Items where Year is 2022

Article

Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis.
Abdelhak, A., Cordano, C., Boscardin, W.J., Caverzasi, E., Kuhle, J., Chan, B., Gelfand, J.M., Yiu, H.H., Oertel, F.C., Beaudry-Richard, A., Condor Montes, S., Oksenberg, J.R., Lario Lago, A., Boxer, A., Rojas-Martinez, J.C., Elahi, F.M., Chan, J.R. and Green, A.J.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 972-977. 12 August 2022

Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.
Abdelhak, A., Solomon, I., Montes, S.C., Saias, A., Cordano, C., Asken, B., Fonseca, C., Oertel, F.C., Arfanakis, K., Staffaroni, A.M., Kramer, J.H., Geschwind, M., Miller, B.L., Elahi, F.M. and Green, A.J.
Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring 14 (1): e12338. 2022

HDHL-INTIMIC: a European knowledge platform on food, diet, intestinal microbiomics, and human health.
Agamennone, V., Abuja, P.M., Basic, M., De Angelis, M., Gessner, A., Keijser, B., Larsen, M., Pinart, M., Nimptsch, K., Pujos-Guillot, E., Schlicht, K., Sharon, I., Untersmayr, E., Laudes, M., Pischon, T. and Bouwman, J.
Nutrients 14 (9): 1881. 29 April 2022

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4(+) T cells and is defective in Crohn's disease patients.
Ahlers, J., Mantei, A., Lozza, L., Stäber, M., Heinrich, F., Bacher, P., Hohnstein, T., Menzel, L., Yüz, S.G., Alvarez-Simon, D., Bickenbach, A.R., Weidinger, C., Mockel-Tenbrinck, N., Kühl, A.A., Siegmund, B., Maul, J., Neumann, C. and Scheffold, A.
Mucosal Immunology 15 (3): 480-490. May 2022

Midwall fibrosis and cardiac mechanics: rigid body rotation is a novel marker of disease severity in pediatric primary dilated cardiomyopathy.
Al-Wakeel-Marquard, N., Seidel, F., Kühnisch, J., Kuehne, T., Berger, F., Messroghli, D.R. and Klaassen, S.
Frontiers in Cardiovascular Medicine 8 : 810005. 17 February 2022

Angiotensin 1-7 increases fiber cross sectional area and force in juvenile mouse skeletal muscle.
Albadrani, H., Ammar, T., Rajgara, R., Bader, M., Wiper-Bergeron, N. and Renaud, J.M.
American Journal of Physiology Cell Physiology 323 (6): C1681-C1696. December 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H., Flórez, A.F., Kreth, S., Brückner, L.M., Yildiz, U., Gartlgruber, M., Odoni, D.I., Poschet, G., Garbowicz, K., Shao, C., Klein, C., Meier, J., Zeisberger, P., Nadler-Holly, M., Ziehm, M., Paul, F., Burhenne, J., Bell, E., Shaikhkarami, M., Würth, R., Stainczyk, S.A., Wecht, E.M., Kreth, J., Büttner, M., Ishaque, N., Schlesner, M., Nicke, B., Stresemann, C., Llamazares-Prada, M., Reiling, J.H., Fischer, M., Amit, I., Selbach, M., Herrmann, C., Wölfl, S., Henrich, K.O., Höfer, T., Trumpp, A. and Westermann, F.
Nature Cancer 3 (4): 471-485. 28 April 2022

Lifting the veil of secrecy: maternal and neonatal outcome of oocyte donation pregnancies in Germany.
Altmann, J., Kummer, J., Herse, F., Hellmeyer, L., Schlembach, D., Henrich, W. and Weichert, A.
Archives of Gynecology and Obstetrics 306 (1): 59-69. July 2022

Acute myocarditis associated with desmosomal gene variants.
Ammirati, E., Raimondi, F., Piriou, N., Sardo Infirri, L., Mohiddin, S.A., Mazzanti, A., Shenoy, C., Cavallari, U.A., Imazio, M., Aquaro, G.D., Olivotto, I., Pedrotti, P., Sekhri, N., Van de Heyning, C.M., Broeckx, G., Peretto, G., Guttmann, O., Dellegrottaglie, S., Scatteia, A., Gentile, P., Merlo, M., Goldberg, R.I., Reyentovich, A., Sciamanna, C., Klaassen, S., Poller, W., Trankle, C.R., Abbate, A., Keren, A., Horowitz-Cederboim, S., Cadrin-Tourigny, J., Tadros, R., Annoni, G.A., Bonoldi, E., Toquet, C., Marteau, L., Probst, V., Trochu, J.N., Kissopoulou, A., Grosu, A., Kukavica, D., Trancuccio, A., Gil, C., Tini, G., Pedrazzini, M., Torchio, M., Sinagra, G., Gimeno, J.R., Bernasconi, D., Valsecchi, M.G., Klingel, K., Adler, E.D., Camici, P.G. and Cooper, L.T.
JACC Heart Fail 10 (10): 714-727. October 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C., Acemel, R.D., Jedamzick, J., Bolondi, A., Cova, G., Brieske, N., Kühn, R., Wittler, L., Real, F.M. and Lupiáñez, D.G.
Nature Genetics 54 (7): 1026-1036. July 2022

Different impact of gadopentetate and gadobutrol on inflammation-promoted retention and toxicity of gadolinium within the mouse brain.
Anderhalten, L., Silva, R.V., Morr, A., Wang, S., Smorodchenko, A., Saatz, J., Traub, H., Mueller, S., Boehm-Sturm, P., Rodriguez-Sillke, Y., Kunkel, D., Hahndorf, J., Paul, F., Taupitz, M., Sack, I. and Infante-Duarte, C.
Investigative Radiology 57 (10): 677-688. 1 October 2022

De novo whole genome assembly of the Roborovski dwarf hamster (Phodopus roborovskii) genome, an animal model for severe/critical COVID-19.
Andreotti, S., Altmüller, J., Quedenau, C., Borodina, T., Nouailles, G., Teixeira Alves, L.G., Landthaler, M., Bieniara, M., Trimpert, J. and Wyler, E.
Genome Biology and Evolution 14 (7): evac100. July 2022

Downregulation of odd-skipped related 2, a novel regulator of epithelial-mesenchymal transition, enables efficient somatic cell reprogramming.
Anh, L.P.H., Nishimura, K., Kuno, A., Nguyen, T.L., Kato, T., Ohtaka, M., Nakanishi, M., Sugihara, E., Sato, T.A., Hayashi, Y., Fukuda, A. and Hisatake, K.
Stem Cells 40 (4): 397-410. 29 April 2022

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.
Ansari, S.A., Dantoft, W., Ruiz-Orera, J., Syed, A.P., Blachut, S., van Heesch, S., Hübner, N. and Uhlenhaut, N.H.
Computational and Structural Biotechnology Journal 20 : 5622-5638. 3 October 2022

Prognostic value of stress cardiac magnetic resonance in patients with known coronary artery disease.
Antiochos, P., Ge, Y., Heydari, B., Steel, K., Bingham, S., Abdullah, S.M., Mikolich, J.R., Arai, A.E., Bandettini, W.P., Patel, A.R., Farzaneh-Far, A., Heitner, J.F., Shenoy, C., Leung, S.W., Gonzalez, J.A., Shah, D.J., Raman, S.V., Ferrari, V.A., Schulz-Menger, J., Stuber, M., Simonetti, O.P. and Kwong, R.Y.
JACC: Cardiovascular Imaging 15 (1): 60-71. January 2022

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M.J. and Bock, A.
Cell 185 (7): 1130-1142.e11. 31 March 2022

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visually triggered locomotive enhancement in mice upon optogenetic stimulation.
Araragi, N., Alenina, N. and Bader, M.
Heliyon 8 (1): e08692. January 2022

Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial.
Arends, C.M., Dimitriou, S., Stahler, A., Hablesreiter, R., Strzelecka, P.M., Stein, C.M., Tilgner, M., Saiki, R., Ogawa, S., Bullinger, L., Modest, D.P., Stintzing, S., Heinemann, V. and Damm, F.
Blood 139 (10): 1593-1597. 10 March 2022

Immunohistochemical analysis of nicotinamide phosphoribosyltransferase expression in gastric and esophageal adenocarcinoma (AEG).
Arnold, A., von Winterfeld, M., Berg, E., Hummel, M., Rau, B., Krenzien, F., Stein, U. and Treese, C.
Gastrointestinal Disorders 4 (4): 333-340. 13 December 2022

Kinin B1 receptor modulates mitochondrial activity responsivity in fasting and voluntary exercise.
Arruda, A.C., Budu, A., de Menezes, T.N., Bader, M., Araujo, R.C. and Freitas-Lima, L.C.
Life Sciences 309 : 121034. 15 November 2022

LABKIT: labeling and segmentation toolkit for big image data.
Arzt, M., Deschamps, J., Schmied, C., Pietzsch, T., Schmidt, D., Tomancak, P., Haase, R. and Jug, F.
Frontiers in Computer Science 4 : 777728. 10 February 2022

De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway.
Asif, M., Kaygusuz, E., Shinawi, M., Nickelsen, A., Hsieh, T.C., Wagle, P., Budde, B., Hochscherf, J., Abdullah, U., Höning, S., Nienberg, C., Lindenblatt, D., Noegel, A.A., Altmüller, J., Thiele, H., Motameny, S., Fleischer, N., Segal, I., Pais, L., Tinschert, S., Samra, N.G., Savatt, J.M., Rudy, N.L., De Luca, C., Fortugno, P., White, S.M., Krawitz, P., Hurst, A.C.E., Niefind, K., Jose, J., Brancati, F., Nürnberg, P. and Hussain, M.S.
Human Genetics and Genomics Advances 3 (3): 100111. 14 July 2022

A novel missense variant of SCN4A co-segregates with congenital essential tremor in a consanguineous Kurdish family.
Asif, M., Mocanu, I.D., Abdullah, U., Höhne, W., Altmüller, J., Makhdoom, E.U.H., Thiele, H., Baig, S.M., Nürnberg, P., Graul-Neumann, L. and Hussain, M.S.
American Journal of Medical Genetics A 188 (4): 1251-1258. April 2022

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja, A., Wakimoto, H., DeLaughter, D.M., Reichart, D., Gorham, J., Conner, D.A., Lun, M., Probst, C.K., Sakai, N., Knipe, R.S., Montesi, S.B., Shea, B., Adam, L.P., Leinwand, L.A., Wan, W., Choi, E.S., Lindberg, E.L., Patone, G., Noseda, M., Hübner, N., Seidman, C.E., Tager, A.M., Seidman, J.G. and Ho, C.Y.
Proceedings of the National Academy of Sciences of the United States of America 119 (28): e2204174119. 12 July 2022

Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders.
Ayadi, N., Oertel, F.C., Asseyer, S., Rust, R., Duchow, A., Kuchling, J., Bellmann-Strobl, J., Ruprecht, K., Klistorner, A., Brandt, A.U., Paul, F. and Zimmermann, H.G.
Multiple Sclerosis Journal 28 (5): 757-767. April 2022

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran, D., Kochlamazashvili, G., Pampaloni, N. P., Sposini, S., Shergill, J.K., Lehmann, M., Pashkova, N., Schmidt, C., Löwe, D., Napieczynska, H., Heuser, A., Plested, A.J.R., Perrais, D., Piper, R.C., Haucke, V. and Maritzen, T.
Science Advances 8 (21): eabl5032. 27 May 2022

A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions.
Babity, S., Couture, F., Campos, E.V.R., Hedtrich, S., Hagen, R., Fehr, D., Bonmarin, M. and Brambilla, D.
Advanced Healthcare Materials 11 (6): e2102070. March 2022

Anatomical and functional visual network patterns in progressive multiple sclerosis.
Backner, Y., Zamir, S., Petrou, P., Paul, F., Karussis, D. and Levin, N.
Human Brain Mapping 43 (5): 1590-1597. 1 April 2022

RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
Bahry, E., Breimann, L., Zouinkhi, M., Epstein, L., Kolyvanov, K., Mamrak, N., King, B., Long, Xi, Harrington, K.I.S., Lionnet, T. and Preibisch, S.
Nature Methods 19 (12): 1563-1567. December 2022

Microglia form satellites with different neuronal subtypes in the adult murine central nervous system.
Bakina, O., Kettenmann, H. and Nolte, C.
Journal of Neuroscience Research 100 (4): 1105-1122. April 2022

Unraveling the hidden temporal range of fast β(2)-adrenergic receptor mobility by time-resolved fluorescence.
Balakrishnan, A., Hemmen, K., Choudhury, S., Krohn, J.H., Jansen, K., Friedrich, M., Beliu, G., Sauer, M., Lohse, M.J. and Heinze, K.G.
Communications Biology 5 (1): 176. 28 February 2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Balasubramanian, S., Andreani, M., Goncalves Andrade, J., Saha, T., Sundaravinayagam, D., Garzón, J., Zhang, W., Popp, O., Hiraga, S., Rahjouei, A., Rosen, D.B., Mertins, P., Chait, B.T., Donaldson, A.D. and Di Virgilio, M.
eLife 11 : e75047. 13 April 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S., Bulatov, T., Schmied, C., Krämer, A., Berger, B.T., Oder, A., Walker-Gray, R., Kuschke, C., Zühlke, K., Eichhorst, J., Lehmann, M., Knapp, S., Weston, J., von Kries, J.P., Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.
Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C, Daub, C.O., Lenhard, B. and Müller, F.
Nature Genetics 54 (7): 1037-1050. July 2022

Multi-omics alleviates the limitations of panel sequencing for cancer drug response prediction.
Baranovskii, A., Gündüz, I.B., Franke, V., Uyar, B. and Akalin, A.
Cancers 14 (22): 5604. 15 November 2022

Transcriptome analysis reveals high tumor heterogeneity with respect to re-activation of stemness and proliferation programs.
Baranovsky, A., Ivanov, T., Granovskaya, M., Papatsenko, D. and Pervouchine, D.D.
PLoS ONE 17 (5): e0268626. 19 May 2022

PyZebraScope: an open-source platform for brain-wide neural activity imaging in zebrafish.
Barbara, R., Nagathihalli Kantharaju, M., Haruvi, R., Harrington, K. and Kawashima, T.
Frontiers in Cell and Developmental Biology 10 : 875044. 19 May 2022

Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells.
Basti, A., Malhan, D., Dumbani, M., Dahlmann, M., Stein, U. and Relógio, A.
Cancers 14 (14): 3458. 16 July 2022

Role of endothelial kinin B(1) receptor on the membrane potential of transgenic rat aorta.
Batista, C., Sales, V.M., Merino, V.F., Bader, M., Feres, T. and Pesquero, J.B.
Physiological Research 71 (4): 477-487. August 2022

Sexual dimorphism in extracellular matrix composition and viscoelasticity of the healthy and inflamed mouse brain.
Batzdorf, C.S., Morr, A.S., Bertalan, G., Sack, I., Silva, R.V. and Infante-Duarte, C.
Biology 11 (2): 230. 31 January 2022

State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt, M., Hülsemann, M., Löwa, A., Fatykhova, D., Hoffmann, K., Kessler, M., Mieth, M., Hellwig, K., Frey, D., Langenhagen, A., Voss, A., Obermayer, B., Wyler, E., Dökel, S., Gruber, A.D., Tölch, U., Hippenstiel, S., Hocke, A.C. and Hönzke, K.
PLoS ONE 17 (12): e0276115. 20 December 2022

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics.
Bayram, S., Razzaque, Y.S., Geisberger, S., Pietzke, M., Fürst, S., Vechiatto, C., Forbes, M., Mastrobuoni, G. and Kempa, S.
Frontiers in Molecular Biosciences 9 : 859787. 12 August 2022

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics.
Baytek, G., Blume, A., Demirel, F.G., Bulut, S., Popp, O., Mertins, P. and Tursun, B.
Biotechniques 73 (1): 5-17. June 2022

Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation.
Baytek, G., Popp, O., Mertins, P. and Tursun, B.
Biotechniques 72 (5): 175-184. May 2022

AQUA mutant protein quantification of endomyocardial biopsy-sized samples from a patient with hypertrophic cardiomyopathy.
Becker, E., Francino, A., Pich, A., Perrot, A., Kraft, T. and Radocaj, A.
Frontiers in Cardiovascular Medicine 9 : 816330. 21 February 2022

Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified clostridium perfringens enterotoxin (CPE).
Beier, L.S., Piontek, J., Piontek, A., Protze, J., Kobelt, D. and Walther, W.
Methods in Molecular Biology 2521 (3): 173-188. 23 June 2022

Human primary muscle stem cells regenerate injured urethral sphincter in athymic rats.
Bekele, B.M., Schöwel-Wolf, V., Kieshauer, J., Marg, A., Busjahn, A., Davis, S., Nugent, G., Ebert, A.K. and Spuler, S.
Animal Models and Experimental Medicine 5 (5): 453-460. October 2022

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K.E., Prifiti, E., Aron-Wisnewsky, J., Debédat, J., Le Roy, T., Nielsen, T., Amouyal, C., André, S., Andreelli, F., Blüher, M., Chakaroun, R., Chilloux, J., Coelho, L.P., Dao, M.C., Das, P., Fellahi, S., Forslund, S., Galleron, N., Hansen, T.H., Holmes, B., Ji, B., Krogh Pedersen, H., Le, P., Le Chatelier, E., Lewinter, C., Mannerås-Holm, L., Marquet, F., Myridakis, A., Pelloux, V., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Sokolovska, N., Søndertoft, N.B., Touch, S., Vieira-Silva, S., Galan, P., Holst, J., Gøtze, J.P., Køber, L., Vestergaard, H., Hansen, T., Hercberg, S., Oppert, J.M., Nielsen, J., Letunic, I., Dumas, M.E., Stumvoll, M., Pedersen, O.B., Bork, P., Ehrlich, S.D., Zucker, J.D., Bäckhed, F., Raes, J. and Clément, K.
Gut 71 (12): 2463-2480. 7 November 2022

Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines.
Benaglio, P., Zhu, H., Okino, M.L., Yan, J., Elgamal, R., Nariai, N., Beebe, E., Korgaonkar, K., Qiu, Y., Donovan, M.K.R., Chiou, J., Wang, G., Newsome, J., Kaur, J., Miller, M., Preissl, S., Corban, S., Aylward, A., Taipale, J., Ren, B., Frazer, K.A., Sander, M. and Gaulton, K.J.
Cell Genomics 2 (12): 100214. 14 December 2022

Association between B-cell depletion and attack risk in neuromyelitis optica spectrum disorder: An exploratory analysis from N-MOmentum, a double-blind, randomised, placebo-controlled, multicentre phase 2/3 trial.
Bennett, J.L., Aktas, O., Rees, W.A., Smith, M.A., Gunsior, M., Yan, L., She, D., Cimbora, D., Pittock, S.J., Weinshenker, B.G., Paul, F., Marignier, R., Wingerchuk, D., Cutter, G., Green, A., Hartung, H.P., Kim, H.J., Fujihara, K., Levy, M., Katz, E. and Cree, B.A.C.
EBioMedicine 86 : 104321. December 2022

Electrocardiographic changes during initiation of lithium augmentation of antidepressant pharmacotherapy.
Berger, M., Kermer, J., Behr, J., Schulz-Menger, J., Bilal, S., Osterland, S.L., O'Malley, G., Bschor, T., Schlattmann, P., Stamm, T., Steinacher, B., de Millas, W., Richter, C., Heinz, A., Adli, M., Buspavanich, P. and Ricken, R.
Journal of Clinical Psychopharmacology 42 (1): 87-91. January 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M., Tucker, E., Dorel, M., Winkler, A., McGearey, A., Rodriguez-Fos, E., da Costa, B.M., Barker, K., Fyle, E., Calton, E., Eising, S., Ober, K., Hughes, D., Koutroumanidou, E., Carter, P., Stankunaite, R., Proszek, P., Jain, N., Rosswog, C., Dorado-Garcia, H., Molenaar, J.J., Hubank, M., Barone, G., Anderson, J., Lang, P., Deubzer, H.E., Künkele, A., Fischer, M., Eggert, A., Kloft, C., Henssen, A.G., Boettcher, M., Hertwig, F., Blüthgen, N., Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

Impact of the external school food environment on the associations of internal school food environment with high schoolers’ diet and BMI.
Betts, G.M., Schwedhelm, C., Lipsky, L.M., Haynie, D.L. and Nansel, T.R.
Public Health Nutrition 25 (11): 3086-3095. November 2022

Elevated blood pressure in pregnant women with gestational diabetes according to the WHO criteria: importance of overweight.
Birukov, A., Glintborg, D., Schulze, M.B., Jensen, T.K., Kuxhaus, O., Andersen, L.B., Kräker, K., Polemiti, E., Jensen, B.L., Jørgensen, J.S., Dechend, R. and Andersen, M.S.
Journal of Hypertension 40 (8): 1614-1623. August 2022

The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff, P., Trinks, A., Wiederspahn, J., Obermayer, B., Pett, J.P., Jurmeister, P., Elsner, A., Dziodzio, T., Rückert, J.C., Neudecker, J., Falk, C., Beule, D., Sers, C., Morkel, M., Horst, D., Klauschen, F. and Blüthgen, N.
International Journal of Cancer 150 (12): 2058-2071. 15 June 2022

Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma.
Bishop, M.R., Dickinson, M., Purtill, D., Barba, P., Santoro, A., Hamad, N., Kato, K., Sureda, A., Greil, R., Thieblemont, C., Morschhauser, F., Janz, M., Flinn, I., Rabitsch, W., Kwong, Y.L., Kersten, M.J, Minnema, M.C., Holte, H., Chan, E.H.L., Martinez-Lopez, J., Müller, A.M.S., Maziarz, R.T., McGuirk, J.P., Bachy, E., Le Gouill, S., Dreyling, M., Harigae, H., Bond, D., Andreadis, C., McSweeney, P., Kharfan-Dabaja, M., Newsome, S., Degtyarev, E., Awasthi, R., Del Corral, C., Andreola, G., Masood, A., Schuster, S.J., Jäger, U., Borchmann, P. and Westin, J.R.
New England Journal of Medicine 386 (7): 629-639. 17 February 2022

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation.
Blassberg, R., Patel, H., Watson, T., Gouti, M., Metzis, V., Delás, M.J. and Briscoe, J.
Nature Cell Biology 24 (5): 633-644. May 2022

Impact of dietary intervention on serum neurofilament light chain in multiple sclerosis.
Bock, M., Steffen, F., Zipp, F. and Bittner, S.
Neurology Neuroimmunology & Neuroinflammation 9 (1): e1102. January 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy.
Boeckel, J.N., Möbius-Winkler, M., Müller, M., Rebs, S., Eger, N., Schoppe, L., Tappu, R., Kokot, K.E., Kneuer, J.M., Gaul, S., Bordalo, D.M., Lai, A., Haas, J., Ghanbari, M., Drewe-Boss, P., Liss, M., Katus, H.A., Ohler, U., Gotthardt, M., Laufs, U., Streckfuss-Bömeke, K. and Meder, B.
Genomics Proteomics & Bioinformatics 20 (1): 129-146. February 2022

Lifelong effect of therapy in young patients with the cOL4A5 alport missense variant p.(Gly624Asp): a prospective cohort study.
Boeckhaus, J., Hoefele, J., Riedhammer, K.M., Nagel, M., Beck, B., Choi, M., Gollasch, M., Bergmann, C., Sonntag, J.E., Troesch, V., Stock, J. and Gross, O.
Nephrology Dialysis Transplantation 37 (12): 2496-2504. December 2022

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska, R., Mikecin, A.M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S.V., Asada, N., Rodriguez-Correa, E., Frauhammer, F., Buettner, F., Ball, M., Knoch, J., Stäble, S., Walter, D., Petri, A., Carreño-Gonzalez, M.J., Wagner, V., Brors, B., Haas, S., Lipka, D.B., Essers, M.A.G., Weru, V., Holland-Letz, T., Mallm, J.P., Rippe, K., Krämer, S., Schlesner, M., McKinney Freeman, S., Florian, M.C., King, K.Y., Frenette, P.S., Rieger, M.A. and Milsom, M.D.
Cell Stem Cell 29 (8): 1273-1284. 4 August 2022

Full-length spatial transcriptomics reveals the unexplored isoform diversity of the myocardium post-MI.
Boileau, E., Li, X., Naarmann-de Vries, I.S., Becker, C., Casper, R., Altmüller, J., Leuschner, F. and Dieterich, C.
Frontiers in Genetics 13 : 912572. 22 July 2022

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.
Boix, O., Martinez, M., Vidal, S., Giménez-Alejandre, M., Palenzuela, L., Lorenzo-Sanz, L., Quevedo, L., Moscoso, O., Ruiz-Orera, J., Ximénez-Embún, P., Ciriaco, N., Nuciforo, P., Stephan-Otto Attolini, C., Albà, M.M., Muñoz, J., Tian, T.V., Varela, I., Vivancos, A., Ramón Y Cajal, S., Muñoz, P., Rivas, C. and Abad, M.
Nature Communications 13 (1): 6840. 11 November 2022

The impact of membrane protein diffusion on GPCR signaling.
Boltz, H.H., Sirbu, A., Stelzer, N., de Lanerolle, P., Winkelmann, S. and Annibale, P.
Cells 11 (10): 1660. 17 May 2022

Examination of the contributions of maternal/placental-derived galectin-1 to pregnancy outcome.
Borowski, S., Freitag, N., Urban, I., Michel, G., Barrientos, G. and Blois, S.M.
Methods in Molecular Biology 2442 : 603-619. 2022

Association of cholinesterase activities and POD in older adult abdominal surgical patients.
Bosancic, Z., Spies, C.D., Müller, A., Winterer, G., Piper, S.K. and Heinrich, M.
BMC Anesthesiology 22 (1): 293. 16 September 2022

Glucose-induced hemodynamic and metabolic response of skeletal muscle in heart failure patients with reduced vs. preserved ejection fraction-a pilot study.
Boschmann, M., Klug, L., Edelmann, F., Sandek, A., von Haehling, S., Düngen, H.D., Springer, J., Anker, S.D., Doehner, W. and Jauert, N.
Journal of Cardiovascular Development and Disease 9 (12): 456. 13 December 2022

Conditioning with fludarabine and treosulfan compared to FLAMSA-RIC in allogeneic stem cell transplantation for myeloid malignancies: a retrospective single-center analysis.
Braitsch, K., Schwarz, A., Koch, K., Hubbuch, M., Menzel, H., Keller, U., Götze, K.S., Bassermann, F., Herhaus, P. and Verbeek, M.
Annals of Hematology 101 (6): 1311-1319. June 2022

Central stress processing, T-cell responsivity to stress hormones, and disease severity in multiple sclerosis.
Brasanac, J., Hetzer, S., Asseyer, S., Kuchling, J., Bellmann-Strobl, J., Ritter, K., Gamradt, S., Scheel, M., Haynes, J.D., Brandt, A.U., Paul, F., Gold, S.M. and Weygandt, M.
Brain Communications 4 (2): fcac086. 4 April 2022

Immune signature of multiple sclerosis-associated depression.
Brasanac, J., Ramien, C., Gamradt, S., Tänzer, A., Glau, L., Ritter, K., Patas, K., Agorastos, A., Wiedemann, K., Demiralay, C., Fischer, F., Otte, C., Bellmann-Strobl, J., Friese, M.A., Tolosa, E., Paul, F., Heesen, C., Weygandt, M. and Gold, S.M.
Brain Behavior and Immunity 100 : 174-182. February 2022

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways.
Braun, T., Glass, M., Wahnschaffe, L., Otte, M., Mayer, P., Franitza, M., Altmüller, J., Hallek, M., Hüttelmaier, S., Schrader, A. and Herling, M.
Haematologica 107 (1): 187-200. January 2022

Noncanonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia.
Braun, T., Stachelscheid, J., Bley, N., Oberbeck, S., Otte, M., Müller, T.A., Wahnschaffe, L., Glaß, M., Ommer, K., Franitza, M., Gathof, B., Altmüller, J., Hallek, M., Auguin, D., Hüttelmaier, S., Schrader, A. and Herling, M.
Cancer Research 82 (9): 1818-1831. 1 May 2022

Relapse of NPM1-mutated AML with extramedullary manifestation 17 years after allogeneic hematopoietic stem cell transplantation.
Braune, J., Rieger, K., Blau, O., Keller, U., Bullinger, L. and Krönke, J.
Case Reports in Hematology 2022 : 3317936. 28 December 2022

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
Brauneck, F., Fischer, B., Witt, M., Muschhammer, J., Oelrich, J., da Costa Avelar, P.H., Tsoka, S., Bullinger, L., Seubert, E., Smit, D.J., Bokemeyer, C., Ackermann, C., Wellbrock, J., Haag, F. and Fiedler, W.
Journal for ImmunoTherapy of Cancer 10 (12): e004794. 22 December 2022

Claudin-10a deficiency shifts proximal tubular Cl(-) permeability to cation selectivity via claudin-2 redistribution.
Breiderhoff, T., Himmerkus, N., Meoli, L., Fromm, A., Sewerin, S., Kriuchkova, N., Nagel, O., Ladilov, Y., Krug, S., Quintanova, C., Stumpp, M., Garbe-Schönberg, D., Westernströer, U., Merkel, C., Brinkhus, M., Altmüller, J., Schweiger, M., Mueller, D., Mutig, K., Morawski, M., Halbritter, J., Milatz, S., Bleich, M. and Günzel, D.
Journal of the American Society of Nephrology 33 (4): 699-717. April 2022

The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding.
Breimann, L., Morao, A.K., Kim, J., Jimenez, D.S., Maryn, N., Bikkasani, K., Carrozza, M.J., Albritton, S.E., Kramer, M., Street, L.A., Cerimi, K., Schumann, V.F., Bahry, E., Preibisch, S., Woehler, A. and Ercan, S.
Journal of Cell Science 135 (2): jcs258818. January 2022

Optimization of synthetic molecular reporters for a mesenchymal glioblastoma transcriptional program by integer programming.
Breitenbach, T., Schmitt, M.J. and Dandekar, T.
Bioinformatics 38 (17): 4162-4171. 1 September 2022

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto, M., Kaminski, M.M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A.J., Tan, X., Kim, H., Dighe, A.S., Collins, J.J. and Stevens, M.M.
Nature Nanotechnology 17 (10): 1120-1126. October 2022

Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis.
Brune, S., Høgestøl, E.A., de Rodez Benavent, S.A., Berg-Hansen, P., Beyer, M.K., Leikfoss, I.S., Bos, S.D., Sowa, P., Brunborg, C., Andorra, M., Pulido Valdeolivas, I., Asseyer, S., Brandt, A., Chien, C., Scheel, M., Blennow, K., Zetterberg, H., Kerlero de Rosbo, N., Paul, F., Uccelli, A., Villoslada, P., Berge, T. and Harbo, H.F.
Multiple Sclerosis Journal 28 (12): 1859-1870. October 2022

Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation.
Brunner, A.D., Thielert, M., Vasilopoulou, C., Ammar, C., Coscia, F., Mund, A., Hoerning, O.B., Bache, N., Apalategui, A., Lubeck, M., Richter, S., Fischer, D.S., Raether, O., Park, M.A., Meier, F., Theis, F.J. and Mann, M.
Molecular Systems Biology 18 (3): e10798. 1 March 2022

Pathogen-sugar interactions revealed by universal saturation transfer analysis.
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Science 377 (6604): eabm3125. 22 July 2022

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brieño-Enríquez, M.A., Bronner, G.N., Coen, C., Delaney, M.A., Dengler-Crish, C.M., Edrey, Y.H., Faulkes, C.G., Frankel, D., Friedlander, G., Gibney, P.A., Gorbunova, V., Hine, C., Holmes, M.M., Jarvis, J.U.M., Kawamura, Y., Kutsukake, N., Kenyon, C., Khaled, W.T., Kikusui, T., Kissil, J., Lagestee, S., Larson, J., Lauer, A., Lavrenchenko, L.A., Lee, A., Levitt, J.B., Lewin, G.R., Lewis Hardell, K.N., Lin, T.D., Mason, M.J., McCloskey, D., McMahon, M., Miura, K., Mogi, K., Narayan, V., O'Connor, T.P., Okanoya, K., O'Riain, M.J., Park, T.J., Place, N.J., Podshivalova, K., Pamenter, M.E., Pyott, S.J., Reznick, J., Ruby, J.G., Salmon, A.B., Santos-Sacchi, J., Sarko, D.K., Seluanov, A., Shepard, A., Smith, M., Storey, K.B., Tian, X., Vice, E.N., Viltard, M., Watarai, Ak., Wywial, E., Yamakawa, M., Zemlemerova, E.D., Zions, M. and Smith, E.S.J.
Biological Reviews 97 (1): 115-140. February 2022

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.
Bujanic, L., Shevchuk, O., von Kügelgen, N., Kalinina, A., Ludwik, K., Koppstein, D., Zerna, N., Sickmann, A. and Chekulaeva, M.
RNA 28 (5): 766-779. May 2022

Generation of redirected engineered human chimeric antigen receptor (CAR) T cells.
Bunse, M. and Höpken, U.E.
Methods in Molecular Biology 2521 (3): 67-83. 23 June 2022

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA interdisciplinary expert consensus.
Buske, C., Dreyling, M., Alvarez-Larrán, A., Apperley, J., Arcaini, L., Besson, C., Bullinger, L., Corradini, P., Della Porta, M.G., Dimopoulos, M., D’Sa, S., Eich, H.T., Foà, R., Ghia, P., Gomes da Silva, M., Gribben, J., Hajek, R., Harrison, C., Heuser, M., Kiesewetter, B., Kiladjian, J.J., Kröger, N., Moreau, P., Passweg, J.R., Peyvandi, F., Rea, D., Ribera, J.M., Robak, T., San-Miguel, J.F., Santini, V., Sanz, G., Sonneveld, P., von Lilienfeld-Toal, M., Wendtner, C., Pentheroudakis, G. and Passamonti, F.
ESMO Open 7 (2): 100403. April 2022

Obesity, colorectal cancer and MACC1 expression: a possible novel molecular association.
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T. and Stein, U.
International Journal of Oncology 60 (2): 17. February 2022

Immune competence and spleen size scale with colony status in the naked mole-rat.
Bégay, V., Cirovic, B., Barker, A.J., Klopffleisch, R., Hart, D.W., Bennett, N.C. and Lewin, G.R.
Open Biology 12 (4): 210292. 6 April 2022

WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly.
Bögershausen, N., Krawczyk, H.E., Jamra, R.A., Lin, S.J., Yigit, G., Hüning, I., Polo, A.M., Vona, B., Huang, K., Schmidt, J., Altmüller, J., Luppe, J., Platzer, K., Dörgeloh, B.B., Busche, A., Biskup, S., Mendes, M.I., Smith, D.E.C., Salomons, G.S., Zibat, A., Bültmann, E., Nürnberg, P., Spielmann, M., Lemke, J.R., Li, Y., Zenker, M., Varshney, G.K., Hillen, H.S., Kratz, C.P. and Wollnik, B.
Human Mutation 43 (10): 1454-1471. October 2022

Organoids as tools for fundamental discovery and translation - a Keystone Symposia report.
Cable, J., Lutolf, M.P., Fu, J., Park, S.E., Apostolou, A., Chen, S., Song, C.J., Spence, J.R., Liberali, P., Lancaster, M., Meier, A.B., Pek, N.M.Q., Wells, J.M., Capeling, M.M., Uzquiano, A., Musah, S., Huch, M., Gouti, M., Hombrink, P., Quadrato, G. and Urenda, J.P.
Annals of the New York Academy of Sciences 1518 (1): 196-208. December 2022

