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Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction

Item Type:Review
Title:Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction
Creators Name:Filip, M., Alenina, N., Bader, M. and Przegalinski, E.
Abstract:Cocaine addiction has somatic, psychological, psychiatric, socio-economic and legal implications in the developed world. Presently, there is no medication approved for the treatment of cocaine addiction. In recent years, data from the literature (pre-clinical studies and clinical trials) have provided several lines of evidence that serotonin (5-HT) and 5-HT receptors play a modulatory role in the mechanisms of action of cocaine. Here we review the contribution of 5-HT receptor subtypes to cocaine sensitization, discrimination, conditioned place preference, self-administration, reinstatement of seeking behavior and withdrawal symptoms in laboratory animals. Additionally, the consequences of chronic cocaine exposure on particular 5-HT receptor-assigned functions in pre-clinical studies are presented.
Keywords:5-HT Receptors, Cocaine, Conditioned Place Preference, Discrimination, Reinstatement of Seeking Behavior, Sensitization, Self-Administration, Withdrawal, Animals, Rats
Source:Addiction Biology
Page Range:227-249
Date:July 2010
Official Publication:https://doi.org/10.1111/j.1369-1600.2010.00214.x
PubMed:View item in PubMed

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