Items where Year is 2021

Article

Mapping the human genetic architecture of COVID-19.

Nature 600 (7889): 472-477. December 2021

COVID-19 highlights the model dilemma in biomedical research.
Adhikary, P.P. and Ul Ain, Q. and Hocke, A.C. and Hedtrich, S.
Nature Reviews Materials 6 (5): 374-376. 2021

A role for STOML3 in olfactory sensory transduction.
Agostinelli, E. and Gonzalez-Velandia, K.Y. and Hernandez-Clavijo, A. and Maurya, D.K. and Xerxa, E. and Lewin, G.R. and Dibattista, M. and Menini, A. and Pifferi, S.
eNeuro 8 (2): ENEURO.0565-20.2021. 26 March 2021

Serum glial fibrillary acidic protein: a neuromyelitis optica spectrum disorder biomarker.
Aktas, O. and Smith, M.A. and Rees, W.A. and Bennett, J.L. and She, D. and Katz, E. and Cree, B.A.C.
Annals of Neurology 89 (5): 895-910. May 2021

Measuring myocardial extracellular volume of the right ventricle in patients with congenital heart disease.
Al-Wakeel-Marquard, N. and Ferreira da Silva, T. and Jeuthe, S. and Rastin, S. and Muench, F. and O H-Ici, D. and Yilmaz, S. and Berger, F. and Kuehne, T. and Messroghli, D.R.
Scientific Reports 11 (1): 2679. 29 January 2021

Diffuse myocardial fibrosis by T1 mapping is associated with heart failure in pediatric primary dilated cardiomyopathy.
Al-Wakeel-Marquard, N. and Seidel, F. and Herbst, C. and Kühnisch, J. and Kuehne, T. and Berger, F. and Klaassen, S. and Messroghli, D.R.
International Journal of Cardiology 333 : 219-225. 15 June 2021

Angiotensin 1-7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle.
Albadrani, H. and Ammar, T. and Bader, M. and Renaud, J.M.
Journal of General Physiology 153 (12): e201912556. 6 December 2021

From operating table to laboratory bench: the path toward metastasis research from the clinical setting.
Alberto Vilchez, M. and Rau, B.
Methods in Molecular Biology 2294 : 325-333. 2021

Spontaneous non-sustained ventricular tachycardia and premature ventricular contractions and their prognostic relevance in patients with cancer in routine care.
Albrecht, A. and Porthun, J. and Eucker, J. and Coats, A.J.S. and von Haehling, S. and Pezzutto, A. and Karakas, M. and Riess, H. and Keller, U. and Landmesser, U. and Haverkamp, W. and Anker, S.D. and Anker, M.S.
Cancers 13 (10): 2303. 12 May 2021

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Alcalá-Vida, R. and Seguin, J. and Lotz, C. and Molitor, A.M. and Irastorza-Azcarate, I. and Awada, A. and Karasu, N. and Bombardier, A. and Cosquer, B. and Skarmeta, J.L.G. and Cassel, J.C. and Boutillier, A.L. and Sexton, T. and Merienne, K.
Nature Communications 12 (1): 364. 13 January 2021

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation.
Alisch, M. and Kerkering, J. and Crowley, T. and Rosiewicz, K. and Paul, F. and Siffrin, V.
Journal of Neuroscience Methods 361 : 109284. 1 September 2021

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
Allou, L. and Balzano, S. and Magg, A. and Quinodoz, M. and Royer-Bertrand, B. and Schöpflin, R. and Chan, W.L. and Speck-Martins, C.E. and Carvalho, D.R. and Farage, L. and Lourenço, C.M. and Albuquerque, R. and Rajagopal, S. and Nampoothiri, S. and Campos-Xavier, B. and Chiesa, C. and Niel-Bütschi, F. and Wittler, L. and Timmermann, B. and Spielmann, M. and Robson, M.I. and Ringel, A. and Heinrich, V. and Cova, G. and Andrey, G. and Prada-Medina, C.A. and Pescini-Gobert, R. and Unger, S. and Bonafé, L. and Grote, P. and Rivolta, C. and Mundlos, S. and Superti-Furga, A.
Nature 592 (7852): 93-98. 1 April 2021

A novel investigation method for axonal damage in neuromyelitis optica spectrum disorder: In vivo corneal confocal microscopy.
Altıntaş, A. and Yildiz-Tas, A. and Yilmaz, S. and Bayraktutar, B.N. and Comert, M.C. and Zimmermann, H. and Brandt, A.U. and Paul, F. and Sahin, A.
Multiple Sclerosis Journal Experimental Translational and Clinical 7 (1): 2055217321998060. 1 January 2021

Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein.
Alves, D.T. and Mendes, L.F. and Sampaio, W.O. and Coimbra-Campos, L.M.C. and Vieira, M.A.R. and Ferreira, A.J. and Martins, A.S. and Popova, E. and Todiras, M. and Qadri, F. and Alenina, N. and Bader, M. and Santos, R.A.S. and Campagnole-Santos, M.J.
Clinical Science 135 (18): 2197-2216. 8 September 2021

Feasibility of a culturally adapted dietary weight-loss intervention among Ghanaian migrants in Berlin, Germany: the ADAPT study.
Amoah, S. and Ennin, R. and Sagoe, K. and Steinbrecher, A. and Pischon, T. and Mockenhaupt, F.P. and Danquah, I.
International Journal of Environmental Research and Public Health 18 (2): 510. 9 January 2021

Putative mobilized colistin resistance genes in the human gut microbiome.
Andrade, B.G.N. and Goris, T. and Afli, H. and Coutinho, F.H. and Dávila, A.M.R. and Cuadrat, R.R.C.
BMC Microbiology 21 : 220. 22 July 2021

Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J. and Shi, C. and Costa, A.S.H. and Choi, J. and Kim, J. and Doddaballapur, A. and Sugino, T. and Ong, Y.T. and Castro, M. and Zimmermann, B. and Kaulich, M. and Guenther, S. and Wilhelm, K. and Kubota, Y. and Braun, T. and Koh, G.Y. and Grosso, A.R. and Frezza, C. and Potente, M.
Nature Cell Biology 23 : 413-423. April 2021

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M. and Franke, V. and Bruno, M. and Grishkovskaya, I. and Kasiliauskaite, A. and Kaufmann, T. and Schoeberl, U.E. and Puchinger, M.G. and Kostrhon, S. and Ebenwaldner, C. and Sebesta, M. and Beltzung, E. and Mechtler, K. and Lin, G. and Vlasova, A. and Leeb, M. and Pavri, R. and Stark, A. and Akalin, A. and Stefl, R. and Bernecky, C. and Djinovic-Carugo, K. and Slade, D.
Nature Communications 12 (1): 6078. 19 October 2021

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt, B. and Mastrobuoni, G. and Wuenschel, J. and Astrahantseff, K. and Eggert, A. and Kempa, S. and Deubzer, H.E.
Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1): 1282-1289. 30 June 2021

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, B. and Zasada, C. and Baum, K. and Wuenschel, J. and Mastrobuoni, G. and Lodrini, M. and Astrahantseff, K. and Winkler, A. and Schulte, J.H. and Finkler, S. and Forbes, M. and Hundsdoerfer, P. and Guergen, D. and Hoffmann, J. and Wolf, J. and Eggert, A. and Kempa, S. and Deubzer, H.E.
International Journal of Cancer 148 (5): 1219-1232. 1 March 2021

SNT: a unifying toolbox for quantification of neuronal anatomy.
Arshadi, C. and Günther, U. and Eddison, M. and Harrington, K.I.S. and Ferreira, T.A.
Nature Methods 18 : 374-377. April 2021

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling.
Asaro, A. and Sinha, R. and Bakun, M. and Kalnytska, O. and Carlo-Spiewok, A.S. and Rubel, T. and Rozeboom, A. and Dadlez, M. and Kaminska, B. and Aronica, E. and Malik, A.R. and Willnow, T.E.
Journal of Cell Science 134 (20): jcs258894. 15 October 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Aslam, M.A. and Alemdehy, M.F. and Kwesi-Maliepaard, E.M. and Muhaimin, F.I. and Caganova, M. and Pardieck, I.N. and van den Brand, T. and van Welsem, T. and de Rink, I. and Song, J.Y. and de Wit, E. and Arens, R. and Jacobs, H. and van Leeuwen, F.
EMBO Reports 22 (2): e51184. 3 February 2021

Pain, depression and quality of life in adults with MOG-antibody associated disease.
Asseyer, S. and Henke, E. and Trebst, C. and Hümmert, M.W. and Wildemann, B. and Jarius, S. and Ringelstein, M. and Aktas, O. and Pawlitzki, M. and Korsen, M. and Klotz, L. and Siebert, N. and Ruprecht, K. and Bellmann-Strobl, J. and Wernecke, K.D. and Häußler, V. and Havla, J. and Gahlen, A. and Gold, R. and Paul, F. and Kleiter, I. and Ayzenberg, I.
European Journal of Neurology 28 (5): 1645-1658. May 2021

AQP4-IgG autoimmunity in Japan and Germany: differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders.
Asseyer, S. and Masuda, H. and Mori, M. and Bellmann-Strobl, J. and Ruprecht, K. and Siebert, N. and Cooper, G. and Chien, C. and Duchow, A. and Schließeit, J. and Liu, J. and Sugimoto, K. and Uzawa, A. and Ohtani, R. and Paul, F. and Brandt, A.U. and Kuwabara, S. and Zimmermann, H.G.
Multiple Sclerosis Journal Experimental Translational and Clinical 7 (2): 205521732110068. 1 April 2021

Acceleration of TAA-induced liver fibrosis by stress exposure is associated with upregulation of nerve growth factor and glycopattern deviations.
Atorrasagasti, C. and Piccioni, F. and Borowski, S. and Tirado-González, I. and Freitag, N. and Cantero, M.J. and Bayo, J. and Mazzolini, G. and Alaniz, L.D. and Blois, S.M. and Garcia, M.G.
International Journal of Molecular Sciences 22 (10): 5055. 11 May 2021

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.
Audain, E. and Wilsdon, A. and Breckpot, J. and Izarzugaza, J.M. and Fitzgerald, T.W. and Kahlert, A.K. and Sifrim, A. and Wünnemann, F. and Perez-Riverol, Y. and Abdul-Khaliq, H. and Bak, M. and Bassett, A.S. and Benson, W.D. and Berger, F. and Daehnert, I. and Devriendt, K. and Dittrich, S. and Daubeney, P.E. and Garg, V. and Hackmann, K. and Hoff, K. and Hofmann, P. and Dombrowsky, G. and Pickardt, T. and Bauer, U. and Keavney, B.D. and Klaassen, S. and Kramer, H.H. and Marshall, C.R. and Milewicz, D.M. and Lemaire, S. and Coselli, J.S. and Mitchell, M.E. and Tomita-Mitchell, A. and Prakash, S.K. and Stamm, K. and Stewart, A.F.R. and Silversides, C.K. and Siebert, R. and Stiller, B. and Rosenfeld, J.A. and Vater, I. and Postma, A.V. and Caliebe, A. and Brook, J.D. and Andelfinger, G. and Hurles, M.E. and Thienpont, B. and Larsen, L.A. and Hitz, M.P.
PLoS Genetics 17 (7): e1009679. 29 July 2021

Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study.
Augustin, M. and Schommers, P. and Stecher, M. and Dewald, F. and Gieselmann, L. and Gruell, H. and Horn, C. and Vanshylla, K. and Cristanziano, V.D. and Osebold, L. and Roventa, M. and Riaz, T. and Tschernoster, N. and Altmueller, J. and Rose, L. and Salomon, S. and Priesner, V. and Luers, J.C. and Albus, C. and Rosenkranz, S. and Gathof, B. and Fätkenheuer, G. and Hallek, M. and Klein, F. and Suárez, I. and Lehmann, C.
The Lancet Regional Health - Europe 6 : 100122. July 2021

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P. and Song, T. and Yao, Y. and Fehlner-Peach, H. and Diamond, B. and Gu, H. and Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118 (30): e2100576118. 27 July 2021

APOSTEL 2.0 recommendations for reporting quantitative optical coherence tomography studies.
Aytulun, A. and Cruz-Herranz, A. and Aktas, O. and Balcer, L.J. and Balk, L. and Barboni, P. and Blanco, A.A. and Calabresi, P.A. and Costello, F. and Sanchez-Dalmau, B. and DeBuc, D.C. and Feltgen, N. and Finger, R.P. and Frederiksen, J.L. and Frohman, E. and Frohman, T. and Garway-Heath, D. and Gabilondo, I. and Graves, J.S. and Green, A.J. and Hartung, H.P. and Havla, J. and Holz, F.G. and Imitola, J. and Kenney, R. and Klistorner, A. and Knier, B. and Korn, T. and Kolbe, S. and Krämer, J. and Lagrèze, W.A. and Leocani, L. and Maier, O. and Martínez-Lapiscina, E.H. and Meuth, S. and Outteryck, O. and Paul, F. and Petzold, A. and Pihl-Jensen, G. and Preiningerova, J.L. and Rebolleda, G. and Ringelstein, M. and Saidha, S. and Schippling, S. and Schuman, J.S. and Sergott, R.C. and Toosy, A. and Villoslada, P. and Wolf, S. and Yeh, E.A. and Yu-Wai-Man, P. and Zimmermann, H.G. and Brandt, A.U. and Albrecht, P.
Neurology 97 (2): 68-79. 13 July 2021

Pain, depression, and quality of life in neuromyelitis optica spectrum disorder: a cross-sectional study of 166 AQP4 antibody-seropositive patients.
Ayzenberg, I. and Richter, D. and Henke, E. and Asseyer, S. and Paul, F. and Trebst, C. and Hümmert, M.W. and Havla, J. and Kümpfel, T. and Ringelstein, M. and Aktas, O. and Wildemann, B. and Jarius, S. and Häußler, V. and Stellmann, J.P. and Senel, M. and Klotz, L. and Pellkofer, H.L. and Weber, M.S. and Pawlitzki, M. and Rommer, P.S. and Berthele, A. and Wernecke, K.D. and Hellwig, K. and Gold, R. and Kleiter, I.
Neurology Neuroimmunology & Neuroinflammation 8 (3): e985. May 2021

Metagenomic assessment of the global diversity and distribution of bacteria and fungi.
Bahram, M. and Netherway, T. and Frioux, C. and Ferretti, P. and Coelho, L.P. and Geisen, S. and Bork, P. and Hildebrand, F.
Environmental Microbiology 23 (1): 316-326. January 2021

Ultra-rapid emergency genomic diagnosis of Donahue syndrome in a preterm infant within 17 hours.
Bamborschke, D. and Özdemir, Ö. and Kreutzer, M. and Motameny, S. and Thiele, H. and Kribs, A. and Dötsch, J. and Altmüller, J. and Nürnberg, P. and Cirak, S.
American Journal of Medical Genetics A 185 (1): 90-96. January 2021

Extracellular matrix in heart Failure: role of ADAMTS5 in proteoglycan remodeling.
Barallobre-Barreiro, J. and Radovits, T. and Fava, M. and Mayr, U. and Lin, W.Y. and Ermolaeva, E. and Martínez-López, D. and Lindberg, E.L. and Duregotti, E. and Daróczi, L. and Hasman, M. and Schmidt, L.E. and Singh, B. and Lu, R. and Baig, F. and Siedlar, A.M. and Cuello, F. and Catibog, N. and Theofilatos, K. and Shah, A.M. and Crespo-Leiro, M.G. and Doménech, N. and Hübner, N. and Merkely, B. and Mayr, M.
Circulation 144 (25): 2021-2034. 21 December 2021

Hearing and vocalizations in the naked mole-rat.
Barker, A.J. and Koch, U. and Lewin, G.R. and Pyott, S.J.
Advances in Experimental Medicine and Biology 1319 (1319): 157-195. 24 August 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J. and Veviurko, G. and Bennett, N.C. and Hart, D.W. and Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P. and Birkner, T. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Mähler, A. and Weber, D. and Kochlik, B. and Balogh, A. and Wilck, N. and Boschmann, M. and Müller, D.N. and Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy.
Bascuas, T. and Kropp, M. and Harmening, N. and Wong, B.M. and Johnen, S. and Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments (168): e62145. 26 February 2021

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions.
Bassani, B. and Tripodo, C. and Portararo, P. and Gulino, A. and Botti, L. and Chiodoni, C. and Jachetti, E. and Bolli, N. and Ciciarello, M. and Joehrens, K. and Anagnostopoulos, I. and Na, I.K. and Curti, A. and Colombo, M.P. and Sangaletti, S.
Frontiers in Immunology 12 : 662048. 18 May 2021

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day.
Basti, A. and Yalçin, M. and Herms, D. and Hesse, J. and Aboumanify, O. and Li, Y. and Aretz, Z. and Garmshausen, J. and El-Athman, R. and Hastermann, M. and Blottner, D. and Relógio, A.
BMJ Open Sport & Exercise Medicine 7 (1): e000876. 10 February 2021

Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk.
Bastos de Oliveira, M. and Meier, K. and Jung, S. and Bartels-Klein, E. and Coxam, B. and Geudens, I. and Szymborska, A. and Skoczylas, R. and Fechner, I. and Koltowska, K. and Gerhardt, H.
Development 148 (4): dev194993. 19 February 2021

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M. and Gmach, P. and Boltz, H.H. and Einsiedel, J. and Gotthardt, M. and Hübner, H. and Gmeiner, P. and Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

A backward-mode optical-resolution photoacoustic microscope for 3D imaging using a planar Fabry-Pérot sensor.
Baumann, E. and Pohle, U. and Zhang, E. and Allen, T. and Villringer, C. and Pulwer, S. and Gerhardt, H. and Laufer, J.
Photoacoustics 24 : 100293. December 2021

Protein intake, metabolic status and the gut microbiota in different ethnicities: results from two independent cohorts.
Bel Lassen, P. and Attaye, I. and Adriouch, S. and Nicolaou, M. and Aron-Wisnewsky, J. and Nielsen, T. and Chakaroun, R. and Le Chatelier, E. and Forslund, S. and Belda, E. and Bork, P. and Bäckhed, F. and Stumvoll, M. and Pedersen, O. and Herrema, H. and Groen, A. and Pinto-Sietsma, S.J. and Zwinderman, A. and Nieuwdorp, M. and Clement, K.
Nutrients 13 (9): 3159. September 2021

