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| Item Type: | Article |
|---|---|
| Title: | Skin sodium accumulates in psoriasis and reflects disease severity |
| Creators: |
Maifeld, A.  ORCID: https://orcid.org/0000-0001-8756-747X, Wild, J. ORCID: https://orcid.org/0000-0002-1446-8101, Karlsen, T.V. ORCID: https://orcid.org/0000-0002-1512-2479, Rakova, N. ORCID: https://orcid.org/0000-0002-5397-6715, Wistorf, E. ORCID: https://orcid.org/0000-0002-5592-5743, Linz, P. ORCID: https://orcid.org/0000-0002-8232-1443, Jung, R. ORCID: https://orcid.org/0000-0002-2460-6512, Birukov, A. ORCID: https://orcid.org/0000-0002-8306-3351, Gimenez-Rivera, V.A. ORCID: https://orcid.org/0000-0001-5055-208X, Wilck, N. ORCID: https://orcid.org/0000-0003-3189-5364, Bartolomaeus, T. ORCID: https://orcid.org/0000-0002-5156-7184, Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080, Kleinewietfeld, M. ORCID: https://orcid.org/0000-0002-2832-3149, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Krause, A. ORCID: https://orcid.org/0000-0001-6000-2815, Kokolakis, G. ORCID: https://orcid.org/0000-0002-8042-7885, Philipp, S. ORCID: https://orcid.org/0000-0002-9421-5461, Clausen, B.E. ORCID: https://orcid.org/0000-0002-2484-7842, Brand, A. ORCID: https://orcid.org/0000-0002-3615-1826, Waisman, A. ORCID: https://orcid.org/0000-0003-4304-8234, Kurschus, F.C. ORCID: https://orcid.org/0000-0001-7550-0681, Wegner, J. ORCID: https://orcid.org/0000-0002-7710-9675, Schultheis, M. ORCID: https://orcid.org/0000-0002-2957-074X, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Boschmann, M. ORCID: https://orcid.org/0000-0002-0114-7114, Kelm, M. ORCID: https://orcid.org/0000-0003-4971-0452, Wiig, H. ORCID: https://orcid.org/0000-0002-7740-8210, Kuehne, T. ORCID: https://orcid.org/0000-0003-1631-4824, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Karbach, S. ORCID: https://orcid.org/0000-0003-4462-3747 and Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575
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| Abstract: | Sodium can accumulate in the skin, at concentrations exceeding serum levels. High sodium environment can lead to pathogenic T helper (Th)17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which interleukin (IL)-17-producing Th17 cells play a crucial role. In an observational study, we measured skin sodium content in psoriasis patients and age-matched healthy controls by (23)Na-magnetic resonance imaging (MRI). Patients with a psoriasis area and severity index (PASI)>5 showed significantly higher sodium and water content in the skin, but not in other tissues, compared to those with lower PASI or healthy controls. Skin sodium concentrations measured by (23)Na-spectroscopy or by atomic adsorption spectrometry in ashed-skin biopsies verified findings with (23)Na-MRI. In vitro Th17 cell differentiation of naïve CD4(+) cells from psoriatic patients markedly induced IL-17A expression under increased NaCl concentrations. The imiquimod-induced psoriasis mouse model replicated the human findings. Extracellular tracer (51)Cr-EDTA measurements in imiquimod- and sham-treated skin showed similar extracellular volumes, rendering excessive water of intracellular origin. Chronic genetic IL-17A-driven psoriasis mouse models underlined the role of IL-17A in dermal sodium accumulation and inflammation. Our data describe skin sodium as a pathophysiological feature of psoriasis, which could open new avenues for its treatment. |
| Keywords: | Atomic Spectrophotometry, Cell Differentiation, Cultured Cells, Inbred C57BL Mice, Interleukin-17, Lymphocyte Activation, Psoriasis, Severity of Illness Index, Skin, Sodium, Sodium Chloride, Spectrum Analysis, Th17 Cells, Animals, Mice |
| Source: | Journal of Investigative Dermatology |
| ISSN: | 0022-202X |
| Publisher: | Elsevier |
| Volume: | 142 |
| Number: | 1 |
| Page Range: | 166-178 |
| Date: | January 2022 |
| Additional Information: | Copyright © 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. |
| Official Publication: | https://doi.org/10.1016/j.jid.2021.06.013 |
| PubMed: | View item in PubMed |
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