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| Item Type: | Review |
|---|---|
| Title: | Autophagy in major human diseases |
| Creators: |
Klionsky, D.J.  ORCID: https://orcid.org/0000-0002-7828-8118, Petroni, G., Amaravadi, R.K., Baehrecke, E.H., Ballabio, A. ORCID: https://orcid.org/0000-0003-1381-4604, Boya, P. ORCID: https://orcid.org/0000-0003-3045-951X, Bravo-San Pedro, J.M., Cadwell, K., Cecconi, F. ORCID: https://orcid.org/0000-0002-5614-4359, Choi, A.M.K., Choi, M.E., Chu, C.T. ORCID: https://orcid.org/0000-0002-5052-8271, Codogno, P. ORCID: https://orcid.org/0000-0002-5492-3180, Colombo, M.I., Cuervo, A.M. ORCID: https://orcid.org/0000-0002-0771-700X, Deretic, V., Dikic, I. ORCID: https://orcid.org/0000-0001-8156-9511, Elazar, Z., Eskelinen, E.L., Fimia, G.M. ORCID: https://orcid.org/0000-0003-4438-3325, Gewirtz, D.A. ORCID: https://orcid.org/0000-0003-0437-4934, Green, D.R., Hansen, M., Jäättelä, M. ORCID: https://orcid.org/0000-0001-5950-7111, Johansen, T. ORCID: https://orcid.org/0000-0003-1451-9578, Juhász, G., Karantza, V., Kraft, C. ORCID: https://orcid.org/0000-0002-3324-4701, Kroemer, G. ORCID: https://orcid.org/0000-0002-9334-4405, Ktistakis, N.T., Kumar, S. ORCID: https://orcid.org/0000-0001-7126-9814, Lopez-Otin, C. ORCID: https://orcid.org/0000-0001-6964-1904, Macleod, K.F., Madeo, F., Martinez, J., Meléndez, A., Mizushima, N. ORCID: https://orcid.org/0000-0002-6258-6444, Münz, C. ORCID: https://orcid.org/0000-0001-6419-1940, Penninger, J.M., Perera, R.M. ORCID: https://orcid.org/0000-0003-2435-2273, Piacentini, M. ORCID: https://orcid.org/0000-0003-2919-1296, Reggiori, F. ORCID: https://orcid.org/0000-0003-2652-2686, Rubinsztein, D.C., Ryan, K.M., Sadoshima, J., Santambrogio, L., Scorrano, L. ORCID: https://orcid.org/0000-0002-8515-8928, Simon, H.U., Simon, A.K. ORCID: https://orcid.org/0000-0002-4077-7995, Simonsen, A. ORCID: https://orcid.org/0000-0003-4711-7057, Stolz, A. ORCID: https://orcid.org/0000-0002-3340-439X, Tavernarakis, N. ORCID: https://orcid.org/0000-0002-5253-1466, Tooze, S.A. ORCID: https://orcid.org/0000-0002-2182-3116, Yoshimori, T. ORCID: https://orcid.org/0000-0001-9787-3788, Yuan, J., Yue, Z., Zhong, Q. ORCID: https://orcid.org/0000-0001-6979-955X, Galluzzi, L. ORCID: https://orcid.org/0000-0003-2257-8500 and Pietrocola, F. ORCID: https://orcid.org/0000-0002-2930-234X
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| Abstract: | Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. |
| Keywords: | Aging, Cancer, Inflammation, Metabolic Syndromes, Neurodegeneration, Animals |
| Source: | EMBO Journal |
| ISSN: | 0261-4189 |
| Publisher: | EMBO Press / Wiley |
| Volume: | 40 |
| Number: | 19 |
| Page Range: | e108863 |
| Date: | 1 October 2021 |
| Official Publication: | https://doi.org/10.15252/embj.2021108863 |
| PubMed: | View item in PubMed |
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