeters, L.M., Pereira, M., Perez, P.D., Pompilus, M., Prior, M., Rakhmatullin, R., Reimann, H.M., Reinwald, J., Del Rio, R.T., Rivera-Olvera, A., Ruiz-Pérez, D., Russo, G., Rutten, T.J., Ryoke, R., Sack, M., Salvan, P., Sanganahalli, B.G., Schroeter, A., Seewoo, B.J., Selingue, E., Seuwen, A., Shi, B., Sirmpilatze, N., Smith, J.A.B., Smith, C., Sobczak, F., Stenroos, P.J., Straathof, M., Strobelt, S., Sumiyoshi, A., Takahashi, K., Torres-García, M.E, Tudela, R., van den Berg, M., van der Marel, K., van Hout, A.T.B., Vertullo, R., Vidal, B., Vrooman, R.M., Wang, V.X., Wank, I., Watson, D.J.G., Yin, T., Zhang, Y., Zurbruegg, S., Achard, S., Alcauter, S., Auer, D.P., Barbier, E.L., Baudewig, J., Beckmann, C.F., Beckmann, N., Becq, G.J.P.C., Blezer, E.L.A., Bolbos, R., Boretius, S., Bouvard, S., Budinger, E., Buxbaum, J.D., Cash, D., Chapman, V., Chuang, K.H., Ciobanu, L., Coolen, B.F., Dalley, J.W., Dhenain, M., Dijkhuizen, R.M., Esteban, O., Faber, C., Febo, M., Feindel, K.W., Forloni, G., Fouquet, J., Garza-Villarreal, E.A., Gass, N., Glennon, J.C., Gozzi, A., Gröhn, O., Harkin, A., Heerschap, A., Helluy, X., Herfert, K., Heuser, A., Homberg, J.R., Houwing, D.J., Hyder, F., Ielacqua, G.D., Jelescu, I.O., Johansen-Berg, H., Kaneko, G., Kawashima, R., Keilholz, S.D., Keliris, G.A., Kelly, C., Kerskens, C., Khokhar, J.Y., Kind, P.C., Langlois, J.B., Lerch, J.P., López-Hidalgo, M.A, Manahan-Vaughan, D., Marchand, F., Mars, R.B., Marsella, G., Micotti, E., Muñoz-Moreno, E., Near, J., Niendorf, T., Otte, W.M., Pais-Roldán, P., Pan, W.J., Prado-Alcalá, R.A., Quirarte, G.L., Rodger, J., Rosenow, T., Sampaio-Baptista, C., Sartorius, A., Sawiak, S.J., Scheenen, T.W.J., Shemesh, N., Shih, Y.Y.I., Shmuel, A., Soria, G., Stoop, R., Thompson, G.J., Till, S.M., Todd, N., Van Der Linden, A., van der Toorn, A., van Tilborg, G.A.F, Vanhove, C., Veltien, A., Verhoye, M., Wachsmuth, L., Weber-Fahr, W., Wenk, P., Yu, X., Zerbi, V., Zhang, N., Zhang, B.B., Zimmer, L., Devenyi, G.A., Chakravarty, M.M. and Hess, A.
Nature Neuroscience 26 (4): 673-681. April 2023

Sex-specific microglia state in the neuroligin-4 knock-out mouse model of autism spectrum disorder.
Guneykaya, D., Ugursu, B., Logiacco, F., Popp, O., Feiks, M.A., Meyer, N., Wendt, S., Semtner, M., Cherif, F., Gauthier, C., Madore, C., Yin, Z., Çınar, Ö., Arslan, T., Gerevich, Z., Mertins, P., Butovsky, O., Kettenmann, H. and Wolf, S.A.
Brain Behavior and Immunity 111 : 61-75. July 2023

NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling.
Hanssen, F., Gabernet, G., Smith, N.H., Mertes, C., Neogi, A.G., Brandhoff, L., Ossowski, A., Altmueller, J., Becker, K., Petzold, A., Sturm, M., Stöcker, T., Sivalingam, S., Brand, F., Schmidt, A., Buness, A., Probst, A.J., Motameny, S. and Köster, J.
F1000Research 12 : 1125. 11 September 2023

Seropositivity of Borrelia burgdorferi s.l. in Germany-an analysis across four German National Cohort (NAKO) study sites.
Hassenstein, M.J., Pischon, T., Karch, A., Peters, A., Kerrinnes, T., Teismann, H., Schneider, A., Thierry, S., Moreno Velásquez, I., Janke, J., Kemmling, Y. and Castell, S.
Scientific Reports 13 (1): 21087. 30 November 2023

Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
Haueise, T., Schick, F., Stefan, N., Schlett, C.L., Weiss, J.B., Nattenmüller, J., Göbel-Guéniot, K., Norajitra, T., Nonnenmacher, T., Kauczor, H.U., Maier-Hein, K.H., Niendorf, T., Pischon, T., Jöckel, K.H., Umutlu, L., Peters, A., Rospleszcz, S., Kröncke, T., Hosten, N., Völzke, H., Krist, L., Willich, S.N., Bamberg, F. and Machann, J.
Science Advances 9 (19): eadd0433. 12 May 2023

Generation of two mother-child pairs of iPSCs from maternally inherited Leigh syndrome patients with m.8993 T > G and m.9176 T > G MT-ATP6 mutations.
Henke, M.T., Zink, A., Diecke, S., Prigione, A. and Schuelke, M.
Stem Cell Research 67 : 103030. March 2023

Accelerated simultaneous T2 and T2* mapping of multiple sclerosis lesions using compressed sensing reconstruction of radial RARE-EPI MRI.
Herrmann, C.J.J., Starke, L., Millward, J.M., Kuchling, J., Paul, F. and Niendorf, T.
Tomography 9 (1): 299-314. 31 January 2023

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Heynen, G.J.J.E., Baumgartner, F., Heider, M., Patra, U., Holz, M., Braune, J., Kaiser, M., Schäffer, I., Bamopoulos, S.A., Ramberger, E., Murgai, A., Ng, Y.L.D., Demel, U.M., Laue, D., Liebig, S., Krüger, J., Janz, M., Nogai, A., Schick, M., Mertins, P., Müller, S., Bassermann, F., Krönke, J., Keller, U. and Wirth, M.
Blood Advances 7 (4): 469-481. 28 February 2023

In vitro fertilization program in white rhinoceros.
Hildebrandt, T.B., Holtze, S., Colleoni, S., Hermes, R., Stejskal, J., Lekolool, I., Ndereeh, D., Omondi, P., Kariuki, L., Mijele, D., Mutisya, S., Ngulu, S., Diecke, S., Hayashi, K., Lazzari, G., de Mori, B., Biasetti, P., Quaggio, A., Galli, C. and Goeritz, F.
Reproduction 166 (6): 383-399. 25 October 2023

A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish.
Huljev, K., Shamipour, S., Pinheiro, D., Preusser, F., Steccari, I., Sommer, C.M., Naik, S. and Heisenberg, C.P.
Developmental Cell 58 (7): 582-596.e7. 10 April 2023

Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 11 (3): e006784. 14 March 2023

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Jiang, Q., Stachelscheid, J., Bloehdorn, J., Pacholewska, A., Aszyk, C.M., Grotenhuijs, F., Müller, T.A., Onder, O., Wagle, P., Herling, C.D., Kleppe, M., Wang, Z., Coombes, K.R., Robrecht, S., Dalvi, P.S., Plosnita, B., Mayer, P., Abruzzo, L.V., Altmüller, J., Gathof, B.S., Persigehl, T., Fischer, K., Jebaraj, B.M.C., Rienhoff, H.Y., Ecker, R.C., Zhao, Y., Bruns, C.J., Stilgenbauer, S., Elenitoba-Johnson, K.S.J., Hallek, M., Schweiger, M.R., Odenthal, M., Vasyutina, E. and Herling, M.
Blood 142 (1): 44-61. 6 July 2023