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O., Halpert, G., Schimke, L.F., Ostrinski, Y., Vojdani, A., Baiocchi, G.C., Freire, P.P., Filgueiras, I.S., Zyskind, I., Lattin, M.T., Tran, F., Schreiber, S., Marques, A.H.C., Plaça, D.R., Fonseca, D.L.M., Humrich, J.Y., Müller, A., Giil, L.M., Graßhoff, H., Schumann, A., Hackel, A., Junker, J., Meyer, C., Ochs, H.D., Lavi, Y.B., Scheibenbogen, C., Dechend, R., Jurisica, I., Schulze-Forster, K., Silverberg, J.I., Amital, H., Zimmerman, J., Heidecke, H., Rosenberg, A.Z., Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13 (1): 1220. 9 March 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R., Aronsen, J.M., Bergan-Dahl, A., Moutty, M.C., Lunde, M., Lunde, P.K., Jarstadmarken, H., Wanichawan, P., Pereira, L., Kolstad, T.R.S., Dalhus, B., Subramanian, H., Hille, S., Christensen, G., Müller, O.J., Nikolaev, V., Bers, D.M., Sjaastad, I., Shen, X., Louch, W.E., Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: evaluation of 794 attacks from a nationwide registry in Argentina.
Carnero Contentti, E., Lopez, P.A., Pettinicchi, J.P., Criniti, J., Pappolla, A., Miguez, J., Patrucco, L., Cristiano, E., Liwacki, S., Tkachuk, V., Balbuena, M.E., Vrech, C., Deri, N., Correale, J., Marrodan, M., Ysrraelit, M.C., Leguizamon, F., Luetic, G., Menichini, M.L., Tavolini, D., Mainella, C., Zanga, G., Burgos, M., Hryb, J., Barboza, A., Lazaro, L., Alonso, R., Fernández Liguori, N., Nadur, D., Chercoff, A., Alonso Serena, M., Caride, A., Paul, F. and Rojas, J.I.
Multiple Sclerosis and Related Disorders 58 : 103466. February 2022

Heterogeneity of diabetes: β-cells, phenotypes, and precision medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.
Cefalu, W.T., Andersen, D.K., Arreaza-Rubín, G., Pin, C.L., Sato, S., Verchere, C.B., Woo, M. and Rosenblum, N.D.
Diabetes 71 (1): 1–22. January 2022

Building a Healthcare Alliance for Resourceful Medicine Offensive Against Neoplasms in hematologY added value framework for hematologic malignancies: a comparative analysis of existing tools.
Cerisoli, F., Ali, F., Bereczky, T., Bolaños, N., Bullinger, L., Dhanasiri, S., Gallagher, J., Pérez, S.G., Geissler, J., Guillevic, Y., Harrison, K., Naoum, A., Portulano, C., Rodríguez Vicente, A.E., Schulze-Rath, R., Gómez, G.Y., Sanz, G. and Hernández Rivas, J.M.
Value in Health 25 (10): 1760-1767. October 2022

Association of maintenance intravenous immunoglobulin with prevention of relapse in adult myelin oligodendrocyte glycoprotein antibody-associated disease.
Chen, J.J., Huda, S., Hacohen, Y., Levy, M., Lotan, I., Wilf-Yarkoni, A., Stiebel-Kalish, H., Hellmann, M.A., Sotirchos, E.S., Henderson, A.D., Pittock, S.J., Bhatti, M.T., Eggenberger, E.R., Di Nome, M., Kim, H.J., Kim, S.H., Saiz, A., Paul, F., Dale, R.C., Ramanathan, S., Palace, J., Camera, V., Leite, M.I., Lam, B.L., Bennett, J.L., Mariotto, S., Hodge, D., Audoin, B., Maillart, E., Deschamps, R., Pique, J., Flanagan, E.P. and Marignier, R.
JAMA Neurology 79 (5): 518-525. 1 May 2022

OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis: RNFL thickening in acute optic neuritis from MOGAD vs MS.
Chen, J.J., Sotirchos, E.S., Henderson, A.D., Vasileiou, E.S., Flanagan, E.P., Bhatti, M.T., Jamali, S., Eggenberger, E.R., Dinome, M., Frohman, L.P., Arnold, A.C., Bonelli, L., Seleme, N., Mejia-Vergara, A.J., Moss, H.E., Padungkiatsagul, T., Stiebel-Kalish, H., Lotan, I., Hellmann, M.A., Hodge, D., Oertel, F.C., Paul, F., Saidha, S., Calabresi, P.A. and Pittock, S.J.
Multiple Sclerosis and Related Disorders 58 : 103525. February 2022

The intrinsic and extrinsic effects of TET proteins during gastrulation.
Cheng, S., Mittnenzweig, M., Mayshar, Y., Lifshitz, A., Dunjić, M., Rais, Y., Ben-Yair, R., Gehrs, S., Chomsky, E., Mukamel, Z., Rubinstein, H., Schlereth, K., Reines, N., Orenbuch, A.H., Tanay, A. and Stelzer, Y.
Cell 185 (17): 3169-3185. 18 August 2022

Prediction of high and low disease activity in early MS patients using multiple kernel learning identifies importance of lateral ventricle intensity.
Chien, C., Seiler, M., Eitel, F., Schmitz-Hübsch, T., Paul, F. and Ritter, K.
Multiple Sclerosis Journal Experimental Translational and Clinical 8 (3): 20552173221109770. 1 July 2022

Motor signature of autism spectrum disorder in adults without intellectual impairment.
Cho, A.B., Otte, K., Baskow, I., Ehlen, F., Maslahati, T., Mansow-Model, S., Schmitz-Hübsch, T., Behnia, B. and Roepke, S.
Scientific Reports 12 (1): 7670. 10 May 2022

A high-resolution map of human RNA translation.
Chothani, S.P., Adami, E., Widjaja, A.A., Langley, S.R., Viswanathan, S., Pua, C.J., Zhihao, N.T., Harmston, N., D'Agostino, G., Whiffin, N., Mao, W., Ouyang, J.F., Lim, W.W., Lim, S., Lee, C.Q.E., Grubman, A., Chen, J., Kovalik, J.P., Tryggvason, K., Polo, J.M., Ho, L., Cook, S.A., Rackham, O.J.L. and Schafer, S.
Molecular Cell 82 (15): 2885-2899.e8. 4 August 2022

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9.
Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F. and Damm, F.
Leukemia 36 (4): 1102-1110. April 2022

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

A novel complex genomic rearrangement affecting the KCNJ2 regulatory region causes a variant of Cooks syndrome.
Cinque, L., Micale, L., Manara, E., Esposito, A., Palumbo, O., Chiariello, A.M., Bianco, S., Guerri, G., Bertelli, M., Giuffrida, M.G., Bernardini, L., Notarangelo, A., Nicodemi, M. and Castori, M.
Human Genetics 141 (2): 217-227. February 2022

Simultaneous genetic ablation of PD-1, LAG-3, and TIM-3 in CD8 T cells delays tumor growth and improves survival outcome.
Ciraolo, E., Althoff, S., Ruß, J., Rosnev, S., Butze, M., Pühl, M., Frentsch, M., Bullinger, L. and Na, I.K.
International Journal of Molecular Sciences 23 (6): 3207. 16 March 2022

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.
Cockman, M.E., Sugimoto, Y., Pegg, H.B., Masson, N., Salah, E., Tumber, A., Flynn, H.R., Kirkpatrick, J.M., Schofield, C.J. and Ratcliffe, P.J.
Proceedings of the National Academy of Sciences of the United States of America 119 (32): e2201483119. 9 August 2022

Towards the biogeography of prokaryotic genes.
Coelho, L.P., Alves, R., Del Río, Á.R., Myers, P.N., Cantalapiedra, C.P., Giner-Lamia, J., Schmidt, T.S., Mende, D.R., Orakov, A., Letunic, I., Hildebrand, F., Van Rossum, T., Forslund, S.K., Khedkar, S., Maistrenko, O.M., Pan, S., Jia, L., Ferretti, P., Sunagawa, S., Zhao, X.M., Nielsen, H.B., Huerta-Cepas, J. and Bork, P.
Nature 601 (7892): 252-256. 13 January 2022

Efficient computational implementation of polymer physics models to explore chromatin structure.
Conte, M., Esposito, A., Fiorillo, L., Campanile, R., Annunziatella, C., Corrado, A., Chiariello, M.G., Bianco, S. and Chiariello, A.M.
International Journal of Parallel, Emergent and Distributed Systems 37 (1): 91-102. January 2022

A polymer physics model to dissect genome organization in healthy and pathological phenotypes.
Conte, M., Fiorillo, L., Bianco, S., Chiariello, A.M., Esposito, A., Musella, F., Flora, F., Abraham, A. and Nicodemi, M.
Methods in Molecular Biology 2301 : 307-316. 2022

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
Conte, M., Irani, E., Chiariello, A.M., Abraham, A., Bianco, S., Esposito, A. and Nicodemi, M.
Nature Communications 13 (1): 4070. 13 July 2022

Differences in age-related retinal and cortical atrophy rates in multiple sclerosis.
Cordano, C., Nourbakhsh, B., Yiu, H.H., Papinutto, N., Caverzasi, E., Abdelhak, A., Oertel, F.C., Beaudry-Richard, A., Santaniello, A., Sacco, S., Bennett, D.J., Gomez, A., Sigurdson, C.J., Hauser, S.L., Magliozzi, R., Cree, B.A.C., Henry, R.G. and Green, A.J.
Neurology 99 (15): e1685-e1693. 11 October 2022

Hypothalamic galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop.
Corradi, L., Bruzzone, M., Maschio, M.D., Sawamiphak, S. and Filosa, A.
Current Biology 32 (7): 1497-1510. 11 April 2022

Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae.
Corradi, L., Zaupa, M., Sawamiphak, S. and Filosa, A.
STAR Protocols 3 (4): 101731. 16 December 2022

Retinoids are not linked to risk of multiple sclerosis: a Danish nationwide cohort study.
Cortes-Figueiredo, F., Nielsen, N.M., Stenager, E., Paul, F., Hallas, J. and Kristensen, K.B.
European Journal of Neurology 2 (1): 247-256. 18 January 2022

Combining callers improves the detection of copy number variants from whole-genome sequencing.
Coutelier, M., Holtgrewe, M., Jäger, M., Flöttman, R., Mensah, M.A., Spielmann, M., Krawitz, P., Horn, D., Beule, D. and Mundlos, S.
European Journal of Human Genetics 30 (2): 178-186. February 2022

Svep1 stabilises developmental vascular anastomosis in reduced flow conditions.
Coxam, B., Collins, R.T., Hußmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C.S.M., Stainier, D.Y.R., Schulte-Merker, S. and Gerhardt, H.
Development 149 (6): dev199858. 24 March 2022

Myogenic vasoconstriction requires canonical G(q/11) signaling of the angiotensin II type 1 receptor.
Cui, Y., Kassmann, M., Nickel, S., Zhang, C., Alenina, N., Anistan, Y.M., Schleifenbaum, J., Bader, M., Welsh, D.G., Huang, Y. and Gollasch, M.
Journal of the American Heart Association 11 (4): e022070. 15 February 2022

Associations of ultra-processed food intake with maternal weight change and cardiometabolic health and infant growth.
Cummings, J.R., Lipsky, L.M., Schwedhelm, C., Liu, A. and Nansel, T.R.
International Journal of Behavioral Nutrition and Physical Activity 19 (1): 61. 26 May 2022

Hemostatic management in an infant with neuroblastoma and severe hemophilia B with extended half-life recombinant factor IX fusion protein.
Cuntz, F., Deubzer, H.E., Schulte, J.H., Nimtz-Talaska, A., Eggert, A. and Holzhauer, S.
Journal of Pediatric Hematology Oncology 44 (1): e246-e249. 1 January 2022

Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension.
Dahale, S., Ruiz-Orera, J., Silhavy, J., Hübner, N., van Heesch, S., Pravenec, M. and Atanur, S.S.
Life Science Alliance 5 (4): e202101234. April 2022

Combination of Wnt/β-catenin targets S100A4 and DKK1 improves prognosis of human colorectal cancer.
Dahlmann, M., Monks, A., Harris, E.D., Kobelt, D., Osterland, M., Khaireddine, F., Herrmann, P., Kemmner, W., Burock, S., Walther, W., Shoemaker, R.H. and Stein, U.
Cancers 14 (1): 37. 2022

Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases.
Damerau, A., Kirchner, M., Pfeiffenberger, M., Ehlers, L., Do Nguyen, D.H., Mertins, P., Bartek, B., Maleitzke, T., Palmowski, Y., Hardt, S., Winkler, T., Buttgereit, F. and Gaber, T.
Metabolic Engineering 72 : 116-132. July 2022

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum, R., Suwalski, P., Asgharian, H., Du Zhipei, G., Lin, H., Weiner, J., Holtgrewe, M., Thibeault, C., Müller, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Blüher, A., Siemann, S., Telman, D., Suttorp, N., Witzenrath, M., Hippenstiel, S., Skurk, C., Poller, W., Sander, L.E., Beule, D., Kurth, F., Guettouche, T., Landmesser, U., Berka, J., Luong, K., Rubelt, F. and Heidecker, B.
EClinicalMedicine 48 : 101438. June 2022

Diagnostik, Therapie und die Bedeutung der Lebensqualität von Patienten mit chronischem Koronarsyndrom [Diagnostics, therapy and the importance of quality of life in patients with chronic coronary syndrome. Results oft the general practitioner care study ALTHEA].
Dechend, R.
MMW Fortschritte der Medizin 164 (Suppl 6): 11-17. 22 April 2022

Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Degenhardt, F., Ellinghaus, D., Juzenas, S., Lerga-Jaso, J., Wendorff, M., Maya-Miles, D., Uellendahl-Werth, F., ElAbd, H., Rühlemann, M.C., Arora, J., Özer, O., Lenning, O.B., Myhre, R., Vadla, M.S., Wacker, E.M., Wienbrandt, L., Ortiz, A.B., de Salazar, A., Chercoles, A.G., Palom, A., Ruiz, A., Garcia-Fernandez, A.E., Blanco-Grau, A., Mantovani, A., Zanella, A., Holten, A.R., Mayer, A., Bandera, A., Cherubini, A., Protti, A., Aghemo, A., Gerussi, A., Ramirez, A., Braun, A., Nebel, A., Barreira, A., Lleo, A., Teles, A., Kildal, A.B., Biondi, A., Caballero-Garralda, A., Ganna, A., Gori, A., Glück, A., Lind, A., Tanck, A., Hinney, A., Nolla, A.C., Fracanzani, A.L., Peschuck, A., Cavallero, A., Dyrhol-Riise, A.M., Ruello, A., Julià, A., Muscatello, A., Pesenti, A., Voza, A., Rando-Segura, A., Solier, A., Schmidt, A., Cortes, B., Mateos, B., Nafria-Jimenez, B., Schaefer, B., Jensen, B., Bellinghausen, C., Maj, C., Ferrando, C., Horra, C., Quereda, C., Skurk, C., Thibeault, C., Scollo, C., Herr, C., Spinner, C.D., Gassner, C., Lange, C., Hu, C., Paccapelo, C., Lehmann, C., Angelini, C., Cappadona, C., Azuure, C., Bianco, C., Cea, C., Sancho, C., Hoff, D.A.L., Galimberti, D., Prati, D., Haschka, D., Jiménez, D., Pestaña, D., Toapanta, D., Muñiz-Diaz, E., Azzolini, E., Sandoval, E., Binatti, E., Scarpini, E., Helbig, E.T., Casalone, E., Urrechaga, E., Paraboschi, E.M., Pontali, E., Reverter, E., Calderón, E.J., Navas, E., Solligård, E., Contro, E., Arana-Arri, E., Aziz, F., Garcia, F., Sánchez, F.G., Ceriotti, F., Martinelli-Boneschi, F., Peyvandi, F., Kurth, F., Blasi, F., Malvestiti, F., Medrano, F.J., Mesonero, F., Rodriguez-Frias, F., Hanses, F., Müller, F., Hemmrich-Stanisak, G., Bellani, G., Grasselli, G., Pezzoli, G., Costantino, G., Albano, G., Cardamone, G., Bellelli, G., Citerio, G., Foti, G., Lamorte, G., Matullo, G., Baselli, G., Kurihara, H., Neb, H., My, I., Kurth, I., Hernández, I., Pink, I., Rojas, I., Galván-Femenia, I., Holter, J.C., Afset, J.E., Heyckendorf, J., Kässens, J., Damås, J.K., Rybniker, J., Altmüller, J., Ampuero, J., Martín, J., Erdmann, J., Banales, J.M., Badia, J.R., Dopazo, J., Schneider, J., Bergan, J., Barretina, J., Walter, J., Quero, J.H., Goikoetxea, J., Delgado, J., Guerrero, J.M., Fazaal, J., Kraft, J., Schröder, J., Risnes, K., Banasik, K., Müller, K.E., Gaede, K.I., Garcia-Etxebarria, K., Tonby, K., Heggelund, L., Izquierdo-Sanchez, L., Bettini, L.Rachele, Sumoy, L., Sander, L.E., Lippert, L.J., Terranova, L., Nkambule, L., Knopp, L., Gustad, L.T., Garbarino, L., Santoro, L., Téllez, L., Roade, L., Ostadreza, M., Intxausti, M., Kogevinas, M., Riveiro-Barciela, M., Berger, M.M., Schaefer, M., Niemi, M.E.K., Gutiérrez-Stampa, M.A., Carrabba, M., Figuera Basso, M.E., Valsecchi, M.G., Hernandez-Tejero, M., Vehreschild, M.J.G.T, Manunta, M., Acosta-Herrera, M., D'Angiò, M., Baldini, M., Cazzaniga, M., Grimsrud, M.M., Cornberg, M., Nöthen, M.M., Marquié, M., Castoldi, M., Cordioli, M., Cecconi, M., D'Amato, M., Augustin, M., Tomasi, M., Boada, M., Dreher, M., Seilmaier, M.J., Joannidis, M., Wittig, M., Mazzocco, M., Ciccarelli, M., Rodríguez-Gandía, M., Bocciolone, M., Miozzo, M., Ayo, N.I., Blay, N., Chueca, N., Montano, N., Braun, N., Ludwig, N., Marx, N., Martínez, N., Cornely, O.A., Witzke, O., Palmieri, O., Faverio, P., Preatoni, P., Bonfanti, P., Omodei, P., Tentorio, P., Castro, P., Rodrigues, P.M., España, P.P., Hoffmann, P., Rosenstiel, P., Schommers, P., Suwalski, P., Pablo, R., Ferrer, R., Bals, R., Gualtierotti, R., Gallego-Durán, R., Nieto, R., Carpani, R., Morilla, R., Badalamenti, S., Haider, S., Ciesek, S., May, S., Bombace, S., Marsal, S., Pigazzini, S., Klein, S., Pelusi, S., Wilfling, S., Bosari, S., Volland, S., Brunak, S., Raychaudhuri, S., Schreiber, S., Heilmann-Heimbach, S., Aliberti, S., Ripke, S., Dudman, S., Wesse, T., Zheng, T., Bahmer, T., Eggermann, T., Illig, T., Brenner, T., Pumarola, T., Feldt, T., Folseraas, T., Cejudo, T.G., Landmesser, U., Protzer, U., Hehr, U., Rimoldi, V., Monzani, V., Skogen, V., Keitel, V., Kopfnagel, V., Friaza, V., Andrade, V., Moreno, V., Albrecht, W., Peter, W., Poller, W., Farre, X., Yi, X., Wang, X., Khodamoradi, Y., Karadeniz, Z., Latiano, A., Goerg, S., Bacher, P., Koehler, P., Tran, F., Zoller, H., Schulte, E.C., Heidecker, B., Ludwig, K.U., Fernández, J., Romero-Gómez, M., Albillos, A., Invernizzi, P., Buti, M., Duga, S., Bujanda, L., Hov, J.R., Lenz, T.L., Asselta, R., Cid, R., Valenti, L., Karlsen, T.H., Cáceres, M. and Franke, A.
Human Molecular Genetics 31 (23): 3945-3966. 1 December 2022

Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice.
Deimel, L.P., Liu, X., Gilbert-Jaramillo, J., Liu, S., James, W.S. and Sattentau, Q.J.
Journal of Immunological Methods 511 : 113380. December 2022

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers.
Del Moral-Sánchez, I., Russell, R.A., Schermer, E.E., Cottrell, C.A., Allen, J.D., Torrents de la Peña, A., LaBranche, C.., Kumar, S., Crispin, M., Ward, A.B., Montefiori, D.C., Sattentau, Q.J., Sliepen, K. and Sanders, R.W.
NPJ Vaccines 7 (1): 27. 28 February 2022

Prevalence of hypertension and possible risk factors of hypertension unawareness among individuals aged 30-75 years from two Panamanian provinces: results from population-based cross-sectional studies, 2010 and 2019.
Del Rio, A.I., Moreno Velásquez, I., Roa, R., Montenegro Mendoza, R., Motta, J. and Quintana, H.K.
PLoS ONE 17 (11): e0276222. 28 November 2022

B(1) inhomogeneity correction of RARE MRI at low SNR: quantitative in vivo (19)F MRI of mouse neuroinflammation with a cryogenically-cooled transceive surface radiofrequency probe.
Delgado, P.R., Kuehne, A., Aravina, M., Millward, J.M., Vazquez, A., Starke, L., Waiczies, H., Pohlmann, A., Niendorf, T. and Waiczies, S.
Magnetic Resonance in Medicine 87 (4): 1952-1970. April 2022

Functional repertoire convergence of distantly related eukaryotic plankton lineages abundant in the sunlit ocean.
Delmont, T.O., Gaia, M., Hinsinger, D.D., Frémont, P., Vanni, C., Fernandez-Guerra, A., Eren, A.M., Kourlaiev, A., d'Agata, L., Clayssen, Q., Villar, E., Labadie, K., Cruaud, C., Poulain, J., Da Silva, C., Wessner, M., Noel, B., Aury, J.M., de Vargas, C., Bowler, C., Karsenti, E., Pelletier, E., Wincker, P. and Jaillon, O.
Cell Genomics 2 (5): 100123. 11 May 2022

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M., Böger, M., Yousefian, S., Grunert, C., Zhang, L., Hotz, P.W., Gottschlich, A., Köse, H., Isaakidis, K., Vonficht, D., Grünschläger, F., Rohleder, E., Wagner, K., Dönig, J., Igl, V., Brzezicha, B., Baumgartner, F., Habringer, S., Löber, J., Chapuy, B., Weidinger, C., Kobold, S., Haas, S., Busse, A.B., Müller, S., Wirth, M., Schick, M. and Keller, U.
Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo.
Demel, U.M., Lutz, R., Sujer, S., Demerdash, Y., Sood, S., Grünschläger, F., Kuck, A., Werner, P., Blaszkiewicz, S., Uckelmann, H.J., Haas, S. and Essers, M.
Blood Advances 6 (11): 3513-3528. 10 June 2022

Traveling volunteers: a multi-vendor, multi-center study on reproducibility and comparability of 4D flow derived aortic hemodynamics in cardiovascular magnetic resonance.
Demir, A., Wiesemann, S., Erley, J., Schmitter, S., Trauzeddel, R.F., Pieske, B., Hansmann, J., Kelle, S. and Schulz-Menger, J.
Journal of Magnetic Resonance Imaging 55 (1): 211-222. January 2022

Ibrutinib- and bortezomib-extended R-CHOP induction in elderly higher-risk patients newly diagnosed with diffuse large B-cell lymphoma - first analysis of toxicity and efficacy signals.
Denker, S., Bittner, A., Frick, M., Kase, J., Hoffmann, J., Trenker, C., Keller, U., Bogner, C., Hüttmann, A., Dürig, J., Janz, M., Mathas, S., Marks, R., Krohn, U., Na, I.K., Bullinger, L. and Schmitt, C.A.
Leukemia & Lymphoma 63 (1): 84-92. January 2022

A comparison of solvent-based extraction methods to assess the central carbon metabolites in mouse bone and muscle.
Dias, D.B., Fritsche-Guenther, R., Gutmann, F., Duda, G.N., Kirwan, J. and Poh, P.S.P.
Metabolites 12 (5): 453. 18 May 2022

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
Dieckmann, S., Strohmeyer, A., Willershäuser, M., Maurer, S.F., Wurst, W., Marschall, S., Hrabě de Angelis, M., Kühn, R., Worthmann, A., Fuh, M.M., Heeren, J., Köhler, N., Pauling, J.K. and Klingenspor, M.
American Journal of Physiology Endocrinology and Metabolism 322 (2): E85-E100. February 2022

Motion-compensated fat-water imaging for 3D cardiac MRI at ultra-high fields.
Dietrich, S., Aigner, C.S., Mayer, J., Kolbitsch, C., Schulz-Menger, J., Schaeffter, T. and Schmitter, S.
Magnetic Resonance in Medicine 87 (6): 2621-2636. June 2022

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

Hmga2 protein loss alters nuclear envelope and 3D chromatin structure.
Divisato, G., Chiariello, A.M., Esposito, A., Zoppoli, P., Zambelli, F., Elia, M.A., Pesole, G., Incarnato, D., Passaro, F., Piscitelli, S., Oliviero, S., Nicodemi, M., Parisi, S. and Russo, T.
BMC Biology 20 (1): 171. 2 August 2022

Brief research report: Quantitative analysis of potential coronary microvascular disease in suspected long-COVID syndrome.
Doeblin, P., Steinbeis, F., Scannell, C.M., Goetze, C., Al-Tabatabaee, S., Erley, J., Faragli, A., Pröpper, F., Witzenrath, M., Zoller, T., Stehning, C., Gerhardt, H., Sánchez-González, J., Alskaf, E., Kühne, T., Pieske, B., Tschöpe, C., Chiribiri, A. and Kelle, S.
Frontiers in Cardiovascular Medicine 9 : 877416. 31 May 2022

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J., Bamopoulos, S.A., Köse, H., Orben, F., Zang, C., Pons, M., den Dekker, A.T., Brouwer, R.W.W., Baluapuri, A., Habringer, S., Reichert, M., Illendula, A., Krämer, O.H., Schick, M., Wolf, E., van IJcken, W.F.J., Esposito, I., Keller, U., Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119 (9): e2105691119. 1 March 2022

Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J., Baranovskii, A., Ronen, J., Uyar, B., Franke, V. and Akalin, A.
Genome Biology 23 (1): 123. 30 May 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Simultaneous imaging and flow-cytometry-based detection of multiple fluorescent senescence markers in therapy-induced senescent cancer cells.
Dovjak, E., Mairhofer, M., Wöß, C., Qi, J., Fan, D.N.Y., Schmitt, C.A. and Yu, Y.
Journal of Visualized Experiments (185): e63973. 12 July 2022

Increase in mental disorders during the COVID-19 pandemic -- the role of occupational and financial strains. An analysis of the German National Cohort (NAKO) Study.
Dragano, N., Reuter, M., Peters, A., Engels, M., Schmidt, B., Greiser, K.H., Bohn, B., Riedel-Heller, S., Karch, A., Mikolajczyk, R., Krause, G., Lang, O., Panreck, L., Rietschel, M., Brenner, H., Fischer, B., Franzke, C.W., Gastell, S., Holleczek, B., Jöckel, K.H., Kaaks, R., Keil, T., Kluttig, A., Kuß, O., Legath, N., Leitzmann, M., Lieb, W., Meinke-Franze, C., Michels, K.B., Obi, N., Pischon, T., Feinkohl, I., Rospleszcz, S., Schikowski, T., Schulze, M.B., Stang, A., Völzke, H., Willich, S.N., Wirkner, K., Zeeb, H., Ahrens, W. and Berger, K.
Deutsches Arzteblatt International 119 (11): 179-187. 18 March 2022

Deep learning for prediction of population health costs.
Drewe-Boss, P., Enders, D., Walker, J. and Ohler, U.
BMC Medical Informatics and Decision Making 22 (1): 32. 3 February 2022

Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry.
Dumont, M., Weber-Lassalle, N., Joly-Beauparlant, C., Ernst, C., Droit, A., Feng, B.J., Dubois, S., Collin-Deschesnes, A.C., Soucy, P., Vallée, M., Fournier, F., Lemaçon, A., Adank, M.A., Allen, J., Altmüller, J., Arnold, N., Ausems, M.G.E.M., Berutti, R., Bolla, M.K., Bull, S., Carvalho, S., Cornelissen, S., Dufault, M.R., Dunning, A.M., Engel, C., Gehrig, A., Geurts-Giele, W.R.R., Gieger, C., Green, J., Hackmann, K., Helmy, M., Hentschel, J., Hogervorst, F.B.L., Hollestelle, A., Hooning, M.J., Horváth, J., Ikram, M.A., Kaulfuß, S., Keeman, R., Kuang, D., Luccarini, C., Maier, W., Martens, J.W.M., Niederacher, D., Nürnberg, P., Ott, C.E., Peters, A., Pharoah, P.D.P., Ramirez, A., Ramser, J., Riedel-Heller, S., Schmidt, G., Shah, M., Scherer, M., Stäbler, A., Strom, T.M., Sutter, C., Thiele, H., van Asperen, C.J., van der Kolk, L., van der Luijt, R.B., Volk, A.E., Wagner, M., Waisfisz, Q., Wang, Q., Wang-Gohrke, S., Weber, B.H.F., Devilee, P., Tavtigian, S., Bader, G.D., Meindl, A., Goldgar, D.E., Andrulis, I.L., Schmutzler, R.K., Easton, D.F., Schmidt, M.K., Hahnen, E. and Simard, J.
Cancers 14 (14): 3363. 11 July 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L.. and Löhning, M.
Nature Communications 13 (1): 3059. 1 June 2022

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications.
Döhner, H., Weber, D., Krzykalla, J., Fiedler, W., Wulf, G.G., Salih, H.R., Lübbert, M., Kühn, M., Schroeder, T., Salwender, H., Götze, K.S., Westermann, J., Fransecky, L., Mayer, K., Hertenstein, B., Ringhoffer, M., Tischler, H.J., Machherndl-Spandl, S., Schrade, A., Paschka, P., Gaidzik, V.I., Theis, F., Thol, F.R., Heuser, M., Schlenk, R.F., Bullinger, L., Saadati, M., Benner, A., Larson, R.A., Stone, R.M., Döhner, K. and Ganser, A.
Blood Advances 6 (18): 5345-5355. 27 September 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T(H)2-biased immunization.
Ebenig, A., Muraleedharan, S., Kazmierski, J., Todt, D., Auste, A., Anzaghe, M., Gömer, A., Postmus, D., Gogesch, P., Niles, M., Plesker, R., Miskey, C., Gellhorn Serra, M., Breithaupt, A., Hörner, C., Kruip, C., Ehmann, R., Ivics, Z., Waibler, Z., Pfaender, S., Wyler, E., Landthaler, M., Kupke, A., Nouailles, G., Goffinet, C., Brown, R.J.P and Mühlebach, M.D.
Cell Reports 40 (7): 111214. 16 August 2022

Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132 (23): e160089. 1 December 2022

TCR and CAR engineering of primary human T cells.
Edes, I., Clauss, J., Stahn, R., Sada Japp, A. and Lorenz, F.K.M.
Methods in Molecular Biology 2521 (3): 85-93. 23 June 2022

Gender differences in perceptions and attitudes of medical students towards neurosurgery: a german nationwide survey.
Efe, I.E., Aliyeva, I., Beyaztas, D., Swiatek, V.M., Esene, I.N. and Abdulrauf, S.I.
World Neurosurgery 163 : 96-103. July 2022

The anti-glucocorticoid receptor antibody clone 5E4: raising awareness of unspecific antibody binding.
Ehlers, L., Kirchner, M., Mertins, P., Strehl, C., Buttgereit, F. and Gaber, T.
International Journal of Molecular Sciences 23 (9): 5049. 2 May 2022

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.
Eichinger, A., Poetschger, U., Glogova, E., Bader, P., Basu, O., Beier, R., Burkhardt, B., Classen, C.F., Claviez, A., Corbacioglu, S., Deubzer, H.E., Greil, J., Gruhn, B., Güngör, T., Kafa, K., Kühl, J.S., Lang, P., Lange, B.S., Meisel, R., Müller, I., Sauer, M.G., Schlegel, P.G., Schulz, A., Stachel, D., Strahm, B., Wawer, A., Peters, C. and Albert, M.H.
Leukemia 36 (11): 2567-2576. November 2022

Die Rolle der Hyper- und Hypohydrogenämie im klinischen Alltag - Warum pH? [The role of hyperhydrogenemia and hypohydrogenemia in the clinical setting - Why pH?].
Elitok, S. and Luft, F.C.
Nephrologie 17 : 339-353. September 2022

An integrated pharmacological, structural, and genetic analysis of extracellular versus intracellular ROS production in neutrophils.
Ellson, C.D., Goretti Riça, I., Kim, J.S., Huang, Y.M.M., Lim, D., Mitra, T., Hsu, A., Wei, E.X., Barrett, C.D., Otterbein, L.E., Hauser, C.J., Wahl, M., Delbrück, H., Heinemann, U., Oschkinat, H., Chang, C.E.A. and Yaffe, M.B.
Journal of Molecular Biology 434 (9): 167533. 15 May 2022

The spontaneous course of human herpesvirus 6 DNA-associated myocarditis and the effect of immunosuppressive intervention.
Elsanhoury, A., Kühl, U., Stautner, B., Klein, O., Krannich, A., Morris, D., Willner, M., Jankowska, E., Klingel, K., Van Linthout, S. and Tschöpe, C.
Viruses 14 (2): 299. February 2022

Walking parameters of older adults from a lower back inertial measurement unit, a 6-year longitudinal observational study.
Elshehabi, M., Del Din, S., Hobert, M.A., Warmerdam, E., Sünkel, U., Schmitz-Hübsch, T., Behncke, L.M., Heinzel, S., Brockmann, K., Metzger, F.G., Schlenstedt, C., Rochester, L., Hansen, C., Berg, D. and Maetzler, W.
Frontiers in Aging Neuroscience 14 : 789220. 8 September 2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Stammzelltherapien für Muskeldystrophien.
Escobar, H.
BIOspektrum 28 : 493–496. September 2022

Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging.
Espiritu, J., Berangi, M., Yiannakou, C., Silva, E., Francischello, R., Kuehne, A., Niendorf, T., Könneker, S., Willumeit-Römer, R. and Seitz, J.M.
Bioactive Materials 15 : 382-391. September 2022

Polymer physics reveals a combinatorial code linking 3D chromatin architecture to 1D chromatin states.
Esposito, A., Bianco, S., Chiariello, A.M., Abraham, A., Fiorillo, L., Conte, M., Campanile, R. and Nicodemi, M.
Cell Reports 38 (13): 110601. 29 March 2022

Evidence for recombinant GRP78, CALR, PDIA3 and GPI as mediators of genetic instability in human CD34+ cells.
Fabarius, A., Samra, V., Drews, O., Mörz, H., Bierbaum, M., Darwich, A., Weiss, C., Brendel, S., Kleiner, H., Seifarth, W., Greffrath, W., Hofmann, W.K., Schmitt, C.A. and Popp, H.D.
Cancers 14 (12): 2883. 11 June 2022

Development of a machine learning approach for local-scale ozone forecasting: application to Kennewick, WA.
Fan, K., Dhammapala, R., Harrington, K., Lamastro, R., Lamb, B. and Lee, Y.
Frontiers in Big Data 5 : 781309. 10 February 2022

Post-operative cognitive impairment: a cognitive epidemiology perspective.
Feinkohl, I.
Journal of Intelligence 10 (1): 18. 11 March 2022

