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CORG: a database for COmparative Regulatory Genomics

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Item Type:Article
Title:CORG: a database for COmparative Regulatory Genomics
Creators Name:Dieterich, C., Wang, H., Rateitschak, K., Luz, H. and Vingron, M.
Abstract:Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.
Keywords:Conserved Sequence, Nucleic Acid Databases, Gene Expression Regulation, Human Genome, Genomics, Internet, Nucleic Acid Regulatory Sequences, Sequence Alignment, DNA Sequence Analysis, Genetic Transcription, Animals, Mice
Source:Nucleic Acids Research
Publisher:Oxford University Press
Page Range:55-57
Official Publication:https://doi.org/10.1093/nar/gkg007
PubMed:View item in PubMed

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