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Jordan, P., Costa, A., Specker, E., Popp, O., Volkamer, A., Piske, R., Obrusnik, T., Kleissle, S., Stuke, K., Rex, A., Neuenschwander, M., von Kries, J.P., Nazare, M., Mertins, P., Kettenmann, H. and Wolf, S.A.
PLoS ONE 18 (2): e0278325. 6 February 2023

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
Keil, P., Wulf, A., Kachariya, N., Reuscher, S., Hühn, K., Silbern, I., Altmüller, J., Keller, M., Stehle, R., Zarnack, K., Sattler, M., Urlaub, H. and Sträßer, K.
Nucleic Acids Research 51 (2): 831-851. 25 January 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24 (3): 414-422. March 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Translating metabolomics into clinical practice.
Kirwan, J.A.
Nature Reviews Bioengineering 1 : 228-229. April 2023

Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria.
Kourpa, A., Schulz, A., Mangelsen, E., Kaiser-Graf, D., Koppers, N., Stoll, M., Rothe, M., Bader, M., Purfürst, B., Kunz, S., Gladytz, T., Niendorf, T., Bachmann, S., Mutig, K., Bolbrinker, J., Panakova, D. and Kreutz, R.
Hypertension 80 (4): 771-782. April 2023

Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia.
Kuhrt, L.D., Motta, E., Elmadany, N., Weidling, H., Fritsche-Guenther, R., Efe, I.E., Cobb, O., Chatterjee, J., Boggs, L.G., Schnauß, M., Diecke, S., Semtner, M., Anastasaki, C., Gutmann, D.H. and Kettenmann, H.
Disease Models & Mechanisms 16 (12): dmm049861. December 2023

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119 (18): 2902-2916. December 2023

Germany's journey toward 14 Tesla human magnetic resonance.
Ladd, M.E., Quick, H.H., Speck, O., Bock, M., Doerfler, A., Forsting, M., Hennig, J., Ittermann, B., Möller, H.E., Nagel, A.M., Niendorf, T., Remy, S., Schaeffter, T., Scheffler, K., Schlemmer, H.P., Schmitter, S., Schreiber, L., Shah, N.J., Stöcker, T., Uder, M., Villringer, A., Weiskopf, N., Zaiss, M. and Zaitsev, M.
Magnetic Resonance Materials in Physics Biology and Medicine 36 (2): 191-210. April 2023

Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini, I., Emmenegger, L., Zappulo, A., Rybak-Wolf, A., Wurmus, R., Oliveras Martinez, A., Cerda Jara, C., Boltengagen, A., Hessler, T., Mastrobuoni, G., Kempa, S., Zinzen, R., Woehler, A. and Rajewsky, N.
Nature Methods 20 (10): 1544-1552. October 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14 (1): 3025. 25 May 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T., Belabed, H., Kücükdisli, M., Metag, J., Roske, Y., Prokofeva, P., Ohashi, Y., Horatscheck, A., Cirillo, D., Krauss, M., Schmied, C., Neuenschwander, M., von Kries, J.P., Médard, G., Kuster, Be., Perisic, O., Williams, R.L., Daumke, O., Payrastre, B., Severin, S., Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic.
Logiacco, F., Grzegorzek, L.C., Cordell, E.C., Popp, O., Mertins, P., Gutmann, D.H., Kettenmann, H. and Semtner, M.
Acta Neuropathologica Communications 11 (1): 36. 9 March 2023

