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2024

Genetic determinants of micronucleus formation in vivo.
Adams, D.J., Barlas, B., McIntyre, R.E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J.R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N.A., Harle, V., Olvera-León, R., Robles-Espinoza, C.D., Speak, A.O., Geisler, N., Weninger, W.J., Geyer, S.H., Hewinson, J., Karp, N.A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M.S., Rowland, B.D., Lelliott, C.J., Del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A.G., Rooimans, M.A., de Lange, J., Mohun, T.J., Arends, M.J., Kentistou, K.A., Coelho, P.A., Zhao, Y., Zecchini, H., Perry, J.R.B., Jackson, S.P. and Balmus, G.
Nature 627 (8002): 130–136. 7 March 2024

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome.
Arlt, F.A., Breuer, A., Trampenau, E., Boesl, F., Kirchner, M., Mertins, P., Sánchez-Sendín, E., Nasouti, M., Mayrhofer, M., Blüthner, M., Endres, M., Prüss, H. and Franke, C.
Frontiers in Immunology 15 : 1404800. 2 August 2024

ADAM19 cleaves the PTH receptor and associates with brachydactyly type E.
Aydin, A., Klenk, C., Nemec, K., Işbilir, Ali, Martin, L.M., Zauber, H., Rrustemi, T., Toka, H.R., Schuster, H., Gong, M., Stricker, S., Bock, A., Bähring, S., Selbach, M., Lohse, M.J. and Luft, F.C.
Life Science Alliance 7 (4): e202302400. April 2024

In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia.
Bakina, O., Conrad, T., Mitic, N., Vidal, R.O., Obrusnik, T., Sai, S., Nolte, C., Semtner, M. and Kettenmann, H.
PLoS ONE 19 (7): e0302376. 11 July 2024

Activation of gp130 signaling in T cells drives T(H)17-mediated multi-organ autoimmunity.
Baumgartner, F., Bamopoulos, S.A., Faletti, L., Hsiao, H.J., Holz, M., Gonzalez-Menendez, I., Solé-Boldo, L., Horne, A., Gosavi, S., Özerdem, C., Singh, N., Liebig, S., Ramamoorthy, S., Lehmann, M., Demel, U., Kühl, A.A., Wartewig, T., Ruland, J., Wunderlich, F.T., Schick, M., Walther, W., Rose-John, S., Haas, S., Quintanilla-Martinez, L., Feske, S., Ehl, S., Glauben, R. and Keller, U.
Science Signaling 17 (824): eadc9662. 20 February 2024

Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15 (1): 2611. 23 March 2024

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y., Brame, Luca, Kirchner, M., Fritsche-Guenther, R., Kunz, S., Bhattacharya, A., Rusu, M.C., Gürgen, D., Dubois, F.P.B., Köppke, J.K.C., Proba, J., Wittstruck, N., Sidorova, O.A., Chamorro González, R., Dorado Garcia, H., Brückner, L., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Yu, Q., Spanjaard, B., Koche, R.P., Schmitt, C.A., Schulte, J.H., Eggert, A., Haase, K., Kirwan, J., Hagemann, A.I., Mertins, P., Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14 (3): 492-507. 1 March 2024

Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects.
Bonsor, M., Ammar, O., Schnoegl, S., Wanker, E.E. and Silva Ramos, E.
Proteomics 24 (12-13): e2300114. June 2024

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.
Borsa, M., Obba, S., Richter, F.C., Zhang, H., Riffelmacher, T., Carrelha, J., Alsaleh, G., Jacobsen, S.E.W. and Simon, A.K.
Autophagy 20 (1): 45-57. January 2024

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner, D., Sieverding, K., Srinidhi, J., Zellner, S., Secker, C., Yilmaz, R., Dyckow, J., Amr, S., Ponomarenko, A., Tunaboylu, E., Douahem, Y., Schlag, J.S., Rodríguez Martínez, L., Kislinger, G., Niemann, C., Nalbach, K., Ruf, W.P., Uhl, J., Hollenbeck, J., Schirmer, L., Catanese, A., Lobsiger, C.S., Danzer, K.M., Yilmazer-Hanke, D., Münch, C., Koch, P., Freischmidt, A., Fetting, M., Behrends, C., Parlato, R. and Weishaupt, J.H.
Journal of Experimental Medicine 221 (5): e20221190. 22 March 2024

Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383 (6686): 992-998. 1 March 2024

Reevaluating the relevance of F-FDG PET findings for diagnosis of neurosarcoidosis: a case series.
Chen, J., Metzger, G., Furth, C., Bohner, G. and Siffrin, V.
Neurological Research and Practice 6 (1): 12. 25 January 2024

Efficient recovery of complete gut viral genomes by combined short- and long-read sequencing.
Chen, J., Sun, C., Dong, Y., Jin, M., Lai, S., Jia, L., Zhao, X., Wang, H., Gao, N.L., Bork, P., Liu, Z., Chen, W.H. and Zhao, X.M.
Advanced Science 11 (13): 2305818. 3 April 2024

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression.
Chen, W., Wang, F., Yu, X., Qi, J., Dong, H., Cui, B., Zhang, Q., Wu, Y., An, J., Ni, N., Liu, C., Han, Y., Zhang, S., Schmitt, C.A., Deng, J., Yu, Y. and Du, J.
Oncogene 43 (18): 1328-1340. 2 May 2024

Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B.D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K.P.L., Flüh, C., Kälin, R.E. and Glass, R.
Cell Reports Medicine 5 (8): 101658. 20 August 2024

Next questions in autophagy.
Cuervo, A.M., Elazar, Z., Evans, C., Ge, L., Hansen, M., Jäättelä, M., Liang, J.R.A., Loos, B., Mizushima, N., Simon, A.K., Tooze, S., Yoshimori, T. and Nakamura, S.
Nature Cell Biology 26 (5): 661-666. May 2024

A point-of-research decision in synovial tissue engineering: Mesenchymal stromal cells, tissue derived fibroblast or CTGF-mediated mesenchymal-to-fibroblast transition.
Damerau, A., Kirchner, M., Mertins, P., Buttgereit, F. and Gaber, T.
European Journal of Cell Biology 103 (4): 151455. December 2024

Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown.
Daumke, O. and Damme, M.
Structure 32 (6): 645-647. 6 June 2024

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15 (1): 6851. 10 August 2024

Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments.
Demirci, H., Popovic, S., Dittmayer, C., Yilmaz, D.E., El-Shimy, I.A., Mülleder, M., Hinze, C., Su, M., Mertins, P., Kirchner, M., Osmanodja, B., Paliege, A., Budde, K., Amann, K., Persson, P.B., Mutig, K. and Bachmann, S.
Acta Physiologica 240 (8): e14190. August 2024

Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2.
Desiderio, S., Schwaller, F., Tartour, K., Padmanabhan, K., Lewin, G.R., Carroll, P. and Marmigere, F.
eLife 12 : RP89287. 22 February 2024

Towards standardizing nomenclature in Huntington's disease research.
DiFiglia, M., Leavitt, B.R., Macdonald, D. and Thompson, L.M.
Journal of Huntington's disease 13 (2): 119-131. 2 July 2024

Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly.
Dick, A., Mikirtumov, V., Fuchs, J., Krupp, F., Olal, D., Bendl, E., Sprink, T., Diebolder, C., Kudryashev, M., Kochs, G., Roske, Y. and Daumke, O.
Structure 32 (8): 1068-1078. 8 August 2024

Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer.
Dieper, A., Scheidegger, S., Füchslin, R.M., Veltsista, P.D., Stein, U., Weyland, M., Gerster, D., Beck, M., Bengtsson, O., Zips, D. and Ghadjar, P.
International Journal of Hyperthermia 41 (1): 2379992. 17 July 2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z., Zhang, S., Dupont, M., Ragaller, F., Sjule, E., Cabezas-Caballero, J., Deimel, L.P., Robertson, H., Russell, R.A., Dushek, O., Sezgin, E., Karaji, N. and Sattentau, Q.J.
Nature Communications 15 (1): 541. 15 January 2024

A catalog of small proteins from the global microbiome.
Duan, Y., Santos-Júnior, C.D., Schmidt, T.S., Fullam, A., de Almeida, B.L.S., Zhu, C., Kuhn, M., Zhao, X.M., Bork, P. and Coelho, L.P.
Nature Communications 15 (1): 7563. 31 August 2024

Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice.
Dörmann, N., Hammer, E., Struckmann, K., Rüdebusch, J., Bartels, K., Wenzel, K., Schulz, J., Gross, S., Schwanz, S., Martin, E., Fielitz, B., Pablo Tortola, C., Hahn, A., Benkner, A., Völker, U., Felix, S.B and Fielitz, J.
Frontiers in Cardiovascular Medicine 10 : 1323760. 8 January 2024

MACC1 regulates LGR5 to promote cancer stem cell properties in colorectal cancer.
Erdem, M., Lee, K.H., Hardt, M., Regan, J.L., Kobelt, D., Walther, W., Mokrizkij, M., Regenbrecht, C. and Stein, U.
Cancers 16 (3): 604. 31 January 2024

The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans.
Faitova, T., Coelho, M., Da Cunha-Bang, C., Ozturk, S., Kartal, E., Bork, P., Seiffert, M. and Niemann, C.U.
Haematologica 109 (10): 3237-3250. October 2024

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani, I., Petragnano, F., Wang, Z., Edwards, R., Telugu, N., Pietrantoni, I., Zabel, U., Zauber, H., Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Pohl, B., Aringhieri, S., Carli, M., Aloisi, G., Marampon, F., Charlesworth, E., Roman, A., Diecke, S., Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Rossi, M., Lohse, M.J., Annibale, P. and Maggio, R.
PLoS Biology 22 (4): e3002582. 29 April 2024

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Flügel, T., Schacherl, M., Unbehaun, A., Schroeer, B., Dabrowski, M., Bürger, J., Mielke, T., Sprink, T., Diebolder, C.A., Guillén Schlippe, Y.V. and Spahn, C.M.T.
Nature Communications 15 (1): 1756. 26 February 2024

Emergence of community behaviors in the gut microbiota upon drug treatment.
Garcia-Santamarina, S., Kuhn, M., Devendran, S., Maier, L., Driessen, M., Mateus, A., Mastrorilli, E., Brochado, A.R., Savitski, M.M., Patil, K.R., Zimmermann, M., Bork, P. and Typas, A.
Cell 24 September 2024 (In Press)

BTK inhibition limits microglia‑perpetuated CNS inflammation and promotes myelin repair.
Geladaris, A., Torke, S., Saberi, D., Alankus, Y.B., Streit, F., Zechel, S., Stadelmann-Nessler, C., Fischer, A., Boschert, U., Häusler, D. and Weber, M.S.
Acta Neuropathologica 147 (1): 75. 24 April 2024

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil.
Giurgiu, M., Wittstruck, N., Rodriguez-Fos, E., Chamorro González, R., Brückner, L., Krienelke-Szymansky, A., Helmsauer, K., Hartebrodt, A., Euskirchen, P., Koche, R.P., Haase, K., Reinert, K. and Henssen, A.G.
Genome Research 7 August 2024 (In Press)

Decoil: reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data.
Giurgiu, M., Wittstruck, N., Rodriguez-Fos, E., Chamorro González, R., Brückner, L., Krienelke-Szymansky, A., Helmsauer, K., Hartebrodt, A., Euskirchen, P., Koche, R.P., Haase, K., Reinert, K. and Henssen, A.G.
Lecture Notes in Computer Science 14758 : 406-411. 17 May 2024

CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment.
Greensmith, R., Lape, I.T., Riella, C.V., Schubert, A.J., Metzger, J.J., Dighe, A.S., Tan, X., Hemmer, B., Rau, J., Wendlinger, S., Diederich, N., Schütz, A., Riella, L.V. and Kaminski, M.M.
EMBO Molecular Medicine 13 September 2024 (In Press)

Mutations in CLCN6 as a novel genetic cause of neuronal ceroid lipofuscinosis in patients and a murine model.
He, H., Cao, X., He, F., Zhang, W., Wang, X., Peng, P., Xie, C., Yin, F., Li, D., Li, J., Wang, M., Klüssendorf, M., Jentsch, T.J., Stauber, T. and Peng, J.
Annals of Neurology 96 (3): 608-624. September 2024

Mesenchymal cell migration on one-dimensional micropatterns.
Heyn, J.C.J., Rädler, J.O. and Falcke, M.
Frontiers in Cell and Developmental Biology 12 : 1352279. 16 April 2024

Nourishing the mind: fasting for brain health.
Hofer, S.J. and Madeo, F.
Cell Metabolism 36 (8): 1635-1637. 6 August 2024

Structure of tetrameric forms of the serotonin-gated 5-HT3(A) receptor ion channel.
Introini, B., Cui, W., Chu, X., Zhang, Y., Alves, A.C., Eckhardt-Strelau, L., Golusik, S., Tol, M., Vogel, H., Yuan, S. and Kudryashev, M.
EMBO Journal 4 September 2024

Non-viral targeted insertion of large payloads into T cells.
Izsvak, Z.
Nature Biomedical Engineering 16 September 2024 (In Press)

Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R., Gold, C., Joppich, M., Loew, Q., Akhalkatsi, A., Mueller, T.T., Offensperger, F., Droste Zu Senden, A., Popp, O., di Fina, L., Knottenberg, V., Martinez-Navarro, A., Eivers, L., Anjum, A., Escaig, R., Bruns, N., Briem, E., Dewender, R., Muraly, A., Akgöl, S., Ferraro, B., Hoeflinger, J.K.L., Polewka, V., Khaled, N.B., Allgeier, J., Tiedt, S., Dichgans, M., Engelmann, B., Enard, W., Mertins, P., Hubner, N., Weckbach, L., Zimmer, R., Massberg, S., Stark, K., Nicolai, L. and Pekayvaz, K.
Science Advances 10 (12): eadl1710. 22 March 2024

SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Kalnytska, O., Qvist, P., Kunz, S., Conrad, T., Willnow, T.E. and Schmidt, V.
iScience 27 (1): 108725. 19 January 2024

Rudolf Virchow and the discovery of the Müller cell.
Kettenmann, H.
Graefes Archive for Clinical and Experimental Ophthalmology 5 September 2024 (In Press)

Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network.
Klinger, B., Rausch, I., Siebert, A., Kutz, H., Kruse, V., Kirchner, M., Mertins, P., Kieser, A., Blüthgen, N. and Kube, D.
PLoS Computational Biology 20 (10): e1012488. 1 October 2024 (In Press)

LRRC8/VRAC volume-regulated anion channels are crucial for hearing.
Knecht, D.A., Zeziulia, M., Bhavsar, M., Puchkov, D., Maier, H. and Jentsch, T.J.
Journal of Biological Chemistry 300 (7): 107436. July 2024

Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts.
Kolesnichenko, M. and Scheidereit, C.
Signal Transduction and Targeted Therapy 9 (1): 179. 29 July 2024

Membrane properties and coupling of macroglia in the optic nerve.
Kompier, N., Semtner, M., Walter, S., Kakabadze, N., Steinhäuser, C., Nolte, C. and Kettenmann, H.
Current Research in Neurobiology 7 : 100137. 21 August 2024

A high proportion of germline variants in pediatric chronic myeloid leukemia.
Krumbholz, M., Dolnik, A., Sträng, E., Ghete, T., Skambraks, S., Hutter, S., Simonis, A., Stegelmann, F., Suttorp, M., Horn, A.H.C., Sticht, H., Haferlach, T., Bullinger, L. and Metzler, M.
Molecular Cancer 23 (1): 206. 26 September 2024

Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts.
Lai, S., Wang, H., Bork, P., Chen, W.H. and Zhao, X.M.
Science Advances 10 (33): eadn3316. 16 August 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15 (1): 7027. 22 August 2024

CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83 (4): 499-507. 12 March 2024

Taste mapping: navigating the spatiotemporal link between diet and colorectal cancer.
Luo, Q., Liu, Y., Bi, M., Kuai, X., Tian, Q., Sun, Y. and Zhuang, S.
IEEE Access 12 : 17735 - 17747. 30 January 2024

Canonical and non-canonical localization of tight junction proteins during early murine cranial development.
Mak, S. and Hammes, A.
International Journal of Molecular Sciences 25 (3): 1426. 24 January 2024

An automated and fast sample preparation workflow for laser microdissection guided ultrasensitive proteomics.
Makhmut, A., Qin, D., Hartlmayr, D., Seth, A. and Coscia, F.
Molecular & Cellular Proteomics 23 (5): 100750. May 2024

Structure-based humanization of a therapeutic antibody for multiple myeloma.
Marino, S.F. and Daumke, O.
Journal of Molecular Medicine 102 (9): 1151-1161. September 2024

Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice.
Mattei, D., Ivanov, A., Hammer, J., Ugursu, B., Schalbetter, S., Richetto, J., Weber-Stadlbauer, U., Mueller, F., Scarborough, J., Wolf, S.A., Kettenmann, H., Wollscheid, B., Beule, D. and Meyer, U.
Brain, Behavior and Immunity 210 : 571-583. August 2024

Structure-based mapping of the histone-binding pocket of KDM4D using functionalized tetrazole and pyridine core compounds.
Małecki, P.H., Fassauer, G.M., Rüger, N., Schulig, L., Link, A., Krylova, O., Heinemann, U. and Weiss, M.S.
European Journal of Medicinal Chemistry 276 : 116642. 5 October 2024

Impact of the PI3Kalpha inhibitor alpelisib on everolimus resistance and somatostatin receptor expression in an orthotopic pancreatic NEC xenograft mouse model.
Mohan, A.M., Prasad, S., Schmitz-Peiffer, F., Lange, C., Lukas, M., Koziolek, E.J., Albrecht, J., Messroghli, D., Stein, U., Ilmer, M., Wang, K., Schober, L., Reul, A., Maurer, J., Friemel, J., Weber, A., Zuellig, R.A., Hantel, C., Fritsch, R., Reincke, M., Pacak, K., Grossman, A.B., Auernhammer, C.J., Beuschlein, F., Brenner, W., Beindorff, N. and Nölting, S.
Endocrine-Related Cancer 31 (1): e230041. January 2024

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4.
Mohd, S., Oder, A., Specker, E., Neuenschwander, M., von Kries, J.P. and Daumke, O.
PLoS ONE 19 (7): e0302704. 29 July 2024

AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.
Monjé, N., Dragomir, M.P., Sinn, B.V., Hoffmann, I., Makhmut, A., Simon, T., Kunze, C.A., Ihlow, J., Schmitt, W.D., Pohl, J., Piwonski, I., Marchenko, S., Keunecke, C., Calina, T.G., Tiso, F., Kulbe, H., Kreuzinger, C., Cacsire Castillo-Tong, D., Sehouli, J., Braicu, E.I., Denkert, C., Darb-Esfahani, S., Kübler, K., Capper, D., Coscia, F., Morkel, M., Horst, D., Sers, C. and Taube, E.T.
British Journal of Cancer 13 (8): 1249-1260. 3 May 2024

The contractile machines of the heart.
Morano, I.
Advances in Experimental Medicine and Biology 1441 : 417-433. 18 June 2024

The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue.
Morocho-Jaramillo, P.A., Kotlar-Goldaper, I., Zakarauskas-Seth, B.I., Purfürst, B., Filosa, A. and Sawamiphak, S.
Cell Reports 43 (3): 113955. 26 March 2024

Natural proteome diversity links aneuploidy tolerance to protein turnover.
Muenzner, J., Trébulle, P., Agostini, F., Zauber, H., Messner, C.B., Steger, M., Kilian, C., Lau, K., Barthel, N., Lehmann, A., Textoris-Taube, K., Caudal, E., Egger, A.S., Amari, F., De Chiara, M., Demichev, V., Gossmann, T.I., Mülleder, M., Liti, G., Schacherer, J., Selbach, M., Berman, J. and Ralser, M.
Nature 630 (8015): 149-157. 6 June 2024

Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A., Popp, O., Kunz, S., Sporbert, A., Jung, S., Penning, L.C., Fendler, A., Mertins, P. and Birchmeier, W.
PLoS ONE 19 (3): e0282938. 21 March 2024

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.
Müller, P., de la Cuesta-Zuluaga, J., Kuhn, M., Baghai Arassi, M., Treis, T., Blasche, S., Zimmermann, M., Bork, P., Patil, K.R., Typas, A., Garcia-Santamarina, S. and Maier, L.
Nature Protocols 19 (3): 668-699. March 2024

Fluorescent tools for the imaging of dopamine D2-like receptors.
Nagl, M., Moennich, D., Rosier, N., Schihada, H., Sirbu, A., Konar, N., Reyes-Resina, I., Navarro, G., Franco, R., Kolb, P., Annibale, P. and Pockes, S.
ChemBioChem 25 (2): e202300659. 15 January 2024

Topological reaction coordinate captures the folding transition state ensemble in a pierced lasso protein.
Noel, J.K. and Haglund, E.
Journal of Physical Chemistry B 128 (1): 117-124. 11 January 2024

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15 (1): 898. 6 February 2024

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y., Leney-Greene, M., Lynberg, M., Gabrielski, J.Q., Xu, X., Schwarz, B., Zheng, L., Balasubramaniyam, A., Ham, H., Chao, B., Zhang, Y., Matthews, H.F., Cui, J., Yao, Y., Kubo, S., Chanchu, J.M., Morawski, A.R., Cook, S.A., Jiang, P., Ravell, J.C., Cheng, Y.H., George, A., Faruqi, A., Pagalilauan, A.M., Bergerson, J.R.E., Ganesan, S., Chauvin, S.D., Aluri, J., Edwards-Hicks, J., Bohrnsen, E., Tippett, C., Omar, H., Xu, L., Butcher, G.W., Pascall, J., Karakoc-Aydiner, E., Kiykim, A., Maecker, H., Tezcan, İ., Esenboga, S., Heredia, R.J., Akata, D., Tekin, S., Kara, A., Kuloglu, Z., Unal, E., Kendirli, T., Dogu, F., Karabiber, E., Atkinson, T.P., Cochet, C., Filhol, O., Bosio, C.M., Davis, M.M., Lifton, R.P., Pearce, E.L., Daumke, O., Aytekin, C., Şahin, G.E., Aksu, A.Ü., Uzel, G., Koneti Rao, V., Sari, S., Boztug, K., Cagdas, D., Haskologlu, S., Ikinciogullari, A., Schwefel, D., Vilarinho, S., Baris, S., Ozen, A., Su, H.C. and Lenardo, M.J.
Nature Immunology 25 (2): 282-293. February 2024

