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| Item Type: | Preprint |
|---|---|
| Title: | The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function |
| Creators: |
Dueck, A.  ORCID: https://orcid.org/0000-0002-7956-6327, Althaus, L., Heise, K., Esfandyari, D., Baygün, S., Brandes, R.P., Gagneur, J. ORCID: https://orcid.org/0000-0002-8924-8365, Jaé, N., Knolle, P., Leisegang, M.S. ORCID: https://orcid.org/0000-0003-3692-7142, Maegdefessel, L., Meitinger, T. ORCID: https://orcid.org/0000-0002-8838-8403, Niessing, D., Petzold, N., Ramanujam, D., Sager, H., Schulz, C., Theodorakis, E., Uzonyi, A., Weinberger, T., Wittig, I., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Schmidt-Supprian, M. and Engelhardt, S.
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| Abstract: | Cardiac resident macrophages (crMPs) were recently shown to exert pivotal functions in cardiac homeostasis and disease, but the underlying molecular mechanisms are largely unclear. Long non-coding RNAs (lncRNAs) are increasingly recognized as important regulatory molecules in a number of cell types, but neither the identity nor the molecular mechanisms of lncRNAs in crMPs are known. Here, we have employed deep RNA-seq and single cell RNA sequencing to resolve the crMP lncRNA landscape from healthy and diseased murine myocardium. CrMPs express previously unknown and highly cell type-specific lncRNAs, among which one lncRNA, termed Schlafenlnc, was particularly abundant and enriched in crMPs. We found Schlafenlnc to be necessary for migration-associated gene expression in macrophages in vitro and in vivo and essential for their adhesion and migration. Collectively, our data provide a basis to the systematic characterization of lncRNAs in crMPs and establish Schlafenlnc as a critical regulator of macrophage migratory functions. |
| Keywords: | Long Non-Coding RNA, Cardiac Resident Macrophages, Pressure Overload, SchlafenInc, Single Cell Sequencing, Animals, Mice |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2022.11.30.518576v3 |
| Date: | 2 October 2025 |
| Official Publication: | https://doi.org/10.1101/2022.11.30.518576 |
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