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Regulation of the kinin receptors after induction of myocardial infarction: a mini-review

Item Type:Article
Title:Regulation of the kinin receptors after induction of myocardial infarction: a mini-review
Creators Name:Tschoepe, C., Heringer-Walther, S. and Walther, T.
Abstract:It is well known that the responses to vasoactive kinin peptides are mediated through the activation of two receptors termed bradykinin receptor B1(B1R) and B2 (B2R). The physiologically prominent B2R subtype has certainly been the subject of more intensive efforts in structure-function studies and physiological investigations. However, the B1R activated by a class of kinin metabolites has emerged as an important subject of investigation within the study of the kallikreinkinin system (KKS). Its inducible character under stress and tissue injury is therefore a field of major interest. Although the KKS has been associated with cardiovascular regulation since its discovery at the beginning of the last century, less is known about the B1R and B2R regulation in cardiovascular diseases like hypertension, myocardial infarction (MI) and their complications. This mini-review will summarize our findings on B1R and B2R regulation after induction of MI using a rat model. We will develop the hypothesis that differences in the expression of these receptors may be associated with a dual pathway of the KKS in the complex mechanisms of myocardial remodeling.
Keywords:B1 Receptor, B2 Receptor, Bradykinin, Heart Infarction, Kallikrein-Kinin System
Source:Brazilian Journal of Medical and Biological Research
Publisher:Associacao Brasileira De Divulgacao Cientifica
Page Range:701-708
Date:1 June 2000
Official Publication:https://doi.org/10.1590/S0100-879X2000000600011
PubMed:View item in PubMed

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