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| Item Type: | Article |
|---|---|
| Title: | An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium |
| Creators: |
Worm, M.  ORCID: https://orcid.org/0000-0002-3449-1245, Alexiou, A., Höfer, V. ORCID: https://orcid.org/0000-0002-8538-3439, Birkner, T. ORCID: https://orcid.org/0000-0003-2656-2821, Jeanrenaud, A.C.S.N. ORCID: https://orcid.org/0000-0002-4230-9976, Fauchère, F. ORCID: https://orcid.org/0000-0002-1955-6362, Pazur, K. ORCID: https://orcid.org/0000-0002-3959-6986, Steinert, C. ORCID: https://orcid.org/0000-0001-5661-3613, Arnau-Soler, A. ORCID: https://orcid.org/0000-0001-9768-0513, Banerjee, P. ORCID: https://orcid.org/0000-0001-8072-5594, Diefenbach, A. ORCID: https://orcid.org/0000-0002-9176-9530, Dobbertin-Welsch, J. ORCID: https://orcid.org/0000-0003-4260-5879, Dölle-Bierke, S. ORCID: https://orcid.org/0000-0002-3339-0709, Francuzik, W. ORCID: https://orcid.org/0000-0001-5361-9876, Ghauri, A. ORCID: https://orcid.org/0000-0003-4665-3624, Heller, S. ORCID: https://orcid.org/0000-0001-5720-7334, Kalb, B. ORCID: https://orcid.org/0000-0002-3104-6736, Löber, U. ORCID: https://orcid.org/0000-0001-7468-9531, Marenholz, I. ORCID: https://orcid.org/0009-0007-6933-3849, Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Scheffel, J. ORCID: https://orcid.org/0000-0002-9365-3785, Potapenko, O. ORCID: https://orcid.org/0000-0002-4397-568X, Roll, St. ORCID: https://orcid.org/0000-0003-1191-3289, Lau, S. ORCID: https://orcid.org/0000-0002-5189-4265, Lee, Y.A. ORCID: https://orcid.org/0000-0002-1817-9163, Braun, J. ORCID: https://orcid.org/0000-0002-7788-8154, Thiel, A. ORCID: https://orcid.org/0000-0002-5515-4002, Babina, M. ORCID: https://orcid.org/0000-0002-4500-7615, Altrichter, S. ORCID: https://orcid.org/0000-0001-9955-385X, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993 and Beyer, K. ORCID: https://orcid.org/0000-0003-1859-0419
|
| Abstract: | BACKGROUND: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. METHODS: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. RESULTS: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. CONCLUSION: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies. |
| Keywords: | Biomarker, Epigenetics, Food Allergy, Microbiome, Peanut Allergy |
| Source: | Clinical and Translational Allergy |
| ISSN: | 2045-7022 |
| Publisher: | Wiley |
| Volume: | 12 |
| Number: | 10 |
| Page Range: | e12197 |
| Date: | October 2022 |
| Official Publication: | https://doi.org/10.1002/clt2.12197 |
| PubMed: | View item in PubMed |
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