Browse by Research Team

2024

Renin is essential for angiotensin II formation in the brain.
Rodrigues, A.F., Domenig, O., Garrelds, I.M., Danser, J.A.H., Alenina, N., Poglitsch, M. and Bader, M.
Journal of the American Heart Association 13 (22): e034209. 19 November 2024

Transgenic rat with ubiquitous expression of angiotensin-(1-7)-producing fusion protein: a new tool to study the role of protective arm of the renin-angiotensin system in the pathophysiology of cardio-renal diseases.
Červenka, L., Husková, Z., Kikerlová, S., Gawrys, O., Vacková, Š., Škaroupková, P., Sadowski, J., Miklovič, M., Molnár, M., Táborský, M., Melenovský, V. and Bader, M.
Hypertension Research 13 November 2024 (In Press)

Normal male fertility in a mouse model of KPNA2 deficiency.
Rother, F., Abu Hweidi, D., Hartmann, E. and Bader, M.
PLoS ONE 19 (10): e0304189. 18 October 2024

Serotonin drives aggression and social behaviours of laboratory mice in a semi-natural environment.
Rivalan, M., Alonso, L., Mosienko, V., Bey, P., Hyde, A., Bader, M., Winter, Y. and Alenina, N.
Frontiers in Behavioral Neuroscience 18 18 September 2024

ACE2 knockout mice are resistant to high-fat diet-induced obesity in an age-dependent manner.
Nunes-Souza, V., Alenina, N., Qadri, F., Mosienko, V., Santos, R.A.S., Bader, M. and Rabelo, L.A.
International Journal of Molecular Sciences 25 (17): 9515. 1 September 2024

Angiotensin-(1-12): does it exist? A critical evaluation in humans, rats, and mice.
Rodrigues, A.F., Domenig, O., Poglitsch, M., Bader, M. and Danser, A.H.J.
Hypertension 81 (8): 1776-1784. August 2024

Novel tryptophan hydroxylase inhibitor TPT-001 reverses PAH, vascular remodeling, and proliferative-proinflammatory gene expression.
Legchenko, E., Chouvarine, P., Qadri, F., Specker, E., Nazaré, M., Wesolowski, R., Matthes, S., Bader, M. and Hansmann, G.
JACC: Basic to Translational Science 9 (7): 890-902. July 2024

Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.
Botoni, F.A., Lambertucci, J.R., Santos, R.A.S., Müller, J., Talvani, A. and Wallukat, G.
Frontiers in Immunology 15 : 1404384. 17 June 2024

Role of kinin receptors in skin pigmentation.
Ferreira, J.C.P., Soley, B.S., Pawloski, P.L., Moreira, C.G., Pesquero, J.B., Bader, M., Calixto, J.B., Cabrini, D.A. and Otuki, M.F.
European Journal of Pharmacology 973 : 176537. 15 June 2024

TPT-004, a next-generation inhibitor of tryptophan hydroxylase, ameliorates pulmonary arterial hypertension in rats.
Wesolowski, R., Pleimes, D., Specker, E. and Bader, M.
Journal of the American Heart Association 13 (10): e034240. 21 May 2024

Alternative renin-angiotensin system.
Bader, M., Muscha Steckelings, U., Alenina, N., Santos, R.A.S. and Ferrario, C.M.
Hypertension 81 (5): 964-976. May 2024

Poor decision making and sociability impairment following central serotonin reduction in inducible TPH2-knockdown rats.
Alonso, L., Peeva, P., Fernández-del Valle Alquicira, T., Erdelyi, N., Gil Nolskog, Á., Bader, M., Winter, Y., Alenina, N. and Rivalan, M.
International Journal of Molecular Sciences 25 (9): 5003. May 2024

Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice.
Rother, F., Depping, R., Popova, E., Huegel, S., Heiler, A., Hartmann, E. and Bader, M.
FASEB Journal 38 (8): e23623. 30 April 2024

Anxiolytic effect of alamandine in male transgenic rats with low brain angiotensinogen is dependent on activation of MrgD receptors.
Amado Costa, L., Oliveira Amaral, L.B., Mourão, F.A.G., Bader, M., Santos, R.A.S., Campagnole-Santos, M.J. and Kangussu, L.M.
Hormones and Behavior 163 : 105551. 27 April 2024

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Bolduan, F., Wetzel, A., Giesecke, Y., Eichhorn, I., Alenina, N., Bader, M., Willnow, T.E., Wiedenmann, B. and Sigal, M.
Frontiers in Endocrinology 15 : 1331231. 17 April 2024

Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma.
Yalcin, F., Haneke, H., Efe, I.E., Kuhrt, L.D., Motta, E., Nickl, B., Flüh, C., Synowitz, M., Dzaye, O., Bader, M. and Kettenmann, H.
Acta Neuropathologica Communications 12 (1): 50. 2 April 2024

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome.
Chan, J.C., Alenina, N., Cunningham, A.M., Ramakrishnan, A., Shen, Li, Bader, M. and Maze, I.
Journal of Molecular Biology 436 (7): 168454. 1 April 2024

Effects of bradykinin B2 receptor ablation from tyrosine hydroxylase cells on behavioral and motor aspects in male and female mice.
Franco, T.M., Tavares, M.R., Novaes, L.S., Munhoz, C.D., Peixoto-Santos, J.E., Araujo, R.C., Donato, J., Bader, M. and Wasinski, F.
International Journal of Molecular Sciences 25 (3): 1490. 25 January 2024

Kinin B1 receptor modulates glucose homeostasis and physical exercise capacity by altering adrenal catecholamine synthesis and secretion.
Gregnani, M.F., Budu, A., Batista, R.O., Ornellas, F.H., Estrela, G.R., Arruda, A.C., Freitas-Lima, L.C., Kremer, J.L., Favaroni Mendes, L.A., Casarini, D.E., Lotfi, C.F.P., Oyama, L.M., Bader, M. and Araujo, R.C.
Molecular and Cellular Endocrinology 579 : 112085. 1 January 2024

Tail-cuff versus radiotelemetry to measure blood pressure in mice and rats.
Harrison, D.G., Bader, M., Lerman, L.O., Fink, G., Karumanchi, S.A., Reckelhoff, J.F., Sequeira-Lopez, M.L.S. and Touyz, R.M.
Hypertension 81 (1): 3-5. January 2024

2023

GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats.
Azizian, H., Farhadi, Z., Bader, M., Ghalenoei, J.A., Ghafari, M.A. and Mahmoodzadeh, S.
PLoS ONE 18 (12): e0293630. 22 December 2023

Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain.
Alves-Silva, T., Húngaro, T.G.R., Freitas-Lima, L.C., de Melo Arthur, G., Arruda, A.C., Santos, R.B., Oyama, L.M., Mori, M.A.S., Bader, M. and Araujo, R.C.
iScience 26 (12): 108409. 15 December 2023

Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT(2C) receptor in the mouse brain.
Zaniewska, M., Alenina, N., Fröhler, S., Chen, W. and Bader, M.
Pharmacological Reports 75 (6): 1502-1521. December 2023

The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats.
Haduch, A., Bromek, E., Kuban, W., Basińska-Ziobroń, A., Danek, P.J., Alenina, N., Bader, M. and Daniel, W.A.
Pharmacological Reports 75 (6): 1522-1532. December 2023

Structure-based design of xanthine-imidazopyridines and -imidazothiazoles as highly potent and in vivo efficacious tryptophan hydroxylase inhibitors.
Specker, E., Wesolowski, R., Schütz, A., Matthes, S., Mallow, K., Wasinska-Kalwa, M., Winkler, L., Oder, A., Alenina, N., Pleimes, D., von Kries, J.P., Heinemann, U., Bader, M. and Nazaré, M.
Journal of Medicinal Chemistry 66 (21): 14866-14896. 9 November 2023

Kinins: Locally formed peptides during inflammation with potential use in tissue regeneration.
Martins, L., Bader, M. and Pesquero, J.B.
Inflammation Research 72 (10-11): 1957-1963. November 2023

The contribution of the AT1 receptor to erythropoiesis.
Rodrigues, A.F. and Bader, M.
Biochemical Pharmacology 217 : 115805. November 2023

Functional assay for assessment of agonistic or antagonistic activity of angiotensin AT(2) receptor ligands reveals that EMA401 and PD123319 have agonistic properties.
Peluso, A.A., Souza Silva, I.M., Villela, D.C., Hansen, P.B.L., Hallberg, A., Bader, M., Santos, R., Sumners, C. and Muscha Steckelings, U.
Biochemical Pharmacology 216 : 115793. October 2023

Cardiovascular peptide hormones - special edition.
Braga, T.V., Mervaala, E., Santos, R. and Bader, M.
Peptides 167 : 171062. September 2023

G-protein-coupled receptor MAS DeLETION produces a preeclampsia-like phenotype in FVB/N mice.
Vieira Pimentel, R.L., Braga, J.F., Velloso, E.P.P., Lautner, R.Q., Oliveira, M.L., Todiras, M., Alenina, N., Bader, M., de Sousa, F.G., Beier, S.L. and Souza Dos Santos, R.A.
Clinical Science 137 (16): 1249-1263. August 2023

Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
Martins, L., Amorim, W.W., Gregnani, M.F., de Carvalho Araújo, R., Qadri, F., Bader, M. and Pesquero, J.B.
Inflammation Research 72 (8): 1583-1601. August 2023

Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104 (2): 388-393. August 2023

Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury.
Sanad, A.M., Qadri, F., Popova, E., Rodrigues, A.F., Heinbokel, T., Quach, S., Schulz, A., Bachmann, S., Kreutz, R., Alenina, N. and Bader, M.
Kidney International 104 (2): 293-304. August 2023

Angiotensin deficient FVB/N mice are normotensive.
Rodrigues, A.F., Todiras, M., Qadri, F., Alenina, N. and Bader, M.
British Journal of Pharmacology 180 (14): 1843-1861. July 2023

Angiotensin-(1-7) mediated calcium signalling by MAS.
Sureshkumar, P., Souza dos Santos, R.A., Alenina, N., Mergler, S. and Bader, M.
Peptides 165 : 171010. July 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
Cerri, G.C., Santos, S.H.S., Bader, M. and Dos Santos, R.A.S.
Journal of nutritional biochemistry 114 : 109268. April 2023

Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria.
Kourpa, A., Schulz, A., Mangelsen, E., Kaiser-Graf, D., Koppers, N., Stoll, M., Rothe, M., Bader, M., Purfürst, B., Kunz, S., Gladytz, T., Niendorf, T., Bachmann, S., Mutig, K., Bolbrinker, J., Panakova, D. and Kreutz, R.
Hypertension 80 (4): 771-782. April 2023

Tryptophan hydroxylase-2-mediated serotonin biosynthesis suppresses cell reprogramming into pluripotent state.
Sinenko, S.A., Kuzmin, A.A., Skvortsova, E.V., Ponomartsev, S.V., Efimova, E.V., Bader, M., Alenina, N. and Tomilin, A.N.
International Journal of Molecular Sciences 24 (5): 4862. 2 March 2023

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitive abilities.
Alonso, L., Peeva, P., Stasko, S., Bader, M., Alenina, N., Winter, Y. and Rivalan, M.
iScience 26 (2): 105998. 17 February 2023

Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion.
Li, K., Kratzmann, V., Dai, M., Gatzke, N., Rocic, P., Bramlage, P., Grisk, O., Lubomirov, L.T., Hoffmeister, M., Lauxmann, M.A., Ritter, O., Buschmann, E., Bader, M., Persson, A.B., Buschmann, I. and Hillmeister, P.
Frontiers in Cardiovascular Medicine 9 : 981333. 3 February 2023

B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia.
Herrock, O.T., Deer, E., Amaral, L.M., Campbell, N., Lemon, J., Ingram, N., Cornelius, D.C., Turner, T., Fitzgerald, S., Ibrahim, T., Dechend, R., Wallukat, G. and LaMarca, B.
American Journal of Physiology Renal Physiology 324 (2): F179-F192. February 2023

Circulating angiotensin II type I receptor – autoantibodies in diabetic pregnancies.
Linge, L.L., Sugulle, M., Wallukat, G., Dechend, R. and Staff, A.C.
Journal of Reproductive Immunology 155 : 103777. February 2023

Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
Becari, L., Fonseca, M.L.A., Gonçalves, S.C.A, Bader, M., Santos, R.A.S., Campagnole-Santos, M.J. and Kangussu, L.M.
Acta Neuropsychiatrica 35 (1): 27-34. February 2023

Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.
Jansch, M., Lubomirov, L.T., Trum, M., Williams, T., Schmitt, J., Schuh, K., Qadri, F., Maier, L.S., Bader, M. and Ritter, O.
FEBS Open Bio 13 (1): 118-132. January 2023

Transgenic rat with overproduction of ubiquitous angiotensin-(1-7) presents neuroprotection in a model of ischemia and reperfusion.
Kangussu, L.M., Almeida-Santos, A.F., Fernandes, L.F., Alenina, N., Bader, M., Santos, R.A.S., Massensini, A.R. and Campagnole-Santos, M.J.
Brain Research Bulletin 192 : 184-191. January 2023

In vitro galactose impairs energy metabolism in the brain of young rats: protective role of antioxidants.
Delwing-de Lima, D., Sasso, S., Delwing-Dal Magro, D., Pereira, N.R., Rodrigues, A.F., Schmitz, F., Manoel Pereira, E., Schramm do Nascimento, M.A. and Wyse, A.T.S.
Nucleosides Nucleotides & Nucleic Acids 42 (12): 967-985. 2023

Transgenic animal models for the functional analysis of ACE2.
Alenina, N. and Bader, M.
In: Angiotensin : from the kidney to coronavirus. Molecular Mediators in Health and Disease: How Cells Communicate . Elsevier / Academic Press, London, 491-503. ISBN 978-0-323-99618-1 2023

2022

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function.
Dueck, A., Althaus, L., Heise, K., Esfandyari, D., Bayguen, S., Brandes, R.P., Gagneur, J., Jae, N., Knolle, P., Leisegang, M.S., Maegdefessel, L., Meitinger, T., Petzold, N., Ramanujam, D., Sager, H., Schulz, C., Theodorakis, E., Uzonyi, A., Weinberger, T., Bader, M., Schmidt-Supprian, M. and Engelhardt, S.
bioRxiv : 2022.11.30.518576. 22 December 2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Angiotensin 1-7 increases fiber cross sectional area and force in juvenile mouse skeletal muscle.
Albadrani, H., Ammar, T., Rajgara, R., Bader, M., Wiper-Bergeron, N. and Renaud, J.M.
American Journal of Physiology Cell Physiology 323 (6): C1681-C1696. December 2022

Kinin B1 receptor modulates mitochondrial activity responsivity in fasting and voluntary exercise.
Arruda, A.C., Budu, A., de Menezes, T.N., Bader, M., Araujo, R.C. and Freitas-Lima, L.C.
Life Sciences 309 : 121034. 15 November 2022

Quantitative phosphoproteomics of the angiotensin AT(2)-receptor signaling network identifies HDAC1 (Histone-Deacetylase-1) and p53 as mediators of antiproliferation and apoptosis.
Peluso, A.A.B., Kempf, S.J., Verano-Braga, T., Rodrigues-Ribeiro, L., Johansen, L.E., Hansen, M.R., Kitlen, G., Haugaard, A.H., Sumners, C., Ditzel, H.J., Santos, R.A., Bader, M., Larsen, M.R. and Steckelings, U.M.
Hypertension 79 (11): 2530-2541. November 2022

Functional antibodies against G-protein coupled receptors in Beagle dogs infected with two different strains of Trypanosoma cruzi.
Wallukat, G., Botoni, F.A., Rocha, M.O.C., Louise, V., Müller, J. and Talvani, A.
Frontiers in Immunology 13 : 926682. 25 October 2022

Role of Gpnmb in atherosclerosis of female mice.
Nickl, B., Qadri, F. and Bader, M.
Biochemical and Biophysical Research Communications 621 : 20-24. 17 September 2022

In vivo skin regeneration and wound healing using cell micro-transplantation.
Nanić, L., Cedilak, A., Vidaček, N.Š., Gruber, F., Huzak, M., Bader, M. and Rubelj, I.
Pharmaceutics 14 (9): 1955. 15 September 2022

Why angiotensin II is a poor choice for circulatory support of ventilated COVID-19 patients compared to vasopressin.
Speth, R.C. and Bader, M.
Medical Research Archives 10 (9): 3079. September 2022

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors.
Specker, E., Matthes, S., Wesolowski, R., Schütz, A., Grohmann, M., Alenina, N., Pleimes, D., Mallow, K., Neuenschwander, M., Gogolin, A., Weise, M., Pfeifer, J., Ziebart, N., Heinemann, U., von Kries, J.P., Nazaré, M. and Bader, M.
Journal of Medicinal Chemistry 65 (16): 11126-11149. 25 August 2022

Editorial: Sexual dimorphism in biomedical research and its therapeutic implications.
Kroon, J., Mahmoodzadeh, S. and Helsen, C.
Frontiers in Endocrinology 13 : 1009712. 19 August 2022

Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein.
Mohamed, B.A., Elkenani, M., Mobarak, S., Marques Rodrigues, D., Annamalai, K., Schnelle, M., Bader, M., Hasenfuss, G. and Toischer, K.
Journal of Cellular and Molecular Medicine 26 (16): 4440-4452. August 2022

Role of endothelial kinin B(1) receptor on the membrane potential of transgenic rat aorta.
Batista, C., Sales, V.M., Merino, V.F., Bader, M., Feres, T. and Pesquero, J.B.
Physiological Research 71 (4): 477-487. August 2022

Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.
Bekassy, Z., Lopatko Fagerström, I., Bader, M. and Karpman, D.
Nature Reviews Immunology 22 (7): 411-428. July 2022

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.
Batlle, D., Monteil, V., Garreta, E., Hassler, L., Wysocki, J., Chandar, V., Schwartz, R.E., Mirazimi, A., Montserrat, N., Bader, M. and Penninger, J.M.
Cell 185 (11): 1837-1839. 26 May 2022

Serotonin limits generation of chromaffin cells during adrenal organ development.
Kameneva, P., Melnikova, V.I., Kastriti, M.E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A.V., Kalinina, T.S., Kudryashov, N.V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P., Yakushov, V.D., Sheftel, B.I., Zikmund, T., Kaiser, J., Fried, K., Alenina, N., Voronezhskaya, E.E. and Adameyko, I.
Nature Communications 13 (1): 2901. 25 May 2022

Peripheral serotonin deficiency affects anxiety-like behavior and the molecular response to an acute challenge in rats.
Sbrini, G., Hanswijk, S.I., Brivio, P., Middelman, A., Bader, M., Fumagalli, F., Alenina, N., Homberg, J.R. and Calabrese, F.
International Journal of Molecular Sciences 23 (9): 4941. 29 April 2022

Oxidative RNA damage in the pathogenesis and treatment of type 2 diabetes.
Chen, X., Yu, H., Li, Z., Ye, W., Liu, Z., Gao, J., Wang, Y., Li, X., Zhang, L., Alenina, N., Bader, M., Ding, H., Li, P. and Aung, L.H.H.
Frontiers in Physiology 13 : 725919. 28 March 2022