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I.V., Oelen, R., Groot, H.E., Benjamins, J.W., Brambs, S., Kaiser, R., Gottschlich, A., Hoffmann, G.V., Eivers, L., Martinez-Navarro, A., Bruns, N., Stiller, S., Akgöl, S., Yue, K., Polewka, V., Escaig, R., Joppich, M., Janjic, A., Popp, O., Kobold, S., Petzold, T., Zimmer, R., Enard, W., Saar, K., Mertins, P., Huebner, N., van der Harst, P., Franke, L.H., van der Wijst, M.G.P., Massberg, S., Heinig, M., Nicolai, L. and Stark, K.
Nature Medicine 30 (6): 1696-1710. June 2024

The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice.
Pelz, L., Dossou, L., Kompier, N., Jüttner, R., Siemonsmeier, G., Meyer, N., Lowenstein, E.D., Lahmann, I., Kettenmann, H., Birchmeier, C. and Rathjen, F.G.
eNeuro 22 February 2024 (In Press)

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling.
Piletic, K., Kayvanjoo, A.H., Richter, F.C., Borsa, M., Lechuga-Vieco, A.V., Popp, O., Grenet, S., Ko, J.K.L., Zec, K., Kyriazi, M., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G. and Simon, A.K.
bioRxiv : 2024.09.17.613382. 17 September 2024

Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease.
Polovitskaya, M.M., Rana, T., Ullrich, K., Murko, S., Bierhals, T., Vogt, G., Stauber, T., Kubisch, C., Santer, R. and Jentsch, T.J.
Journal of Biological Chemistry 300 (7): 107437. July 2024

Elimusertib has antitumor activity in preclinical patient-derived pediatric solid tumor models.
Pusch, F.F., Dorado Garcia, H., Xu, R., Gürgen, D., Bei, Y., Brückner, L., Röefzaad, C., von Stebut, J., Bardinet, V., Chamorro Gonzalez, R., Eggert, A., Schulte, J.H., Hundsdörfer, P., Seifert, G., Haase, K., Schäfer, B.W., Wachtel, M., Kühl, A.A., Ortiz, M.V., Wengner, A.M., Scheer, M. and Henssen, A.G.
Molecular Cancer Therapeutics 23 (4): 507-519. 2 April 2024

Comparison of Xrn1 and Rat1 5′ → 3′ exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay.
Pérez-Ortín, J.E., Jordán-Pla, A., Zhang, Y., Moreno-García, J., Bassot, C., Barba-Aliaga, M., de Campos-Mata, L., Choder, M., Díez, J., Piazza, I., Pelechano, V. and García-Martínez, J.
Yeast 41 (7): 458-472. July 2024

Selection on synonymous sites: the unwanted transcript hypothesis.
Radrizzani, S., Kudla, G., Izsvák, Z. and Hurst, L.D.
Nature Reviews Genetics 25 (6): 431-448. June 2024

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger, E., Sapozhnikova, V., Ng, Y.L.D., Dolnik, A., Ziehm, M., Popp, O., Sträng, E., Kull, M., Grünschläger, F., Krüger, J., Benary, M., Müller, S., Gao, X., Murgai, A., Haji, M., Schmidt, A., Lutz, R., Nogai, A., Braune, J., Laue, D., Langer, C., Khandanpour, C., Bassermann, F., Döhner, H., Engelhardt, M., Straka, C., Hundemer, M., Beule, D., Haas, S., Keller, U., Einsele, H., Bullinger, L., Knop, S., Mertins, P. and Krönke, J.
Nature Cancer 5 (8): 1267-1284. August 2024

Cellular senescence: Neither irreversible nor reversible.
Reimann, M., Lee, S. and Schmitt, C.A.
Journal of Experimental Medicine 221 (4): e20232136. 1 April 2024

Functional and evolutionary significance of unknown genes from uncultivated taxa.
Rodríguez Del Río, Á., Giner-Lamia, J., Cantalapiedra, C.P., Botas, J., Deng, Z., Hernández-Plaza, A., Munar-Palmer, M., Santamaría-Hernando, S., Rodríguez-Herva, J.J., Ruscheweyh, H.J., Paoli, L., Schmidt, T.S.B., Sunagawa, S., Bork, P., López-Solanilla, E., Coelho, L.P. and Huerta-Cepas, J.
Nature 626 (7998): 377-384. 8 February 2024

Shedding light on the D1‐like receptors: a fluorescence‐based toolbox for visualization of the D1 and D5 receptors.
Rosier, N., Moennich, D., Nagl, M., Schihada, H., Sirbu, A., Konar, N., Reyes-Resina, I., Navarro, G., Franco, R., Kolb, P., Annibale, P. and Pockes, S.
ChemBioChem 25 (2): e202300658. 15 January 2024

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske, Y., Cappel, C., Cremer, N., Hoffmann, P., Koudelka, T., Tholey, A., Heinemann, U., Daumke, O. and Damme, M.
Nucleic Acids Research 52 (1): 370-384. 11 January 2024

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15 (1): 3146. 11 April 2024

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts.
Ruiz-Orera, J., Miller, D.C., Greiner, J., Genehr, C., Grammatikaki, A., Blachut, S., Mbebi, J., Patone, G., Myronova, A., Adami, E., Dewani, N., Liang, N., Hummel, O., Mücke, M.B., Hildebrandt, T.B., Fritsch, G., Schrade, L., Zimmermann, W.H., Kondova, I., Diecke, S., van Heesch, S. and Hübner, N.
Nature Cardiovascular Research 24 September 2024 (In Press)

Comprehensive characterization of the viscoelastic properties of bovine submaxillary mucin (BSM) hydrogels and the effect of additives.
Rulff, H., Schmidt, R.F., Wei, L.F., Fentker, K., Kerkhoff, Y., Mertins, P., Mall, M.A., Lauster, D. and Gradzielski, M.
Biomacromolecules 25 (7): 4014-4029. 8 July 2024

Targeted proteomics reveals quantitative differences in low-abundance glycosyltransferases of patients with congenital disorders of glycosylation.
Sakson, R., Beedgen, L., Bernhard, P., Alp, K.M., Lübbehusen, N., Röth, R., Niesler, B., Luzarowski, M., Shevchuk, O., Mayer, M.P., Thiel, C. and Ruppert, T.
International Journal of Molecular Sciences 25 (2): 1191. 18 January 2024

A novel developmental critical period of orexinergic signaling in the primary visual thalamus.
Sanetra, A.M., Jeczmien-Lazur, J.S., Pradel, K., Klich, J.D., Palus-Chramiec, K., Janik, M.E., Bajkacz, S., Izowit, G., Nathan, C., Piggins, H.D., Delogu, A., Belle, M.D.C., Lewandowski, M.H. and Chrobok, L.
iScience 27 (7): 110352. 19 July 2024

Discovery of antimicrobial peptides in the global microbiome with machine learning.
Santos-Júnior, C.D., Torres, M.D.T., Duan, Y., Rodríguez Del Río, Á., Schmidt, T.S.B., Chong, H., Fullam, A., Kuhn, M., Zhu, C., Houseman, A., Somborski, J., Vines, A., Zhao, X.M., Bork, P., Huerta-Cepas, J., de la Fuente-Nunez, C. and Coelho, L.P.
Cell 187 (14): 3761-3778.e16. 11 July 2024

TTF-1 status in early-stage lung adenocarcinoma is an independent predictor of relapse and survival superior to tumor grading.
Schallenberg, S., Dernbach, G., Dragomir, M.P., Schlachtenberger, G., Boschung, K., Friedrich, C., Standvoss, K., Ruff, L., Anders, P., Grohé, C., Randerath, W., Merkelbach-Bruse, S., Quaas, A., Heldwein, M., Keilholz, U., Hekmat, J.K., Rückert, C., Büttner, R., Horst, D., Klauschen, F. and Frost, N.
European Journal of Cancer 197 : 113474. January 2024

The proteomic composition and organization of constitutive heterochromatin in mouse tissues.
Schmidt, A., Zhang, H., Schmitt, S., Rausch, C., Popp, O., Chen, J., Cmarko, D., Butter, F., Dittmar, G., Lermyte, F. and Cardoso, M.C.
Cells 13 (2): 139. 11 January 2024

SPIRE: a Searchable, Planetary-scale mIcrobiome REsource.
Schmidt, T.S.B., Fullam, A., Ferretti, P., Orakov, A., Maistrenko, O.M., Ruscheweyh, H.J., Letunic, I., Duan, Y., Van Rossum, T., Sunagawa, S., Mende, D.R., Finn, R.D., Kuhn, M., Pedro Coelho, L. and Bork, P.
Nucleic Acids Research 52 (D1): D777-D783. 5 January 2024

Induction of circulating ABCB1 transcripts under platinum-based chemotherapy indicates poor prognosis and a bone micrometastatic phenotype in ovarian cancer patients.
Schwarz, F.M., Kuhlmann, J.D., Kämpfer, J., Klimova, A., Klotz, D.M., Freitag, L., Herrmann, P., Zinnow, V., Smith, J., Scheller, T., Walther, W., Wimberger, P. and Stein, U.
Molecular Cancer 23 (1): 174. 23 August 2024

Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction.
Semmler, L., Jeising, T., Huettemeister, J., Bathe-Peters, M., Georgoula, K., Roshanbin, R., Sander, P., Fu, S., Bode, D., Hohendanner, F., Pieske, B., Annibale, P., Schiattarella, G.G., Oeing, C.U. and Heinzel, F.R.
Acta Physiologica 240 (4): e14124. April 2024

Advancing research and treatment: an overview of clinical trials in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and future perspectives.
Seton, K.A., Espejo-Oltra, J.A., Giménez-Orenga, K., Haagmans, R., Ramadan, D.J. and Mehlsen, J.
Journal of Clinical Medicine 13 (2): 325. 6 January 2024

Huntingtin protein–protein interactions: From biology to therapeutic targets.
Silva Ramos, E., Greco, T.M., Cristea, I.M. and Wanker, E.E.
In: Huntington's Disease. Elsevier, New York, NY, USA, 159-186. ISBN pub.1168955041 16 February 2024

From regulation of cell fate decisions towards patient-specific treatments, insights from mechanistic models of signalling pathways.
Simon, M., Konrath, F. and Wolf, J.
Current Opinion in Systems Biology 39 : 100533. December 2024

Cell swelling enhances ligand-driven β-adrenergic signaling.
Sirbu, A., Bathe-Peters, M., Kumar, J.L.M, Inoue, A., Lohse, M.J. and Annibale, P.
Nature Communications 15 (1): 7822. 7 September 2024

Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O., Kirchner, M., Mertins, P., Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57 (9): 2140-2156.e10. 10 September 2024

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Stöber, M.C., Chamorro González, R., Brückner, L., Conrad, T., Wittstruck, N., Szymansky, A., Eggert, A., Schulte, J.H., Koche, R.P., Henssen, A.G., Schwarz, R.F. and Haase, K.
Cell Reports 43 (9): 114711. 24 September 2024

Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection.
Sun, G., Kropp, K.A., Kirchner, M., Plückebaum, N., Selich, A., Serrero, M., Dhingra, A., Cabrera, J.R., Ritter, B., Bauerfeind, R., Wyler, E., Landthaler, M., Schambach, A., Sodeik, B., Mertins, P. and Viejo-Borbolla, A.
mBio 15 (2): e0330823. 14 February 2024

EU-LIFE charter of independent life science research institutes.
Superti-Furga, G., Agostinho, M., Bury, J., Cook, S., Durinx, C., Ender, A., van Luenen, H., Lund, A.H., Medema, R.H., Miączyńska, M., Nickel, D., Pelicci, P.G., Puisieux, A., Ripatti, S., Sander, M., Schubeler, D., Serrano, L., Sommer, T., Sonne-Hansen, K., Tomančák, P., Vives, J., Vontas, J. and Bettencourt-Dias, M.
FEBS Letters 21 March 2024

Piezo2 voltage-block regulates mechanical pain sensitivity.
Sánchez-Carranza, O., Chakrabarti, S., Kühnemund, J., Schwaller, F., Bégay, V., García-Contreras, J.A., Wang, Lin and Lewin, G.R.
Brain 147 (10): 3487-3500. October 2024

Review: Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases.
Thiele, M., Villesen, I.., Niu, L., Johansen, S., Sulek, K., Nishijima, S., Van Espen, L., Keller, M., Israelsen, M., Suvitaival, T., de Zawadzki, A., Juel, H.B., Brol, M.J., Stinson, S.E., Huang, Y., Alvarez Silva, M.C., Kuhn, M., Anastasiadou, E., Leeming, D.J., Karsdal, M., Matthijnssens, J., Arumugam, M., Dalgaard, L.T., Legido-Quigley, C., Mann, M., Trebicka, J., Bork, P., Jensen, L.J., Hansen, T. and Krag, A.
Journal of Hepatology 81 (2): 345-359. August 2024

Immune response and metastasis-links between the metastasis driver MACC1 and cancer immune escape strategies.
Torke, S., Walther, W. and Stein, U.
Cancers 16 (7): 1330. 28 March 2024

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor.
Trepte, P., Secker, C., Olivet, J., Blavier, J., Kostova, S., Maseko, S.B., Minia, I., Silva Ramos, E., Cassonnet, P., Golusik, S., Zenkner, M., Beetz, S., Liebich, M.J., Scharek, N., Schutz, A., Sperling, M., Lisurek, M., Wang, Y., Spirohn, K., Hao, T., Calderwood, M.A., Hill, D.E., Landthaler, M., Choi, S.G., Twizere, J.C., Vidal, M. and Wanker, E.E.
Molecular Systems Biology 20 (4): 428-457. 2 April 2024

KCNQ5 controls perivascular adipose tissue–mediated vasodilation.
Tsvetkov, D., Schleifenbaum, J., Wang, Y., Kassmann, M., Polovitskaya, M.M., Ali, M., Schütze, S., Rothe, M., Luft, F.C., Jentsch, T.J. and Gollasch, M.
Hypertension 81 (3): 561-571. March 2024

Microglial sex differences in innate high anxiety and modulatory effects of minocycline.
Ugursu, B., Sah, A., Sartori, S., Popp, O., Mertins, P., Dunay, I.R., Kettenmann, H., Singewald, N. and Wolf, S.A.
Brain Behavior and Immunity 119 : 465-481. July 2024

Quantification of microglial engulfment of synaptic material using flow cytometry.
Ugursu, B. and Wolf, S.A.
Journal of Visualized Experiments (207) 31 May 2024

Editorial: The MACC1 network in cancer.
Walther, W., Siegel, F. and Stein, U.
Frontiers in Oncology 13 : 1343812. 5 July 2024

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho, A., Popp, O., Lenz, C., Pluska, L., Lambert, M., Dötsch, V., Mertins, P. and Sommer, T.
Life Science Alliance 7 (8): e202402740. August 2024

Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model.
Wang, F., Zhang, S., Sun, F., Chen, W., Liu, C., Dong, H., Cui, B., Li, L., Sun, C., Du, W., Liu, B., Fan, W., Deng, J., Schmitt, C.A., Wang, X. and Du, J.
Cancer Gene Therapy 31 (8): 1135-1150. August 2024

Structural insights into the activation mechanism of antimicrobial GBP1.
Weismehl, M., Chu, X., Kutsch, M., Lauterjung, P., Herrmann, C., Kudryashev, M. and Daumke, O.
EMBO Journal 43 (4): 615-636. 15 February 2024

Combining Data Independent Acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification.
Welter, A.S., Gerwien, M., Kerridge, R., Alp, K.M., Mertins, P. and Selbach, M.
Molecular & Cellular Proteomics : 100839. 11 September 2024 (In Press)

Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma.
Yalcin, F., Haneke, H., Efe, I.E., Kuhrt, L.D., Motta, E., Nickl, B., Flüh, C., Synowitz, M., Dzaye, O., Bader, M. and Kettenmann, H.
Acta Neuropathologica Communications 12 (1): 50. 2 April 2024

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature.
Yilmaz, M., Sever, B., Kutlu, Y., Gul, M., Okuducu, C., Tavli, S., Otsuka, M., Fujita, M., Haliloglu, T., Ciftci, H. and DeMirci, H.
bioRxiv : 2024.07.30.605796. 2 August 2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M., Pande, A., Margineanu, A., Lisewski, U., Purfürst, B., Zhu, H., Liang, L., Jia, S., Froehler, S., Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W., Raile, K., Sander, M. and Izsvák, Z.
iScience 27 (7): 110291. 19 July 2024

Neighborhood-level inequalities and influencing factors of COVID-19 incidence in berlin based on Bayesian spatial modelling.
Zhuang, S., Wolf, K., Schmitz, T., Roth, A., Sun, Y., Savaskan, N. and Lakes, T.
Sustainable Cities and Society 104 : 105301. May 2024

Die Herausforderung der Lupusnephritis: aktuelle Erkenntnisse und Behandlungsansätze.
Zimmermann, J. and Schreiber, A.
Nephrologie aktuell 28 (6): 248-256. July 2024

Avacopan in anti-neutrophil cytoplasmic autoantibodies–associated vasculitis in a real-world setting.
Zimmermann, J., Sonnemann, J., Jabs, W.J., Schönermarck, U., Vielhauer, V., Bieringer, M., Schneider, U., Kettritz, R. and Schreiber, A.
Kidney International Reports 9 (9): 2803-2808. September 2024

2023

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T., Stolzenberg, S., Sticht, J., Wieczorek, M., Roske, Y., Günther, M., Dähn, S., Boesen, B.B., Calvo, M.M., Biese, C., Kuppler, F., Medina-García, Á., Álvaro-Benito, M., Höfer, T., Noé, F. and Freund, C.
Nature Chemical Biology 19 (10): 1196-1204. October 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Aguirre, T., Hostachy, S., Dornan, G.L., Neuenschwander, M., Seyffarth, C., Haucke, V., Schütz, A., von Kries, J.P. and Fiedler, D.
eLife 21 : RP88982. 16 October 2023

The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
Ahmed, S.M., Ragunathan, P., Shin, J., Peter, S., Kleissle, S., Neuenschwander, M., Schäfer, R., von Kries, J.P., Grüber, G. and Dröge, P.
FEBS Letters 597 (15): 1977-1988. August 2023

Clinically relevant glioblastoma patient-derived xenograft models to guide drug development and identify molecular signatures.
Alcaniz, J., Winkler, L., Dahlmann, M., Becker, M., Orthmann, A., Haybaeck, J., Krassnig, S., Skofler, C., Kratzsch, T., Kuhn, S.A., Jödicke, A., Linnebacher, M., Fichtner, I., Walther, W. and Hoffmann, J.
Frontiers in Oncology 13 : 1129627. 11 April 2023

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Alteen, M.G., Deme, J.C., Alvarez, C.P., Loppnau, P., Hutchinson, A., Seitova, A., Chandrasekaran, R., Silva Ramos, E., Secker, C., Alqazzaz, M., Wanker, E.E., Lea, S.M., Arrowsmith, C.H. and Harding, R.J.
Structure 31 (9): 1121-1131.e6. 7 September 2023

On multistability and constitutive relations of cell motion on Fibronectin lanes.
Amiri, B., Heyn, J.C.J., Schreiber, C., Rädler, J.O. and Falcke, M.
Biophysical Journal 122 (5): 753-766. 7 March 2023

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S.K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J.E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M.T., Hoyles, L., Alves, R., Helft, G., Isnard, R., Køber, L., Coelho, L.P., Rouault, C., Gauguier, D., Gøtze, J.P., Prifti, E., Froguel, P., Zucker, J.D., Bäckhed, F., Vestergaard, H., Hansen, T., Oppert, J.M., Blüher, M., Nielsen, J., Raes, J., Bork, P., Yaqoob, M.M., Stumvoll, M., Pedersen, O., Ehrlich, S.D., Clément, K. and Dumas, M.E.
Nature Communications 14 (1): 5843. 20 September 2023

Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14 (1): 6543. 17 October 2023

Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
Bech, J.M., Terkelsen, T., Bartels, A.S., Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G.I., Fang, X., Mann, M. and Moreira, J.M.A.
Gastroenterology 165 (1): 121-132.e5. July 2023

Establishment and thorough characterization of xenograft (PDX) models derived from patients with pancreatic cancer for molecular analyses and chemosensitivity testing.
Behrens, D., Pfohl, U., Conrad, T., Becker, M., Brzezicha, B., Büttner, B., Wagner, S., Hallas, C., Lawlor, R., Khazak, V., Linnebacher, M., Wartmann, T., Fichtner, I., Hoffmann, J., Dahlmann, M. and Walther, W.
Cancers 15 (24): 5753. 8 December 2023

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15 (1): 50. 20 July 2023

Combining metabolic pulse labeling and quantitative proteomics to monitor protein synthesis upon viral infection.
Bogdanow, B., Katsimani, N., Liu, F. and Selbach, M.
Methods in Molecular Biology 2610 : 149-165. 2023

Metastasis associated in colorectal cancer 1 (MACC1) mRNA expression is enhanced in sporadic vestibular schwannoma and correlates to deafness.
Breun, M., Flock, K., Feldheim, J., Nattmann, A., Monoranu, C.M., Herrmann, P., Ernestus, R.I., Löhr, M., Hagemann, C. and Stein, U.
Cancers 15 (16): 4089. 14 August 2023

Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest, F., Noerenberg, D., Hennch, C., Yoshida, K., Hablesreiter, R., Nimo, J., Sasca, D., Kirchner, M., Mansouri, L., Inoue, Y., Wiegand, L., Staiger, A.M., Casadei, B., Korkolopoulou, P., Weiner, J., Lopez-Guillermo, A., Warth, A., Schneider, T., Nagy, Á., Klapper, W., Hummel, M., Kanellis, G., Anagnostopoulos, I., Mertins, P., Bullinger, L., Rosenquist, R., Vassilakopoulos, T.P., Ott, G., Ogawa, S. and Damm, F.
Leukemia 37 (11): 2237-2249. November 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R., Conrad, T., Stöber, M.C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., Kasack, K., Brückner, L., van Leen, E., Helmsauer, K., Dorado Garcia, H., Stefanova, M.E., Hung, K.L., Bei, Y., Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y., Deubzer, H.E., Sauer, S., Eggert, A., Schulte, J.H., Schwarz, R.F., Haase, K., Koche, R.P. and Henssen, A.G.
Nature Genetics 55 (5): 880-890. May 2023

Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging.
Chang, S.Y.S., Dijkman, P.M., Wiessing, S.A. and Kudryashev, M.
Scientific Reports 13 : 11523. 17 July 2023

Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis.
Chen, J., Alexander, T., Walter-Rittel, T., Ziagaki, A. and Siffrin, V.
Therapeutic Advances in Neurological Disorders 16 : 17562864231182519. 2023

TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages.
Chen, X., Zhao, Y., Huang, Y., Zhu, K., Zeng, F., Zhao, J., Zhang, H., Zhu, X., Kettenmann, H. and Xiang, X.
Glia 71 (11): 2679-2695. November 2023

Mechanisms of substrate processing during ER-associated protein degradation.
Christianson, J.C., Jarosch, E. and Sommer, T.
Nature Reviews Molecular Cell Biology 24 (11): 777-796. November 2023

Gentle ions for cryo-FIB milling.
Chu, X. and Kudryashev, M.
Structure 31 (10): 1147-1148. 5 October 2023

HMGXB4 targets Sleeping Beauty transposition to germinal stem cells.
Devaraj, A., Singh, M., Narayanavari, S.A., Yong, G., Chen, J., Wang, J., Becker, M., Walisko, O., Schorn, A., Cseresznyés, Z., Raskó, T., Radscheit, K., Selbach, M., Ivics, Z. and Izsvak, Z.
International Journal of Molecular Sciences 24 (8): 7283. 14 April 2023

N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness.
Dong, Hongliang, Zeng, Lili, Chen, Weiwei, Zhang, Qian, Wang, Fei, Wu, Yan, Cui, Bingjie, Qi, Jingjing, Zhang, Xin, Liu, Cuilan, Deng, Jiong, Yu, Y., Schmitt, C.A. and Du, Jing
Cell Death Discovery 9 (1): 149. 6 May 2023

Targeting B cells and microglia in multiple sclerosis with Bruton tyrosine kinase inhibitors: a review.
Dybowski, S., Torke, S. and Weber, M.S.
JAMA Neurology 80 (4): 404-414. 1 April 2023

Mutations in phosphodiesterase 3A (PDE3A) cause hypertension without cardiac damage.
Ercu, M., Walter, S. and Klussmann, E.
Hypertension 80 (6): 1171-1179. June 2023

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H., Schöberl, F., Giurgiu, M., Leal Silva, R.M., Scholz, V., Scharf, F., Wendlandt, M., Kleinle, S., Deschauer, M., Nübling, G., Heide, W., Babacan, S.S., Schneider, C., Neuhann, T., Hahn, K., Schoser, B., Holinski-Feder, E., Wolf, D.A. and Abicht, A.
Brain 146 (5): 1831-1843. May 2023

Thioester and oxyester linkages in the ubiquitin system.
Ferri-Blazquez, A., Jarosch, E. and Sommer, T.
Methods in Molecular Biology 2602 : 3-18. 2023

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N., Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A., André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M., Cui, C., Daumke, O., Del Bel, K.L., Eibel, H., Feng, X., Franke, V., Gebhardt, J.C.M., Götz, A., Grunwald, S., Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M., Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W., Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S., Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8 (79): eade7953. January 2023

Cesium activates the neurotransmitter receptor for glycine.
Fricke, S., Harnau, M., Hetsch, F., Liu, H., Leonhard, J., Eylmann, A., Knauff, P., Sun, H., Semtner, M. and Meier, J.C.
Frontiers in Molecular Neuroscience 16 : 1018530. 22 May 2023

Modeling IP(3)-induced Ca(2+) signaling based on its interspike interval statistics.
Friedhoff, V.N., Lindner, B. and Falcke, M.
Biophysical Journal 122 (13): 2818-2831. 11 July 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

Protein biomarkers in blood reflect the interrelationships between stroke outcome, inflammation, coagulation, adhesion, senescence and cancer.
Fuellen, G., Walter, U., Henze, L., Böhmert, J., Palmer, D., Lee, S., Schmitt, C.A., Rudolf, H. and Kowald, A.
Cellular and Molecular Neurobiology 43 (4): 1413-1424. May 2023

proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes.
Fullam, A., Letunic, I., Schmidt, T.S.B., Ducarmon, Q.R., Karcher, N., Khedkar, S., Kuhn, M., Larralde, M., Maistrenko, O.M., Malfertheiner, L., Milanese, A., Rodrigues, J.F.M., Sanchis-López, C., Schudoma, C., Szklarczyk, D., Sunagawa, S., Zeller, G., Huerta-Cepas, J., von Mering, C., Bork, P. and Mende, D.R.
Nucleic Acids Research 51 (D1): D760-D766. 6 January 2023

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.
Geng, S., Paul, F., Kowalczyk, I., Raimundo, S., Sporbert, A., Mamo, T.M. and Hammes, A.
Frontiers in Cell and Developmental Biology 11 : 1173688. 7 April 2023

Quantitative morphological analysis of the T-tubular network of ventricular cardiomyocytes using novel image processing tools.
Georgoula, K., Sage, D. and Annibale, P.
In: European Conferences on Biomedical Optics 2023, 25-29 June 2023, Munich, Germany. 11 August 2023

Proteostasis in T cell aging.
Gressler, A.E., Leng, H., Zinecker, H. and Simon, A.K.
Seminars in Immunology 70 : 101838. November 2023

Sex-specific microglia state in the neuroligin-4 knock-out mouse model of autism spectrum disorder.
Guneykaya, D., Ugursu, B., Logiacco, F., Popp, O., Feiks, M.A., Meyer, N., Wendt, S., Semtner, M., Cherif, F., Gauthier, C., Madore, C., Yin, Z., Çınar, Ö., Arslan, T., Gerevich, Z., Mertins, P., Butovsky, O., Kettenmann, H. and Wolf, S.A.
Brain Behavior and Immunity 111 : 61-75. July 2023

Enhanced biosafety of the Sleeping Beauty transposon system by using mRNA as source of transposase to efficiently and stably transfect retinal pigment epithelial cells.
Harmening, N., Johnen, S., Izsvák, Z., Ivics, Z., Kropp, M., Bascuas, T., Walter, P., Kreis, A., Pajic, B. and Thumann, G.
Biomolecules 13 (4): 658. 7 April 2023

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Heynen, G.J.J.E., Baumgartner, F., Heider, M., Patra, U., Holz, M., Braune, J., Kaiser, M., Schäffer, I., Bamopoulos, S.A., Ramberger, E., Murgai, A., Ng, Y.L.D., Demel, U.M., Laue, D., Liebig, S., Krüger, J., Janz, M., Nogai, A., Schick, M., Mertins, P., Müller, S., Bassermann, F., Krönke, J., Keller, U. and Wirth, M.
Blood Advances 7 (4): 469-481. 28 February 2023

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.
Hoffmann, J., Hanß, S., Kraus, M., Schaller, J., Schäfer, C., Stahl, D., Anker, S.D., Anton, G., Bahls, T., Blankenberg, S., Blumentritt, A., Boldt, L.H., Cordes, S., Desch, S., Doehner, W., Dörr, M., Edelmann, F., Eitel, I., Endres, M., Engelhardt, S., Erdmann, J., Eulenburg, K., Falk, V., Felix, S.B., Frank, D., Franke, T., Frey, N., Friede, T., Geidel, L., Germans, L., Grabmaier, U., Halle, M., Hausleiter, J., Jakobi, V., Jebran, A.F., Jobs, A., Kääb, S., Karakas, M., Katus, H.A., Klatt, A., Knosalla, C., Krebser, J., Landmesser, U., Lee, M., Lehnert, K., Lesser, S., Leyh, K., Lorbeer, R., Mach-Kolb, S., Meder, B., Nagel, E., Nolte, C.H., Parwani, A.S., Petersmann, A., Puls, M., Rau, H., Reiser, M., Rienhoff, O., Scharfe, T., Schattschneider, M., Scheel, H., Schnabel, R.B., Schuster, A., Schmitt, B., Seidler, T., Seiffert, M., Stähli, B.E., Stas, A., Stocker, T.J., von Stülpnagel, L., Thiele, H., Wachter, R., Wakili, R., Weis, T., Weitmann, K., Wichmann, H.E., Wild, P., Zeller, T., Hoffmann, W., Zeisberg, E.M., Zimmermann, W.H., Krefting, D., Kühne, T., Peters, A., Hasenfuß, G., Massberg, S., Sommer, T., Dimmeler, S., Eschenhagen, T. and Nauck, M.
Clinical Research in Cardiology 112 (7): 923-941. July 2023

Monitoring mitochondrial translation by pulse SILAC.
Imami, K., Selbach, M. and Ishihama, Y.
Journal of Biological Chemistry 299 (2): 102865. February 2023

Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 11 (3): e006784. 14 March 2023

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Jordan, P., Costa, A., Specker, E., Popp, O., Volkamer, A., Piske, R., Obrusnik, T., Kleissle, S., Stuke, K., Rex, A., Neuenschwander, M., von Kries, J.P., Nazare, M., Mertins, P., Kettenmann, H. and Wolf, S.A.
PLoS ONE 18 (2): e0278325. 6 February 2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Campos, J., Mayer, C., D Este, E., Möbius, W., Cordano, C., Pröbstel, A.K., Gharagozloo, M., Zulji, A., Narayanan Naik, V., Delank, A.K., Cerina, M., Müntefering, T., Lerma-Martin, C., Sonner, J.K., Sin, J.H., Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K.C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T.J., Engelhardt, M., Budde, T., Nave, K.A., Calabresi, P.A., Friese, M.A., Green, A.J., Acuna, C., Rowitch, D.H., Meuth, S.G. and Schirmer, L.
Journal of Clinical Investigation 133 (7): e164223. 3 April 2023

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors.
Kayser, C., Melkes, B., Derieux, C. and Bock, A.
Current Opinion in Pharmacology 71 : 102384. August 2023

Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data.
Kazemi, S., Lopata, A., Kniss, A., Pluska, L., Güntert, P., Sommer, T., Prisner, T.F., Collauto, A. and Dötsch, V.
Journal of Biomolecular NMR 77 (5-6): 261-269. December 2023

The central role of DNA damage in immunosenescence.
Kell, L., Simon, A.K., Alsaleh, G. and Cox, L.S.
Frontiers in Aging 4 : 1202152. 3 July 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24 (3): 414-422. March 2023

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
Kennedy, K.M., de Goffau, M.C., Perez-Muñoz, M.E., Arrieta, M.C., Bäckhed, F., Bork, P., Braun, T., Bushman, F.D., Dore, J., de Vos, W.M., Earl, A.M., Eisen, J.A., Elovitz, M.A., Ganal-Vonarburg, S.C., Gänzle, M.G., Garrett, W.S., Hall, L.J., Hornef, M.W., Huttenhower, C., Konnikova, L., Lebeer, S., Macpherson, A.J., Massey, R.C., McHardy, A.C., Koren, O., Lawley, T.D., Ley, R.E., O'Mahony, L., O'Toole, P.W., Pamer, E.G., Parkhill, J., Raes, J., Rattei, T., Salonen, A., Segal, E., Segata, N., Shanahan, F., Sloboda, D.M., Smith, G.C.S., Sokol, H., Spector, T.D., Surette, M.G., Tannock, G.W., Walker, A.W., Yassour, M. and Walter, J.
Nature 613 (7945): 639-649. 26 January 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Many kinases for controlling the water channel aquaporin‐2.
Kharin, A. and Klussmann, E.
Journal of Physiology 602 (13): 3025-3039. 1 July 2023

Aquaporin-2 is not alone.
Klussmann, E.
Kidney International 103 (3): 458-460. March 2023

Resolving crosstalk between signaling pathways using mathematical modeling and time-resolved single cell data.
Konrath, F., Loewer, A. and Wolf, J.
Methods in Molecular Biology 2634 : 267-284. 2023

A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1.
Konrath, F., Willenbrock, M., Busse, D., Scheidereit, C. and Wolf, J.
iScience 26 (10): 107917. 20 October 2023

Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria.
Kourpa, A., Schulz, A., Mangelsen, E., Kaiser-Graf, D., Koppers, N., Stoll, M., Rothe, M., Bader, M., Purfürst, B., Kunz, S., Gladytz, T., Niendorf, T., Bachmann, S., Mutig, K., Bolbrinker, J., Panakova, D. and Kreutz, R.
Hypertension 80 (4): 771-782. April 2023

Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia.
Kuhrt, L.D., Motta, E., Elmadany, N., Weidling, H., Fritsche-Guenther, R., Efe, I.E., Cobb, O., Chatterjee, J., Boggs, L.G., Schnauß, M., Diecke, S., Semtner, M., Anastasaki, C., Gutmann, D.H. and Kettenmann, H.
Disease Models & Mechanisms 16 (12): dmm049861. December 2023

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J., Theisen, S., Dartsch, J., Fritsche-Guenther, R., Kirchner, M., Obermayer, B., Bauer, A., Kahlert, A.K., Rothe, M., Beule, D., Heuser, A., Mertins, P., Kirwan, J.A., Berndt, N., MacRae, C.A., Hubner, N. and Klaassen, S.
Cardiovascular Research 119 (18): 2902-2916. December 2023

Enterotypes of the human gut mycobiome.
Lai, S., Yan, Y., Pu, Y., Lin, S., Qiu, J.G., Jiang, B.H., Keller, M.I., Wang, M., Bork, P., Chen, W.H., Zheng, Y. and Zhao, X.M.
Microbiome 11 (1): 179. 11 August 2023

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M., Temel, D., Ohlendorf, E., Zirngibl, F., Materne, B., Oevermann, L., Deubzer, H.E., Henssen, A.G., Künkele, A., Hundsdörfer, P., von Bernuth, H., Pruß, A., Eggert, A., von Stackelberg, A., Lang, P. and Schulte, J.H.
Haematologica 108 (1): 267-272. January 2023

Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li, B., Zeis, P., Zhang, Y., Alekseenko, A., Fürst, E., Sanchez, Y.P., Lin, G., Tekkedil, M.M., Piazza, I., Steinmetz, L.M. and Pelechano, V.
Nature Communications 14 (1): 910. 17 February 2023

A weak-labelling and deep learning approach for in-focus object segmentation in 3D widefield microscopy.
Li, R., Kudryashev, M. and Yakimovich, A.
Scientific Reports 13 (1): 12275. 28 July 2023

SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.
Li, Y., Dörmann, N., Brinschwitz, B., Kny, M., Martin, E., Bartels, K., Li, N., Giri, P.V., Schwanz, S., Boschmann, M., Hille, S., Fielitz, B., Wollersheim, T., Grunow, J., Felix, S.B., Weber-Carstens, S., Luft, F.C., Müller, O.J. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 14 (4): 1721-1736. August 2023

SLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle.
Liu, H., Arsiè, R., Schwabe, D., Schilling, M., Minia, I., Alles, J., Boltengagen, A., Kocks, C., Falcke, M., Friedman, N., Landthaler, M. and Rajewsky, N.
Molecular Systems Biology 19 (10): e11427. 12 October 2023

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels.
Liu, H., Polovitskaya, M.M., Yang, L., Li, M., Li, H., Han, Z., Wu, J., Zhang, Q., Jentsch, T.J. and Liao, J.
Cell Reports 42 (8): 112926. 29 August 2023

Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease.
Liu, T. and Klussmann, E.
Current Opinion in Pharmacology 71 : 102392. August 2023

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A., Latorre, J., Serena-Maione, A., Espadas, I., Caballano-Infantes, E., Moreno-Navarrete, J.M., Oliveras-Cañellas, N., Ricart, W., Malagón, M.M., Martin-Montalvo, A., Birchmeier, W., Szymanski, W., Graumann, J., Gómez-Serrano, M., Sommariva, E., Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14 (1): 5106. 22 August 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T., Belabed, H., Kücükdisli, M., Metag, J., Roske, Y., Prokofeva, P., Ohashi, Y., Horatscheck, A., Cirillo, D., Krauss, M., Schmied, C., Neuenschwander, M., von Kries, J.P., Médard, G., Kuster, Be., Perisic, O., Williams, R.L., Daumke, O., Payrastre, B., Severin, S., Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic.
Logiacco, F., Grzegorzek, L.C., Cordell, E.C., Popp, O., Mertins, P., Gutmann, D.H., Kettenmann, H. and Semtner, M.
Acta Neuropathologica Communications 11 (1): 36. 9 March 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

A framework for ultra-low-input spatial tissue proteomics.
Makhmut, A., Qin, D., Fritzsche, S., Nimo, J., König, J. and Coscia, F.
Cell Systems 14 (11): 1002-1014. 15 November 2023

Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Malinovska, L., Cappelletti, V., Kohler, D., Piazza, I., Tsai, T.H., Pepelnjak, M., Stalder, P., Dörig, C., Sesterhenn, F., Elsässer, F., Kralickova, L., Beaton, N., Reiter, L., de Souza, N., Vitek, O. and Picotti, P.
Nature Protocols 18 : 659-682. 16 March 2023

Replicative aging impedes stress-induced assembly of a key human protein disaggregase.
Mathangasinghe, Y., Alberts, N., Rosado, C.J., Cox, D., Payne, N.L., Ormsby, A.R., Alp, K.M., Sakson, R., Uthishtran, S., Ruppert, T., Arumugam, S., Hatters, D.M., Kampinga, H.H. and Nillegoda, N.B.
bioRxiv : 2022.06.25.497591. 8 January 2023

The IgCAM CAR regulates gap junction-mediated coupling on embryonic cardiomyocytes and affects their beating frequency.
Matthaeus, C., Jüttner, R., Gotthardt, M. and Rathjen, F.G.
Life 13 (1): 14. January 2023

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier, M., Gupta, M., Akgül, S., McDougall, M., Imhof, T., Nikodemus, D., Reuten, R., Moya-Torres, A., To, V., Ferens, F., Heide, F., Padilla-Meier, G.P., Kukura, P., Huang, W., Gerisch, B., Mörgelin, M., Poole, K., Antebi, A., Koch, M. and Stetefeld, J.
Nature Communications 14 (1): 1226. 3 March 2023

Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S., von Kügelgen, N., Dantsuji, S., Ron, M., Breimann, L., Baranovskii, A., Lödige, I., Kirchner, M., Fischer, M., Zerna, N., Bujanic, L., Mertins, P., Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26 (3): 394-405. March 2023

Inflammatory cytokines associated with multiple sclerosis directly induce alterations of neuronal cytoarchitecture in human neurons.
Meyer-Arndt, L., Kerkering, J., Kuehl, T., Gil Infante, A., Paul, F., Rosiewicz, K.S., Siffrin, V. and Alisch, M.
Journal of Neuroimmune Pharmacology 18 (1-2): 145-159. June 2023

Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C., Lisowski, P., Genehr, C., Wanker, E.E., Priller, J., Prigione, A. and Diecke, S.
Stem Cell Research 68 : 103056. April 2023

CRISPR/Cas9 screen in gastric cancer patient-derived organoids reveals KDM1A-NDRG1 axis as a targetable vulnerability.
Mircetic, J., Camgöz, A., Abohawya, M., Ding, L., Dietzel, J., Tobar, S.G., Paszkowski-Rogacz, M., Seidlitz, T., Schmäche, T., Mehnert, M.C., Sidorova, O., Weitz, J., Buchholz, F. and Stange, D.E.
Small Methods 7 (6): e2201605. 20 June 2023

Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.
Montag, D., Pelz, L. and Rathjen, F.G.
PLoS ONE 18 (1): e0280133. 6 January 2023

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors.
Mucka, P., Lindemann, P., Bosco, B., Willenbrock, M., Radetzki, S., Neuenschwander, M., Brischetto, C., von Kries, J.P., Nazaré, M. and Scheidereit, C.
Cell Chemical Biology 30 (10): 1303-1312.e3. 19 October 2023

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees, T.A., Wang, N., Adamek, P., Zeitzschel, N., Verkest, C., La Porta, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Begay, V., Lee, Y.J., Tappe-Theodor, A., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
Nature Communications 14 (1): 1899. 5 April 2023

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Neuschulz, A., Bakina, O., Badillo Lisakowski, V., Olivares-Chauvet, P., Conrad, T., Gotthardt, M., Kettenmann, H. and Junker, J.P.
Molecular Systems Biology 19 (2): e11147. 10 February 2023

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology.
Nguyen, L.T., Zimmermann, K., Kowenz-Leutz, E., Lim, R., Hofstätter, M., Mildner, A. and Leutz, A.
Stem Cell Reports 28 December 2023

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
Nurminen, A., Jaatinen, S., Taavitsainen, S., Högnäs, G., Lesluyes, T., Ansari-Pour, N., Tolonen, T., Haase, K., Koskenalho, A., Kankainen, M., Jasu, J., Rauhala, H., Kesäniemi, J., Nikupaavola, T., Kujala, P., Rinta-Kiikka, I., Riikonen, J., Kaipia, A., Murtola, T., Tammela, T.L., Visakorpi, T., Nykter, M., Wedge, D.C., Van Loo, P. and Bova, G.S.
Genome Medicine 15 (1): 82. 12 October 2023