A similarity scaling approach for organ-on-chip devices.
Feng, J.J. and Hedtrich, S.
Lab on a Chip 22 (19): 3663-3667. 7 October 2022

Isotropic 3D compressed sensing (CS) based sequence is comparable to 2D-LGE in left ventricular scar quantification in different disease entities.
Fenski, M., Grandy, T.H., Viezzer, D., Kertusha, S., Schmidt, M., Forman, C. and Schulz-Menger, J.
International Journal of Cardiovascular Imaging 38 (8): 1837-1850. August 2022

Assessing evolutionary and developmental transcriptome dynamics in homologous cell types.
Feregrino, C. and Tschopp, P.
Developmental Dynamics 251 (9): 1472-1489. September 2022

Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.
Fernandez Lahore, R.G., Pampaloni, N.P., Schiewer, E., Heim, M.M., Tillert, L., Vierock, J., Oppermann, J., Walther, J., Schmitz, D., Owald, D., Plested, A.J.R., Rost, B.R. and Hegemann, P.
Nature Communications 13 (1): 7844. 21 December 2022

Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.
Fernández Zapata, C., Giacomello, G., Spruth, E.J., Middeldorp, J., Gallaccio, G., Dehlinger, A., Dames, C., Leman, J.K.H., van Dijk, R.E., Meisel, A., Schlickeiser, S., Kunkel, D., Hol, E.M., Paul, F., Parr, M.K., Priller, J. and Böttcher, C.
Nature Communications 13 (1): 7210. 23 November 2022

Recent analytical approaches for the study of bioavailability and metabolism of bioactive phenolic compounds.
Fernández-Ochoa, Á., Cádiz-Gurrea, M.L., Fernández-Moreno, P., Rojas-García, A., Arráez-Román, D. and Segura-Carretero, A.
Molecules 27 (3): 777. 25 January 2022

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante, F., Giaimo, B.D., Friedrich, T., Sugino, T., Mertens, D., Kugler, S., Gahr, B.M., Just, S., Pan, L., Bartkuhn, M., Potente, M., Oswald, F. and Borggrefe, T.
Cell Death & Disease 13 (7): 600. 12 July 2022

Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial.
Ferreri, A.J.M., Cwynarski, K., Pulczynski, E., Fox, C.P., Schorb, E., Celico, C., Falautano, M., Nonis, A., La Rosée, P., Binder, M., Fabbri, A., Ilariucci, F., Krampera, M., Roth, Al., Hemmaway, C., Johnson, P.W., Linton, K.M., Pukrop, T., Gørløv, J.S., Balzarotti, M., Hess, G., Keller, U., Stilgenbauer, S., Panse, J., Tucci, A., Orsucci, L., Pisani, F., Zanni, M., Krause, S.W., Schmoll, H.J., Hertenstein, B., Rummel, M., Smith, J., Thurner, L., Cabras, G., Pennese, E., Ponzoni, M., Deckert, M., Politi, L.S., Finke, J., Ferranti, A., Cozens, K., Burger, E., Ielmini, N., Cavalli, F., Zucca, E. and Illerhaus, G.
Leukemia 36 (7): 1870-1878. July 2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S., Müllerke, S., Arnold, A., Heuberger, J., Berger, H., Lin, M., Mollenkopf, H.J., Wizenty, J., Horst, D., Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Fiskin, E., Lareau, C.A., Ludwig, L.S., Eraslan, G., Liu, F., Ring, A.M., Xavier, R.J. and Regev, A.
Nature Biotechnology 40 (3): 374-381. March 2022

Presurgical thalamus volume in postoperative delirium: a longitudinal observational cohort study in older patients.
Fislage, M., Feinkohl, I., Pischon, T., Spies, C.D., Borchers, F., Winterer, G. and Zacharias, N.
Anesthesia and Analgesia 135 (1): 136-142. July 2022

Presurgical diffusion metrics of the thalamus and thalamic nuclei in postoperative delirium: a prospective two-centre cohort study in older patients.
Fislage, M., Winzeck, S., Stamatakis, E., Correia, M.M., Preller, J., Feinkohl, I., Spies, C.D., Hendrikse, J., J.C Slooter, A., Winterer, G., Pischon, T., Menon, D.K. and Zacharias, N.
NeuroImage: Clinical 36 : 103208. 2022

Subcortical volumes as early predictors of fatigue in multiple sclerosis.
Fleischer, V., Ciolac, D., Gonzalez-Escamilla, G., Grothe, M., Strauss, S., Molina Galindo, L.S., Radetz, A., Salmen, A., Lukas, C., Klotz, L., Meuth, S.G., Bayas, A., Paul, F., Hartung, H.P., Heesen, C., Stangel, M., Wildemann, B., Bergh, F.T., Tackenberg, B., Kümpfel, T., Zettl, U.K., Knop, M., Tumani, H., Wiendl, H., Gold, R., Bittner, S., Zipp, F., Groppa, S. and Muthuraman, M.
Annals of Neurology 91 (2): 192-202. February 2022

Differentiation of cerebral neoplasms with vessel size imaging (VSI).
Foda, A., Kellner, E., Gunawardana, A., Gao, X., Janz, M., Kufner, A., Khalil, A.A., Geran, R., Mekle, R., Fiebach, J.B. and Galinovic, I.
Clinical Neuroradiology 32 (1): 239-248. March 2022

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial.
Foley, J.F., Defer, G., Ryerson, L.Z., Cohen, J.A., Arnold, D.L., Butzkueven, H., Cutter, G., Giovannoni, G., Killestein, J., Wiendl, H., Smirnakis, K., Xiao, S., Kong, G., Kuhelj, R. and Campbell, N.
Lancet Neurology 21 (7): 608-619. July 2022

Therapy switches in fingolimod-treated patients with multiple sclerosis: long-term experience from the German MS Registry.
Frahm, N., Fneish, F., Ellenberger, D., Flachenecker, P., Paul, F., Warnke, C., Kleinschnitz, C., Parciak, T., Krefting, D., Hellwig, K., Haas, J., Rommer, P.S., Stahmann, A. and Zettl, U.K.
Neurology and Therapy 11 (1): 319–336. March 2022

The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K., Kirchner, M., Mertins, P., Zuberbier, T. and Babina, M.
Allergy 77 (11): 3337-3349. November 2022

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model.
Freitag, K., Sterczyk, N., Wendlinger, S., Obermayer, B., Schulz, J., Farztdinov, V., Mülleder, M., Ralser, M., Houtman, J., Fleck, L., Braeuning, C., Sansevrino, R., Hoffmann, C., Milovanovic, D., Sigrist, S.J., Conrad, T., Beule, D., Heppner, F.L. and Jendrach, M.
Journal of Neuroinflammation 19 (1): 172. 2 July 2022

Kardiomyopathie im Neugeborenenalter: Forschungsfortschritte eröffnen neue diagnostische Möglichkeiten [Cardiomyopathy in neonatal age: advances in research open up new diagnostic possibilities].
Frenzel, M., Klaassen, S., Klingel, K., Knirsch, W., Kretschmar, O., Kühnisch, J. and Oxenius, A.
Monatsschrift Kinderheilkunde 170 : 912–916. October 2022

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit.
Fritsche-Guenther, R., Gloaguen, Y., Eisenberger, A. and Kirwan, J.A.
Scientific Reports 12 (1): 7933. 13 May 2022

Microbiome and metabolome features of the cardiometabolic disease spectrum.
Fromentin, S., Forslund, S.K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M.T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R., Coelho, L.P., Falony, G., Fellahi, S., Galan, P., Galleron, N., Helft, G., Hoyles, L., Isnard, R., Le Chatelier, E., Julienne, H., Olsson, L., Pedersen, H.K., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.E., Schmidt, T.S.B., Vieira-Silva, S., Li, P., Zimmermann-Kogadeeva, M., Lewinter, C., Søndertoft, N.B., Hansen, T.H., Gauguier, D., Gøtze, J.P., Køber, L., Kornowski, R., Vestergaard, H., Hansen, T., Zucker, J.D., Hercberg, S., Letunic, I., Bäckhed, F., Oppert, J.M., Nielsen, J., Raes, J., Bork, P., Stumvoll, M., Segal, E., Clément, K., Dumas, M.E., Ehrlich, S.D. and Pedersen, O.
Nature Medicine 28 (2): 303-314. 17 February 2022

CTGF/CCN2 has a possible detrimental role in the inflammation and the remyelination failure in the early stages of multiple sclerosis.
Fuchs, L., Mausner-Fainberg, K., Luban, A., Asseyer, S.E., Golan, M., Benhamou, M., Volovitz, I., Regev, K., Vigiser, I., Piura, Y., Kolb, H., Paul, F. and Karni, A.
Journal of Neuroimmunology 371 : 577936. 15 October 2022

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts.
Gabelich, J.A., Grützke, J., Kirscht, F., Popp, O., Matz, J.M., Dittmar, G., Rug, M. and Ingmundson, A.
PLoS Pathogens 18 (9): e1010846. 20 September 2022

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso, I., Zujo, L., Wiest, I., Kodajova, P., Timelthaler, G., Edtmayer, S., Zrimšek, M., Kollmann, S., Giordano, C., Kothmayer, M., Neubauer, H.A., Dey, S., Schlederer, M., Schmalzbauer, B.S., Limberger, T., Probst, C., Pusch, O., Högler, S., Tangermann, S., Merkel, O., Schiefer, A.I., Kornauth, C., Prutsch, N., Zimmerman, M., Abraham, B., Anagnostopoulos, J., Quintanilla-Martinez, L., Mathas, S., Wolf, P., Stoiber, D., Staber, P.B., Egger, G., Klapper, W., Woessmann, W., Look, T.A., Gunning, P., Turner, S.D., Moriggl, R., Lagger, S. and Kenner, L.
Molecular Cancer 21 (1): 172. 31 August 2022

Identification and validation of small molecule analytes in mouse plasma by liquid chromatography–tandem mass spectrometry: A case study of misidentification of a short-chain fatty acid with a ketone body.
García-Rivera, Mariel A., Fernández-Ochoa, Á., Brüning, U., Fritsche-Guenther, R. and Kirwan, J.A.
Talanta 242 : 123298. 15 May 2022

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
Garipler, G., Lu, C., Morrissey, Al., Lopez-Zepeda, L.S., Pei, Y., Vidal, S.E., Zen Petisco Fiore, A.P., Aydin, B., Stadtfeld, M., Ohler, U., Mahony, S., Sanjana, N.E. and Mazzoni, E.O.
Cell Reports 38 (11): 110524. 15 March 2022

SARS-CoV-2-specific antibody (Ab) levels and the kinetic of ab decline determine Ab persistence over 1 year.
Garner-Spitzer, E., Wagner, A., Kundi, M., Stockinger, H., Ohradanova-Repic, A., Gebetsberger, L., Schoetta, A.M., Gudipati, V., Huppa, J.B., Kunert, R., Mayrhofer, P., Kreil, T.R., Farcet, M.R., Hoeltl, E. and Wiedermann, U.
Frontiers in Medicine 9 : 822316. 15 February 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L., Pick, R., Montorfani, J., Sun, M., Brighouse, D., Liaudet, N., Kammertoens, T., Blankenstein, T., Page, N., Bernier-Latamani, J., Tran, N.L., Petrova, T.V., Merkler, D., Scheiermann, C. and Hugues, S.
Science Advances 8 (23): eabl5162. 8 June 2022

Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American Heart Association.
Garovic, V.D., Dechend, R., Easterling, T., Karumanchi, S.A., McMurtry Baird, S., Magee, L.A., Rana, S., Vermunt, J.V. and August, P.
Hypertension 79 (2): e21-e41. February 2022

Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression?
Geladaris, A., Torke, S. and Weber, M.S.
CNS drugs 36 (10): 1019-1030. October 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D., Wyler, E., Landthaler, M., Obermayer, B., von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185 (3): 493-512. 3 February 2022

The role of intraspinal sensory neurons in the control of quadrupedal locomotion.
Gerstmann, K., Jurčić, N., Blasco, E., Kunz, S., de Almeida Sassi, F., Wanaverbecq, N. and Zampieri, N.
Current Biology 32 (11): 2442-2453. 6 June 2022

Improving robustness of automatic cardiac function quantification from cine magnetic resonance imaging using synthetic image data.
Gheorghiță, B.A., Itu, L.M., Sharma, P., Suciu, C., Wetzl, J., Geppert, C., Ali, M.A.A., Lee, A.M., Piechnik, S.K., Neubauer, S., Petersen, S.E., Schulz-Menger, J. and Chițiboi, T.
Scientific Reports 12 (1): 2391. 14 February 2022

Isotopic tracing of glucose metabolites in human monocytes to assess changes in inflammatory conditions.
Giacomello, G., Böttcher, C. and Parr, M.K.
STAR Protocols 3 (4): 101715. 16 December 2022

Structure-function correlates of vision loss in neuromyelitis optica spectrum disorders.
Gigengack, N.K., Oertel, F.C., Motamedi, S., Bereuter, C., Duchow, A., Rust, R., Bellmann‑Strobl, J., Ruprecht, K., Schmitz-Hübsch, T., Paul, F., Brandt, A.U. and Zimmermann, H.G.
Scientific Reports 12 (1): 17545. 20 October 2022

Aging-regulated TUG1 is dispensable for endothelial cell function.
Gimbel, A.T., Koziarek, S., Theodorou, K., Schulz, J.F., Stanicek, L., Kremer, V., Ali, T., Günther, S., Kumar, S., Jo, H., Hübner, N., Maegdefessel, L., Dimmeler, S., van Heesch, S. and Boon, R.A.
PLoS ONE 17 (9): e0265160. 29 September 2022

Rapid inflammasome activation is attenuated in post-myocardial infarction monocytes.
Giral, H., Franke, V., Moobed, M., Müller, M.F., Lübking, L., James, D.M., Hartung, J., Kuschnerus, K., Meteva, D., Seppelt, C., Jakob, P., Klingenberg, R., Kränkel, N., Leistner, D., Zeller, T., Blankenberg, S., Zimmermann, F., Haghikia, A., Lüscher, T.F., Akalin, A., Landmesser, U. and Kratzer, A.
Frontiers in Immunology 13 : 857455. 26 April 2022

Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus.
Gjaltema, R.A.F., Schwämmle, T., Kautz, P., Robson, M., Schöpflin, R., Ravid Lustig, L., Brandenburg, L., Dunkel, I., Vechiatto, C., Ntini, E., Mutzel, V., Schmiedel, V., Marsico, A., Mundlos, S. and Schulz, E.G.
Molecular Cell 82 (1): 190-208.e17. 6 January 2022

Deep learning-assisted peak curation for large-scale LC-MS metabolomics.
Gloaguen, Y., Kirwan, J.A. and Beule, D.
Analytical Chemistry 94 (12): 4930-4937. 29 March 2022

An unusual aspartic acid cluster in the reovirus attachment fiber s1 mediates stability at low pH and preserves trimeric organization.
Glorani, G., Ruwolt, M., Holton, N., Loll, B. and Neu, U.
Journal of Virology 96 (8): e0033122. April 2022

Every islet matters: improving the impact of human islet research.
Gloyn, Anna L, Ibberson, Mark, Marchetti, Piero, Powers, Alvin C, Rorsman, Patrik, Sander, M. and Solimena, Michele
Nature Metabolism 4 (8): 970-977. August 2022

Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes.
Gmach, P., Bathe-Peters, M., Telugu, N., Miller, D.C. and Annibale, P.
International Journal of Molecular Sciences 23 (18): 10405. 8 September 2022

Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O., Zincke, F., Eckert, A., Kobelt, D., Preissner, S., Liebeskind, J.M., Gunkel, N., Putzker, K., Lewis, J., Preissner, S., Kortüm, B., Walther, W., Mura, K., Bourne, P.E., Stein, U. and Preissner, R.
Clinical and Translational Medicine 12 (2): e726. 20 February 2022

Expression of circ_Satb1 is decreased in mesial temporal lobe epilepsy and regulates dendritic spine morphology.
Gomes-Duarte, A., Venø, M.T., de Wit, M., Senthilkumar, K., Broekhoven, M.H., van den Herik, J., Heeres, F.R., van Rossum, D., Rybiczka-Tesulov, M., Legnini, I., van Rijen, P.C., van Eijsden, P., Gosselaar, P.H., Rajewsky, N., Kjems, J., Vangoor, V.R. and Pasterkamp, R.J.
Frontiers in Molecular Neuroscience 15 : 832133. 3 March 2022

Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
Grabowski, K., Herlan, L., Witten, A., Qadri, F., Eisenreich, A., Lindner, D., Schädlich, M., Schulz, A., Subrova, J., Mhatre, K.N., Primessnig, U., Plehm, R., van Linthout, S., Escher, F., Bader, M., Stoll, M., Westermann, D., Heinzel, F.R. and Kreutz, R.
Hypertension Research 45 : 292-307. January 2022

Preclinical testing of dendritic core-multishell nanoparticles in inflammatory skin equivalents.
Graff, P., Hönzke, S., Joshi, A.A., Yealland, G., Fleige, E., Unbehauen, M., Schäfer-Korting, M., Hocke, A., Haag, R. and Hedtrich, S.
Molecular Pharmaceutics 19 (6): 1795-1802. 6 June 2022

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
Grasedieck, S., Cabantog, A., MacPhee, L., Im, J., Ruess, C., Demir, B., Sperb, N., Rücker, F.G., Döhner, K., Herold, T., Pollack, J.R., Bullinger, L., Rouhi, A. and Kuchenbauer, F.
Haematologica 107 (8): 1758-1772. August 2022

Age of red cells for transfusion and outcomes in patients with ARDS.
Graw, J.A., Bünger, V., Materne, L.A., Krannich, A., Balzer, F., Francis, R.C.E., Pruß, A., Spies, C.D., Kuebler, W.M., Weber-Carstens, S., Menk, M. and Hunsicker, O.
Journal of Clinical Medicine 11 (1): 245. 4 January 2022