Tph2 gene expression defines ethanol drinking behavior in mice.
Zaniewska, M., Mosienko, V., Bader, M. and Alenina, N.
Cells 11 (5): 874. 3 March 2022

Placental CD4(+) T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia.
Reeve, K.E., Deer, E., Amaral, L.M., Cornelius, D.C., Herrock, O., Harmon, A.C., Campbell, N., Fitzgerald, S., Ibrahim, T., Wallukat, G., Dechend, R. and LaMarca, B.
Exploration of Medicine 3 : 99-111. 25 February 2022

Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Mohammed, M., Johnson, D.N., Wang, L.A., Harden, S.W., Sheng, W., Spector, E.A., Elsaafien, K., Bader, M., Steckelings, U.M., Scott, K.A., Frazier, C.J., Sumners, C., Krause, E.G. and de Kloet, A.D.
Cardiovascular Research 118 (3): 883-896. 21 February 2022

Myogenic vasoconstriction requires canonical G(q/11) signaling of the angiotensin II type 1 receptor.
Cui, Y., Kassmann, M., Nickel, S., Zhang, C., Alenina, N., Anistan, Y.M., Schleifenbaum, J., Bader, M., Welsh, D.G., Huang, Y. and Gollasch, M.
Journal of the American Heart Association 11 (4): e022070. 15 February 2022

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visually triggered locomotive enhancement in mice upon optogenetic stimulation.
Araragi, N., Alenina, N. and Bader, M.
Heliyon 8 (1): e08692. January 2022

Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
Grabowski, K., Herlan, L., Witten, A., Qadri, F., Eisenreich, A., Lindner, D., Schädlich, M., Schulz, A., Subrova, J., Mhatre, K.N., Primessnig, U., Plehm, R., van Linthout, S., Escher, F., Bader, M., Stoll, M., Westermann, D., Heinzel, F.R. and Kreutz, R.
Hypertension Research 45 : 292-307. January 2022

Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats.
Haduch, A., Danek, P.J., Kuban, W., Pukło, R., Alenina, N., Gołębiowska, J., Popik, P., Bader, M. and Daniel, W.A.
Neurochemistry International 152 : 105223. January 2022

2021

(Pro)renin receptor inhibition reduces plasma cholesterol and triglycerides but does not attenuate atherosclerosis in atherosclerotic mice.
Ye, D., Yang, X., Ren, L., Lu, H.S., Sun, Y., Lin, H., Tan, L., Wang, N., Nguyen, G., Bader, M., Mullick, A.E., Danser, A.H.J., Daugherty, A., Jiang, Y., Sun, Y., Li, F. and Lu, X.
Frontiers in Cardiovascular Medicine 8 : 725203. 24 December 2021

Angiotensin 1-7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle.
Albadrani, H., Ammar, T., Bader, M. and Renaud, J.M.
Journal of General Physiology 153 (12): e201912556. 6 December 2021

Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Golic, M. and Kräker, K.
Diabetologia 64 (12): 2829-2842. December 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

The receptor AT1 appears to be important for the maintenance of bone mass and AT2 receptor function in periodontal bone loss appears to be regulated by AT1 receptor.
Lima, M.L.S., Martins, A.A., Medeiros, C.A.C.X., Guerra, G.C.B., Santos, R., Bader, M., Pirih, F.Q., Araújo Júnior, R.F., Brito, G.A.C., Leitão, R.F.C., Silva, R.A., Barbosa, S.J.A., Melo, R.C.O. and Araújo, A.A.
International Journal of Molecular Sciences 22 (23): 12849. 27 November 2021

Enduring effects of conditional brain serotonin knockdown, followed by recovery, on adult rat neurogenesis and behavior.
Sidorova, M., Kronenberg, G., Matthes, S., Petermann, M., Hellweg, R., Tuchina, O., Bader, M., Alenina, N. and Klempin, F.
Cells 10 (11): 3240. 19 November 2021

In vivo renin activity imaging in the kidney of progeroid Ercc1 mutant mice.
van Thiel, B.S., van der Linden, J., Ridwan, Y., Garrelds, I.M., Vermeij, M., Clahsen-van Groningen, M.C., Qadri, F., Alenina, N., Bader, M., Roks, A.J.M., Danser, A.H.J., Essers, J. and van der Pluijm, I.
International Journal of Molecular Sciences 22 (22): 12433. 18 November 2021

Anti-inflammatory role of Gpnmb in adipose tissue of mice.
Nickl, B., Qadri, F. and Bader, M.
Scientific Reports 11 (1): 19614. 4 October 2021

Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
Liu, N., Qadri, F., Busch, H., Huegel, S., Sihn, G., Chuykin, I., Hartmann, E., Bader, M. and Rother, F.
Development 148 (19): dev.198374. 1 October 2021

Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex.
Marins, F.R., Oliveira, A.C., Qadri, F., Motta-Santos, D., Alenina, N., Bader, M., Fontes, M.A.P. and Souza Santos, R.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 321 (3): R513-R521. 10 September 2021

Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein.
Alves, D.T., Mendes, L.F., Sampaio, W.O., Coimbra-Campos, L.M.C., Vieira, M.A.R., Ferreira, A.J., Martins, A.S., Popova, E., Todiras, M., Qadri, F., Alenina, N., Bader, M., Santos, R.A.S. and Campagnole-Santos, M.J.
Clinical Science 135 (18): 2197-2216. 8 September 2021

The continued need for animals to advance brain research.
Homberg, J.R., Adan, R.A.H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., van Dijk, G., Eisel, U.L.M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., van Dam, A.M., Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Kasri, N.N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D.A., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., de la Prida, L.M., Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L.J.M.J., Takeuchi, T., van der Veen, R., Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., van der Zee, E.A. and Genzel, L.
Neuron 109 (15): 2374-2379. 4 August 2021

Cortisol dose-dependently impairs migration and tube-like formation in a trophoblast cell line and modulates inflammatory and angiogenic genes.
Húngaro, T.G.R, Gregnani, M.F., Alves-Silva, T., Herse, F., Alenina, N., Bader, M. and Araújo, R.C.
Biomedicines 9 (8): 980. August 2021

The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
Figueiredo, M., Daryadel, A., Sihn, G., Müller, D.N., Popova, E., Rouselle, A., Nguyen, G., Bader, M. and Wagner, C.A.
Pflugers Archiv 473 : 1229-1246. August 2021

The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons.
Borroto-Escuela, D.O., Ferraro, L., Beggiato, S., Narváez, M., Fores-Pons, R., Alvarez-Contino, J.E., Wydra, K., Frankowska, M., Bader, M., Filip, M. and Fuxe, K.
Pharmacological Reports 73 (4): 1096-1108. August 2021

Community-wide experimental evaluation of the PROSS stability-design method.
Peleg, Y., Vincentelli, R., Collins, B.M., Chen, K.E., Livingstone, E.K., Weeratunga, S., Leneva, N., Guo, Q., Remans, K., Perez, K., Bjerga, G.E.K., Larsen, Ø., Vaněk, O., Skořepa, O., Jacquemin, S., Poterszman, A., Kjaer, S., Christodoulou, E., Albeck, S., Dym, O., Ainbinder, E., Unger, T., Schuetz, A., Matthes, S., Bader, M., de Marco, A., Storici, P., Semrau, M.S., Stolt-Bergner, P., Aigner, C., Suppmann, S., Goldenzweig, A. and Fleishman, S.J.
Journal of Molecular Biology 433 (13): 166964. 25 June 2021

Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis.
Rodrigues, A.F., Todiras, M., Qadri, F., Campagnole-Santos, M.J., Alenina, N. and Bader, M.
Clinical Science 135 (11): 1353-1367. 2 June 2021

Phenylalanine-hydroxylase contributes to serotonin synthesis in mice.
Mordhorst, A., Dhandapani, P., Matthes, S., Mosienko, V., Rothe, M., Todiras, M., Self, J., Schunck, W.H., Schütz, A., Bader, M. and Alenina, N.
FASEB Journal 35 (6): e21648. June 2021

Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy.
Ku, M.C., Kober, F., Lai, Y.C., Pohlmann, A., Qadri, F., Bader, M., Carrier, L. and Niendorf, T.
Journal of Cardiovascular Magnetic Resonance 23 (1): 63. 31 May 2021

AT1 and AT2 receptor knockout changed osteonectin and bone density in mice in periodontal inflammation experimental model.
Lima, M.L.S., Medeiros, C.A.C.X., Guerra, G.C.B., Santos, R., Bader, M., Pirih, F.Q., Araújo Júnior, R.F., Chan, A.B., Cruz, L.J., Brito, G.A.C., Leitão, R.F.C., Silveira, EJ.D., Garcia, V.B., Martins, A.A. and Araújo, A.A.
International Journal of Molecular Sciences 22 (10): 5217. 14 May 2021

Agonistic autoantibodies against β2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients.
Hohberger, B., Hosari, S., Wallukat, G., Kunze, R., Krebs, J., Müller, M., Hennig, T., Lämmer, R., Horn, F., Muñoz, L.E., Herrmann, M. and Mardin, C.
PLoS ONE 16 (5): e0249202. 7 May 2021

Agonistic β2-adrenergic receptor autoantibodies characterize the aqueous humor of patients with primary and secondary open-angle glaucoma.
Hohberger, B., Wörn, M., Lämmer, R., Mahajan, A., Mardin, C., Schötzer-Schrehardt, U., Kunze, R., Herrmann, M. and Wallukat, G.
Frontiers in Immunology 12 : 550236. 5 May 2021

Alterations in BDNF protein concentrations in the hippocampus do not explain the pro-neurogenic effect of citalopram on adult neurogenesis.
Petermann, M., Kronenberg, G., Mosienko, V., Bader, M., Alenina, N., Hellweg, R. and Klempin, F.
Pharmacopsychiatry 54 (3): 101-105. May 2021

Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Marahrens, B., Schulze, A., Wysocki, J., Lin, M.H., Ye, M., Kanwar, Y.S., Bader, M., Velez, J.C.Q., Miner, J.H. and Batlle, D.
Kidney International 99 (4): 900-913. April 2021

Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival.
Muzerelle, A., Soiza-Reilly, M., Hainer, C., Ruet, P.L., Lesch, K.P., Bader, M., Alenina, N., Scotto-Lomassese, S. and Gaspar, P.
Scientific Reports 11 (1): 6004. 16 March 2021

Genetic deletion of trace-amine associated receptor 9 (TAAR9) in rats leads to decreased blood cholesterol levels.
Murtazina, R.Z., Zhukov, I.S., Korenkova, O.M., Popova, E.A., Kuvarzin, S. R., Efimova, E.V., Kubarskaya, L.G., Batotsyrenova, E.G., Zolotoverkhaya, E.A., Vaganova, A.N., Apryatin, S.A., Alenina, N.V. and Gainetdinov, R.R.
International Journal of Molecular Sciences 22 (6): 2942. 2 March 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

Intrauterine exposure to diabetic milieu does not induce diabetes and obesity in male adulthood in a novel rat model.
Schütte, T., Kedziora, S.M., Haase, N., Herse, F., Busjahn, A., Birukov, A., Alenina, N., Müller, D.N., Bader, M., Schupp, M., Dechend, R., Kräker, K. and Golic, M.
Hypertension 77 (1): 202-215. January 2021

Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection.
Melo, E.M., Del Sarto, J., Vago, J.P., Tavares, L.P., Rago, F., Gonçalves, A.P.F., Machado, M.G., Aranda-Pardos, I., Valiate, B.V.S., Cassali, G.D., Pinho, V., Sousa, L.P., A-Gonzalez, N., Campagnole-Santos, M.J., Bader, M., Santos, R.A.S., Machado, A.V., Ludwig, S. and Teixeira, M.M.
Pharmacological Research 163 : 105292. January 2021

Bradykinin receptors.
Maghsodi, S., Qadri, F. and Bader, M.
In: Reference Module in Life Sciences. Encyclopedia of Biological Chemistry III (Third Edition), 6 . Elsevier, 142-160. ISBN 978-0-12-822040-5 2021

Renin-angiotensin-aldosterone system.
Bader, M.
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 1353-1358. ISBN 978-3-030-57400-0 2021

2020

Paternal exercise protects against liver steatosis in the male offspring of mice submitted to high fat diet.
Batista, R.O., Budu, A., Alves-Silva, T., Arakaki, A.M., Gregnani, M.F.S., Rodrigues Húngaro, T.G., Burgos-Silva, M., Wasinski, F., Lanzoni, V.P., Camara, N.O.S., Oyama, L.M., Bader, M. and Araújo, R.C.
Life Sciences 263 : 118583. 15 December 2020

ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19.
Bader, M., Turner, A.J. and Alenina, N.
Clinical Science 134 (23): 3229-3232. 11 December 2020

Angiotensin-(1-7) prevents lipopolysaccharide-induced autophagy via the Mas receptor in skeletal muscle.
Rivera, J.C., Abrigo, J., Tacchi, F., Simon, F., Brandan, E., Santos, R.A., Bader, M., Chiong, M. and Cabello-Verrugio, C.
International Journal of Molecular Sciences 21 (24): 9344. 8 December 2020

The effect of ageing and cerebral serotonin deficit on the activity of cytochrome P450 2D (CYP2D) in the brain and liver of male rats.
Haduch, A., Pukło, R., Alenina, N., Nikiforuk, A., Popik, P., Bader, M. and Daniel, W.A.
Neurochemistry International 141 : 104884. December 2020

ACE2 - das missbrauchte Multitalent [ACE2 - the hijacked all-rounder].
Bader, M.
Nephrologe 15 (6): 375-380. November 2020

Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Ni, J., Yang, F., Huang, X.R., Meng, J., Chen, J., Bader, M., Penninger, J.M., Fung, E., Yu, X.Q. and Lan, H.Y.
Journal of Cellular and Molecular Medicine 24 (22): 13093-13103. November 2020

Neurobiology of glycine transporters: from molecules to behavior.
Marques, B.L., Oliveira-Lima, O.C., Carvalho, G.A., de Almeida Chiarelli, R., Ribeiro, R.I., Parreira, R.C., da Madeira Freitas, E.M., Resende, R.R., Klempin, F., Ulrich, H., Gomez, R.S. and Pinto, M.C.X.
Neuroscience and Biobehavioral Reviews 118 : 97-110. November 2020

Myogenic vasoconstriction requires canonical Gq/11 signaling of the angiotensin II type 1a receptor in the murine vasculature.
Cui, Y., Kassmann, M., Nickel, S., Zhang, C., Alenina, N., Anistan, Y.M., Schleifenbaum, J., Bader, M., Welsh, D.G., Huang, Y. and Gollasch, M.
bioRxiv : 2020.09.09.289280. 11 September 2020

Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes.
Kräker, K., Herse, F., Golic, M., Reichhart, N., Crespo-Garcia, S., Straß, O., Grune, J., Kintscher, U., Ebrahim, M., Bader, M., Alenina, N., Heuser, A., Luft, F.C., Müller, D.N., Dechend, R. and Haase, N.
Scientific Reports 10 (1): 14061. 20 August 2020

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L., Panayotis, N., Alber, S., Dagan, S.Y., Okladnikov, N., Koppel, I., Di Pizio, A., Song, D.A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M. and Fainzilber, M.
Science 369 (6505): 842-846. 14 August 2020

Bradykinin B2 receptor signaling increases glucose uptake and oxidation: evidence and open questions.
Gregnani, M.F., Hungaro, T.G., Martins-Silva, L., Bader, M. and Araujo, R.C.
Frontiers in Pharmacology 11 : 1162. 4 August 2020

Angiotensin‐II receptor type Ia does not contribute to cardiac atrophy following high‐thoracic spinal cord injury in mice.
Järve, A., Qadri, F., Todiras, M., Schmolke, S. and Bader, M.
Experimental Physiology 105 (8): 1316-1325. 1 August 2020

Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira, M., Ferreira, D.G., Batalha, V.L., Marques-Morgado, I., Coelho, J.E., Pereira, P., Gomes, R., Pinto, A., Carvalho, S., Canas, P.M., Cuvelier, L., Buée-Scherrer, V., Faivre, E., Baqi, Y., Müller, C.E., Pimentel, J., Schiffmann, S.N., Buée, L., Bader, M., Outeiro, T.F., Blum, D., Cunha, R.A., Marie, H., Pousinha, P.A. and Lopes, L.V.
Molecular Psychiatry 25 (8): 1876-1900. August 2020

B(1) and B(2) kinin receptor blockade improves psoriasis-like disease.
da Silva Soley, B., Silva, L.M., Mendes, D.A.G.B., Báfica, A., Pesquero, J.B., Bader, M., Witherden, D.A., Havran, W.L., Calixto, J.B., Otuki, M.F. and Cabrini, D.A.
British Journal of Pharmacology 177 (15): 3535-3551. August 2020

Genetic deletion of the angiotensin-(1-7) receptor mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
Oliveira, L.P., Guimarães, V.H.D., Oliveira, J.R., Guimarães, A.L.S., de Paula, A.M.B., Bader, M., dos Santos, R.A.S. and Santos, S.H.S.
Neuropeptides 82 : 102056. August 2020

The dual role of serotonin in colorectal cancer.
Kannen, V., Bader, M., Sakita, J.Y., Uyemura, S.A. and Squire, J.A.
Trends in Endocrinology and Metabolism 31 (8): 611-625. August 2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

The absence of serotonin in the brain alters acute stress responsiveness by interfering with the genomic function of the glucocorticoid receptors.
Sbrini, G., Brivio, P., Peeva, P.M., Todiras, M., Bader, M., Alenina, N. and Calabrese, F.
Frontiers in Cellular Neuroscience 14 : 128. 1 June 2020

Laying out the evidence for the persistence of neurogenesis in the adult human hippocampus.
Kronenberg, G. and Klempin, F.
European Archives of Psychiatry and Clinical Neuroscience 270 (4): 497-498. June 2020

CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.
Aherrahrou, R., Kulle, A.E., Alenina, N., Werner, R., Vens-Cappell, S., Bader, M., Schunkert, H., Erdmann, J. and Aherrahrou, Z.
Scientific Reports 10 (1): 8792. 29 May 2020

Angiotensin-converting enzyme inhibitor protects against cisplatin nephrotoxicity by modulating kinin B1 receptor expression and aminopeptidase P activity in mice.
Estrela, G.R., Wasinski, F., Gregnani, M.F., Freitas-Lima, L.C., Arruda, A.C., Morais, R.L., Malheiros, D.M.A.C., Camara, N.O.S., Pesquero, J.B., Bader, M., Barros, C.C. and Araújo, R.C.
Frontiers in Molecular Biosciences 7 : 96. 20 May 2020

