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Interleukin-10-deficient mice develop chronic enterocolitis

Item Type:Article
Title:Interleukin-10-deficient mice develop chronic enterocolitis
Creators Name:Kühn, R., Löhler, J., Rennick, D., Rajewsky, K. and Müller, W.
Abstract:Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL-10-deficient mice, generated by gene targeting, lymphocyte development and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis. Alterations in intestine include extensive mucosal hyperplasia, inflammatory reactions, and aberrant expression of major histocompatibility complex class II molecules on epithelia. In contrast, mutants kept under specific pathogen-free conditions develop only a local inflammation limited to the proximal colon. These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
Keywords:Anemia, Antibody Formation, B-Lymphocytes, Body Weight, Chronic Disease, Enterocolitis, Hematopoietic System, Immunoglobulin A, Immunohistochemistry, Interleukin-10, Intestines, Insertional Mutagenesis, MHC Class II Genes, Mutation, Nematode Infections, Specific Pathogen-Free Organisms, Survival Analysis, T-Lymphocytes, Animals, Mice
Publisher:Cell Press
Page Range:263-274
Date:22 October 1993
Official Publication:https://doi.org/10.1016/0092-8674(93)80068-P
PubMed:View item in PubMed

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