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.
Greco, T.M., Secker, C., Silva Ramos, E., Federspiel, J.D., Liu, J.P., Perez, A.M., Al-Ramahi, I., Cantle, J.P., Carroll, J.B., Botas, J., Zeitlin, S.O., Wanker, E.E. and Cristea, I.M.
Cell Systems 13 (4): 304-320.e5. 22 April 2022

Was ist gesichert in der Therapie der chronischen Nierenerkrankung? [What is confirmed in the treatment of chronic kidney disease?].
Greite, R. and Schmidt-Ott, K.
Innere Medizin 63 (12): 237-1243. December 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J., Kosel, F., Goveas, N., Kranz, A., Alexopoulou, D., Rajewsky, K., Sigal, M., Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

Influence of nanogel amphiphilicity on dermal delivery: balancing surface hydrophobicity and network rigidity.
Gruber, Al., Joshi, A.A., Graff, P., Cuéllar-Camacho, J.L., Hedtrich, S. and Klinger, D.
Biomacromolecules 23 (1): 112-127. 10 January 2022

Isolation of neoantigen-specific human T cell receptors from different human and murine repertoires.
Grunert, C., Willimsky, G., Peuker, C.A., Rhein, S., Hansmann, L., Blankenstein, T., Blanc, E., Beule, D., Keller, U., Pezzutto, A. and Busse, A.
Cancers 14 (7): 1842. 6 April 2022

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients.
Grunow, J.J., Reiher, K., Carbon, N.M., Engelhardt, L.J., Mai, K., Koch, S., Schefold, J.C., Z'Graggen, W., Schaller, S.J., Fielitz, J., Spranger, J., Weber-Carstens, S. and Wollersheim, T.
Critical Care 26 (1): 237. 3 August 2022

Statins aggravate the risk of insulin resistance in human muscle.
Grunwald, S.A., Haafke, S., Grieben, U., Kassner, U., Steinhagen-Thiessen, E. and Spuler, S.
International Journal of Molecular Sciences 23 (4): 2398. 21 February 2022

Fast acquisition of left and right ventricular function parameters applying cardiovascular magnetic resonance in clinical routine - validation of a 2-shot compressed sensing cine sequence.
Gröschel, J., Ammann, C., Zange, L., Viezzer, D., Forman, C., Schmidt, M., Blaszczyk, E. and Schulz-Menger, J.
Scandinavian Cardiovascular Journal 56 (1): 266-275. 14 July 2022

Different impacts on the heart after COVID-19 infection and vaccination: insights from cardiovascular magnetic resonance.
Gröschel, J., Bhoyroo, Y., Blaszczyk, E., Trauzeddel, R.F., Viezzer, D., Saad, H., Fenski, M. and Schulz-Menger, J.
Frontiers in Cardiovascular Medicine 9 : 916922. 14 July 2022

Cell-type specific inhibition controls the high-frequency oscillations in the medial entorhinal cortex.
Gurgenidze, S., Bäuerle, P., Schmitz, D., Vida, I., Gloveli, T. and Dugladze, T.
International Journal of Molecular Sciences 23 (22): 14087. 15 November 2022

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome.
Gönenc, I.I., Elcioglu, N.H., Martinez Grijalva, C., Aras, S., Großmann, N., Praulich, I., Altmüller, J., Kaulfuß, S., Li, Y., Nürnberg, P., Burfeind, P., Yigit, G. and Wollnik, B.
Clinical Genetics 101 (5-6): 559-564. May 2022

MACC1-dependent antitumor effect of curcumin in colorectal cancer.
Güllü, N., Smith, J., Herrmann, P. and Stein, U.
Nutrients 14 (22): 4792. 12 November 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G., Conlon, T.M., Jeridi, A., Kim, R., Ertüz, Z., Lang, N.J., Ansari, M., Novikova, M., Jiang, D., Strunz, M., Gaianova, M., Hollauer, C., Gabriel, C., Angelidis, I., Doll, S., Pestoni, J.C., Edelmann, S.L., Kohlhepp, M.S., Guillot, A., Bassler, K., Van Eeckhoutte, H.P., Kayalar, Ö., Konyalilar, N., Kanashova, T., Rodius, S., Ballester-López, C., Genes Robles, C.M., Smirnova, N., Rehberg, M., Agarwal, C., Krikki, I., Piavaux, B., Verleden, S.E., Vanaudenaerde, B., Königshoff, M., Dittmar, G., Bracke, K.R., Schultze, J.L., Watz, H., Eickelberg, O., Stoeger, T., Burgstaller, G., Tacke, F., Heissmeyer, V., Rinkevich, Y., Bayram, H., Schiller, H.B., Conrad, M., Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

A molecularly characterized preclinical platform of subcutaneous renal cell carcinoma (RCC) patient-derived xenograft models to evaluate novel treatment strategies.
Gürgen, D., Becker, M., Dahlmann, M., Flechsig, S., Schaeffeler, E., Büttner, F.A., Schmees, C., Bohnert, R., Bedke, J., Schwab, M., Wendler, J.J., Schostak, M., Jandrig, B., Walther, W. and Hoffmann, J.
Frontiers in Oncology 12 : 889789. 21 June 2022

Lösliche Guanylatzyklase(sGC)-Stimulation mit Vericiguat: Von der pharmakologischen Idee bis zur Therapie der chronischen Herzinsuffizienz [Soluble guanylate cyclase (sGC) stimulation with vericiguat : from the pharmacological idea to the treatment of chronic heart failure].
Haase, N., Kedziora, S.M., Mueller, D.N. and Dechend, R.
Kardiologie 16 (6): 466-478. December 2022

Introduction of Lazy Luna an automatic software-driven multilevel comparison of ventricular function quantification in cardiovascular magnetic resonance imaging.
Hadler, T., Wetzl, J., Lange, S., Geppert, C., Fenski, M., Abazi, E., Gröschel, J., Ammann, C., Wenson, F., Töpper, A., Däuber, S. and Schulz-Menger, J.
Scientific Reports 12 (1): 6629. 22 April 2022

Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats.
Haduch, A., Danek, P.J., Kuban, W., Pukło, R., Alenina, N., Gołębiowska, J., Popik, P., Bader, M. and Daniel, W.A.
Neurochemistry International 152 : 105223. January 2022

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS).
Haffke, M., Freitag, H., Rudolf, G., Seifert, M., Doehner, W., Scherbakov, N., Hanitsch, L., Wittke, K., Bauer, S., Konietschke, F., Paul, F., Bellmann-Strobl, J., Kedor, C., Scheibenbogen, C. and Sotzny, F.
Journal of Translational Medicine 20 (1): 138. 22 March 2022

miR-142 favors naïve B cell residence in peripheral lymph nodes.
Hagen, M., Chakraborty, T., Olson, W.J., Heitz, M., Hermann-Kleiter, N., Kimpel, J., Jenewein, B., Pertoll, J., Labi, V., Rajewsky, K. and Derudder, E.
Frontiers in Immunology 13 : 847415. 10 November 2022

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia, A., Zimmermann, F., Schumann, P., Jasina, A., Roessler, J., Schmidt, D., Heinze, P., Kaisler, J., Nageswaran, V., Aigner, A., Ceglarek, U., Cineus, R., Hegazy, A.N., van der Vorst, E.P.C., Döring, Y., Strauch, C.M., Nemet, I., Tremaroli, V., Dwibedi, C., Kränkel, N., Leistner, D.M., Heimesaat, M.M., Bereswill, S., Rauch, G., Seeland, U., Soehnlein, O., Müller, D.N., Gold, R., Bäckhed, F., Hazen, S.L., Haghikia, A. and Landmesser, U.
European Heart Journal 43 (6): ehab644. 7 February 2022

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Hahn, T., Ernsting, J., Winter, N.R., Holstein, V., Leenings, R., Beisemann, M., Fisch, L., Sarink, K., Emden, D., Opel, N., Redlich, R., Repple, J., Grotegerd, D., Meinert, S., Hirsch, J.G., Niendorf, T., Endemann, B., Bamberg, F., Kröncke, T., Bülow, R., Völzke, H., von Stackelberg, O., Sowade, R.F., Umutlu, L., Schmidt, B., Caspers, S., Kugel, H., Kircher, T., Risse, B., Gaser, C., Cole, J.H., Dannlowski, U. and Berger, K.
Science Advances 8 (1): eabg9471. 7 January 2022

Long-term connectome analysis reveals reshaping of visual, spatial networks in a model with vascular dementia features.
Hall, G.R., Boehm-Sturm, P., Dirnagl, U., Finke, C., Foddis, M., Harms, C., Koch, S.P., Kuchling, J., Madan, C.R., Mueller, S., Sassi, C., Sotiropoulos, S.N., Trueman, R.C., Wallis, M.D., Yildirim, F. and Farr, T.D.
Stroke 53 (5): 1735-1745. May 2022

A comparative study of graph matching algorithms in computer vision.
Haller, S., Feineis, L., Hutschenreiter, L., Bernard, F., Rother, C., Kainmüller, D., Swoboda, P. and Savchynskyy, B.
Lecture Notes in Computer Science 13683 : 636-653. 2022

High-resolution transthoracic echocardiography accurately detects pulmonary arterial pressure and decreased right ventricular contractility in a mouse model of pulmonary fibrosis and secondary pulmonary hypertension.
Hansen, T.S., Bubb, K.J., Schiattarella, G.G., Ugander, M., Tan, T.C. and Figtree, G.A.
Journal of the American Heart Association 11 (23): e018353. 6 December 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883).
Hauke, J., Harter, P., Ernst, C., Burges, A., Schmidt, S., Reuss, A., Borde, J., De Gregorio, N., Dietrich, D., El-Balat, A., Kayali, M., Gevensleben, H., Hilpert, F., Altmüller, J., Heimbach, A., Meier, W., Schoemig-Markiefka, B., Thiele, H., Kimmig, R., Nürnberg, P., Kast, K., Richters, L., Sehouli, J., Schmutzler, R.K. and Hahnen, E.
Journal of Medical Genetics 59 (3): 248-252. March 2022

Widely applicable, extended flow cytometric stem cell enumeration panel for quality control of advanced cellular products.
Haussmann, K., Streitz, M., Takvorian, A., Grund, J., Skenderi, Z., Tietze-Bürger, C., Movassaghi, K., Künkele, A., Blum, A. and Bullinger, L.
Scientific Reports 12 (1): 17995. 26 October 2022

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M., Zywitza, V., Naitou, Y., Hamazaki, N., Goeritz, F., Hermes, R., Holtze, S., Lazzari, G., Galli, C., Stejskal, J., Diecke, S., Hildebrandt, T.B. and Hayashi, K.
Science Advances 8 (49): eabp9683. 9 December 2022

Pseudocholinesterase as a biomarker for untreated Wilson's disease.
Hefter, H., Arslan, M., Kruschel, T.S., Novak, M., Rosenthal, D., Meuth, S.G., Albrecht, P., Hartmann, C.J. and Samadzadeh, S.
Biomolecules 12 (12): 1791. December 2022

Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia.
Hegazy, A.N., Krönke, J., Angermair, S., Schwartz, S., Weidinger, C., Keller, U., Treskatsch, S., Siegmund, B. and Schneider, T.
BMC Infectious Diseases 22 (1): 537. 13 June 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P., Vonficht, D., Schnell, A., Uckelmann, H.J., Bollhagen, A., Mahmoud, M.A.A., Landua, S.L., van der Salm, E., Trautmann, C., Raffel, S., Grünschläger, F., Lutz, R., Ghosh, M., Renders, S., Correia, N., Donato, E., Dixon, K.O., Hirche, C., Andresen, C., Robens, Cl., Werner, P.S., Boch, T., Eisel, D., Osen, W., Pilz, F., Przybylla, A., Klein, C., Buchholz, F., Milsom, M.D., Essers, M.A.G., Eichmüller, S.B., Hofmann, W.K., Nowak, D., Hübschmann, D., Hundemer, M., Thiede, C., Bullinger, L., Müller-Tidow, C., Armstrong, S.A., Trumpp, A., Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29 (5): 760-775. 5 May 2022

In vivo stiffness of multiple sclerosis lesions is similar to that of normal-appearing white matter.
Herthum, H., Hetzer, S., Scheel, M., Shahryari, M., Braun, J., Paul, F. and Sack, I.
Acta Biomaterialia 138 : 410-421. 15 January 2022

A phase II trial to evaluate the combination of pixantrone and obinutuzumab for patients with relapsed aggressive lymphoma: Final results of the prospective, multicentre GOAL trial.
Hess, G., Hüttmann, A., Witzens-Harig, M., Dreyling, M.H., Keller, U., Marks, R., Ernst, T., Pott, C., Viardot, A., Frontzek, F., Trautmann, M., Ruckes, C., Deuster, O., Rosenwald, A., Theobald, M. and Lenz, G.
British Journal of Haematology 198 (3): 482-491. 1 April 2022

Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
Hesse, J., Schleimer, J.H., Maier, N., Schmitz, D. and Schreiber, S.
Nature Communications 13 (1): 3934. 8 July 2022

Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
Heumüller, A.W., Jones, A. N., Mourão, A., Klangwart, M., Shi, C., Wittig, I., Fischer, A., Muhly Reinholz, M., Buchmann, G.K., Dieterich, C., Potente, M., Braun, T., Grote, P., Jaé, N., Sattler, M. and Dimmeler, S.
Circulation Research 130 (1): 67-79. 7 January 2022

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E., Lisek, K., Vogel, R., Wulf-Goldenberg, A., Alcaniz, J., Montaudon, E., Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24 (1): 23. 1 April 2022

Inflammation and convergent placenta gene co-option contributed to a novel reproductive tissue.
Hilgers, L., Roth, O., Nolte, A.W., Schüller, A., Spanke, T., Flury, J.M., Utama, I.V., Altmüller, J., Wowor, D., Misof, B., Herder, F., Böhne, A. and Schwarzer, J.
Current Biology 32 (3): 715-724. 7 February 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Tracking by weakly-supervised learning and graph optimization for whole-embryo c. elegans lineages.
Hirsch, P., Malin-Mayor, C., Santella, A., Preibisch, S., Kainmueller, D. and Funke, J.
Lecture Notes in Computer Science 13434 : 25-35. 16 September 2022

Uncoupling the excitatory amino acid transporter 2 from its C-terminal interactome restores synaptic glutamate clearance at corticostriatal synapses and alleviates mutant huntingtin-induced hypokinesia.
Hirschberg, S., Dvorzhak, A., Rasooli-Nejad, S.M.A., Angelov, S., Kirchner, M., Mertins, P., Lättig-Tünnemann, G., Harms, C., Schmitz, D. and Grantyn, R.
Frontiers in Cellular Neuroscience 15 : 792652. 31 January 2022

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K., Obermayer, B., Hönzke, K., Fatykhova, D., Demir, Z., Löwa, A., Teixeira Alves, L.G., Wyler, E., Lopez-Rodriguez, E., Mieth, M., Baumgardt, M., Hoppe, J., Firsching, T.C., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Gruber, A.D., Ochs, M., Landthaler, M., Beule, D., Suttorp, N., Hippenstiel, S., Hocke, A.C. and Kessler, M.
Communications Biology 5 (1): 875. 25 August 2022

Effects of separated pair housing of female C57BL/6JRj mice on well-being.
Hohlbaum, K., Merle, R., Frahm, S., Rex, A., Palme, R., Thöne-Reineke, C. and Ullmann, K.
Scientific Reports 12 (1): 8819. 25 May 2022

MACC1-induced collective migration is promoted by proliferation rather than single cell biomechanics.
Hohmann, T., Hohmann, U., Dahlmann, M., Kobelt, D., Stein, U. and Dehghani, F.
Cancers 14 (12): 2857. 9 June 2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Small, cationic antifungal proteins from filamentous fungi inhibit Candida albicans growth in 3D skin infection models.
Holzknecht, J., Dubrac, S., Hedtrich, S., Galgóczy, L. and Marx, F.
Microbiology Spectrum 10 (3): e0029922. June 2022

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27 (43): 2101089. 27 October 2022

Protocol for fast scRNA-seq raw data processing using scKB and non-arbitrary quality control with COPILOT.
Hsu, C.W., Shahan, R., Nolan, T.M., Benfey, P.N. and Ohler, U.
STAR Protocols 3 (4): 101729. 16 December 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D. and Junker, J.P.
Nature Genetics 54 (8): 1227-1237. August 2022

Calorie restriction enhanced glycogen metabolism to compensate for lipid insufficiency.
Hu, L., Xia, X., Zong, Y., Gu, Y., Wei, L. and Yin, J.
Molecular Nutrition & Food Research 66 (20): 2200182. October 2022

Microglia/macrophage derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model.
Huang, Y., Motta, E., Nanvuma, C., Kuhrt, L.D., Yuan, Y., Xia, P., Lubas, M., Zhu, S., Schnauss, M., Qazi, N., Hu, F., Zhang, H., Lei, T., Synowitz, M., Flüh, C. and Kettenmann, H.
Cell Reports 39 (2): 110670. 12 April 2022

Rationale and design of the prevention of paclitaxel-related neurological side effects with lithium trial – Protocol of a multicenter, randomized, double-blind, placebo-controlled proof-of-concept phase-2 clinical trial.
Huehnchen, P., Bangemann, N., Lischewski, S., Märschenz, S., Paul, F., Schmitz-Hübsch, T., Blohmer, J.U., Eberhardt, C., Rauch, G., Flöel, A., Adam, S., Schwenkenbecher, P., Meinhold-Heerlein, I., Hoffmann, O., Ziemssen, T., Endres, M. and Boehmerle, W.
Frontiers in Medicine 9 : 967964. 11 August 2022

3D model-based super-resolution motion-corrected cardiac T1 mapping.
Hufnagel, S., Metzner, S., Kerkering, K.M., Aigner, C.S., Kofler, A., Schulz-Menger, J., Schaeffter, T. and Kolbitsch, C.
Physics in Medicine and Biology 67 (24): 245008. 9 December 2022

