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Improved lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7)

Item Type:Article
Title:Improved lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7)
Creators Name:Santos, S.H., Felix Braga, J., Mario, E.G., Porto, L.C., Rodrigues-Machado, M.D., Murari, A., Botion, L.M., Alenina, N., Bader, M. and Santos, R.A.
Abstract:OBJECTIVE: Obesity and diabetes remain among the world's most pervasive health problems. Although the importance of angiotensin II for metabolic regulation is well documented, the role of the angiotensin-(1-7)/Mas axis in this process is poorly understood. The aim of this study was to evaluate the effect of increased angiotensin-(1-7) plasma levels in lipid and glucose metabolism using transgenic rats that express an angiotensin-(1-7)-releasing fusion protein, TGR(A1-7)3292 (TGR). METHODS AND RESULTS: The increased angiotensin-(1-7) levels in TGR induced enhanced glucose tolerance, insulin sensitivity, and insulin-stimulated glucose uptake. In addition, TGR rats presented decreased triglycerides and cholesterol levels, as well as a significant decrease in abdominal fat mass, despite normal food intake. These alterations were accompanied by a marked decrease of angiotensinogen expression and increased Akt in adipose tissue. Furthermore, augmented plasma levels and expression in adipose tissue was observed for adiponectin. Accordingly, angiotensin-(1-7) stimulation increased adiponectin production by primary adipocyte culture, which was blocked by the Mas antagonist A779. Circulating insulin and muscle glycogen content were not altered in TGR. CONCLUSIONS: These results show that increased circulating angiotensin-(1-7) levels lead to prominent changes in glucose and lipid metabolism.
Keywords:Angiotensin-(1-7) Mas Axis, Glucose Metabolism, Adipose Tissue, Cholesterol, Triglycerides, Adiponectin, Animals, Rats
Source:Arteriosclerosis Thrombosis and Vascular Biology
Publisher:American Heart Association
Page Range:953-61
Date:May 2010
Official Publication:https://doi.org/10.1161/ATVBAHA.109.200493
PubMed:View item in PubMed

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