Epigallocatechin gallate in relapsing-remitting multiple sclerosis: a randomized, placebo-controlled trial.
Bellmann-Strobl, J. and Paul, F. and Wuerfel, J. and Dörr, J. and Infante-Duarte, C. and Heidrich, E. and Körtgen, B. and Brandt, A. and Pfüller, C. and Radbruch, H. and Rust, R. and Siffrin, V. and Aktas, O. and Heesen, C. and Faiss, J. and Hoffmann, F. and Lorenz, M. and Zimmermann, B. and Groppa, S. and Wernecke, K.D. and Zipp, F.
Neurology Neuroimmunology & Neuroinflammation 8 (3): e981. May 2021

Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham, R. and Litchfield, K. and Watkins, T.B.K. and Lim, E.L. and Rosenthal, R. and Martínez-Ruiz, C. and Hiley, C.T. and Bakir, M.A. and Salgado, R. and Moore, D.A. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature 597 (7877): 555-560. 23 September 2021

Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography.
Berger, C. and Ravelli, R.B.G. and López-Iglesias, C. and Kudryashev, M. and Diepold, A. and Peters, P.J.
Journal of Structural Biology 213 (1): 107701. March 2021

Deep tissue scattering compensation with three-photon F-SHARP.
Berlage, C. and Tantirigama, M.L.S. and Babot, M. and Di Battista, D. and Whitmire, C. and Papadopoulos, I.N. and Poulet, J.F.A. and Larkum, M. and Judkewitz, B.
Optica 8 (12): 1613-1619. 20 December 2021

Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis.
Bernardo-Faura, M. and Rinas, M. and Wirbel, J. and Pertsovskaya, I. and Pliaka, V. and Messinis, D.E. and Vila, G. and Sakellaropoulos, T. and Faigle, W. and Stridh, P. and Behrens, J.R. and Olsson, T. and Martin, R. and Paul, F. and Alexopoulos, L.G. and Villoslada, P. and Saez-Rodriguez, J.
Genome Medicine 13 (1): 117. 16 July 2021

CARDIOKIN1: computational assessment of myocardial metabolic capability in healthy controls and patients with valve diseases.
Berndt, N. and Eckstein, J. and Wallach, I. and Nordmeyer, S. and Kelm, M. and Kirchner, M. and Goubergrits, L. and Schafstedde, M. and Hennemuth, A. and Kraus, M. and Grune, T. and Mertins, P. and Kuehne, T. and Holzhütter, H.G.
Circulation 144 (24): 1926-1939. 14 December 2021

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques.
Bewley, K.R. and Gooch, K. and Thomas, K.M. and Longet, S. and Wiblin, N. and Hunter, L. and Chan, K. and Brown, P. and Russell, R. A. and Ho, C. and Slack, G. and Humphries, H.E. and Alden, L. and Allen, L. and Aram, M. and Baker, N. and Brunt, E. and Cobb, R. and Fotheringham, S. and Harris, D. and Kennard, C. and Leung, S. and Ryan, K. and Tolley, H. and Wand, N. and White, A. and Sibley, L. and Sarfas, C. and Pearson, G. and Rayner, E. and Xue, X. and Lambe, T. and Charlton, S. and Gilbert, S. and Sattentau, Q.J. and Gleeson, F. and Hall, Y. and Funnell, S. and Sharpe, S. and Salguero, F.J. and Gorringe, A. and Carroll, M.
Science Advances 7 (37): eabg7996. 10 September 2021

Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki, P. and Riesenfeld, S.J. and Hütter, J.C. and Torlai Triglia, E. and Kowalczyk, M.S. and Ricardo-Gonzalez, R.R. and Lian, M. and Amezcua Vesely, M.C. and Kroehling, L. and Xu, H. and Slyper, M. and Muus, C. and Ludwig, L.S. and Christian, E. and Tao, L. and Kedaigle, A.J. and Steach, H.R. and York, A.G. and Skadow, M.H. and Yaghoubi, P. and Dionne, D. and Jarret, A. and McGee, H.M. and Porter, C.B.M. and Licona-Limón, P. and Bailis, W. and Jackson, R. and Gagliani, N. and Gasteiger, G. and Locksley, R.M. and Regev, A. and Flavell, R.A.
Nature 592 (7852): 128-132. 1 April 2021

Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort.
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Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma.
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Time to diagnosis in multiple sclerosis: epidemiological data from the German Multiple Sclerosis Registry.
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Progressive myocardial injury in myotonic dystrophy type II and facioscapulohumeral muscular dystrophy 1: a cardiovascular magnetic resonance follow-up study.
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Uncovering de novo gene birth in yeast using deep transcriptomics.
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Nature Communications 12 (1): 604. 27 January 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
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Nature Communications 12 (1): 5395. 13 September 2021

Placental glycoredox dysregulation associated with disease progression in an animal model of superimposed preeclampsia.
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Cells 10 (4): 800. April 2021

Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation.
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Scientific Reports 11 (1): 7404. 1 April 2021

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
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Nature Communications 12 (1): 3965. 25 June 2021

Phenotyping placental oxygenation in Lgals1 deficient mice using (19)F MRI.
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Scientific Reports 11 (1): 2126. 22 January 2021

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma.
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Blood Advances 5 (9): 2391-2402. 11 May 2021

Quantitative spectroscopy of single molecule interaction times.
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Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
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Clinical and Translational Allergy 11 (5): e12045. July 2021

PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial.
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Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.
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Nature Communications 12 (1): 2715. 11 May 2021

Impact of a specialised palliative care intervention in patients with advanced soft tissue sarcoma - a single-centre retrospective analysis.
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BMC Palliative Care 20 (1): 16. 14 January 2021

Association of a marker of N-acetylglucosamine with progressive multiple sclerosis and neurodegeneration.
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JAMA Neurology 78 (7): 842-852. July 2021

M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
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Journal of Controlled Release 330 : 137-148. 10 August 2021

DOTAM-based, targeted, activatable fluorescent probes for the highly sensitive and selective detection of cancer cells.
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Bioconjugate Chemistry 32 (4): 702-712. 21 April 2021

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
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Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo.
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Neoplasia 23 (1): 80-98. January 2021

NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
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Development 148 (21): dev199683. November 2021

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila.
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Mitochondria in neurogenesis: implications for mitochondrial diseases.
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Stem Cells 39 (10): 1289-1297. October 2021

Radiation driven chemistry in biomolecules -- is (V)UV involved in the bioactivity of argon jet plasmas?
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Frontiers in Physics 9 : 759005. 14 December 2021

Coregulation of gene expression by White collar 1 and phytochrome in Ustilago maydis.
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Fungal Genetics and Biology 152 : 103570. July 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
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Nature Communications 12 (1): 5505. 17 September 2021

Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage.
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Journal of Biological Chemistry 297 (4): 101224. October 2021

DenoiSeg: joint denoising and segmentation.
Buchholz, T.O. and Prakash, M. and Schmidt, D. and Krull, A. and Jug, F.
Lecture Notes in Computer Science 12535 : 324-337. 10 January 2021

Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.
Buchumenski, I. and Holler, K. and Appelbaum, L. and Eisenberg, E. and Junker, J.P. and Levanon, E.Y.
Nucleic Acids Research 49 (8): 4325-4337. 7 May 2021

Structural evidence of active site adaptability towards different sized substrates of aromatic amino acid aminotransferase from Psychrobacter sp. B6.
Bujacz, A. and Rum, J. and Rutkiewicz, M. and Pietrzyk-Brzezinska, A.J. and Bujacz, G.
Materials 14 (12): 3351. 2 June 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K. and Kny, M. and Huang, N. and Klassert, T.E. and Stock, M. and Hahn, A. and Graeger, S. and Todiras, M. and Schmidt, S. and Chamling, B. and Willenbrock, M. and Groß, S. and Biedenweg, D. and Heuser, A. and Scheidereit, C. and Butter, C. and Felix, S.B. and Otto, O. and Luft, F.C. and Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Gene therapy "Made in Germany": a historical perspective, analysis of the status quo, and recommendations for action by the German Society for Gene Therapy.
Büning, H. and Fehse, B. and Ivics, Z. and Kochanek, S. and Koehl, U. and Kupatt, C. and Mussolino, C. and Nettelbeck, D.M. and Schambach, A. and Uckert, W. and Wagner, E. and Cathomen, T.
Human Gene Therapy 32 (19-20): 987-996. 18 October 2021

Single cell biology - a Keystone Symposia report.
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Annals of the New York Academy of Sciences 1506 (1): 74-97. December 2021

Cancer stem cells: advances in biology and clinical translation -- a Keystone Symposia report.
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Annals of the New York Academy of Sciences 1506 (1): 142–163. December 2021

The delivery challenge of genome editing in human epithelia.
Calderón, M. and Hedtrich, S.
Advanced Healthcare Materials 10 (19): e2100847. October 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Wilkins, K. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49 (9): 5336-5350. May 2021

Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca(2+) entry after pressure-overload induced cardiac remodelling.
Camacho Londoño, J.E. and Kuryshev, V. and Zorn, M. and Saar, K. and Tian, Q. and Hübner, N. and Nawroth, P. and Dietrich, A. and Birnbaumer, L. and Lipp, P. and Dieterich, C. and Freichel, M.
Progress in Biophysics and Molecular Biology 159 : 86-104. January 2021

Hydrogels containing budesonide-loaded nanoparticles to facilitate percutaneous absorption for atopic dermatitis treatment applications.
Campos, E.V.R. and Proença, P.L.F. and Costa, T.G.d. and de Lima, R. and Hedtrich, S. and Fraceto, L.F. and de Araujo, D.R.
ACS Applied Polymer Materials 3 (9): 4436-4449. 10 September 2021

Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts.
Cantow, K. and Evans, R.G. and Grosenick, D. and Gladytz, T. and Niendorf, T. and Flemming, B. and Seeliger, E.
Methods in Molecular Biology 2216 : 89-107. 2021

Monitoring renal hemodynamics and oxygenation by invasive probes: experimental protocol.
Cantow, K. and Ladwig-Wiegard, M. and Flemming, B. and Pohlmann, A. and Niendorf, T. and Seeliger, E.
Methods in Molecular Biology 2216 : 327-347. 2021

Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.
Cappelletti, V. and Hauser, T. and Piazza, I. and Pepelnjak, M. and Malinovska, L. and Fuhrer, T. and Li, Y. and Dörig, C. and Boersema, P. and Gillet, L. and Grossbach, J. and Dugourd, A. and Saez-Rodriguez, J. and Beyer, A. and Zamboni, N. and Caflisch, A. and de Souza, N. and Picotti, P.
Cell 184 (2): 545-559. 21 January 2021

Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.
Carley, L.N. and Mojica, J.P. and Wang, B. and Chen, C.Y. and Lin, Y.P. and Prasad, K.V.S.K and Chan, E. and Hsu, C.W. and Keith, R. and Nuñez, C.L. and Olson-Manning, C.F. and Rushworth, C.A. and Wagner, M.R. and Wang, J. and Yeh, P.M. and Reichelt, M. and Ghattas, K. and Gershenzon, J. and Lee, C.R. and Mitchell-Olds, T.
Nature Ecology & Evolution 5 : 1135–1144. August 2021

Regulating T-cell differentiation through the polyamine spermidine.
Carriche, G.M. and Almeida, L. and Stüve, P. and Velasquez, L. and Dhillon-LaBrooy, A. and Roy, U. and Lindenberg, M. and Strowig, T. and Plaza-Sirvent, C. and Schmitz, I. and Lochner, M. and Simon, A.K. and Sparwasser, T.
Journal of Allergy and Clinical Immunology 147 (1): 335-348. January 2021

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer.
Carter, D.M. and Specker, E. and Malecki, P.H. and Przygodda, J. and Dudaniec, K. and Weiss, M.S. and Heinemann, U. and Nazaré, M. and Gohlke, U.
Journal of Medicinal Chemistry 64 (19): 14266-14282. 14 October 2021

Heterogeneity of diabetes: β-cells, phenotypes, and precision medicine: proceedings of an international symposium of the canadian institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases.
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Canadian Journal of Diabetes 45 (8): 697-713. December 2021

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Cereghetti, G. and Wilson-Zbinden, C. and Kissling, V.M. and Diether, M. and Arm, A. and Yoo, H. and Piazza, I. and Saad, S. and Picotti, P. and Drummond, D.A. and Sauer, U. and Dechant, R. and Peter, M.
Nature Cell Biology 23 (10): 1085-1094. October 2021

Functional characterization of ovine dorsal root ganglion neurons reveal peripheral sensitization after osteochondral defect.
Chakrabarti, S. and Ai, M. and Wong, K. and Newell, K. and Henson, F.M.D. and Smith, E.S.J.
eNeuro 8 (5): ENEURO.0237-21.2021. September 2021

Design and testing of efficient mucus-penetrating nanogels-pitfalls of preclinical testing and lessons learned.
Charbaji, R. and Kar, M. and Theune, L.E. and Bergueiro, J. and Eichhorst, A. and Navarro, L. and Graff, P. and Stumpff, F. and Calderón, M. and Hedtrich, S.
Small 17 (23): e2007963. 10 June 2021

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Chatzidoukaki, O. and Stratigi, K. and Goulielmaki, E. and Niotis, G. and Akalestou-Clocher, A. and Gkirtzimanaki, K. and Zafeiropoulos, A. and Altmüller, J. and Topalis, P. and Garinis, G.A.
Science Advances 7 (47): eabj5769. 19 November 2021

Transformation of SOX9(+) cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.
Chen, J. and Debebe, A. and Zeng, N. and Kopp, J. and He, L. and Sander, M. and Stiles, B.L.
Scientific Reports 11 (1): 11823. 3 June 2021

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics.
Chiou, J. and Geusz, R.J. and Okino, M.L. and Han, J.Y. and Miller, M. and Melton, R. and Beebe, E. and Benaglio, P. and Huang, S. and Korgaonkar, K. and Heller, S. and Kleger, A. and Preissl, S. and Gorkin, D.U. and Sander, M. and Gaulton, K.J.
Nature 594 (7863): 398-402. 17 June 2021

Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Chiou, J. and Zeng, C. and Cheng, Z. and Han, J.Y. and Schlichting, M. and Miller, M. and Mendez, R. and Huang, S. and Wang, J. and Sui, Y. and Deogaygay, A. and Okino, M.L. and Qiu, Y. and Sun, Y. and Kudtarkar, P. and Fang, R. and Preissl, S. and Sander, M. and Gorkin, D.U. and Gaulton, K.J.
Nature Genetics 53 (4): 455-466. April 2021

FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua, J.Y. and Ng, S.J. and Yagensky, O. and Wanker, E.E. and Chua, J.J.E.
eNeuro 8 (2): ENEURO.0193-20.2021. 26 March 2021

Quantitative analysis of renal perfusion by arterial spin labeling.
Chuang, K.H. and Kober, F. and Ku, M.C.
Methods in Molecular Biology 2216 : 655-666. 2021

Renal blood flow using arterial spin labeling (ASL) MRI: experimental protocol and principles.
Chuang, K.H. and Meier, M. and Fernández-Seara, M.A. and Kober, F. and Ku, M.C.
Methods in Molecular Biology 2216 : 443-453. 2021

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules.
Cipriani, P.G. and Bay, O. and Zinno, J. and Gutwein, M. and Gan, H.H. and Mayya, V.K. and Chung, G. and Chen, J.X. and Fahs, H. and Guan, Y. and Duchaine, T.F. and Selbach, M. and Piano, F. and Gunsalus, K.C.
eLife 10 : e60833. 3 August 2021

Dynamic and equilibrium properties of finite-size polymer models of chromosome folding.
Conte, M. and Fiorillo, L. and Annunziatella, C. and Esposito, A. and Musella, F. and Abraham, A. and Bianco, S. and Chiariello, A.M.
Physical Review E 104 (5): 054402. 10 November 2021

Assessing attacks and treatment response rates among adult patients with NMOSD and MOGAD: data from a nationwide registry in Argentina.
Contentti, E.C. and Lopez, P.A. and Pettinicchi, J.P. and Criniti, J. and Pappolla, A. and Miguez, J. and Patrucco, L. and Carnero Contentti, E. and Liwacki, S. and Tkachuk, V. and Balbuena, M.E. and Vrech, C. and Deri, N. and Correale, J. and Marrodan, M. and Ysrraelit, M.C. and Leguizamon, F. and Luetic, G. and Menichini, M.L. and Tavolini, D. and Mainella, C. and Zanga, G. and Burgos, M. and Hryb, J. and Barboza, A. and Lazaro, L. and Alonso, R. and Liguori, N.F. and Nadur, D. and Chercoff, A. and Alonso Serena, M. and Caride, A. and Paul, F. and Rojas, J.I.
Multiple Sclerosis Journal Experimental Translational and Clinical 7 (3): 20552173211032334. 1 July 2021

Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.
Cooper, G. and Chien, C. and Zimmermann, H. and Bellmann-Strobl, J. and Ruprecht, K. and Kuchling, J. and Asseyer, S. and Brandt, A.U. and Scheel, M. and Finke, C. and Paul, F.
Multiple Sclerosis Journal 27 (14): 2180-2190. December 2021

From forensics to clinical research: expanding the variant calling pipeline for the precision ID mtDNA whole genome panel.
Cortes-Figueiredo, F. and Carvalho, F.S. and Fonseca, A.C. and Paul, F. and Ferro, J.M. and Schönherr, S. and Weissensteiner, H. and Morais, V.A.
International Journal of Molecular Sciences 22 (21): 12031. 6 November 2021