Daratumumab for the treatment of refractory ANCA-associated vasculitis.
Ostendorf, L., Burns, M., Wagner, D.L., Enghard, P., Amann, K., Mei, H., Eckardt, K.U., Seelow, E. and Schreiber, A.
RMD Open 9 (1): e002742. 10 January 2023

Using PrISMa to reveal the interactome of the human claudins family.
Perez-Hernandez, D., Suarez-Artiles, L., Jones, M.S.O. and Dittmar, G.
STAR Protocols 4 (4): 102549. 15 December 2023

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S., Roske, Y., Rami, B., Phan, M.H.Q., Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120 (4): e2208941120. 24 January 2023

SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A., López-Cayuqueo, K.I., Scherer, N., Wuttke, M., Wernstedt, A., González Fassrainer, D., Smith, D.E., van de Kamp, J.M., Ziegeler, K., Eckardt, K.U., Luft, F.C., Aronson, P.S., Köttgen, A., Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133 (3): e161849. 1 February 2023

H4K20me3 upregulated by reactive oxygen species is associated with tumor progression and poor prognosis in patients with hepatocellular carcinoma.
Phoyen, S., Sanpavat, A., Ma-on, C., Stein, U., Hirankarn, N., Tangkijvanich, P., Jindatip, D., Whongsiri, P. and Boonla, C.
Heliyon 9 (12): e22589. December 2023

Autophagy orchestrates the crosstalk between cells and organs.
Piletic, K., Alsaleh, G. and Simon, A.K.
EMBO Reports 24 (9): e57289. 6 September 2023

Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks.
Proft, S., Leiz, J., Heinemann, U., Seelow, D., Schmidt-Ott, K.M. and Rutkiewicz, M.
BMC Genomics 24 (1): 736. 4 December 2023

Cryo-EM captures early ribosome assembly in action.
Qin, B., Lauer, S.M., Balke, A., Vieira-Vieira, C.H., Bürger, J., Mielke, T., Selbach, M., Scheerer, P., Spahn, C.M.T. and Nikolay, R.
Nature Communications 14 (1): 898. 17 February 2023

Retrotransposon: a versatile player in human preimplantation development and health.
Qu, Y., Izsvák, Z. and Wang, J.
Life Medicine 2 (1): 1-3. February 2023

An integrate-and-fire approach to Ca(2+) signaling. Part II: Cumulative refractoriness.
Ramlow, L., Falcke, M. and Lindner, B.
Biophysical Journal 122 (24): 4710-4729. 19 December 2023

An integrate-and-fire approach to Ca(2+) signaling. Part I: Renewal model.
Ramlow, L., Falcke, M. and Lindner, B.
Biophysical Journal 122 (4): 713-736. 21 February 2023

The IgSF cell adhesion protein CLMP and congenital short bowel syndrome (CSBS).
Rathjen, F.G. and Jüttner, R.
International Journal of Molecular Sciences 24 (6): 5719. 16 March 2023

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch, T., Snajder, R., Leger, A., Simovic, M., Giurgiu, M., Villacorta, L., Henssen, A.G., Fröhling, S., Stegle, O., Birney, E., Bonder, M.J., Ernst, A. and Korbel, J.O.
Cell Genomics 3 (4): 100281. 12 April 2023

Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Richter, F.C., Friedrich, M., Kampschulte, N., Piletic, K., Alsaleh, G., Zummach, R., Hecker, J., Pohin, M., Ilott, N., Guschina, I., Wideman, S.K., Johnson, E., Borsa, M., Hahn, P., Morriseau, C., Hammock, B.D., Schipper, H.S., Edwards, C.M, Zechner, R., Siegmund, B., Weidinger, C., Schebb, N.H., Powrie, F. and Simon, A.K.
EMBO Journal 42 (6): e112202. 15 March 2023

Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E., Planas-Fèlix, M., Burkert, M., Puiggròs, M., Toedling, J., Thiessen, N., Blanc, E., Szymansky, A., Hertwig, F., Ishaque, N., Beule, D., Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F., Haase, K., Schulte, J.H. and Henssen, A.G.
Cell Genomics 3 (10): 100402. 11 October 2023

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.
Rosiewicz, K.S., Muinjonov, B., Kunz, S., Radbruch, H., Chen, J., Jüttner, R., Kerkering, J., Ucar, J., Crowley, T., Wielockx, B., Paul, F., Alisch, M. and Siffrin, V.
Glia 71 (8): 2024-2044. August 2023

TapA acts as specific chaperone in TasA filament formation by strand complementation.
Roske, Y., Lindemann, F., Diehl, A., Cremer, N., Higman, V.A., Schlegel, B., Leidert, M., Driller, K., Turgay, K., Schmieder, P., Heinemann, U. and Oschkinat, H.
Proceedings of the National Academy of Sciences of the United States of America 120 (17): e2217070120. 25 April 2023

The potential of cross-linking mass spectrometry in the development of protein-protein interaction modulators.
Ruwolt, M., Piazza, I. and Liu, F.
Current Opinion in Structural Biology 82 : 102648. October 2023

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83 (6): 994-1011.e18. 16 March 2023

Proglucagon signalling in the rat dorsomedial hypothalamus - physiology and high-fat diet-mediated alterations.
Sanetra, A M., Palus-Chramiec, K., Chrobok, L., Jeczmien-Lazur, J.S., Klich, J.D. and Lewandowski, M.H.
Molecular and Cellular Neuroscience 126 : 103873. September 2023

Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis.
Schaupp, L., Addante, A., Völler, M., Fentker, K., Kuppe, A., Bardua, M., Duerr, J., Piehler, L., Röhmel, J., Thee, S., Kirchner, M., Ziehm, M., Lauster, D., Haag, R., Gradzielski, M., Stahl, M., Mertins, P., Boutin, S., Graeber, S.Y. and Mall, M.A.
European Respiratory Journal 62 (2): 2202153. 1 August 2023

Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14 (1): 6947. 7 November 2023

COVID-19 and cellular senescence.
Schmitt, C.A., Tchkonia, T., Niedernhofer, L.J., Robbins, P.D., Kirkland, J.L. and Lee, S.
Nature Reviews Immunology 23 (4): 251-263. April 2023

Cantharidin and its analogue norcantharidin inhibit metastasis-inducing genes S100A4 and MACC1.
Schöpe, P.C., Zinnow, V., Ishfaq, M.A., Smith, J., Herrmann, P., Shoemaker, R.H., Walther, W. and Stein, U.
International Journal of Molecular Sciences 24 (2): 1179. 7 January 2023

A concise guide to choosing suitable gene expression systems for recombinant protein production.
Schütz, A., Bernhard, F., Berrow, N., Buyel, J.F., Ferreira-da-Silva, F., Haustraete, J., van den Heuvel, J., Hoffmann, J.E., de Marco, A., Peleg, Y., Suppmann, S., Unger, T., Vanhoucke, M., Witt, S. and Remans, K.
STAR Protocols 4 (4): 102572. 15 December 2023

Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists.
Secker, C., Fackeldey, K., Weber, M., Ray, S., Gorgulla, C. and Schütte, C.
Journal of Cheminformatics 15 (1): 85. 19 September 2023

The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Secker, C., Motzny, A.Y., Kostova, S., Buntru, A., Helmecke, L., Reus, L., Steinfort, R., Brusendorf, L., Boddrich, A., Neuendorf, N., Diez, L., Schmieder, P., Schulz, A., Czekelius, C. and Wanker, E.E.
Journal of Neurochemistry 166 (2): 294-317. 18 July 2023

Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104 (2): 388-393. August 2023

GIPC1 regulates MACC1-driven metastasis.
Siegel, F., Schmidt, H., Juneja, M., Smith, J., Herrmann, P., Kobelt, D., Sharma, K., Fichtner, I., Walther, W., Dittmar, G., Volkmer, R., Rathjen, F.G., Schlag, P.M. and Stein, U.
Frontiers in Oncology 13 : 1280977. 8 December 2023

A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
Singh, M., Kondrashkina, A., Widmann, T.J., Cortes, J.L., Bansal, V., Wang, J., Römer, C., Garcia-Canadas, M., Garcia-Perez, J.L., Hurst, L.D. and Izsvak, Z.
PLoS Biology 21 (6): e3002162. 20 June 2023

Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M., Kondraskhina, A.M., Hurst, L.D. and Izsvák, Z.
Journal of Clinical Investigation 133 (14): e172278. 17 July 2023

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Smith, E.J., Sathasivam, K., Landles, C., Osborne, G.F., Mason, M.A., Gomez-Paredes, C., Taxy, B.A., Milton, R.E., Ast, A., Schindler, F., Zhang, C., Duan, W., Wanker, E.E. and Bates, G.P.
Brain Communications 5 (1): fcad010. 20 January 2023

Urinary T cells identify renal antineutrophil cytoplasmic antibody-associated vasculitis and predict prognosis: a proof of concept study.
Sonnemann, J., Klocke, J., Bieringer, M., Rousselle, A., Eckardt, K.U., Elitok, S., Popovic, S., Bachmann, S., Kettritz, R., Salama, A.D., Enghard, P. and Schreiber, A.
Kidney International Reports 8 (4): 871-883. April 2023

Structure-based design of xanthine-imidazopyridines and -imidazothiazoles as highly potent and in vivo efficacious tryptophan hydroxylase inhibitors.
Specker, E., Wesolowski, R., Schütz, A., Matthes, S., Mallow, K., Wasinska-Kalwa, M., Winkler, L., Oder, A., Alenina, N., Pleimes, D., von Kries, J.P., Heinemann, U., Bader, M. and Nazaré, M.
Journal of Medicinal Chemistry 66 (21): 14866-14896. 9 November 2023

Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation.
Sporre, E., Karlsen, J., Schriever, K., Asplund-Samuelsson, J., Janasch, M., Strandberg, L., Karlsson, A., Kotol, D., Zeckey, L., Piazza, I., Syrén, P.O., Edfors, F. and Hudson, E.P.
Communications Biology 6 (1): 947. 18 September 2023

Doxorubicin changes the spatial organization of the genome around active promoters.
Stefanova, M.E., Ing-Simmons, E., Stefanov, S., Flyamer, I., Dorado Garcia, H., Schöpflin, R., Henssen, A.G., Vaquerizas, J.M. and Mundlos, S.
Cells 12 (15): 2001. 4 August 2023

Leveraging ligand affinity and properties: discovery of novel benzamide-type cereblon binders for the design of PROTACs.
Steinebach, C., Bricelj, A., Murgai, A., Sosič, I., Bischof, L., Ng, Y.L.D., Heim, C., Maiwald, S., Proj, M., Voget, R., Feller, F., Košmrlj, J., Sapozhnikova, V., Schmidt, A., Zuleeg, M.R., Lemnitzer, P., Mertins, P., Hansen, F.K., Gütschow, M., Krönke, J. and Hartmann, M.D.
Journal of Medicinal Chemistry 66 (21): 14513-14543. 9 November 2023

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
Subramaniam, G., Schleicher, K., Kovanich, D., Zerio, A., Folkmanaite, M., Chao, Y.C., Surdo, N.C., Koschinski, A., Hu, J., Scholten, A., Heck, A.J.R, Ercu, M., Sholokh, A., Chan Park, K., Klussmann, E., Meraviglia, V., Bellin, M., Zanivan, S., Hester, S., Mohammed, S. and Zaccolo, M.
Circulation Research 132 (7): 828-848. 31 March 2023

Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases.
Sun, C., Chen, J., Jin, M., Zhao, X., Li, Y., Dong, Y., Gao, N., Liu, Z., Bork, P., Zhao, X.M. and Chen, W.H.
Advanced Science 10 (25): 2302159. 5 September 2023

The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.
Szklarczyk, D., Kirsch, R., Koutrouli, M., Nastou, K., Mehryary, F., Hachilif, R., Gable, A.L., Fang, T., Doncheva, N.T., Pyysalo, S., Bork, P., Jensen, L.J. and von Mering, C.
Nucleic Acids Research 51 (D1): D638-D646. 6 January 2023

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Torcal Garcia, G., Kowenz-Leutz, E., Tian, T.V, Klonizakis, A., Lerner, J., De Andres-Aguayo, L., Sapozhnikova, V., Berenguer, C., Carmona, M.P., Casadesus, M.V., Bulteau, R., Francesconi, M., Peiro, S., Mertins, P., Zaret, K., Leutz, A. and Graf, T.
eLife 12 : e83951. 27 June 2023

CORUM: the comprehensive resource of mammalian protein complexes-2022.
Tsitsiridis, G., Steinkamp, R., Giurgiu, M., Brauner, B., Fobo, G., Frishman, G., Montrone, C. and Ruepp, A.
Nucleic Acids Research 51 (D1): D539-D545. 6 January 2023

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14 (1): 8043. 19 December 2023

Daratumumab as a novel treatment option in refractory ITP.
Vernava, I. and Schmitt, C.A.
Blood Cells Molecules and Diseases 99 : 102724. March 2023

Impact of first-line use of caplacizumab on treatment outcomes in immune thrombotic thrombocytopenic purpura.
Völker, L.A., Kaufeld, J., Balduin, G., Merkel, L., Kühne, L., Eichenauer, D.A., Osterholt, T., Hägele, H., Kann, M., Grundmann, F., Kolbrink, B., Schulte, K., Gäckler, A., Kribben, A., Boss, K., Potthoff, S.A., Rump, L.C., Schmidt, T., Mühlfeld, A.S., Schulmann, K., Hermann, M., Gaedeke, J., Sauerland, K., Bramstedt, J., Hinkel, U.P., Miesbach, W., Bauer, F., Westhoff, T.H., Bruck, H., Buxhofer-Ausch, V., Müller, T.J., Wendt, R., Harth, A., Schreiber, A., Seelow, E., Tölle, M., Gohlisch, C., Bieringer, M., Geuther, G., Jabs, W.J., Fischereder, M., von Bergwelt-Baildon, A., Schönermarck, U., Knoebl, P., Menne, J. and Brinkkoetter, P.T.
Journal of Thrombosis and Haemostasis 21 (3): 559-572. March 2023

Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Wallach, T., Raden, M., Hinkelmann, L., Brehm, M., Rabsch, D., Weidling, H., Krüger, C., Kettenmann, H., Backofen, R. and Lehnardt, S.
Frontiers in Immunology 13 : 1066456. 13 January 2023

Getting to the root of branched ubiquitin chains: a review of current methods and functions.
Waltho, A. and Sommer, T.
Methods in Molecular Biology 2602 : 19-38. 2023

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Wang, Z., Shaabani, S., Gao, X., Ng, Y.L.D., Sapozhnikova, V., Mertins, P., Krönke, J. and Dömling, A.
Nature Communications 14 (1): 8437. 19 December 2023

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.
Watkins, T.B.K., Colliver, E.C., Huska, M.R., Kaufmann, T.L., Lim, E.L., Duncan, C.B., Haase, K., Van Loo, P., Swanton, C., McGranahan, N. and Schwarz, R.F.
PLoS Computational Biology 19 (10): e1011379. 23 October 2023

PEDL+: Protein-centered relation extraction from PubMed at your fingertip.
Weber, L., Barth, F., Lorenz, L., Konrath, F., Huska, K., Wolf, J. and Leser, U.
Bioinformatics 39 (11): btad603. November 2023

ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution.
Wu, J.Z., Zeziulia, M., Kwon, W., Jentsch, T.J., Grinstein, S. and Freeman, S.A.
Journal of Cell Biology 222 (6): e202208155. 5 June 2023

Consistency across multi-omics layers in a drug-perturbed gut microbial community.
Wuyts, S., Alves, R., Zimmermann-Kogadeeva, M., Nishijima, S., Blasche, S., Driessen, M., Geyer, P.E, Hercog, R., Kartal, E., Maier, L., Müller, J.B., Garcia Santamarina, S., Schmidt, T.S.B., Sevin, D.C., Telzerow, A., Treit, P.V., Wenzel, T., Typas, A., Patil, K.R, Mann, M., Kuhn, M. and Bork, P.
Molecular Systems Biology 19 (9): e11525. 12 September 2023

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.
Xiong, E., Popp, O., Salomon, C., Mertins, P., Kocks, C., Rajewsky, K. and Chu, V.T.
Frontiers in Immunology 13 : 1083119. 5 January 2023

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.
Yan, S., Schöpe, P.C., Lewis, J., Putzker, K., Uhrig, U., Specker, E., von Kries, J.P., Lindemann, P., Omran, A., Sanchez-Ibarra, H.E., Unger, A., Zischinsky, M.L., Klebl, B., Walther, W., Nazaré, M., Kobelt, D. and Stein, U.
Biomedicine & Pharmacotherapy 168 : 115698. December 2023

What do you most hope spatial molecular profiling will help us understand? Part 2.
Yanai, I., Fertig, E.J., Li, M., Coscia, F., Klughammer, J., Nie, Q., Chen, J. and Coskun, A.F.
Cell Systems 14 (7): 543-546. 19 July 2023

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh, Y.T., Sona, C., Yan, X., Li, Y., Pathak, A., McDermott, M.I., Xie, Z., Liu, L., Arunagiri, A., Wang, Y., Cazenave-Gassiot, A., Ghosh, A., von Meyenn, F., Kumarasamy, S., Najjar, S.M., Jia, S., Wenk, M.R., Traynor-Kaplan, A., Arvan, P., Barg, S., Bankaitis, V.A. and Poy, M.N.
Nature Communications 14 (1): 4250. 17 July 2023

Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B., Zhang, S., Polovitskaya, M.M., Yi, J., Ye, B., Li, R., Huang, X., Yin, J., Neuens, S., Balfroid, T., Soblet, J., Vens, D., Aeby, A., Li, X., Cai, J., Song, Y., Li, Y., Tartaglia, M., Li, Y., Jentsch, T.J., Yang, M. and Liu, Z.
Science Advances 9 (41): eadg4479. 13 October 2023

Stable isotope-assisted untargeted metabolomics identifies ALDH1A1-driven erythronate accumulation in lung cancer cells.
Zhang, J., Keibler, M.A., Dong, W., Ghelfi, J., Cordes, T., Kanashova, T., Pailot, A., Linster, C.L., Dittmar, G., Metallo, C.M., Lautenschlaeger, T., Hiller, K. and Stephanopoulos, G.
Biomedicines 11 (10): 2842. 19 October 2023

2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.
Alborzinia, H., Flórez, A.F., Kreth, S., Brückner, L.M., Yildiz, U., Gartlgruber, M., Odoni, D.I., Poschet, G., Garbowicz, K., Shao, C., Klein, C., Meier, J., Zeisberger, P., Nadler-Holly, M., Ziehm, M., Paul, F., Burhenne, J., Bell, E., Shaikhkarami, M., Würth, R., Stainczyk, S.A., Wecht, E.M., Kreth, J., Büttner, M., Ishaque, N., Schlesner, M., Nicke, B., Stresemann, C., Llamazares-Prada, M., Reiling, J.H., Fischer, M., Amit, I., Selbach, M., Herrmann, C., Wölfl, S., Henrich, K.O., Höfer, T., Trumpp, A. and Westermann, F.
Nature Cancer 3 (4): 471-485. 28 April 2022

The monocyte, a maestro in the tumor microenvironment (TME) of breast cancer.
Amer, H.T., Stein, U. and El Tayebi, H.M.
Cancers 14 (21): 5460. 7 November 2022

Downregulation of odd-skipped related 2, a novel regulator of epithelial-mesenchymal transition, enables efficient somatic cell reprogramming.
Anh, L.P.H., Nishimura, K., Kuno, A., Nguyen, T.L., Kato, T., Ohtaka, M., Nakanishi, M., Sugihara, E., Sato, T.A., Hayashi, Y., Fukuda, A. and Hisatake, K.
Stem Cells 40 (4): 397-410. 29 April 2022

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton, S.E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M.J. and Bock, A.
Cell 185 (7): 1130-1142.e11. 31 March 2022

Immunohistochemical analysis of nicotinamide phosphoribosyltransferase expression in gastric and esophageal adenocarcinoma (AEG).
Arnold, A., von Winterfeld, M., Berg, E., Hummel, M., Rau, B., Krenzien, F., Stein, U. and Treese, C.
Gastrointestinal Disorders 4 (4): 333-340. 13 December 2022

Microglia form satellites with different neuronal subtypes in the adult murine central nervous system.
Bakina, O., Kettenmann, H. and Nolte, C.
Journal of Neuroscience Research 100 (4): 1105-1122. April 2022

Unraveling the hidden temporal range of fast β(2)-adrenergic receptor mobility by time-resolved fluorescence.
Balakrishnan, A., Hemmen, K., Choudhury, S., Krohn, J.H., Jansen, K., Friedrich, M., Beliu, G., Sauer, M., Lohse, M.J. and Heinze, K.G.
Communications Biology 5 (1): 176. 28 February 2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Balasubramanian, S., Andreani, M., Goncalves Andrade, J., Saha, T., Sundaravinayagam, D., Garzón, J., Zhang, W., Popp, O., Hiraga, S., Rahjouei, A., Rosen, D.B., Mertins, P., Chait, B.T., Donaldson, A.D. and Di Virgilio, M.
eLife 11 : e75047. 13 April 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S., Bulatov, T., Schmied, C., Krämer, A., Berger, B.T., Oder, A., Walker-Gray, R., Kuschke, C., Zühlke, K., Eichhorst, J., Lehmann, M., Knapp, S., Weston, J., von Kries, J.P., Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells.
Basti, A., Malhan, D., Dumbani, M., Dahlmann, M., Stein, U. and Relógio, A.
Cancers 14 (14): 3458. 16 July 2022

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics.
Baytek, G., Blume, A., Demirel, F.G., Bulut, S., Popp, O., Mertins, P. and Tursun, B.
Biotechniques 73 (1): 5-17. June 2022

Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation.
Baytek, G., Popp, O., Mertins, P. and Tursun, B.
Biotechniques 72 (5): 175-184. May 2022

Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified clostridium perfringens enterotoxin (CPE).
Beier, L.S., Piontek, J., Piontek, A., Protze, J., Kobelt, D. and Walther, W.
Methods in Molecular Biology 2521 (3): 173-188. 23 June 2022