Short-term western diet aggravates non-alcoholic fatty liver disease (NAFLD) with portal hypertension in TGR(mREN2)27 rats.
Cremonese, C., Schierwagen, R., Uschner, F.E., Torres, S., Tyc, O., Ortiz, C., Schulz, M., Queck, A., Kristiansen, G., Bader, M., Sauerbruch, T., Weiskirchen, R., Walther, T., Trebicka, J. and Klein, S.
International Journal of Molecular Sciences 21 (9): 3308. 1 May 2020

The (pro)renin receptor: what's in a name?
Simons, M., Bader, M. and Müller, D.N.
Nature Reviews Nephrology 16 (5): 304. May 2020

Cellular importin-α3 expression dynamics in the lung regulate antiviral response pathways against influenza a virus infection.
Thiele, S., Stanelle-Bertram, S., Beck, S., Kouassi, N., Zickler, M., Müller, M., Tuku, B., Resa-Infante, P., van Riel, D., Alawi, M., Günther, T., Rother, F., Hügel, S., Reimering, S., McHardy, A., Grundhoff, A., Brune, W., Osterhaus, A., Bader, M., Hartmann, E. and Gabriel, G.
Cell Reports 31 (3): 107549. 21 April 2020

3-amino-1,2,4-triazole induces quick and strong fat loss in mice with high fat-induced metabolic syndrome.
Nunes-Souza, V., Dias-Júnior, N.M., Eleutério-Silva, M.A., Ferreira-Neves, V.P., Moura, F.A., Alenina, N., Bader, M. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2020 : 3025361. 13 April 2020

Angiotensin-(1-7) receptor Mas deficiency does not exacerbate cardiac atrophy following high-level spinal cord injury in mice.
Järve, A., Qadri, F., Todiras, M., Schmolke, S., Alenina, N. and Bader, M.
Frontiers in Physiology 11 : 203. 12 March 2020

Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
Vargas-Castillo, A., Tobon-Cornejo, S., Del Valle-Mondragon, L., Torre-Villalvazo, I., Schcolnik-Cabrera, A., Guevara-Cruz, M., Pichardo-Ontiveros, E., Fuentes-Romero, R., Bader, M., Alenina, N., Vidal-Puig, A., Hong, E., Torres, N. and Tovar, A.R.
Metabolism 103 : 154048. February 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

The activity of the STriatal-Enriched protein tyrosine Phosphatase (STEP) in neuronal cells is modulated by adenosine A(2A) receptor.
Mallozzi, C., Pepponi, R., Visentin, S., Chiodi, V., Lombroso, P.J., Bader, M., Popoli, P. and Domenici, M.R.
Journal of Neurochemistry 152 (3): 284-298. February 2020

Inter-individual and inter-strain differences in cognitive and social abilities of Dark Agouti and Wistar Han rats.
Alonso, L., Peeva, P., Ramos-Prats, A., Alenina, N., Winter, Y. and Rivalan, M.
Behavioural Brain Research 377 : 112188. 13 January 2020

Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent.
Serfozo, P., Wysocki, J., Gulua, G., Schulze, A., Ye, M., Liu, P., Jin, J., Bader, M., Myöhänen, T., García-Horsman, J.A. and Batlle, D.
Hypertension 75 (1): 173-182. January 2020

Inhibition of serotonin synthesis: a novel therapeutic paradigm.
Bader, M.
Pharmacology & Therapeutics 205 : 107423. January 2020

The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models.
Mosienko, V., Bader, M. and Alenina, N.
In: Handbook of the Behavioral Neurobiology of Serotonin. Handbook of Behavioral Neuroscience, 31 . Elsevier, London et al., 601-607. ISBN 978-0-444-64125-0 2020

2019

Oxidative stress in rheumatoid arthritis: what the future might hold regarding novel biomarkers and add-on therapies.
da Fonseca, L.J.S., Nunes-Souza, V., Goulart, M.O.F. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2019 (Special issue): 7536805. 16 December 2019

Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia.
Lima, V.M., Lino, C.A., Senger, N., de Oliveira Silva, T., Fonseca, R.I.B., Bader, M., Santos, R.A.S., Júnior, JD., Barreto-Chaves, M.L.M. and Diniz, G.P.
Molecular and Cellular Endocrinology 498 : 110576. 1 December 2019

Serotonylation: serotonin signaling and epigenetics.
Bader, M.
Frontiers in Molecular Neuroscience 12 : 288. 21 November 2019

The role of receptor MAS in microglia-driven retinal vascular development.
Foulquier, S., Caolo, V., Swennen, G., Milanova, I., Reinhold, S., Recarti, C., Alenina, N., Bader, M., Steckelings, U M., Vanmierlo, T., Post, M.J., Jones, E.A., van Oostenbrugge, R.J. and Unger, T.
Angiogenesis 22 (4): 481-189. November 2019

Increased ethanol consumption and locomotion develop upon ethanol deprivation in rats overexpressing the adenosine A(2A) receptor.
Zaniewska, M., Gawliński, D., Wyczesana, M., Nowak, E., Kula, K., Maciów-Głąb, M., Jastrzębska, J., Sadakierska-Chudy, A., Bader, M. and Fuxe, K.
Neuroscience 418 : 133-148. 15 October 2019

Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.
Binger, K.J., Neukam, M., Tattikota, S.G., Qadri, F., Puchkov, D., Willmes, D.M., Wurmsee, S., Geisberger, S., Dechend, R., Raile, K., Kurth, T., Nguyen, G., Poy, M.N., Solimena, M., Muller, D.N. and Birkenfeld, A.L.
Proceedings of the National Academy of Sciences of the United States of America 116 (40): 19983-19988. 1 October 2019

Endothelial B2-receptor overexpression as an alternative animal model for hereditary angioedema.
Lopes Veronez, C., Maghsodi, S., Todiras, M., Popova, E., Rodrigues, A.F., Qadri, F., Pesquero, J.B. and Bader, M.
Allergy 74 (10): 1998-2002. October 2019

Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.
Guimarães, P.B., da Silva, R.F., Hoff, C.C., Fernandes, L., Nakaie, C.R., Chagas, J.R., Karaoglanovic Carmona, A., Bader, M. and Pesquero, J.B.
Inflammation Research 68 (10): 845-855. October 2019

Targeted genomic integration of EGFP under tubulin beta 3 class III promoter and mEos2 under tryptophan hydroxylase 2 promoter does not produce sufficient levels of reporter gene expression.
Menzorov, A.G., Orishchenko, K.E., Fishman, V.S., Shevtsova, A.A., Mungalov, R.V., Pristyazhnyuk, I.E., Kizilova, E.A., Matveeva, N.M., Alenina, N., Bader, M., Rubtsov, N.B. and Serov, O.L.
Journal of Cellular Biochemistry 120 (10): 17208-17218. October 2019

Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis.
Sakita, J.Y., Bader, M., Santos, E.S., Garcia, S.B., Minto, S.B., Alenina, N., Brunaldi, M.O., Carvalho, M.C., Vidotto, T., Gasparotto, B., Martins, R.B., Silva, W.A., Brandão, M.L., Leite, C.A., Cunha, F.Q., Karsenty, G., Squire, J.A., Uyemura, S.A. and Kannen, V.
Journal of Pathology 249 (1): 102-113. September 2019

Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization.
Santos, N.B.D., Franco, R.D., Camarini, R., Munhoz, C.D., Eichler, R.A.S., Gewehr, M.C.F., Reckziegel, P., Llanos, R.P., Dale, C.S., da Silva, V.R.O., Borges, V.F., Lima, B.H.F., Cunha, F.Q., Visniauskas, B., Chagas, J.R., Tufik, S., Peres, F.F., Abilio, V.C., Florio, J.C., Iwai, L.K., Rioli, V., Presoto, B.C., Guimaraes, A.O., Pesquero, J.B., Bader, M., Castro, L.M. and Ferro, E.S.
Biomolecules 9 (8): 382. 19 August 2019

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
Klein, S., Kleine, C.E., Pieper, A., Granzow, M., Gautsch, S., Himmit, M., Kahrmann, K., Schierwagen, R., Uschner, F.E., Magdaleno, F., Naoum, M.E., Kristiansen, Glen, Walther, T., Bader, M., Sauerbruch, T. and Trebicka, J.
Scientific Reports 9 (1): 11598. 12 August 2019

hnRNP-K targets open chromatin in mouse embryonic stem cells in concert with multiple regulators.
Bakhmet, E.I., Nazarov, I.B., Gazizova, A.R., Vorobyeva, N.E., Kuzmin, A.A., Gordeev, M.N., Sinenko, S.A., Aksenov, N. D., Artamonova, T.O., Khodorkovskii, M.A., Alenina, N., Onichtchouk, D., Wu, G., Schöler, H.R. and Tomilin, A.N.
Stem Cells 37 (8): 1018-1029. August 2019

Targeted manipulation of brain serotonin: RNAi-mediated knockdown of tryptophan hydroxylase 2 in rats.
Matthes, S., Mosienko, V., Popova, E., Rivalan, M., Bader, M. and Alenina, N.
ACS Chemical Neuroscience 10 (7): 3207-3217. 17 July 2019

Nephropathy in hypertensive animals is linked to M2 macrophages and increased expression of the YM1/Chi3l3 protein.
Cavalcante, P.A.M., Alenina, N., Budu, A., Freitas-Lima, L.C., Alves-Silva, T., Agudelo, J.S.H., Qadri, F., Camara, N.O.S., Bader, M. and Araújo, R.C.
Mediators of Inflammation 2019 : 9086758. 10 July 2019

Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin.
Gebhardt, C., Mosienko, V., Alenina, N. and Albrecht, D.
Hippocampus 29 (7): 610-618. July 2019

The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas.
Dapper, C., Schuster, F., Stölting, I., Vogt, F., Castro e Souza, L.A., Alenina, N., Bader, M. and Raasch, W.
Naunyn-Schmiedeberg's Archives of Pharmacology 392 (7): 865-877. July 2019

Urinary renin in patients and mice with diabetic kidney disease.
Tang, J., Wysocki, J., Ye, M., Vallés, P.G., Rein, J., Shirazi, M., Bader, M., Gomez, R.A., Sequeira-Lopez, M.L.S., Afkarian, M. and Batlle, D.
Hypertension 74 (1): 83-94. July 2019

Systemic outcomes of (Pyr(1))-apelin-13 infusion at mid-late pregnancy in a rat model with preeclamptic features.
Yamaleyeva, L.M., Brosnihan, K.B., Elsangeedy, E., McGee, C., Shi, S., Caudell, D., Miller, C., Varagic, J., Bader, M., Dechend, R. and Shaltout, H.A.
Scientific Reports 9 (1): 8579. 12 June 2019

ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models.
Alenina, N. and Bader, M.
Neurochemical Research 44 (6): 1323-1329. June 2019

The renin-angiotensin system: going beyond the classical paradigms.
Santos, R.A.S., Oudit, G.Y., Verano-Braga, T., Canta, G., Steckelings, U.M. and Bader, M.
American Journal of Physiology Heart and Circulatory Physiology 316 (5): H958-H970. May 2019

Lack of brain serotonin affects feeding and differentiation of newborn cells in the adult hypothalamus.
van Lingen, M., Sidorova, M., Alenina, N. and Klempin, F.
Frontiers in Cell and Developmental Biology 7 : 65. April 2019

Serotonin deficiency increases context-dependent fear learning through modulation of hippocampal activity.
Waider, J., Popp, S., Mlinar, B., Montalbano, A., Bonfiglio, F., Aboagye, B., Thuy, E., Kern, R., Thiel, C., Araragi, N., Svirin, E., Schmitt-Böhrer, A.G., Corradetti, R., Lowry, C.A. and Lesch, K.P.
Frontiers in Neuroscience 13 : 245. April 2019

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly, L.A., Thompson, R.E., Zhao, S., Lepack, A.E., Lyu, Y., Bhanu, N.V., Zhang, B., Loh, Y.H.E., Ramakrishnan, A., Vadodaria, K.C., Heard, K.J., Erikson, G., Nakadai, T., Bastle, R.M., Lukasak, B.J., Zebroski, H., Alenina, N., Bader, M., Berton, O., Roeder, R.G., Molina, H., Gage, F.H., Shen, L., Garcia, B.A., Li, H., Muir, T.W. and Maze, I.
Nature 567 (7749): 535-539. 28 March 2019

Angiotensin-(1-7) receptor Mas in hemodynamic and thermoregulatory dysfunction after high-level spinal cord injury in mice: a pilot study.
Järve, A., Todiras, M., Kny, M., Fischer, F.I., Kraemer, J.F., Wessel, N., Plehm, R., Fielitz, J., Alenina, N. and Bader, M.
Frontiers in Physiology 9 : 1930. January 2019

Distinct roles of angiotensin receptors in autonomic dysreflexia following high-level spinal cord injury in mice.
Järve, A., Todiras, M., Lian, X, Filippelli-Silva, R., Qadri, F., Martin, R.P., Gollasch, M. and Bader, M.
Experimental Neurology 311 : 173-181. January 2019

Genetic deletion of the alamandine receptor MrgD leads to dilated cardiomyopathy in mice.
Oliveira, A.C., Melo, M.B., Motta-Santos, D., Peluso, A.A., Souza-Neto, F., da Silva, R.F., Almeida, J.F.Q., Canta, G., Reis, A.M., Goncalves, G., Cerri, G.G., Coutinho, D., de Jesus, I.C.G., Guatimosim, S., Linhares, N.D., Alenina, N., Bader, M., Campagnole-Santos, M.J. and Santos, R.A.S.
American Journal of Physiology Heart and Circulatory Physiology 316 (1): H123-H133. January 2019

Genetic models.
Alenina, N. and Bader, M.
In: Angiotensin-(1-7) : a comprehensive review. Springer, Cham, 35-51. ISBN 978-3-030-22695-4 2019

2018

Importin α5 regulates anxiety through MeCP2 and sphingosine kinase 1.
Panayotis, N., Sheinin, A., Dagan, S.Y., Tsoory, M.M., Rother, F., Vadhvani, M., Meshcheriakova, A., Koley, S., Marvaldi, L., Song, D.A., Reuveny, E., Eickholt, B.J., Hartmann, E., Bader, M., Michaelevski, I. and Fainzilber, M.
Cell Reports 25 (11): 3169-3179. 11 December 2018

Transfer of synthetic human chromosome into human induced pluripotent stem cells for biomedical applications.
Sinenko, S.A., Skvortsova, E.V., Liskovykh, M.A., Ponomartsev, S.V., Kuzmin, A.A., Khudiakov, A.A., Malashicheva, A.B., Alenina, N., Larionov, V., Kouprina, N. and Tomilin, A.N.
Cells 7 (12): 261. 8 December 2018

Exon skipping in a Dysf-missense mutant mouse model.
Malcher, J., Heidt, L., Goyenvalle, A., Escobar, H., Marg, A., Beley, C., Benchaouir, R., Bader, M., Spuler, S., García, L. and Schöwel, V.
Molecular Therapy - Nucleic Acids 13 : 198-207. 7 December 2018

Apelinergic system in the kidney: implications for diabetic kidney disease.
Müller, T., Kalea, A.Z., Marquez, A., Hsieh, I., Haque, S., Ye, M., Wysocki, J., Bader, M. and Batlle, D.
Physiological Reports 6 (23): e13939. December 2018

Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.
Kronenberg, G., Petermann, M., Dormann, C., Bader, M., Gass, P., Hellweg, R. and Klempin, F.
European Archives of Psychiatry and Clinical Neuroscience 268 (8): 861-864. December 2018

Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801.
Hámor, P.U., Šírová, J., Páleníček, T., Zaniewska, M., Bubeníková-Valešová, V. and Schwendt, M.
Pharmacology Biochemistry and Behavior 175 : 89-100. December 2018

Chronic overexpression of bradykinin in kidney causes polyuria and cardiac hypertrophy.
Barros, C.C., Schadock, I., Sihn, G., Rother, F., Xu, P., Popova, E., Lapidus, I., Plehm, R., Heuser, A., Todiras, M., Bachmann, S., Alenina, N., Araujo, R.C., Pesquero, J.B. and Bader, M.
Frontiers in Medicine 5 : 338. December 2018

TRPM8 activation via 3-iodothyronamine blunts VEGF-induced transactivation of TRPV1 in human uveal melanoma cells.
Walcher, L., Budde, C., Böhm, A., Reinach, P.S., Dhandapani, P., Ljubojevic, N., Schweiger, M.W., von der Waydbrink, H., Reimers, I., Köhrle, J. and Mergler, S.
Frontiers in Pharmacology 9 : 1234. 13 November 2018

Bradykinin B2 receptor is essential to running-induced cell proliferation in the adult mouse hippocampus.
Wasinski, F., Oliveira Batista, R., Bader, M., Araujo, R.C. and Klempin, F.
Brain Structure & Function 223 (8): 3901-3907. November 2018

The Meaning of Mas.
Bader, M., Alenina, N., Young, D., Santos, R.A.S. and Touyz, R.M.
Hypertension 72 (5): 1072-1075. November 2018

The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus.
Micakovic, T., Papagiannarou, S., Clark, E., Kuzay, Y., Abramovic, K., Peters, J., Sticht, C., Volk, N., Fleming, T., Nawroth, P., Hammes, H.P., Alenina, N., Gröne, H.J. and Hoffmann, S.C.
Kidney International 94 (5): 937-950. November 2018

TPH2 deficiency influences neuroplastic mechanisms and alters the response to an acute stress in a sex specific manner.
Brivio, P., Sbrini, G., Peeva, P., Todiras, M., Bader, M., Alenina, N. and Calabrese, F.
Frontiers in Molecular Neuroscience 11 : 389. 30 October 2018

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.
Klempin, F., Mosienko, V., Matthes, S., Villela, D.C., Todiras, M., Penninger, J.M., Bader, M., Santos, R.A.S. and Alenina, N.
Cellular and Molecular Life Sciences 75 (19): 3625-3634. October 2018

Genetic deletion of the Angiotensin-(1-7) receptor Mas leads a reduced ovulatory rate.
Honorato-Sampaio, K., Ferreira Andrade, R., Bader, M., de Souza Martins, A., Souza Santos, R.A. and Reis, A.M.
Peptides 107 : 83-88. September 2018

Neuronal adenosine A(2A) receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington's disease.
Domenici, M.R., Chiodi, V., Averna, M., Armida, M., Pèzzola, A., Pepponi, R., Ferrante, A., Bader, M., Fuxe, K. and Popoli, P.
Purinergic Signalling 14 (3): 235-243. September 2018

Renin-angiotensin system in aortic aneurysm: still adding puzzle stones to an anything but complete picture.
Steckelings, U.M. and Bader, M.
Hypertension 72 (3): 579-581. September 2018

Role of 3-acetyl-11-keto-beta-boswellic acid in counteracting LPS-induced neuroinflammation via modulation of miRNA-155.
Sayed, A.S., Gomaa, I.E.O., Bader, M. and El Sayed, N.S.E.D.
Molecular Neurobiology 55 (7): 5798-5808. July 2018

