Angiotensin-(1-7) mediated calcium signalling by MAS

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Item Type:	Article
Title:	Angiotensin-(1-7) mediated calcium signalling by MAS
Creators:	Sureshkumar, P., Souza dos Santos, R.A. ORCID: https://orcid.org/0000-0001-8738-5852, Alenina, N. ORCID: https://orcid.org/0000-0002-6071-5433, Mergler, S. and Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164
Abstract:	The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1-7). It is a promising drug target since the Ang-(1-7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling is important for developing novel therapeutics for cardiovascular diseases. In this paper, we show that Ang-(1-7) increases intracellular calcium in transiently MAS-transfected HEK293 cells. The calcium influx induced by the activation of MAS is dependent on plasma membrane Ca(2+) channels, phospholipase C, and protein kinase C. Specifically, we could demonstrate that MAS employs non-selective, transient receptor potential channels (TRPs) for calcium entry.
Keywords:	Angiotensin, Calcium, MAS, Trp Channel
Source:	Peptides
ISSN:	0196-9781
Publisher:	Elsevier
Volume:	165
Page Range:	171010
Date:	July 2023
Official Publication:	https://doi.org/10.1016/j.peptides.2023.171010
PubMed:	View item in PubMed

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