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Frequency of elemental events of intracellular Ca(2+) dynamics

Item Type:Article
Title:Frequency of elemental events of intracellular Ca(2+) dynamics
Creators Name:Thul, R. and Falcke, M.
Abstract:The dynamics of intracellular Ca(2+) is driven by random events called Ca(2+) puffs, in which Ca(2+) is liberated from intracellular stores. We show that the emergence of Ca(2+) puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca(2+) puffs has to account for the discrete character of the Ca(2+) release sites and does not permit a continuous description of the number of open channels.
Keywords:Calcium, Calcium Signaling, Intracellular Space, Biological Models
Source:Physical Review E
Publisher:American Physical Society
Number:6 Pt 1
Page Range:061923
Date:June 2006
Official Publication:https://doi.org/10.1103/PhysRevE.73.061923
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