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
Cossarizza, A. and Chang, H.D. and Radbruch, A. and Abrignani, S. and Addo, R. and Akdis, M. and Andrä, I. and Andreata, F. and Annunziato, F. and Arranz, E. and Bacher, P. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Baumjohann, D. and Beccaria, C.G. and Bernardo, D. and Boardman, D.A. and Borger, J. and Böttcher, C. and Brockmann, L. and Burns, M. and Busch, D.H. and Cameron, G. and Cammarata, I. and Cassotta, A. and Chang, Y. and Chirdo, F.G. and Christakou, E. and Čičin-Šain, L. and Cook, L. and Corbett, A.J. and Cornelis, R. and Cosmi, L. and Davey, M.S. and De Biasi, S. and De Simone, G. and Del Zotto, G. and Delacher, M. and Di Rosa, F. and Santo, J.D. and Diefenbach, A. and Dong, J. and Dörner, T. and Dress, R.J. and Dutertre, C.A. and Eckle, S.B.G. and Eede, P. and Evrard, M. and Falk, C.S. and Feuerer, M. and Fillatreau, S. and Fiz-Lopez, A. and Follo, M. and Foulds, G.A. and Fröbel, J. and Gagliani, N. and Galletti, G. and Gangaev, A. and Garbi, N. and Garrote, J.A. and Geginat, J. and Gherardin, N.A. and Gibellini, L. and Ginhoux, F. and Godfrey, D.I. and Gruarin, P. and Haftmann, C. and Hansmann, L. and Harpur, C.M. and Hayday, A.C. and Heine, G. and Hernández, D.C. and Herrmann, M. and Hoelsken, O. and Huang, Q. and Huber, S. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hwang, W.Y.K. and Iannacone, M. and Ivison, S.M. and Jäck, H.M. and Jani, P.K. and Keller, B. and Kessler, N. and Ketelaars, S. and Knop, L. and Knopf, J. and Koay, H.F. and Kobow, K. and Kriegsmann, K. and Kristyanto, H. and Krueger, A. and Kuehne, J.F. and Kunze-Schumacher, H. and Kvistborg, P. and Kwok, I. and Latorre, D. and Lenz, D. and Levings, M.K. and Lino, A.C. and Liotta, F. and Long, H.M. and Lugli, E. and MacDonald, K.N. and Maggi, L. and Maini, M.K. and Mair, F. and Manta, C. and Manz, R.S. and Mashreghi, M.F. and Mazzoni, A. and McCluskey, J. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Monin, L. and Moretta, L. and Multhoff, G. and Muñoz, L.E. and Muñoz-Ruiz, M. and Muscate, F. and Natalini, A. and Neumann, K. and Ng, L.G. and Niedobitek, A. and Niemz, J. and Almeida, L.N. and Notarbartolo, S. and Ostendorf, L. and Pallett, L.J. and Patel, A.A. and Percin, G.I. and Peruzzi, G. and Pinti, M. and Pockley, A.G. and Pracht, K. and Prinz, I. and Pujol-Autonell, I. and Pulvirenti, N. and Quatrini, L. and Quinn, K.M. and Radbruch, H. and Rhys, H. and Rodrigo, M.B. and Romagnani, C. and Saggau, C. and Sakaguchi, S. and Sallusto, F. and Sanderink, L. and Sandrock, I. and Schauer, C. and Scheffold, A. and Scherer, H.U. and Schiemann, M. and Schildberg, F.A. and Schober, K. and Schoen, J. and Schuh, W. and Schüler, T. and Schulz, A.R. and Schulz, S. and Schulze, J. and Simonetti, S. and Singh, J. and Sitnik, K.M. and Stark, R. and Starossom, S. and Stehle, C. and Szelinski, F. and Tan, L. and Tarnok, A. and Tornack, J. and Tree, T.I.M. and van Beek, J.J.P. and van de Veen, W. and van Gisbergen, K. and Vasco, C. and Verheyden, N.A. and von Borstel, A. and Ward-Hartstonge, K.A. and Warnatz, K. and Waskow, C. and Wiedemann, A. and Wilharm, A. and Wing, J. and Wirz, O. and Wittner, J. and Yang, J.H.M. and Yang, J.
European Journal of Immunology 51 (12): 2708-3145. December 2021

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A. and Haage, V. and Yang, S. and Wegner, S. and Ersoy, B. and Ugursu, B. and Rex, A. and Kronenberg, G. and Gertz, K. and Endres, M. and Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91 : 89-104. January 2021

Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD.
Cree, B.A.C. and Bennett, J.L. and Kim, H.J. and Weinshenker, B.G. and Pittock, S.J. and Wingerchuk, D. and Fujihara, K. and Paul, F. and Cutter, G.R. and Marignier, R. and Green, A.J. and Aktas, O. and Hartung, H.P. and Williams, I.M. and Drappa, J. and She, D. and Cimbora, D. and Rees, W. and Ratchford, J.N. and Katz, E.
Multiple Sclerosis Journal 27 (13): 2052-2061. 1 November 2021

Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis.
Cruz-Herranz, A. and Oertel, F.C. and Kim, K. and Cantó, E. and Timmons, G. and Sin, J.H. and Devereux, M. and Baker, N. and Michel, B. and Schubert, R.D. and Rani, L. and Cordano, C. and Baranzini, S.E. and Green, A.J.
JCI Insight 6 (11): e149228. 8 June 2021

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
Cuello, F. and Knaust, A.E. and Saleem, U. and Loos, M. and Raabe, J. and Mosqueira, D. and Laufer, S. and Schweizer, M. and Kraak, P. and Flenner, F. and Ulmer, B.M and Braren, I. and Yin, X. and Theofilatos, K. and Ruiz-Orera, J. and Patone, G. and Klampe, B. and Schulze, T. and Piasecki, A. and Pinto, Y. and Vink, A. and Hübner, N. and Harding, S. and Mayr, M. and Denning, C. and Eschenhagen, T. and Hansen, A.
EMBO Molecular Medicine 13 (6): e13074. 7 June 2021

Reduction of tissue Na(+) accumulation after renal transplantation.
Dahlmann, A. and Linz, P. and Zucker, I. and Haag, V. and Jantsch, J. and Dienemann, T. and Nagel, A.M. and Neubert, P. and Rosenhauer, D. and Rauh, M. and Horn, S. and Müller, D.N. and Schiffer, M. and Luft, F.C. and Uder, M. and Kopp, C.
Kidney International Reports 6 (9): 2338-2347. September 2021

Combination of Wnt/β-catenin targets S100A4 and DKK1 improves prognosis of human colorectal cancer.
Dahlmann, M. and Monks, A. and Harris, E.D. and Kobelt, D. and Osterland, M. and Khaireddine, F. and Herrmann, P. and Kemmner, W. and Burock, S. and Walther, W. and Shoemaker, R.H. and Stein, U.
Cancers 14 (1): 37. 22 December 2021

A bioinformatic pipeline to identify biomarkers for metastasis formation from RNA sequencing data.
Dahlmann, M. and Stein, U.S.
Methods in Molecular Biology 2294 : 221-238. 2021

Early bilirubinemia after allogeneic stem cell transplantation - an endothelial complication.
Dai, H. and Penack, O. and Radujkovic, A. and Schult, D. and Majer-Lauterbach, J. and Blau, I.W. and Bullinger, L. and Jiang, S. and Müller-Tidow, C. and Dreger, P. and Luft, T.
Bone Marrow Transplantation 56 (7): 1573-1583. July 2021

Clinical and genetic characterization of PYROXD1-related myopathy patients from Turkey.
Daimagüler, H.S. and Akpulat, U. and Özdemir, Ö. and Yis, U. and Güngör, S. and Talim, B. and Diniz, G. and Baydan, F. and Thiele, H. and Altmüller, J. and Nürnberg, P. and Cirak, S.
American Journal of Medical Genetics A 185 (6): 1678-1690. 14 May 2021

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. and Lebedin, M. and de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021

Thyrotropin receptor-specific lymphocytes in adenovirus-TSHR-immunized native and human leukocyte antigen-DR3-transgenic mice and in Graves' disease patient blood.
Degen, H. and Gavvovidis, I. and Blankenstein, T. and Uhland, K. and Ungerer, M.
Thyroid 31 (6): 950-963. June 2021

Hardware considerations for preclinical magnetic resonance of the kidney.
Delgado, P.R. and Küstermann, E. and Kühne, A. and Millward, J.M. and Niendorf, T. and Pohlmann, A. and Meier, M.
Methods in Molecular Biology 2216 : 131-155. 2021

A medullary centre for lapping in mice.
Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
Nature Communications 12 : 6307. 2 November 2021

Elevated Flt3L predicts long-term survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.
Detjen, K.M. and Otto, R. and Giesecke, Y. and Geisler, L. and Riemer, P. and Jann, H. and Grötzinger, C. and Sers, C. and Pascher, A. and Lüdde, T. and Leser, U. and Wiedenmann, B. and Sigal, M. and Tacke, F. and Roderburg, C. and Hammerich, L.
Cancers 13 (17): 4463. 1 September 2021

„Liquid biopsies“ als neue Diagnostikplattform in der pädiatrischen Onkologie [Liquid biopsies as a new diagnostic platform in pediatric oncology].
Deubzer, H.E. and Eggert, A. and Pajtler, K. W.
Onkologe 27 (5): 458-463. May 2021

An agenda-setting paper on data sharing platforms: euCanSHare workshop.
Devriendt, T. and Ammann, C. and Asselbergs, F.W. and Bernier, A. and Costas, R. and Friedrich, M.G. and Gelpi, J.L. and Jarvelin, M.R. and Kuulasmaa, K. and Lekadir, K. and Mayrhofer, M.T. and Papez, V. and Pasterkamp, G. and Petersen, S.E. and Schmidt, C.O. and Schulz-Menger, J. and Söderberg, S. and Shabani, M. and Veronesi, G. and Viezzer, D.S. and Borry, P.
Open Research Europe 1 : 80. 23 November 2021

From tube to structure: SPA Cryo-EM workflow using apoferritin as an example.
Diebolder, C.A. and Dillard, R.S. and Renault, L.
Methods in Molecular Biology 2305 (2305): 229-256. 6 May 2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener, J. and Baggiolini, A. and Pernebrink, M. and Dalcher, D. and Lerra, L. and Cheng, P.F. and Varum, S. and Häusel, J. and Stierli, S. and Treier, M. and Studer, L. and Basler, K. and Levesque, M.P. and Dummer, R. and Santoro, R. and Cantù, C. and Sommer, L.
Nature Communications 12 (1): 5056. 20 August 2021

Structure of the merozoite surface protein 1 from Plasmodium falciparum.
Dijkman, P.M. and Marzluf, T. and Zhang, Y. and Chang, S.Y.S. and Helm, D. and Lanzer, M. and Bujard, H. and Kudryashev, M.
Science Advances 7 (23): eabg0465. June 2021

COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab.
Dimai, S. and Semmler, L. and Prabhu, A. and Stachelscheid, H. and Huettemeister, J. and Klaucke, S.C. and Lacour, P. and Blaschke, F. and Kruse, J. and Parwani, A. and Boldt, L.H. and Bullinger, L. and Pieske, B.M. and Heinzel, F.R. and Hohendanner, F.
PLoS ONE 16 (8): e0255976. 19 August 2021

Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data.
Dimchev, G. and Amiri, B. and Fäßler, F. and Falcke, M. and Schur, F.K.M.
Journal of Structural Biology 213 (4): 107808. December 2021

Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa.
Dommisch, H. and Stolte, K.N. and Jager, J. and Vogel, K. and Müller, R. and Hedtrich, S. and Unbehauen, M. and Haag, R. and Danker, K.
Clinical Oral Investigations 25 (10): 5795-5805. October 2021

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M. and Klinger, B. and Mari, T. and Toedling, J. and Blanc, E. and Messerschmidt, C. and Nadler-Holly, M. and Ziehm, M. and Sieber, A. and Hertwig, F. and Beule, D. and Eggert, A. and Schulte, J.H. and Selbach, M. and Blüthgen, N.
PLoS Computational Biology 17 (11): e1009515. 4 November 2021

Modeling Structure-Activity Relationship of AMPK Activation.
Drewe, J. and Küsters, E. and Hammann, F. and Kreuter, M. and Boss, P. and Schöning, V.
Molecules 26 (21): 6508. 1 November 2021

Satralizumab in the treatment of neuromyelitis optica spectrum disorder.
Duchow, A. and Bellmann-Strobl, J.
Neurodegenerative Disease Management 11 (1): 49-59. February 2021

Generation of Epstein-Barr virus antigen-specific T cell receptors recognizing immunodominant epitopes of LMP1, LMP2A, and EBNA3C for immunotherapy.
Dudaniec, K. and Westendorf, K. and Nössner, E. and Uckert, W.
Human Gene Therapy 32 (17-18): 919-935. 21 September 2021

Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Duncan, A.R. and Polovitskaya, M.M. and Gaitán-Peñas, H. and Bertelli, S. and VanNoy, G.E. and Grant, P.E. and O'Donnell-Luria, A. and Valivullah, Z. and Lovgren, A.K. and England, E.M. and Agolini, E. and Madden, J.A. and Schmitz-Abe, K. and Kritzer, A. and Hawley, P. and Novelli, A. and Alfieri, P. and Colafati, G.S. and Wieczorek, D. and Platzer, K. and Luppe, J. and Koch-Hogrebe, M. and Abou Jamra, R. and Neira-Fresneda, J. and Lehman, A. and Boerkoel, C.F. and Seath, K. and Clarke, L. and van Ierland, Y. and Argilli, E. and Sherr, E.H. and Maiorana, A. and Diel, T. and Hempel, M. and Bierhals, T. and Estévez, R. and Jentsch, T.J. and Pusch, M. and Agrawal, P.B.
American Journal of Human Genetics 108 (8): 1450-1465. 5 August 2021

Evaluation of aggression and fearfulness in domestic dog (Canis familiaris).
Dyjak, M. and Boruta, A. and Adamkiewicz, E. and Walasek, A. and Bury-Burzymski, P. and Lisowski, P.
Animal Science Papers and Reports 39 (4): 407-418. 2021

Long-term follow-up after the application of mesenchymal stromal cells in children and adolescents with steroid-refractory graft-versus-host disease.
Döring, M. and Cabanillas Stanchi, K.M. and Lenglinger, K. and Treuner, C. and Gieseke, F. and Erbacher, A. and Mezger, M. and Vaegler, M. and Schlegel, P.G. and Greil, J. and Bettoni da Cunha Riehm, C. and Faul, C. and Schumm, M. and Lang, P. and Handgretinger, R. and Müller, I.
Stem Cells and Development 30 (5): 234-246. 19 February 2021

Germline mutations including the rare pathogenic variant c.3206delC in the ATM gene cause ataxia teleangiectasia-associated primary central nervous system lymphoma.
Dörr, J.R. and Thorwarth, A. and Mizia-Malarz, A. and Radke, J. and Tietze, A. and Hernáiz-Driever, P. and Horn, D. and Gratopp, A. and Eggert, A. and Deubzer, H.E.
Children 8 (6): 469. June 2021

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Ebert, P. and Audano, P. A. and Zhu, Q. and Rodriguez-Martin, B. and Porubsky, D. and Bonder, M.J. and Sulovari, A. and Ebler, J. and Zhou, W. and Serra Mari, R. and Yilmaz, F. and Zhao, X. and Hsieh, P.H. and Lee, J. and Kumar, S. and Lin, J. and Rausch, T. and Chen, Y. and Ren, J. and Santamarina, M. and Höps, W. and Ashraf, H. and Chuang, N.T. and Yang, X. and Munson, K.M. and Lewis, A.P. and Fairley, S. and Tallon, L.J. and Clarke, W.E. and Basile, A.O. and Byrska-Bishop, M. and Corvelo, A. and Evani, U.S. and Lu, T.Y. and Chaisson, M.J.P. and Chen, J. and Li, C. and Brand, H. and Wenger, A.M. and Ghareghani, M. and Harvey, W.T. and Raeder, B. and Hasenfeld, P. and Regier, A.A. and Abel, H.J. and Hall, I.M. and Flicek, P. and Stegle, O. and Gerstein, M.B and Tubio, J.M.C. and Mu, Z. and Li, Y.I. and Shi, X. and Hastie, A.R. and Ye, K. and Chong, Z. and Sanders, A.D. and Zody, M.C. and Talkowski, M.E. and Mills, R. E. and Devine, S.E. and Lee, C. and Korbel, J.O. and Marschall, T. and Eichler, E.E.
Science 372 (6537): eabf7117. 25 February 2021

A helminth-derived chitinase structurally similar to mammalian chitinase displays immunomodulatory properties in inflammatory lung disease.
Ebner, F. and Lindner, K. and Janek, K. and Niewienda, A. and Malecki, P.H. and Weiss, M.S. and Sutherland, T.E. and Heuser, A. and Kühl, A.A. and Zentek, J. and Hofmann, A. and Hartmann, S.
Journal of Immunology Research 2021 : 234836. 25 November 2021

Cystatin M/E variant causes autosomal dominant keratosis follicularis spinulosa decalvans by dysregulating cathepsins L and V.
Eckl, K.M. and Gruber, R. and Brennan, L. and Marriott, A. and Plank, R. and Moosbrugger-Martinz, V. and Blunder, S. and Schossig, A. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Zschocke, J. and Hennies, H.C. and Schmuth, M.
Frontiers in Genetics 12 : 689940. July 2021

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling.
Edgar, L.T. and Franco, C.A. and Gerhardt, H. and Bernabeu, M.O.
PLoS Computational Biology 17 (2): e1007715. 4 February 2021

Surface AMP deaminase 2 as a novel regulator modifying extracellular adenine nucleotide metabolism.
Ehlers, L. and Kuppe, A. and Damerau, A. and Wilantri, S. and Kirchner, M. and Mertins, P. and Strehl, C. and Buttgereit, F. and Gaber, T.
FASEB Journal 35 (7): e21684. July 2021

32-channel self-grounded bow-tie transceiver array for cardiac MR at 7.0T.
Eigentler, T.W. and Kuehne, A. and Boehmert, L. and Dietrich, S. and Els, A. and Waiczies, H. and Niendorf, T.
Magnetic Resonance in Medicine 86 (5): 2862-2879. November 2021

ASHLEYS: automated quality control for single-cell Strand-seq data.
Eimer, C. and Sanders, A.D. and Korbel, J.O. and Marschall, T. and Ebert, P.
Bioinformatics 37 (19): 3356-3357. 1 October 2021

Patch individual filter layers in CNNs to harness the spatial homogeneity of neuroimaging data.
Eitel, F. and Albrecht, J.P. and Weygandt, M. and Paul, F. and Ritter, K.
Scientific Reports 11 (1): 24447. 27 December 2021

Homozygous nonsense mutation of WTN10B gene in a Moroccan family with split-hand foot malformation identified by exome sequencing: a case report.
Elalaoui, S.C. and Fejjal, N. and Li, Y. and Thiele, H. and Altmüller, J. and Guaoua, S. and Nürnberg, P. and Wollnik, B. and Sefiani, A. and Ratbi, I.
Pan African Medical Journal 39 : 21. May 2021

Improving target assessment in biomedical research: the GOT-IT recommendations.
Emmerich, C.H. and Gamboa, L.M. and Hofmann, M.C.J. and Bonin-Andresen, M. and Arbach, O. and Schendel, P. and Gerlach, B. and Hempel, K. and Bespalov, A. and Dirnagl, U. and Parnham, M.J.
Nature Reviews Drug Discovery 20 (1): 64-81. January 2021

