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| Item Type: | Article |
|---|---|
| Title: | Vitamin D depletion aggravates hypertension and target-organ damage |
| Creators: |
Andersen, L.B.  ORCID: https://orcid.org/0000-0002-3331-7149, Przybyl, L. ORCID: https://orcid.org/0000-0001-9777-8879, Haase, N. ORCID: https://orcid.org/0000-0003-0727-1738, von Versen-Höynck, F., Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Jørgensen, J.S., Sorensen, G.L., Fruekilde, P., Poglitsch, M., Szijártó, I. ORCID: https://orcid.org/0000-0002-0796-9450, Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934, Peters, J., Muller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Christesen, H.T. and Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080
|
| Abstract: | BACKGROUND: We tested the controversial hypothesis that vitamin D depletion aggravates hypertension and target-organ damage by influencing renin. METHODS AND RESULTS: Four-week-old double-transgenic rats (dTGR) with excess angiotensin (Ang) II production due to overexpression of the human renin (hREN) and angiotensinogen (hAGT) genes received vitamin D-depleted (n=18) or standard chow (n=15) for 3 weeks. The depleted group had very low serum 25-hydroxyvitamin D levels (mean+/-SEM; 3.8+/-0.29 versus 40.6+/-1.19 nmol/L) and had higher mean systolic BP at week 5 (158+/-3.5 versus 134.6+/-3.7 mm Hg, P<0.001), week 6 (176.6+/-3.3 versus 162.3+/-3.8 mm Hg, P<0.01), and week 7 (171.6+/-5.1 versus 155.9+/-4.3 mm Hg, P<0.05). Vitamin D depletion led to increased relative heart weights and increased serum creatinine concentrations. Furthermore, the mRNAs of natriuretic peptides, neutrophil gelatinase-associated lipocalin, hREN, and rRen were increased by vitamin D depletion. Regulatory T cells in the spleen and in the circulation were not affected. Ang metabolites, including Ang II and the counter-regulatory breakdown product Ang 1 to 7, were significantly up-regulated in the vitamin D-depleted groups, while ACE-1 and ACE-2 activities were not affected. CONCLUSIONS: Short-term severe vitamin D depletion aggravated hypertension and target-organ damage in dTGR. Our data suggest that even short-term severe vitamin D deficiency may directly promote hypertension and impacts on renin-angiotensin system components that could contribute to target-organ damage. The findings add to the evidence that vitamin D deficiency could also affect human hypertension. |
| Keywords: | Hypertension, Renin, Vitamin D, Animals, Rats |
| Source: | Journal of the American Heart Association |
| ISSN: | 2047-9980 |
| Publisher: | Wiley-Blackwell |
| Volume: | 4 |
| Number: | 2 |
| Page Range: | e001417 |
| Date: | February 2015 |
| Official Publication: | https://doi.org/10.1161/JAHA.114.001417 |
| PubMed: | View item in PubMed |
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