Women in the European Virus Bioinformatics Center.
Hufsky, F., Abecasis, A., Agudelo-Romero, P., Bletsa, M., Brown, K., Claus, C., Deinhardt-Emmer, S., Deng, L., Friedel, C.C., Gismondi, M.I., Kostaki, E.G., Kühnert, D., Kulkarni-Kale, U., Metzner, K.J., Meyer, I.M., Miozzi, L., Nishimura, L., Paraskevopoulou, S., Pérez-Cataluña, A., Rahlff, J., Thomson, E., Tumescheit, C., van der Hoek, L., Van Espen, L., Vandamme, A.M., Zaheri, M., Zuckerman, N. and Marz, M.
Viruses 14 (7): 1522. 12 July 2022

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L., Luebeck, J., Dehkordi, S.R., Colón, C.I., Li, R., Wong, I.T.L., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E., Moriceau, G., Zhang, X., Bailey, C., Houlahan, K.E., Yang, W., González, R.C., Swanton, C., Curtis, C., Jamal-Hanjani, M., Henssen, A.G., Law, J.A., Greenleaf, W.J., Lo, R.S., Mischel, P.S., Bafna, V. and Chang, H.Y.
Nature Genetics 54 (11): 1746–1754. November 2022

CSF GFAP levels in double seronegative neuromyelitis optica spectrum disorder: no evidence of astrocyte damage.
Hyun, J.W., Kim, Y., Kim, K.H., Kim, S.H., Olesen, M.N., Asgari, N., Siritho, S., Paul, F. and Kim, H.J.
Journal of Neuroinflammation 19 (1): 86. 12 April 2022

Physical performance and non-esterified fatty acids in men and women after transcatheter aortic valve implantation (TAVI).
Härdrich, M., Haase-Fielitz, A., Fielitz, J., Boschmann, M., Pivovarova-Ramich, O., Pfeiffer, A.F.H., Rudovich, N., Weylandt, K.H. and Butter, C.
Nutrients 14 (1): 203. 2 January 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

Evaluation of pharmacological rescue of melanocortin-4 receptor nonsense mutations by aminoglycoside.
Höpfner, F., Paisdzior, S., Reininghaus, N., Sohail, I., Scheerer, P., Annibale, P., Biebermann, H. and Kühnen, P.
Life 12 (11): 1793. 5 November 2022

Costs and health-related quality of life in patients with NMO spectrum disorders and MOG-antibody-associated disease: CHANCE(NMO) study.
Hümmert, M.W., Schöppe, L.M., Bellmann-Strobl, J., Siebert, N., Paul, F., Duchow, A., Pellkofer, H., Kümpfel, T., Havla, J., Jarius, S., Wildemann, B., Berthele, A., Bergh, F.T., Pawlitzki, M., Klotz, L., Kleiter, I., Stangel, M., Gingele, S., Weber, M.S., Faiss, J.H., Pul, R., Walter, A., Zettl, U., Senel, M., Stellmann, J.P., Häußler, V., Hellwig, K., Ayzenberg, I., Aktas, O., Ringelstein, M., Schreiber-Katz, O. and Trebst, C.
Neurology 98 (11): e1184-e1196. 15 March 2022

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
Ihlow, J., Gross, S., Busack, L., Flörcken, A., Jesse, J., Schwarz, M., Neuendorff, N.R., von Brünneck, A.C., Anagnostopoulos, I., Türkmen, S., Blau, I.W., Burmeister, T., Horst, D., Bullinger, L. and Westermann, J.
Haematologica 107 (8): 1773-1785. August 2022

Automated detection and localization of synaptic vesicles in electron microscopy images.
Imbrosci, B., Schmitz, D. and Orlando, M.
eNeuro 9 (1): ENEURO.0400-20.2021. January 2022

H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10 (10): e005535. 27 October 2022

Dynamics of bacteria scanning a porous environment.
Irani, E., Mokhtari, Z. and Zippelius, A.
Physical Review Letters 128 (14): 144501. 5 April 2022

Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A., Mattei, D., Radscheit, K., Compagnion, A.C., Pett, J.P., Herzel, H.P., Paolicelli, R.C., Piwecka, M., Meyer, U. and Beule, D.
International Journal of Molecular Sciences 23 (20): 12347. October 2022

Impact of the first COVID-19 lockdown in Germany on the rate of acute infections during intensive chemotherapy for Hodgkin lymphoma.
Jacob, A.S., Kaul, H., Fuchs, M., Gillessen, S., Kreissl, S., Pluetschow, A., Momotow, J., Schaub, V., Huettmann, A., Haenel, M., Zimmermann, A., Dierlamm, J., Meissner, J., Mathas, S., Martin, S., Engert, A., Hallek, M., Borchmann, P. and Lehmann, C.
Infection 50 (4): 925-932. August 2022

The bias from heaping on risk estimation: Effect of age at diagnosis of hypertension on risk of subsequent cardiovascular comorbidities.
Jaeschke, L., Becher, M., Moreno Velásquez, I., Ahrens, W., Bächle, C., Baurecht, H., Fricke, J., Greiser, K.H., Günther, K., Heier, M., Karch, A., Kluttig, A., Krist, L., Leitzmann, M., Michels, K., Mikolajczyk, R., Peters, A., Schipf, S., Völzke, H., Pischon, T. and Becher, H.
Annals of Epidemiology 74 : 84-96. October 2022

Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn, N., Jahn, E., Saadati, M., Bullinger, L., Larson, R.A., Ottone, T., Amadori, S., Prior, T.W., Brandwein, J.M., Appelbaum, F.R., Medeiros, B.C., Tallman, M.S., Ehninger, G., Heuser, M., Ganser, A., Pallaud, C., Gathmann, I., Krzykalla, J., Benner, A., Bloomfield, C.D., Thiede, C., Stone, R.M., Döhner, H. and Döhner, K.
Leukemia 36 (9): 2218-2227. September 2022

Non-redundant functions of group 2 innate lymphoid cells.
Jarick, K.J., Topczewska, P.M., Jakob, M.O., Yano, H., Arifuzzaman, M., Gao, X., Boulekou, S., Stokic-Trtica, V., Leclère, P.S., Preußer, A., Rompe, Z.A., Stamm, A., Tsou, A.M., Chu, C., Heinrich, F.R., Guerra, G.M., Durek, P., Ivanov, A., Beule, D., Helfrich, S., Duerr, C.U., Kühl, A.A., Stehle, C., Romagnani, C., Mashreghi, M.F., Diefenbach, A., Artis, D. and Klose, C.S.N.
Nature 611 (7937): 794-800. 24 November 2022

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients.
Jarius, S., Pache, F., Körtvelyessy, P., Jelčić, I., Stettner, M., Franciotta, D., Keller, E., Neumann, B., Ringelstein, M., Senel, M., Regeniter, A., Kalantzis, R., Willms, J.F., Berthele, A., Busch, M., Capobianco, M., Eisele, A., Reichen, I., Dersch, R., Rauer, S., Sandner, K., Ayzenberg, I., Gross, C.C., Hegen, H., Khalil, M., Kleiter, I., Lenhard, T., Haas, J., Aktas, O., Angstwurm, K., Kleinschnitz, C., Lewerenz, J., Tumani, H., Paul, F., Stangel, M., Ruprecht, K. and Wildemann, B.
Journal of Neuroinflammation 19 (1): 19. 20 January 2022

Semi-automated assembly of high-quality diploid human reference genomes.
Jarvis, E.D., Formenti, G., Rhie, A., Guarracino, A., Yang, C., Wood, J., Tracey, A., Thibaud-Nissen, F., Vollger, M.R., Porubsky, D., Cheng, H., Asri, M., Logsdon, G.A., Carnevali, P., Chaisson, M.J.P., Chin, C.S., Cody, S., Collins, J., Ebert, P., Escalona, M., Fedrigo, O., Fulton, R.S., Fulton, L.L., Garg, S., Gerton, J.L., Ghurye, J., Granat, A., Green, R.E., Harvey, W., Hasenfeld, P., Hastie, A., Haukness, M., Jaeger, E.B., Jain, M., Kirsche, M., Kolmogorov, M., Korbel, J.O., Koren, S., Korlach, J., Lee, J., Li, D., Lindsay, T., Lucas, J., Luo, F., Marschall, T., Mitchell, M.W., McDaniel, J., Nie, F., Olsen, H.E., Olson, N.D., Pesout, T., Potapova, T., Puiu, D., Regier, A., Ruan, J., Salzberg, S.L., Sanders, A.D., Schatz, M.C., Schmitt, A., Schneider, V.A., Selvaraj, S., Shafin, K., Shumate, A., Stitziel, N.O., Stober, C., Torrance, J., Wagner, J., Wang, J., Wenger, A., Xiao, C., Zimin, A.V., Zhang, G., Wang, T., Li, H., Garrison, E., Haussler, D., Hall, I., Zook, J.M., Eichler, E.E., Phillippy, A.M., Paten, B., Howe, K. and Miga, K.H.
Nature 611 (7936): 519-531. 17 November 2022

Efficacy and feasibility of proton beam therapy in relapsed high-risk neuroblastoma-experiences from the prospective KiProReg registry.
Jazmati, D., Hero, B., Thole-Kliesch, T.M., Merta, J., Deubzer, H.E., Bäumer, C., Heinzelmann, F., Schleithoff, S.S., Koerber, F., Eggert, A., Schwarz, R., Simon, T. and Timmermann, B.
Current Oncology 29 (11): 8222-8234. November 2022

Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice.
Jensen, M., Müller, C., Huebner, N., Patone, G., Saar, K., Choe, C.U., Schwedhelm, E. and Zeller, T.
Scientific Reports 12 (1): 5108. 24 March 2022

Prediction of activity-related energy expenditure under free-living conditions using accelerometer-derived physical activity.
Jeran, S., Steinbrecher, A., Haas, V., Mähler, A., Boschmann, M., Westerterp, K.R., Brühmann, B.A., Steindorf, K. and Pischon, T.
Scientific Reports 12 (1): 16578. 4 October 2022

Targeting cathepsin C in PR3-ANCA vasculitis.
Jerke, U., Eulenberg-Gustavus, C., Rousselle, A., Nicklin, P., Kreideweiss, S., Grundl, M.A., Eickholz, P., Nickles, K., Schreiber, A., Korkmaz, B. and Kettritz, R.
Journal of the American Society of Nephrology 33 (5): 936-947. May 2022

Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin, Y., Ding, Y., Richards, M., Kaakinen, M., Giese, W., Baumann, E., Szymborska, A., Rosa, A., Nordling, S., Schimmel, L., Akmeriç, E.B., Pena, A., Nwadozi, E., Jamalpour, M., Holstein, K., Sáinz-Jaspeado, M., Bernabeu, M.O., Welsh, M., Gordon, E., Franco, C.A., Vestweber, D., Eklund, L., Gerhardt, H. and Claesson-Welsh, L.
Nature Cardiovascular Research 1 (12): 1156–1173. December 2022

Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J., Großkinsky, U., Gerlach, K., Künkele, A., Höpken, U.E. and Rehm, A.
Molecular Therapy - Methods and Clinical Development 24 : 181-198. 10 March 2022

DNA methylation-based classification of sinonasal tumors.
Jurmeister, P., Glöß, S., Roller, R., Leitheiser, M., Schmid, S., Mochmann, L.H., Payá Capilla, E., Fritz, R., Dittmayer, C., Friedrich, C., Thieme, A., Keyl, P., Jarosch, A., Schallenberg, S., Bläker, H., Hoffmann, I., Vollbrecht, C., Lehmann, A., Hummel, M., Heim, D., Haji, M., Harter, P., Englert, B., Frank, S., Hench, J., Paulus, W., Hasselblatt, M., Hartmann, W., Dohmen, H., Keber, U., Jank, P., Denkert, C., Stadelmann, C., Bremmer, F., Richter, A., Wefers, A., Ribbat-Idel, J., Perner, S., Idel, C., Chiariotti, L., Della Monica, R., Marinelli, A., Schüller, U., Bockmayr, M., Liu, J., Lund, V.J., Forster, M., Lechner, M., Lorenzo-Guerra, S.L., Hermsen, M., Johann, P.D., Agaimy, A., Seegerer, P., Koch, A., Heppner, F., Pfister, S.M., Jones, D.T.W., Sill, M., von Deimling, A., Snuderl, M., Müller, K.R., Forgó, E., Howitt, B.E., Mertins, P., Klauschen, F. and Capper, D.
Nature Communications 13 (1): 7148. 28 November 2022

Cardiac surgery-related acute kidney injury - risk factors, clinical course, management suggestions.
Just, I.A., Alborzi, F., Godde, M., Ott, S., Meyer, A., Stein, J., Mazgareanu, S., van der Giet, M., Schmidt-Ott, K.M., Falk, V. and Schoenrath, F.
Journal of Cardiothoracic and Vascular Anesthesia 36 (2): 444-451. February 2022

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K., Mensch, J., Grimmig, M.E., Neuner, B., Gorzelniak, K., Türkmen, S., Demuth, I., Hartmann, A., Hartmann, C., Wittig, F., Sporbert, A., Hermann, A., Fuellen, G., Möller, S. and Walter, M.
Science Advances 8 (33): eabk2814. August 2022

Significant reduced loss of bone mineral density after four vs. six cycles of R-CHOP: an analysis of the FLYER-trial.
Kaddu-Mulindwa, D., Lesan, V., Berdel, C., Stilgenbauer, S., Bewarder, M., Thurner, L., Witzens-Harig, M., Viardot, A., Soekler, M., Keller, U., Truemper, L., Christofyllakis, K., Fleser, O., Bittenbring, J.T., Poeschel, V., Held, G. and Jagoda, P.
Leukemia & Lymphoma 63 (2): 326-334. February 2022

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B., Marenholz, I., Jeanrenaud, A.C.S.N., Meixner, L., Arnau-Soler, A., Rosillo-Salazar, O.D., Ghauri, A., Cibin, P., Blümchen, K., Schlags, R., Hansen, G., Seidenberg, J., Keil, T., Lau, S., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 150 (5): 1125-1134. November 2022

Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial.
Kalb, B., Meixner, L., Trendelenburg, V., Unterleider, N., Dobbertin-Welsch, J., Heller, S., Dölle-Bierke, S., Roll, S., Lau, S., Lee, Y.A., Fauchère, F., Braun, J., Babina, M., Altrichter, S., Birkner, T., Worm, M. and Beyer, K.
Trials 23 (1): 210. 12 March 2022

Serotonin limits generation of chromaffin cells during adrenal organ development.
Kameneva, P., Melnikova, V.I., Kastriti, M.E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A.V., Kalinina, T.S., Kudryashov, N.V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P., Yakushov, V.D., Sheftel, B.I., Zikmund, T., Kaiser, J., Fried, K., Alenina, N., Voronezhskaya, E.E. and Adameyko, I.
Nature Communications 13 (1): 2901. 25 May 2022

(RB1)-negative retinal organoids display proliferation of cone photoreceptors and loss of retinal differentiation.
Kanber, D., Woestefeld, J., Döpper, H., Bozet, M., Brenzel, A., Altmüller, J., Kilpert, F., Lohmann, D., Pommerenke, C. and Steenpass, L.
Cancers 14 (9): 2166. 26 April 2022

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
Kaneshige, A., Kaji, T., Zhang, L., Saito, H., Nakamura, A., Kurosawa, T., Ikemoto-Uezumi, M., Tsujikawa, K., Seno, S., Hori, M., Saito, Y., Matozaki, T., Maehara, K., Ohkawa, Y., Potente, M., Watanabe, S., Braun, T., Uezumi, A. and Fukada, S.I.
Cell Stem Cell 29 (2): 265-280. 3 February 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

Automated imaging-based abdominal organ segmentation and quality control in 20,000 participants of the UK Biobank and German National Cohort Studies.
Kart, T., Fischer, M., Winzeck, S., Glocker, B., Bai, W., Bülow, R., Emmel, C., Friedrich, L., Kauczor, H.U., Keil, T., Kröncke, T., Mayer, P., Niendorf, T., Peters, A., Pischon, T., Schaarschmidt, B.M., Schmidt, B., Schulze, M.B., Umutle, L., Völzke, H., Küstner, T., Bamberg, F., Schölkopf, B., Rueckert, D. and Gatidis, S.
Scientific Reports 12 (1): 18733. 4 November 2022

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal, E., Schmidt, T.S.B., Molina-Montes, E., Rodríguez-Perales, S., Wirbel, J., Maistrenko, O.M., Akanni, W.A., Alashkar Alhamwe, B., Alves, R.J., Carrato, A., Erasmus, H.P., Estudillo, L., Finkelmeier, F., Fullam, A., Glazek, A.M., Gómez-Rubio, P., Hercog, R., Jung, F., Kandels, S., Kersting, S., Langheinrich, M., Márquez, M., Molero, X., Orakov, A., Van Rossum, T., Torres-Ruiz, R., Telzerow, A., Zych, K., Benes, V., Zeller, G., Trebicka, J., Real, F.X., Malats, N. and Bork, P.
Gut 71 (7): 1359-1372. 7 June 2022

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J., Du, W., Pruene, A., Braun, T., Thommandru, B., Turk, R., Sturgeon, M.L., Kurgan, G.L., Amini, L., Stein, M., Zittel, T., Martini, S., Ostendorf, L., Wilhelm, A., Akyüz, L., Rehm, A., Hoepken, U.E., Pruß, A., Künkele, A., Jacobi, A.M., Volk, H.D., Schmueck-Henneresse, M., Stripecke, R., Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25 : 311-330. 9 June 2022