ATP6AP2 over-expression causes morphological alterations in the hippocampus and in hippocampus-related behaviour.
Bracke, A., Schäfer, S., von Bohlen und Halbach, V., Klempin, F., Bente, K., Bracke, K., Staar, D., van den Brandt, J., Harzsch, S., Bader, M., Wenzel, U.O., Peters, J. and von Bohlen und Halbach, O.
Brain Structure & Function 223 (5): 2287-2302. June 2018

Alamandine acts via MrgD to induce AMPK/NO activation against Ang II hypertrophy in cardiomyocytes.
de Jesus, I.C.G., Scalzo, S., Alves, F., Marques, K., Rocha-Resende, C., Bader, M., Santos, R.A.S. and Guatimosim, S.
American Journal of Physiology Cell Physiology 314 (6): C702-C711. June 2018

Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice.
da Silva, I.B., Gomes, D.A., Alenina, N., Bader, M., dos Santos, R.A. and Barreto-Chaves, M.L.M.
Heart and Vessels 33 (6): 671-681. June 2018

Cystathionine γ-lyase-produced hydrogen sulfide controls endothelial NO bioavailability and blood pressure.
Szijártó, I.A., Markó, L., Filipovic, M.R., Miljkovic, J.L., Tabeling, C., Tsvetkov, D., Wang, N., Rabelo, L.A., Witzenrath, M., Diedrich, A., Tank, J., Akahoshi, N., Kamata, S., Ishii, I. and Gollasch, M.
Hypertension 71 (6): 1210-1217. June 2018

Development of obesity can be prevented in rats by chronic icv infusions of AngII but less by Ang(1-7).
Winkler, M., Bader, M., Schuster, F., Stölting, I., Binder, S. and Raasch, W.
Pflugers Archiv 470 (6): 867-881. June 2018

Mast cells and serotonin synthesis modulate Chagas disease in the colon: clinical and experimental evidence.
Kannen, V., Sakita, J.Y., Carneiro, Z.A., Bader, M., Alenina, N., Teixeira, R.R., de Oliveira, E.C., Brunaldi, M.O., Gasparotto, B., Sartori, D.C., Fernandes, C.R., Silva, J.S., Andrade, M.V., Silva, W.A., Uyemura, S.A. and Garcia, S.B.
Digestive Diseases and Sciences 63 (6): 1473-1484. June 2018

Peripheral serotonin synthesis as a new drug target.
Matthes, S. and Bader, M.
Trends in Pharmacological Sciences 39 (6): 560-572. June 2018

Continuous blood glucose monitoring reveals enormous circadian variations in pregnant diabetic rats.
Golic, M., Kräker, K., Fischer, C., Alenina, N., Haase, N., Herse, F., Schütte, T., Henrich, W., Müller, D.N., Busjahn, A., Bader, M. and Dechend, R.
Frontiers in Endocrinology 9 : 271. 29 May 2018

Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix.
Reimann, H.M., Todiras, M., Hodge, Russ, Huelnhagen, T., Millward, J.M., Turner, R., Seeliger, E., Bader, M., Pohlmann, A. and Niendorf, T.
NeuroImage 172 : 562-574. 15 May 2018

Diabetes mellitus in pregnancy leads to growth restriction and epigenetic modification of the Srebf2 gene in rat fetuses.
Golic, M., Stojanovska, V., Bendix, I., Wehner, A., Herse, F., Haase, N., Kräker, K., Fischer, C., Alenina, N., Bader, M., Schütte, T., Schuchardt, M., van der Giet, M., Henrich, W., Muller, D.N., Felderhoff-Müser, U., Scherjon, S., Plösch, T. and Dechend, R.
Hypertension 71 (5): 911-920. May 2018

Identification of protein phosphatase involvement in the AT(2)-receptor induced activation of endothelial nitric oxide synthase.
Peluso, A.A., Bertelsen, J.B., Andersen, K., Mortensen, T.P., Hansen, P.B., Sumners, C., Bader, M., Santos, R.A. and Steckelings, U.M.
Clinical Science 132 (7): 777-790. 6 April 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Sowa, A.S., Martin, E., Martins, I.M., Schmidt, J., Depping, R., Weber, J.J., Rother, F., Hartmann, E., Bader, M., Riess, O., Tricoire, H. and Schmidt, T.
Proceedings of the National Academy of Sciences of the United States of America 115 (11): E2624-E2633. 13 March 2018

Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same.
Max-Delbrück-Centrum für Molekulare Medizin.
201615552556. 22 February 2018

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.
Döhner, K., Ramos-Nascimento, A., Bialy, D., Anderson, F., Hickford-Martinez, A., Rother, F., Koithan, T., Rudolph, K., Buch, A., Prank, U., Binz, A., Hügel, S., Lebbink, R.J., Hoeben, R.C., Hartmann, E., Bader, M., Bauerfeind, R. and Sodeik, B.
PLoS Pathogens 14 (1): e1006823. 5 January 2018

Kinin B1 receptors as a therapeutic target for inflammation.
Qadri, F. and Bader, M.
Expert Opinion on Therapeutic Targets 22 (1): 31-44. January 2018

The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7).
Santos, R.A.S., Sampaio, W.O., Alzamora, A.C., Motta-Santos, D., Alenina, N., Bader, M. and Campagnole-Santos, M.J.
Physiological Reviews 98 (1): 505-553. January 2018

2017

Renin-angiotensin system in diabetes.
Rein, J. and Bader, M.
Protein and Peptide Letters 24 (9): 833-840. 17 November 2017

Serotonin regulates prostate growth through androgen receptor modulation.
Carvalho-Dias, E., Miranda, A., Martinho, O., Mota, P., Costa, A., Nogueira-Silva, C., Moura, R.S., Alenina, N., Bader, M., Autorino, R., Lima, E. and Correia-Pinto, J.
Scientific Reports 7 (1): 15428. 13 November 2017

Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium.
Levy, R.F., Serra, A.J., Antonio, E.L., dos Santos, L., Bocalini, D.S., Pesquero, J.B., Bader, M., Merino, V.F., de Oliveira, H.A., de Arruda Veiga, E.C., Silva, J.A. and Tucci, P.J.F.
Physiological Research 66 (6): 925-932. 22 September 2017

Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein.
Dartora, D.R., Irigoyen, M.C., Casali, K.R., Moraes-Silva, I.C., Bertagnolli, M., Bader, M. and Santos, R.
Canadian Journal of Physiology and Pharmacology 95 (9): 993-998. September 2017

Ly6C(high) monocytes oscillate in the heart during homeostasis and after myocardial infarction.
Schloss, M.J., Hilby, M., Nitz, K., Guillamat Prats, R., Ferraro, B., Leoni, G., Soehnlein, O., Kessler, T., He, W., Luckow, B., Horckmans, M., Weber, C., Duchene, J. and Steffens, S.
Arteriosclerosis Thrombosis and Vascular Biology 37 (9): 1640-1645. September 2017

Validation of commercial Mas receptor antibodies for utilization in Western Blotting, immunofluorescence and immunohistochemistry studies.
Burghi, V., Fernández, N.C., Gándola, Y.B., Piazza, V.G., Quiroga, D.T., Guilhen Mario, E., Felix Braga, J., Bader, M., Santos, R.A.S., Dominici, F.P. and Munoz, M.C.
PLoS ONE 12 (8): e0183278. 16 August 2017

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J., Novitzky-Basso, I., Thiriot, A., Casanova-Acebes, M., Bianchini, M., Etheridge, S.L., Hub, E., Nitz, K., Artinger, K., Eller, K., Caamano, J., Ruelicke, T., Moss, P., Megens, R.T.A., von Andrian, U.H., Hidalgo, A., Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

Of mice and renin.
Bader, M.
Hypertension 70 (1): 35-37. July 2017

Brain renin-angiotensin system: does it exist?
van Thiel, B.S., Góes Martini, A., Te Riet, L., Severs, D., Uijl, E., Garrelds, I.M., Leijten, F.P.J., van der Pluijm, I., Essers, J., Qadri, F., Alenina, N., Bader, M., Paulis, L., Rajkovicova, R., Domenig, O., Poglitsch, M. and Danser, A.H.J.
Hypertension 69 (6): 1136-1144. June 2017

Evidence for heterodimerization and functional interaction of the angiotensin Type 2 receptor and the receptor MAS.
Leonhardt, J., Villela, D.C., Teichmann, A., Münter, L.-M., Mayer, M.C., Mardahl, M., Kirsch, S., Namsolleck, P., Lucht, K., Benz, V., Alenina, N., Daniell, N., Horiuchi, M., Iwai, M., Multhaup, G., Schülein, R., Bader, M., Santos, R.A., Unger, T. and Steckelings, U.M.
Hypertension 69 (6): 1128-1135. June 2017

Rodents and humans are able to detect the odour of L-Lactate.
Mosienko, V., Chang, A.J., Alenina, N., Teschemacher, A.G. and Kasparov, S.
PLoS ONE 12 (5): e0178478. 25 May 2017

Comeback of the rat in biomedical research.
Homberg, J.R., Woehr, M. and Alenina, N.
ACS Chemical Neuroscience 8 (5): 900-903. 17 May 2017

Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.
Maier, C., Schadock, I., Haber, P.K., Wysocki, J., Ye, M., Kanwar, Y., Flask, C.A., Yu, X., Hoit, B.D., Adams, G.N., Schmaier, A.H., Bader, M. and Batlle, D.
Journal of Molecular Medicine 95 (5): 473-486. May 2017

MATE-1 modulation by kinin B1 receptor enhances cisplatin efflux from renal cells.
Estrela, G.R., Wasinski, F., Felizardo, R.J.F., Souza, L.L., Camara, N.O.S., Bader, M. and Araujo, R.C.
Molecular and Cellular Biochemistry 428 (1): 101-108. April 2017

Elastase-2, a tissue alternative pathway for angiotensin II generation, plays a role in circulatory sympathovagal balance in mice.
Becari, C., Durand, M.T., Guimaraes, A.O., Lataro, R.M., Prado, C.M., de Oliveira, M., Candido, S.C.O., Pais, P., Ribeiro, M.S., Bader, M., Pesquero, J.B., Salgado, M.C.O. and Salgado, H.C.
Frontiers in Physiology 8 : 170. 23 March 2017

Physical exercise on inflammatory markers in type 2 diabetes patients: a systematic review of randomized controlled trials.
Melo, L.C., Dativo-Medeiros, J., Menezes-Silva, C.E., Barbosa, F.T., de Sousa-Rodrigues, C.. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2017 (2017): 8523728. 19 March 2017

Calcineurin inhibitor cyclosporine a activates renal Na-K-Cl cotransporters via local and systemic mechanisms.
Blankenstein, K.I., Borschewski, A., Labes, R., Paliege, A., Boldt, C., McCormick, J.A., Ellison, D.H., Bader, M., Bachmann, S. and Mutig, K.
American Journal of Physiology Renal Physiology 312 (3): F489-F501. 2 March 2017

Caloric restriction is more efficient than physical exercise to protect from cisplatin nephrotoxicity via PPAR-alpha activation.
Estrela, G.R., Wasinski, F., Batista, R.O., Hiyane, M.I., Felizardo, R.J.F., Cunha, F., de Almeida, D.C., Malheiros, D.M.A.C., Camara, N.O.S., Barros, C.C., Bader, M. and Araujo, R.C.
Frontiers in Physiology 8 : 116. 2 March 2017

High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism.
Morais, R.L., Hilzendeger, A.M., Visniauskas, B., Todiras, M., Alenina, N., Mori, M.A., Araújo, R.C., Nakaie, C.R., Chagas, J.R., Carmona, A.., Bader, M. and Pesquero, J.B.
American Journal of Physiology Heart and Circulatory Physiology 312 (3): H437-H445. 1 March 2017

Redox homeostasis: unlocking the bottleneck in glia-to-neuron conversion.
Klempin, F., Gertz, K. and Kronenberg, G.
Stem Cell Investigation 4 : 7. 9 February 2017

Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
Järve, A., Mühlstedt, S., Qadri, F., Nickl, B., Schulz, H., Hübner, N., Özcelik, C. and Bader, M.
FASEB Journal 31 (2): 556-568. February 2017

Investigating the link between MCP-1 A-2518G, RANTES G-403A, CX3CR1 V249I and MTHFR C677T gene polymorphisms and the risk of acute myocardial infarction among Egyptians.
Hashad, I.M., Abdel Rahman, M.F., Alenina, N., Bader, M. and Gad, M.Z.
Meta Gene 11 : 181-188. February 2017

Glucagon-producing cells are increased in Mas-deficient mice.
Felix Braga, J., Ravizzoni Dartora, D., Alenina, N., Bader, M. and Santos, R.A.S.
Endocrine Connections 6 (1): 27-32. January 2017

The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown.
Reichhart, N., Crespo-Garcia, S., Haase, N., Golic, M., Skosyrski, S., Rübsam, A., Herrspiegel, C., Kociok, N., Alenina, N., Bader, M., Dechend, R., Strauss, O. and Joussen, A.M.
Diabetologia 60 (1): 202-211. January 2017

Evaluation of endothelial dysfunction in vivo.
Todiras, M., Alenina, N. and Bader, M.
Methods in Molecular Biology 1527 : 355-367. 2017

2016

Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders.
Hadar, R., Edemann-Callesen, H., Reinel, C., Wieske, F., Voget, M., Popova, E., Sohr, R., Avchalumov, Y., Priller, J., van Riesen, C., Puls, I., Bader, M. and Winter, C.
Scientific Reports 6 : 39145. 15 December 2016

Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice.
Magalhaes, G.S., Rodrigues-Machado, M.G., Motta-Santos, D., Alenina, N., Bader, M., Santos, R.A.S., Barcelos, L.S. and Campagnole-Santos, M.J.
American Journal of Physiology Lung Cellular and Molecular Physiology 311 (6): L1141-L1148. 12 December 2016

Role of the receptor Mas in macrophage-mediated inflammation in vivo.
Hammer, A., Yang, G., Friedrich, J., Kovacs, A., Lee, D.H., Grave, K., Jörg, S., Alenina, N., Grosch, J., Winkler, J., Gold, R., Bader, M., Manzel, A., Rump, L.C., Müller, D.N., Linker, R.A. and Stegbauer, J.
Proceedings of the National Academy of Sciences of the United States of America 113 (49): 14109-14114. 6 December 2016

C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit, J., Shanks, J., Li, D., Hao, G., Athwal, A., Langenickel, T.H., Wright, H., da Costa Goncalves, A.C., Monti, J., Plehm, R., Popova, E., Qadri, F., Lapidus, I., Ryan, B., Özcelik, C., Paterson, D.J., Bader, M. and Herring, N.
Cardiovascular Research 112 (3): 637-644. December 2016

Karyopherin alpha 1 regulates satellite cell proliferation and survival by modulating nuclear import.
Choo, H.J., Cutler, A., Rother, F., Bader, M. and Pavlath, G.K.
Stem Cells 34 (11): 2784-2797. November 2016

Increased adult neurogenesis in mice with a permanent overexpression of the postsynaptic 5-HT1A receptor.
Noto, B., Klempin, F., Alenina, N., Bader, M., Fink, H. and Sander, S.E.
Neuroscience Letters 633 : 246-251. 28 October 2016

Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney.
Domenig, O., Manzel, A., Grobe, N., Königshausen, E., Kaltenecker, C.C., Kovarik, J.J., Stegbauer, J., Gurley, S.B., van Oyen, D., Antlanger, M., Bader, M., Motta-Santos, D., Santos, R.A., Elased, K.M., Säemann, M.D., Linker, R.A. and Poglitsch, M.
Scientific Reports 6 : 33678. 21 September 2016

Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same.
Max-Delbrück-Centrum für Molekulare Medizin.
WO/2016/135199. 1 September 2016

Cardiomyocyte-derived CXCL12 is not involved in cardiogenesis but plays a crucial role in myocardial infarction.
Mühlstedt, S., Ghadge, S.K., Duchene, J., Qadri, F., Järve, A., Vilianovich, L., Popova, E., Pohlmann, A., Niendorf, T., Boyé, P., Özcelik, C. and Bader, M.
Journal of Molecular Medicine 94 (9): 1005-1014. September 2016

Maternal forced swimming reduces cell proliferation in the postnatal dentate gyrus of mouse offspring.
Wasinski, F., Estrela, G.R., Arakaki, A.M., Bader, M., Alenina, N., Klempin, F. and Araújo, R.C.
Frontiers in Neuroscience 10 : 402. 29 August 2016

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Batalha, V.L., Ferreira, D.G., Coelho, J.E., Valadas, J.S., Gomes, R., Temido-Ferreira, M., Shmidt, T., Baqi, Y., Buée, L., Müller, C.E., Hamdane, M., Outeiro, T.F., Bader, M., Meijsing, S.H., Sadri-Vakili, G., Blum, D. and Lopes, L.V.
Scientific Reports 6 : 31493. 11 August 2016

Demonstration of the functional impact of vasopressin signaling in the thick ascending limb by a targeted transgenic rat approach.
Mutig, K., Borowski, T., Boldt, C., Borschewski, A., Paliege, A., Popova, E., Bader, M. and Bachmann, S.
American Journal of Physiology Renal Physiology 311 (2): F411-F423. 1 August 2016

The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment.
Schloss, M.J., Horckmans, M., Nitz, K., Duchene, J., Drechsler, M., Bidzhekov, K., Scheiermann, C., Weber, C., Soehnlein, O. and Steffens, S.
EMBO Molecular Medicine 8 (8): 937-948. 1 August 2016

Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise.
Motta-Santos, D., Dos Santos, R.A.S., Oliveira, M., Qadri, F., Poglitsch, M., Mosienko, V., Kappes Becker, L., Campagnole-Santos, M.J., Penninger, J.M., Alenina, N. and Bader, M.
Hypertension Research 39 (7): 506-512. July 2016

Kinin receptors in skin wound healing.
da Soley, B., Morais, R.L.T., Pesquero, J.B., Bader, M., Otuki, M.F. and Cabrini, D.A.
Journal of Dermatological Science 82 (2): 95-105. May 2016

The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced rat obesity.
Winkler, M., Schuchard, J., Stölting, I., Vogt, F.M., Barkhausen, J., Thorns, C., Bader, M. and Raasch, W.
British Journal of Pharmacology 173 (10): 1602-1617. May 2016

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene.
Ferrario, C.M., VonCannon, J.L., Jiao, Y., Ahmad, S., Bader, M., Dell'Italia, L.J., Groban, L. and Varagic, J.
American Journal of Physiology Heart and Circulatory Physiology 310 (8): H995-H1002. 15 April 2016

Increased vascular sympathetic modulation in mice with Mas receptor deficiency.
Rabello Casali, K., Ravizzoni Dartora, D., Moura, M., Bertagnolli, M., Bader, M., Haibara, A., Alenina, N., Irigoyen, M.C. and Santos, R.A.
Journal of the Renin-Angiotensin-Aldosterone System 17 (2): 1470320316643643. 13 April 2016

Genetic deletion of ACE2 induces vascular dysfunction in C57BL/6 mice: role of nitric oxide imbalance and oxidative stress.
Rabelo, L.A., Todiras, M., Nunes-Souza, V., Qadri, F., Szijártó, I.A., Gollasch, M., Penninger, J.M., Bader, M., Santos, R.A. and Alenina, N.
PLoS ONE 11 (4): e0150255. 12 April 2016

