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| Item Type: | Article |
|---|---|
| Title: | Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination |
| Creators: |
Loyal, L.  ORCID: https://orcid.org/0000-0001-5738-4437, Braun, J. ORCID: https://orcid.org/0000-0002-7788-8154, Henze, L. ORCID: https://orcid.org/0000-0002-6540-4263, Kruse, B., Dingeldey, M. ORCID: https://orcid.org/0000-0001-8412-3910, Reimer, U. ORCID: https://orcid.org/0000-0002-3375-6889, Kern, F. ORCID: https://orcid.org/0000-0002-0368-8408, Schwarz, T. ORCID: https://orcid.org/0000-0002-6054-4750, Mangold, M. ORCID: https://orcid.org/0000-0002-4547-7246, Unger, C. ORCID: https://orcid.org/0000-0003-3760-4791, Dörfler, F., Kadler, S. ORCID: https://orcid.org/0000-0001-9281-4770, Rosowski, J., Gürcan, K., Uyar-Aydin, Z. ORCID: https://orcid.org/0000-0002-6042-8311, Frentsch, M., Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Schnatbaum, K. ORCID: https://orcid.org/0000-0002-2840-6294, Eckey, M. ORCID: https://orcid.org/0000-0002-1431-1569, Hippenstiel, S. ORCID: https://orcid.org/0000-0002-5146-1064, Hocke, A. ORCID: https://orcid.org/0000-0002-6935-8612, Müller, M.A. ORCID: https://orcid.org/0000-0003-2242-5117, Sawitzki, B. ORCID: https://orcid.org/0000-0001-8166-8579, Miltenyi, S., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Mall, M.A. ORCID: https://orcid.org/0000-0002-4057-2199, Wenschuh, H., Voigt, S. ORCID: https://orcid.org/0000-0003-1544-9903, Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, Lauster, R., Lachman, N. ORCID: https://orcid.org/0000-0002-2081-3098, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Corman, V.M. ORCID: https://orcid.org/0000-0002-3605-0136, Röhmel, J. ORCID: https://orcid.org/0000-0002-1535-8852, Meyer-Arndt, L. ORCID: https://orcid.org/0000-0002-7909-020X, Thiel, A. ORCID: https://orcid.org/0000-0002-5515-4002 and Giesecke-Thiel, C. ORCID: https://orcid.org/0000-0002-5927-7018
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| Abstract: | The functional relevance of pre-existing cross-immunity to SARS-CoV-2 is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4(+) T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that pre-existing spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 mRNA vaccination displaying kinetics similar to secondary immune responses. Our results highlight the functional contribution of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity following primary SARS-CoV-2 immunization and the high rate of asymptomatic/mild COVID-19 disease courses. |
| Keywords: | Age Factors, Asymptomatic Diseases, CD3 Complex, CD4-Positive T-Lymphocytes, COVID-19, COVID-19 Vaccines, Coronavirus Spike Glycoprotein, Cross Reactions, Immunity, Immunodominant Epitopes, Open Reading Frames, Peptide Fragments, SARS-CoV-2, Vaccination |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 374 |
| Number: | 6564 |
| Page Range: | eabh1823 |
| Date: | 8 October 2021 |
| Additional Information: | This license (CCBY) does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material. |
| Official Publication: | https://doi.org/10.1126/science.abh1823 |
| PubMed: | View item in PubMed |
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