Modular deep neural networks for automatic quality control of retinal optical coherence tomography scans.
Kauer-Bonin, J., Yadav, S.K., Beckers, I., Gawlik, K., Motamedi, S., Zimmermann, H.G., Kadas, E.M., Haußer, F., Paul, F. and Brandt, A.U.
Computers in Biology and Medicine 141 : 104822. 1 February 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M., Schaupp, A.L., Sun, R., Coscia, F., Dendrou, C.A., Cortes, A., Kaur, G., Evans, H.G., Mollbrink, A., Navarro, J.F., Sonner, J.K., Mayer, C., DeLuca, G.C., Lundeberg, J., Matthews, P.M., Attfield, K.E., Friese, M.A., Mann, M. and Fugger, L.
Nature Neuroscience 25 (7): 944-955. July 2022

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L., Petkovic, M., Watkins, T.B.K., Colliver, E.C., Laskina, S., Thapa, N., Minussi, D.C., Navin, N., Swanton, C., Van Loo, P., Haase, K., Tarabichi, M. and Schwarz, R.F.
Genome Biology 23 (1): 241. 14 November 2022

Real-time measurements of intracellular cAMP gradients using FRET-based cAMP nanorulers.
Kayser, C., Lohse, M.J. and Bock, A.
Methods in Molecular Biology 2483 : 1-13. 2022

Nonproductive exposure of PBMCs to SARS‐CoV ‐2 induces cell‐intrinsic innate immune responses.
Kazmierski, J., Friedmann, K., Postmus, D., Emanuel, J., Fischer, C., Jansen, J., Richter, A., Bosquillon de Jarcy, L., Schüler, C., Sohn, M., Sauer, S., Drosten, C., Saliba, A.E., Sander, L.E., Müller, M.A., Niemeyer, D. and Goffinet, C.
Molecular Systems Biology 18 (8): e10961. 1 August 2022

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity.
Kedor, C., Freitag, H., Meyer-Arndt, L., Wittke, K., Hanitsch, L.G., Zoller, T., Steinbeis, F., Haffke, M., Rudolf, G., Heidecker, B., Bobbert, T., Spranger, J., Volk, H.D., Skurk, C., Konietschke, F., Paul, F., Behrends, U., Bellmann-Strobl, J. and Scheibenbogen, C.
Nature Communications 13 (1): 5104. 30 August 2022

Placental transcriptome profiling in subtypes of diabetic pregnancies is strongly confounded by fetal sex.
Kedziora, S.M., Obermayer, B., Sugulle, M., Herse, F., Kräker, K., Haase, N., Langmia, I.M., Müller, D.N., Staff, A.C., Beule, D. and Dechend, R.
International Journal of Molecular Sciences 23 (23): 15388. 6 December 2022

Normative data and conversion equation for spectral-domain optical coherence tomography in an international healthy control cohort.
Kenney, R., Liu, M., Hasanaj, L., Joseph, B., Al-Hassan, A.A., Balk, L., Behbehani, R., Brandt, A.U., Calabresi, P.A., Frohman, E.M., Frohman, T., Havla, J., Hemmer, B., Jiang, H., Knier, B., Korn, T., Leocani, L., Martínez-Lapiscina, E.H., Papadopoulou, A., Paul, F., Petzold, A., Pisa, M., Villoslada, P., Zimmermann, H., Ishikawa, H., Schuman, J.S., Wollstein, G., Chen, Y., Saidha, S., Thorpe, L.E., Galetta, S.L. and Balcer, L.J.
Journal of Neuro-Ophthalmology 42 (4): 442-453. December 2022

The role of optical coherence tomography criteria and machine learning in multiple sclerosis and optic neuritis diagnosis.
Kenney, R.C., Liu, M., Hasanaj, L., Joseph, B., Al-Hassan, A.A., Balk, L.J., Behbehani, R., Brandt, A., Calabresi, P.A., Frohman, E., Frohman, T.C., Havla, J., Hemmer, B., Jiang, H., Knier, B., Korn, T., Leocani, L., Martinez-Lapiscina, E.H., Papadopoulou, A., Paul, F., Petzold, A., Pisa, M., Villoslada, P., Zimmermann, H., Thorpe, L.E., Ishikawa, H., Schuman, J.S., Wollstein, G., Chen, Y., Saidha, S., Galetta, S. and Balcer, L.J.
Neurology 99 (11): e1100-e1112. 13 September 2022

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S., Smyshlyaev, G., Letunic, I., Maistrenko, O.M., Coelho, L.P., Orakov, A., Forslund, S.K., Hildebrand, F., Luetge, M., Schmidt, T.S.B., Barabas, O. and Bork, P.
Nucleic Acids Research 50 (6): 3155-3168. 8 April 2022

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta.
Kirchenwitz, M., Stahnke, S., Prettin, S., Borowiak, M., Menke, L., Sieben, C., Birchmeier, C., Rottner, K., Stradal, T.E.B. and Steffen, A.
Cells 11 (10): 1648. 16 May 2022

Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve.
Kleineidam, L., Wolfsgruber, S., Weyrauch, A.S., Zulka, L.E., Forstmeier, S., Roeske, S., van den Bussche, H., Kaduszkiewicz, H., Wiese, B., Weyerer, S., Werle, J., Fuchs, A., Pentzek, M., Brettschneider, C., König, H.H., Weeg, D., Bickel, H., Luppa, M., Rodriguez, F.S., Freiesleben, S.D., Erdogan, S., Unterfeld, C., Peters, O., Spruth, E.J., Altenstein, S., Lohse, A., Priller, J., Fliessbach, K., Kobeleva, X., Schneider, A., Bartels, C., Schott, B.H., Wiltfang, J., Maier, F., Glanz, W., Incesoy, E.I., Butryn, M., Düzel, E., Buerger, K., Janowitz, D., Ewers, M., Rauchmann, B.S., Perneczky, R., Kilimann, I., Görß, D., Teipel, S., Laske, C., Munk, M.H.J., Spottke, A., Roy, N., Brosseron, F., Heneka, M.T., Ramirez, A., Yakupov, R., Scherer, M., Maier, W., Jessen, F., Riedel-Heller, S.G. and Wagner, M.
Frontiers in Psychology 13 : 957308. 8 December 2022

Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone 1 receptor.
Klenk, C., Hommers, L. and Lohse, M.J.
Frontiers in Endocrinology 13 : 839351. 22 February 2022

Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J., Kim, S.J., Skopnik, C.M., Hinze, C., Boltengagen, A., Metzke, D., Grothgar, E., Prskalo, L., Wagner, L., Freund, P., Görlich, N., Muench, F., Schmidt-Ott, K.M., Mashreghi, M.F., Kocks, C., Eckardt, K.U., Rajewsky, N. and Enghard, P.
Kidney International 102 (6): 1359-1370. December 2022

Meconium microbiome of very preterm infants across Germany.
Klopp, J., Ferretti, P., Meyer, C.U., Hilbert, K., Haiß, A., Marißen, J., Henneke, P., Hudalla, H., Pirr, S., Viemann, D., Zemlin, M., Forslund, S.K., Härtel, C., Bork, P., Gehring, S. and Van Rossum, T.
mSphere 7 (1): e0080821. 23 February 2022

Antibiotic resistance genes in river biofilms: a metagenomic approach toward the identification of sources and candidate hosts.
Kneis, D., Berendonk, T.U., Forslund, S.K. and Hess, S.
Environmental Science and Technology 56 (21): 14913-14922. 1 November 2022

A brief introduction to current cancer gene therapy.
Kobelt, D., Pahle, J. and Walther, W.
Methods in Molecular Biology 2521 (3): 1-21. 23 June 2022

Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade.
Kofla, G., Radecke, C., Frentsch, M., Walther, W., Stintzing, S., Riess, H., Bullinger, L. and Na, I.K.
OncoImmunology 11 (1): 2068109. 25 April 2022

Association of ultra-rare coding variants with genetic generalized epilepsy: a case-control whole exome sequencing study.
Koko, M., Motelow, J.E., Stanley, K.E., Bobbili, D.R., Dhindsa, R.S. and May, P.
Epilepsia 63 (3): 723-735. March 2022

Functional indications for transposase domestications - characterization of the human piggyBac transposase derived (PGBD) activities.
Kolacsek, O., Wachtl, G., Fóthi, Á., Schamberger, A., Sándor, S., Pergel, E., Varga, N., Raskó, T., Izsvák, Z., Apáti, Á. and Orbán, T.I.
Gene 834 : 146609. 5 August 2022

Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI.
Komorowski, A., Murgaš, M., Vidal, R., Singh, A., Gryglewski, G., Kasper, S., Wiltfang, J., Lanzenberger, R. and Goya-Maldonado, R.
Human Brain Mapping 43 (17): 5266-5280. 1 December 2022

Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study.
Konigorski, S., Janke, J., Patone, G., Bergmann, M.M., Lippert, C., Hübner, N., Kaaks, R., Boeing, H. and Pischon, T.
European Journal of Human Genetics 32 (9): 1127-1135. September 2022

Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning.
Kopp, W., Akalin, A. and Ohler, U.
Nature Machine Intelligence 4 (2): 162-168. February 2022

EASIX and severe endothelial complications after CD19-directed CAR-T Cell therapy-a cohort study.
Korell, F., Penack, O., Mattie, M., Schreck, N., Benner, A., Krzykalla, J., Wang, Z., Schmitt, M., Bullinger, L., Müller-Tidow, C., Dreger, P. and Luft, T.
Frontiers in Immunology 13 : 877477. 8 April 2022

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis.
Kortüm, B., Radhakrishnan, H., Zincke, F., Sachse, C., Burock, S., Keilholz, U., Dahlmann, M., Walther, W., Dittmar, G., Kobelt, D. and Stein, U.
Oncogene 41 (39): 4446-4458. 23 September 2022

Deletion in the Y chromosome of B10.BR-Y(del) mice alters transcription from MSYq genes and has moderate effect on DNA methylation.
Kotarska, K., Doniec, A., Korostyński, M., Piechota, M., Gołas, A., Lisowski, P. and Styrna, J.
Reproductive Biology 22 (2): 100614. June 2022

15-keto-Prostaglandin E(2) exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors.
Kourpa, A., Kaiser-Graf, D., Sporbert, A., Philippe, A., Catar, R., Rothe, M., Mangelsen, E., Schulz, A., Bolbrinker, J., Kreutz, R. and Panáková, D.
Life Sciences 310 : 121114. 1 December 2022

Computational approaches to predicting treatment response to obesity using neuroimaging.
Kozarzewski, L., Maurer, L., Mähler, A., Spranger, J. and Weygandt, M.
Reviews in Endocrine & Metabolic Disorders 23 (4): 773–805. August 2022

Reduced splenic uptake on (68)Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis.
Kraus, S., Klassen, P., Kircher, M., Dierks, A., Habringer, S., Gäble, A., Kortüm, K.M., Weinhold, N., Ademaj-Kospiri, V., Werner, R.A., Schirbel, A., Buck, A.K., Herhaus, P., Wester, H.J., Rosenwald, A., Weber, W.A., Einsele, H., Keller, U., Rasche, L. and Lapa, C.
Theranostics 12 (13): 5986-5994. 8 August 2022

A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse.
Krause, F., Mohebian, K., Delpero, M., Hesse, D., Kuehn, R., Arends, D. and Brockmann, G.A.
Mammalian Genome 33 (3): 465–470. September 2022

Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society.
Kroke, A., Schmidt, A., Amini, A.M., Kalotai, N., Lehmann, A., Haardt, J., Bauer, J.M., Bischoff-Ferrari, H.A., Boeing, H., Egert, S., Ellinger, S., Kühn, T., Louis, S., Lorkowski, S., Nimptsch, K., Remer, T., Schulze, M.B., Siener, R., Stangl, G.I., Volkert, D., Zittermann, A., Buyken, A.E., Watzl, B. and Schwingshackl, L.
European Journal of Nutrition 61 (4): 2091-2101. June 2022

Overnight unilateral withdrawal of thalamic deep brain stimulation to identify reversibility of gait disturbances.
Kroneberg, D., Al-Fatly, B., Schmitz-Hübsch, T., Gandor, F., Gruber, D., Ebersbach, G., Horn, A. and Kühn, A.A.
Experimental Neurology 355 : 114135. September 2022

GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of age-related macular degeneration.
Kropp, M., Harmening, N., Bascuas, T., Johnen, S., De Clerck, E., Fernández, V., Ronchetti, M., Cadossi, R., Zanini, C., Scherman, D., Ivics, Z., Marie, C., Izsvák, Z. and Thumann, G.
Biomedicines 10 (11): 2777. November 2022

Paracrine interleukin 6 induces cerebral remodeling at early stages after unilateral common carotid artery occlusion in mice.
Kuffner, M.T.C., Koch, S.P, Kirchner, M., Mueller, S., Lips, J., An, J., Mertins, P., Dirnagl, U., Endres, M., Boehm-Sturm, P., Harms, C. and Hoffmann, C.J.
Frontiers in Cardiovascular Medicine 8 : 805095. 27 January 2022

Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by integrated multi-omic analyses.
Kunath, B.J., Hickl, O., Queirós, P., Martin-Gallausiaux, C., Lebrun, L.A., Halder, R., Laczny, C.C., Schmidt, T.S.B., Hayward, M.R., Becher, D., Heintz-Buschart, A., de Beaufort, C., Bork, P., May, P. and Wilmes, P.
Microbiome 10 (1): 243. 28 December 2022

Small cell lung cancer stem cells display mesenchymal properties and exploit immune checkpoint pathways in activated cytotoxic T lymphocytes.
Kursunel, M.A., Taskiran, E.Z., Tavukcuoglu, E., Yanik, H., Demirag, F., Karaosmanoglu, B., Ozbay, F.G., Uner, A., Esendagli, D., Kizilgoz, D., Yilmaz, U. and Esendagli, G.
Cancer Immunology Immunotherapy 71 (2): 445-459. February 2022

Statistical analysis in the German National Cohort (NAKO) - specific aspects and general recommendations.
Kuss, O., Becher, H., Wienke, A., Ittermann, T., Ostrzinski, S., Schipf, S., Schmidt, C.O., Leitzmann, M., Pischon, T., Krist, L., Roll, S., Sand, M., Pohlabeln, H., Rach, S., Jöckel, K.H., Stang, A., Mueller, U.A., Werdecker, A., Westerman, R., Greiser, K.H. and Michels, K.B.
European Journal of Epidemiology 37 (4): 429-436. April 2022

Genome engineering in rodents - status quo and perspectives.
Kühn, R.
Laboratory Animals 56 (1): 83-87. 1 February 2022

Magnetic field-induced interactions between phones containing magnets and cardiovascular implantable electronic devices: Flip it to be safe?
Lacour, P., Dang, P.L., Heinzel, F.R., Parwani, A.S., Bähr, F., Kucher, A., Hohendanner, F., Niendorf, T., Rahimi, F., Saha, N., Han, H., Rubarth, K., Sherif, M., Boldt, L.H., Pieske, B. and Blaschke, F.
Heart Rhythm 19 (3): 372-380. March 2022

Interleukin 8 in postoperative delirium - preliminary findings from two studies.
Lammers-Lietz, F., Akyuz, L., Feinkohl, I., Lachmann, C., Pischon, T., Volk, H.D., von Häfen, C., Yürek, F., Winterer, G. and Spies, C.D.
Brain Behavior & Immunity - Health 20 : 100419. March 2022

Rapid single-cell identification of Epstein-Barr virus-specific T-cell receptors for cellular therapy.
Lammoglia Cobo, M.F., Welters, C., Rosenberger, L., Leisegang, M., Dietze, K., Pircher, C., Penter, L., Gary, R., Bullinger, L., Takvorian, A., Moosmann, A., Dornmair, K., Blankenstein, T., Kammertöns, T., Gerbitz, A. and Hansmann, L.
Cytotherapy 24 (8): 818-826. August 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T., Rose, J.C., Chen, C.Y., Pichugin, Y., Xie, L., Tang, J., Hung, K.L., Yost, K.E., Shi, Q., Erb, M.L., Rajkumar, U., Wu, S., Taschner-Mandl, S., Bernkopf, M., Swanton, C., Liu, Z., Huang, W., Chang, H.Y., Bafna, V., Henssen, A.G., Werner, B. and Mischel, P.S.
Nature Genetics 54 (10): 1527-1533. October 2022

A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments.
Langenhan, J., Jaeger, C., Baum, K., Simon, M. and Lisec, J.
Metabolites 12 (5): 408. 29 April 2022

Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling.
Langer, H.T., West, D., Senden, J., Spuler, S., van Loon, L.J.C. and Baar, K.
Scientific Reports 12 (1): 7553. 9 May 2022

Sox9 is required for nail bed differentiation and digit tip regeneration.
Lao, M., Hurtado, A., de Castro, A.C., Burgos, M., Jiménez, R. and Barrionuevo, F.J.
Journal of Investigative Dermatology 142 (10): 2613-2622. October 2022

Efficient CRISPR/Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators.
Le, T.A., Chu, V.T., Lino, A.C., Schrezenmeier, E., Kressler, C., Hamo, D., Rajewsky, K., Dörner, T. and Dang, V.D.
Molecular Therapy - Nucleic Acids 30 : 621-632. 13 December 2022

Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M., Foglierini, M., Khorkova, S., Vázquez García, C., Ratswohl, C., Davydov, A.N., Turchaninova, M.A., Daubenberger, C., Chudakov, D.M., Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

Heteroplasmy of wild type mitochondrial DNA variants in mice causes metabolic heart disease with pulmonary hypertension and frailty.
Lechuga-Vieco, A.V., Latorre-Pellicer, A., Calvo, E., Torroja, C., Pellico, J., Acín-Pérez, R., García-Gil, M.L., Santos, A., Bagwan, N., Bonzon-Kulichenko, E., Magni, R., Benito, M., Justo-Méndez, R., Simon, A.K., Sánchez-Cabo, F., Vázquez, J., Ruíz-Cabello, J. and Enríquez, J.A.
Circulation 145 (12): 1084-1101. 5 April 2022

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L., Dempsey, B., Garancher, A., Bourane, S., Ruffault, P.L., Morin-Surun, M.P., Rocques, N., Goulding, M., Eychène, A., Pouponnot, C., Fortin, G. and Champagnat, J.
Nature Communications 13 (1): 3284. 7 June 2022