In memoriam: Stephen B. McMahon, PhD, FMedSci December 21, 1954 to October 9, 2021.
Bennett, D.L.H., Bradbury, E.J., Lewin, G.R. and Rice, A.S.C.
Pain 163 (3): 403-405. March 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M., Tucker, E., Dorel, M., Winkler, A., McGearey, A., Rodriguez-Fos, E., da Costa, B.M., Barker, K., Fyle, E., Calton, E., Eising, S., Ober, K., Hughes, D., Koutroumanidou, E., Carter, P., Stankunaite, R., Proszek, P., Jain, N., Rosswog, C., Dorado-Garcia, H., Molenaar, J.J., Hubank, M., Barone, G., Anderson, J., Lang, P., Deubzer, H.E., Künkele, A., Fischer, M., Eggert, A., Kloft, C., Henssen, A.G., Boettcher, M., Hertwig, F., Blüthgen, N., Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

The impact of membrane protein diffusion on GPCR signaling.
Boltz, H.H., Sirbu, A., Stelzer, N., de Lanerolle, P., Winkelmann, S. and Annibale, P.
Cells 11 (10): 1660. 17 May 2022

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradation.
Brischetto, C., Mucka, P., Kaergel, E. and Scheidereit, C.
bioRxiv : 2022.11.02.514846. 2 November 2022

Taking out the trash: How misfolded proteins are removed from the endoplasmic reticulum.
Brodsky, J.L., Engelman, D.M., Hendershot, L.M., Piana-Agostinetti, S. and Sommer, T.
Faculty Reviews 11 : 29. 5 October 2022

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brieño-Enríquez, M.A., Bronner, G.N., Coen, C., Delaney, M.A., Dengler-Crish, C.M., Edrey, Y.H., Faulkes, C.G., Frankel, D., Friedlander, G., Gibney, P.A., Gorbunova, V., Hine, C., Holmes, M.M., Jarvis, J.U.M., Kawamura, Y., Kutsukake, N., Kenyon, C., Khaled, W.T., Kikusui, T., Kissil, J., Lagestee, S., Larson, J., Lauer, A., Lavrenchenko, L.A., Lee, A., Levitt, J.B., Lewin, G.R., Lewis Hardell, K.N., Lin, T.D., Mason, M.J., McCloskey, D., McMahon, M., Miura, K., Mogi, K., Narayan, V., O'Connor, T.P., Okanoya, K., O'Riain, M.J., Park, T.J., Place, N.J., Podshivalova, K., Pamenter, M.E., Pyott, S.J., Reznick, J., Ruby, J.G., Salmon, A.B., Santos-Sacchi, J., Sarko, D.K., Seluanov, A., Shepard, A., Smith, M., Storey, K.B., Tian, X., Vice, E.N., Viltard, M., Watarai, Ak., Wywial, E., Yamakawa, M., Zemlemerova, E.D., Zions, M. and Smith, E.S.J.
Biological Reviews 97 (1): 115-140. February 2022

Obesity, colorectal cancer and MACC1 expression: a possible novel molecular association.
Bähr, I., Jaeschke, L., Nimptsch, K., Janke, J., Herrmann, P., Kobelt, D., Kielstein, H., Pischon, T. and Stein, U.
International Journal of Oncology 60 (2): 17. February 2022

Immune competence and spleen size scale with colony status in the naked mole-rat.
Bégay, V., Cirovic, B., Barker, A.J., Klopffleisch, R., Hart, D.W., Bennett, N.C. and Lewin, G.R.
Open Biology 12 (4): 210292. 6 April 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R., Aronsen, J.M., Bergan-Dahl, A., Moutty, M.C., Lunde, M., Lunde, P.K., Jarstadmarken, H., Wanichawan, P., Pereira, L., Kolstad, T.R.S., Dalhus, B., Subramanian, H., Hille, S., Christensen, G., Müller, O.J., Nikolaev, V., Bers, D.M., Sjaastad, I., Shen, X., Louch, W.E., Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

Towards the biogeography of prokaryotic genes.
Coelho, L.P., Alves, R., Del Río, Á.R., Myers, P.N., Cantalapiedra, C.P., Giner-Lamia, J., Schmidt, T.S., Mende, D.R., Orakov, A., Letunic, I., Hildebrand, F., Van Rossum, T., Forslund, S.K., Khedkar, S., Maistrenko, O.M., Pan, S., Jia, L., Ferretti, P., Sunagawa, S., Zhao, X.M., Nielsen, H.B., Huerta-Cepas, J. and Bork, P.
Nature 601 (7892): 252-256. 13 January 2022

Combination of Wnt/β-catenin targets S100A4 and DKK1 improves prognosis of human colorectal cancer.
Dahlmann, M., Monks, A., Harris, E.D., Kobelt, D., Osterland, M., Khaireddine, F., Herrmann, P., Kemmner, W., Burock, S., Walther, W., Shoemaker, R.H. and Stein, U.
Cancers 14 (1): 37. 2022

Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases.
Damerau, A., Kirchner, M., Pfeiffenberger, M., Ehlers, L., Do Nguyen, D.H., Mertins, P., Bartek, B., Maleitzke, T., Palmowski, Y., Hardt, S., Winkler, T., Buttgereit, F. and Gaber, T.
Metabolic Engineering 72 : 116-132. July 2022

SPFH protein cage - one ring to rule them all.
Daumke, O. and Lewin, G.R.
Cell Research 32 (2): 117-118. February 2022

Functional repertoire convergence of distantly related eukaryotic plankton lineages abundant in the sunlit ocean.
Delmont, T.O., Gaia, M., Hinsinger, D.D., Frémont, P., Vanni, C., Fernandez-Guerra, A., Eren, A.M., Kourlaiev, A., d'Agata, L., Clayssen, Q., Villar, E., Labadie, K., Cruaud, C., Poulain, J., Da Silva, C., Wessner, M., Noel, B., Aury, J.M., de Vargas, C., Bowler, C., Karsenti, E., Pelletier, E., Wincker, P. and Jaillon, O.
Cell Genomics 2 (5): 100123. 11 May 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Simultaneous imaging and flow-cytometry-based detection of multiple fluorescent senescence markers in therapy-induced senescent cancer cells.
Dovjak, E., Mairhofer, M., Wöß, C., Qi, J., Fan, D.N.Y., Schmitt, C.A. and Yu, Y.
Journal of Visualized Experiments (185): e63973. 12 July 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132 (23): e160089. 1 December 2022

Gender differences in perceptions and attitudes of medical students towards neurosurgery: a german nationwide survey.
Efe, I.E., Aliyeva, I., Beyaztas, D., Swiatek, V.M., Esene, I.N. and Abdulrauf, S.I.
World Neurosurgery 163 : 96-103. July 2022

The anti-glucocorticoid receptor antibody clone 5E4: raising awareness of unspecific antibody binding.
Ehlers, L., Kirchner, M., Mertins, P., Strehl, C., Buttgereit, F. and Gaber, T.
International Journal of Molecular Sciences 23 (9): 5049. 2 May 2022

An integrated pharmacological, structural, and genetic analysis of extracellular versus intracellular ROS production in neutrophils.
Ellson, C.D., Goretti Riça, I., Kim, J.S., Huang, Y.M.M., Lim, D., Mitra, T., Hsu, A., Wei, E.X., Barrett, C.D., Otterbein, L.E., Hauser, C.J., Wahl, M., Delbrück, H., Heinemann, U., Oschkinat, H., Chang, C.E.A. and Yaffe, M.B.
Journal of Molecular Biology 434 (9): 167533. 15 May 2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Evidence for recombinant GRP78, CALR, PDIA3 and GPI as mediators of genetic instability in human CD34+ cells.
Fabarius, A., Samra, V., Drews, O., Mörz, H., Bierbaum, M., Darwich, A., Weiss, C., Brendel, S., Kleiner, H., Seifarth, W., Greffrath, W., Hofmann, W.K., Schmitt, C.A. and Popp, H.D.
Cancers 14 (12): 2883. 11 June 2022

A cFLIP-flop switch for senolysis.
Fan, D.N.Y. and Schmitt, C.A.
Nature Cancer 3 (11): 1279-1281. November 2022

One gene - two proteins: the C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria.
Fasciani, I., Petragnano, F., Wang, Z., Edwards, R., Telugu, N., Pietrantoni, I., Zauber, H., Rossi, M., Zabel, U., Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Poehl, B., Aringhieri, S., Aloisi, G., Marampon, F., Roman, A., Diecke, S., Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Lohse, M.J., Maggio, R. and Annibale, P.
bioRxiv : 2021.04.13.438299. 26 February 2022

Editorial: The long road to building a head: smooth travels and accidents on the journey from patterning via morphogenesis to phenotype.
Feistel, K., Hammes, A. and Sela-Donenfeld, D.
Frontiers in Cell and Developmental Biology 10 : 895497. 25 April 2022

C. difficile is overdiagnosed in adults and a commensal in infants.
Ferretti, P., Wirbel, J., Maistrenko, O.M., Van Rossum, T., Alves, R., Fullam, A., Akanni, W., Schudoma, C., Schwarz, A., Thielemann, R., Thomas, L., Kuhn, M., Zeller, G., Schmidt, T.S.B. and Bork, P.
bioRxiv : 2022.02.16.480740v1. 18 February 2022

The SCF/KIT axis in human mast cells: capicua acts as potent KIT repressor and ERK predominates PI3K.
Franke, K., Kirchner, M., Mertins, P., Zuberbier, T. and Babina, M.
Allergy 77 (11): 3337-3349. November 2022

Dataset debt in biomedical language modeling.
Fries, J.A., Seelam, N., Altay, G., Weber, L., Kang, M., Datta, D., Su, R., Garda, S., Wang, B., Ott, S., Samwald, M. and Kusa, W.
In: 2022 Challenges and Perspectives in Creating Large Language Models, 27 May 2022, Virtual, Dublin. May 2022

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts.
Gabelich, J.A., Grützke, J., Kirscht, F., Popp, O., Matz, J.M., Dittmar, G., Rug, M. and Ingmundson, A.
PLoS Pathogens 18 (9): e1010846. 20 September 2022

Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression?
Geladaris, A., Torke, S. and Weber, M.S.
CNS drugs 36 (10): 1019-1030. October 2022

The role of intraspinal sensory neurons in the control of quadrupedal locomotion.
Gerstmann, K., Jurčić, N., Blasco, E., Kunz, S., de Almeida Sassi, F., Wanaverbecq, N. and Zampieri, N.
Current Biology 32 (11): 2442-2453. 6 June 2022

An unusual aspartic acid cluster in the reovirus attachment fiber s1 mediates stability at low pH and preserves trimeric organization.
Glorani, G., Ruwolt, M., Holton, N., Loll, B. and Neu, U.
Journal of Virology 96 (8): e0033122. April 2022

Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes.
Gmach, P., Bathe-Peters, M., Telugu, N., Miller, D.C. and Annibale, P.
International Journal of Molecular Sciences 23 (18): 10405. 8 September 2022

Real-world evidence for preventive effects of statins on cancer incidence: a trans-atlantic analysis.
Gohlke, B.O., Zincke, F., Eckert, A., Kobelt, D., Preissner, S., Liebeskind, J.M., Gunkel, N., Putzker, K., Lewis, J., Preissner, S., Kortüm, B., Walther, W., Mura, K., Bourne, P.E., Stein, U. and Preissner, R.
Clinical and Translational Medicine 12 (2): e726. 20 February 2022

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.
Greco, T.M., Secker, C., Silva Ramos, E., Federspiel, J.D., Liu, J.P., Perez, A.M., Al-Ramahi, I., Cantle, J.P., Carroll, J.B., Botas, J., Zeitlin, S.O., Wanker, E.E. and Cristea, I.M.
Cell Systems 13 (4): 304-320.e5. 22 April 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J., Kosel, F., Goveas, N., Kranz, A., Alexopoulou, D., Rajewsky, K., Sigal, M., Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients.
Grunow, J.J., Reiher, K., Carbon, N.M., Engelhardt, L.J., Mai, K., Koch, S., Schefold, J.C., Z'Graggen, W., Schaller, S.J., Fielitz, J., Spranger, J., Weber-Carstens, S. and Wollersheim, T.
Critical Care 26 (1): 237. 3 August 2022

MACC1-dependent antitumor effect of curcumin in colorectal cancer.
Güllü, N., Smith, J., Herrmann, P. and Stein, U.
Nutrients 14 (22): 4792. 12 November 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G., Conlon, T.M., Jeridi, A., Kim, R., Ertüz, Z., Lang, N.J., Ansari, M., Novikova, M., Jiang, D., Strunz, M., Gaianova, M., Hollauer, C., Gabriel, C., Angelidis, I., Doll, S., Pestoni, J.C., Edelmann, S.L., Kohlhepp, M.S., Guillot, A., Bassler, K., Van Eeckhoutte, H.P., Kayalar, Ö., Konyalilar, N., Kanashova, T., Rodius, S., Ballester-López, C., Genes Robles, C.M., Smirnova, N., Rehberg, M., Agarwal, C., Krikki, I., Piavaux, B., Verleden, S.E., Vanaudenaerde, B., Königshoff, M., Dittmar, G., Bracke, K.R., Schultze, J.L., Watz, H., Eickelberg, O., Stoeger, T., Burgstaller, G., Tacke, F., Heissmeyer, V., Rinkevich, Y., Bayram, H., Schiller, H.B., Conrad, M., Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

A molecularly characterized preclinical platform of subcutaneous renal cell carcinoma (RCC) patient-derived xenograft models to evaluate novel treatment strategies.
Gürgen, D., Becker, M., Dahlmann, M., Flechsig, S., Schaeffeler, E., Büttner, F.A., Schmees, C., Bohnert, R., Bedke, J., Schwab, M., Wendler, J.J., Schostak, M., Jandrig, B., Walther, W. and Hoffmann, J.
Frontiers in Oncology 12 : 889789. 21 June 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G.
Cancer Discovery 12 (2): 293-295. 9 February 2022

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E., Lisek, K., Vogel, R., Wulf-Goldenberg, A., Alcaniz, J., Montaudon, E., Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24 (1): 23. 1 April 2022

A novel AQP2 sequence variant causing aquaporin-2 retention in the cytoplasm and autosomal dominant nephrogenic diabetes insipidus.
Hinrichs, G.R., Baltzer, S., Pallien, T., Svenningsen, P., Dalgaard, E.B., Hertz, J.M., Bistrup, C., Jensen, B.L. and Klussmann, E.
Kidney International Reports 7 (10): 2289-2294. October 2022

Uncoupling the excitatory amino acid transporter 2 from its C-terminal interactome restores synaptic glutamate clearance at corticostriatal synapses and alleviates mutant huntingtin-induced hypokinesia.
Hirschberg, S., Dvorzhak, A., Rasooli-Nejad, S.M.A., Angelov, S., Kirchner, M., Mertins, P., Lättig-Tünnemann, G., Harms, C., Schmitz, D. and Grantyn, R.
Frontiers in Cellular Neuroscience 15 : 792652. 31 January 2022

Mechanisms of spermidine-induced autophagy and geroprotection.
Hofer, S.J., Simon, A.K., Bergmann, M., Eisenberg, T., Kroemer, G. and Madeo, F.
Nature Aging 2 (12): 1112-1129. December 2022

MACC1-induced collective migration is promoted by proliferation rather than single cell biomechanics.
Hohmann, T., Hohmann, U., Dahlmann, M., Kobelt, D., Stein, U. and Dehghani, F.
Cancers 14 (12): 2857. 9 June 2022

Microglia/macrophage derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model.
Huang, Y., Motta, E., Nanvuma, C., Kuhrt, L.D., Yuan, Y., Xia, P., Lubas, M., Zhu, S., Schnauss, M., Qazi, N., Hu, F., Zhang, H., Lei, T., Synowitz, M., Flüh, C. and Kettenmann, H.
Cell Reports 39 (2): 110670. 12 April 2022

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L., Luebeck, J., Dehkordi, S.R., Colón, C.I., Li, R., Wong, I.T.L., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E., Moriceau, G., Zhang, X., Bailey, C., Houlahan, K.E., Yang, W., González, R.C., Swanton, C., Curtis, C., Jamal-Hanjani, M., Henssen, A.G., Law, J.A., Greenleaf, W.J., Lo, R.S., Mischel, P.S., Bafna, V. and Chang, H.Y.
Nature Genetics 54 (11): 1746–1754. November 2022

Physical performance and non-esterified fatty acids in men and women after transcatheter aortic valve implantation (TAVI).
Härdrich, M., Haase-Fielitz, A., Fielitz, J., Boschmann, M., Pivovarova-Ramich, O., Pfeiffer, A.F.H., Rudovich, N., Weylandt, K.H. and Butter, C.
Nutrients 14 (1): 203. 2 January 2022

Evaluation of pharmacological rescue of melanocortin-4 receptor nonsense mutations by aminoglycoside.
Höpfner, F., Paisdzior, S., Reininghaus, N., Sohail, I., Scheerer, P., Annibale, P., Biebermann, H. and Kühnen, P.
Life 12 (11): 1793. 5 November 2022

H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10 (10): e005535. 27 October 2022

Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A., Mattei, D., Radscheit, K., Compagnion, A.C., Pett, J.P., Herzel, H.P., Paolicelli, R.C., Piwecka, M., Meyer, U. and Beule, D.
International Journal of Molecular Sciences 23 (20): 12347. October 2022

Targeting cathepsin C in PR3-ANCA vasculitis.
Jerke, U., Eulenberg-Gustavus, C., Rousselle, A., Nicklin, P., Kreideweiss, S., Grundl, M.A., Eickholz, P., Nickles, K., Schreiber, A., Korkmaz, B. and Kettritz, R.
Journal of the American Society of Nephrology 33 (5): 936-947. May 2022

DNA methylation-based classification of sinonasal tumors.
Jurmeister, P., Glöß, S., Roller, R., Leitheiser, M., Schmid, S., Mochmann, L.H., Payá Capilla, E., Fritz, R., Dittmayer, C., Friedrich, C., Thieme, A., Keyl, P., Jarosch, A., Schallenberg, S., Bläker, H., Hoffmann, I., Vollbrecht, C., Lehmann, A., Hummel, M., Heim, D., Haji, M., Harter, P., Englert, B., Frank, S., Hench, J., Paulus, W., Hasselblatt, M., Hartmann, W., Dohmen, H., Keber, U., Jank, P., Denkert, C., Stadelmann, C., Bremmer, F., Richter, A., Wefers, A., Ribbat-Idel, J., Perner, S., Idel, C., Chiariotti, L., Della Monica, R., Marinelli, A., Schüller, U., Bockmayr, M., Liu, J., Lund, V.J., Forster, M., Lechner, M., Lorenzo-Guerra, S.L., Hermsen, M., Johann, P.D., Agaimy, A., Seegerer, P., Koch, A., Heppner, F., Pfister, S.M., Jones, D.T.W., Sill, M., von Deimling, A., Snuderl, M., Müller, K.R., Forgó, E., Howitt, B.E., Mertins, P., Klauschen, F. and Capper, D.
Nature Communications 13 (1): 7148. 28 November 2022

Small molecule inhibitors for hepatocellular carcinoma: advances and challenges.
Kamal, M.A., Mandour, Y.M., Abd El-Aziz, M.K., Stein, U. and El Tayebi, H.M.
Molecules 27 (17): 5537. 1 September 2022

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal, E., Schmidt, T.S.B., Molina-Montes, E., Rodríguez-Perales, S., Wirbel, J., Maistrenko, O.M., Akanni, W.A., Alashkar Alhamwe, B., Alves, R.J., Carrato, A., Erasmus, H.P., Estudillo, L., Finkelmeier, F., Fullam, A., Glazek, A.M., Gómez-Rubio, P., Hercog, R., Jung, F., Kandels, S., Kersting, S., Langheinrich, M., Márquez, M., Molero, X., Orakov, A., Van Rossum, T., Torres-Ruiz, R., Telzerow, A., Zych, K., Benes, V., Zeller, G., Trebicka, J., Real, F.X., Malats, N. and Bork, P.
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Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M., Schaupp, A.L., Sun, R., Coscia, F., Dendrou, C.A., Cortes, A., Kaur, G., Evans, H.G., Mollbrink, A., Navarro, J.F., Sonner, J.K., Mayer, C., DeLuca, G.C., Lundeberg, J., Matthews, P.M., Attfield, K.E., Friese, M.A., Mann, M. and Fugger, L.
Nature Neuroscience 25 (7): 944-955. July 2022

Real-time measurements of intracellular cAMP gradients using FRET-based cAMP nanorulers.
Kayser, C., Lohse, M.J. and Bock, A.
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Glial cells: neuroglia.
Kettenmann, H. and Verkhratsky, A.
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Complement is complimentary in membranous nephropathy.
Kettritz, R. and Schreiber, A.
Journal of the American Society of Nephrology 33 (9): 1631-1633. September 2022

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.
Khedkar, S., Smyshlyaev, G., Letunic, I., Maistrenko, O.M., Coelho, L.P., Orakov, A., Forslund, S.K., Hildebrand, F., Luetge, M., Schmidt, T.S.B., Barabas, O. and Bork, P.
Nucleic Acids Research 50 (6): 3155-3168. 8 April 2022

Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone 1 receptor.
Klenk, C., Hommers, L. and Lohse, M.J.
Frontiers in Endocrinology 13 : 839351. 22 February 2022

Meconium microbiome of very preterm infants across Germany.
Klopp, J., Ferretti, P., Meyer, C.U., Hilbert, K., Haiß, A., Marißen, J., Henneke, P., Hudalla, H., Pirr, S., Viemann, D., Zemlin, M., Forslund, S.K., Härtel, C., Bork, P., Gehring, S. and Van Rossum, T.
mSphere 7 (1): e0080821. 23 February 2022

Hidden agenda - the involvement of endoplasmic reticulum stress and unfolded protein response in inflammation-induced muscle wasting.
Kny, M. and Fielitz, J.
Frontiers in Immunology 13 : 878755. 9 May 2022

