Item Type: | Article |
---|---|
Title: | Adaptive numerical simulation of intracellular calcium dynamics using domain decomposition methods |
Creators Name: | Nagaiah, C., Ruediger, S., Warnecke, G. and Falcke, M. |
Abstract: | In this paper we present adaptive numerical simulations of intracellular calcium dynamics using domain decomposition methods. The modeling of diffusion, binding and membrane transport of calcium ions in cells leads to a system of reaction-diffusions equations. We describe the modulation of cytosolic and ER calcium concentration close to the membrane of the cell organelle. This leads to a two-dimensional model. Local grid refinement is adjusted to the strongly local effects of the calcium dynamics. A finite element method is used for spatial discretization and a Rosenbrock solver for time integration which is third-order accurate and very suitable for nonlinear parabolic problems. We present sequential and parallelized numerical results. The latter are based on domain decomposition methods. |
Keywords: | Inositol Trisphosphate, Ca2+ Dynamics, Oscillations, Elementary, Puffs, Blips, Hepatocytes, Signals, Oocytes, Cells |
Source: | Applied Numerical Mathematics |
ISSN: | 0168-9274 |
Publisher: | Elsevier |
Volume: | 58 |
Number: | 11 |
Page Range: | 1658-1674 |
Date: | November 2008 |
Official Publication: | https://doi.org/10.1016/j.apnum.2007.10.003 |
Repository Staff Only: item control page