Complex population dynamics in a spatial microbial ecosystem with Physarum polycephalum.
Epstein, L. and Dubois, Z. and Smith, J. and Lee, Y. and Harrington, K.
Biosystems 208 : 104483. October 2021

Transposable elements and introgression introduce genetic variation in the invasive ant Cardiocondyla obscurior.
Errbii, M. and Keilwagen, J. and Hoff, K.J. and Steffen, R. and Altmüller, J. and Oettler, J. and Schrader, L.
Molecular Ecology 30 (23): 6211-6228. December 2021

Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, C. and Galea, E. and Lakatos, A. and O'Callaghan, J.P. and Petzold, G.C. and Serrano-Pozo, A. and Steinhäuser, C. and Volterra, A. and Carmignoto, G. and Agarwal, A. and Allen, N.J. and Araque, A. and Barbeito, L. and Barzilai, A. and Bergles, D.E. and Bonvento, G. and Butt, A.M. and Chen, W.T. and Cohen-Salmon, M. and Cunningham, C. and Deneen, B. and De Strooper, B. and Díaz-Castro, B. and Farina, C. and Freeman, M. and Gallo, V. and Goldman, J.E. and Goldman, S.A. and Götz, M. and Gutiérrez, A. and Haydon, P.G. and Heiland, D.H. and Hol, E.M. and Holt, M.G. and Iino, M. and Kastanenka, K.V. and Kettenmann, H. and Khakh, B.S. and Koizumi, S. and Lee, C.J. and Liddelow, S.A. and MacVicar, B.A. and Magistretti, P. and Messing, A. and Mishra, A. and Molofsky, A.V. and Murai, K.K. and Norris, C.M. and Okada, S. and Oliet, S.H.R. and Oliveira, J.F. and Panatier, A. and Parpura, V. and Pekna, M. and Pekny, M. and Pellerin, L. and Perea, G. and Pérez-Nievas, B.G. and Pfrieger, F.W. and Poskanzer, K.E. and Quintana, F.J. and Ransohoff, R.M. and Riquelme-Perez, M. and Robel, S. and Rose, C.R. and Rothstein, J.D. and Rouach, N. and Rowitch, D.H. and Semyanov, A. and Sirko, S. and Sontheimer, H. and Swanson, R.A. and Vitorica, J. and Wanner, I.B. and Wood, L.B. and Wu, J. and Zheng, B. and Zimmer, E.R. and Zorec, R. and Sofroniew, M.V. and Verkhratsky, A.
Nature Neuroscience 24 (3): 312-325. March 2021

Base editing repairs an SGCA mutation in human primary muscle stem cells.
Escobar, H. and Krause, A. and Keiper, S. and Kieshauer, J. and Müthel, S. and García de Paredes, M. and Metzler, E. and Kühn, R. and Heyd, F. and Spuler, S.
JCI Insight 6 (10): e145994. 24 May 2021

Expanding the spectrum of FAT1 nephropathies by novel mutations that affect hippo signaling.
Fabretti, F. and Tschernoster, N. and Erger, F. and Hedergott, A. and Buescher, A.K. and Dafinger, C. and Reusch, B. and Köntges, V.K. and Kohl, S. and Bartram, M.P. and Weber, L.T. and Thiele, H. and Altmueller, J. and Schermer, B. and Beck, B.B. and Habbig, S.
Kidney International Reports 6 (5): 1368-1378. May 2021

Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi, Z. and Walde, M. and Klementowicz, A.E. and Paraskevopoulou, F. and Woehler, A.
iScience 24 (1): 101909. 22 January 2021

Galectin-levels are elevated in infants born preterm due to amniotic infection and rapidly decline in the neonatal period.
Faust, K. and Freitag, N. and Barrientos, G. and Hartel, C. and Blois, S.M.
Frontiers in Immunology 11 : 599104. 25 February 2021

Contribution of IQ in young adulthood to the associations of education and occupation with cognitive ability in older age.
Feinkohl, I. and Kozma, P. and Borchers, F. and van Montfort, S.J.T. and Kruppa, J. and Winterer, G. and Spies, C. and Pischon, T.
BMC Geriatrics 21 (1): 346. 5 June 2021

MTBP phosphorylation controls DNA replication origin firing.
Ferreira, P. and Höfer, V. and Kronshage, N. and Marko, A. and Reusswig, K.U. and Tetik, B. and Dießel, C. and Köhler, K. and Tschernoster, N. and Altmüller, J. and Schulze, N. and Pfander, B. and Boos, D.
Scientific Reports 11 (1): 4242. 19 February 2021

The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
Figueiredo, M. and Daryadel, A. and Sihn, G. and Müller, D.N. and Popova, E. and Rouselle, A. and Nguyen, G. and Bader, M. and Wagner, C.A.
Pflugers Archiv 473 : 1229-1246. August 2021

Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin.
Fiorillo, L. and Musella, F. and Conte, M. and Kempfer, R. and Chiariello, A.M. and Bianco, S. and Kukalev, A. and Irastorza-Azcarate, I. and Esposito, A. and Abraham, A. and Prisco, A. and Pombo, A. and Nicodemi, M.
Nature Methods 18 (5): 482-490. May 2021

NFDI4Health - Nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten.
Fluck, J. and Lindstädt, B. and Ahrens, W. and Beyan, O. and Buchner, B. and Darms, J. and Depping, R. and Dierkes, J. and Fröhlich, H. and Gehrke, J. and Golebiewski, M. and Grabenhenrich, L. and Hahn, H.K. and Kirsten, T. and Klammt, S. and Kusch, H. and Löbe, M. and Löffler, M. and Meineke, F. and Müller, W. and Neuhausen, H. and Nöthlings, U. and Pischon, T. and Prasser, F. and Sax, U. and Schmidt, C.O. and Schulze, M. and Semler, S.C. and Thun, S. and Waltemath, D. and Wieler, L.H. and Zeeb, H. and Pigeot, I.
Bausteine Forschungsdatenmanagement 2021 (2): 72-85. 28 July 2021

An autochthonous mouse model of Myd88- and BCL2-driven diffuse large B-cell lymphoma reveals actionable molecular vulnerabilities.
Flümann, R. and Rehkämper, T. and Nieper, P. and Pfeiffer, P. and Holzem, A. and Klein, S. and Bhatia, S. and Kochanek, M. and Kisis, I. and Pelzer, B.W. and Ahlert, H. and Hauer, J. and da Palma Guerreiro, A. and Ryan, J.A. and Reimann, M. and Riabinska, A. and Wiederstein, J. and Krüger, M. and Deckert, M. and Altmüller, J. and Klatt, A.R. and Frenzel, L.P. and Pasqualucci, L. and Béguelin, W. and Melnick, A.M. and Sander, S. and Montesinos-Rongen, M. and Brunn, A. and Lohneis, P. and Büttner, R. and Kashkar, H. and Borkhardt, A. and Letai, A. and Persigehl, T. and Peifer, M. and Schmitt, C.A. and Reinhardt, H.C. and Knittel, G.
Blood Cancer Discovery 2 (1): 70-91. January 2021

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A. and Gärtner, A. and Cyganek, L. and Tiburcy, M. and Tuleta, I. and Wellers, L. and Folsche, L. and Hobbach, A.J. and von Frieling-Salewsky, M. and Unger, A. and Hucke, A. and Koser, F. and Kassner, A. and Sielemann, K. and Streckfuß-Bömeke, K. and Hasenfuss, G. and Goedel, A. and Laugwitz, K.L. and Moretti, A. and Gummert, J.F. and Dos Remedios, C.G. and Reinecke, H. and Knöll, R. and van Heesch, S. and Hubner, N. and Zimmermann, W.H. and Milting, H. and Linke, W.A.
Science Translational Medicine 13 (618): eabd3079. 3 November 2021

The SEQC2 epigenomics quality control (EpiQC) study.
Foox, J. and Nordlund, J. and Lalancette, C. and Gong, T. and Lacey, M. and Lent, S. and Langhorst, B.W. and Ponnaluri, V.K.C. and Williams, L. and Padmanabhan, K.R. and Cavalcante, R. and Lundmark, A. and Butler, D. and Mozsary, C. and Gurvitch, J. and Greally, J.M. and Suzuki, M. and Menor, M. and Nasu, M. and Alonso, A. and Sheridan, C. and Scherer, A. and Bruinsma, S. and Golda, G. and Muszynska, A. and Łabaj, P.P. and Campbell, M.A. and Wos, F. and Raine, A. and Liljedahl, U. and Axelsson, T. and Wang, C. and Chen, Z. and Yang, Z. and Li, J. and Yang, X. and Wang, H. and Melnick, A. and Guo, S. and Blume, A. and Franke, V. and Ibanez de Caceres, I. and Rodriguez-Antolin, C. and Rosas, R. and Davis, J.W. and Ishii, J. and Megherbi, D.B. and Xiao, W. and Liao, W. and Xu, J. and Hong, H. and Ning, B. and Tong, W. and Akalin, A. and Wang, Y. and Deng, Y. and Mason, C.E.
Genome Biology 22 (1): 332. 6 December 2021

Combinatorial, additive and dose-dependent drug-microbiome associations.
Forslund, S.K. and Chakaroun, R. and Zimmermann-Kogadeeva, M. and Markó, L. and Aron-Wisnewsky, J. and Nielsen, T. and Moitinho-Silva, L. and Schmidt, T.S.B. and Falony, G. and Vieira-Silva, S. and Adriouch, S. and Alves, R.J. and Assmann, K. and Bastard, J.P. and Birkner, T. and Caesar, R. and Chilloux, J. and Coelho, L.P. and Fezeu, L. and Galleron, N. and Helft, G. and Isnard, R. and Ji, B. and Kuhn, M. and Le Chatelier, E. and Myridakis, A. and Olsson, L. and Pons, N. and Prifti, E. and Quinquis, B. and Roume, H. and Salem, J.E. and Sokolovska, N. and Tremaroli, V. and Valles-Colomer, M. and Lewinter, C. and Søndertoft, N.B. and Pedersen, H.K. and Hansen, T.H. and Gøtze, J.P. and Køber, L. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Hercberg, S. and Oppert, J.M. and Letunic, I. and Nielsen, J. and Bäckhed, F. and Ehrlich, S.D. and Dumas, M.E. and Raes, J. and Pedersen, O. and Clément, K. and Stumvoll, M. and Bork, P.
Nature 600 : 500-505. 16 December 2021

Characteristics of secondary progressive multiple sclerosis: disease activity and provision of care in Germany - a registry-based/multicentric cohort study.
Frahm, N. and Ellenberger, D. and Fneish, F. and Christoph, K. and Warnke, C. and Zettl, U.K. and Paul, F. and Rauser, B. and Stahmann, A. and Vogelmann, V. and Flachenecker, P.
Multiple Sclerosis and Related Disorders 56 : 103281. November 2021

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
Franke, M. and De la Calle-Mustienes, E. and Neto, A. and Almuedo-Castillo, M. and Irastorza-Azcarate, I. and Acemel, R.D. and Tena, J.J. and Santos-Pereira, J.M. and Gómez-Skarmeta, J.L.
Nature Communications 12 (1): 5415. 13 September 2021

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.
Franken, G.A.C. and Seker, M. and Bos, C. and Siemons, L.A.H. and van der Eerden, B.C.J. and Christ, A. and Hoenderop, J.G.J. and Bindels, R.J.M. and Müller, D. and Breiderhoff, T. and de Baaij, J.H.F.
Scientific Reports 11 (1): 8217. 15 April 2021

Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics.
Franz, A. and Coscia, F. and Shen, C. and Charaoui, L. and Mann, M. and Sander, C.
Journal of Ovarian Research 14 (1): 140. 22 October 2021

Overcoming barriers to the adoption of locating technologies in dementia care: a multi-stakeholder focus group study.
Freiesleben, S.D. and Megges, H. and Herrmann, C. and Wessel, L. and Peters, O.
BMC Geriatrics 21 (1): 378. 21 June 2021

Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models.
Freitag, N. and Xie, Y. and Adam, L.M. and Borowski, S. and Blois, S.M. and Barrientos, G.
American Journal of Reproductive Immunology 86 (6): e13491. December 2021

Dissecting herpes simplex virus 1-induced host shutoff at the RNA level.
Friedel, C.C. and Whisnant, A.W. and Djakovic, L. and Rutkowski, A.J. and Friedl, M.S. and Kluge, M. and Williamson, J.C. and Sai, S. and Vidal, R.O. and Sauer, S. and Hennig, T. and Grothey, A. and Milić, A. and Prusty, B.K. and Lehner, P.J. and Matheson, N.J. and Erhard, F. and Dölken, L.
Journal of Virology 95 (3): e01399-20. 13 January 2021

Stochastic reaction-diffusion modeling of calcium dynamics in 3D-dendritic spines of purkinje cells.
Friedhoff, V.N. and Antunes, G. and Falcke, M. and Simões de Souza, F.M.
Biophysical Journal 120 (11): 2112-2123. 1 June 2021

Models of stochastic Ca(2+) spiking : established approaches and inspirations from models of neuronal spikes.
Friedhoff, V.N. and Ramlow, L. and Lindner, B. and Falcke, M.
European Physical Journal Special Topics 230 (16-17): 2911-2928. October 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C. and Schallenberg, S. and Kirchner, M. and Ziehm, M. and Niquet, S. and Haji, M. and Beier, C. and Neudecker, J. and Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

Resting energy expenditure of master athletes: accuracy of predictive equations and primary determinants.
Frings-Meuthen, P. and Henkel, S. and Boschmann, M. and Chilibeck, P.D. and Alvero Cruz, J.R. and Hoffmann, F. and Möstl, S. and Mittag, U. and Mulder, E. and Rittweger, N. and Sies, W. and Tanaka, H. and Rittweger, J.
Frontiers in Physiology 12 : 641455. 22 March 2021

Optimized workflow for on-line derivatization for targeted metabolomics approach by gas chromatography-mass spectrometry.
Fritsche-Guenther, R. and Gloaguen, Y. and Bauer, A. and Opialla, T. and Kempa, S. and Fleming, C.A. and Redmond, H.P. and Kirwan, J.A.
Metabolites 11 (12): 888. 18 December 2021

Estimation of C. elegans cell- and tissue volumes.
Froehlich, J.J. and Rajewsky, N. and Ewald, C.Y.
microPublication Biology : 000345. 4 January 2021

Parallel genetics of regulatory sequences using scalable genome editing in vivo.
Froehlich, J.J. and Uyar, B. and Herzog, M. and Theil, K. and Glažar, P. and Akalin, A. and Rajewsky, N.
Cell Reports 35 (2): 108988. 13 April 2021

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells.
Fu, R. and Wellman, K. and Baldwin, A. and Rege, J. and Walters, K. and Hirsekorn, A. and Riemondy, K. and Rainey, W.E and Mukherjee, N.
RNA 27 (8): 933-945. August 2021

Use of cement suspension as an alternative matrix material for textile-reinforced concrete.
Fürst, R. and Fürst, E. and Vlach, T. and Řepka, J. and Pokorný, M. and Mózer, V.
Materials 14 (9): 2127. 1 May 2021

Human brain organoids assemble functionally integrated bilateral optic vesicles.
Gabriel, E. and Albanna, W. and Pasquini, Gi. and Ramani, A. and Josipovic, N. and Mariappan, A. and Schinzel, F. and Karch, C.M. and Bao, G. and Gottardo, M. and Suren, A.A. and Hescheler, J. and Nagel-Wolfrum, K. and Persico, V. and Rizzoli, S.O. and Altmüller, J. and Riparbelli, M.G. and Callaini, G. and Goureau, O. and Papantonis, A. and Busskamp, V. and Schneider, T. and Gopalakrishnan, J.
Cell Stem Cell 28 (10): 1740-1757.e8. October 2021

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects.
Galgoczi, S. and Ruzo, A. and Markopoulos, C. and Yoney, A. and Phan-Everson, T. and Li, S. and Haremaki, T. and Metzger, J.J. and Etoc, F. and Brivanlou, A.H.
Development 148 (19): dev199513. October 2021

Challenges in cell transplantation for muscular dystrophy.
Galli, F. and Mouly, V. and Butler-Browne, G. and Cossu, G.
Experimental Cell Research 409 (1): 112908. 1 December 2021

The polygonal cell shape and surface protein layer of anaerobic methane-oxidizing (methylomirabilis lanthanidiphila) bacteria.
Gambelli, L. and Mesman, R. and Versantvoort, W. and Diebolder, C.A. and Engel, A. and Evers, W. and Jetten, M.S.M. and Pabst, M. and Daum, B. and van Niftrik, L.
Frontiers in Microbiology 12 : 766527. 1 December 2021

Landscape of HER2-low metastatic breast cancer (MBC): results from the Austrian AGMT_MBC-Registry.
Gampenrieder, S.P. and Rinnerthaler, G. and Tinchon, C. and Petzer, A. and Balic, M. and Heibl, S. and Schmitt, C. and Zabernigg, A.F. and Egle, D. and Sandholzer, M. and Singer, C.F. and Roitner, F. and Hager, C. and Andel, J. and Hubalek, M. and Knauer, M. and Greil, R.
Breast Cancer Research 23 (1): 112. 14 December 2021

Reduced mitochondrial respiration in T cells of patients with major depressive disorder.
Gamradt, S. and Hasselmann, H. and Taenzer, A. and Brasanac, J. and Stiglbauer, V. and Sattler, A. and Sajitz-Hermstein, M. and Kierszniowska, S. and Ramien, C. and Nowacki, J. and Mascarell-Maricic, L. and Wingenfeld, K. and Piber, D. and Ströhle, A. and Kotsch, K. and Paul, F. and Otte, C. and Gold, S.M.
iScience 24 (11): 103312. 19 November 2021

Intellectual disability associated with craniofacial dysmorphism, cleft palate, and congenital heart defect due to a de novo MEIS2 mutation: a clinical longitudinal study.
Gangfuß, A. and Yigit, G. and Altmüller, J. and Nürnberg, P. and Czeschik, J.C. and Wollnik, B. and Bögershausen, N. and Burfeind, P. and Wieczorek, D. and Kaiser, F. and Roos, A. and Kölbel, H. and Schara-Schmidt, U. and Kuechler, A.
American Journal of Medical Genetics A 185 (4): 1216-1221. April 2021

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M. and Vancraenenbroeck, R. and Rosenblum, G. and Hofmann, H. and Mikhailov, A.S. and Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2101144118. 13 July 2021