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas.
Morales, M.G., Abrigo, J., Acuna, M.J., Santos, R.A., Bader, M., Brandan, E., Simonetta, F., Olguin, H., Cabrera, D. and Cabello-Verrugio, C.
Disease Models & Mechanisms 9 (4): 441-449. 1 April 2016

Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.
Kronenberg, G., Mosienko, V., Gertz, K., Alenina, N., Hellweg, R. and Klempin, F.
European Archives of Psychiatry and Clinical Neuroscience 266 (3): 281-284. April 2016

Identification of a novel agonist-like autoantibody in preeclamptic patients.
Velloso, E.P., Pimentel, R.L., Braga, J.F., Cabral, A.C.V., Reis, Z.S.N., Bader, M., Santos, R.A.S. and Wallukat, G.
American Journal of Hypertension 29 (3): 405-412. March 2016

Locus coeruleus dysfunction in transgenic rats with low brain angiotensinogen.
Ogier, M., Bricca, G., Bader, M. and Bezin, L.
CNS Neuroscience & Therapeutics 22 (3): 230-237. March 2016

Striatal adenosine-cannabinoid receptor interactions in rats overexpressing adenosine A2A receptors.
Chiodi, V., Ferrante, A., Ferraro, L., Potenza, R.L., Armida, M., Beggiato, S., Pezzola, A., Bader, M., Fuxe, K., Popoli, P. and Domenici, M.R.
Journal of Neurochemistry 136 (5): 907-917. March 2016

Normothermic mouse functional MRI of acute focal thermostimulation for probing nociception.
Reimann, H.M., Hentschel, J., Marek, J., Huelnhagen, T., Todiras, M., Kox, S., Waiczies, S., Hodge, R., Bader, M., Pohlmann, A. and Niendorf, T.
Scientific Reports 6 : 17230. 29 January 2016

Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors.
Qadri, F., Rimmele, F., Mallis, L., Häuser, W., Dendorfer, A., Jöhren, O., Dominiak, P., Leeb-Lundberg, L.M.F. and Bader, M.
Biological Chemistry 397 (2): 97-109. January 2016

The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
Silva, C.R., Oliveira, S.M., Hoffmeister, C., Funck, V., Guerra, G.P., Trevisan, G., Tonello, R., Rossato, M.F., Pesquero, J.B., Bader, M., Oliveira, M.S., McDougall, J.J. and Ferreira, J.
Annals of the Rheumatic Diseases 75 (1): 260-268. January 2016

Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL/6 mice: Improvement in glycemic and lipid profile after antioxidant therapy.
Nunes-Souza, V., Cesar-Gomes, C.J., da Fonseca, L.J.S., da Silva Guedes, G., Smaniotto, S. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2016 : 1987960. 2016

CD36/sirtuin 1 axis impairment contributes to hepatic steatosis in ACE2-deficient mice.
Nunes-Souza, V., Alenina, N., Qadri, F., Penninger, J.M., Santos, R.A.S., Bader, M. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2016 : 6487509. 2016

Nikolai V. Timoféeff-Ressovsky in Berlin-Buch (1925–1945).
Rajewsky, M., Lafuente, D. and Bader, M.
In: Genetics, Evolution and Radiation. Springer, 13-28. ISBN 978-3-319-48837-0 2016

2015

Effect of angiotensin(1-7) on heart function in an experimental rat model of obesity.
Blanke, K., Schlegel, F., Raasch, W., Bader, M., Dähnert, I., Dhein, S. and Salameh, A.
Frontiers in Physiology 6 : 392. 21 December 2015

Exercise during pregnancy protects adult mouse offspring from diet-induced obesity.
Wasinski, F., Bacurau, R.F.P., Estrela, G.R., Klempin, F., Arakaki, A.M., Batista, R.O., Mafra, F.F.P., do Nascimento, L.F.R., Hiyane, M.I., Velloso, L.A., Camara, N.O.S. and Araujo, R.C.
Nutrition & Metabolism 12 : 56. 18 December 2015

Mas receptor deficiency exacerbates lipopolysaccharide-induced cerebral and systemic inflammation in mice.
Oliveira-Lima, O.C., Pinto, M.C.X., Duchene, J., Qadri, F., Souza, L.L., Alenina, N., Bader, M., Santos, R.A.S. and Carvalho-Tavares, J.
Immunobiology 220 (12): 1311-1321. December 2015

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states.
Madalli, S., Beyrau, M., Whiteford, J., Duchene, J., Singh Nandhra, I., Patel, N.S.A., Motwani, M.P., Gilroy, D.W., Thiemermann, C., Nourshargh, S. and Scotland, R.S.
Biology of Sex Differences 6 : 27. 26 November 2015

Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy.
Pulgar, V.M., Yamaleyeva, L.M., Varagic, J., McGee, C., Bader, M., Dechend, R. and Brosnihan, K.B.
American Journal of Physiology Endocrinology and Metabolism 309 (9): E811-E817. 1 November 2015

Importin-α7 is involved in the formation of Ebola virus inclusion bodies but is not essential for pathogenicity in mice.
Gabriel, G., Feldmann, F., Reimer, R., Thiele, S., Fischer, M., Hartmann, E., Bader, M., Ebihara, H., Hoenen, T. and Feldmann, H.
Journal of Infectious Diseases 212 (Suppl 2): S316-S321. 1 October 2015

Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene.
Alenina, N., Böhme, I., Bader, M. and Walther, T.
Gene 568 (2): 155-164. 1 September 2015

Receptors, G proteins, and integration of calcium signalling.
Gudermann, T. and Bader, M.
Journal of Molecular Medicine 93 (9): 937-940. September 2015

Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice.
Morais, R.L., Silva, E.D., Sales, V.M., Filippelli-Silva, R., Mori, M.A., Bader, M. and Pesquero, J.B.
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 8 : 399-407. 26 August 2015

Deletion of kinin B2 receptor alters muscle metabolism and exercise performance.
Reis, F.C.G., Haro, A.S., Bacurau, A.V.N., Hirabara, S.M., Wasinski, F., Ormanji, M.S., Moreira, J.B.N., Kiyomoto, B.H., Bertoncini, C.R.A., Brum, P.C., Curi, R., Bader, M., Bacurau, R.F.P., Pesquero, J.B. and Araújo, R.C.
PLoS ONE 10 (8): e0134844. 24 August 2015

Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats.
Zaniewska, M., Alenina, N., Wydra, K., Fröhler, S., Kuśmider, M., McCreary, A.C., Chen, W., Bader, M. and Filip, M.
Journal of Neurochemistry 134 (4): 704-716. August 2015

Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway.
Schuchard, J., Winkler, M., Stölting, I., Schuster, F., Vogt, F.M., Barkhausen, J., Thorns, C., Santos, R.A., Bader, M. and Raasch, W.
British Journal of Pharmacology 172 (15): 3764-3778. August 2015

Beyond gene inactivation: evolution of tools for analysis of serotonergic circuitry.
Hainer, C., Mosienko, V., Koutsikou, S., Crook, J.J., Gloss, B., Kasparov, S., Lumb, B.M. and Alenina, N.
ACS Chemical Neuroscience 6 (7): 1116-1129. 15 July 2015

Increased aortic intimal proliferation due to MasR deletion in vitro.
Alsaadon, H., Kruzliak, P., Smardencas, A., Hayes, A., Bader, M., Angus, P., Herath, C. and Zulli, A.
International Journal of Experimental Pathology 96 (3): 183-187. June 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47 (6): 647-653. June 2015

Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells.
Fishman, V.S., Shnayder, T.A., Orishchenko, K.E., Bader, M., Alenina, N. and Serov, O.L.
Cell Cycle 14 (8): 1188-1196. 15 April 2015

Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice.
Liskovykh, M., Ponomartsev, S., Popova, E., Bader, M., Kouprina, N., Larionov, V., Alenina, N. and Tomilin, A.
Cell Cycle 14 (8): 1268-1273. 15 April 2015

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
Walentin, K., Hinze, C., Werth, M., Haase, N., Varma, S., Morell, R., Aue, A., Pötschke, E., Warburton, D., Qiu, A., Barasch, J., Purfürst, B., Dieterich, C., Popova, E., Bader, M., Dechend, R., Staff, A.C., Yurtdas, Z.Y., Kilic, E. and Schmidt-Ott, K.M.
Development 142 (6): 1125-1136. 15 March 2015

Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin.
Mosienko, V., Beis, D., Alenina, N. and Woehr, M.
Molecular Autism 6 : 13. 8 March 2015

Brain serotonin deficiency leads to social communication deficits in mice.
Beis, D., Holzwarth, K., Flinders, M., Mosienko, V., Bader, M., Wöhr, M. and Alenina, N.
Biology Letters 11 (3): 20150057. March 2015

Sex dependent differences in renal angiotensinogen as an early marker of diabetic nephropathy.
de Alencar Franco Costa, D., Todiras, M., Campos, L.A., Cipolla-Neto, J., Bader, M. and Baltatu, O.C.
Acta Physiologica 213 (3): 740-746. March 2015

Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies.
Cofre, C., Acuna, M.J., Contreras, O., Morales, M.G., Riquelme, C., Bader, M., Santos, R., Cabello-Verrugio, C. and Brandan, E.
BioFactors 41 (2): 111-120. March 2015

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison.
Villela, D., Leonhardt, J., Patel, N., Joseph, J., Kirsch, S., Hallberg, A., Unger, T., Bader, M., Santos, R.A., Sumners, C. and Steckelings, U.M.
Clinical Science 128 (4): 227-234. 1 February 2015

Vitamin D depletion aggravates hypertension and target-organ damage.
Andersen, L.B., Przybyl, L., Haase, N., von Versen-Höynck, F., Qadri, F., Jørgensen, J.S., Sorensen, G.L., Fruekilde, P., Poglitsch, M., Szijártó, I., Gollasch, M., Peters, J., Muller, D.N., Christesen, H.T. and Dechend, R.
Journal of the American Heart Association 4 (2): e001417. February 2015

Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis.
Mosienko, V., Beis, D., Pasqualetti, M., Waider, J., Matthes, S., Qadri, F., Bader, M. and Alenina, N.
Behavioural Brain Research 277 (SI): 78-88. 15 January 2015

The role of serotonin in adult hippocampal neurogenesis.
Alenina, N. and Klempin, F.
Behavioural Brain Research 277 : 49-57. 15 January 2015

Angiotensin-(1-7) and Mas: a brief history.
Alenina, N. and dos Santos, R.A.
In: The Protective Arm of the Renin Angiotensin System (RAS). Elsevier, Amsterdam, NL, 155-159. ISBN 9780128013649 2015

Animal models with a genetic alteration of the ACE2/Ang-(1-7)/Mas axis.
Rabelo, L.A., Nunes-Souza, V. and Bader, M.
In: The Protective Arm of the Renin Angiotensin System (RAS). Elsevier, Amsterdam, NL, 161-168. ISBN 9780128013649 2015

Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis.
Rabelo, L.A., Ferreira, F.O., Nunes-Souza, V., da Fonseca, L.J.S. and Goulart, M.O.F.
Oxidative Medicine and Cellular Longevity 2015 : 924860. 2015

2014

Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.
Dai, R., Rossello, R., Chen, C.C., Kessler, J., Davison, I., Hochgeschwender, U. and Jarvis, E.D.
Stem Cells International 2014 : 182737. 9 December 2014

Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats.
Barmashenko, G., Buttgereit, J., Herring, N., Bader, M., Oezcelik, C., Manahan-Vaughan, D. and Braunewell, K.H.
Frontiers in Molecular Neuroscience 7 : 95. 1 December 2014

Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.
Tank, J., da Costa-Goncalves, A.C., Kamer, I., Qadri, F., Ubhi, K., Rockenstein, E., Diedrich, A., Masliah, E., Gross, V. and Jordan, J.
Physiological Reports 2 (11): e12209. 26 November 2014

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.
Cui, Y., Niziolek, P.J., MacDonald, B.T., Alenina, N., Matthes, S., Jacobsen, C.M., Conlon, R.A., Brommage, R., Powell, D.R., He, X., Bader, M., Williams, B.O., Warman, M.L. and Robling, A.G.
Nature Medicine 20 (11): 1229-1230. 6 November 2014

Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.
Markó, L., Henke, N., Park, J.K., Spallek, B., Qadri, F., Balogh, A., Apel, I.J., Oravecz-Wilson, K.I., Choi, M., Przybyl, L., Binger, K.J., Haase, N., Wilck, N., Heuser, A., Fokuhl, V., Ruland, J., Lucas, P.C., McAllister-Lucas, L.M., Luft, F.C., Dechend, R. and Müller, D.N.
Hypertension 64 (5): 1032-1039. November 2014

Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.
Mosienko, V., Matthes, S., Hirth, N., Beis, D., Flinders, M., Bader, M., Hansson, A.C. and Alenina, N.
Neuropharmacology 85C : 73-80. October 2014

Mas and its related G protein-coupled receptors, Mrgprs.
Bader, M., Alenina, N., Andrade-Navarro, M.A. and Santos, R.A.
Pharmacological Reviews 66 (4): 1080-1105. October 2014

A student-centered approach for developing active learning: the construction of physical models as a teaching tool in medical physiology.
Rezende-Filho, F.M., Da Fonseca, L.J.S., Nunes-Souza, V., Da Silva Guedes, G. and Rabelo, L.A.
BMC Medical Education 14 : 189. 15 September 2014

A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium.
Kuppusamy, M., Caroccia, B., Stindl, J., Bandulik, S., Lenzini, L., Gioco, F., Fishman, V., Zanotti, G., Gomez-Sanchez, C., Bader, M., Warth, R. and Rossi, G.P.
Journal of Clinical Endocrinology and Metabolism 99 (9): E1765-E1773. September 2014

Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis.
Pulgar, V.M., Yamaleyeva, L.M., Varagic, J., McGee, C.M., Bader, M., Dechend, R., Howlett, A.C. and Brosnihan, K.B.
Hypertension 64 (3): 619-625. September 2014

Length polymorphism of the B2-VNTR minisatellite repeat of the bradykinin B2 receptor gene in healthy Russians and patients with coronary heart disease.
Suchkova, I.O., Pavlinova, L.I., Larionova, E.E., Alenina, N.V., Solovyov, K.V., Baranova, T.V., Belotserkovskaya, E.V., Sasina, L.K., Bader, M., Denisenko, A.D., Mustafina, O.E., Khusnutdinova, E.K. and Patkin, E.L.
Molecular Biology 48 (5): 655-663. September 2014

Distribution of non-AT(1), non-AT(2) binding of (125)I-Sarcosine(1), Isoleucine(8) angiotensin II in neurolysin knockout mouse brains.
Speth, R.C., Carrera, E.J., Bretón, C., Linares, A., Gonzalez-Reiley, L., Swindle, J.D., Santos, K.L., Schadock, I., Bader, M. and Karamyan, V.T.
PLoS ONE 9 (8): e105762. 22 August 2014

Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.
Pena Silva, R.A., Kung, D.K., Mitchell, I.J., Alenina, N., Bader, M., Santos, R.A.S., Faraci, F.M., Heistad, D.D. and Hasan, D.M.
Hypertension 64 (2): 362-368. August 2014

Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.
Rosendahl, A., Niemann, G., Lange, S., Ahadzadeh, E., Krebs, C., Contrepas, A., van Goor, H., Wiech, T., Bader, M., Schwake, M., Peters, J., Stahl, R., Nguyen, G. and Wenzel, U.O.
Laboratory Investigation 94 (8): 863-872. August 2014

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J., Kassmann, M., Szijártó, I.A., Hercule, H.C., Tano, J.Y., Weinert, S., Heidenreich, M., Pathan, A.R., Anistan, Y.M., Alenina, N., Rusch, N.J., Bader, M., Jentsch, T.J. and Gollasch, M.
Circulation Research 115 (2): 263-272. 7 July 2014

Overexpression of adenosine A2A receptors in rats: effects on depression, locomotion, and anxiety.
Coelho, J.E., Alves, P., Canas, P.M., Valadas, J.S., Shmidt, T., Batalha, V.L., Ferreira, D.G., Ribeiro, J.A., Bader, M., Cunha, R.A., do Couto, F.S. and Lopes, L.V.
Frontiers in Psychiatry 5 : 67. 13 June 2014

Adenosine (A)2A receptor modulation of nicotine-induced locomotor sensitization: a pharmacological and transgenic approach.
Jastrzebska, J., Nowak, E., Smaga, I., Bystrowska, B., Frankowska, M., Bader, M., Filip, M. and Fuxe, K.
Neuropharmacology 81 : 318-326. June 2014

Neurolysin knockout mice generation and initial phenotype characterization.
Cavalcanti, D.M.L.P., Castro, L.M., Rosa Neto, J.C., Seelaender, M., Neves, R.X., Oliveira, V., Forti, F.L., Iwai, L.K., Gozzo, F.C., Todiras, M., Schadock, I., Barros, C.C., Bader, M. and Ferro, E.S.
Journal of Biological Chemistry 289 (22): 15426-15440. 30 May 2014

Identification of importin alpha 7 specific transport cargoes using a proteomic screening approach.
Hügel, S., Depping, R., Dittmar, G., Rother, F., Cabot, R., Sury, M.D., Hartmann, E. and Bader, M.
Molecular & Cellular Proteomics 13 (5): 1286-1298. 1 May 2014

Relaxin does not improve angiotensin II-induced target-organ damage.
Haase, N., Rugor, J., Przybyl, L., Qadri, F., Müller, D.N. and Dechend, R.
PLoS ONE 9 (4): e93743. 7 April 2014

(Pro)renin receptor and V-ATPase: from Drosophila to humans.
Rousselle, A., Sihn, G., Rotteveel, M. and Bader, M.
Clinical Science 126 (8): 529-536. 1 April 2014

Lower expression of the Twik-related acid-sensitive K(+) channel 2 (TASK-2) gene is a hallmark of aldosterone producing adenoma causing human primary aldosteronism.
Lenzini, L., Caroccia, B., Campos, A.G., Fassina, A., Belloni, A.S., Seccia, T.M., Kuppusamy, M., Ferraro, S., Skander, G., Bader, M., Rainey, W.E. and Rossi, G.P.
Journal of Clinical Endocrinology and Metabolism 99 (4): E674-E682. April 2014

Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5.
Lee, G.S., Simpson, C., Sun, B.H., Yao, C., Foer, D., Sullivan, B., Matthes, S., Alenina, N., Belsky, J., Bader, M. and Insogna, K.L.
Journal of Bone and Mineral Research 29 (4): 976-981. April 2014

Receptor Mas protects mice against hypothermia and mortality induced by endotoxemia.
Souza, L.L., Duchene, J., Todiras, M., Azevedo, L.C.P., Costa-Neto, C.M., Alenina, N., Santos, R.A. and Bader, M.
Shock 41 (4): 331-336. April 2014