Serum starvation accelerates intracellular metabolism in endothelial cells.
Lorenz, M., Fritsche-Guenther, R., Bartsch, C., Vietzke, A., Eisenberger, A., Stangl, K., Stangl, V. and Kirwan, J.A.
International Journal of Molecular Sciences 24 (2): 1189. 7 January 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out.
Ludwik, K.A., Opitz, R., Jyrch, S., Megges, M., Weiner, J., Beule, D., Kühnen, P. and Stachelscheid, H.
Stem Cell Research 73 : 103256. 21 November 2023

ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs.
Ludwik, K.A., Telugu, N., Schommer, S., Stachelscheid, H. and Diecke, S.
STAR Protocols 4 (3): 102406. 15 September 2023

Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblasts.
Lyssy, F., Guettler, J., Brugger, B.A., Stern, C., Forstner, D., Nonn, O., Fischer, C., Herse, F., Wernitznig, S., Hirschmugl, B., Wadsack, C. and Gauster, M.
Reproductive BioMedicine Online 47 (2): 103215. August 2023

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J., Costanzo, M., Sanaki-Matsumiya, M., Girardot, C., Hayashi, M., Hayashi, K., Diecke, S., Hildebrandt, T.B., Lazzari, G., Wu, J., Petkov, S., Behr, R., Trivedi, V., Matsuda, M. and Ebisuya, M.
Cell Stem Cell 30 (7): 938-949.e7. 6 July 2023

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera, J.A., Leu, C., Macnee, M., Khoury, J., Hoffmann, L., Coras, R., Kobow, K., Bhattarai, N., Pérez-Palma, E., Hamer, H., Brandner, S., Rössler, K., Bien, C.G., Kalbhenn, T., Pieper, T., Hartlieb, T., Butler, E., Genovese, G., Becker, K., Altmüller, J., Niestroj, L.M., Ferguson, L., Busch, R.M., Nürnberg, P., Najm, I., Blümcke, I. and Lal, D.
Brain 146 (4): 1342-1356. April 2023

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration.
Löffler, J., Noom, A., Ellinghaus, A., Dienelt, A., Kempa, S. and Duda, G.N.
Communications Biology 6 (1): 327. 27 March 2023

Generation of an NCS1 gene knockout human induced pluripotent stem cell line using CRISPR/Cas9.
Maierhof, S.K., Schinke, C., Cernoch, J., Hew, L., Bruske, L.P., Fernandez Vallone, V., Fischer, K., Stachelscheid, H., Huehnchen, P., Endres, M., Diecke, S., Telugu, N.S. and Boehmerle, W.
Stem Cell Research 73 : 103253. December 2023

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity.
Mangiante, L., Alcala, N., Sexton-Oates, A., Di Genova, A., Gonzalez-Perez, A., Khandekar, A., Bergstrom, E.N., Kim, J., Liu, X., Blazquez-Encinas, R., Giacobi, C., Le Stang, N., Boyault, S., Cuenin, C., Tabone-Eglinger, S., Damiola, F., Voegele, C., Ardin, M., Michallet, M.C., Soudade, L., Delhomme, T.M., Poret, A., Brevet, M., Copin, M.C., Giusiano-Courcambeck, S., Damotte, D., Girard, C., Hofman, V., Hofman, P., Mouroux, J., Cohen, C., Lacomme, S., Mazieres, J., de Montpreville, V.T., Perrin, C., Planchard, G., Rousseau, N., Rouquette, I., Sagan, C., Scherpereel, A., Thivolet, F., Vignaud, J.M., Jean, D., Ilg, A.G.S., Olaso, R., Meyer, V., Boland-Auge, A., Deleuze, J.F., Altmuller, J., Nuernberg, P., Ibáñez-Costa, A., Castaño, J.P., Lantuejoul, S., Ghantous, A., Maussion, C., Courtiol, P., Hernandez-Vargas, H., Caux, C., Girard, N., Lopez-Bigas, N., Alexandrov, L.B., Galateau-Salle, F., Foll, M. and Fernandez-Cuesta, L.
Nature Genetics 55 (4): 607-618. April 2023