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X. and Bender, F. and Soh, H. and Chen, C. and Altafi, M. and Schütze, S. and Heidenreich, M. and Gorbati, M. and Corbu, M.A. and Carus-Cadavieco, M. and Korotkova, T. and Tzingounis, A.V. and Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12 (1): 4801. 10 August 2021

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Garg, A. and Roske, Y. and Yamada, S. and Uehata, T. and Takeuchi, O. and Heinemann, U.
Nucleic Acids Research 49 (9): 5369-5381. 21 May 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C. and Papies, J. and Bajaj, T. and Emanuel, J. and Dethloff, F. and Chua, R.L. and Trimpert, J. and Heinemann, N. and Niemeyer, C. and Weege, F. and Hönzke, K. and Aschman, T. and Heinz, D.E. and Weckmann, K. and Ebert, T. and Zellner, A. and Lennarz, M. and Wyler, E. and Schroeder, S. and Richter, A. and Niemeyer, D. and Hoffmann, K. and Meyer, T.F. and Heppner, F.L. and Corman, V.M. and Landthaler, M. and Hocke, A.C. and Morkel, M. and Osterrieder, N. and Conrad, C. and Eils, R. and Radbruch, H. and Giavalisco, P. and Drosten, C. and Müller, M.A.
Nature Communications 12 (1): 3818. 21 June 2021

Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry.
Ge, Y. and Steel, K. and Antiochos, P. and Bingham, S. and Abdullah, S. and Mikolich, J.R. and Arai, A.E. and Bandettini, W.P. and Shanbhag, S.M. and Patel, A.R. and Farzaneh-Far, A. and Heitner, J.F. and Shenoy, C. and Leung, S.W. and Gonzalez, J.A. and Shah, D.J. and Raman, S.V. and Nawaz, H. and Ferrari, V.A. and Schulz-Menger, J. and Stuber, M. and Simonetti, O.P. and Kwong, R.Y.
European Heart Journal - Cardiovascular Imaging 22 (5): 518-527. May 2021

Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
Gebert, J. and Gelincik, O. and Oezcan-Wahlbrink, M. and Marshall, J.D. and Hernandez-Sanchez, A. and Urban, K. and Long, M. and Cortes, E. and Tosti, E. and Katzenmaier, E.M. and Song, Y. and Elsaadi, A. and Deng, N. and Vilar, E. and Fuchs, V. and Nelius, N. and Yuan, Y.P. and Ahadova, A. and Sei, S. and Shoemaker, R.H. and Umar, A. and Wei, L. and Liu, S. and Bork, P. and Edelmann, W. and von Knebel Doeberitz, M. and Lipkin, S.M. and Kloor, M.
Gastroenterology 161 (4): 288-1302.e13. October 2021

Identifying cell-type-specific metabolic signatures using transcriptome and proteome analyses.
Gebert, N. and Rahman, S. and Lewis, C.A. and Ori, A. and Cheng, C.W.
Current Protocols 1 (9): e245. 28 September 2021

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S. and Bartolomaeus, H. and Neubert, P. and Willebrand, R. and Zasada, C. and Bartolomaeus, T. and McParland, V. and Swinnen, D. and Geuzens, A. and Maifeld, A. and Krampert, L. and Vogl, M. and Mähler, A. and Wilck, N. and Marko, L. and Tilic, E. and Forslund, S.K. and Binger, K.J. and Stegbauer, J. and Dechend, R. and Kleinewietfeld, M. and Jantsch, J. and Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
Geusz, R.J. and Wang, A. and Chiou, J. and Lancman, J.J. and Wetton, N. and Kefalopoulou, S. and Wang, J. and Qiu, Y. and Yan, J. and Aylward, A. and Ren, B. and Dong, P.D.S. and Gaulton, K.J. and Sander, M.
eLife 10 : e59067. 5 February 2021

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.
Geusz, R.J. and Wang, A. and Lam, D.K. and Vinckier, N.K. and Alysandratos, K.D. and Roberts, D.A. and Wang, J. and Kefalopoulou, S. and Ramirez, A. and Qiu, Y. and Chiou, J. and Gaulton, K.J. and Ren, B. and Kotton, D.N. and Sander, M.
Nature Communications 12 (1): 6636. 17 November 2021

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.
Giacopelli, B. and Wang, M. and Cleary, A. and Wu, Y.Z. and Schultz, A.R. and Schmutz, M. and Blachly, J.S. and Eisfeld, A.K. and Mundy-Bosse, B. and Vosberg, S. and Greif, P.A. and Claus, R. and Bullinger, L. and Garzon, R. and Coombes, K.R. and Bloomfield, C.D. and Druker, B.J. and Tyner, J.W. and Byrd, J.C. and Oakes, C.C.
Genome Research 31 (5): 747-761. May 2021

Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
Gillissen, B. and Richter, A. and Essmann, F. and Kemmner, W.
BMC Cancer 21 (1): 971. 30 August 2021

A novel remitting leukodystrophy associated with a variant in FBP2.
Gizak, A. and Diegmann, S. and Dreha-Kulaczewski, S. and Wiśniewski, J. and Duda, P. and Ohlenbusch, A. and Huppke, B. and Henneke, M. and Höhne, W. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Rakus, D. and Gärtner, J. and Huppke, P.
Brain Communications 3 (2): fcab036. 11 March 2021

Reliable kidney size determination by magnetic resonance imaging in pathophysiological settings.
Gladytz, T. and Millward, J.M. and Cantow, K. and Hummel, L. and Zhao, K. and Flemming, B. and Periquito, J.S. and Pohlmann, A. and Waiczies, S. and Seeliger, E. and Niendorf, T.
Acta Physiologica 233 (2): e13701. October 2021

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.
Glaser, L.V. and Steiger, M. and Fuchs, A. and van Bömmel, A. and Einfeldt, E. and Chung, H.R. and Vingron, M. and Meijsing, S.H.
Nucleic Acids Research 49 (21): 12178-12195. 2 December 2021

NEPHRO-ZEBRA-acute troponin increase in a kidney transplant recipient - the unknown knowns?
Goerlich, N. and Klingel, K. and Stangl, K. and Gaedeke, J. and Eckardt, K.U. and Kettritz, R.
Journal of Nephrology 34 (3): 931-933. June 2021

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.
Goetzke, C.C. and Althof, N. and Neumaier, H.L. and Heuser, A. and Kaya, Z. and Kespohl, M. and Klingel, K. and Beling, A.
Basic Research in Cardiology 116 (1): 7. 1 February 2021

Caution, "normal" BMI: health risks associated with potentially masked individual underweight - EPMA position paper 2021.
Golubnitschaja, O. and Liskova, A. and Koklesova, L. and Samec, M. and Biringer, K. and Büsselberg, D. and Podbielska, H. and Kunin, A.A. and Evsevyeva, M.E. and Shapira, N. and Paul, F. and Erb, C. and Dietrich, D.E. and Felbel, D. and Karabatsiakis, A. and Bubnov, R. and Polivka, J. and Polivka, J.J. and Birkenbihl, C. and Fröhlich, H. and Hofmann-Apitius, M. and Kubatka, P.
EPMA Journal 12 (3): 243-264. September 2021

The zinc finger antiviral protein ZAP restricts human cytomegalovirus and selectively binds and destabilizes viral UL4/UL5 transcripts.
Gonzalez-Perez, A.C. and Stempel, M. and Wyler, E. and Urban, C. and Piras, A. and Hennig, T. and Ganskih, S. and Wei, Y. and Heim, A. and Landthaler, M. and Pichlmair, A. and Dölken, L. and Munschauer, M. and Erhard, F. and Brinkmann, M.M.
mBio 12 (3): e02683-20. 4 May 2021

MLL1 is required for maintenance of intestinal stem cells.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
PLoS Genetics 17 (12): e1009250. 3 December 2021

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M. and Saraswat, M. and Bessière, C. and Menichelli, C. and Ramilowski, J.A. and Severin, J. and Hayashizaki, Y. and Itoh, M. and Tagami, M. and Murata, M. and Kojima-Ishiyama, M. and Noma, S. and Noguchi, S. and Kasukawa, T. and Hasegawa, A. and Suzuki, H. and Nishiyori-Sueki, H. and Frith, M.C. and Chatelain, C. and Carninci, P. and de Hoon, M.J.L. and Wasserman, W.W. and Bréhélin, L. and Lecellier, C.H.
Nature Communications 12 (1): 3297. 2 June 2021

Survivin’ acute myeloid leukaemia - a personalised target for inv(16) patients.
Greiner, J. and Brown, E. and Bullinger, L. and Hills, R.K. and Morris, V. and Döhner, H. and Mills, K.I. and Guinn, B.A.
International Journal of Molecular Sciences 22 (19): 10482. 1 October 2021

Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Griesi-Oliveira, K. and Fogo, M.S. and Pinto, B.G.G. and Alves, A.Y. and Suzuki, A.M. and Morales, A.G. and Ezquina, S. and Sosa, O.J. and Sutton, G.J. and Sunaga-Franze, D.Y. and Bueno, A.P. and Seabra, G. and Sardinha, L. and Costa, S.S. and Rosenberg, C. and Zachi, E.C. and Sertie, A.L. and Martins-de-Souza, D. and Reis, E.M. and Voineagu, I. and Passos-Bueno, M.R.
Molecular Psychiatry 26 (5): 1589-1605. May 2021

Development of SARA(home), a new video-based tool for the assessment of ataxia at home.
Grobe-Einsler, M. and Taheri Amin, A. and Faber, J. and Schaprian, T. and Jacobi, H. and Schmitz-Hübsch, T. and Diallo, A. and Tezenas du Montcel, S. and Klockgether, T.
Movement Disorders 36 (5): 1242-1246. May 2021

Neurochemical differences in spinocerebellar ataxia type 14 and 1.
Grosch, A.S. and Rinnenthal, J.L. and Rönnefarth, M. and Lux, S. and Scheel, M. and Endres, M. and Brandt, A.U. and Paul, F. and Schmitz-Hübsch, T. and Minnerop, M. and Doss, S.
Cerebellum 20 (2): 169-178. April 2021

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S. and Marenholz, I. and Esparza-Gordillo, J. and Arnau-Soler, A. and Pairo-Castineira, E. and Rüschendorf, F. and Ahluwalia, T.S. and Almqvist, C. and Arnold, A. and Baurecht, H. and Bisgaard, H. and Bønnelykke, K. and Brown, S.J. and Bustamante, M. and Curtin, J.A. and Custovic, A. and Dharmage, S.C. and Esplugues, A. and Falchi, M. and Fernandez-Orth, D. and Ferreira, M.A.R. and Franke, A. and Gerdes, S. and Gieger, C. and Hakonarson, H. and Holt, P.G. and Homuth, G. and Hubner, N. and Hysi, P.G. and Jarvelin, M.R. and Karlsson, R. and Koppelman, G.H. and Lau, S. and Lutz, M. and Magnusson, P.K.E. and Marks, G.B. and Müller-Nurasyid, M. and Nöthen, M.M. and Paternoster, L. and Pennell, C.E. and Peters, A. and Rawlik, K. and Robertson, C.F. and Rodriguez, E. and Sebert, S. and Simpson, A. and Sleiman, P.M.A. and Standl, M. and Stölzl, D. and Strauch, K. and Szwajda, A. and Tenesa, A. and Thompson, P.J. and Ullemar, V. and Visconti, A. and Vonk, J.M. and Wang, C.A. and Weidinger, S. and Wielscher, M. and Sargent, C.L. and Xu, C.J. and Lee, Y.A.
Nature Communications 12 (1): 6618. 16 November 2021

Parvalbumin interneurons are differentially connected to principal cells in inhibitory feedback microcircuits along the dorsoventral axis of the medial entorhinal cortex.
Grosser, S. and Barreda, F.J. and Beed, P. and Schmitz, D. and Booker, S.A. and Vida, I.
eNeuro 8 (1): ENEURO.0354-20.2020. 2 February 2021

A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization.
Grunewald, L. and Lam, T. and Andersch, L. and Klaus, A. and Schwiebert, S. and Winkler, A. and Gauert, A. and Heeren-Hagemann, A.I. and Astrahantseff, K. and Klironomos, F. and Thomas, A. and Deubzer, H.E. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Anders, K. and Kloke, L. and Künkele, A.
Frontiers in Immunology 12 : 689697. 29 June 2021

How to find genomic regions relevant for gene regulation.
Guo, X. and Ohler, U. and Yildirim, F.
Medizinische Genetik 33 (2): 157-165. 14 August 2021

Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta, S. and Short, S.A.P. and Sise, M.E. and Prosek, J.M. and Madhavan, S.M. and Soler, M.J. and Ostermann, M. and Herrmann, S.M. and Abudayyeh, A. and Anand, S. and Glezerman, I. and Motwani, S.S. and Murakami, N. and Wanchoo, R. and Ortiz-Melo, D.I. and Rashidi, A. and Sprangers, B. and Aggarwal, V. and Malik, A.B. and Loew, S. and Carlos, C.A. and Chang, W.T. and Beckerman, P. and Mithani, Z. and Shah, C.V. and Renaghan, A.D. and Seigneux, S.D. and Campedel, L. and Kitchlu, A. and Shin, D.S. and Rangarajan, S. and Deshpande, P. and Coppock, G. and Eijgelsheim, M. and Seethapathy, H. and Lee, M.D. and Strohbehn, I.A. and Owen, D.H. and Husain, M. and Garcia-Carro, C. and Bermejo, S. and Lumlertgul, N. and Seylanova, N. and Flanders, L. and Isik, B. and Mamlouk, O. and Lin, J.S. and Garcia, P. and Kaghazchi, A. and Khanin, Y. and Kansal, S.K. and Wauters, E. and Chandra, S. and Schmidt-Ott, K.M. and Hsu, R.K. and Tio, M.C. and Sarvode Mothi, S. and Singh, H. and Schrag, D. and Jhaveri, K.D. and Reynolds, K.L. and Cortazar, F.B. and Leaf, D.E.
Journal for ImmunoTherapy of Cancer 9 (10): e003467. October 2021

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.
Gurumayum, S. and Jiang, P. and Hao, X. and Campos, T.L. and Young, N.D. and Korhonen, P.K. and Gasser, R.B. and Bork, P. and Zhao, X.M. and He, L.J. and Chen, W.H.
Nucleic Acids Research 49 (D1): D998-D1003. 8 January 2021

CRISPRi screens reveal genes modulating yeast growth in lignocellulose hydrolysate.
Gutmann, F. and Jann, C. and Pereira, F. and Johansson, A. and Steinmetz, L.M. and Patil, K.R.
Biotechnology for Biofuels 14 (1): 41. 10 February 2021

Cellular basis of ClC-2 Cl(-) channel-related brain and testis pathologies.
Göppner, C. and Soria, A.H. and Hoegg-Beiler, M.B. and Jentsch, T.J.
Journal of Biological Chemistry 296 : 100074. 4 January 2021

Bionic tracking: using eye tracking to track biological cells in virtual reality.
Günther, U. and Harrington, K.I.S. and Dachselt, R. and Sbalzarini, I.F.
Lecture Notes in Computer Science 12535 : 280-297. 2021

Energy metabolites as biomarkers in ischemic and dilated cardiomyopathy.
Haas, J. and Frese, K.S. and Sedaghat-Hamedani, F. and Kayvanpour, E. and Tappu, R. and Nietsch, R. and Tugrul, O.F. and Wisdom, M. and Dietrich, C. and Amr, A. and Weis, T. and Niederdränk, T. and Murphy, M.P. and Krieg, T. and Dörr, M. and Völker, U. and Fielitz, J. and Frey, N. and Felix, S.B. and Keller, A. and Katus, H.A. and Meder, B.
International Journal of Molecular Sciences 22 (4): 1999. 18 February 2021

Propionic acid rescues high-fat diet enhanced immunopathology in autoimmunity via effects on Th17 responses.
Haase, S. and Mäurer, J. and Duscha, A. and Lee, D.H. and Balogh, A. and Gold, R. and Müller, D.N. and Haghikia, A. and Linker, R.A.
Frontiers in Immunology 12 : 701626. 1 June 2021

Ion transporter NKCC1, modulator of neurogenesis in murine olfactory neurons.
Haering, C. and Kanageswaran, N. and Bouvain, P. and Scholz, P. and Altmüller, J. and Becker, C. and Gisselmann, G. and Wäring-Bischof, J. and Hatt, H.
Journal of Biological Chemistry 290 (15): 9767-9779. 4 January 2021

A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3.
Halatsch, M.E. and Kast, R.E. and Karpel-Massler, G. and Mayer, B. and Zolk, O. and Schmitz, B. and Scheuerle, A. and Maier, L. and Bullinger, L. and Mayer-Steinacker, R. and Schmidt, C. and Zeiler, K. and Elshaer, Z. and Panther, P. and Schmelzle, B. and Hallmen, A. and Dwucet, A. and Siegelin, M.D. and Westhoff, M.A. and Beckers, K. and Bouche, G. and Heiland, T.
Neuro-Oncology Advances 3 (1): vdab075. 7 August 2021

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P. and Mustroph, J. and Stauber, T. and Birchmeier, W. and Wagner, S. and Maier, L.S.
PLoS ONE 16 (6): e0252649. 4 June 2021

Multi-channel RF supervision module for thermal magnetic resonance based cancer therapy.
Han, H. and Oberacker, E. and Kuehne, A. and Wang, S. and Eigentler, T.W. and Grass, E. and Niendorf, T.
Cancers 13 (5): 1001. 28 February 2021

Critical illness and systemic inflammation are key risk factors of severe acute kidney injury in patients with COVID-19.
Hardenberg, J.H.B. and Stockmann, H. and Aigner, A. and Gotthardt, I. and Enghard, P. and Hinze, C. and Balzer, F. and Schmidt, D. and Zickler, D. and Kruse, J. and Körner, R. and Stegemann, M. and Schneider, T. and Schumann, M. and Müller-Redetzky, H. and Angermair, S. and Budde, K. and Weber-Carstens, S. and Witzenrath, M. and Treskatsch, S. and Siegmund, B. and Spies, C. and Suttorp, N. and Rauch, G. and Eckardt, K.U. and Schmidt-Ott, K.M.
Kidney International Reports 6 (4): 905-915. April 2021

Genome-wide analysis of actively translated open reading frames using riboTaper/ORFquant.
Harnett, D. and Meerdink, E. and Calviello, L. and Sydow, D. and Ohler, U.
Methods in Molecular Biology 2252 : 331-346. 2021