Restoration of muscle strength in dystrophic muscle by Angiotensin-1-7 through inhibition of TGF-β signaling.
Acuna, M.J., Pessina, P., Olguin, H., Cabrera, D., Vio, C.P., Bader, M., Munoz-Canoves, P., Santos, R.A., Cabello-Verrugio, C. and Brandan, E.
Human Molecular Genetics 23 (5): 1237-1249. 1 March 2014

Bradykinin in health and disease: proceedings of the Bradykinin Symposium 2012, Berlin 23-24 August 2012.
Magerl, M., Bader, M., Gompel, A., Joseph, K., Kaplan, A.P., Kojda, G., Renné, T., Wirth, M., Maurer, M. and Church, M.K.
Inflammation Research 63 (3): 173-8. March 2014

Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats.
Santos, S.H.S., Giani, J.F., Burghi, V., Miquet, J.G., Qadri, F., Braga, J.F., Todiras, M., Kotnik, K., Alenina, N., Dominici, F.P., Santos, R.A.S. and Bader, M.
Journal of Molecular Medicine 92 (3): 255-265. March 2014

Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention.
Baltatu, O.C., Zaugg, C.E., Schumacher, C., Louie, P., Campos, L.A. and Bader, M.
Pharmacological Research 80 : 9-13. February 2014

Oxidative status imbalance in patients with metabolic syndrome: Role of the myeloperoxidase/hydrogen peroxide axis.
Da Fonseca, L.J.S., Nunes-Souza, V., Guedes, G.D.S., Schettino-Silva, G., Mota-Gomes, M.A. and Rabelo, L.A.
Oxidative Medicine and Cellular Longevity 2014 : 898501. 2014

2013

Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE knockout mice.
Silva, A.R., Aguilar, E.C., Alvarez-Leite, J.I., da Silva, R.F., Arantes, R.M.E., Bader, M., Alenina, N., Pelli, G., Lenglet, S., Galan, K., Montecucco, F., Mach, F., Santos, S.H.S. and Santos, R.A.S.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 305 (11): R1323-R1330. December 2013

Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen.
Kangussu, L.M., Almeida-Santos, A.F., Bader, M., Alenina, N., Fontes, M.A., Santos, R.A., Aguiar, D.C. and Campagnole-Santos, M.J.
Behavioural Brain Research 257 : 25-30. 15 November 2013

Obtainment of chimeric blastocysts of mice by methods of laser nanosurgery.
Shakhbazyan, A.K., Tarantul, V.Z., Zalessky, A.D., Ryabova, A.V., Loshchenov, V.B., Antonov, S.A., Grivennikov, I.A., Krivokharchenko, A.S., Karmenyan, A.V. and Nadtochenko, V.A.
Russian Journal of Developmental Biology 44 (6): 302-306. November 2013

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.
Westphal, C., Spallek, B., Konkel, A., Marko, L., Qadri, F., Degraff, L.M., Schubert, C., Bradbury, J.A., Regitz-Zagrosek, V., Falck, J.R., Zeldin, D.C., Müller, D.N., Schunck, W.H. and Fischer, R.
PLoS ONE 8 (8): e73490. 30 August 2013

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.
Gonzalez, J., Mouttalib, S., Delage, C., Calise, D., Maoret, J.J., Pradere, J.P., Klein, J., Buffin-Meyer, B., Van der Veen, B., Charo, I.F., Heeringa, P., Duchene, J., Bascands, J.L. and Schanstra, J.P.
Biochemical and Biophysical Research Communications 438 (2): 257-263. 23 August 2013

Antinociceptive response in transgenic mice expressing rat tonin.
da Fonseca Pacheco, D., da Fonseca Pacheco, C.M., de Paula Lima, M., Bader, M., de Lima Souza, A., Pesquero, J.L., Castro Perez, A. and Duarte, I.D.G.
European Journal of Pharmacology 713 (1-3): 1-5. 5 August 2013

Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.
Silveira, K.D., Coelho, F.M., Vieira, A.T., Barroso, L.C., Queiroz-Junior, C.M., Costa, V.V., Sousa, L.F.C., Oliveira, M.L., Bader, M., Silva, T.A., Santos, R.A.S., Simoes e Silva, A.C. and Teixeira, M.M.
Peptides 46 : 53-63. August 2013

Kinin B1 receptor gene ablation affects hypothalamic CART production.
Torres, H.A.M., Motta, F.L., Sales, V.M., Batista, C., da Silva, J.M., Vignoli, T., Barnabé, G.F., Goeldner, F.O., D'Almeida, V., Bittencourt, J.C., Sinigaglia-Coimbra, R., Bader, M., Mello, L.E.A.M. and Pesquero, J.B.
Biological Chemistry 394 (7): 901-908. July 2013

Genotype-phenotype correlation of 2q37 deletions including NPPC gene associated with skeletal malformations.
Tassano, E., Buttgereit, J., Bader, M., Lerone, M., Divizia, M.T., Bocciardi, R., Napoli, F., Pala, G., Sloan-Béna, F., Gimelli, S. and Gimelli, G.
PLoS ONE 8 (6): e66048. 21 June 2013

Beneficial effects of the activation of the Angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy.
Silveira, K.D., Barroso, L.C., Vieira, A.T., Cisalpino, D., Lima, C.X., Bader, M., Esteves Arantes, R.M., Souza dos Santos, R.A., Simoes-e-Silva, A.C. and Teixeira, M.M.
PLoS ONE 8 (6): e66082. 7 June 2013

Short-term cardiovascular physical programme ameliorates arterial stiffness and decreases oxidative stress in women with metabolic syndrome.
Eleuterio-Silva, M.A., Sa da Fonseca, L.J., Velloso, E.P.P., da Silva Guedes, G., Sampaio, W.O., da Silva, W.F., Mota-Gomes, M.A., da Silva Lima, L.V., Santos, R.A.S. and Rabelo, L.A.
Journal of Rehabilitation Medicine 45 (6): 572-579. June 2013

Rat model for dominant dystrophic epidermolysis bullosa: glycine substitution reduces collagen VII stability and shows gene-dosage effect.
Nyström, A., Buttgereit, J., Bader, M., Shmidt, T., Özcelik, C., Hausser, I., Bruckner-Tuderman, L. and Kern, J.S.
PLoS ONE 8 (5): e64243. 23 May 2013

Serotonin is required for exercise-induced adult hippocampal neurogenesis.
Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M. and Alenina, N.
Journal of Neuroscience 33 (19): 8270-8275. 8 May 2013

Discovery and characterization of alamandine, a novel component of the renin-angiotensin system.
Lautner, R.Q., Villela, D.C., Fraga-Silva, R.A., Silva, N.C., Verano-Braga, T., Costa-Fraga, F., Jankowski, J., Jankowski, V., De Sousa, F.B., Alzamora, A.C., Soares, E.R., Barbosa, C.M., Kjeldsen, F., Oliveira, A.C., Braga, J.F., Savergnini, S.Q., Etelvino, G.M., Bastos Peluso, A.A., Passos-Silva, D.G., Ferreira, A.J., Alves, F., Martins, A.S., Raizada, M.K., Paula, R.D., Motta-Santos, D., Klempin, F., Pimenta, A.M.C., Alenina, N., Sinisterra, R.D.M., Bader, M., Campagnole-Santos, M.J. and Santos, R.A.S.
Circulation Research 112 (8): 1104-1111. 12 April 2013

Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats.
Liška, F., Gosele, C., Popova, E., Chylíková, B., Krenová, D., Křen, V., Bader, M., Tres, L.L., Hubner, N. and Kierszenbaum, A.L.
PLoS ONE 8 (4): e60859. 8 April 2013

Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin.
Lange, S., Fraune, C., Alenina, N., Bader, M., Danser, A.H.J., Frenay, A.R., van Goor, H., Stahl, R., Nguyen, G., Schwedhelm, E. and Wenzel, U.O.
Journal of Hypertension 31 (4): 713-719. April 2013

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.
Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A. and le Noble, F.
Development 140 (8): 1720-1729. April 2013

Evidence that kinin B(2) receptor expression is upregulated by endothelial overexpression of B(1) receptors.
Rodrigues, E.S., Silva, R.F., Martin, R.P., Macedo Oliveira, S., Nakaie, C.R., Sabatini, R.A., Merino, V.F., Pesquero, J.B., Bader, M. and Shimuta, S.I.
Peptides 42 : 1-7. April 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A., Qadri, F., Leukel, L., Yilmaz, R., Fontaine, J.F., Sihn, G., Bader, M., Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123 (3): 1343-1347. 1 March 2013

AVE 0991, a non-peptide Mas-receptor agonist, facilitates penile erection.
da Costa-Goncalves, A.C., Fraga-Silva, R.A., Leite, R. and Santos, R.A.S.
Experimental Physiology 98 (3): 850-855. March 2013

Role of kinin B2 receptors in opioid-induced-hyperalgesia in inflammatory pain in mice.
Grastilleur, S., Mouledous, L., Bedel, J., Etcheverry, J., Bader, M., Girolami, J.P., Fourcade, O., Frances, B. and Minville, V.
Biological Chemistry 394 (3): 361-368. March 2013

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
Katter, K., Geurts, A.M., Hoffmann, O., Mátés, L., Landa, V., Hiripi, L., Moreno, C., Lazar, J., Bashir, S., Zidek, V., Popova, E., Jerchow, B., Becker, K., Devaraj, A., Walter, I., Grzybowksi, M., Corbett, M., Filho, A.R., Hodges, M.R., Bader, M., Ivics, Z., Jacob, H.J., Pravenec, M., Bosze, Z., Rülicke, T. and Izsvák, Z.
FASEB Journal 27 (3): 930-941. March 2013

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.
Duerschmied, D., Suidan, G.L., Demers, M., Herr, N., Carbo, C., Brill, A., Cifuni, S.M., Mauler, M., Cicko, S., Bader, M., Idzko, M., Bode, C. and Wagner, D.D.
Blood 121 (6): 1008-1015. 7 February 2013

Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease.
Kränkel, N., Kuschnerus, K., Müller, M., Speer, T., Mocharla, P., Madeddu, P., Bader, M., Lüscher, T.F. and Landmesser, U.
Circulation 127 (5): 594-603. 5 February 2013

Functional cross-talk between aldosterone and angiotensin-(1-7) in ventricular myocytes.
Machado de Almeida, P.W., de Freitas Lima, R., de Morais Gomes, E.R., Rocha-Resende, C., Roman-Campos, D., Gondim, A.N.S., Gavioli, M., Lara, A., Parreira, A., de Azevedo Nunes, S.L., Alves, M.N.M., Lauton Santos, S., Alenina, N., Bader, M., Ribeiro Resende, R., dos Santos Cruz, J., Souza dos Santos, R.A. and Guatimosim, S.
Hypertension 61 (2): 425-430. February 2013

Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin angiotensin system.
Santos, R.A.S., Ferreira, A.J., Verano-Braga, T. and Bader, M.
Journal of Endocrinology 216 (2): R1-R17. 18 January 2013

Postnatal growth defects in mice with constitutive depletion of central serotonin.
Narboux-Neme, N., Angenard, G., Mosienko, V., Klempin, F., Pitychoutis, P.M., Deneris, E., Bader, M., Giros, B., Alenina, N. and Gaspar, P.
ACS Chemical Neuroscience 4 (1): 171-181. 16 January 2013

(Pro)renin receptor: subcellular localizations and functions.
Sihn, G., Burckle, C., Rousselle, A., Reimer, T. and Bader, M.
Frontiers in Bioscience 5 : 500-508. 1 January 2013

Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm.
Chuykin, I., Schulz, H., Guan, K. and Bader, M.
Journal of Cell Science 126 (Pt 1): 128-138. 1 January 2013

ACE2, angiotensin-(1-7), and Mas: the other side of the coin.
Bader, M.
Pfluegers Archiv European Journal of Physiology 465 (1): 79-85. January 2013

Antioxidant/oxidant status and cardiac function in bradykinin B(1)- and B(2)-receptor null mice.
Delemasure, S., Blaes, N., Richard, C., Couture, R., Bader, M., Dutartre, P., Girolami, J.P., Connat, J.L. and Rochette, L.
Physiological Research 62 (5): 511-517. 2013

The Angiotensin-melatonin axis.
Campos, L.A., Cipolla-Neto, J., Amaral, F.G., Michelini, L.C., Bader, M. and Baltatu, O.C.
International Journal of Hypertension 2013 : 521783. 2013

2012

Laser fusion of mouse embryonic cells and intra-embryonic fusion of blastomeres without affecting the embryo integrity.
Krivokharchenko, A., Karmenyan, A., Sarkisov, O., Bader, M., Chiou, A. and Shakhbazyan, A.
PLoS ONE 7 (12): e50029. 5 December 2012

New therapeutic pathways in the RAS.
Bader, M., Santos, R.A., Unger, T. and Steckelings, U.M.
Journal of the Renin Angiotensin Aldosterone System 13 (4): 505-508. December 2012

Exercise induces renin-angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice.
Guimaraes, G.G., Santos, S.H.S., Oliveira, M.L., Pimenta-Veloso, E.P., Motta, D.F., Martins, A.S., Alenina, N., Bader, M., Santos, R.A.S. and Campagnole-Santos, M.J.
Peptides 38 (1): 54-61. November 2012

Increased circulating angiotensin-(1-7) protects white adipose tissue against development of a proinflammatory state stimulated by high-fat diet.
Santos, S.H.S., Rodrigues Fernandes, L., Santos Pereira, C., Senna Guimaraes, A.L., de Paula, A.M.B., Campagnole-Santos, M.J., Alvarez-Leite, J.I., Bader, M. and Santos, R.A.S.
Regulatory Peptides 178 (1-3): 64-70. 10 October 2012

Altered regional blood flow distribution in Mas-deficient mice.
Botelho-Santos, G.A., Bader, M., Alenina, N. and Santos, R.A.
Therapeutic Advances in Cardiovascular Disease 6 (5): 201-211. October 2012

Bradykinin inhibits hepatic gluconeogenesis in obese mice.
Castilho Barros, C., Haro, A., Russo, F.J., Schadock, I., Soares Almeida, S., Castellani Reis, F., Rocha Moraes, M., Haidar, A., Hirata, A.E., Mori, M.A., Pereira Bacurau, R.F., Wuertele, M., Bader, M., Bosco Pesquero, J. and Araujo, R.C.
Laboratory Investigation 92 (10): 1419-1427. October 2012

Decreased hepatic gluconeogenesis in transgenic rats with increased circulating angiotensin-(1-7).
Bilman, V., Mares-Guia, L., Nadu, A.P., Bader, M., Campagnole-Santos, M.J., Santos, R.A.S. and Santos, S.H.S.
Peptides 37 (2): 247-251. October 2012

Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.
Chan, M.V., Bubb, K.J., Noyce, A., Villar, I.C., Duchene, J., Hobbs, A.J., Scotland, R.S. and Ahluwalia, A.
British Journal of Pharmacology 167 (4): 805-817. October 2012

Endothelium dependent expression and underlying mechanisms of des-Arg(9)-bradykinin-induced B(1)R-mediated vasoconstriction in rat portal vein.
Basei, F.L., Cabrini, D.A., Figueiredo, C.P., Forner, S., Hara, D.B., Nascimento, A.F.Z., Ceravolo, G.S., Carvalho, M.H.C., Bader, M., Medeiros, R. and Calixto, J.B.
Peptides 37 (2): 216-224. October 2012

Kinin b(1) receptor in adipocytes regulates glucose tolerance and predisposition to obesity.
Mori, M.A., Sales, V.M., Motta, F.L., Fonseca, R.G., Alenina, N., Guadagnini, D., Schadock, I., Silva, E.D., Torres, H.A., Dos Santos, E.L., Castro, C.H., D'Almeida, V., Andreotti, S., Campana, A.B., Sertie, R.A., Saad, M.J., Lima, F.B., Bader, M. and Pesquero, J.B.
PLoS ONE 7 (9): e44782. 14 September 2012

Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
Albert-Weissenberger, C., Stetter, C., Meuth, S.G., Goebel, K., Bader, M., Siren, A.L. and Kleinschnitz, C.
Journal of Cerebral Blood Flow and Metabolism 32 (9): 1747-1756. September 2012

Blood pressure and renin-angiotensin system resetting in transgenic rats with elevated plasma Val5-angiotensinogen.
Bohlender, J., Bader, M., Menard, J. and Nussberger, J.
Journal of Hypertension 30 (8): 1597-1605. August 2012

Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes.
Barros, C.C., Haro, A., Russo, F.J.V.P., Schadock, I., Almeida, S.S., Ribeiro, R.A., Vanzela, E.C., Lanzoni, V.P., Barros, F.C., Moraes, M.R., Mori, M.A., Bacurau, R.F.P., Wurtele, M., Boschero, A.C., Carneiro, E.M., Bader, M., Pesquero, J.B. and Araujo, R.C.
PLoS ONE 7 (7): e40573. 19 July 2012

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.
Mosienko, V., Bert, B., Beis, D., Matthes, S., Fink, H., Bader, M. and Alenina, N.
Translational Psychiatry 2 (5): e122. 29 May 2012

Emergence and evolution of the renin-angiotensin-aldosterone system.
Fournier, D., Luft, F.C., Bader, M., Ganten, D. and Andrade-Navarro, M.A.
Journal of Molecular Medicine 90 (5): 495-508. May 2012

Pioglitazone prevents capillary rarefaction in streptozotocin-diabetic rats independently of glucose control and vascular endothelial growth factor expression.
Ashoff, A., Qadri, F., Eggers, R., Joehren, O., Raasch, W. and Dendorfer, A.
Journal of Vascular Research 49 (3): 260-266. May 2012

Therapeutic targeting of the angiotensin-converting enzyme 2/Angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review.
Ferreira, A.J., Bader, M. and Santos, R.A.S.
Expert Opinion on Therapeutic Patents 22 (5): 567-574. May 2012

Regulation of karyopherin alpha1 and nuclear import by mammalian target of rapamycin.
Fielhaber, J.A., Tan, J., Joung, K.B., Attias, O., Huegel, S., Bader, M., Roux, P.P. and Kristof, A.S.
Journal of Biological Chemistry 287 (18): 14325-14335. 27 April 2012

Cardiovascular responses evoked by activation or blockade of GABA(A) receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen.
Gomes da Silva, A.Q., Xavier, C.H., Campagnole-Santos, M.J., Caligiorne, S.M., Baltatu, O.C., Bader, M., Santos, R.A. and Fontes, M.A.
Brain Research 1448 : 101-110. 11 April 2012

Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart.
Gava, E., de Castro, C.H., Ferreira, A.J., Colleta, H., Melo, M.B., Alenina, N., Bader, M., Oliveira, L.A., Santos, R.A.S. and Kitten, G.T.
Regulatory Peptides 175 (1-3): 30-42. 10 April 2012