Replicative aging impedes stress-induced assembly of a key human protein disaggregase.
Mathangasinghe, Y., Alberts, N., Rosado, C.J., Cox, D., Payne, N.L., Ormsby, A.R., Alp, K.M., Sakson, R., Uthishtran, S., Ruppert, T., Arumugam, S., Hatters, D.M., Kampinga, H.H. and Nillegoda, N.B.
bioRxiv : 2022.06.25.497591. 8 January 2023

Bioactive phytochemicals from sesame oil processing by-products.
Mekky, R.H., Hegazy, M.M., Cádiz-Gurrea, M.d.l.L., Fernández-Ochoa, Á. and Segura Carretero, A.
In: Bioactive phytochemicals from vegetable oil and oilseed processing by-products. Reference Series in Phytochemistry, 1 . Springer, Cham, Switzerland, 155-194. ISBN 978-3-030-91380-9 22 March 2023

Probing renal oxygenation with T2*-sensitized MRI (BOLD-MRI).
Mendichovszky, I.A., Milani, B., Li, L.P., Niendorf, T., Pruijm, M. and Prasad, P.V.
In: Advanced clinical MRI of the kidney : methods and protocols. Springer, Cham, 133-151. ISBN 978-3-031-40168-8 18 November 2023

Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S., von Kügelgen, N., Dantsuji, S., Ron, M., Breimann, L., Baranovskii, A., Lödige, I., Kirchner, M., Fischer, M., Zerna, N., Bujanic, L., Mertins, P., Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26 (3): 394-405. March 2023

Human induced pluripotent stem cell-derived pericytes as scalable and editable source to study direct lineage reprogramming into induced neurons.
Menon, R., Petrucci, L., Lohrer, B., Zhang, J., Schulze, M., Schichor, C., Winner, B., Winkler, J., Riemenschneider, M.J., Kühn, R., Falk, S. and Karow, M.
Cellular Reprogramming 25 (5): 212-223. 13 October 2023

Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.
Mhlekude, B., Postmus, D., Stenzel, S., Weiner, J., Jansen, J., Zapatero-Belinchón, F.J., Olmer, R., Richter, A., Heinze, J., Heinemann, N., Mühlemann, B., Schroeder, S., Jones, T.C., Müller, M.A., Drosten, C., Pich, A., Thiel, V., Martin, U., Niemeyer, D., Gerold, G., Beule, D. and Goffinet, C.
PLoS Pathogens 19 (9): e1011657. 25 September 2023

Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C., Lisowski, P., Genehr, C., Wanker, E.E., Priller, J., Prigione, A. and Diecke, S.
Stem Cell Research 68 : 103056. April 2023

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A.L., Tchenio, A., Benson, S., Vendrell, M., D'Alessandro, A., Beule, D., Pellerin, L., Mameli, M. and Paolicelli, R.C.
Nature Communications 14 (1): 5749. 16 September 2023

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes, R., Pascual-Reguant, A., Koehler, R., Liebeskind, J., Liebheit, A., Bauherr, S., Philipsen, L., Dittmayer, C., Laue, M., von Manitius, R., Elezkurtaj, S., Durek, P., Heinrich, F., Heinz, G.A., Guerra, G.M., Obermayer, B., Meinhardt, J., Ihlow, J., Radke, J., Heppner, F.L., Enghard, P., Stockmann, H., Aschman, T., Schneider, J., Corman, V.M., Sander, L.E., Mashreghi, M.F., Conrad, T., Hocke, A.C., Niesner, R.A., Radbruch, H. and Hauser, A.E.
Nature Communications 14 (1): 791. 11 February 2023

Bringing MRI to low- and middle-income countries: Directions, challenges and potential solutions.
Murali, S., Ding, H., Adedeji, F., Qin, C., Obungoloch, J., Asllani, I., Anazodo, U., Ntusi, N.A.B., Mammen, R., Niendorf, T. and Adeleke, S.
NMR in Biomedicine 37 (7): e4992. July 2023

