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Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI

Item Type:Article
Title:Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI
Creators Name:Utting, J.F., Kozerke, S., Schnitker, R. and Niendorf, T.
Abstract:PURPOSE: To compare k-t BLAST (broad-use linear-acquisition speedup technique)/k-t SENSE (sensitivity encoding) with conventional SENSE applied to a simple fMRI paradigm. MATERIALS AND METHODS: Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was performed at 3 T using a displaced ultra-fast low-angle refocused echo (UFLARE) pulse sequence with a visual stimulus in a block paradigm. Conventional SENSE and k-t BLAST/k-t SENSE data were acquired. Also, k-t BLAST/k-t SENSE was simulated at different undersampling factors from fully sampled data after removal of lines of k-space data. Analysis was performed using SPM5. RESULTS: Sensitivity to the BOLD response in k-t BLAST/k-t SENSE was comparable with that of SENSE in images acquired at an undersampling factor of 2.3. Simulated k-t BLAST/k-t SENSE yielded reliable detection of activation-induced BOLD contrast at undersampling factors of 5 or less. Sensitivity increased significantly when training data were included in k-space before Fourier transformation (known as "plug-in"). CONCLUSION: k-t BLAST/k-t SENSE performs at least as well as conventional SENSE for BOLD fMRI at a modest undersampling factor. Results suggest that sufficient sensitivity to BOLD contrast may be achievable at higher undersampling factors with k-t BLAST/k-t SENSE than with conventional parallel imaging approaches, offering particular advantages at the highest magnetic field strengths.
Keywords:fMRI, k-t BLAST/k-t SENSE, SENSE, Parallel Imaging, 3 Tesla, Fast Spin Echo
Source:Journal of Magnetic Resonance Imaging
Page Range:235-241
Date:July 2010
Official Publication:https://doi.org/10.1002/jmri.22212
PubMed:View item in PubMed

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