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| Item Type: | Article |
|---|---|
| Title: | Pre-diagnostic circulating resistin concentrations are not associated with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study |
| Creators: |
Pham, T.T.  ORCID: https://orcid.org/0000-0002-2129-0911, Nimptsch, K. ORCID: https://orcid.org/0000-0001-7877-205X, Aleksandrova, K., Jenab, M. ORCID: https://orcid.org/0000-0002-0573-1852, Reichmann, R., Wu, K., Tjønneland, A. ORCID: https://orcid.org/0000-0003-4385-2097, Kyrø, C. ORCID: https://orcid.org/0000-0002-9083-8960, Schulze, M.B. ORCID: https://orcid.org/0000-0002-0830-5277, Kaaks, R., Katzke, V., Palli, D. ORCID: https://orcid.org/0000-0002-5558-2437, Pasanisi, F. ORCID: https://orcid.org/0000-0003-4224-7821, Ricceri, F. ORCID: https://orcid.org/0000-0001-8749-9737, Tumino, R., Krogh, V. ORCID: https://orcid.org/0000-0003-0122-8624, Roodhart, J., Castilla, J. ORCID: https://orcid.org/0000-0002-6396-7265, Sánchez, M.J. ORCID: https://orcid.org/0000-0003-4817-0757, Colorado-Yohar, S.M. ORCID: https://orcid.org/0000-0002-6700-0780, Harbs, J., Rutegård, M. ORCID: https://orcid.org/0000-0002-0974-6373, Papier, K. ORCID: https://orcid.org/0000-0002-4102-6835, Aglago, E.K. ORCID: https://orcid.org/0000-0002-0442-3284, Dimou, N., Mayen-Chacon, A.L., Weiderpass, E. ORCID: https://orcid.org/0000-0003-2237-0128 and Pischon, T. ORCID: https://orcid.org/0000-0003-1568-767X
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| Abstract: | Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94-1.30; p= 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women. |
| Keywords: | Pre-Diagnostic Resistin, Colorectal Cancer, Risk, Prospective, Inflammation |
| Source: | Cancers |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Volume: | 14 |
| Number: | 22 |
| Page Range: | 5499 |
| Date: | 9 November 2022 |
| Official Publication: | https://doi.org/10.3390/cancers14225499 |
| PubMed: | View item in PubMed |
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