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.
Harper, A.R. and Goel, A. and Grace, C. and Thomson, K.L. and Petersen, S.E. and Xu, X. and Waring, A. and Ormondroyd, E. and Kramer, C.M. and Ho, C.Y. and Neubauer, S. and Tadros, R. and Ware, J.S. and Bezzina, C.R. and Farrall, M. and Watkins, H.
Nature Genetics 53 (2): 135-142. February 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A. and Sieverling, L. and Nadler-Holly, M. and Ziehm, M. and Toprak, U.H. and Herrmann, C. and Ishaque, N. and Okonechnikov, K. and Gartlgruber, M. and Park, Y.G. and Wecht, E.M. and Savelyeva, L. and Henrich, K.O. and Rosswog, C. and Fischer, M. and Hero, B. and Jones, D.T.W. and Pfaff, E. and Witt, O. and Pfister, S.M. and Volckmann, Ri. and Koster, J. and Kiesel, K. and Rippe, K. and Taschner-Mandl, S. and Ambros, P. and Brors, B. and Selbach, M. and Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Delayed access to conscious processing in multiple sclerosis: reduced cortical activation and impaired structural connectivity.
Has Silemek, A.C. and Ranjeva, J.P. and Audoin, B. and Heesen, C. and Gold, S.M. and Kühn, S. and Weygandt, M. and Stellmann, J.P.
Human Brain Mapping 42 (11): 3379-3395. 1 August 2021

Insulin-like growth factor binding protein-2 (IGFBP2) is a key molecule in the MACC1-mediated platelet communication and metastasis of colorectal cancer cells.
Haschemi, R. and Kobelt, D. and Steinwarz, E. and Schlesinger, M. and Stein, U. and Bendas, G.
International Journal of Molecular Sciences 22 (22): 12195. 11 November 2021

Stepwise conformational stabilization of a HIV-1 Clade C consensus envelope trimer immunogen impacts the profile of vaccine-induced antibody responses.
Hauser, A. and Carnell, G. and Held, K. and Sulbaran, G. and Tischbierek, N. and Rogers, L. and Pollakis, G. and Tonks, P. and Hoelscher, M. and Ding, S. and Sanders, R.W. and Geldmacher, C. and Sattentau, Q. and Weissenhorn, W. and Heeney, J.L. and Peterhoff, D. and Wagner, R.
Vaccines 9 (7): 750. 6 July 2021

Artificially produced gametes in mice, humans and other species.
Hayashi, K. and Galli, C. and Diecke, S. and Hildebrandt, T.B.
Reproduction Fertility and Development 33 (2): 91-101. 8 January 2021

CD4+ T cell dependent B cell recovery and function after autologous hematopoietic stem cell transplantation.
Heck, C. and Steiner, S. and Kaebisch, E.M. and Frentsch, M. and Wittenbecher, F. and Scheibenbogen, C. and Hanitsch, L.G. and Nogai, A. and le Coutre, P. and Bullinger, L. and Blau, I.W. and Na, I.K.
Frontiers in Immunology 12 : 736137. September 2021

Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA) extended follow-up of a 2×2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol.
Heck, S.L. and Mecinaj, A. and Ree, A.H. and Hoffmann, P. and Schulz-Menger, J.E. and Fagerland, M.W. and Gravdehaug, B. and Røsjø, H. and Steine, K. and Geisler, J. and Gulati, G. and Omland, T.
Circulation 143 (25): 2431-2440. 22 June 2021

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, M. and Eichner, R. and Stroh, J. and Morath, V. and Kuisl, A. and Zecha, J. and Lawatscheck, J. and Baek, K. and Garz, A.K. and Rudelius, M. and Deuschle, F.C. and Keller, U. and Lemeer, S. and Verbeek, M. and Götze, K.S. and Skerra, A. and Weber, W.A. and Buchner, J. and Schulman, B.A. and Kuster, B. and Fernández-Sáiz, V. and Bassermann, F.
Molecular Cell 81 (6): 1170-1186. 18 March 2021

Preoperative comparison of three anticholinergic drug scales in older adult patients and development of postoperative delirium: a prospective observational study.
Heinrich, M. and Müller, A. and Cvijan, A. and Mörgeli, R. and Kruppa, J. and Winterer, G. and Slooter, A.J.C. and Spies, C.D.
Drugs & Aging 38 (4): 347-354. April 2021

Preoperative medication use and development of postoperative delirium and cognitive dysfunction.
Heinrich, M. and Nottbrock, A. and Borchers, F. and Mörgeli, R. and Kruppa, J. and Winterer, G. and Slooter, A.J.C. and Spies, C.
Clinical and Translational Science 14 (5): 1830-1840. September 2021

Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients.
Heinrich, M. and Sieg, M. and Kruppa, J. and Nürnberg, P. and Schreier, P.H. and Heilmann-Heimbach, S. and Hoffmann, P. and Nöthen, M.M. and Janke, J. and Pischon, T. and Slooter, A.J.C. and Winterer, G. and Spies, C.D.
BMC Medical Genomics 14 : 248. 21 October 2021

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Heller, S. and Li, Z. and Lin, Q. and Geusz, R. and Breunig, M. and Hohwieler, M. and Zhang, X. and Nair, G.G. and Seufferlein, T. and Hebrok, M. and Sander, M. and Julier, C. and Kleger, A. and Costa, I.G.
Communications Biology 4 (1): 1298. 17 November 2021

A comparison of nine machine learning mutagenicity models and their application for predicting pyrrolizidine alkaloids.
Helma, C. and Schöning, V. and Drewe, J. and Boss, P.
Frontiers in Pharmacology 12 : 708050. 22 July 2021

Dual-color fluorescence cross-correlation spectroscopy to study protein-protein interaction and protein dynamics in live cells.
Hemmen, K. and Choudhury, S. and Friedrich, M. and Balkenhol, J. and Knote, F. and Lohse, M.J. and Heinze, K.G.
Journal of Visualized Experiments 178 : e62954. 11 December 2021

Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects.
Henke, C. and Haufe, S. and Ziehl, D. and Bornstein, S.R. and Schulz-Menger, J. and Heni, M. and Engeli, S. and Jordan, J. and Birkenfeld, A.L.
ESC Heart Failure 8 (2): 938-942. April 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S. and Heimann, A. and Obermayer, B. and Ciraolo, E. and Althoff, S. and Ruß, J. and Grunert, C. and Busse, A. and Bullinger, L. and Pezzutto, A. and Blankenstein, T. and Beule, D. and Na, I.K.
International Journal of Cancer 148 (12): 3097-3110. 15 June 2021

Simultaneous T(2) and T(2)* mapping of multiple sclerosis lesions with radial RARE-EPI.
Herrmann, C. and Els, A. and Boehmert, L. and Periquito, J. and Eigentler, T.W. and Millward, J. and Waiczies, S. and Kuchling, J. and Paul, F. and Niendorf, T.
Magnetic Resonance in Medicine 86 (3): 1383-1402. September 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations.
Heuser, M. and Heida, B. and Büttner, K. and Wienecke, C.P. and Teich, K. and Funke, C. and Brandes, M. and Klement, P. and Liebich, A. and Wichmann, M. and Neziri, B. and Chaturvedi, A. and Kloos, A. and Mintzas, K. and Gaidzik, V.I. and Paschka, P. and Bullinger, L. and Fiedler, W. and Heim, A. and Puppe, W. and Krauter, J. and Döhner, K. and Döhner, H. and Ganser, A. and Stadler, M. and Hambach, L. and Gabdoulline, R. and Thol, F.
Blood Advances 5 (9): 2294-2304. 11 May 2021

Dispersal strategies shape persistence and evolution of human gut bacteria.
Hildebrand, F. and Gossmann, T.I. and Frioux, C. and Özkurt, E. and Myers, P.N. and Ferretti, P. and Kuhn, M. and Bahram, M. and Nielsen, H.B. and Bork, P.
Cell Host & Microbe 29 (7): 1167-1176. 14 June 2021

The ART of bringing extinction to a freeze - history and future of species conservation, exemplified by rhinos.
Hildebrandt, T.B. and Hermes, R. and Goeritz, F. and Appeltant, R. and Colleoni, S. and de Mori, B. and Diecke, S. and Drukker, M. and Galli, C. and Hayashi, K. and Lazzari, G. and Loi, P. and Payne, J. and Renfree, M. and Seet, S. and Stejskal, J. and Swegen, A. and Williams, S.A. and Zainuddin, Z.Z. and Holtze, S.
Theriogenology 169 : 76-88. 15 July 2021

Conservation research in times of COVID-19 - the rescue of the northern white rhino.
Hildebrandt, T.B. and Holtze, S. and Biasetti, P. and Colleoni, S. and de Mori, B. and Diecke, S. and Göritz, F. and Hayashi, K. and Hayashi, M. and Hermes, R. and Kariuki, L. and Lazzari, G. and Mijele, D. and Mutisya, S. and Ndeereh, D. and Ngulu, S. and Seet, S. and Zwilling, J. and Zywitza, V. and Stejskal, J. and Galli, C.
Journal of Applied Animal Ethics Research 3 (1): 16-37. May 2021

Construction of whole genomes from scaffolds using single cell strand-seq data.
Hills, M. and Falconer, E. and O'Neill, K. and Sanders, A.D. and Howe, K. and Guryev, V. and Lansdorp, P.M.
International Journal of Molecular Sciences 22 (7): 3617. 1 April 2021

Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C. and Karaiskos, N. and Boltengagen, A. and Walentin, K. and Redo, K. and Himmerkus, N. and Bleich, M. and Potter, S.S. and Potter, A.S. and Eckardt, K.U. and Kocks, C. and Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32 (2): 291-306. February 2021

A public health antibody screening indicates a 6-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M. and Holthaus, L. and Assfalg, R. and Zapardiel Gonzalo, J.M. and Kapfelsperger, H. and Heigermoser, M. and Haupt, F. and Ewald, D.A. and Welzhofer, T.C. and Marcus, B.A. and Heck, S. and Koelln, A. and Stock, J. and Voss, F. and Secchi, M. and Piemonti, L. and de la Rosa, K. and Protzer, U. and Boehmer, M. and Achenbach, P. and Lampasona, V. and Bonifacio, E. and Ziegler, A.G.
Med 2 (2): 149-163. 12 February 2021

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
Ho, J.S. and Di Tullio, F. and Schwarz, M. and Low, D. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J.X. and Wollmann, H. and Chen, L. and An, O. and Chan, T.H.M. and Hall Hickman, A. and Zheng, S. and Roudko, V. and Chen, S. and Karz, A. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Oliviero, S. and Serresi, M. and Gargiulo, G. and Mann, K.M. and Hernando, E. and Mulholland, D. and Marazzi, I. and Wee, D.K.B. and Guccione, E.
eLife 10 : e59654. 2 June 2021

Gene expression signatures of a preclinical mouse model during colorectal cancer progression under low-dose metronomic chemotherapy.
Ho-Xuan, H. and Lehmann, G. and Glazar, P. and Gypas, F. and Eichner, N. and Heizler, K. and Schlitt, H.J. and Zavolan, M. and Rajewsky, N. and Meister, G. and Hackl, C.
Cancers 13 (1): 49. 2021

Gynecological cancer and omega-3 fatty acid intakes: meta-analysis.
Hoang, T. and Myung, S.K. and Pham, T.T.
Asia Pacific Journal of Clinical Nutrition 30 (1): 153-162. March 2021

Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J. and Luxán, G. and Abplanalp, W.T. and Glaser, S.F. and Rasper, T. and Fischer, A. and Muhly-Reinholz, M. and Potente, M. and Assmus, B. and John, D. and Zeiher, A.M. and Dimmeler, S.
Nature Communications 12 (1): 3964. 25 June 2021

Sollten Patienten nach überlebter akuter Nierenschädigung mit RAAS-Inhibitoren behandelt werden? [Should patients after surviving acute kidney injury be treated with RAAS inhibitors?].
Hoffmann, L. and Schmidt-Ott, K.M.
Nephrologe 16 (5): 305-306. September 2021

Agonistic autoantibodies against β2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients.
Hohberger, B. and Hosari, S. and Wallukat, G. and Kunze, R. and Krebs, J. and Müller, M. and Hennig, T. and Lämmer, R. and Horn, F. and Muñoz, L.E. and Herrmann, M. and Mardin, C.
PLoS ONE 16 (5): e0249202. 7 May 2021

Inhibitory and agonistic autoantibodies directed against the ß(2)-adrenergic receptor in pseudoexfoliation syndrome and glaucoma.
Hohberger, B. and Schlötzer-Schrehard, U. and Mardin, C. and Lämmer, R. and Munoz, L. and Kunze, R. and Herrmann, M. and Wallukat, G.
Frontiers in Neuroscience 15 : 676579. 6 August 2021

Agonistic β2-adrenergic receptor autoantibodies characterize the aqueous humor of patients with primary and secondary open-angle glaucoma.
Hohberger, B. and Wörn, M. and Lämmer, R. and Mahajan, A. and Mardin, C. and Schötzer-Schrehardt, U. and Kunze, R. and Herrmann, M. and Wallukat, G.
Frontiers in Immunology 12 : 550236. 5 May 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: results from the CONKO-005 trial.
Hoyer, K. and Hablesreiter, R. and Inoue, Y. and Yoshida, K. and Briest, F. and Christen, F. and Kakiuchi, N. and Yoshizato, T. and Shiozawa, Y. and Shiraishi, Y. and Striefler, J.K. and Bischoff, S. and Lohneis, P. and Putter, H. and Blau, O. and Keilholz, U. and Bullinger, L. and Pelzer, U. and Hummel, M. and Riess, H. and Ogawa, S. and Sinn, M. and Damm, F.
EBioMedicine 66 : 103327. April 2021

CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains.
Huang, H. and Zhu, Q. and Jussila, A. and Han, Y. and Bintu, B. and Kern, C. and Conte, M. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Yu, M. and Hu, R. and Tastemel, M. and Juric, I. and Hu, M. and Nicodemi, M. and Zhuang, X. and Ren, B.
Nature Genetics 53 (7): 1064-1074. July 2021

Glial cell line‐derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia‐mediated glioma progression.
Huang, Y. and Zhang, B. and Haneke, H. and Haage, V. and Lubas, M. and Yuan, Y. and Xia, P. and Motta, E. and Nanvuma, C. and Dzaye, O. and Hu, F. and Kettenmann, H.
Journal of Neuroscience Research 99 (4): 1048-1063. April 2021

Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Huhn, K. and Linz, P. and Pemsel, F. and Michalke, B. and Seyferth, S. and Kopp, C. and Chaudri, M.A. and Rothhammer, V. and Dörfler, A. and Uder, M. and Nagel, A.M. and Müller, D.N. and Waschbisch, A. and Lee, D.H. and Bäuerle, T. and Linker, R.A. and Haase, S.
Proceedings of the National Academy of Sciences of the United States of America 118 (28): e2102549118. 13 July 2021

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L. and Yost, K.E. and Xie, L. and Shi, Q. and Helmsauer, K. and Luebeck, J. and Schöpflin, R. and Lange, J.T. and Chamorro González, R. and Weiser, N.E. and Chen, C. and Valieva, M.E. and Wong, I.T.L. and Wu, S. and Dehkordi, S.R. and Duffy, C.V. and Kraft, K. and Tang, J. and Belk, J.A. and Rose, J.C. and Corces, M.R. and Granja, J.M. and Li, R. and Rajkumar, U. and Friedlein, J. and Bagchi, A. and Satpathy, A.T. and Tjian, R. and Mundlos, S. and Bafna, V. and Henssen, A.G. and Mischel, P.S. and Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Hur, J. and Otegbeye, E. and Joh, H.K. and Nimptsch, K. and Ng, K. and Ogino, S. and Meyerhardt, J.A. and Chan, A.T. and Willett, W.C. and Wu, K. and Giovannucci, E. and Cao, Y.
Gut 70 (12): 2330-2336. December 2021

Cortisol dose-dependently impairs migration and tube-like formation in a trophoblast cell line and modulates inflammatory and angiogenic genes.
Húngaro, T.G.R and Gregnani, M.F. and Alves-Silva, T. and Herse, F. and Alenina, N. and Bader, M. and Araújo, R.C.
Biomedicines 9 (8): 980. August 2021

A prospective of multiple biopharmaceutical activities of procyanidins‐rich Uapaca togoensis pax extracts: HPLC‐ESI‐TOF‐MS coupled with bioinformatics analysis.
Ibrahime Sinan, K. and Aktumsek, A. and de la Luz Cádiz‐Gurrea, M. and Leyva‐Jiménez, F.J. and Fernández-Ochoa, Á. and Segura‐Carretero, A. and Glamocilja, J. and Sokovic, M. and Nenadić, M. and Zengin, G.
Chemistry & Biodiversity 18 (8): e2100299. 18 August 2021

Apple peel and flesh contain pro-neurogenic compounds.
Ichwan, M. and Walker, T.L. and Nicola, Z. and Ludwig-Müller, J. and Böttcher, C. and Overall, R.W. and Adusumilli, V.S. and Bulut, M. and Sykes, A.M. and Hübner, N. and Ramirez-Rodriguez, G. and Ortiz-López, L. and Lugo-Hernández, E.A. and Kempermann, G.
Stem Cell Reports 16 (3): 548-565. 9 March 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. and Sigal, M.
International Journal of Medical Microbiology 311 (3): 151486. April 2021

Clinical outcome of older adults with acute myeloid leukemia: an analysis of a large tertiary referral center over two decades.
Ihlow, J. and Gross, S. and Neuendorff, N.R. and Busack, L. and Herneth, A. and Singh, A. and Schwarz, M. and Flörcken, A. and Anagnostopoulos, I. and Türkmen, S. and Burmeister, T. and Blau, I.W. and Bullinger, L. and Westermann, J.
Journal of Geriatric Oncology 12 (4): 540-549. May 2021

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.
Ihlow, J. and Michaelis, E. and Greuel, S. and Heynol, V. and Lehmann, A. and Radbruch, H. and Meinhardt, J. and Miller, F. and Herbst, H. and Corman, V.M. and Westermann, J. and Bullinger, L. and Horst, D. and von Brünneck, A.C. and Elezkurtaj, S.
International Journal of Infectious Diseases 103 : 628-635. February 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F. and Dahlmann, M. and Sporbert, A. and Ciolli Mattioli, C. and Mari, T. and Scholz, F. and Timm, L. and Twamley, S. and Migotti, R. and Walther, W. and Dittmar, G. and Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Subiculum as a generator of sharp wave-ripples in the rodent hippocampus.
Imbrosci, B. and Nitzan, N. and McKenzie, S. and Donoso, J.R. and Swaminathan, A. and Böhm, C. and Maier, N and Schmitz, D.
Cell Reports 35 (3): 109021. 20 April 2021

