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| Item Type: | Article |
|---|---|
| Title: | Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19 |
| Creators: |
Suwalski, P.  ORCID: https://orcid.org/0000-0002-2678-2595, Violano, M., Müller, M., Patriki, D., Thibeault, C. ORCID: https://orcid.org/0000-0002-8979-9386, Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H. ORCID: https://orcid.org/0000-0001-5969-2089, Hinzmann, B. ORCID: https://orcid.org/0000-0003-0229-3081, Beer, H.J., Wiggli, B., Siemann, S., Suttorp, N. ORCID: https://orcid.org/0000-0002-3958-1151, Witzenrath, M. ORCID: https://orcid.org/0000-0002-9787-5633, Hippenstiel, S. ORCID: https://orcid.org/0000-0002-5146-1064, Skurk, C. ORCID: https://orcid.org/0000-0003-4953-601X, Poller, W. ORCID: https://orcid.org/0000-0002-2805-6634, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Guettouche, T., Landmesser, U. ORCID: https://orcid.org/0000-0002-0214-3203 and Heidecker, B. ORCID: https://orcid.org/0000-0002-3811-7920
|
| Abstract: | Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex. |
| Keywords: | Genetic, HLA, HLA-C, HLA-C*04:01, COVID-19, Troponin T, hs-TnT |
| Source: | Journal of Cardiovascular Aging |
| ISSN: | 2768-5993 |
| Publisher: | OAE Publishing |
| Volume: | 2 |
| Number: | 3 |
| Page Range: | 33 |
| Date: | 27 June 2022 |
| Official Publication: | https://doi.org/10.20517/jca.2022.19 |
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