A brief introduction to current cancer gene therapy.
Kobelt, D., Pahle, J. and Walther, W.
Methods in Molecular Biology 2521 (3): 1-21. 23 June 2022

Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade.
Kofla, G., Radecke, C., Frentsch, M., Walther, W., Stintzing, S., Riess, H., Bullinger, L. and Na, I.K.
OncoImmunology 11 (1): 2068109. 25 April 2022

Functional indications for transposase domestications - characterization of the human piggyBac transposase derived (PGBD) activities.
Kolacsek, O., Wachtl, G., Fóthi, Á., Schamberger, A., Sándor, S., Pergel, E., Varga, N., Raskó, T., Izsvák, Z., Apáti, Á. and Orbán, T.I.
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Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis.
Kortüm, B., Radhakrishnan, H., Zincke, F., Sachse, C., Burock, S., Keilholz, U., Dahlmann, M., Walther, W., Dittmar, G., Kobelt, D. and Stein, U.
Oncogene 41 (39): 4446-4458. 23 September 2022

GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of age-related macular degeneration.
Kropp, M., Harmening, N., Bascuas, T., Johnen, S., De Clerck, E., Fernández, V., Ronchetti, M., Cadossi, R., Zanini, C., Scherman, D., Ivics, Z., Marie, C., Izsvák, Z. and Thumann, G.
Biomedicines 10 (11): 2777. November 2022

Paracrine interleukin 6 induces cerebral remodeling at early stages after unilateral common carotid artery occlusion in mice.
Kuffner, M.T.C., Koch, S.P, Kirchner, M., Mueller, S., Lips, J., An, J., Mertins, P., Dirnagl, U., Endres, M., Boehm-Sturm, P., Harms, C. and Hoffmann, C.J.
Frontiers in Cardiovascular Medicine 8 : 805095. 27 January 2022

Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by integrated multi-omic analyses.
Kunath, B.J., Hickl, O., Queirós, P., Martin-Gallausiaux, C., Lebrun, L.A., Halder, R., Laczny, C.C., Schmidt, T.S.B., Hayward, M.R., Becher, D., Heintz-Buschart, A., de Beaufort, C., Bork, P., May, P. and Wilmes, P.
Microbiome 10 (1): 243. 28 December 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T., Rose, J.C., Chen, C.Y., Pichugin, Y., Xie, L., Tang, J., Hung, K.L., Yost, K.E., Shi, Q., Erb, M.L., Rajkumar, U., Wu, S., Taschner-Mandl, S., Bernkopf, M., Swanton, C., Liu, Z., Huang, W., Chang, H.Y., Bafna, V., Henssen, A.G., Werner, B. and Mischel, P.S.
Nature Genetics 54 (10): 1527-1533. October 2022

A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments.
Langenhan, J., Jaeger, C., Baum, K., Simon, M. and Lisec, J.
Metabolites 12 (5): 408. 29 April 2022

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors.
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Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo, W.T., Zhang, Y., Vadas, O., Roske, Y., Gulluni, F., De Santis, M.C., Zagar, A.V., Stephanowitz, H., Hirsch, E., Liu, F., Daumke, O., Kudryashev, M. and Haucke, V.
Nature Structural & Molecular Biology 29 (3): 218-228. March 2022

Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6.
Lorenz, C., Zink, A., Henke, M.T., Staege, S., Mlody, B., Bünning, M., Wanker, E., Diecke, S., Schuelke, M. and Prigione, A.
Stem Cell Research 61 : 102742. May 2022

Tongue immune compartment analysis reveals spatial macrophage heterogeneity.
Lyras, E.M., Zimmermann, K., Wagner, L.K., Dörr, D., Klose, C.S.N, Fischer, C., Jung, S., Yona, S., Hovav, A.H., Stenzel, W., Dommerich, S., Conrad, T., Leutz, A. and Mildner, A.
eLife 11 : 77490. 24 June 2022

Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 33 (8): 1528-1545. August 2022

Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
Mackert, O., Wirth, E.K., Sun, R., Winkler, J., Liu, A., Renko, K., Kunz, S., Spranger, J. and Brachs, S.
Molecular Metabolism 64 : 101563. October 2022

Forebrain development - an intricate balance decides between health and disease.
Mamo, T.M. and Hammes, A.
Neuroforum 28 (4): 233-243. 25 November 2022

In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasets.
Mari, T., Mösbauer, K., Wyler, E., Landthaler, M., Drosten, C. and Selbach, M.
Journal of Proteome Research 21 (6): 1575-1587. 3 June 2022

Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
Marino, S.F., Jerke, U., Rolle, S., Daumke, O. and Kettritz, R.
Journal of Biological Chemistry 298 (3): 101598. March 2022

Molecular and functional characterization of BDNF-overexpressing human retinal pigment epithelial cells established by sleeping beauty transposon-mediated gene transfer.
Mattern, L., Otten, K., Miskey, C., Fuest, M., Izsvák, Z., Ivics, Z., Walter, P., Thumann, G. and Johnen, S.
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Physiological functions of intracellular protein degradation.
McShane, E. and Selbach, M.
Annual Review of Cell and Developmental Biology 38 : 241-262. October 2022

Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets.
Melder, F.T., Lindemann, P., Welle, A., Trouillet, V., Heißler, S., Nazaré, M. and Selbach, M.
ChemMedChem 17 (19): e202200346. 6 October 2022

Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A., Sprink, T., Noel, J.K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C.M.T. and Daumke, O.
Nature Communications 13 (1): 7641. 10 December 2022

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C., Lisowski, P., Lickfett, S., Mlody, B., Bünning, M., Genehr, C., Ulrich, C., Wanker, E.E., Diecke, S., Priller, J. and Prigione, A.
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Suicide nanoplasmids coding for ribosome-inactivating proteins.
Mitdank, H., Tröger, M., Sonntag, A., Shirazi, N.A., Woith, E., Fuchs, H., Kobelt, D., Walther, W. and Weng, A.
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Immune cell C/EBPβ deficiency is associated with hepatic mononuclear defects and spontaneous hepatitis but not steatohepatitis induced liver fibrosis.
Moshkovits, I., Kaminitz, A., Reuveni, D., Pasmanik-Chor, M., Brazowski, E., Mildner, A., Leutz, A. and Zigmond, E.
Immunity, inflammation and disease 10 (11): e728. November 2022

Deep Visual Proteomics defines single-cell identity and heterogeneity.
Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A.D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L.M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M.A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. and Mann, M.
Nature Biotechnology 40 (8): 1231-1240. August 2022

The molecular mechanism and physiological role of silent nociceptor activation.
Nees, T.A., Wang, N., Adamek, P., Verkest, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Zeitzschel, N., Begay, V., Lee, Y.J., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
bioRxiv : 2022.04.07.486730. 19 October 2022

Functional modulation of PTH1R activation and signaling by RAMP2.
Nemec, K., Schihada, H., Kleinau, G., Zabel, U., Grushevsky, E.O., Scheerer, P., Lohse, M.J. and Maiellaro, I.
Proceedings of the National Academy of Sciences of the United States of America 119 (32): e2122037119. 9 August 2022

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
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Nature Communications 13 (1): 1009. 23 February 2022

Gene gun Her2/neu DNA vaccination: evaluation of vaccine efficacy in a syngeneic Her2/neu mouse tumor model.
Nguyen-Hoai, T., Hohn, O., Pezzutto, A. and Westermann, J.
Methods in Molecular Biology 2521 (3): 129-154. 23 June 2022

Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: differential toxicological impacts of biogenic and anthropogenic secondary organic aerosols (SOAs).
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Environmental Health Perspectives 130 (2): 27003. 3 February 2022

Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
Ojeda-Alonso, J., Bégay, V., Garcia-Contreras, J.A., Campos-Pérez, A.F., Purfürst, B. and Lewin, G.R.
Journal of General Physiology 154 (12): e202213098. 5 December 2022

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13 (1): 6407. 27 October 2022

Biosynthetic potential of the global ocean microbiome.
Paoli, L., Ruscheweyh, H.J., Forneris, C.C., Hubrich, F., Kautsar, S., Bhushan, A., Lotti, A., Clayssen, Q., Salazar, G., Milanese, A., Carlström, C.I., Papadopoulou, C., Gehrig, D., Karasikov, M., Mustafa, H., Larralde, M., Carroll, L.M., Sánchez, P., Zayed, A.A., Cronin, D.R., Acinas, S.G., Bork, P., Bowler, C., Delmont, T.O., Gasol, J.M., Gossert, A.D., Kahles, A., Sullivan, M.B., Wincker, P., Zeller, G., Robinson, S.L., Piel, J. and Sunagawa, S.
Nature 607 (7917): 111-118. 7 July 2022

Microglia states and nomenclature: A field at its crossroads.
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Neuron 110 (21): 3458-3483. 2 November 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
Pardo, M., Offer, S., Hartner, E., Di Bucchianico, S., Bisig, C., Bauer, S., Pantzke, J., Zimmermann, E.J., Cao, X., Binder, S., Kuhn, E., Huber, A., Jeong, S., Käfer, U., Schneider, E., Mesceriakovas, A., Bendl, J., Brejcha, R., Buchholz, A., Gat, D., Hohaus, T., Rastak, N., Karg, E., Jakobi, G., Kalberer, M., Kanashova, T., Hu, Y., Ogris, C., Marsico, A., Theis, F., Shalit, T., Gröger, T., Rüger, C.P., Oeder, S., Orasche, J., Paul, A., Ziehm, T., Zhang, Z.H., Adam, T., Sippula, O., Sklorz, M., Schnelle-Kreis, J., Czech, H., Kiendler-Scharr, A., Zimmermann, R. and Rudich, Y.
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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
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Nature Communications 13 (1): 1018. 23 February 2022

Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior.
Pohl, T. and Hörnberg, H.
Neuronal Signaling 6 (2): NS20210030. June 2022

Enrichment of gut microbiome strains for cultivation-free genome sequencing using droplet microfluidics.
Pryszlak, A., Wenzel, T., Seitz, K.W., Hildebrand, F., Kartal, E., Cosenza, M.R., Benes, V., Bork, P. and Merten, C.A.
Cell Reports Methods 2 (1): 100137. 24 January 2022

Targeting Wnt/β-catenin signaling by TET1/FOXO4 inhibits metastatic spreading and self-renewal of cancer stem cells in gastric cancer.
Qi, J., Cui, D., Wu, Q.N., Zhao, Q., Chen, Z.H., Li, L., Birchmeier, W., Yu, Y. and Tao, R.
Cancers 14 (13): 3232. 30 June 2022

A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39 (10): msac175. October 2022

Development of an indole-amide-based photoswitchable cannabinoid receptor subtype 1 (CB(1)R) "Cis-On" agonist.
Rodríguez-Soacha, D.A., Steinmüller, S.A.M., Işbilir, A., Fender, J., Deventer, M.H., Ramírez, Y.A., Tutov, A., Sotriffer, C., Stove, C.P., Lorenz, K., Lohse, M.J., Hislop, J.N. and Decker, M.
ACS Chemical Neuroscience 13 (16): 2410-2435. 17 August 2022

CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A., Sonnemann, J., Amann, K., Mildner, A., Lodka, D., Kling, L., Bieringer, M., Schneider, U., Leutz, A., Enghard, P., Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments.
Ruscheweyh, H.J., Milanese, A., Paoli, L., Karcher, N., Clayssen, Q., Keller, M.I., Wirbel, J., Bork, P., Mende, D.R., Zeller, G. and Sunagawa, S.
Microbiome 10 (1): 212. 5 December 2022

Enriched environment attenuates enhanced trait anxiety in association with normalization of aberrant neuro-inflammatory events.
Sah, A., Rooney, S., Kharitonova, M., Sartori, S.B., Wolf, S.A. and Singewald, N.
International Journal of Molecular Sciences 23 (21): 13052. 27 October 2022

High-fat-diet-evoked disruption of the rat dorsomedial hypothalamic clock can be prevented by restricted nighttime feeding.
Sanetra, A.M., Acevedo-Ochoa, E., Chrobok, L., Jeczmien-Lazur, J.S., Gawron, E., Klich, J.D., Pradel, K. and Lewandowski, M.H.
Nutrients 14 (23): 5034. 26 November 2022

Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M., Chao, C.C., Wang, Y.C., Kenison, J.E., Li, Z., Rone, J.M., Rejano-Gordillo, C.M., Polonio, C.M., Gutierrez-Vazquez, C., Piester, G., Plasencia, A., Li, L., Giovannoni, F., Lee, H.G., Faust Akl, C., Wheeler, M.A., Mascanfroni, I., Jaronen, M., Alsuwailm, M., Hewson, P., Yeste, A., Andersen, B.M., Franks, D.G., Huang, C.J., Ekwudo, M., Tjon, E.C., Rothhammer, V., Takenaka, M., de Lima, K.A., Linnerbauer, M., Guo, L., Covacu, R., Queva, H., Fonseca-Castro, P.H., Bladi, M.A., Cox, L.M., Hodgetts, K.J., Hahn, M.E., Mildner, A., Korzenik, J., Hauser, R., Snapper, S.B. and Quintana, F.J.
Nature 611 (7937): 801-809. 24 November 2022

Serum dihydrotestosterone is associated with adverse myocardial remodeling in patients with aortic valve stenosis before and after aortic valve replacement.
Schafstedde, M., Nordmeyer, J., Berger, F., Knosalla, C., Mertins, P., Regitz-Zagrosek, V., Kuehne, T., Kraus, M. and Nordmeyer, S.
American Journal of Physiology Heart and Circulatory Physiology 323 (5): H949-H957. November 2022

Capillary gel electrophoresis (CGE) for quality control of plasmid DNA in gene therapy: quality control of 20 years stored GMP-grade plasmid DNA.
Schmeer, M., Schleef, M., Shankar, R., Kobelt, D. and Walther, W.
Methods in Molecular Biology 2521 (3): 317-328. 23 June 2022

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker.
Schmid, F., Dahlmann, M., Röhrich, H., Kobelt, D., Hoffmann, J., Burock, S., Walther, W. and Stein, U.
British Journal of Cancer 127 (4): 675-685. 1 September 2022

Dissecting the intracellular pancreatic tumor microbiome at single-cell level.
Schmidt, T.S.B. and Bork, P.
Cancer Cell 40 (10): 1083-1085. 10 October 2022

Drivers and determinants of strain dynamics following fecal microbiota transplantation.
Schmidt, T.S.B., Li, S.S., Maistrenko, O.M., Akanni, W., Coelho, L.P., Dolai, S., Fullam, A., Glazek, A.M., Hercog, R., Herrema, H., Jung, F., Kandels, S., Orakov, A., Thielemann, R., von Stetten, M., Van Rossum, T., Benes, V., Borody, T.J., de Vos, W.M., Ponsioen, C.Y., Nieuwdorp, M. and Bork, P.
Nature Medicine 28 (9): 1902-1912. September 2022

Senescence and cancer - role and therapeutic opportunities.
Schmitt, C.A., Wang, B. and Demaria, M.
Nature Reviews Clinical oncology 19 (10): 619–636. October 2022

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours.
Schubert, N.A., Chen, C.Y., Rodríguez, A., Koster, J., Dowless, M., Pfister, S.M., Shields, D.J., Stancato, L.F., Vassal, G., Caron, H.N., van den Boogaard, M.L., Henssen, A.G. and Molenaar, J.J.
European Journal of Cancer 170 : 196-208. July 2022

On the relation between input and output distributions of scRNA-seq experiments.
Schwabe, D. and Falcke, M.
Bioinformatics 38 (5): 1336-1343. 1 March 2022

Graph neural networks for learning molecular excitation spectra.
Singh, K., Münchmeyer, J., Weber, L., Leser, U. and Bande, A.
Journal of Chemical Theory and Computation 18 (7): 4408-4417. 12 July 2022

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors.
Specker, E., Matthes, S., Wesolowski, R., Schütz, A., Grohmann, M., Alenina, N., Pleimes, D., Mallow, K., Neuenschwander, M., Gogolin, A., Weise, M., Pfeifer, J., Ziebart, N., Heinemann, U., von Kries, J.P., Nazaré, M. and Bader, M.
Journal of Medicinal Chemistry 65 (16): 11126-11149. 25 August 2022

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas.
Staudacher, J.J., Arnold, A., Kühl, A.A., Pötzsch, M., Daum, S., Winterfeld, M., Berg, E., Hummel, M., Rau, B., Stein, U. and Treese, C.
BMC Cancer 22 (1): 953. 5 September 2022

DLBCL 1L-what to expect beyond R-CHOP?
Stegemann, M., Denker, S. and Schmitt, C.A.
Cancers 14 (6): 1453. 11 March 2022

Pan-claudin family interactome analysis reveals shared and specific interactions.
Suarez Artiles, L., Breiderhoff, T., Girardello, R., Gonschior, H., Rodius, S., Lesur, A., Reimer, U., Ramberger, E., Perez-Hernandez, D., Müller, D., Mertins, P. and Dittmar, G.
Cell Reports 41 (6): 111588. 8 November 2022

Skeletal muscle derived Musclin protects the heart during pathological overload.
Szaroszyk, M., Kattih, B., Martin-Garrido, A., Trogisch, F.A., Dittrich, G.M., Grund, A., Abouissa, A., Derlin, K., Meier, M., Holler, T., Korf-Klingebiel, M., Völker, K., Macedo, T.G., Tortola, C.P., Boschmann, M., Huang, N., Froese, N., Zwadlo, C., Malek Mohammadi, M., Luo, X., Wagner, M., Cordero, J., Geffers, R., Batkai, S., Thum, T., Bork, N., Nikolaev, V.O., Müller, O.J., Katus, H.A., El-Armouche, A., Kraft, T., Springer, J., Dobreva, G., Wollert, K.C., Fielitz, J., von Haehling, S., Kuhn, M., Bauersachs, J. and Heineke, J.
Nature Communications 13 (1): 149. 10 January 2022

Genomic evolution and personalized therapy of an infantile fibrosarcoma harboring an NTRK oncogenic fusion.
Thorwarth, A., Haase, K., Röefzaad, C., Pajtler, K.W., Schramm, K., Hauptmann, K., Behnke, A., Vokuhl, C., Elgeti, T., Gratopp, A., Schulte, J.H., Scheer, M., Hernáiz Driever, P., Nysom, K., Eggert, A., Henssen, A.G. and Deubzer, H.E.
JCO Precision Oncology 6 : e2100283. 25 May 2022

S100A4 is a strong negative prognostic marker and potential therapeutic target in adenocarcinoma of the stomach and esophagus.
Treese, C., Hartl, K., Pötzsch, M., Dahlmann, M., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., Rau, B., Walther, W., Daum, S., Kobelt, D. and Stein, U.
Cells 11 (6): 1056. 21 March 2022

Inhibition of MACC1-induced metastasis in esophageal and gastric adenocarcinomas.
Treese, C., Werchan, J., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., Rau, B., Daberkow, O., Walther, W., Daum, S., Kobelt, D. and Stein, U.
Cancers 14 (7): 1773. 31 March 2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

Time-keeping and decision-making in living cells: Part II.
Tyson, J.J., Csikasz-Nagy, A., Gonze, D., Kim, J.K., Santos, S. and Wolf, J.
Interface Focus 12 (4): 20220024. 10 June 2022

Time-keeping and decision-making in living cells: Part I.
Tyson, J.J., Csikasz-Nagy, A., Gonze, D., Kim, J.K., Santos, S. and Wolf, J.
Interface Focus 12 (3): 20220011. 6 June 2022

Detection and validation of circular DNA fragments using nanopore sequencing.
Tüns, A.I., Hartmann, T., Magin, S., Chamorro González, R., Henssen, A.G., Rahmann, S., Schramm, A. and Köster, J.
Frontiers in Genetics 13 : 867018. 30 May 2022

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Ventura, P.M.O., Gakovic, M., Fischer, B.A., Spinelli, L., Rota, G., Pathak, S., Khameneh, H.J., Zenobi, A., Thomson, S., Birchmeier, W., Cantrell, D.A. and Guarda, G.
EMBO Reports 23 (11): e55399. 7 November 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083. 2 June 2022

Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival.
Vuaroqueaux, V., Musch, A., Kobelt, D., Risch, T:, Herrmann, P., Burock, S., Peille, A.L., Yaspo, M.L., Fiebig, H.H. and Stein, U.
Cancers 14 (7): 1749. 1 April 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R., Pallien, T., Miller, D.C., Oder, A., Neuenschwander, M., von Kries, J.P., Diecke, S. and Klussmann, E.
Methods in Molecular Biology 2483 : 117-139. 2022

Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C., Polovitskaya, M.M., Delgado, B.D., Jentsch, T.J. and Long, S.B.
Science Advances 8 (5): eabm3942. 2 February 2022

Chemical-protein relation extraction with ensembles of carefully tuned pretrained language models.
Weber, L., Sänger, M., Garda, S., Barth, F., Alt, C. and Leser, U.
Database 2022 : baac098. 18 November 2022

Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10 (11): 1407-1419. 1 November 2022

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke, A.C., Doebele, C., Zindel, A., Lee, K.S., Rieke, S.A., Ceribelli, M., Comoglio, F., Phelan, J.D., Wang, J.Q., Pikman, Y., Jahn, D., Häupl, B., Schneider, C., Scheich, S., Tosto, F.A., Bohnenberger, H., Stauder, P., Schnütgen, F., Slabicki, M., Coulibaly, Z.A., Wolf, S., Bojarczuk, K., Chapuy, B., Brandts, C.H., Stroebel, P., Lewis, C.A., Engelke, M., Xu, X., Kim, H., Dang, T.H., Schmitz, R., Hodson, D.J., Stegmaier, K., Urlaub, H., Serve, H., Schmitt, C.A., Kreuz, F., Knittel, G., Rabinowitz, J.D., Reinhardt, H.C., Vander Heiden, M.G., Thomas, C., Staudt, L.M., Zenz, T. and Oellerich, T.
Blood 139 (4): 538-553. 27 January 2022