High-throughput metabolomics applications in pathogenesis and diagnosis of valvular heart disease.
Mutithu, D.W., Kirwan, J.A., Adeola, H.A., Aremu, O.O., Lumngwena, E.N., Wiesner, L., Skatulla, S., Naidoo, R. and Ntusi, N.A.B.
Reviews in Cardiovascular Medicine 24 (6): 169. June 2023

The Berlin-Buch respiration chamber for energy expenditure measurements.
Mähler, A., Schütte, T., Steiniger, J. and Boschmann, M.
European Journal of Applied Physiology 123 (6): 1359-1368. June 2023

Instrumental drift in untargeted metabolomics: optimizing data quality with intrastudy QC samples.
Märtens, A., Holle, J., Mollenhauer, B., Wegner, A., Kirwan, J. and Hiller, K.
Metabolites 13 (5): 665. 16 May 2023

Salt sensitivity includes effects on immune cell signalling and metabolism.
Müller, D.N., Geisberger, S., Kleinewietfeld, M. and Jantsch, J.
Nature Reviews Immunology 23 (6): 341-342. June 2023

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Neuschulz, A., Bakina, O., Badillo Lisakowski, V., Olivares-Chauvet, P., Conrad, T., Gotthardt, M., Kettenmann, H. and Junker, J.P.
Molecular Systems Biology 19 (2): e11147. 10 February 2023

SODAR: managing multiomics study data and metadata.
Nieminen, M., Stolpe, O., Kuhring, M., Weiner, J., Pett, P., Beule, D. and Holtgrewe, M.
GigaScience 12 : giad052. 27 July 2023

Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
Nikopoulou, C., Kleinenkuhnen, N., Parekh, S., Sandoval, T., Ziegenhain, C., Schneider, F., Giavalisco, P., Donahue, K.F., Vesting, A.J., Kirchner, M., Bozukova, M., Vossen, C., Altmüller, J., Wunderlich, T., Sandberg, R., Kondylis, V., Tresch, A. and Tessarz, P.
Nature Aging 3 (11): 1430-1445. November 2023

Disease- and sex-specific differences in patients with heart valve disease: a proteome study.
Nordmeyer, S., Kraus, M., Ziehm, M., Kirchner, M., Schafstedde, M., Kelm, M., Niquet, S., Stephen, M.M., Baczko, I., Knosalla, C., Schapranow, M.P., Dittmar, G., Gotthardt, M., Falcke, M., Regitz-Zagrosek, V., Kuehne, T. and Mertins, P.
Life Science Alliance 6 (3): e202201411. March 2023

Radiofrequency antenna concepts for human cardiac MR at 14.0 T.
Nurzed, B., Kuehne, A., Aigner, C.S., Schmitter, S., Niendorf, T. and Eigentler, T.W.
Magnetic Resonance Materials in Physics Biology and Medicine 36 (2): 257-277. April 2023

Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation.
Obermayer, B., Keilholz, L., Conrad, T., Frentsch, M., Blau, I.W., Vuong, L., Lesch, S., Movasshagi, K., Tietze-Stolley, C., Loyal, L., Henze, L., Penack, O., Stervbo, U., Babel, N., Haas, S., Beule, D., Bullinger, L., Wittenbecher, F. and Na, I.K.
Frontiers in Immunology 14 : 1114368. 10 February 2023

Modeling of ACTN4-based podocytopathy using Drosophila nephrocytes.
Odenthal, J., Dittrich, S., Ludwig, V., Merz, T., Reitmeier, K., Reusch, B., Höhne, M., Cosgun, Z.C., Hohenadel, M., Putnik, J., Göbel, H., Rinschen, M.M., Altmüller, J., Koehler, S., Schermer, B., Benzing, T., Beck, B.B., Brinkkötter, P.T., Habbig, S. and Bartram, M.P.
Kidney International Reports 8 (2): 317-329. February 2023