Generation of rat-induced pluripotent stem cells: reprogramming and culture medium.
Liskovykh, M.A., Chuykin, I.A., Ranjan, A., Safina, D.A., Tolkunova, E.N., Minina, Y.M., Zhdanova, N.S., Dyban, P.A., Mullins, J.J., Kostyleva, E.I., Chikhirzhina, E.V., Bader, M., Alenina, N. and Tomilin, A.N.
Cell and Tissue Biology 6 (2): 115-121. April 2012

Genetic manipulations and examination of differentiation properties of rat induced pluripotent cells.
Liskovykh, M.A., Chuykin, I.A., Ranjan, A., Popova, E., Tolkunova, E.N., Chechik, L.L., Malinin, A.Y., Morozova, A.V., Mosienko, V., Bader, M., Alenina, N. and Tomilin, A.N.
Cell and Tissue Biology 6 (2): 122-127. April 2012

Impaired nociception and peripheral opioid antinociception in mice lacking both kinin b1 and b2 receptors.
Cayla, C., Labuz, D., Machelska, H., Bader, M., Schaefer, M. and Stein, C.
Anesthesiology 116 (2): 448-457. February 2012

Axonal transcription factors signal retrogradely in lesioned peripheral nerve.
Ben-Yaakov, K., Dagan, S.Y., Segal-Ruder, Y., Shalem, O., Vuppalanchi, D., Willis, D.E., Yudin, D., Rishal, I., Rother, F., Bader, M., Blesch, A., Pilpel, Y., Twiss, J.L. and Fainzilber, M.
EMBO Journal 31 (6): 1350-1363. 13 January 2012

Brain renin-angiotensin system in hypertension, cardiac hypertrophy, and heart failure.
Campos, L.A., Bader, M. and Baltatu, O.C.
Frontiers in Physiology 2 : 115. 3 January 2012

Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-AT1, non-AT2 angiotensin binding site.
Wangler, N.J., Santos, K.L., Schadock, I., Hagen, F.K., Escher, E., Bader, M., Speth, R.C. and Karamyan, V.T.
Journal of Biological Chemistry 287 (1): 114-122. 2 January 2012

Angiotensin-(1-7) Mas-receptor deficiency decreases peroxisome proliferator-activated receptor gamma expression in adipocytes.
Mario, E.G., Santos, S.H.S., Ferreira, A.V.M., Bader, M., Santos, R.A.S. and Botion, L.M.
Peptides 33 (1): 174-177. January 2012

Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory.
Lazaroni, T.L.N., Raslan, A.C.S., Fontes, W.R.P., de Oliveira, M.L., Bader, M., Alenina, N., Moraes, M.F.D., Dos Santos, R.A. and Pereira, G.S.
Neurobiology of Learning and Memory 97 (1): 113-123. January 2012

Renoprotective effects of AVE0991, a nonpeptide Mas receptor agonist, in experimental acute renal injury.
Barroso, L.C., Silveira, K.D., Lima, C.X., Borges, V., Bader, M., Rachid, M., Souza Santos, R.A., Souza, D.G., Simoes e Silva, A.C. and Teixeira, M.M.
International Journal of Hypertension 2012 : 808726. 2012

2011

Emerging drugs which target the renin-angiotensin-aldosterone system.
Steckelings, U.M., Paulis, L., Unger, T. and Bader, M.
Expert Opinion on Emerging Drugs 16 (4): 619-630. December 2011

Prorenin receptor is essential for podocyte autophagy and survival.
Riediger, F., Quack, I., Qadri, F., Hartleben, B., Park, J.K., Potthoff, S.A., Sohn, D., Sihn, G., Rousselle, A., Fokuhl, V., Maschke, U., Purfürst, B., Schneider, W., Rump, L.C., Luft, F.C., Dechend, R., Bader, M., Huber, T.B., Nguyen, G. and Mueller, D.N.
Journal of the American Society of Nephrology 22 (12): 2193-2202. December 2011

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats.
Liskovykh, M., Chuykin, I., Ranjan, A., Safina, D., Popova, E., Tolkunova, E., Mosienko, V., Minina, J.M., Zhdanova, N.S., Mullins, J.J., Bader, M., Alenina, N. and Tomilin, A.
PLoS ONE 6 (11): e27345. 4 November 2011

Kallikrein-kinin system in inflammation.
Duchene, J. and Ahluwalia, A.
In: Kinins. de Gruyter, 261-272. ISBN 978-3-11-025234-7 November 2011

Kinins.
Bader, M.
de Gruyter. ISBN 978-3-11-025234-7 November 2011

Kinins: History and outlook.
Bader, M.
In: Kinins. de Gruyter, 1-6. ISBN 978-3-11-025234-7 November 2011

New topics in bradykinin research.
Maurer, M., Bader, M., Bas, M., Bossi, F., Cicardi, M., Cugno, M., Howarth, P., Kaplan, A., Kojda, G., Leeb-Lundberg, F., Loetvall, J. and Magerl, M.
Allergy 66 (11): 1397-1406. November 2011

Stress worsens endothelial function and ischemic stroke via glucocorticoids.
Balkaya, M., Prinz, V., Custodis, F., Gertz, K., Kronenberg, G., Kroeber, J., Fink, K., Plehm, R., Gass, P., Laufs, U. and Endres, M.
Stroke 42 (11): 3258-3264. November 2011

B(1) and B(2) kinin receptor participation in hyperproliferative and inflammatory skin processes in mice.
Pietrovski, E.F., Paludo, K.S., Mendes, D.A., Guimaraes, F.D., Veiga, S.S., Buchi, D.D., Fonseca, R.G., Zampronio, A.R., Bader, M., Pesquero, J.B., Ferreira, J., Otuki, M.F. and Cabrini, D.A.
Journal of Dermatological Science 64 (1): 23-30. October 2011

Mas receptors in modulating relaxation induced by perivascular adipose tissue.
Lee, R.M.K.W., Bader, M., Alenina, N., Santos, R.A.S., Gao, Y.J. and Lu, C.
Life Sciences 89 (13-14): 467-472. 26 September 2011

Angioprotectin: an angiotensin II-like peptide causing vasodilatory effects.
Jankowski, V., Toelle, M., Santos, R.A., Guenthner, T., Krause, E., Beyermann, M., Welker, P., Bader, M., Pinheiro, S.V.B., Sampaio, W.O., Lautner, R., Kretschmer, A., van der Giet, M., Zidek, W. and Jankowski, J.
FASEB Journal 25 (9): 2987-2995. September 2011

Arteriogenesis is modulated on bradykinin receptor signaling.
Hillmeister, P., Gatzke, N., Duelsner, A., Bader, M., Schadock, I., Hoefer, I., Hamann, I., Infante-Duarte, C., Jung, G., Troidl, K., Urban, D., Stawowy, P., Frentsch, M., Li, M., Nagorka, S., Wang, H., Shi, Y., le Noble, F. and Buschmann, I.
Circulation Research 109 (5): 524-533. 19 August 2011

Lrp5 functions in bone to regulate bone mass.
Cui, Y., Niziolek, P.J., Macdonald, B.T., Zylstra, C.R., Alenina, N., Robinson, D.R., Zhong, Z., Matthes, S., Jacobsen, C.M., Conlon, R.A., Brommage, R., Liu, Q., Mseeh, F., Powell, D.R., Yang, Q.M., Zambrowicz, B., Gerrits, H., Gossen, J.A., He, X., Bader, M., Williams, B.O., Warman, M.L. and Robling, A.G.
Nature Medicine 17 (6): 684-691. June 2011

Platelet-derived serotonin links vascular disease and tissue fibrosis.
Dees, C., Akhmetshina, A., Zerr, P., Reich, N., Palumbo, K., Horn, A., Juengel, A., Beyer, C., Kroenke, G., Zwerina, J., Reiter, R., Alenina, N., Maroteaux, L., Gay, S., Schett, G., Distler, O. and Distler, J.H.
Journal of Experimental Medicine 208 (5): 961-972. 9 May 2011

Angiotensin II binding to angiotensin I-converting enzyme triggers calcium signaling.
Guimaraes, P.B., Alvarenga, E.C., Siqueira, P.D., Paredes-Gamero, E.J., Sabatini, R.A., Morais, R.L., Reis, R.I., Santos, E.L., Teixeira, L.G., Casarini, D.E., Martin, R.P., Shimuta, S.I., Carmona, A.K., Nakaie, C.R., Jasiulionis, M.G., Ferreira, A.T., Pesquero, J.L., Oliveira, S.M., Bader, M., Costa-Neto, C.M. and Pesquero, J.B.
Hypertension 57 (5): 965-972. May 2011

Local renin angiotensin system and the brain-A continuous quest for knowledge.
Baltatu, O.C., Campos, L.A. and Bader, M.
Peptides 32 (5): 1083-1086. May 2011

Effect of culture conditions on viability of mouse and rat embryos developed in vitro.
Popova, E., Bader, M. and Krivokharchenko, A.
Genes 2 (2): 332-344. 1 April 2011

Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
Rothman, R.B., Cadet, J.L., Dersch, C.M., McCoy, M.T., Lehrmann, E., Becker, K.G., Bader, M., Alenina, N. and Baumann, M.H.
PLoS ONE 6 (3): e17735. 25 March 2011

Effects of electric field on early preimplantation development in vitro in mice and rats.
Popova, E., Bader, M. and Krivokharchenko, A.
Human Reproduction 26 (3): 662-670. March 2011

Importin alpha7 is essential for zygotic genome activation and early mouse development.
Rother, F., Shmidt, T., Popova, E., Krivokharchenko, A., Huegel, S., Vilianovich, L., Ridders, M., Tenner, K., Alenina, N., Koehler, M., Hartmann, E. and Bader, M.
PLoS ONE 6 (3): e18310. March 2011

Controlling cardiomyocyte length: The role of renin and PPAR-γ.
Hinrichs, S., Heger, J., Schreckenberg, R., Wenzel, S., Euler, G., Arens, C., Bader, M., Rosenkranz, S., Caglayan, E. and Schlueter, K.D.
Cardiovascular Research 89 (2): 344-352. 1 February 2011

ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease.
Rabelo, L.A., Alenina, N. and Bader, M.
Hypertension Research 34 (2): 154-160. February 2011

Forced expression of Lmx1b enhances differentiation of mouse ES cells into serotonergic neurons.
Dolmazon, V., Alenina, N., Markossian, S., Mancip, J., Van de Vrede, Y., Fontaine, E., Dehay, C., Kennedy, H., Bader, M., Savatier, P. and Bernat, A.
Stem Cells and Development 20 (2): 301-311. February 2011

Functional expression of angiotensinogen depends on splicing enhancers in exon 2.
Cardoso, C.C., Cabrini, D.A., May, M., Bhagat, C.S., Eleno, N., Cayla, C., Walther, T. and Bader, M.
Molecular and Cellular Endocrinology 332 (1-2): 228-233. 30 January 2011

ACE activity is modulated by the enzyme alpha-galactosidase A.
Batista, E.C., Carvalho, L.R., Casarini, D.E., Carmona, A.K., Dos Santos, E.L., da Silva, E.D., Dos Santos, R.A., Nakaie, C.R., Rojas, M.V., de Oliveira, S.M., Bader, M., D'Almeida, V., Martins, A.M., de Picoly Souza, K. and Pesquero, J.B.
Journal of Molecular Medicine 89 (1): 65-74. January 2011

Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus.
Gabriel, G., Klingel, K., Otte, A., Thiele, S., Hudjetz, B., Arman-Kalcek, G., Sauter, M., Shmidt, T., Rother, F., Baumgarte, S., Keiner, B., Hartmann, E., Bader, M., Brownlee, G.G., Fodor, E. and Klenk, H.D.
Nature Communications 2 (1): 156. January 2011

SDF-1alpha as a therapeutic stem cell homing factor in myocardial infarction.
Ghadge, S.K., Muehlstedt, S., Oezcelik, C. and Bader, M.
Pharmacology & Therapeutics 129 (1): 97-108. January 2011

An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect.
Fraga-Silva, R.A., Costa-Fraga, F.P., Sousa, F.B., Alenina, N., Bader, M., Sinisterra, R.D. and Santos, R.A.
Clinics 66 (5): 837-841. 2011

Generation of rat induced pluripotent stem cells: the analysis of reprogramming and culturing media.
Liskovykh, M.A., Chuykin, I.A., Ranjan, A., Safina, D.A., Tolkunova, E.N., Minina, Y.M., Zhdanova, N.S., Dyban, P.A,, Mullins, J., Kostyleva, E.I., Chikhirzhina, E.V., Bader, M., Alenina, N. and Tomilin, A.N.
Tsitologiia 53 (12): 939-945. 2011

2010

Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
Pohl, M., Kaminski, H., Castrop, H., Bader, M., Himmerkus, N., Bleich, M., Bachmann, S. and Theilig, F.
Journal of Biological Chemistry 285 (53): 41935-41946. 31 December 2010

Knockout of angiotensin 1-7 receptor Mas worsens the course of two-kidney, one-clip Goldblatt hypertension: roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II.
Rakusan, D., Buergelova, M., Vaneckova, I., Vanourkova, Z., Huskova, Z., Skaroupkova, P., Mrazova, I., Opocensky, M., Kramer, H.J., Netuka, I., Maly, J., Alenina, N., Bader, M., Santos, R.A.S. and Cervenka, L.
Kidney and Blood Pressure Research 33 (6): 476-488. December 2010

Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, Mas, in experimental models of arthritis.
Silveira, K.D., Coelho, F.M., Vieira, A.T., Sachs, D., Barroso, L.C., Costa, V.V., Bretas, T.L.B., Bader, M., Sousa, L.P., Silva, T.A., Santos, R.A.S., Simoes E Silva, A.C. and Teixeira, M.M.
Journal of Immunology 185 (9): 5569-5576. 1 November 2010

The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.
Werth, M., Walentin, K., Aue, A., Schoenheit, J., Wuebken, A., Pode-Shakked, N., Vilianovitch, L., Erdmann, B., Dekel, B., Bader, M., Barasch, J., Rosenbauer, F., Luft, F.C. and Schmidt-Ott, K.M.
Development 137 (22): 3835-3845. November 2010

Altered cardiovascular reflexes responses in conscious angiotensin-(1-7) receptor Mas knockout mice.
Moura, M.M., Souza dos Santos, R.A., Campagnole-Santos, M.J., Todiras, M., Bader, M., Alenina, N. and Haibara, A.S.
Peptides 31 (10): 1934-1939. October 2010

Anxiety-related behaviour of low brain angiotensinogen transgenic rats in the canopy test.
Voigt, J.P., Bader, M., Bert, B., Fink, H. and Rex, A.
Pharmacology Biochemistry and Behavior 96 (4): 429-437. October 2010

Cardiac magnetic field mapping quantified by Kullback-Leibler entropy detects patients with coronary artery disease.
Gapelyuk, A., Schirdewan, A., Fischer, R. and Wessel, N.
Physiological Measurement 31 (10): 1345-1354. October 2010

Leptin regulates ACE activity in mice.
Hilzendeger, A.M., Morais, R.L., Todiras, M., Plehm, R., da Costa Goncalves, A., Qadri, F., Araujo, R.C., Gross, V., Nakaie, C.R., Casarini, D.E., Carmona, A.K., Bader, M. and Pesquero, J.B.
Journal of Molecular Medicine 88 (9): 899-907. September 2010

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
Raslan, F., Schwarz, T., Meuth, S.G., Austinat, M., Bader, M., Renne, T., Roosen, K., Stoll, G., Siren, A.L. and Kleinschnitz, C.
Journal of Cerebral Blood Flow and Metabolism 30 (8): 1477-1486. August 2010

Physiology of the (pro)renin receptor: Wnt of change?
Sihn, G., Rousselle, A., Vilianovitch, L., Burckle, C. and Bader, M.
Kidney International 78 (3): 246-256. August 2010

Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction.
Filip, M., Alenina, N., Bader, M. and Przegalinski, E.
Addiction Biology 15 (3): 227-249. July 2010

Genexpression und Morphologie der Follikel nach konventionellem Einfrieren und Vitrifikation von humanem Ovarialgewebe [Gene-expression and morphology of follicles after conventional freezing and vitrification of human ovarian tissue].
Isachenko, V., Isachenko, E., Nawroth, F., Wiegratz, I., Kaufmann, M., Lapidus, I., Hancke, K. and Kreienberg, R.
Geburtshilfe und Frauenheilkunde 70 (7): 561-567. July 2010

Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the Mas receptor.
Savergnini, S.Q., Beiman, M., Lautner, R.Q., de Paula-Carvalho, V., Allahdadi, K., Pessoa, D.C., Costa-Fraga, F.P., Fraga-Silva, R.A., Cojocaru, G., Cohen, Y., Bader, M., de Almeida, A.P., Rotman, G. and Santos, R.A.
Hypertension 56 (1): 112-120. July 2010

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2.
Reiche, J., Theilig, F., Rafiqi, F.H., Carlo, A.S., Militz, D., Mutig, K., Todiras, M., Christensen, E.I., Ellison, D.H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. and Willnow, T.E.
Molecular and Cellular Biology 30 (12): 3027-3037. June 2010

Bradykinin B2 receptor agonism: a novel therapeutic strategy for myocardial infarction?
Duchene, J. and Bader, M.
American Journal of Hypertension 23 (5): 459. May 2010

Improved lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7).
Santos, S.H., Felix Braga, J., Mario, E.G., Porto, L.C., Rodrigues-Machado, M.D., Murari, A., Botion, L.M., Alenina, N., Bader, M. and Santos, R.A.
Arteriosclerosis Thrombosis and Vascular Biology 30 (5): 953-61. May 2010

Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.
Buttgereit, J., Qadri, F., Monti, J., Langenickel, T.H., Dietz, R., Braunewell, K.H. and Bader, M.
Regulatory Peptides 161 (1-3): 51-57. 9 April 2010

Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart.
Ferreira, A.J., Castro, C.H., Guatimosim, S., Almeida, P.W.M., Gomes, E.R.M., Dias-Peixoto, M.F., Alves, M.N.A., Fagundes-Moura, C.R., Rentzsch, B., Gava, E., Almeida, A.P., Guimaraes, A.M., Kitten, G.T., Reudelhuber, T., Bader, M. and Santos, R.A.S.
Therapeutic Advances in Cardiovascular Disease 4 (2): 83-96. April 2010

Autonomic dysregulation in ob/ob mice is improved by inhibition of angiotensin-converting enzyme.
Hilzendeger, A.M., da Costa Goncalves, A.C., Plehm, R., Diedrich, A., Gross, V., Pesquero, J.B. and Bader, M.
Journal of Molecular Medicine 88 (4): 383-390. April 2010

Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor κB.
Rompe, F., Artuc, M., Hallberg, A., Alterman, M., Stroeder, K., Thoene-Reineke, C., Reichenbach, A., Schacherl, J., Dahloef, B., Bader, M., Alenina, N., Schwaninger, M., Zuberbier, T., Funke-Kaiser, H., Schmidt, C., Schunck, W.H., Unger, T. and Steckelings, U.M.
Hypertension 55 (4): 924-931. April 2010

Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain.
Cardoso, C.C., Alenina, N., Ferreira, A.J., Qadri, F., Lima, M.P., Gross, V., Todiras, M., Pesquero, J.B., Pesquero, J.L. and Bader, M.
Biological Chemistry 391 (4): 435-441. April 2010

Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos.
Chuykin, I., Lapidus, I., Popova, E., Vilianovich, L., Mosienko, V., Alenina, N., Binas, B., Chai, G., Bader, M. and Krivokharchenko, A.
PLoS ONE 5 (3): e9794. 29 March 2010

The past, present and future of angiotensin II type 2 receptor stimulation.
Steckelings, U.M., Rompe, F., Kaschina, E., Namsolleck, P., Grzesiak, A., Funke-Kaiser, H., Bader, M. and Unger, T.
Journal of the Renin Angiotensin Aldosterone System 11 (1): 67-73. March 2010

alpha(1A)-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats.
Wenzel, K., Wallukat, G., Qadri, F., Huebner, N., Schulz, H., Hummel, O., Herse, F., Heuser, A., Fischer, R., Heidecke, H., Luft, F.C., Mueller, D.N., Dietz, R. and Dechend, R.
PLoS ONE 5 (2): e9409. 24 February 2010

Signal transduction in CHO-cells stably transfected with domain-selective forms of murine ACE.
Sun, X., Rentzsch, B., Gong, M., Eichhorst, J., Pankow, K., Papsdorf, G., Maul, B., Bader, M. and Siems, W.E.
Biological Chemistry 391 (2-3): 235-244. February 2010

Alternative splicing and extensive RNA editing of human TPH2 transcripts.
Grohmann, M., Hammer, P., Walther, M., Paulmann, N., Buettner, A., Eisenmenger, W., Baghai, T.C., Schuele, C., Rupprecht, R., Bader, M., Bondy, B., Zill, P., Priller, J. and Walther, D.J.
PLoS ONE 5 (1): e8956. 29 January 2010

Angiotensin-(1-7) prevents cardiomyocyte pathological remodeling through a nitric oxide/guanosine 3',5'-cyclic monophosphate-dependent pathway.
Gomes, E.R., Lara, A.A., Almeida, P.W., Guimaraes, D., Resende, R.R., Campagnole-Santos, M.J., Bader, M., Santos, R.A. and Guatimosim, S.
Hypertension 55 (1): 153-160. January 2010

Stress sensitivity is increased in transgenic rats with low brain angiotensinogen.
Mueller, H., Kroeger, J., Joehren, O., Szymczak, S., Bader, M., Dominiak, P. and Raasch, W.
Journal of Endocrinology 204 (1): 85-92. January 2010

The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice.
Trabold, R., Eroes, C., Zweckberger, K., Relton, J., Beck, H., Nussberger, J., Mueller-Esterl, W., Bader, M., Whalley, E. and Plesnila, N.
Journal of Cerebral Blood Flow and Metabolism 30 (1): 130-139. January 2010

Rat models of cardiovascular diseases.
Bader, M.
Methods in Molecular Biology 597 : 403-414. 2010

Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.
Bader, M.
Annual Review of Pharmacology and Toxicology 50 : 439-65. 2010

Tryptophan hydroxylase as novel target for the treatment of depressive disorders.
Matthes, S., Mosienko, V., Bashammakh, S., Alenina, N. and Bader, M.
Pharmacology 85 (2): 95-109. 2010

2009

The possibilities of optical laser technologies in cell engineering.
Shakhbazyan, A.K., Karmenyan, A.K., Sviridova-Chailakhyan, T.A., Krivokharchenko, A.S., Chiou, A. and Chailakhyan, L.M.
Doklady Biological Sciences 429 (1): 587-590. December 2009

Central control of fever and female body temperature by RANKL/RANK.
Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., Klaere, S., Komnenovic, V., Mimata, H., Yoshimatsu, H., Takahashi, N., von Haeseler, A., Bader, M., Kilic, S.S., Ueta, Y., Pifl, C., Narumiya, S. and Penninger, J.M.
Nature 462 (7272): 505-509. 26 November 2009

Developmental renin expression in mice with defective renin angiotensin system.
Machura, K., Steppan, D., Neubauer, B., Alenina, N., Coffman, T.M., Facemire, C.M., Hilgers, K.F., Eckardt, K.U., Wagner, C. and Kurtz, A.
American Journal of Physiology Renal Physiology 297 (5): F1371-F1380. November 2009

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Paulmann, N., Grohmann, M., Voigt, J.P., Bert, B., Vowinckel, J., Bader, M., Skelin, M., Jevsek, M., Fink, H., Rupnik, M. and Walther, D.J.
PLoS Biology 7 (10): e1000229. 27 October 2009

Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension.
Buergelova, M., Vanourkova, Z., Thumova, M., Dvorak, P., Opocensky, M., Kramer, H.J., Zelizko, M., Maly, J., Bader, M. and Cervenka, L.
Journal of Hypertension 27 (10): 1988-2000. October 2009

Predisposition to atherosclerosis and aortic aneurysms in mice deficient in kinin B1 receptor and apolipoprotein E.
Merino, V.F., Todiras, M., Mori, M.A., Sales, V.M., Fonseca, R.G., Saul, V., Tenner, K., Bader, M. and Pesquero, J.B.
Journal of Molecular Medicine 87 (10): 953-963. October 2009

The use of laser for obtaining recipient cytoplasts for mammalian nuclear transfer.
Shakhbazyan, A.K., Sviridova-Chailakhyan, T.A., Karmenyan, A.K., Krivokharchenko, A.S., Chiou, A. and Chailakhyan, L.M.
Doklady Biological Sciences 428 : 475-478. October 2009

Use of picosecond infrared laser for micromanipulation of early mammalian embryos.
Karmenyan, A.V., Shakhbazyan, A.K., Sviridova-Chailakhyan, T.A., Krivokharchenko, A.S., Chiou, A.E. and Chailakhyan, L.M.
Molecular Reproduction and Development 76 (10): 975-983. October 2009

Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.
Debeb, B.G., Galat, V., Epple-Farmer, J., Iannaccone, S., Woodward, W.A., Bader, M., Iannaccone, P. and Binas, B.
PLoS ONE 4 (9): e7216. 28 September 2009

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation.
Schulz, H., Kolde, R., Adler, P., Aksoy, I., Anastassiadis, K., Bader, M., Billon, N., Boeuf, H., Bourillot, P.Y., Buchholz, F., Dani, C., Doss, M.X., Forrester, L., Gitton, M., Henrique, D., Hescheler, J., Himmelbauer, H., Huebner, N., Karantzali, E., Kretsovali, A., Lubitz, S., Pradier, L., Rai, M., Reimand, J., Rolletschek, A., Sachinidis, A., Savatier, P., Stewart, F., Storm, M.P., Trouillas, M., Vilo, J., Welham, M.J., Winkler, J., Wobus, A.M. and Hatzopoulos, A.K.
PLoS ONE 4 (9): e6804. 3 September 2009

Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta.
Rodrigues, E.S., Martin, R.P., Felipe, S.A., Bader, M., Oliveira, S.M. and Shimuta, S.I.
Biological Chemistry 390 (9): 907-913. September 2009

Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system.
Filip, M. and Bader, M.
Pharmacological Reports 61 (5): 761-777. September 2009

Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease.
Gramlich, M., Michely, B., Krohne, C., Heuser, A., Erdmann, B., Klaassen, S., Hudson, B., Magarin, M., Kirchner, F., Todiras, M., Granzier, H., Labeit, S., Thierfelder, L. and Gerull, B.
Journal of Molecular and Cellular Cardiology 47 (3): 352-358. September 2009

Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload.
Panek, A.N., Posch, M.G., Alenina, N., Ghadge, S.K., Erdmann, B., Popova, E., Perrot, A., Geier, C., Dietz, R., Morano, I., Bader, M. and Oezcelik, C.
PLoS ONE 4 (8): e6743. 25 August 2009

Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
Seebohm, B., Matinmehr, F., Koehler, J., Francino, A., Navarro-Lopez, F., Perrot, A., Oezcelik, C., McKenna, W.J., Brenner, B. and Kraft, T.
Biophysical Journal 97 (3): 806-824. 5 August 2009

A role of the (pro)renin receptor in neuronal cell differentiation.
Contrepas, A., Walker, J., Koulakoff, A., Franek, K.J., Qadri, F., Giaume, C., Corvol, P., Schwartz, C.E. and Nguyen, G.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 297 (2): R250-R257. August 2009

Growth arrest specific protein 6 participates in DOCA-induced target-organ damage.
Park, J.K., Theuer, S., Kirsch, T., Lindschau, C., Klinge, U., Heuser, A., Plehm, R., Todiras, M., Carmeliet, P., Haller, H., Luft, F.C., Mueller, D.N. and Fiebeler, A.
Hypertension 54 (2): 359-364. August 2009

Human ovarian tissue vitrification versus conventional freezing: morphological, endocrinological, and molecular biological evaluation.
Isachenko, V., Lapidus, I., Isachenko, E., Krivokharchenko, A., Kreienberg, R., Woriedh, M., Bader, M. and Weiss, J.
Reproduction 138 (2): 319-327. August 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M., Steinman, L., Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).
Duerschmied, D., Canault, M., Lievens, D., Brill, A., Cifuni, S.M., Bader, M. and Wagner, D.D.
Journal of Thrombosis and Haemostasis 7 (7): 1163-1171. July 2009

Growth retardation and altered autonomic control in mice lacking brain serotonin.
Alenina, N., Kikic, D., Todiras, M., Mosienko, V., Qadri, F., Plehm, R., Boye, P., Vilianovitch, L., Sohr, R., Tenner, K., Hoertnagl, H. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 106 (25): 10332-10337. 23 June 2009

Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.
Kahn, R., Hellmark, T., Leeb-Lundberg, L.M., Akbari, N., Todiras, M., Olofsson, T., Wieslander, J., Christensson, A., Westman, K., Bader, M., Mueller-Esterl, W. and Karpman, D.
Journal of Immunology 182 (12): 7906-7915. 15 June 2009

Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119 (22): 2904-2912. 9 June 2009

Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria.
Pinheiro, S.V., Ferreira, A.J., Kitten, G.T., da Silveira, K.D., da Silva, D.A., Santos, S.H., Gava, E., Castro, C.H., Magalhaes, J.A., da Mota, R.K., Botelho-Santos, G.A., Bader, M., Alenina, N., Santos, R.A. and Simoes E Silva, A.C.
Kidney International 75 (11): 1184-1193. 1 June 2009

CENTB5 gene expression in human and mouse.
Shubina, D.M., Suchkova, I.O., Slominskaya, N.A., Alenina, N., Bader, M. and Patkin, E.L.
Molecular Biology 43 (3): 374-380. June 2009

Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy.
Westermann, D., Walther, T., Savvatis, K., Sobirey, M., Riad, A., Bader, M., Schultheiss, H.P. and Tschoepe, C.
Diabetes 58 (6): 1373-1381. June 2009

Kallikrein-kinin system in neovascularization.
Bader, M.
Arteriosclerosis Thrombosis and Vascular Biology 29 (5): 617-619. May 2009

The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats.
Leal, M.C., Pinheiro, S.V., Ferreira, A.J., Santos, R.A., Bordoni, L.S., Alenina, N., Bader, M. and Franca, L.R.
Journal of Anatomy 214 (5): 736-743. May 2009

Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown.
Kotnik, K., Popova, E., Todiras, M., Mori, M.A., Alenina, N., Seibler, J. and Bader, M.
PLoS ONE 4 (4): e5124. 2 April 2009

Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells.
Ladhoff, J., Bader, M., Broesel, S., Effenberger, E., Westermann, D., Volk, H.D. and Seifert, M.
Cell Research 19 (4): 507-518. April 2009

Role of bradykinin and catecholamines in cerebral infarction and brain edema - Response.
Kleinschnitz, C., Austinat, M., Stoll, G., Bader, M. and Renne, T.
Stroke 40 (4): e104. April 2009

Energy metabolism in human renin-gene transgenic rats. Does renin contribute to obesity?
Gratze, P., Boschmann, M., Dechend, R., Qadri, F., Malchow, J., Graeske, S., Engeli, S., Janke, J., Springer, J., Contrepas, A., Plehm, R., Klaus, S., Nguyen, G., Luft, F.C. and Mueller, D.N.
Hypertension 53 (3): 516-523. March 2009

The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice.
Xu, J., Carretero, O.A., Shesely, E.G., Rhaleb, N.E., Yang, J.J., Bader, M. and Yang, X.P.
Experimental Physiology 94 (3): 322-329. March 2009

Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol.
Wendt, N., Schulz, A., Qadri, F., Bolbrinker, J., Kossmehl, P., Winkler, K., Stoll, M., Vetter, R. and Kreutz, R.
Cardiovascular Research 81 (3): 618-626. 15 February 2009

Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction.
da Costa Goncalves, A.C., Tank, J., Diedrich, A., Hilzendeger, A., Plehm, R., Bader, M., Luft, F.C., Jordan, J. and Gross, V.
Hypertension 53 (2): 387-392. February 2009

Efficient production of nuclear transferred rat embryos by modified methods of reconstruction.
Popova, E., Bader, M. and Krivokharchenko, A.
Molecular Reproduction and Development 76 (2): 208-216. February 2009

The bradykinin B2 receptor in the early immune response against Listeria infection.
Kaman, W.E., Wolterink, A.F., Bader, M., Boele, L.C. and van der Kleij, D.
Medical Microbiology and Immunology 198 (1): 39-46. February 2009

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying Acromesomelic Dysplasia type Maroteaux.
Hume, A.N., Buttgereit, J., Al-Awadhi, A.M., Al-Suwaidi, S.S., John, A., Bader, M., Seabra, M.C., Al-Gazali, L. and Ali, B.R.
Human Molecular Genetics 18 (2): 267-277. 15 January 2009

The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: Preclinical evidence for the treatment of skin inflammation.
Pietrovski, E.F., Otuki, M.F., Regoli, D., Bader, M., Pesquero, J.B., Cabrini, D.A. and Zampronio, A.R.
Regulatory Peptides 152 (1-3): 67-72. 8 January 2009

Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema.
Austinat, M., Braeuninger, S., Pesquero, J.B., Brede, M., Bader, M., Stoll, G., Renne, T. and Kleinschnitz, C.
Stroke 40 (1): 285-293. January 2009

Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy.
Klein, J., Gonzalez, J., Duchene, J., Esposito, L., Pradere, J.P., Neau, E., Delage, C., Calise, D., Ahluwalia, A., Carayon, P., Pesquero, J.B., Bader, M., Schanstra, J.P. and Bascands, J.L.
FASEB Journal 23 (1): 134-142. January 2009

Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen gene.
Xu, P., Wang, Y., Sterner-Kock, A., Bader, M., Schultheiss, H.P. and Walther, T.
Journal of Cardiovascular Pharmacology 53 (1): 38-43. January 2009

Highlights of the 13th Annual Meeting of the European Council for Cardiovascular Research. 13th Annual Meeting of the European Council for Cardiovascular Research (ECCR). Nice, France, 10-12 October, 2008.
Bader, M.
Future Cardiology 5 (1): 23-25. January 2009

2008

Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats.
Upadhyay, S., Stoeger, T., Harder, V., Thomas, R.F., Schladweiler, M.C., Semmler-Behnke, M., Takenaka, S., Karg, E., Reitmeir, P., Bader, M., Stampfl, A., Kodavanti, U.P. and Schulz, H.
Particle and Fibre Toxicology 5 (1): 19. 4 December 2008

Variations in DSG2: V56M, V158G and V920G are not pathogenic for arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Posch, M.G., Posch, M.J., Perrot, A., Dietz, R. and Oezcelik, C.
Nature Clinical Practice Cardiovascular Medicine 5 (12): E1. December 2008

Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart.
Mercure, C., Yogi, A., Callera, G.E., Aranha, A.B., Bader, M., Ferreira, A.J., Santos, R.A., Walther, T., Touyz, R.M. and Reudelhuber, T.L.
Circulation Research 103 (11): 1319-1326. 21 November 2008

Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice.
Dos Santos, A.C., Roffe, E., Arantes, R.M., Juliano, L., Pesquero, J.L., Pesquero, J.B., Bader, M., Teixeira, M.M. and Carvalho-Tavares, J.
Journal of Neuroinflammation 5 (1): 49. 5 November 2008

Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction.
Rabelo, L.A., Xu, P., Todiras, M., Sampaio, W.O., Buttgereit, J., Bader, M., Santos, R.A. and Alenina, N.
Journal of the American Society of Hypertension 2 (6): 418-424. November 2008

Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.
Rentzsch, B., Todiras, M., Iliescu, R., Popova, E., Campos, L.A., Oliveira, M.L., Baltatu, O.C., Santos, R.A. and Bader, M.
Hypertension 52 (5): 967-973. November 2008

Generation and characterization of a GFP transgenic rat line for embryological research.
Popova, E., Rentzsch, B., Bader, M. and Krivokharchenko, A.
Transgenic Research 17 (5): 955-963. October 2008

Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation.
da Costa-Goncalves, A.C., Tank, J., Plehm, R., Diedrich, A., Todiras, M., Gollasch, M., Heuser, A., Wellner, M., Bader, M., Jordan, J., Luft, F.C. and Gross, V.
Hypertension 52 (4): 702-707. October 2008

Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Xi, L., Das, A., Zhao, Z.Q., Merino, V.F., Bader, M. and Kukreja, R.C.
Circulation 118 (14 Suppl): S32-S37. 30 September 2008

Cardiovascular hormone systems.
Bader, M., ed.
Wiley-Blackwell, 1-433. ISBN 9783527319206 10 September 2008

Kinins.
Macedo de Oliveira, S., de Picoli Souza, K., Bader, M. and Pesquero, J.B.
In: Cardiovascular Hormone Systems. Wiley-Blackwell, 101-123. ISBN 9783527319206 10 September 2008

Preface.
Bader, M.
Cardiovascular Hormone Systems : xvii-xviii. 10 September 2008

Serotonin.
Bader, M.
In: Cardiovascular Hormone Systems. Wiley-Blackwell, 209-231. ISBN 9783527319206 10 September 2008

Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes.
Dias-Peixoto, M.F., Santos, R.A., Gomes, E.R., Alves, M.N., Almeida, P.W., Greco, L., Rosa, M., Fauler, B., Bader, M., Alenina, N. and Guatimosim, S.
Hypertension 52 (3): 542-548. September 2008

Production of reconstructed two-cell rat embryos after chemical inactivation of chromosomes in MII oocytes by etoposide.
Zaitseva, Y.A., Bader, M. and Krivokharchenko, A.S.
Russian Journal of Developmental Biology 39 (5): 275-278. September 2008

Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats.
Nadu, A.P., Ferreira, A.J., Reudelhuber, T.L., Bader, M. and Santos, R.A.
Journal of the American Society of Hypertension 2 (5): 341-348. September 2008

Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.
Nocito, A., Dahm, F., Jochum, W., Jang, J.H., Georgiev, P., Bader, M., Graf, R. and Clavien, P.A.
Cancer Research 68 (13): 5152-5158. 1 July 2008