The transcription factor EB (TFEB) sensitizes the heart to chronic pressure overload.
Wundersitz, S., Pablo Tortola, C., Schmidt, S., Oliveira Vidal, R., Kny, M., Hahn, A., Zanders, L., Katus, H.A., Sauer, S., Butter, C., Luft, F.C., Müller, O.J. and Fielitz, J.
International Journal of Molecular Sciences 23 (11): 5943. 25 May 2022

Radiofrequency electromagnetic fields cause non-temperature-induced physical and biological effects in cancer cells.
Wust, P., Veltsista, P.D., Oberacker, E., Yavvari, P., Walther, W., Bengtsson, O., Sterner-Kock, A., Weinhart, M., Heyd, F., Grabowski, P., Stintzing, S., Heinrich, W., Stein, U. and Ghadjar, P.
Cancers 14 (21): 5349. 30 October 2022

Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M., Yu, H., Yu, X., Liang, S., Hu, Y., Luo, Y., Izsvák, Z., Sun, C. and Wang, J.
Cell Stem Cell 29 (3): 400-418.e13. 3 March 2022

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
Yao, Y., Du Jiang, P., Chao, B.N., Cagdas, D., Kubo, S., Balasubramaniyam, A., Zhang, Y., Shadur, B., NaserEddin, A., Folio, L.R., Schwarz, B., Bohrnsen, E., Zheng, L., Lynberg, M., Gottlieb, S., Leney-Greene, M.A., Park, A.Y., Tezcan, I., Akdogan, A., Gocmen, R., Onder, S., Rosenberg, A., Soilleux, E.J., Johnson, E., Jackson, P.K., Demeter, J., Chauvin, S.D., Paul, F., Selbach, M., Bulut, H., Clatworthy, M.R., Tuong, Z.K., Zhang, H., Stewart, B.J., Bosio, C.M., Stepensky, P., Clare, S., Ganesan, S., Pascall, J.C., Daumke, O., Butcher, G.W., McMichael, A.J., Simon, A.K. and Lenardo, M.J.
Journal of Experimental Medicine 219 (6): e20201405. 6 June 2022

Extrachromosomal DNA amplifications in cancer.
Yi, E., Chamorro González, R., Henssen, A.G. and Verhaak, R.G.W.
Nature Reviews Genetics 23 (12): 760-771. December 2022

Recapitulating early human development with 8C-like cells.
Yu, X., Liang, S., Chen, M., Yu, H., Li, R., Qu, Y., Kong, X., Guo, R., Zheng, R., Izsvak, Z., Sun, C., Yang, M. and Wang, J.
Cell Reports 39 (12): 110994. 21 June 2022

Proton-gated anion transport governs macropinosome shrinkage.
Zeziulia, M., Blin, S., Schmitt, F.W., Lehmann, M. and Jentsch, T.J.
Nature Cell Biology 24 (6): 885-895. June 2022

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D., Borsa, M., Puleston, D.J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S.S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G. and Simon, A.K.
Nature Communications 13 (1): 5174. 2 September 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C.H., Müller, S., Mastrobuoni, G., Hazapis, O.G., Del Giudice, S., Schwefel, D., Bley, N., Voigt, F., Chao, J.A., Kempa, S., Hüttelmaier, S., Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G., Vanzo, R., Amitash, S., Martín-Doncel, E., Coscia, F., Mund, A., Lerdrup, M., Benada, J., Boos, D. and Toledo, L.
Molecular Cell 82 (18): 3350-3365. 15 September 2022

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V., Rusha, E., Shaposhnikov, D., Ruiz-Orera, J., Telugu, N., Rishko, V., Hayashi, M., Michel, G., Wittler, L., Stejskal, J., Holtze, S., Göritz, F., Hermes, R., Wang, J., Izsvák, Z., Colleoni, S., Lazzari, G., Galli, C., Hildebrandt, T.B., Hayashi, K., Diecke, S. and Drukker, M.
Scientific Reports 12 (1): 3100. 8 March 2022

SMOG 2 and OpenSMOG: extending the limits of structure-based models.
de Oliveira, A.B., Contessoto, V.G., Hassan, A., Byju, S., Wang, A., Wang, Y., Dodero-Rojas, E., Mohanty, U., Noel, J.K., Onuchic, J.N. and Whitford, P.C.
Protein Science 31 (1): 158-172. January 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E., Brückner, L. and Henssen, A.G.
Nature Genetics 54 (2): 107-114. February 2022

2021

A role for STOML3 in olfactory sensory transduction.
Agostinelli, E., Gonzalez-Velandia, K.Y., Hernandez-Clavijo, A., Maurya, D.K., Xerxa, E., Lewin, G.R., Dibattista, M., Menini, A. and Pifferi, S.
eNeuro 8 (2): ENEURO.0565-20.2021. 26 March 2021

From operating table to laboratory bench: the path toward metastasis research from the clinical setting.
Alberto Vilchez, M. and Rau, B.
Methods in Molecular Biology 2294 : 325-333. 2021

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation.
Alisch, M., Kerkering, J., Crowley, T., Rosiewicz, K., Paul, F. and Siffrin, V.
Journal of Neuroscience Methods 361 : 109284. 1 September 2021

Vasopressin-vermittelte Wasserrückresorption im Sammelrohr der Niere [Vasopressin-mediated water reabsorption in the renal collecting duct].
Baltzer, S. and Klussmann, E.
BIOspektrum 27 (2): 165-167. March 2021

Hearing and vocalizations in the naked mole-rat.
Barker, A.J., Koch, U., Lewin, G.R. and Pyott, S.J.
Advances in Experimental Medicine and Biology 1319 (1319): 157-195. 24 August 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J., Veviurko, G., Bennett, N.C., Hart, D.W., Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy.
Bascuas, T., Kropp, M., Harmening, N., Wong, B.M., Johnen, S., Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments (168): e62145. 26 February 2021

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

Viewpoints on the first transatlantic GPCR symposium for early-career investigators.
Bender, B.J., Bock, A., Nesheva, D.N. and Perry-Hauser, N.A.
ACS Pharmacology & Translational Science 4 (5): 1705-1711. 8 October 2021

CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N., Eckstein, J., Wallach, I., Nordmeyer, S., Kelm, M., Kirchner, M., Goubergrits, L., Schafstedde, M., Hennemuth, A., Kraus, M., Grune, T., Mertins, P., Kuehne, T. and Holzhütter, H.G.
Circulation 144 (24): 1926-1939. 14 December 2021

Cerebral EBV-positive PTLD controlled by PD-1 checkpoint blockade in a liver transplant patient.
Bittner, A., Radke, J., Eurich, D., Wiener, E., Denker, S., Anagnostopoulos, I., Na, I.K., Heppner, F.L., Bullinger, L. and Schmitt, C.A.
Leukemia & Lymphoma 62 (8): 2026-2029. August 2021

Allosteric coupling and biased agonism in G protein-coupled receptors.
Bock, A. and Bermudez, M.
FEBS Journal 288 (8): 2513-2528. April 2021

Quantitative spectroscopy of single molecule interaction times.
Boltz, H.H., Sirbu, A., Stelzer, N., Lohse, M.J., Schütte, C. and Annibale, P.
Optics Letters 46 (7): 1538-1541. 1 April 2021

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
Breitkreuz-Korff, O., Tscheik, C., Del Vecchio, G., Dithmer, S., Walther, W., Orthmann, A., Wolburg, H., Haseloff, R.F., Schröder, L., Blasig, I.E. and Winkler, L.
Journal of Controlled Release 330 : 137-148. 10 August 2021

NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Brischetto, C., Krieger, K., Klotz, C., Krahn, I., Kunz, S., Kolesnichenko, M., Mucka, P., Heuberger, J., Scheidereit, C. and Schmidt-Ullrich, R.
Development 148 (21): dev199683. November 2021

Mitochondria in neurogenesis: implications for mitochondrial diseases.
Brunetti, D., Dykstra, W., Le, S., Zink, A. and Prigione, A.
Stem Cells 39 (10): 1289-1297. October 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann, J., Lorenz, C., Borchmann, S., Nishii, K., Wegner, J., Meder, L., Ostendorp, J., Ast, D.F., Heimsoeth, A., Nakasuka, T., Hirabae, A., Okawa, S., Dammert, M.A., Plenker, D., Klein, S., Lohneis, P., Gu, J., Godfrey, L.K., Forster, J., Trajkovic-Arsic, M., Zillinger, T., Haarmann, M., Quaas, A., Lennartz, S., Schmiel, M., D'Rozario, J., Thomas, E.S., Li, H., Schmitt, C.A., George, J., Thomas, R.K., von Karstedt, S., Hartmann, G., Büttner, R., Ullrich, R.T., Siveke, J.T., Ohashi, K., Schlee, M. and Sos, M.L.
Nature Communications 12 (1): 5505. 17 September 2021

Structural evidence of active site adaptability towards different sized substrates of aromatic amino acid aminotransferase from Psychrobacter sp. B6.
Bujacz, A., Rum, J., Rutkiewicz, M., Pietrzyk-Brzezinska, A.J. and Bujacz, G.
Materials 14 (12): 3351. 2 June 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Cancer stem cells: advances in biology and clinical translation -- a Keystone Symposia report.
Cable, J., Pei, D., Reid, L.M., Wang, X.W., Bhatia, S., Karras, P., Melenhorst, J.J., Grompe, M., Lathia, J.D., Song, E., Kuo, C.J., Zhang, N., White, R.M., Ma, S.K., Ma, L., Chin, Y.R., Shen, M.M., Ng, I.O.L., Kaestner, K.H., Zhou, L., Sikandar, S., Schmitt, C.A., Guo, W., Wong, C.C.L., Ji, J., Tang, D.G., Dubrovska, A., Yang, C., Wiedemeyer, W.R. and Weissman, I.L.
Annals of the New York Academy of Sciences 1506 (1): 142–163. December 2021

Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences.
Carli, M., Kolachalam, S., Longoni, B., Pintaudi, A., Baldini, M., Aringhieri, S., Fasciani, I., Annibale, P., Maggio, R. and Scarselli, M.
Pharmaceuticals 14 (3): 238. March 2021

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer.
Carter, D.M., Specker, E., Malecki, P.H., Przygodda, J., Dudaniec, K., Weiss, M.S., Heinemann, U., Nazaré, M. and Gohlke, U.
Journal of Medicinal Chemistry 64 (19): 14266-14282. 14 October 2021

Functional characterization of ovine dorsal root ganglion neurons reveal peripheral sensitization after osteochondral defect.
Chakrabarti, S., Ai, M., Wong, K., Newell, K., Henson, F.M.D. and Smith, E.S.J.
eNeuro 8 (5): ENEURO.0237-21.2021. September 2021

FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua, J.Y., Ng, S.J., Yagensky, O., Wanker, E.E. and Chua, J.J.E.
eNeuro 8 (2): ENEURO.0193-20.2021. 26 March 2021

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules.
Cipriani, P.G., Bay, O., Zinno, J., Gutwein, M., Gan, H.H., Mayya, V.K., Chung, G., Chen, J.X., Fahs, H., Guan, Y., Duchaine, T.F., Selbach, M., Piano, F. and Gunsalus, K.C.
eLife 10 : e60833. 3 August 2021

Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann, M., Gambara, G., Brzezicha, B., Popp, O., Pachmayr, E., Wedeken, L., Pflaume, A., Mokritzkij, M., Gül-Klein, S., Brandl, A., Schweiger-Eisbacher, C., Mertins, P., Hoffmann, J., Keilholz, U., Walther, W., Regenbrecht, C., Rau, B. and Stein, U.
Molecular Cancer 20 (1): 129. 21 October 2021

A bioinformatic pipeline to identify biomarkers for metastasis formation from RNA sequencing data.
Dahlmann, M. and Stein, U.S.
Methods in Molecular Biology 2294 : 221-238. 2021

Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data.
Dimchev, G., Amiri, B., Fäßler, F., Falcke, M. and Schur, F.K.M.
Journal of Structural Biology 213 (4): 107808. December 2021

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M., Klinger, B., Mari, T., Toedling, J., Blanc, E., Messerschmidt, C., Nadler-Holly, M., Ziehm, M., Sieber, A., Hertwig, F., Beule, D., Eggert, A., Schulte, J.H., Selbach, M. and Blüthgen, N.
PLoS Computational Biology 17 (11): e1009515. 4 November 2021

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Duncan, A.R., Polovitskaya, M.M., Gaitán-Peñas, H., Bertelli, S., VanNoy, G.E., Grant, P.E., O'Donnell-Luria, A., Valivullah, Z., Lovgren, A.K., England, E.M., Agolini, E., Madden, J.A., Schmitz-Abe, K., Kritzer, A., Hawley, P., Novelli, A., Alfieri, P., Colafati, G.S., Wieczorek, D., Platzer, K., Luppe, J., Koch-Hogrebe, M., Abou Jamra, R., Neira-Fresneda, J., Lehman, A., Boerkoel, C.F., Seath, K., Clarke, L., van Ierland, Y., Argilli, E., Sherr, E.H., Maiorana, A., Diel, T., Hempel, M., Bierhals, T., Estévez, R., Jentsch, T.J., Pusch, M. and Agrawal, P.B.
American Journal of Human Genetics 108 (8): 1450-1465. 5 August 2021

Surface AMP deaminase 2 as a novel regulator modifying extracellular adenine nucleotide metabolism.
Ehlers, L., Kuppe, A., Damerau, A., Wilantri, S., Kirchner, M., Mertins, P., Strehl, C., Buttgereit, F. and Gaber, T.
FASEB Journal 35 (7): e21684. July 2021

Thymoquinone: a tie-breaker in SARS-CoV2-infected cancer patients?
Elgohary, S., Elkhodiry, A.A., Amin, N.S., Stein, U. and El Tayebi, H.M.
Cells 10 (2): 302. 2 February 2021

Imlifidase as novel treatment strategy in anti-neutrophil cytoplasmic antibody–induced pulmonary-renal syndrome.
Enghard, P., Zickler, D., Sonnemann, J., Schneider, W., Lurje, G., Elezkurtaj, S., Eckardt, K.U. and Schreiber, A.
Kidney International 100 (6): 1344-1345. December 2021

Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J.P., Petzold, G.C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N.J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D.E., Bonvento, G., Butt, A.M., Chen, W.T., Cohen-Salmon, M., Cunningham, C., Deneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J.E., Goldman, S.A., Götz, M., Gutiérrez, A., Haydon, P.G., Heiland, D.H., Hol, E.M., Holt, M.G., Iino, M., Kastanenka, K.V., Kettenmann, H., Khakh, B.S., Koizumi, S., Lee, C.J., Liddelow, S.A., MacVicar, B.A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A.V., Murai, K.K., Norris, C.M., Okada, S., Oliet, S.H.R., Oliveira, J.F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B.G., Pfrieger, F.W., Poskanzer, K.E., Quintana, F.J., Ransohoff, R.M., Riquelme-Perez, M., Robel, S., Rose, C.R., Rothstein, J.D., Rouach, N., Rowitch, D.H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R.A., Vitorica, J., Wanner, I.B., Wood, L.B., Wu, J., Zheng, B., Zimmer, E.R., Zorec, R., Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24 (3): 312-325. March 2021

Stochastic reaction-diffusion modeling of calcium dynamics in 3D-dendritic spines of purkinje cells.
Friedhoff, V.N., Antunes, G., Falcke, M. and Simões de Souza, F.M.
Biophysical Journal 120 (11): 2112-2123. 1 June 2021

Models of stochastic Ca(2+) spiking : established approaches and inspirations from models of neuronal spikes.
Friedhoff, V.N., Ramlow, L., Lindner, B. and Falcke, M.
European Physical Journal Special Topics 230 (16-17): 2911-2928. October 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C., Schallenberg, S., Kirchner, M., Ziehm, M., Niquet, S., Haji, M., Beier, C., Neudecker, J., Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

Use of cement suspension as an alternative matrix material for textile-reinforced concrete.
Fürst, R., Fürst, E., Vlach, T., Řepka, J., Pokorný, M. and Mózer, V.
Materials 14 (9): 2127. 1 May 2021

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.A., Carus-Cadavieco, M., Korotkova, T., Tzingounis, A.V., Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12 (1): 4801. 10 August 2021

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A., Roske, Y., Yamada, S., Uehata, T., Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49 (9): 5369-5381. 21 May 2021

Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
Gebert, J., Gelincik, O., Oezcan-Wahlbrink, M., Marshall, J.D., Hernandez-Sanchez, A., Urban, K., Long, M., Cortes, E., Tosti, E., Katzenmaier, E.M., Song, Y., Elsaadi, A., Deng, N., Vilar, E., Fuchs, V., Nelius, N., Yuan, Y.P., Ahadova, A., Sei, S., Shoemaker, R.H., Umar, A., Wei, L., Liu, S., Bork, P., Edelmann, W., von Knebel Doeberitz, M., Lipkin, S.M. and Kloor, M.
Gastroenterology 161 (4): 288-1302.e13. October 2021

Identifying cell-type-specific metabolic signatures using transcriptome and proteome analyses.
Gebert, N., Rahman, S., Lewis, C.A., Ori, A. and Cheng, C.W.
Current Protocols 1 (9): e245. 28 September 2021

Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
Gillissen, B., Richter, A., Essmann, F. and Kemmner, W.
BMC Cancer 21 (1): 971. 30 August 2021

Editorial: Monocyte heterogeneity and function.
Ginhoux, F., Mildner, A., Gautier, E.L., Schlitzer, A., Jakubzick, C., Varol, C., Bain, C. and Guermonprez, P.
Frontiers in Immunology 11 : 626725. 7 January 2021

MLL1 is required for maintenance of intestinal stem cells.
Goveas, N., Waskow, C., Arndt, K., Heuberger, J., Zhang, Q., Alexopoulou, D., Dahl, A., Birchmeier, W., Anastassiadis, K., Stewart, A.F. and Kranz, A.
PLoS Genetics 17 (12): e1009250. 3 December 2021

The need for sustainable leadership in academia : a survey of academics in Germany shows a lack of and a great demand for training in leadership skills.
Haage, V., Voss, L., Nguyen, D. and Eggert, F.
EMBO Reports 22 (12): e53592. 6 December 2021

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P., Mustroph, J., Stauber, T., Birchmeier, W., Wagner, S. and Maier, L.S.
PLoS ONE 16 (6): e0252649. 4 June 2021

Timed global reorganization of protein synthesis during neocortex neurogenesis at codon resolution.
Harnett, D., Ambrozkiewicz, M.C., Zinnall, U., Borisova, E., Rusanova, A., Dannenberg, R., Imami, K., Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M., Landthaler, M., Spahn, C.M.T., Tarabykin, V., Ohler, U. and Kraushar, M.L.
bioRxiv : 2021.06.23.449626. 24 June 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A., Sieverling, L., Nadler-Holly, M., Ziehm, M., Toprak, U.H., Herrmann, C., Ishaque, N., Okonechnikov, K., Gartlgruber, M., Park, Y.G., Wecht, E.M., Savelyeva, L., Henrich, K.O., Rosswog, C., Fischer, M., Hero, B., Jones, D.T.W., Pfaff, E., Witt, O., Pfister, S.M., Volckmann, Ri., Koster, J., Kiesel, K., Rippe, K., Taschner-Mandl, S., Ambros, P., Brors, B., Selbach, M., Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Insulin-like growth factor binding protein-2 (IGFBP2) is a key molecule in the MACC1-mediated platelet communication and metastasis of colorectal cancer cells.
Haschemi, R., Kobelt, D., Steinwarz, E., Schlesinger, M., Stein, U. and Bendas, G.
International Journal of Molecular Sciences 22 (22): 12195. 11 November 2021

Cold-shock domains - abundance, structure, properties, and nucleic-acid binding.
Heinemann, U. and Roske, Y.
Cancers 13 (2): 190. 7 January 2021

Dual-color fluorescence cross-correlation spectroscopy to study protein-protein interaction and protein dynamics in live cells.
Hemmen, K., Choudhury, S., Friedrich, M., Balkenhol, J., Knote, F., Lohse, M.J. and Heinze, K.G.
Journal of Visualized Experiments 178 : e62954. 11 December 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F., Gossmann, T.I., Frioux, C., Özkurt, E., Myers, P.N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H.B. and Bork, P.
Cell Host & Microbe 29 (7): 1167-1176. 14 June 2021

Glial cell line‐derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia‐mediated glioma progression.
Huang, Y., Zhang, B., Haneke, H., Haage, V., Lubas, M., Yuan, Y., Xia, P., Motta, E., Nanvuma, C., Dzaye, O., Hu, F. and Kettenmann, H.
Journal of Neuroscience Research 99 (4): 1048-1063. April 2021

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L., Yost, K.E., Xie, L., Shi, Q., Helmsauer, K., Luebeck, J., Schöpflin, R., Lange, J.T., Chamorro González, R., Weiser, N.E., Chen, C., Valieva, M.E., Wong, I.T.L., Wu, S., Dehkordi, S.R., Duffy, C.V., Kraft, K., Tang, J., Belk, J.A., Rose, J.C., Corces, M.R., Granja, J.M., Li, R., Rajkumar, U., Friedlein, J., Bagchi, A., Satpathy, A.T., Tjian, R., Mundlos, S., Bafna, V., Henssen, A.G., Mischel, P.S., Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F., Dahlmann, M., Sporbert, A., Ciolli Mattioli, C., Mari, T., Scholz, F., Timm, L., Twamley, S., Migotti, R., Walther, W., Dittmar, G., Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Bioenergetic profiling of human pluripotent stem cells.
Inak, G., Henke, M.T. and Prigione, A.
Methods in Molecular Biology 2277 : 391-403. 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold.
Irmscher, T., Roske, Y., Gayk, I., Dunsing, V., Chiantia, S., Heinemann, U. and Barbirz, S.
Journal of Biological Chemistry 296 : 100286. 2021

Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A., Serfling, R., Möller, J., Thomas, R., De Faveri, C., Zabel, U., Scarselli, M., Beck-Sickinger, A.G., Bock, A., Coin, I., Lohse, M.J. and Annibale, P.
Nature Protocols 16 (3): 1419-1451. March 2021