Bioenergetic profiling of human pluripotent stem cells.
Inak, G. and Henke, M.T. and Prigione, A.
Methods in Molecular Biology 2277 : 391-403. 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies.
Iqbal, M. and Maroofian, R. and Çavdarlı, B. and Riccardi, F. and Field, M. and Banka, S. and Bubshait, D.K. and Li, Y. and Hertecant, J. and Baig, S.M. and Dyment, D. and Efthymiou, S. and Abdullah, U. and Makhdoom, E.U.H. and Ali, Z. and Scherf de Almeida, T and Molinari, F. and Mignon-Ravix, C. and Chabrol, B. and Antony, J. and Ades, L. and Pagnamenta, A.T. and Jackson, A. and Douzgou, S. and Beetz, C. and Karageorgou, V. and Vona, B. and Rad, A. and Baig, J.M. and Sultan, T. and Alvi, J.R. and Maqbool, S. and Rahman, F. and Toosi, M.B. and Ashrafzadeh, F. and Imannezhad, S. and Karimiani, E.G. and Sarwar, Y. and Khan, S. and Jameel, M. and Noegel, A.A. and Budde, B. and Altmüller, J. and Motameny, S. and Höhne, W. and Houlden, H. and Nürnberg, P. and Wollnik, B. and Villard, L. and Alkuraya, F.S. and Osmond, M. and Hussain, M.S. and Yigit, G.
Genetics in Medicine 23 (11): 2138-2149. November 2021

Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold.
Irmscher, T. and Roske, Y. and Gayk, I. and Dunsing, V. and Chiantia, S. and Heinemann, U. and Barbirz, S.
Journal of Biological Chemistry 296 : 100286. 2021

Dolosigranulum pigrum modulates immunity against SARS-CoV-2 in respiratory epithelial cells.
Islam, M.A. and Albarracin, L. and Melnikov, V. and Andrade, B.G.N. and Cuadrat, R.R.C. and Kitazawa, H. and Villena, J.
Pathogens 10 (6): 634. 21 May 2021

Immunobiotic Lactobacilli improve resistance of respiratory epithelial cells to SARS-CoV-2 infection.
Islam, M.A. and Albarracin, L. and Tomokiyo, M. and Valdez, J.C. and Sacur, J. and Vizoso-Pinto, M.G. and Andrade, B.G.N. and Cuadrat, R.C. and Kitazawa, H. and Villena, J.
Pathogens 10 (9): 1197. September 2021

Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A. and Serfling, R. and Möller, J. and Thomas, R. and De Faveri, C. and Zabel, U. and Scarselli, M. and Beck-Sickinger, A.G. and Bock, A. and Coin, I. and Lohse, M.J. and Annibale, P.
Nature Protocols 16 (3): 1419-1451. March 2021

Sulfoxide-functionalized nanogels inspired by the skin penetration properties of DMSO.
Işık, D. and Joshi, A.A. and Guo, X. and Rancan, F. and Klossek, A. and Vogt, A. and Rühl, E. and Hedtrich, S. and Klinger, D.
Biomaterials science 9 (3): 712-725. 7 February 2021

Assessing dysferlinopathy patients over three years with a new motor scale.
Jacobs, M. and James, M.K. and Lowes, L.P. and Alfano, L.N. and Eagle, M. and Lofra, R.M. and Moore, U. and Feng, J. and Rufibach, L.E. and Rose, K. and Duong, T. and Bello, L. and Pedrosa-Hernández, I. and Holsten, S. and Sakamoto, C. and Canal, A. and Práxedes, N.S.A. and Thiele, S. and Siener, C. and Vandevelde, B. and DeWolf, B. and Maron, E. and Guglieri, M. and Hogrel, J.Y. and Blamire, A.M. and Carlier, P.G. and Spuler, S. and Day, J.W. and Jones, K.J. and Bharucha-Goebel, D.X. and Salort-Campana, E. and Pestronk, A. and Walter, M.C. and Paradas, C. and Stojkovic, T. and Mori-Yoshimura, M. and Bravver, E. and Díaz-Manera, J. and Pegoraro, E. and Mendell, J.R. and Mayhew, A.G. and Straub, V.
Annals of Neurology 89 (5): 967-978. May 2021

Analysis of renal diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models.
Jerome, N.P. and Periquito, J.S.
Methods in Molecular Biology 2216 : 611-635. 2021

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang, H. and Hooper, C. and Kelly, M. and Steeples, V. and Simon, J.N. and Beglov, J. and Azad, A.J. and Leinhos, L. and Bennett, P. and Ehler, E. and Kalisch-Smith, J.I. and Sparrow, D.B. and Fischer, R. and Heilig, R. and Isackson, H. and Ehsan, M. and Patone, G. and Huebner, N. and Davies, B. and Watkins, H. and Gehmlich, K.
Basic Research in Cardiology 116 (1): 14. 26 February 2021

Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease.
Jiang, Y. and Müller, K. and Khan, M.A. and Assmann, J.C. and Lampe, J. and Kilau, K. and Richter, M. and Kleint, M. and Ridder, D.A. and Hübner, N. and Schmidt-Supprian, M. and Wenzel, J. and Schwaninger, M.
Journal of Cerebral Blood Flow and Metabolism 41 (2): 219-235. 1 February 2021

Sodium and its manifold impact on our immune system.
Jobin, K. and Müller, D.N. and Jantsch, J. and Kurts, C.
Trends in Immunology 42 (6): 469-479. June 2021

Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp.
Joh, H.K. and Lee, D.H. and Hur, J. and Nimptsch, K. and Chang, Y. and Joung, H. and Zhang, X. and Rezende, L.F.M. and Lee, J.E. and Ng, K. and Chen, Y. and Tabung, F.K. and Meyerhardt, J.A. and Chan, A.T. and Pischon, T. and Song, M. and Fuchs, C.S. and Willett, W.C. and Cao, Y. and Ogino, S. and Giovannucci, E. and Wu, K.
Gastroenterology 161 (1): 128-142. July 2021

Electroporation-based genetic modification of primary human pigment epithelial cells using the Sleeping Beauty transposon system.
Johnen, S. and Harmening, N. and Marie, C. and Scherman, D. and Izsvák, Z. and Ivics, Z. and Walter, P. and Thumann, G.
Journal of Visualized Experiments (168): e61987. February 2021

The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life.
Kaczmarczyk, M. and Löber, U. and Adamek, K. and Węgrzyn, D. and Skonieczna-Żydecka, K. and Malinowski, D. and Łoniewski, I. and Markó, L. and Ulas, T. and Forslund, S.K. and Łoniewska, B.
Journal of Translational Medicine 19 (1): 177. 28 April 2021

Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser, R. and Leunig, A. and Pekayvaz, K. and Popp, O. and Joppich, M. and Polewka, V. and Escaig, R. and Anjum, A. and Hoffknecht, M.L. and Gold, C. and Brambs, S. and Engel, A. and Stockhausen, S. and Knottenberg, V. and Titova, A. and Haji, M. and Scherer, C. and Muenchhoff, M. and Hellmuth, J.C. and Saar, K. and Schubert, B. and Hilgendorff, A. and Schulz, C. and Kääb, S. and Zimmer, R. and Hübner, N. and Massberg, S. and Mertins, P. and Nicolai, L. and Stark, K.
JCI Insight 6 (18): e150862. 22 September 2021

Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Kalveram, L. and Schunck, W.H. and Rothe, M. and Rudolph, B. and Loddenkemper, C. and Holzhütter, H.G. and Henning, S. and Bufler, P. and Schulz, M. and Meierhofer, D. and Zhang, I.W. and Weylandt, K.H. and Wiegand, S. and Hudert, C.A.
Prostaglandins Leukotrienes and Essential Fatty Acids 164 : 102229. January 2021

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N. and Roske, Y. and Kovalskyy, D. and Platonov, M.O. and Balinskyi, O. and Kreuchwig, A. and Saupe, J. and Fang, L. and Diehl, A. and Schmieder, P. and Krause, G. and Rademann, J. and Heinemann, U. and Birchmeier, W. and Oschkinat, H.
Magnetic Resonance 2 (1): 355-374. 2 June 2021

Breeding and maintenance of immunodeficient mouse lines under SPF conditions - a call for individualized severity analyses and approval procedures.
Kammertoens, T. and Jeuthe, S. and Baranzke, H. and Klippert, A. and Thöne-Reineke, C.
Animals 11 (6): 1789. June 2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Kargapolova, Y. and Rehimi, R. and Kayserili, H. and Brühl, J. and Sofiadis, K. and Zirkel, A. and Palikyras, S. and Mizi, A. and Li, Y. and Yigit, G. and Hoischen, A. and Frank, S. and Russ, N. and Trautwein, J. and van Bon, B. and Gilissen, C. and Laugsch, M. and Gusmao, E.G. and Josipovic, N. and Altmüller, J. and Nürnberg, P. and Längst, G. and Kaiser, F.J. and Watrin, E. and Brunner, H. and Rada-Iglesias, A. and Kurian, L. and Wollnik, B. and Bouazoune, K. and Papantonis, A.
Nature Communications 12 (1): 3014. 21 May 2021

Diagnostik und Therapie von statinassoziierten Muskelsymptomen [Diagnostics and treatment of statin-associated muscle symptoms].
Kassner, U. and Grunwald, S. and Spira, D. and Buchmann, N. and Bobbert, T. and Gazzerro, E. and Hollstein, T. and Spuler, S. and Steinhagen-Thiessen, E.
Internist 62 : 827-840. August 2021

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. and Subramaniam, S. and Chomsky-Hecht, O. and Tsemakhovich, V. and Flockerzi, V. and Klussmann, E. and Hirsch, J.A. and Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Preparation and monitoring of small animals in renal MRI.
Kaucsar, T. and Hosszu, A. and Seeliger, E. and Reimann, H.M. and Fekete, A.
Methods in Molecular Biology 2216 : 45-55. 2021

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
Kayser, S. and Schlenk, R.F. and Lebon, D. and Carre, M. and Götze, K.S. and Stölzel, F. and Berceanu, A. and Schäfer-Eckart, K. and Peterlin, P. and Hicheri, Y. and Rahme, R. and Raffoux, E. and Chermat, F. and Krause, S.W. and Aulitzky, W.E. and Rigaudeau, S. and Noppeney, R. and Berthon, C. and Görner, M. and Jost, E. and Carassou, P. and Keller, U. and Orvain, C. and Braun, T. and Saillard, C. and Arar, A. and Kunzmann, V. and Wemeau, M. and De Wit, M. and Niemann, D. and Bonmati, C. and Schwänen, C. and Abraham, J. and Aljijakli, A. and Haiat, S. and Krämer, A. and Reichle, A. and Gnadler, M. and Willekens, C. and Spiekermann, K. and Hiddemann, W. and Müller-Tidow, C. and Thiede, C. and Röllig, C. and Serve, H. and Bornhäuser, M. and Baldus, C.D. and Lengfelder, E. and Fenaux, P. and Platzbecker, U. and Adès, L.
Haematologica 106 (12): 3100-3106. December 2021

The CONJUDOR pipeline for multiplexed knockdown of gene pairs identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans.
Kazmierczak, M. and Farré i Díaz, C. and Ofenbauer, A. and Herzog, S. and Tursun, B.
Nucleic Acids Research 49 (4): e22. 26 February 2021

Kidney injury caused by preeclamptic pregnancy recovers postpartum in a transgenic rat model.
Kedziora, S.M. and Kräker, K. and Markó, L. and Binder, J. and Sugulle, M. and Gauster, M. and Mueller, D.N. and Dechend, R. and Haase, N. and Herse, F.
International Journal of Molecular Sciences 22 (7): 3762. 5 April 2021

Genomic variants causing mitochondrial dysfunction are common in hereditary lower motor neuron disease.
Keller, N. and Paketci, C. and Altmueller, J. and Fuhrmann, N. and Wunderlich, G. and Schrank, B. and Unver, O. and Yilmaz, S. and Boostani, R. and Karimiani, E.G. and Motameny, S. and Thiele, H. and Nürnberg, P. and Maroofian, R. and Yis, U. and Wirth, Br. and Karakaya, M.
Human Mutation 42 (4): 460-472. April 2021

Profiling of sub-lethal in vitro effects of multi-walled carbon nanotubes reveals changes in chemokines and chemokine receptors.
Keshavan, S. and Andón, F.T. and Gallud, A. and Chen, W. and Reinert, K. and Tran, L. and Fadeel, B.
Nanomaterials 11 (4): 883. 30 March 2021

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K. and Kaljunen, H. and Taavitsainen, S. and Kaarijärvi, R. and Järvelä, E. and Rodriguez Martin, B. and Haase, K. and Woodcock, D.J. and Tubio, J. and Wedge, D.C. and Nykter, M. and Bova, G.S.
Cancer Research 81 (19): 4901-4909. October 2021

Hyponatriämie - Ursachen, Diagnostik und Therapie [Hyponatremia - causes, diagnostic evaluation and treatment].
Kettritz, R.
Deutsche Medizinische Wochenschrift 146 (3): 176-180. February 2021

Volumenmanagement bei chronischen Nierenerkrankungen [Volume management in chronic kidney disease].
Kettritz, R. and Schirmer, S.H. and Heine, G.H.
Deutsche Medizinische Wochenschrift 146 (8): 518-524. April 2021

Recurrent early filter clotting during continuous veno-venous hemodialysis with regional citrate anticoagulation is linked to systemic thrombin generation and heparin induced thrombocytopenia type II: a retrospective analysis.
Khadzhynov, D. and Slowinski, T. and Schreiber, A. and Lieker, I. and Halleck, F. and Lehner, L.J. and Kindgen-Milles, D. and Eckardt, K.U. and Budde, K. and Staeck, O.
Austin Critical Care Case Reports 5 (3): 1032. 30 September 2021

MFSD2A-associated primary microcephaly - expanding the clinical and mutational spectrum of this ultra-rare disease.
Khuller, K. and Yigit, G. and Martínez Grijalva, C. and Altmüller, J. and Thiele, H. and Nürnberg, P. and Elcioglu, N.H. and Yeter, B. and Hehr, U. and Stein, A. and Della Marina, A. and Köninger, A. and Depienne, C. and Kaiser, F.J. and Wollnik, B. and Kuechler, A.
European Journal of Medical Genetics 64 (10): 104310. October 2021

Characterization and modulation of anti- αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Kierkels, G.J.J. and van Diest, E. and Hernández-López, P. and Scheper, W. and de Bruin, A.C.M. and Frijlink, E. and Aarts-Riemens, T. and van Dooremalen, S.F.J. and Beringer, D.X. and Oostvogels, R. and Kramer, L. and Straetemans, T. and Uckert, W. and Sebestyén, Z. and Kuball, J.
Molecular Therapy - Methods and Clinical Development 22 (10): 388-400. 10 September 2021

Donor cell memory confers a metastable state of directly converted cells.
Kim, K.P. and Li, C. and Bunina, D. and Jeong, H.W. and Ghelman, J. and Yoon, J. and Shin, B. and Park, H. and Han, D.W. and Zaugg, J.B. and Kim, J. and Kuhlmann, T. and Adams, R.H. and Noh, K.M. and Goldman, S.A. and Schöler, H.R.
Cell Stem Cell 28 (7): 1291-1306. 1 July 2021

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.
Kircher, T. and Pantsar, T. and Oder, A. and von Kries, J.P. and Juchum, M. and Pfaffenrot, B. and Kloevekorn, P. and Albrecht, W. and Selig, R. and Laufer, S.
European Journal of Medicinal Chemistry 2019 : 112901. 1 January 2021

ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIF–containing protein that controls root growth angle in barley and wheat.
Kirschner, G.K. and Rosignoli, S. and Guo, L. and Vardanega, I. and Imani, J. and Altmüller, J. and Milner, S.G. and Balzano, R: and Nagel, K.A. and Pflugfelder, D. and Forestan, C. and Bovina, R. and Koller, R. and Stöcker, T.G. and Mascher, M. and Simmonds, J. and Uauy, C. and Schoof, H. and Tuberosa, R. and Salvi, S. and Hochholdinger, F.
Proceedings of the National Academy of Sciences of the United States of America 118 (35): e2101526118. 31 August 2021

UNC93B1 is widely expressed in the murine CNS and is required for neuroinflammation and neuronal injury induced by microRNA let-7b.
Klammer, M.G. and Dzaye, O. and Wallach, T. and Krüger, C. and Gaessler, D. and Buonfiglioli, A. and Derkow, K. and Kettenmann, H. and Brinkmann, M.M. and Lehnardt, S.
Frontiers in Immunology 12 : 715774. September 2021

Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells.
Klockmeier, K. and Silva Ramos, E. and Raskó, T. and Martí Pastor, A. and Wanker, E.E.
Journal of Molecular Biology 433 (19): 167184. 17 September 2021

ANK3 related neurodevelopmental disorders: expanding the spectrum of heterozygous loss-of-function variants.
Kloth, K. and Lozic, B. and Tagoe, J. and Hoffer, M.J.V. and Van der Ven, A. and Thiele, H. and Altmüller, J. and Kubisch, C. and Au, P.Y.B. and Denecke, J. and Bijlsma, E.K. and Lessel, D.
Neurogenetics 22 (4): 263-269. October 2021

Retinal thickness analysis in progressive multiple sclerosis patients treated with epigallocatechin gallate: optical coherence tomography results from the SUPREMES study.
Klumbies, K. and Rust, R. and Dörr, J. and Konietschke, F. and Paul, F. and Bellmann-Strobl, J. and Brandt, A.U. and Zimmermann, H.G.
Frontiers in Neurology 12 : 615790. 28 April 2021

Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans.
Klämbt, V. and Werth, M. and Onuchic-Whitford, A.C. and Getwan, M. and Kitzler, T.M. and Buerger, F. and Mao, Y. and Deutsch, K. and Mann, N. and Majmundar, A.J. and Kaminski, M.M. and Shen, Tian and Schmidt-Ott, K.M. and Shalaby, M. and El Desoky, S. and Kari, J.A. and Shril, S. and Lienkamp, S.S. and Barasch, J. and Hildebrandt, F.
Nephrology Dialysis Transplantation 36 (2): 237-246. February 2021

