Helmholtz Gemeinschaft


Stochastic spreading of intracellular Ca(2+) release

Item Type:Article
Title:Stochastic spreading of intracellular Ca(2+) release
Creators Name:Falcke, M., Tsimring, L. and Levine, H.
Abstract:We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state--stochastic backfiring--was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca(2+) concentration to a lattice of stochastic channel clusters.
Keywords:Calcium, Calcium Channels, Calcium Signaling, Computer Simulation, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Biological Models, Probability, Cytoplasmic and Nuclear Receptors, Stochastic Processes
Source:Physical Review E
Publisher:American Physical Society
Number:2 Pt B
Page Range:2636-2643
Date:August 2000
Official Publication:https://doi.org/10.1103/PhysRevE.62.2636
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library