Electroporation-based genetic modification of primary human pigment epithelial cells using the Sleeping Beauty transposon system.
Johnen, S., Harmening, N., Marie, C., Scherman, D., Izsvák, Z., Ivics, Z., Walter, P. and Thumann, G.
Journal of Visualized Experiments (168): e61987. February 2021

Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser, R., Leunig, A., Pekayvaz, K., Popp, O., Joppich, M., Polewka, V., Escaig, R., Anjum, A., Hoffknecht, M.L., Gold, C., Brambs, S., Engel, A., Stockhausen, S., Knottenberg, V., Titova, A., Haji, M., Scherer, C., Muenchhoff, M., Hellmuth, J.C., Saar, K., Schubert, B., Hilgendorff, A., Schulz, C., Kääb, S., Zimmer, R., Hübner, N., Massberg, S., Mertins, P., Nicolai, L. and Stark, K.
JCI Insight 6 (18): e150862. 22 September 2021

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N., Roske, Y., Kovalskyy, D., Platonov, M.O., Balinskyi, O., Kreuchwig, A., Saupe, J., Fang, L., Diehl, A., Schmieder, P., Krause, G., Rademann, J., Heinemann, U., Birchmeier, W. and Oschkinat, H.
Magnetic Resonance 2 (1): 355-374. 2 June 2021

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M., Subramaniam, S., Chomsky-Hecht, O., Tsemakhovich, V., Flockerzi, V., Klussmann, E., Hirsch, J.A., Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K., Kaljunen, H., Taavitsainen, S., Kaarijärvi, R., Järvelä, E., Rodriguez Martin, B., Haase, K., Woodcock, D.J., Tubio, J., Wedge, D.C., Nykter, M. and Bova, G.S.
Cancer Research 81 (19): 4901-4909. October 2021

Glial cells: neuroglia.
Kettenmann, H. and Verkhratsky, A.
In: Neuroscience in the 21st century : from basic to clinical. Springer, New York, NY, 1-36. ISBN 978-1-4614-6434-1 12 April 2021

UNC93B1 is widely expressed in the murine CNS and is required for neuroinflammation and neuronal injury induced by microRNA let-7b.
Klammer, M.G., Dzaye, O., Wallach, T., Krüger, C., Gaessler, D., Buonfiglioli, A., Derkow, K., Kettenmann, H., Brinkmann, M.M. and Lehnardt, S.
Frontiers in Immunology 12 : 715774. September 2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
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Bioaccumulation of therapeutic drugs by human gut bacteria.
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The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis.
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Real-time cell migration monitoring to analyze drug synergism in the scratch assay using the IncuCyte system.
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Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
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Fluorine ((19)F) MRI for assessing inflammatory cells in the kidney: experimental protocol.
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An oscillatory network controlling self-renewal of skeletal muscle stem cells.
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Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers.
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Generation of human brain organoids for mitochondrial disease modeling.
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Virus-induced senescence is driver and therapeutic target in COVID-19.
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Nature 599 : 283-289. 11 November 2021

Technologies for profiling the impact of genomic variants on transcription factor binding.
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Medizinische Genetik 33 (2): 147-155. 14 August 2021

The somatosensory world of the African naked mole-rat.
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Advances in Experimental Medicine and Biology 1319 (1319): 197-220. 24 August 2021

Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice.
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Blood Advances 5 (5): 1239-1249. 9 March 2021

Coupling proteomics and metabolomics for the unsupervised identification of protein-metabolite interactions in Chaetomium thermophilum.
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PLoS ONE 16 (7): e0254429. 9 July 2021

Systematic identification of MACC1-driven metabolic networks in colorectal cancer.
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Cancers 13 (5): 978. 26 February 2021

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.
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Cell 184 (14): 3660-3673. 8 July 2021

Microglia sense neuronal activity via GABA in the early postnatal hippocampus.
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Cell Reports 37 (13): 110128. 28 December 2021

Genetic background but not intestinal microbiota after co-housing determines hyperoxaluria-related nephrocalcinosis in common inbred mouse strains.
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Frontiers in Immunology 12 : 673423. 21 April 2021

A simple spatial-independent associative and reversal learning task in mice.
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3D MRI of explanted sheep hearts with submillimeter isotropic spatial resolution: comparison between diffusion tensor and structure tensor imaging.
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Magnetic Resonance Materials in Physics Biology and Medicine 34 (5): 741-755. October 2021

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
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Journal of Cachexia Sarcopenia and Muscle 12 : 1249-1265. 14 October 2021

Unravelling the collateral damage of antibiotics on gut bacteria.
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Nature 599 : 120-124. 4 November 2021

Humoral and cellular immune responses in SARS-CoV-2 mRNA-vaccinated patients with cancer.
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Cancer Cell 39 (9): 1171-1172. 13 September 2021

GAS1 is required for Notch-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.
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Development 148 (21): dev200080. 11 November 2021

The rise of proteome-wide biophysics.
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Molecular Systems Biology 17 (7): e10442. July 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.
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Development 148 (17): dev199307. September 2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
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Cell Reports 37 (4): 109878. 26 October 2021

Phenylalanine-hydroxylase contributes to serotonin synthesis in mice.
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FASEB Journal 35 (6): e21648. June 2021

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.
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Nature Cell Biology 23 (10): 1073-1084. October 2021

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
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Molecular Cell 81 (6): 1200-1215. 18 March 2021

Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K., Teranishi, K., Ambroso, M.R., Isas, J.M., Vazquez-Sarandeses, E., Lee, J.Y., Melo, A.A., Pandey, P., Merken, D., Berndt, L., Lammers, M., Daumke, O., Chang, K., Haworth, I.S. and Langen, R.
Nature Communications 12 (1): 6466. 9 November 2021

GUNC: detection of chimerism and contamination in prokaryotic genomes.
Orakov, A., Fullam, A., Coelho, L.P., Khedkar, S., Szklarczyk, D., Mende, D.R., Schmidt, T.S.B. and Bork, P.
Genome Biology 22 (1): 178. 13 June 2021

Activation of tripartite motif containing 63 expression by transcription factor EB and transcription factor binding to immunoglobulin heavy chain enhancer 3 is regulated by protein kinase D and class IIa histone deacetylases.
Pablo Tortola, C., Fielitz, B., Li, Y., Rüdebusch, J., Luft, F.C. and Fielitz, J.
Frontiers in Physiology 11 : 550506. 13 January 2021

Effective oncoleaking treatment of pancreatic cancer by claudin-targeted suicide gene therapy with Clostridium perfringens enterotoxin (CPE).
Pahle, J., Kobelt, D., Aumann, J., Behrens, D., Daberkow, O., Mokritzkij, M., Piontek, J., Stein, U. and Walther, W.
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Uncharted biosynthetic potential of the ocean microbiome.
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bioRxiv : 2021.03.24.436479. 24 March 2021

African naked mole-rats demonstrate extreme tolerance to hypoxia and hypercapnia.
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Advances in Experimental Medicine and Biology 1319 (1319): 255-269. 24 August 2021

Community-wide experimental evaluation of the PROSS stability-design method.
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Journal of Molecular Biology 433 (13): 166964. 25 June 2021

Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites.
Philippot, C., Griemsmann, S., Jabs, R., Seifert, G., Kettenmann, H. and Steinhäuser, C.
Cell Reports 34 (3): 108642. 19 January 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C., Starke, L., Ramspoth, T.F., Kerkering, J., Martos Riaño, V., Paul, J., Neuenschwander, M., Oder, A., Radetzki, S., Adelhoefer, S., Ramos Delgado, P., Aravina, M., Millward, J.M., Fillmer, A., Paul, F., Siffrin, V., von Kries, J.P., Niendorf, T., Nazaré, M. and Waiczies, S.
ACS Sensors 6 (11): 3948–3956. 26 November 2021

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
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Cancer Research 81 (8): 2116-2127. April 2021

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
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A universal peptide matrix interactomics approach to disclose motif dependent protein binding.
Ramberger, E., Suarez-Artiles, L., Perez-Hernandez, D., Haji, M., Popp, O., Reimer, U., Leutz, A., Dittmar, G. and Mertins, P.
Molecular & Cellular Proteomics 20 : 100135. 13 August 2021

Early days of tenascin-R research: two approaches discovered and shed light on tenascin-R.
Rathjen, F.G. and Hodge, R.
Frontiers in Immunology 11 : 612482. 8 January 2021

Expanding the phenotype of NUP85 mutations beyond nephrotic syndrome to primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders.
Ravindran, E., Jühlen, R., Vieira-Vieira, C.H., Ha, T., Salzberg, Y., Fichtman, B., Luise-Becker, L., Martins, N., Picker-Minh, S., Bessa, P., Arts, P., Jackson, M.R., Taranath, A., Kamien, B., Barnett, C., Li, N., Tarabykin, V., Stoltenburg-Didinger, G., Harel, A., Selbach, M., Dickmanns, A., Fahrenkrog, B., Hu, H., Scott, H. and Kaindl, A.M.
Human Molecular Genetics 30 (22): 2068-2081. 15 November 2021

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Regina, C., Hamed, E., Andrieux, G., Angenendt, S., Schneider, M., Ku, M., Follo, M., Wachtel, M., Ke, E., Kikuchi, K., Henssen, A.G., Schäfer, B.W., Boerries, M., Wagers, A.J., Keller, C. and Hettmer, S.
Life Science Alliance 4 (9): e202001002. September 2021

A sweet story of metabolic innovation in the naked mole-rat.
Reznick, J., Park, T.J. and Lewin, G.R.
Advances in Experimental Medicine and Biology 1319 (1319): 271-286. 24 August 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I., Poon, E., Henssen, A.G., Dorado Garcia, H., Gatti, M., Giansanti, C., Jamin, Y., Ade, C.P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

A versatile sub-nanomolar fluorescent ligand enables NanoBRET binding studies and single-molecule microscopy at the histamine H(3) receptor.
Rosier, N., Grätz, L., Schihada, H., Möller, J., Işbilir, A., Humphrys, L.J., Nagl, M., Seibel, U., Lohse, M.J. and Pockes, S.
Journal of Medicinal Chemistry 64 (15): 11695-11708. 12 August 2021

Compendium of 530 metagenome-assembled bacterial and archaeal genomes from the polar Arctic Ocean.
Royo-Llonch, M., Sánchez, P., Ruiz-González, C., Salazar, G., Pedrós-Alió, C., Sebastián, M., Labadie, K., Paoli, L., M. Ibarbalz, F., Zinger, L., Churcheward, B., Chaffron, S., Eveillard, D., Karsenti, E., Sunagawa, S., Wincker, P., Karp-Boss, L., Bowler, C. and Acinas, S.G.
Nature Microbiology 6 (12): 1561-1574. December 2021

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Rössler, U., Hennig, A.F., Stelzer, N., Bose, S., Kopp, J., Søe, K., Cyganek, L., Zifarelli, G., Ali, S., von der Hagen, M., Strässler, E.T., Hahn, G., Pusch, M., Stauber, T., Izsvák, Z., Gossen, M., Stachelscheid, H. and Kornak, U.
Journal of Bone and Mineral Research 36 (8): 1621-1635. August 2021

Reduction of cortical parvalbumin expressing GABAergic interneurons in a rodent hyperoxia model of preterm birth brain injury with deficits in social behavior and cognition.
Scheuer, T., Auf dem Brinke, E., Grosser, S., Wolf, S.A., Mattei, D., Sharkovska, Y., Barthel, P.C., Endesfelder, S., Friedrich, V., Bührer, C., Vida, I. and Schmitz, T.
Development 148 (20): dev.198390. October 2021

Bioluminescence in G protein-coupled receptors drug screening using nanoluciferase and halo-tag technology.
Schihada, H., Nemec, K., Lohse, M.J. and Maiellaro, I.
Methods in Molecular Biology 2268 : 137-147. 2021

Small, seeding-competent huntingtin fibrils are prominent aggregate species in brains of zQ175 Huntington's disease knock-in mice.
Schindler, F., Praedel, N., Neuendorf, N., Kunz, S., Schnoegl, S., Mason, M.A., Taxy, B.A., Bates, G.P., Khoshnan, A., Priller, J., Grimm, J., Maier, M., Boeddrich, A. and Wanker, E.E.
Frontiers in Neuroscience 15 : 682172. 22 June 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J., Huska, M., Cwikla, M.C., Kruetzfeldt, L.M., Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y., Burkert, M., Guergen, D., Szymansky, A., Astrahantseff, K., Kuenkele, A., Haase, K., Fischer, M., Deubzer, H.E., Hertwig, F., Hundsdoerfer, P., Henssen, A.G., Schwarz, R.F., Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Drivers and determinants of strain dynamics following faecal microbiota transplantation.
Schmidt, T.S.B., Li, S.S., Maistrenko, O.M., Akanni, W., Coelho, L.P., Dolai, S., Fullam, A., Glazek, A.M., Hercog, R., Herrema, H., Jung, F., Kandels, S., Orakov, A., Van Rossum, T., Benes, V., Borody, T.J., de Vos, W.M., Ponsioen, C.Y., Nieuwdorp, M. and Bork, P.
bioRxiv : 2021.09.30.462010. 30 September 2021

On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
Schreiber, C., Amiri, B., Heyn, J.C.J., Rädler, J.O. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 118 (4): e2009959118. 26 January 2021

CellFIE: CRISPR- and cell fusion-based two-hybrid interaction mapping of endogenous proteins.
Secker, C., Kostova, S., Niederlechner, H., Beetz, S., Wendland, I., Liebich, M.J., Polzer, O., Groh, M., Schnoegl, S., Trepte, P. and Wanker, E.E.
Journal of Molecular Biology 433 (24): 167305. 3 December 2021

Structural and functional characterization of allatostatin receptor type-C of Thaumetopoea pityocampa, a potential target for next-generation pest control agents.
Shahraki, A., Işbilir, A., Dogan, B., Lohse, M.J., Durdagi, S. and Birgul-Iyison, N.
Journal of Chemical Information and Modeling 61 (2): 715-728. 22 February 2021

Local cyclic adenosine monophosphate signalling cascades - roles and targets in chronic kidney disease.
Sholokh, A. and Klussmann, E.
Acta Physiologica 232 (1): e13641. May 2021

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva, E., Stadiotti, I., Casella, M., Catto, V., Dello Russo, A., Carbucicchio, C., Arnaboldi, L., De Metrio, S., Milano, G., Scopece, A., Casaburo, M., Andreini, D., Mushtaq, S., Conte, E., Chiesa, M., Birchmeier, W., Cogliati, E., Paolin, A., König, E., Meraviglia, V., De Musso, M., Volani, C., Cattelan, G., Rauhe, W., Turnu, L., Porro, B., Pedrazzini, M., Camera, M., Corsini, A., Tondo, C., Rossini, A. and Pompilio, G.
EMBO Molecular Medicine 13 (9): e14365. 7 September 2021

Preface.
Stein, U.S.
Methods in Molecular Biology 2294 : v. 2021

Inhibiting lysine demethylase 1A improves L1CAM-specific CAR T cell therapy by unleashing antigen-independent killing via the FAS-FASL axis.
Sulejmani, O., Grunewald, L., Andersch, L., Schwiebert, S., Klaus, A., Winkler, A., Astrahantseff, K., Eggert, A., Henssen, A.G., Schulte, J.H., Anders, K. and Künkele, A.
Cancers 13 (21): 5489. 31 October 2021

Neuroblastoma risk assessment and treatment stratification with hybrid capture-based panel sequencing.
Szymansky, A., Kruetzfeldt, L.M., Heukamp, L.C., Hertwig, F., Theissen, J., Deubzer, H.E., Willing, E.M., Menon, R., Fuchs, S., Thole, T., Schulte, S., Schmelz, K., Künkele, A., Lang, P., Fuchs, J., Eggert, A., Eckert, C., Fischer, M., Henssen, A.G., Rodriguez-Fos, E. and Schulte, J.H.
Journal of Personalized Medicine 11 (8): 691. August 2021

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A., Grunewald, L., Anders, K., Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G., Höpken, U.E., Eggert, A., Schulte, J.H., Jensen, M.C., Blankenstein, T. and Künkele, A.
Cancers 13 (5): 1050. 2 March 2021

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
Thibado, J.K, Tano, J.Y., Lee, J., Salas-Estrada, L., Provasi, D., Strauss, A., Ribeiro, J.M.L., Xiang, G., Broichhagen, J., Filizola, M., Lohse, M.J. and Levitz, J.
eLife 10 : e67027. 21 April 2021

Patient-specific modeling of diffuse large B-cell lymphoma.
Thobe, K., Konrath, F., Chapuy, B. and Wolf, J.
Biomedicines 9 (11): 1655. 10 November 2021

Cl(-) channels and Cl(-)/H(+) exchangers.
Ullrich, F. and Jentsch, T.J.
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 470-477. ISBN 978-3-030-57400-0 2021

A previously undescribed highly prevalent phage identified in a Danish Enteric Virome Catalog.
Van Espen, L., Bak, E.G., Beller, L., Close, L., Deboutte, W., Juel, H.B., Nielsen, T., Sinar, D., De Coninck, L., Frithioff-Bøjsøe, C., Fonvig, C.E., Jacobsen, S., Kjærgaard, M., Thiele, M., Fullam, A., Kuhn, M., Holm, J.C., Bork, P., Krag, A., Hansen, T., Arumugam, M. and Matthijnssens, J.
mSystems 6 (5): e00382-21. 26 October 2021

Insulin mRNA is stored in RNA granules in resting beta cells.
Vasiljević, J., Vasiljević, D., Ganß, K., Sönmez, A., Wegbrod, C., Quezada, E., Münster, C., Schöniger, E., Friedland, D., Kipke, N., Distler, M., Selbach, M. and Solimena, M.
bioRxiv : 2021.05.07.443159. 29 June 2021

Opportunities and challenges in global quantification of RNA-protein interaction via UV cross-linking.
Vieira-Vieira, C.H. and Selbach, M.
Frontiers in Molecular Biosciences 8 : 669939. 13 May 2021

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E.
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 78-83. ISBN 978-3-030-57400-0 2021

Extend, don’t rebuild: Phrasing conditional graph modification as autoregressive sequence labelling.
Weber, L., Münchmeyer, J., Garda, S. and Leser, U.
In: 2021 Conference on Empirical Methods in Natural Language Processing, EMNLP 2021, 7-11 Nov 2021, Punta Cana, Dominican Republic. November 2021

HunFlair: an easy-to-use tool for state-of-the-art biomedical named entity recognition.
Weber, L., Sänger, M., Münchmeyer, J., Habibi, M., Leser, U. and Akbik, A.
Bioinformatics 37 (17): 2792–2794. 1 September 2021

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I.L., Mittermaier, M., Mache, C., Chua, R.L., Knoll, R., Timm, S., Brumhard, S., Krammer, T., Zauber, H., Hiller, A.L., Pascual-Reguant, A., Mothes, R., Bülow, R.D., Schulze, J., Leipold, A.M., Djudjaj, S., Erhard, F., Geffers, R., Pott, F., Kazmierski, J., Radke, J., Pergantis, P., Baßler, K., Conrad, C., Aschenbrenner, A.C., Sawitzki, B., Landthaler, M., Wyler, E., Horst, D., Hippenstiel, S., Hocke, A., Heppner, F.L., Uhrig, A., Garcia, C., Machleidt, F., Herold, S., Elezkurtaj, S., Thibeault, C., Witzenrath, M., Cochain, C., Suttorp, N., Drosten, C., Goffinet, C., Kurth, F., Schultze, J.L., Radbruch, H., Ochs, M., Eils, R., Müller-Redetzky, H., Hauser, A.E., Luecken, M.D., Theis, F.J., Conrad, C., Wolff, T., Boor, P., Selbach, M., Saliba, A.E. and Sander, L.E.
Cell 184 (26): 6243-6261. 22 December 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.
Wirbel, J., Zych, K., Essex, M., Karcher, N., Kartal, E., Salazar, G., Bork, P., Sunagawa, S. and Zeller, G.
Genome Biology 22 (1): 93. 30 March 2021

Patient-derived xenografts from solid tumors (PDX) for models of metastasis.
Wulf-Goldenberg, A., Hoffmann, J., Becker, M., Brzezicha, B. and Walther, W.
Methods in Molecular Biology 2294 : 43-58. 2021

Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology.
Wust, P., Stein, U. and Ghadjar, P.
International Journal of Hyperthermia 38 (1): 715-731. 28 April 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E., Mösbauer, K., Franke, V., Diag, A., Gottula, L.T., Arsiè, R., Klironomos, F., Koppstein, D., Hönzke, K., Ayoub, S., Buccitelli, C., Hoffmann, K., Richter, A., Legnini, I., Ivanov, A., Mari, T., Del Giudice, S., Papies, J., Praktiknjo, S., Meyer, T.F., Müller, M.A., Niemeyer, D., Hocke, A., Selbach, M., Akalin, A., Rajewsky, N., Drosten, C. and Landthaler, M.
iScience 24 (3): 102151. 19 March 2021

Histamine triggers microglial responses indirectly via astrocytes and purinergic signaling.
Xia, P., Logiacco, F., Huang, Y., Kettenmann, H. and Semtner, M.
Glia 69 (9): 2291-2304. September 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y., Lahmann, I., Baum, K., Shimojo, H., Mourikis, P., Wolf, J., Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

A simple pressure-assisted method for MicroED specimen preparation.
Zhao, J., Xu, H., Lebrette, H., Carroni, M., Taberman, H., Högbom, M. and Zou, X.
Nature Communications 12 (1): 5036. 19 August 2021

Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders.
Zink, A., Lisowski, P. and Prigione, A.
Bio-protocol 11 (5): e3939. 5 March 2021

An introduction to advanced targeted acquisition methods.
van Bentum, M. and Selbach, M.
Molecular & Cellular Proteomics 20 : 100165. 18 October 2021

This list was generated on Sat Oct 12 09:37:27 2024 UTC.
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