Bioaccumulation of therapeutic drugs by human gut bacteria.
Klünemann, M. and Andrejev, S. and Blasche, S. and Mateus, A. and Phapale, P. and Devendran, S. and Vappiani, J. and Simon, B. and Scott, T.A. and Kafkia, E. and Konstantinidis, D. and Zirngibl, K. and Mastrorilli, E. and Banzhaf, M. and Mackmull, M.T. and Hövelmann, F. and Nesme, L. and Brochado, A.R. and Maier, L. and Bock, T. and Periwal, V. and Kumar, M. and Kim, Y. and Tramontano, M. and Schultz, C. and Beck, M. and Hennig, J. and Zimmermann, M. and Sévin, D.C. and Cabreiro, F. and Savitski, M.M. and Bork, P. and Typas, A. and Patil, K.R.
Nature 597 : 533-538. 23 September 2021

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis.
Kobelt, D. and Perez-Hernandez, D. and Fleuter, C. and Dahlmann, M. and Zincke, F. and Smith, J. and Migotti, R. and Popp, O. and Burock, S. and Walther, W. and Dittmar, G. and Mertins, P. and Stein, U.
Oncogene 40 (34): 5286-5301. 26 August 2021

Real-time cell migration monitoring to analyze drug synergism in the scratch assay using the IncuCyte system.
Kobelt, D. and Walther, W. and Stein, U.S.
Methods in Molecular Biology 2294 : 133-142. 2021

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.
Koester, J. and Miroshnikova, Y.A. and Ghatak, S. and Chacón-Martínez, C.A. and Morgner, J. and Li, X. and Atanassov, I. and Altmüller, J. and Birk, D.E. and Koch, M. and Bloch, W. and Bartusel, M. and Niessen, C.M. and Rada-Iglesias, A. and Wickström, S.A.
Nature Cell Biology 23 (7): 771-781. July 2021

An identical-by-descent novel splice-donor variant in PRUNE1 causes a neurodevelopmental syndrome with prominent dystonia in two consanguineous Sudanese families.
Koko, M. and Yahia, A. and Elsayed, L.E. and Hamed, A.A. and Mohammed, I.N. and Elseed, M.A. and Hamad, M.H.A. and Babai, A.M. and Siddig, R.A. and Abd Allah, A.S.I. and Mohamed, M. and El-Amin, M. and Esteves, T. and Altmüller, J. and Toliat, M.R. and Thiele, H. and Nürnberg, P. and Salih, M.A. and Ahmed, A.E. and Lerche, H. and Stevanin, G.
Annals of Human Genetics 85 (5): 186-195. September 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

Effects of daytime dry fasting on hydration, glucose metabolism and circadian phase: a prospective exploratory cohort study in Bahá'í volunteers.
Koppold-Liebscher, D.A. and Klatte, C. and Demmrich, S. and Schwarz, J. and Kandil, F.I. and Steckhan, N. and Ring, R. and Kessler, C.S. and Jeitler, M. and Koller, B. and Ananthasubramaniam, B. and Eisenmann, C. and Mähler, A. and Boschmann, M. and Kramer, A. and Michalsen, A.
Frontiers in Nutrition 8 : 662310. July 2021

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure.
Kovarik, J. and Morisawa, N. and Wild, J. and Marton, A. and Takase-Minegishi, K. and Minegishi, S. and Daub, S. and Sands, J.M. and Klein, J.D. and Bailey, J.L. and Kovalik, J.P. and Rauh, M. and Karbach, S. and Hilgers, K.F. and Luft, F. and Nishiyama, A. and Nakano, D. and Kitada, K. and Titze, J.
Acta Physiologica 232 (1): e13629. May 2021

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
Kowalczyk, I. and Lee, C. and Schuster, E. and Hoeren, J. and Trivigno, V. and Riedel, L. and Görne, J. and Wallingford, J.B. and Hammes, A. and Feistel, K.
Development 148 (2): dev195008. 26 January 2021

Predictors of major atrial fibrillation endpoints in the National Heart, Lung, and Blood Institute HCMR.
Kramer, C.M. and DiMarco, J.P. and Kolm, P. and Ho, C.Y. and Desai, M.Y. and Kwong, R.Y. and Dolman, S.F. and Geller, N. and Kim, D.Y. and Maron, M.S. and Appelbaum, E. and Jerosch-Herold, M. and Friedrich, M.G. and Schulz-Menger, J. and Piechnik, S.K. and Mahmod, M. and Jacoby, D. and White, J. and Chiribiri, A. and Helms, A. and Choudhury, L. and Michels, M. and Bradlow, W. and Salerno, M. and Dawson, D.K. and Weinsaft, J.W. and Berry, C. and Nagueh, S.F. and Buccarelli-Ducci, C. and Anjali, O. and Casadei, B. and Watkins, H. and Weintraub, W.S. and Neubauer, S.
JACC: Clinical Electrophysiology 7 (11): 1376-1386. November 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Harnett, D. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Günnigmann, M. and Zinnall, U. and Vieira-Vieira, C.H. and Schaub, T. and Münster-Wandowski, A. and Bürger, J. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Ohler, U. and Beule, D. and Mielke, T. and Tarabykin, V. and Landthaler, M. and Kramer, G. and Vida, I. and Selbach, M. and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

PET-guided eBEACOPP treatment of advanced-stage Hodgkin lymphoma (HD18): follow-up analysis of an international, open-label, randomised, phase 3 trial.
Kreissl, S. and Goergen, H. and Buehnen, I. and Kobe, C. and Moccia, A. and Greil, R. and Eichenauer, D.A. and Zijlstra, J.M. and Markova, J. and Meissner, J. and Feuring-Buske, M. and Soekler, M. and Beck, H.J. and Willenbacher, W. and Ludwig, W.D. and Pabst, T. and Topp, M.S. and Hitz, F. and Bentz, M. and Keller, U.B. and Kühnhardt, D. and Ostermann, H. and Hertenstein, B. and Aulitzky, W. and Maschmeyer, G. and Vieler, T. and Eich, H. and Baues, C. and Stein, H. and Fuchs, M. and Diehl, V. and Dietlein, M. and Engert, A. and Borchmann, P.
Lancet Haematology 8 (6): e398-e409. June 2021

Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures.
Kreye, J. and Wright, S.K. and van Casteren, A. and Stoeffler, L. and Machule, M.L. and Reincke, S.M. and Nikolaus, M. and van Hoof, S. and Sanchez-Sendin, E. and Homeyer, M.A. and Gómez, C.C. and Kornau, H.C. and Schmitz, D. and Kaindl, A.M. and Boehm-Sturm, P. and Mueller, S. and Wilson, M.A. and Upadhya, M.A. and Dhangar, D.R. and Greenhill, S. and Woodhall, G. and Turko, P. and Vida, I. and Garner, C.C. and Wickel, J. and Geis, C. and Fukata, Y. and Fukata, M. and Prüss, H.
Journal of Experimental Medicine 218 (11): e20210012. 1 November 2021

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
Kruse, T. and Benz, C. and Garvanska, D.H. and Lindqvist, R. and Mihalic, F. and Coscia, F. and Inturi, R. and Sayadi, A. and Simonetti, L. and Nilsson, E. and Ali, M. and Kliche, J. and Moliner Morro, A. and Mund, A. and Andersson, E. and McInerney, G. and Mann, M. and Jemth, P. and Davey, N.E. and Överby, A.K. and Nilsson, J. and Ivarsson, Y.
Nature Communications 12 (1): 6761. 19 November 2021

MEG reveals preference specific increases of sexual-image-evoked responses in paedophilic sexual offenders and healthy controls.
Krylova, M. and Ristow, I. and Marr, V. and Borchardt, V. and Li, M. and Witzel, J. and Drumkova, K. and Harris, J.A. and Zacharias, N. and Schiltz, K. and Amelung, T. and Beier, K.M. and Kruger, T.H.C. and Ponseti, J. and Schiffer, B. and Walter, H. and Kärgel, C. and Walter, M.
World Journal of Biological Psychiatry 22 (4): 257-270. April 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B. and Knoll, R. and Bonaguro, L. and ToVinh, M. and Raabe, J. and Astaburuaga-García, R. and Schulte-Schrepping, J. and Kaiser, K.M. and Rieke, G.J. and Bischoff, J. and Monin, M.B. and Hoffmeister, C. and Schlabe, S. and De Domenico, E. and Reusch, N. and Händler, K. and Reynolds, G. and Blüthgen, N. and Hack, G. and Finnemann, C. and Nischalke, H.D. and Strassburg, C.P. and Stephenson, E. and Su, Y. and Gardner, L. and Yuan, D. and Chen, D. and Goldman, J. and Rosenstiel, P. and Schmidt, S.V. and Latz, E. and Hrusovsky, K. and Ball, A.J. and Johnson, J.M. and Koenig, P.A. and Schmidt, F.I. and Haniffa, M. and Heath, J.R. and Kümmerer, B.M. and Keitel, V. and Jensen, B. and Stubbemann, P. and Kurth, F. and Sander, L.E. and Sawitzki, B. and Aschenbrenner, A.C. and Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Noninvasive renal perfusion measurement using arterial spin labeling (ASL) MRI: basic concept.
Ku, M.C. and Fernández-Seara, M.A. and Kober, F. and Niendorf, T.
Methods in Molecular Biology 2216 : 229-239. 2021

Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy.
Ku, M.C. and Kober, F. and Lai, Y.C. and Pohlmann, A. and Qadri, F. and Bader, M. and Carrier, L. and Niendorf, T.
Journal of Cardiovascular Magnetic Resonance 23 (1): 63. 31 May 2021

Fluorine ((19)F) MRI for assessing inflammatory cells in the kidney: experimental protocol.
Ku, M.C. and Schreiber, A. and Delgado, P.R. and Boehm-Sturm, P. and Kettritz, R. and Niendorf, T. and Pohlmann, A. and Waiczies, S.
Methods in Molecular Biology 2216 : 495-507. 2021

Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation.
Kubo, N. and Ishii, H. and Xiong, X. and Bianco, S. and Meitinger, F. and Hu, R. and Hocker, J.D. and Conte, M. and Gorkin, D. and Yu, M. and Li, B. and Dixon, J.R. and Hu, M. and Nicodemi, M. and Zhao, H. and Ren, B.
Nature Structural & Molecular Biology 28 (2): 152-161. February 2021

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum.
Kuijpers, M. and Kochlamazashvili, G. and Stumpf, A. and Puchkov, D. and Swaminathan, A. and Lucht, M.T. and Krause, E. and Maritzen, T. and Schmitz, D. and Haucke, V.
Neuron 109 (2): 299-313. 20 January 2021

Dynamic changes in microbiome composition following Mare's milk intake for prevention of collateral antibiotic effect.
Kushugulova, A. and Löber, U. and Akpanova, S. and Rysbekov, K. and Kozhakhmetov, S. and Khassenbekova, Z. and Essex, M. and Nurgozhina, A. and Nurgaziyev, M. and Babenko, D. and Markó, L. and Forslund, S.K.
Frontiers in Cellular and Infection Microbiology 11 : 622735. 21 April 2021

Markers of myocardial damage predict mortality in patients with aortic stenosis.
Kwak, S. and Everett, R.J. and Treibel, T.A. and Yang, S. and Hwang, D. and Ko, T. and Williams, M.C. and Bing, R. and Singh, T. and Joshi, S. and Lee, H. and Lee, W. and Kim, Y.J. and Chin, C.W.L. and Fukui, M. and Al Musa, T. and Rigolli, M. and Singh, A. and Tastet, L. and Dobson, L.E. and Wiesemann, S. and Ferreira, V.M. and Captur, G. and Lee, S. and Schulz-Menger, J. and Schelbert, E.B. and Clavel, M.A. and Park, S.J. and Rheude, T. and Hadamitzky, M. and Gerber, B.L. and Newby, D.E. and Myerson, S.G. and Pibarot, P. and Cavalcante, J.L. and McCann, G.P. and Greenwood, J.P. and Moon, J.C. and Dweck, M.R. and Lee, S.P.
Journal of the American College of Cardiology 78 (6): 545-558. 10 August 2021

Sekundäre Immundefekte bei hämatoonkologischen Erkrankungen.
Käbisch, E. and Na, I.K.
Tagliche Praxis 65 (1): 12-23. 2021

Sekundäre Immundefekte bei hämatoonkologischen Erkrankungen [Secondary immunodeficiency in hematological and oncological diseases].
Käbisch, E. and Na, I.K.
Internistische Praxis 63 (4): 570-581. 2021

Health workforce response to Covid-19: What pandemic preparedness planning and action at the federal and state levels in Germany? Germany's health workforce responses to Covid-19.
Köppen, J. and Hartl, K. and Maier, C.B.
International Journal of Health Planning and Management 36 (S1): 71-91. May 2021

MicroRNA-7a2 regulates prolactin in developing lactotrophs and prolactinoma cells.
LaPierre, M.P. and Godbersen, S. and Esteban, M.T. and Schad, A.N. and Treier, M. and Ghoshdastider, U. and Stoffel, M.
Endocrinology 162 (2): bqaa220. February 2021

Survey of long-term experiences of sperm cryopreservation in oncological and non-oncological patients: usage and reproductive outcomes of a large monocentric cohort.
Lackamp, N. and Wilkemeyer, I. and Jelas, I. and Keller, U. and Bullinger, L. and Stintzing, S. and le Coutre, P.
Frontiers in Oncology 11 : 772809. 5 November 2021

Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration.
Lahmann, I. and Griger, J. and Chen, J.S. and Zhang, Y. and Schülke, M. and Birchmeier-Kohler, C.
eLife 10 : e57356. 5 August 2021

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.
Lareau, C.A. and Ludwig, L.S. and Muus, C. and Gohil, S.H. and Zhao, T. and Chiang, Z. and Pelka, K. and Verboon, J.M. and Luo, W. and Christian, E. and Rosebrock, D. and Getz, G. and Boland, G.M. and Chen, F. and Buenrostro, J.D. and Hacohen, N. and Wu, C.J. and Aryee, M.J. and Regev, A. and Sankaran, V.G.
Nature Biotechnology 39 (4): 451-461. April 2021

Clinical presentation and management of a dinutuximab beta extravasation in a patient with neuroblastoma.
Launspach, M. and Seif, M. and Thole, TM. and Jesse, P. and Schulz, J. and Schulte, J.H. and Bischoff, S. and Eggert, A. and Deubzer, H.E.
Children 8 (2): 91. 29 January 2021

Generation of human brain organoids for mitochondrial disease modeling.
Le, S. and Petersilie, L. and Inak, G. and Menacho-Pando, C. and Kafitz, K.W. and Rybak-Wolf, A. and Rajewsky, N. and Rose, C.R. and Prigione, A.
Journal of Visualized Experiments (172): e62756. 21 June 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Development of a 1,2,4-triazole-based lead tankyrase inhibitor: part II.
Leenders, R.G.G. and Brinch, S.A. and Sowa, S.T. and Amundsen-Isaksen, E. and Galera-Prat, A. and Murthy, S. and Aertssen, S. and Smits, J.N. and Nieczypor, P. and Damen, E. and Wegert, A. and Nazaré, M. and Lehtiö, L. and Waaler, J. and Krauss, S.
Journal of Medicinal Chemistry 64 (24): 17936-17949. 23 December 2021

Targeted disruption of galectin 3 in mice delays the first wave of spermatogenesis and increases germ cell apoptosis.
Lei, T. and Blois, S.M. and Freitag, N. and Bergmann, M. and Bhushan, S. and Wahle, E. and Huang, A.C.C. and Chen, H.L. and Hartmann, M.F. and Wudy, S.A. and Liu, F.T. and Meinhardt, A. and Fijak, M.
Cellular and Molecular Life Sciences 78 (7): 3621-3635. April 2021

Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing.
Leiz, J. and Hinze, C. and Boltengagen, A. and Braeuning, C. and Kocks, C. and Rajewsky, N. and Schmidt-Ott, K.M.
Journal of Visualized Experiments (175): e62901. September 2021

Technologies for profiling the impact of genomic variants on transcription factor binding.
Leiz, J. and Rutkiewicz, M. and Birchmeier, C. and Heinemann, U. and Schmidt-Ott, K.M.
Medizinische Genetik 33 (2): 147-155. 14 August 2021

Circulating HLA-G and its association with cardiovascular markers in pregnancy.
Lekva, T. and Jacobsen, D.P. and Sugulle, M. and Moe, K. and Fjeldstad, H.E.S. and Dechend, R. and Staff, A.C.
Journal of Reproductive Immunology 146 : 103331. August 2021

The Collaborative Research Center FONDA.
Leser, U. and Hilbrich, M. and Draxl, C. and Eisert, P. and Grunske, L. and Hostert, P. and Kainmüller, D. and Kao, O. and Kehr, B. and Kehrer, T. and Koch, C. and Markl, V. and Meyerhenke, H. and Rabl, T. and Reinefeld, A. and Reinert, K. and Ritter, K. and Scheuermann, B. and Schintke, F. and Schweikardt, N. and Weidlich, M.
Datenbank-Spektrum 21 : 255-260. November 2021

SMART: recent updates, new developments and status in 2020.
Letunic, I. and Khedkar, S. and Bork, P.
Nucleic Acids Research 49 (D1): D458-D460. 8 January 2021

The somatosensory world of the African naked mole-rat.
Lewin, G.R. and Smith, E.S.J. and Reznick, J. and Debus, K.Y. and Barker, A.J. and Park, T.J.
Advances in Experimental Medicine and Biology 1319 (1319): 197-220. 24 August 2021

Investigation of spleen CXCR4 expression by [(68)Ga]Pentixafor PET in a cohort of 145 solid cancer patients.
Lewis, R. and Habringer, S. and Kircher, M. and Hefter, M. and Peuker, C.A. and Werner, R. and Ademaj-Kospiri, V. and Gäble, A. and Weber, W. and Wester, H.J. and Buck, A. and Herhaus, P. and Lapa, C. and Keller, U.
EJNMMI Research 11 (1): 77. 21 August 2021

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.
Lewis, R. and Maurer, H.C. and Singh, N. and Gonzalez-Menendez, I. and Wirth, M. and Schick, M. and Zhang, L. and Isaakidis, K. and Scherger, A.K. and Schulze, V. and Lu, J. and Zenz, T. and Steiger, K. and Rad, R. and Quintanilla-Martinez, L. and Espeli, M. and Balabanian, K. and Keller, U. and Habringer, S.
Leukemia 35 : 2895-2905. October 2021