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| Item Type: | Article |
|---|---|
| Title: | Assessing attacks and treatment response rates among adult patients with NMOSD and MOGAD: data from a nationwide registry in Argentina |
| Creators: |
Contentti, E.C.  ORCID: https://orcid.org/0000-0001-7435-5726, Lopez, P.A., Pettinicchi, J.P., Criniti, J., Pappolla, A., Miguez, J., Patrucco, L., Carnero Contentti, E., Liwacki, S., Tkachuk, V., Balbuena, M.E., Vrech, C., Deri, N., Correale, J., Marrodan, M. ORCID: https://orcid.org/0000-0002-4142-8375, Ysrraelit, M.C., Leguizamon, F., Luetic, G. ORCID: https://orcid.org/0000-0002-5716-6082, Menichini, M.L., Tavolini, D., Mainella, C., Zanga, G., Burgos, M., Hryb, J., Barboza, A., Lazaro, L., Alonso, R. ORCID: https://orcid.org/0000-0001-9955-8343, Liguori, N.F., Nadur, D., Chercoff, A. ORCID: https://orcid.org/0000-0002-8645-6134, Alonso Serena, M., Caride, A., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Rojas, J.I.
|
| Abstract: | We aimed to examine treatment interventions implemented in patients experiencing neuromyelitis optica spectrum disorders (NMOSD) attacks (frequency, types, and response). METHODS: Retrospective study. Data on patient demographic, clinical and radiological findings, and administered treatments were collected. Remission status (complete [CR], partial [PR], no remission [NR]), based on changes in the EDSS score was evaluated before treatment, during attack, and at 6 months. CR was analyzed with a generalized estimating equations (GEEs) model. RESULTS: A total of 131 patients (120 NMOSD and 11 myelin oligodendrocyte glycoprotein-antibody-associated diseases [MOGAD]), experiencing 262 NMOSD-related attacks and receiving 270 treatments were included. High-dose steroids (81.4%) was the most frequent treatment followed by plasmapheresis (15.5%). CR from attacks was observed in 47% (105/223) of all treated patients. During the first attack, we observed CR:71.2%, PR:16.3% and NR:12.5% after the first course of treatment. For second, third, fourth, and fifth attacks, CR was observed in 31.1%, 10.7%, 27.3%, and 33.3%, respectively. Remission rates were higher for optic neuritis vs. myelitis (p < 0.001). Predictor of CR in multivariate GEE analysis was age in both NMOSD (OR = 2.27, p = 0.002) and MOGAD (OR = 1.53, p = 0.03). CONCLUSIONS: This study suggests individualization of treatment according to age and attack manifestation. The outcome of attacks was generally poor. |
| Keywords: | Neuromyelitis Optica Spectrum Disorders, Attacks, Disability, Treatment Response, Latin America |
| Source: | Multiple Sclerosis Journal Experimental Translational and Clinical |
| ISSN: | 2055-2173 |
| Publisher: | Sage Publications |
| Volume: | 7 |
| Number: | 3 |
| Page Range: | 20552173211032334 |
| Date: | 1 July 2021 |
| Official Publication: | https://doi.org/10.1177/20552173211032334 |
| PubMed: | View item in PubMed |
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