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| Item Type: | Article |
|---|---|
| Title: | Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension |
| Creators: |
Fischer, R.  ORCID: https://orcid.org/0000-0002-4828-2882, Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080, Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Markovic, M., Feldt, S., Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Park, J.K., Gapelyuk, A., Schwarz, I., Zacharzowsky, U.B., Plehm, R., Safak, E., Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Schirdewan, A., Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Schunck, W.H. ORCID: https://orcid.org/0000-0001-7965-7731 and Mueller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644
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| Abstract: | We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition on electrophysiological remodeling in angiotensin II-induced cardiac injury. We treated double-transgenic rats expressing the human renin and angiotensinogen genes (dTGRs) from week 4 to 7 with n-3 PUFA ethyl-esters (Omacor; 25-g/kg diet) or a direct renin inhibitor (aliskiren; 3 mg/kg per day). Sprague-Dawley rats were controls. We performed electrocardiographic, magnetocardiographic, and programmed electrical stimulation. Dietary n-3 PUFAs increased the cardiac content of eicosapentaenoic and docosahexaenoic acid. At week 7, mortality in dTGRs was 31%, whereas none of the n-3 PUFA- or aliskiren-treated dTGRs died. Systolic blood pressure was modestly reduced in n-3 PUFA-treated (180+/-3 mm Hg) compared with dTGRs (208+/-5 mm Hg). Aliskiren-treated dTGRs and Sprague-Dawley rats were normotensive (110+/-3 and 119+/-6 mm Hg, respectively). Both n-3 PUFA-treated and untreated dTGRs showed cardiac hypertrophy and increased atrial natriuretic peptide levels. Prolonged QRS and QT(c) intervals and increased T-wave dispersion in dTGRs were reduced by n-3 PUFAs or aliskiren. Both treatments reduced arrhythmia induction from 75% in dTGRs to 17% versus 0% in Sprague-Dawley rats. Macrophage infiltration and fibrosis were reduced by n-3 PUFAs and aliskiren. Connexin 43, a mediator of intermyocyte conduction, was redistributed to the lateral cell membranes in dTGRs. n-3 PUFAs and aliskiren restored normal localization to the intercalated disks. Thus, n-3 PUFAs and aliskiren improved electrical remodeling, arrhythmia induction, and connexin 43 expression, despite a 70-mm Hg difference in blood pressure and the development of cardiac hypertrophy. |
| Keywords: | Angiotensin II, Renin inhibition, n-3 PUFA, Arrhythmias, Magnetocardiography, Animals, Rats |
| Source: | Hypertension |
| ISSN: | 0194-911X |
| Publisher: | American Heart Association |
| Volume: | 51 |
| Number: | 2 |
| Page Range: | 540-546 |
| Date: | February 2008 |
| Official Publication: | https://doi.org/10.1161/HYPERTENSIONAHA.107.103143 |
| PubMed: | View item in PubMed |
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