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Transcriptional and translational differences of microglia from male and female brains

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Item Type:Article
Title:Transcriptional and translational differences of microglia from male and female brains
Creators Name:Guneykaya, D., Ivanov, A., Perez Hernandez, D., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., Ochocka, N., Cömert, C., Friedrich, C., Suarez Artiles, L., Kaminska, B., Mertins, P., Beule, D., Kettenmann, H. and Wolf, S.A.
Abstract:Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases, and thus microglia, as the brain's immunocompetent cells, have come into focus in sex-specific studies. Here, we show differences in the structure, function, and transcriptomic and proteomic profiles in microglia freshly isolated from male and female mouse brains. We show that male microglia are more frequent in specific brain areas, have a higher antigen-presenting capacity, and appear to have a higher potential to respond to stimuli such as ATP, reflected in higher baseline outward and inward currents and higher protein expression of purinergic receptors. Altogether, we provide a comprehensive resource to generate and validate hypotheses regarding brain sex differences.
Keywords:Microglia, Sex Differences, Transcriptomics, Proteomics, Animals, Mice
Source:Cell Reports
Publisher:Cell Press / Elsevier
Page Range:2773-2783
Date:4 September 2018
Official Publication:https://doi.org/10.1016/j.celrep.2018.08.001
PubMed:View item in PubMed

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